A small specific protein analyzer

Abstract

The utility model discloses a small specific protein analysis appearance, including instrument frame, the reagent detection module, sample adding arm group module, stirring arm group module, pH value and specific gravity detection module are arranged in the instrument frame, the reagent detection module includes the fixed installation of fixed installation's bath disc from outside to inside coaxial arrangement on the base, the sample detection turntable of rotary installation, the fixed installation's reagent refrigerator and the reagent turntable of rotary installation, a plurality of reagent sites have on the reagent turntable, a plurality of sample sites and a plurality of reaction cup sites have on the sample detection turntable, the bath disc has optical detection module group, the sample adding arm group module includes sample adding needle, the sample adding needle has two movement degrees of freedom of Y direction and Z direction, the stirring arm group module includes stirring needle, and the stirring needle has two movement degrees of freedom of Y direction and Z direction.

Description

Technical Field

[0001] This utility model belongs to the field of protein analysis technology and relates to a small-specific protein analyzer. Background Technology

[0002] Specific proteins, also known as specialty proteins, are proteins derived from tissue cells and widely distributed in serum that perform specific functions, carrying out various important biological functions. Many diseases can cause changes in serum proteins, making specific proteins important clinical diagnostic indicators. Existing specific protein analyzers are mostly large-scale devices with high costs. Existing smaller devices lack automation and do not involve pH and specific gravity detection. Therefore, designing a small specific protein analyzer to address these issues is particularly necessary. Utility Model Content

[0003] To address the shortcomings of existing technologies, this invention provides a small-specific protein analyzer.

[0004] To achieve the above objectives, the technical solution of this utility model is: a small-specific protein analyzer, comprising an instrument frame, characterized in that the instrument frame is equipped with a reagent detection module, a sample loading arm module, a stirring arm module, and a pH and specific gravity detection module. The reagent detection module includes a fixedly mounted warm bath disk, a rotatably mounted sample detection turntable, a fixedly mounted reagent refrigerator, and a rotatably mounted reagent turntable, arranged coaxially from the outside to the inside on a base. The reagent turntable has several reagent positions, and the sample detection turntable has several sample positions and several reaction cup positions. The warm bath disk has an optical detection module. The sample loading arm module includes a sample loading needle with two degrees of freedom of movement in the Y and Z directions. The stirring arm module includes a stirring needle with two degrees of freedom of movement in the Y and Z directions.

[0005] The instrument frame is also connected to an X-axis adjustable worktable, which has a detection placement port.

[0006] The pH and specific gravity detection module includes a detection cell with a pH detection electrode fixed at the top. An inlet pipe and an outlet pipe are installed on both sides of the detection cell. The inlet pipe is connected to the detection placement port through a pipeline. A peristaltic pump is installed on the pipeline. A refractometer prism is fixed below the detection cell. An LED light board and a linear PD detection board are installed on both sides below the detection cell. A polarizing lens is also arranged between the linear PD detection board and the detection cell.

[0007] The base is fixed with a top cover, which has an opening for taking out and putting in, a stirring opening and an operating opening. The top cover also has a handle that can close the operating opening.

[0008] The stirring needle is driven by a DC motor to rotate at high speed.

[0009] By adopting the above technical solution, the beneficial effects of this utility model are: This invention ensures high automation while featuring a compact structure and small size. It is also compatible with pH and specific gravity detection, making it suitable for a wider range of applications. Furthermore, it offers a cost advantage and can meet diverse needs. Attached Figure Description

[0010] Figure 1 This is a schematic diagram of the three-dimensional structure of this utility model. Figure 1 ; Figure 2 This is a schematic diagram of the three-dimensional structure of this utility model. Figure 2 ; Figure 3 This is a schematic diagram of the three-dimensional structure of this utility model. Figure 3 ; Figure 4 This is a three-dimensional structural diagram of the intermediate-drug detection module of this utility model. Figure 1 ; Figure 5 This is a three-dimensional structural diagram of the intermediate-drug detection module of this utility model. Figure 2 ; Figure 6 This is a cross-sectional view of the pH and specific gravity detection module in this utility model; Figure 7 This is a magnified view of a portion of point A; In the diagram, 1. Reagent detection module; 101. Base; 107. Drive motor one; 108. Reagent turntable; 109. Reagent refrigerator; 111. Warm bath disc; 112. Reagent bottle; 113. Reagent pull-out basket; 141. Sample tube; 115. Sample pull-out basket; 116. Sample detection turntable; 117. Reaction cup; 118. Optical detection module; 125. Drive motor two; 129. Handle cover; 130. Top cover; 130a. Loading / unloading port; 130b. Stirring port; 2. Sample dispensing arm assembly module; 201 1. Sampling needle; 202. Sampling needle washing tank; 203. Plunger pump; 3. Stirring arm assembly module; 301. Stirring needle; 302. Stirring needle washing tank; 303. DC motor; 4. pH and specific gravity detection module; 401. Detection cell; 402. Inlet pipe; 403. Refractometer prism; 404. LED light panel; 407. Linear PD detection board; 408. Polarizing lens; 409. Outlet pipe; 410. Sealing ring; 411. pH detection electrode; 414. Peristaltic pump; 415. Detection placement port. Detailed Implementation

