A moisture control drying apparatus

Abstract

The utility model relates to raw material medicine production technical field, in order to solve how to effectively remove the crystallization water in raw material medicine in the drying process while retaining the crystallization water in raw material medicine, and not adopt negative pressure drying, and avoid the technical problem that the crystallization water content increases due to humidity is too high, the utility model discloses a kind of humidity control drying device, including humidification tank, mixing tank and hot air circulation oven, humidification tank has the first gas inlet of input nitrogen and the first gas outlet for output nitrogen, float flowmeter is equipped in the first gas inlet, and the first gas outlet is connected with mixing tank by pipeline;Mixing tank has the second gas inlet of input nitrogen and the third gas inlet connected with the first gas outlet, and adjusting valve controlled by PLC controller is equipped in the second gas inlet, and mixing tank is provided with second gas outlet;Hot air circulation oven has the air inlet connected with second gas outlet, and the moisture exhaust port for excluding water vapor.Precise control humidity, retain crystallization water, remove acetone.

Description

Technical Field

[0001] This utility model relates to the field of active pharmaceutical ingredient (API) production technology, and in particular to a humidity-controlled drying device. Background Technology

[0002] In the production process of a certain active pharmaceutical ingredient (API) A, the drying process is a crucial step. API A is a compound with seven molecules of water of crystallization, and the specific requirements for its drying process stem from its interaction with acetone and the stability of its water of crystallization. Acetone is a commonly used solvent with a relatively low boiling point, approximately 30 degrees Celsius. Since API A dissolves in acetone, the volatilization of acetone and the retention of its water of crystallization become particularly important during the subsequent drying process.

[0003] The drying process of active pharmaceutical ingredient (API) A presents significant challenges, primarily because its water of crystallization is easily lost when below or near the boiling point of acetone. While acetone evaporates at around 30 degrees Celsius under normal pressure, the boiling points of both acetone and its water of crystallization decrease further under negative pressure, increasing the operational difficulty of the drying process. Especially under negative pressure drying, the water of crystallization in API A evaporates more readily, leading to substandard product quality. Therefore, negative pressure drying is not suitable for this scenario.

[0004] Humidity control during the drying process is also a crucial factor. Excessive humidity during drying will cause active pharmaceutical ingredient (API) A to absorb more water, increasing its water of crystallization content, which will also lead to unqualified drying. Since changes in the water of crystallization content directly affect the final product quality of API A, humidity during the drying process needs to be strictly controlled to ensure the product meets the required standards.

[0005] Solving the above problems is directly related to the product quality and production efficiency of active pharmaceutical ingredient A. Utility Model Content

[0006] The purpose of this invention is to provide a humidity-controlled drying device to solve the technical problem of how to effectively remove acetone while retaining the water of crystallization in the raw material during the drying process, without using negative pressure drying, and avoiding the increase in water of crystallization content due to excessive humidity.

[0007] To achieve the above objectives, this utility model provides a humidity-controlled drying device, including a humidifying tank, a mixing tank, and a hot air circulating oven. The humidifying tank has a first inlet for inputting nitrogen and a first outlet for outputting nitrogen. A float flow meter is installed at the first inlet, and the first outlet is connected to the mixing tank via a pipeline. The mixing tank has a second inlet for inputting nitrogen and a third inlet connected to the first outlet. A regulating valve controlled by a PLC controller is installed at the second inlet, and the mixing tank has a second outlet. The hot air circulating oven has an air inlet connected to the second outlet and a dehumidification outlet for removing moisture.

[0008] The device achieves precise control of nitrogen humidity through a float flow meter inside the humidification tank and a regulating valve (24) controlled by a PLC controller. The humidification tank can adjust the humidity of nitrogen as needed to ensure that the nitrogen entering the mixing tank reaches the ideal humidity level. This helps to accurately control humidity conditions during the drying process, avoiding over- or under-drying, thereby ensuring product quality.

[0009] By controlling the humidity with nitrogen and adjusting the temperature of the hot air circulating oven, the water of crystallization in the product can be effectively retained while removing solvents (such as acetone). This prevents the loss of water of crystallization and ensures that the solvent completely evaporates during the drying process, achieving the desired drying effect.

[0010] The combined design of the humidification tank and mixing tank allows for the control and regulation of humidity levels in the drying environment, preventing excessive moisture absorption by the product due to high humidity, which could lead to increased water of crystallization. By precisely regulating humidity during the drying process, the product's drying performance is improved by avoiding issues caused by excessive humidity, thus increasing production efficiency and product yield.

