Anti-interference medicine impurity separation and detection device

Abstract

This utility model discloses an interference-resistant drug impurity separation and detection device, comprising a housing with a connecting pipe installed on its lower interior side, and a liquid chromatograph installed on the left side of the connecting pipe; a mounting groove located in the middle of the housing interior, with a filter structure installed inside the mounting groove, the filter structure including a fixing plate and a filter plate; a water pump located at the upper end of the housing, with an installation pipe installed on the lower side of the water pump, and a flexible hose connected to the upper side of the water pump; a connecting pad connected to the upper interior side of the housing, and a limiting structure connected to the rear interior side of the housing, the limiting structure including a moving plate, a connecting block, and a mounting rod. This interference-resistant drug impurity separation and detection device, with its limiting structure, can fix the mobile phase solution container, thereby avoiding separation failure due to solution ratio deviation, and with its filter structure, can filter the mobile phase solution, thereby preventing the matrix from affecting the detection results.

Description

Technical Field

[0001] This utility model relates to the field of drug impurity separation and detection technology, specifically to an interference-resistant drug impurity separation and detection device. Background Technology

[0002] Drug impurity separation and detection device refers to a device for detecting and separating impurities in drugs. It is a specialized piece of equipment used in the drug production process to separate, identify and detect impurities, and its core function is to ensure the purity and safety of drugs.

[0003] Based on existing solutions and actual production and processing applications, current drug impurity separation and detection devices still have some problems, such as: When a drug impurity separation and detection device detects and separates drug impurities, it directly extracts the mobile phase solution into a liquid chromatograph for detection. However, since the mobile phase solution may contain some matrix (or particulate matter), it can lead to errors in the drug impurity separation and detection results. When a drug impurity separation and detection device is used, placing the mobile phase solution container on the ground during the detection process can cause it to shake when kicked, resulting in a deviation in the solution ratio and leading to separation failure. Therefore, this invention provides an interference-resistant drug impurity separation and detection device to solve the above-mentioned problems. Utility Model Content

[0004] The purpose of this invention is to provide an interference-resistant drug impurity separation and detection device to solve the problems mentioned in the background art. When the drug impurity separation and detection device directly extracts the mobile phase solution into the liquid chromatograph for detection, some matrix (or particulate matter) in the mobile phase solution may be present, which may cause errors in the drug impurity separation and detection results. Furthermore, when the drug impurity separation and detection device is placed on the ground during the detection process, the mobile phase solution container may shake when kicked, resulting in a deviation in the solution ratio and causing separation failure.

[0005] To achieve the above objectives, the present invention provides the following technical solution: an anti-interference drug impurity separation and detection device, comprising a housing, wherein a connecting pipe is installed on the lower side of the housing, and a liquid chromatograph is installed on the left side of the connecting pipe; Also includes: The mounting slot is located inside the middle of the housing, and a filter structure is installed inside the mounting slot. The filter structure includes a fixing plate and a filter plate. The fixing plate is fixedly installed inside the left side of the mounting slot, and the filter plate is connected to the upper side of the fixing plate. A water pump is located at the top of the housing, and an installation pipe is installed on the lower side of the water pump. A flexible hose is connected to the upper side of the water pump, and a container is connected to the lower side of the flexible hose. A connecting pad is connected to the upper inside of the housing, and a limiting structure is connected to the rear inside of the housing. The limiting structure includes a movable plate, a connecting block, and an installation rod. The installation rod is installed on the rear inside of the housing, and the movable plate is connected to the outer side of the installation rod. A connecting block is installed on the front side of the movable plate.

[0006] Preferably, a fixing block is fixedly installed on the outer side of the right end of the box, and a connecting plate is movably installed on the right side of the fixing block, and a connecting fixing rod is movably installed on the outer side of the connecting plate.

[0007] Preferably, the fixing plate and the filter plate are connected in a close fit, and the filter plates are symmetrically distributed about the center line of the mounting groove.

[0008] Preferably, a mounting block is fixedly installed on the middle side of the left end of the connecting plate, and a connecting limit rod is movably installed on the outer side of the middle part of the mounting block.

