A continuous hydrogenation apparatus for the preparation of a rilugolimab intermediate

Abstract

The utility model relates to a preparation technical field of relugolix, especially a relugolix intermediate device is prepared in continuous hydrogenation, including mixing device, fixedly connected with the connecting pipe of mixing device bottom surface, fixedly connected with the lift pump box of connecting pipe far from mixing device one side, fixedly connected with the reaction device of lift pump box far from mixing device one side, fixedly connected with the gas liquid separation device of reaction device far from lift pump box one side, the mixing device includes the bucket body, fixedly connected with the feeding bin of bucket body front, opens in the feed inlet of feeding bin top surface. The utility model discloses through the linkage structure of motor drive pivot and mixing fan of mixing device, ensures that the reaction reagent is fully and evenly mixed in the bucket body, and the connecting pipe of the protection design of lift pump box cooperates sealed flange, makes mixed solution to be able to stable delivery to the reaction device, and the reaction kettle is equipped with heating wire and temperature and pressure inductor, and cooperates the real -time monitoring and the adjusting function of control panel.

Description

Technical Field

[0001] This utility model relates to the field of retinoic acid preparation technology, specifically to an apparatus for the continuous hydrogenation preparation of retinoic acid intermediates. Background Technology

[0002] