A multi-particle-size-adjustable pharmaceutical excipient granulator

Abstract

The utility model discloses a kind of multi-particle size adjustable medicinal excipient granulator, including granulating cylinder, fixedly connected with fixed granulating net in the side edge opening of granulating cylinder, the inside of the lateral wall of granulating cylinder is equipped with receiving groove, two layers of movable granulating net are slidably connected with the inside receiving of receiving groove, the surface of granulating cylinder is provided with limit sliding slot below movable granulating net, the above of granulating cylinder is equipped with feeding cylinder;The utility model is by being provided with fixed granulating net and two layers of movable granulating net in the side edge of granulating cylinder, the size of aperture is continuously regulated using the overlapping cooperation of movable granulating net and fixed granulating net, and multiple-particle size requirement can be flexibly adapted.The design breaks through the limitation of traditional single screen mesh corresponding single particle size, reaches adjustable particle size by pure mechanical structure, does not need to replace granulating net during shutdown, significantly improves regulation efficiency and production continuity.

Description

Technical Field

[0001] This utility model relates to the field of granulation machine technology, specifically to a pharmaceutical excipient granulation machine with adjustable particle size. Background Technology

[0002] In pharmaceutical formulation production, the particle morphology of pharmaceutical excipients, especially their size and distribution, directly affects key properties such as solubility, stability, and bioavailability of drugs. As a crucial piece of equipment for controlling particle size, the particle size adjustment capability and flexibility of pharmaceutical excipient granulators are of paramount importance in pharmaceutical production.

[0003] Existing pharmaceutical excipient granulation machines mostly use single, fixed screen structures. If the particle size needs to be changed, the machine must be stopped to disassemble and replace the screen with one of the corresponding aperture size. This operation is cumbersome and time-consuming, severely impacting production continuity. Furthermore, a single set of screens can only accommodate a specific particle size range, making it difficult to meet the diverse needs of different dosage forms for pharmaceutical excipient particles. This results in poor equipment versatility, increased production costs, and greater equipment management difficulty. Therefore, a new technical solution is proposed to address this issue. Utility Model Content

[0004] The purpose of this invention is to provide a pharmaceutical excipient granulator with adjustable particle size, which solves the problem mentioned in the background art that the existing pharmaceutical excipient granulators have a single fixed structure of screens. If the particle size needs to be changed, the machine must be stopped, the screens disassembled and replaced with screens of the corresponding aperture size. This operation is cumbersome and time-consuming, which seriously affects the continuity of production.

[0005] To achieve the above objectives, this utility model provides the following technical solution: a pharmaceutical excipient granulator with adjustable particle size, comprising a granulation cylinder, a fixed granulation mesh fixedly connected to the side opening of the granulation cylinder, a receiving groove provided inside the side wall of the granulation cylinder, two layers of movable granulation mesh being received and slidably connected to the inner side of the receiving groove, a limiting groove being provided on the surface of the granulation cylinder directly below the movable granulation mesh, and a feeding cylinder provided above the granulation cylinder.

[0006] In this technical solution, a fixed granulating screen and two layers of movable granulating screens are set on the side of the granulation cylinder. The overlapping and cooperation of the movable and fixed granulating screens achieves continuous adjustment of the pore size, which can flexibly adapt to multiple particle size requirements. This design breaks through the limitation of traditional single screen corresponding to single particle size. It achieves adjustable particle size with a purely mechanical structure, without the need to stop the machine to replace the granulating screen, significantly improving adjustment efficiency and production continuity.

[0007] Preferably, positioning plates are fixedly connected to the lower ends of the left and right side walls of the feed cylinder. The positioning plates are attached to the side wall surfaces of the lower granulation cylinder from the left and right sides, and fixing bolts are threaded through and connected to the surface of the positioning plates.

[0008] Preferably, a servo motor is fixedly connected to the center of the bottom of the granulation cylinder, and the tail end of the drive shaft of the servo motor is connected to the bottom end of the rotating rod through a coupling. The rotating rod is located in the center of the granulation cylinder.

[0009] Preferably, a plurality of fan blades are fixedly connected to the top end of the rotating rod, and a feed inlet is provided on the side wall of the feed cylinder below the fan blades. A plurality of cutting blades are fixedly connected to the surface of the rotating rod inside the granulation cylinder.

[0010] Preferably, a collection frame is provided below the granulation cylinder, and the collection frame is detachably connected to the granulation cylinder by mounting bolts.

[0011] Preferably, a screw is threaded through and connected to the side wall edge of the movable granulation screen, and a screw hole is provided on the outer side wall of the granulation cylinder corresponding to the horizontal height of the screw.