[0009] Preferably, the connecting plate and the fixing block are connected by a snap-fit ​​connection, and a protrusion structure is provided on the outer left side of the connecting plate.

[0010] Preferably, the mounting block and the connecting limiting rod are connected by a thread, and the inner side of the connecting limiting rod is connected to the outer side of the right end of the filter plate, and a sealing plate is also fixedly installed on the right end of the filter plate.

[0011] Preferably, the movable plate and the connecting block are fixedly connected, and the connecting block and the container are fitted together, and the cross-sectional shape of the movable plate is a "U" shape.

[0012] Preferably, the movable plate and the mounting rod are connected by a thread, and the mounting rod and the housing are connected by a rotatable connection.

[0013] Compared with the prior art, the beneficial effects of this utility model are: the anti-interference drug impurity separation and detection device is equipped with a limiting structure, which can fix the container of the mobile phase solution, thereby avoiding separation failure caused by solution ratio deviation, and is equipped with a filtration structure, which can filter the mobile phase solution, thereby avoiding the matrix from affecting the detection results. By placing the container on the upper side of the box and mounting it on the rear side of the connecting pad, rotating the mounting rod causes it to rotate inside the rear side of the box. This causes the moving plate, which is threadedly connected to the mounting rod, to move the connecting block forward, thereby fixing the container with the connecting block and the connecting pad. This makes it easier to fix the container and avoids separation failure caused by solution ratio deviation. By inserting a hose into the container and starting the water pump, the water pump draws the mobile phase solution from inside the container into the installation tube through the hose. This allows the mobile phase solution to enter the installation tank through the installation tube, where a filter plate is installed to filter the mobile phase solution, preventing the presence of matrix in the mobile phase solution from affecting the test results. By rotating the connecting fixing rod, the connecting fixing rod is threaded onto the outside of the connecting plate, causing the connecting fixing rod to move to the right. This allows the connecting fixing rod to separate from the inside of the fixing block. Pulling the connecting plate to the right causes the connecting plate to move the filter plate to the right inside the mounting groove, causing the filter plate to separate from the upper side of the fixing plate. This allows the filter plate to separate from the inside of the mounting groove. Rotating the connecting limiting rod causes the connecting limiting rod to be threaded onto the outside of the middle part of the mounting block, causing the connecting limiting rod to move outward. This allows the connecting limiting rod to separate from the outside of the right end of the filter plate, facilitating the disassembly and replacement of the filter plate. Attached Figure Description

[0014] Figure 1 This is a schematic cross-sectional view of the connection between the housing and the connecting pipe of this utility model. Figure 2 This utility model Figure 1 Enlarged structural diagram at point A in the middle; Figure 3 This utility model Figure 1 Enlarged structural diagram at point B; Figure 4 This is a schematic cross-sectional view of the connection between the filter plate and the mounting groove of this utility model. Figure 5 This is a schematic cross-sectional view of the connection between the container and the box body of this utility model; Figure 6 This utility model Figure 5 Enlarged structural diagram at point C.

[0015] In the diagram: 1. Chamber; 2. Liquid Chromatograph; 3. Connecting pipe; 4. Mounting groove; 5. Fixing plate; 6. Filter plate; 7. Connecting plate; 8. Connecting fixing rod; 9. Mounting pipe; 10. Water pump; 11. Hose; 12. Container; 13. Fixing block; 14. Sealing plate; 15. Mounting block; 16. Connecting limit rod; 17. Moving plate; 18. Connecting block; 19. Mounting rod; 20. Connecting gasket. Detailed Implementation