[0011] To further explain the technical solution of this utility model, the following detailed description is provided through specific embodiments.

[0012] like Figure 1-7 As shown, this small-scale specific protein analyzer includes an instrument frame, with a housing fixed outside the frame. Inside the instrument frame are arranged a reagent detection module 1, a sample loading arm module 2, a stirring arm module 3, and a pH and specific gravity detection module 4. The reagent detection module 1 includes a base 101 on which a fixedly mounted warm bath disc 111, a rotatably mounted sample detection turntable 116, a fixedly mounted reagent refrigerator 109, and a rotatably mounted reagent turntable 108 are coaxially arranged from the outside to the inside. In this embodiment, the warm bath disc 111 has a heating wire at its bottom for heating function, providing the reactants with the temperature required for the reaction. The refrigerator 109 can be water-cooled, air-cooled, or a combination of both, which is existing technology. The reagent turntable 108 is driven by a drive motor 107, and the sample detection turntable 116 is driven by a drive motor 125. The reagent turntable 108 has several reagent positions. In practice, reagent bottles 112 are placed into reagent baskets 113, and then the reagent baskets 113 are placed onto the reagent turntable 108, which is existing technology. The sample detection turntable 116 has several sample positions and several reaction cup positions. In practice, the sample... The tube 141 is inserted into the sample basket 115, and then the sample basket 115 is inserted into the sample detection turntable 116. The reaction cup 117 is installed on the sample detection turntable 116. The reaction cup 117 is a ten-piece reaction cup. The warm bath disc 111 has an optical detection module 118. The optical detection module 118 adopts an existing structure and has eight optical detection channels. While the reaction cup 117 is rotating, the optical signal in the reaction cup 117 can be read, thereby calculating the required detection information. The signal reading, transmission and calculation adopt existing technology. The sample dispensing arm module 2 is packaged. The system includes a sampling needle 201, which has two degrees of freedom of movement in the Y and Z directions. The movement of the sampling needle 201 in the Y and Z directions is achieved using existing technology. It also includes a plunger pump 203 that works in conjunction with the sampling needle 201 to provide the sampling function. This also uses an existing structure. The stirring arm assembly module 3 includes a stirring needle 301, which has two degrees of freedom of movement in the Y and Z directions. Specifically, the stirring needle 301 is driven to rotate at high speed by a DC motor 303. The movement of the stirring needle 301 in the Y and Z directions is achieved using existing technology.

[0013] The instrument frame is also connected to an X-axis adjustable worktable with a detection placement port 415. After the sample is drawn by the sampling needle 201, it is moved to the detection placement port 415 and then fed into the detection pool 401 by the peristaltic pump 414.

[0014] The pH and specific gravity detection module 4 includes a detection pool 401, with a pH detection electrode 411 fixed on the upper part of the detection pool 401. The detection pool 401 and the pH detection electrode 411 are sealed together by a sealing ring 410. An inlet pipe 402 and an outlet pipe 409 are respectively installed on both sides of the detection pool 401. The inlet pipe 402 is connected to the detection placement port 415 through a pipeline, and a peristaltic pump 414 is installed on the pipeline. A refractometer prism 403 is fixed below the detection pool 401. An LED light board 404 and a linear PD detection board 407 are respectively installed on both sides below the detection pool 401. A polarizing lens 408 is also arranged between the linear PD detection board 407 and the detection pool 401. In this embodiment, the pH detection electrode 411 detects the pH of the sample in the detection pool 401 using existing technology, and the refractometer prism 403, LED light board 404, linear PD detection board 407 and polarizing lens 408 work together to detect the specific gravity, which also uses existing technology.

[0015] A top cover 130 is fixed on the base 101. The top cover 130 has an opening for taking out and putting in, an opening for stirring, and an opening for operation. The top cover 130 also has a handle cover 129 that can close the opening for operation.