[0012] Compared with the prior art, the beneficial effects of this utility model are as follows:

[0013] 1. This utility model, by setting a fixed granulating screen and two layers of movable granulating screens on the side of the granulating cylinder, utilizes the overlapping and cooperation of the movable and fixed granulating screens to achieve continuous adjustment of pore size, flexibly adapting to multiple particle size requirements. This design breaks through the limitation of traditional single screens corresponding to single particle sizes, achieving adjustable particle size through a purely mechanical structure, without the need to stop the machine to replace the granulating screen, significantly improving adjustment efficiency and production continuity.

[0014] 2. This utility model features a detachable feed cylinder above the granulation cylinder, which, when disassembled, directly exposes the internal storage groove of the granulation cylinder. This facilitates quick loading and unloading of the movable granulation screen and allows for easy replacement of different models of movable granulation screens to achieve diverse particle size combinations after overlapping. This significantly enhances the adaptability of the device to different production scenarios and improves the practical value of the equipment. Attached Figure Description

[0015] Other features, objects, and advantages of this invention will become more apparent from the following detailed description of non-limiting embodiments with reference to the accompanying drawings:

[0016] Figure 1 This is an overall view of the present invention;

[0017] Figure 2 This is a cross-sectional schematic diagram of the present invention;

[0018] Figure 3 This is a diagram showing the positional relationship between the feed cylinder and the granulation cylinder of this utility model;

[0019] Figure 4 This is a schematic diagram of the internal structure of the granulation cylinder of this utility model.

[0020] In the diagram: 1. Collection frame; 101. Mounting bolt; 2. Granulation cylinder; 201. Storage trough; 202. Limiting slide; 3. Movable granulation screen; 301. Screw; 302. Screw hole; 4. Servo motor; 5. Rotating rod; 501. Cutting blade; 502. Fan blade; 6. Feed cylinder; 601. Feed inlet; 602. Positioning plate; 603. Fixing bolt; 7. Fixing granulation screen. Detailed Implementation

[0021] To make the technical means, creative features, objectives and effects of this utility model easier to understand, the following description will further elaborate on them in conjunction with specific embodiments.

[0022] A multi-particle-size adjustable pharmaceutical excipient granulator, see [link / reference]. Figures 1 to 4 The system includes a granulation cylinder 2, with a fixed granulation screen 7 fixedly connected to its side opening. A receiving groove 201 is located inside the side wall of the granulation cylinder 2, housing and slidably connecting two layers of movable granulation screens 3. A limiting groove 202 is formed on the surface of the granulation cylinder 2 directly below the movable granulation screens 3. The receiving groove 201 provides a stable sliding track for the movable granulation screens 3, and the limiting groove 202 restricts the movement range of the movable granulation screens 3, preventing misalignment during adjustment. By pushing the movable granulation screens 3 to slide within the receiving groove 201, both layers of movable granulation screens 3 can be used simultaneously or only one layer can be used to overlap with the fixed granulation screen 7, thereby obtaining different aperture sizes and achieving particle size control. This design breaks through the limitations of traditional single-screen-corresponding-to-single-particle-size technology, achieving adjustable particle size through a purely mechanical structure without the need for machine downtime to replace the granulation screens, significantly improving adjustment efficiency and production continuity.

[0023] It is worth noting that, such as Figure 4 As shown, a screw 301 is threaded through and connected to the side wall edge of the movable granulating mesh 3. The outer wall of the granulating cylinder 2 corresponding to the horizontal height of the screw 301 has a screw hole 302. When the movable granulating mesh 3 is adjusted to the target position, the screw 301 is screwed into the corresponding screw hole 302. The relative position of the movable granulating mesh 3 and the granulating cylinder 2 can be fixed by mechanical locking to prevent the movable granulating mesh 3 from shifting due to vibration during granulation and to ensure stable pore size. It should be noted that the screw 301 penetrates both layers of the movable granulating mesh 3 at the same time. Therefore, when fixing, both layers can be fixed at the same time through the screw hole 302, or the inner layer can be fixed separately to ensure stability.

[0024] Specifically, such as Figure 1 and Figure 3As shown, a feed cylinder 6 is provided above the granulation cylinder 2. Positioning plates 602 are fixedly connected to the lower ends of the left and right side walls of the feed cylinder 6. The positioning plates 602 are attached to the side wall surfaces of the lower granulation cylinder 2 from the left and right sides, and fixing bolts 603 are threaded through and connected to the surface of the positioning plates 602. The positioning plates 602 achieve the initial positioning of the feed cylinder 6 by attaching to the side wall of the granulation cylinder 2. After the fixing bolts 603 are tightened, the feed cylinder 6 can be connected to the granulation cylinder 2 to ensure the structural stability during feeding. When disassembling, the bolts can be loosened to separate the two, exposing the storage groove 201 for operation of the movable granulation screen 3. This connection method not only ensures the stability of the feed cylinder 6 installation, but also realizes quick disassembly and assembly, solving the problem that the adjustment parts are difficult to access in the traditional integrated structure, and improving the convenience of equipment maintenance.