[0016] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0017] Please see Figure 1-6 This utility model provides a technical solution: an anti-interference drug impurity separation and detection device, comprising: a housing 1, a liquid chromatograph 2, a connecting pipe 3, a mounting groove 4, a fixing plate 5, a filter plate 6, a connecting plate 7, a connecting fixing rod 8, a mounting pipe 9, a water pump 10, a hose 11, a container 12, a fixing block 13, a sealing plate 14, a mounting block 15, a connecting limiting rod 16, a moving plate 17, a connecting block 18, a mounting rod 19, and a connecting pad 20. In operation, the specific details are as follows... Figure 1 , Figure 4 , Figure 5 and Figure 6 As shown, a connecting pad 20 is fixedly installed on the upper side inside the box 1, an installation rod 19 is movably installed on the rear side inside the box 1, a movable plate 17 is threadedly connected to the outer side of the installation rod 19, a connecting block 18 is fixedly installed on the front side of the movable plate 17, and a container 12 is movably installed on the inner side of the connecting block 18. The container 12 is manually placed on the upper side of the box 1 so that the container 12 fits against the rear side of the connecting pad 20. Then, the installation rod 19 installed on the rear side of the box 1 is manually rotated so that the installation rod 19 rotates inside the box 1. This causes the movable plate 17 to move forward inside the box 1 through the threaded transmission connection. Then, the movable plate 17 drives the connecting block 18 fixedly connected to the movable plate 17 to move forward inside the box 1. This causes the connecting block 18 and the connecting pad 20 to clamp the container 12, which is convenient for installing and limiting the container 12. Then, the hose 11 is manually inserted into the upper end of the container 12 and pushed downward so that the hose 11 is inserted into the inside of the container 12 under the action of thrust. Specific examples Figure 1 and Figure 4As shown, a water pump 10 is fixedly installed on the middle side of the upper end of the housing 1, a hose 11 is installed on the upper side of the water pump 10, an installation pipe 9 is fixedly installed on the lower side of the water pump 10, a controller is fixedly installed on the left side of the housing 1, an installation groove 4 is opened in the middle side of the inside of the housing 1, a fixing plate 5 is fixedly installed on the left side of the inside of the installation groove 4, and a filter plate 6 is movably installed on the upper side of the fixing plate 5. The controller controls the water pump 10 on the middle side of the upper end of the housing 1 to start, so that the mobile phase formic acid aqueous solution and methanol inside the container 12 are drawn into the inside of the installation pipe 9 through the hose 11 driven by the water pump 10. Thus, the mobile phase formic acid aqueous solution and methanol flow into the inside of the installation groove 4 through the installation pipe 9, so that the filter plate 6 installed inside the installation groove 4 can remove the matrix in the mobile phase formic acid aqueous solution and methanol, avoid the matrix from interfering with the drug detection results, and thus prevent interference in drug detection. Specific examples Figure 1 As shown, the formic acid aqueous solution and methanol in the mobile phase inside the liquid chromatograph 2 are drawn through the connecting pipe 3 into the degasser inside the liquid chromatograph 2 by the high-pressure pump inside the mounting tank 4. After degassing, the formic acid aqueous solution and methanol are mixed by the proportioning valve and then enter the injector through the one-way valve. The injector enters the stationary phase, which is a reverse chromatographic column packed with octadecane-bonded silica gel. The filtered sample solution enters the mobile phase through the injector. Since the components in the sample solution have different partition coefficients in the two phases, they undergo repeated adsorption-desorption partitioning processes during relative movement between the two phases. As a result, the components have significant differences in their migration speed and are separated into individual components that flow out of the column sequentially. When passing through the detector, the sample concentration is converted into an electrical signal and transmitted to the recorder. Specific examples Figure 1 , Figure 2 , Figure 3 and Figure 5As shown, a fixing block 13 is fixedly installed on the right end of the housing 1, a connecting plate 7 is movably installed on the right side of the fixing block 13, a connecting fixing rod 8 is movably installed on the outside of the connecting plate 7, an installation block 15 is fixedly installed on the left side of the middle of the connecting fixing rod 8, and a connecting limiting rod 16 is movably installed on the outside of the installation block 15. Manually turning the connecting fixing rod 8 installed on the outside of the connecting plate 7 causes the connecting fixing rod 8 to be threaded onto the outside of the connecting plate 7, thereby causing the connecting fixing rod 8 to move to the right. This movement of the connecting fixing rod 8 to the right causes it to separate from the fixing block 13. Then, manually pulling the connecting plate 7 to the right causes the connecting plate 7 to... The filter plate 6 is slid to the right inside the mounting groove 4, which in turn causes the sealing plate 14 to slide to the right inside the housing 1. This allows the filter plate 6 to separate from the upper side of the fixing plate 5 and from the inside of the mounting groove 4, making it easy to remove the filter plate 6 from the inside of the mounting groove 4. Then, by manually turning the connecting limit rod 16, the connecting limit rod 16 is threaded to the outer side of the middle part of the mounting block 15. This causes the connecting limit rod 16 to move outward, and then the connecting limit rod 16 separates from the outer side of the right end of the filter plate 6, making it easy to disassemble and replace the individual filter plate 6.

