活体成像固定装置
By designing a live imaging fixation device consisting of a box body, a lid, and a pressure plate, and using friction and magnetic components to fix the plate, the problem of imaging window jitter in live imaging experiments was solved, and clear and stable image acquisition was achieved.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- GUANGZHOU NAT LAB
- Filing Date
- 2025-07-25
- Publication Date
- 2026-07-17
AI Technical Summary
In in vivo imaging experiments, the imaging window cannot be obtained because respiratory tremors still exist after in vivo anesthesia, making it impossible to obtain stable and clear images.
Design a live imaging fixation device, including a box body, a box cover and a pressure plate. The imaging window is exposed through the observation port on the box cover, and the fixing plate is used with friction and magnetic components to ensure that the imaging window remains stable during the observation process.
This method achieves stable fixation of the imaging window in live imaging experiments, ensuring the acquisition of clear and stable images and reducing the impact of breathing vibrations.
Smart Images
Figure CN224505654U_ABST
Abstract
Claims
1. An in vivo imaging fixture, comprising: include: The box body (10) is provided with a cavity (11) for accommodating the living body to be observed. The lid (20) is connected to the body (10) and is used to partially cover the cavity (11). The lid (20) has a first observation port (21) communicating with the cavity (11). The first observation port (21) is used to expose the imaging window (72) pre-implanted in the living body in the cavity (11). A pressure plate (30) is connected to the side of the box cover (20) away from the box body (10). The pressure plate (30) has a second observation port (31) that is aligned with the first observation port (21). The pressure plate (30) is used to clamp and fix the card plate (71) connected to the imaging window (72) between the pressure plate (30) and the box cover (20).
2. The live imaging fixation device of claim 1, wherein, The box cover (20) has a receiving groove (22) formed on the outer periphery of the first observation port (21), and the receiving groove (22) is used to receive the card plate (71); The pressure plate (30) is provided with a boss (32), which is inserted into the receiving groove (22) and used to abut against the card plate (71). The second observation port (31) passes through the boss (32).
3. The live imaging fixation device of claim 1, wherein, The box cover (20) is provided with a first friction member on the side near the pressure plate (30), and the first friction member is used to abut against one side of the card plate (71); The pressure plate (30) is provided with a second friction member on the side near the box cover (20), and the second friction member is used to abut against the other side of the card plate (71).
4. The live imaging fixation device of claim 3, wherein, The lid (20) and the pressure plate (30) are stacked together, and the first friction member and the second friction member are misaligned in the stacking direction of the lid (20) and the pressure plate (30).
5. The live imaging fixation device of claim 3, wherein, The number of the first friction elements is multiple, and the multiple first friction elements are arranged at intervals along the outer periphery of the first observation port (21); and / or, The number of the second friction elements is multiple, and the multiple second friction elements are arranged at intervals along the outer periphery of the second observation port (31).
6. The live imaging fixation device of claim 3, wherein, The lid (20) has a first groove (23), the first friction member is disposed in the first groove (23), and at least a portion of the first friction member protrudes from the opening of the first groove (23); and / or, The pressure plate (30) has a second groove (33), the second friction member is disposed in the second groove (33), and at least a portion of the second friction member protrudes from the opening of the second groove (33).
7. The live imaging fixation device of claim 1, wherein, The cover (20) has a first screw hole (24), and the pressure plate (30) has a first through hole (34) aligned with the first screw hole (24). The live imaging fixation device also includes a first connector (35), which passes through the first through hole (34) and is threaded into the first screw hole (24); and / or, The box cover (20) is provided with a first magnetic element, and the pressure plate (30) is provided with a second magnetic element that is aligned with the first magnetic element. The first magnetic element and the second magnetic element are magnetically attracted to each other.
8. The live imaging fixation device of claim 1, wherein, The housing (10) has a second screw hole, and the housing cover (20) has a second through hole aligned with the second screw hole. The live imaging fixation device also includes a second connector, which passes through the second through hole and is threaded into the second screw hole; and / or, The box body (10) is provided with a third magnetic component (14), and the box cover (20) is provided with a fourth magnetic component (25) that is aligned with the third magnetic component (14). The third magnetic component (14) and the fourth magnetic component (25) are magnetically attracted to each other.
9. The live imaging fixation device of claim 1, wherein, The box body (10) is provided with a fifth magnetic element (15) on the side opposite to the box cover (20), and the box body (10) can be magnetically attracted to the stage (60) of the microscope by the fifth magnetic element (15).
10. The live imaging fixation device of claim 1, wherein, The box (10) has a connecting port (111) on one side that communicates with the cavity (11), and the connecting port (111) is used to insert the gas anesthesia tube of the ventilator.
11. The live imaging fixation device of claim 10, wherein, A clamp assembly (12) is fixed at the inlet (111) of the tube, and the clamp assembly (12) is used to fix the tube to the gas anesthesia tube.
12. The live imaging fixation device of claim 11, wherein, The clamp assembly (12) includes a first clamp (121) and a second clamp (122). The first clamp (121) is fixedly connected to the box body (10), and the second clamp (122) is detachably connected to the first clamp (121) through a threaded connector (123). The first clamp (121) and the second clamp (122) are used to clamp together on the gas anesthesia tube to fix the gas anesthesia tube.
13. The live imaging fixture of claim 1, wherein, A heating pad is provided in the cavity (11) for keeping the living body warm.
14. The live imaging fixation device of claim 13, wherein, The box body (10) has an insulated opening (112) for the heating pad to enter and exit the cavity (11).
15. The live imaging fixation device of claim 14, wherein, The live imaging fixation device also includes a heat preservation curtain (50), which is connected to the box body (10) and covers the heat preservation opening (112).