[0025] Furthermore, such as Figure 1 and Figure 2 As shown, a servo motor 4 is fixedly connected to the center of the bottom of the granulation cylinder 2. The tail end of the drive shaft of the servo motor 4 is connected to the bottom end of the rotating rod 5 via a coupling. The rotating rod 5 is located in the center of the granulation cylinder 2. Several fan blades 502 are fixedly connected to the top of the rotating rod 5. The side wall of the feed cylinder 6 below the fan blades 502 is provided with a feed inlet 601. Several cutting blades 501 are fixedly connected to the surface of the rotating rod 5 inside the granulation cylinder 2. In use, the servo motor 4 drives the rotating rod 5 to rotate, and the top fan blades 502 rotate with it, which can evenly distribute the material entering from the feed inlet 601. The material is evenly dispersed and pushed downwards; the lower cutting blade 501 rotates synchronously at high speed to cut and crush the material, making it into particles that conform to the pore size, and finally discharged through the granulation screen. The linkage design of the fan blade 502 and the cutting blade 501 enables coordinated operation. The stable output of the servo motor 4 ensures uniform cutting force, reduces particle size deviation, and improves granulation quality and efficiency. Driven by the exhaust of the fan blade 502, the cut material will move towards the fixed granulation screen 7 under the action of the air until it is the right size to pass through the fixed granulation screen 7.

[0026] It is worth noting that, such as Figure 1 and Figure 2 As shown, a collection frame 1 is provided below the granulation cylinder 2. The collection frame 1 is detachably connected to the granulation cylinder 2 by mounting bolts 101. The particles that are fixed by the granulation mesh 7 fall naturally into the collection frame 1 to complete the collection. The connection method of the mounting bolts 101 allows the collection frame 1 to be quickly disassembled, which is convenient for emptying the particles and cleaning the frame.

[0027] In addition, all components designed in this utility model are general standard parts or components known to those skilled in the art. Their structure and principle can be learned by those skilled in the art through technical manuals or conventional experimental methods. Those skilled in the art can fully implement them, so there is no need to elaborate. The content protected by this utility model does not involve improvements to the internal structure and method.

Claims

1. A multi-particle-size adjustable pharmaceutical excipient granulator, comprising a granulation cylinder (2), characterized in that: A fixed granulation mesh (7) is fixedly connected to the side opening of the granulation cylinder (2). A receiving groove (201) is provided inside the side wall of the granulation cylinder (2). Two layers of movable granulation mesh (3) are received and slidably connected inside the receiving groove (201). A limiting groove (202) is opened on the surface of the granulation cylinder (2) directly below the movable granulation mesh (3). A feeding cylinder (6) is provided above the granulation cylinder (2).

2. The pharmaceutical excipient granulator with adjustable particle size according to claim 1, characterized in that: Positioning plates (602) are fixedly connected to the lower ends of the left and right side walls of the feed cylinder (6). The positioning plates (602) are attached to the side wall surfaces of the lower granulation cylinder (2) from the left and right sides, and fixing bolts (603) are threaded through and connected to the surface of the positioning plates (602).

3. The pharmaceutical excipient granulator with adjustable particle size according to claim 1, characterized in that: A servo motor (4) is fixedly connected to the center of the bottom of the granulation cylinder (2). The tail end of the drive shaft of the servo motor (4) is connected to the bottom end of the rotating rod (5) through a coupling. The rotating rod (5) is located in the center of the granulation cylinder (2).

4. A pharmaceutical excipient granulator with adjustable particle size according to claim 3, characterized in that: The top of the rotating rod (5) is fixedly connected with several fan blades (502), and the side wall of the feed cylinder (6) below the fan blades (502) is provided with a feed inlet (601). Several cutting blades (501) are fixedly connected to the surface of the rotating rod (5) inside the granulation cylinder (2).

5. A pharmaceutical excipient granulator with adjustable particle size according to claim 1, characterized in that: A collection frame (1) is provided below the granulation cylinder (2), and the collection frame (1) is detachably connected to the granulation cylinder (2) by mounting bolts (101).

6. The pharmaceutical excipient granulator with adjustable particle size according to claim 1, characterized in that: A screw (301) is threaded through and connected to the side wall edge of the movable granulation mesh (3), and a screw hole (302) is provided on the outer side wall of the granulation cylinder (2) corresponding to the horizontal height of the screw (301).

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