[0018] All standard parts used in this utility model can be purchased from the market, and irregular parts can be customized according to the description and drawings. The specific connection methods of each part adopt conventional methods such as bolts, rivets, and welding that are mature in the prior art. The machinery, parts and equipment adopt conventional models in the prior art. In addition, the circuit connection adopts conventional connection methods in the prior art, which will not be described in detail here. The contents not described in detail in this specification belong to the prior art known to those skilled in the art.

[0019] Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. An anti-interference drug impurity separation and detection device, comprising a housing (1), a connecting pipe (3) installed on the lower side of the housing, and a liquid chromatograph (2) installed on the left side of the connecting pipe (3); Its features are, Also includes: The mounting slot (4) is located inside the middle side of the box (1), and a filter structure is installed inside the mounting slot (4). The filter structure includes a fixing plate (5) and a filter plate (6). The fixing plate (5) is fixedly installed inside the left side of the mounting slot (4), and the filter plate (6) is connected to the upper side of the fixing plate (5). A water pump (10) is installed at the upper end of the housing (1), and an installation pipe (9) is installed on the lower side of the water pump (10). A hose (11) is connected to the upper side of the water pump (10), and a container (12) is connected to the lower side of the hose (11). A connecting pad (20) is connected to the upper side of the inside of the housing (1), and a limiting structure is connected to the rear side of the inside of the housing (1). The limiting structure includes a moving plate (17), a connecting block (18), and an installation rod (19). The installation rod (19) is installed on the rear side of the inside of the housing (1). The moving plate (17) is connected to the outer side of the installation rod (19), and the connecting block (18) is installed on the front side of the moving plate (17).

2. The anti-interference drug impurity separation and detection device according to claim 1, characterized in that: A fixing block (13) is fixedly installed on the outer side of the right end of the box (1), and a connecting plate (7) is movably installed on the right side of the fixing block (13), and a connecting fixing rod (8) is movably installed on the outer side of the connecting plate (7).

3. The anti-interference drug impurity separation and detection device according to claim 1, characterized in that: The fixing plate (5) and the filter plate (6) are connected in a close fit, and the filter plate (6) is symmetrically distributed about the center line of the mounting groove (4).

4. The anti-interference drug impurity separation and detection device according to claim 2, characterized in that: An installation block (15) is fixedly installed on the middle side of the left end of the connecting plate (7), and a connecting limit rod (16) is movably installed on the outer side of the middle part of the installation block (15).

5. The anti-interference drug impurity separation and detection device according to claim 4, characterized in that: The connecting plate (7) and the fixing block (13) are connected by a snap-fit ​​connection, and a protrusion structure is provided on the outer side of the left end of the connecting plate (7).

6. The anti-interference drug impurity separation and detection device according to claim 4, characterized in that: The mounting block (15) and the connecting limit rod (16) are connected by threads, and the inner side of the connecting limit rod (16) is connected to the outer side of the right end of the filter plate (6), and a sealing plate (14) is also fixedly installed on the right end of the filter plate (6).

7. The anti-interference drug impurity separation and detection device according to claim 1, characterized in that: The movable plate (17) is fixedly connected to the connecting block (18), and the connecting block (18) is fitted to the container (12). The cross-sectional shape of the movable plate (17) is a "U" shape.

8. The anti-interference drug impurity separation and detection device according to claim 7, characterized in that: The movable plate (17) is threadedly connected to the mounting rod (19), and the mounting rod (19) is rotatably connected to the housing (1).

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