[0011] This device uses a hot air circulating oven and nitrogen circulation to remove solvents, instead of negative pressure drying. This effectively avoids the problem of excessively rapid evaporation of water of crystallization in the product under negative pressure. By combining circulating nitrogen and hot air, drying can be completed under normal pressure conditions, reducing equipment complexity and operational risks, and is also suitable for drying products that are sensitive to pressure changes.

[0012] This invention utilizes a nitrogen circulation system to effectively reduce solvent evaporation and waste, thereby lowering energy consumption. The hot air circulating oven operates under normal pressure, avoiding the high energy consumption of negative pressure equipment and reducing environmental impact, making it a more energy-efficient and environmentally friendly drying solution.

[0013] In one embodiment, the humidifier tank contains a humidifier, and a pipe connected to the first air inlet leads into the humidifier.

[0014] This method can more effectively increase the humidity of nitrogen entering the drying system. By passing nitrogen through a humidifier, it absorbs moisture, resulting in higher humidity levels in the nitrogen entering the mixing tank and hot air circulating oven. Controlling the nitrogen humidity level helps maintain the water of crystallization in active pharmaceutical ingredient A, preventing excessive loss of water of crystallization during drying and improving product quality stability. Furthermore, using a humidifier provides more controllable and stable humidity conditions, meeting the requirements of the drying process.

[0015] In one embodiment, the side wall of the hot air circulating oven is provided with an inlet for hot water to enter and an outlet for hot water to exit.

[0016] By inlet and outlet water outlets, hot water can circulate inside the hot air circulating oven, a design that allows for precise control of humidity within the oven. By adjusting the inlet and outlet hot water flow rates, the equipment can stably maintain a set humidity range. This is crucial for removing acetone without losing water of crystallization during the drying process, as appropriate humidity allows acetone to volatilize effectively without causing water of crystallization to evaporate or leading to overheating of the material. Furthermore, precise humidity control helps improve the efficiency and uniformity of the drying process, further ensuring product quality and consistency.

[0017] In one embodiment, the side wall of the hot air circulating oven is also provided with a humidity sensor for feeding back the humidity inside the hot air circulating oven to the PLC controller.

[0018] The humidity sensor allows for real-time monitoring of the humidity inside the oven and provides feedback to the PLC controller. This real-time humidity monitoring facilitates automated humidity control, ensuring that the hot air circulating oven remains within the optimal humidity range. It prevents uneven drying, insufficient acetone evaporation, or excessive loss of water of crystallization caused by humidity fluctuations.

[0019] The humidity-controlled drying device provided by this utility model has the following advantages:

[0020] By combining a humidification tank and a mixing tank, and utilizing a float flow meter and a PLC controller-controlled regulating valve within the humidification tank, the humidity of nitrogen is precisely controlled. This ensures that the nitrogen entering the hot air circulating oven reaches a suitable humidity level, effectively removing acetone while retaining the water of crystallization in the raw material during drying at atmospheric pressure, preventing excessive loss or increase of water of crystallization. The hot air circulating oven design, with its inlet and outlet, achieves internal hot water circulation, precisely controlling the oven's humidity and preventing the evaporation of water of crystallization due to excessive humidity. Humidity sensors feed back information to the PLC controller, dynamically adjusting the humidity to ensure the uniformity and effectiveness of the drying process. This solves the humidity control problem in the drying process at atmospheric pressure, thereby improving production efficiency and product quality consistency. Attached Figure Description

[0021] Figure 1 This is a schematic diagram of the humidity control and drying device provided by this utility model.

[0022] In the diagram: 10, humidifier tank; 20, mixing tank; 30, hot air circulating oven; 40, PLC controller;

[0023] 11. First air inlet; 12. First air outlet; 13. Float flow meter; 21. Second air inlet; 22. Third air inlet; 23. Second air outlet; 24. Regulating valve; 31. Air inlet; 32. Dehumidification outlet; 33. Water inlet; 34. Water outlet; 35. Humidity sensor. Detailed Implementation

[0024] To make the objectives, technical solutions, and advantages of this utility model clearer, the present utility model will be further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain this utility model and are not intended to limit this utility model.

[0025] See Figure 1 This utility model provides a humidity-controlled drying device, including a humidifying tank 10, a mixing tank 20 and a hot air circulating oven 30, which form a combination.

[0026] The humidifier tank 10 has a top cover with a first air inlet 11 for inputting nitrogen and a first air outlet 12 for outputting nitrogen. A float flow meter 13 is installed at the first air inlet 11. The humidifier tank 10 is used to increase the humidity of the nitrogen. The humidifier tank 10 is filled with water. The pipe connected to the first air inlet 11 passes through the water. The first air outlet 12 is connected to the mixing tank 20 through a pipe.

[0027] The mixing tank 20 has a top cover with a second air inlet 21 for inputting nitrogen and a third air inlet 22 connected to the first air outlet 12. The second air inlet 21 is equipped with a regulating valve controlled by a PLC controller 40 and has a second air outlet 23 connected to the hot air circulating oven 30.

[0028] The hot air circulating oven 30 has an air inlet 21 connected to the second air outlet 23 via a pipeline on its top, and a dehumidification outlet 32 ​​for removing moisture after drying; the side wall of the hot air circulating oven 30 has a water inlet 33 for entering hot water and a water outlet 34 for discharging hot water; the side wall of the hot air circulating oven 30 also has a humidity sensor 35 for feeding back the internal humidity of the hot air circulating oven 30 to the PLC controller 40.

[0029] The humidity-controlled drying device provided by this utility model has the following advantages:

[0030] Precise control of nitrogen humidity is achieved through a float flow meter and a regulating valve controlled by a PLC controller within the humidification tank. The humidifier in the humidification tank effectively increases the humidity of the nitrogen, ensuring that the nitrogen entering the mixing tank and hot air circulating oven reaches the ideal humidity level. This helps maintain the water of crystallization in raw material A during the drying process, preventing excessive loss and thus improving product quality stability. Furthermore, the hot air circulating oven is equipped with inlet and outlet water outlets, allowing hot water circulation within the oven. Adjusting the water flow rate precisely controls the oven humidity, ensuring effective evaporation of acetone during drying while preventing the evaporation of water of crystallization or overheating of the material. This ensures uniformity and efficiency in drying, improving product quality consistency. A humidity sensor within the hot air circulating oven monitors the internal humidity in real time and feeds it back to the PLC controller, automatically adjusting the heating system to ensure precise humidity control. This adapts to the humidity requirements during the drying process, preventing uneven drying or loss of water of crystallization due to humidity fluctuations, thereby reducing operational risks and improving production efficiency and product qualification rate. The overall design operates under normal pressure, and avoids the problem of excessively rapid evaporation of crystal water under negative pressure by combining nitrogen and hot air circulation, and reduces energy consumption by reducing solvent evaporation.

[0031] In summary, the humidity-controlled drying device provided by this utility model achieves precise control of the drying process through the comprehensive application of nitrogen humidity control and hot air circulation, effectively improving the drying quality and production efficiency of products, and meeting the drying needs of products with strict requirements on humidity and moisture content.

[0032] The above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A moisture control drying apparatus comprising a humidifying tank (10), a mixing tank (20) and a hot air circulating oven (30), characterized in that, The humidification tank (10) has a first air inlet (11) for inputting nitrogen and a first air outlet (12) for outputting nitrogen. A float flow meter (13) is provided at the first air inlet (11), and the first air outlet (12) is connected to the mixing tank (20) through a pipeline. The mixing tank (20) has a second inlet (21) for inputting nitrogen and a third inlet (22) connected to the first outlet (12). The second inlet (21) is provided with a regulating valve (24) controlled by a PLC controller (40). The mixing tank (20) is provided with a second outlet (23). The hot air circulating oven (30) has an air inlet (31) connected to a second air outlet (23) and a dehumidification outlet (32) for removing moisture.

2. The moisture control drying apparatus of claim 1, wherein, The humidifier tank (10) contains a humidifier, and the pipe connected to the first air inlet (11) leads into the humidifier.

3. The moisture control drying apparatus of claim 2, wherein, The side wall of the hot air circulating oven (30) is provided with an inlet (33) for hot water to enter and an outlet (34) for hot water to exit.

4. The moisture control drying apparatus of claim 3, wherein, The side wall of the hot air circulating oven (30) is also provided with a humidity sensor (35) for feeding back the humidity inside the hot air circulating oven (30) to the PLC controller (40).

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