[0016] Reagent Detection Module 1: The reagent refrigerator 109 can accommodate up to twenty-four reagent positions. The reagent turntable 108 is driven by a drive motor 107 and can rotate at any angle to reach a designated position. This rotation is achieved using existing technology. Outside the reagent refrigerator 109 is an independently rotatable sample detection turntable 116, which has twenty-four sample positions and eight ten-unit reaction cup positions. The sample detection turntable 116 is driven by a drive motor 125 and can rotate at a designated angle. This rotation is achieved using existing technology. The reaction cup 117 rotates within a warm bath disc 111, which provides heating to provide the required temperature for the reaction of the reactants in the reaction cup 117. The warm bath disc 111 has eight optical detection channels, which can read the optical signals in the reaction cup 117 while it is rotating, thereby calculating the required detection information.

[0017] Sample loading arm module 2: Equipped with a sample loading needle 201 with two degrees of freedom of movement (Y and Z), it ensures accurate sample transfer and quantitative distribution through existing mechanical transmission and sensor control, avoids human error, and improves the repeatability and accuracy of detection.

[0018] Stirring arm module 3: Equipped with stirring needles 301 that have two degrees of freedom of movement (Y and Z), it ensures thorough mixing and reaction of reagent samples through existing mechanical transmission and sensor control.

[0019] pH and specific gravity detection module 4: Combines pH detection electrode 411 and specific gravity optical test, and delivers sample to detection cell 401 through peristaltic pump 414, while measuring the pH and specific gravity of the sample.

[0020] In practice, it also includes a needle washing pool 202 fixed on the workbench and a needle washing pool 302 fixed on the frame to clean the needles 201 and 301. At the same time, the tubing is cleaned after each experiment. This uses existing technology to ensure that there is no cross-contamination.

[0021] In summary, this invention mainly utilizes a dual-rotor design with refrigeration function, which greatly saves the space required for samples, reagents, and reactions. At the same time, it can complete the detection of pH value and specific gravity in one go.

[0022] All of the above components are general standard parts or components known to those skilled in the art. Their structure and principles can be learned by those skilled in the art through technical manuals or conventional experimental methods.

[0023] The above embodiments and figures are not intended to limit the product form and style of this utility model. Any appropriate changes or modifications made by those skilled in the art should be considered as not departing from the patent scope of this utility model.

Claims

1. A small-specific protein analyzer, comprising an instrument frame, characterized in that, The instrument frame is equipped with a reagent detection module (1), a sample loading arm module (2), a stirring arm module (3), and a pH and specific gravity detection module (4). The reagent detection module (1) includes a fixedly installed warm bath disk (111), a rotatably installed sample detection turntable (116), a fixedly installed reagent refrigerator (109), and a rotatably installed reagent turntable (108) arranged coaxially from the outside to the inside on a base (101). The reagent turntable (108) has several reagent positions, the sample detection turntable (116) has several sample positions and several reaction cup positions, and the warm bath disk (111) has an optical detection module (118). The sample loading arm module (2) includes a sample loading needle (201), which has two degrees of freedom of movement in the Y and Z directions. The stirring arm module (3) includes a stirring needle (301), which has two degrees of freedom of movement in the Y and Z directions.

2. The small-specific protein analyzer according to claim 1, characterized in that, The instrument frame is also connected to an X-axis position-adjustable worktable, which has a detection placement port (415).

3. The small-specific protein analyzer according to claim 1, characterized in that, The pH and specific gravity detection module (4) includes a detection pool (401), a pH detection electrode (411) is fixed on the upper part of the detection pool (401), an inlet pipe (402) and an outlet pipe (409) are respectively installed on both sides of the detection pool (401), the inlet pipe (402) is connected to the detection placement port (415) through a pipeline, a peristaltic pump (414) is provided on the pipeline, a refractometer prism (403) is fixed below the detection pool (401), an LED light board (404) and a linear PD detection board (407) are respectively installed on both sides below the detection pool (401), and a polarizing lens (408) is arranged between the linear PD detection board (407) and the detection pool (401).

4. The small-specific protein analyzer according to claim 1, characterized in that, The base (101) is fixed with a top cover (130), which has an opening for taking out and putting in (130a), a stirring opening (130b) and an operating opening. The top cover (130) has a handle cover (129) that can close the operating opening.

5. A small-specific protein analyzer according to claim 1, characterized in that, The stirring needle (301) is driven to rotate at high speed by a DC motor (303).

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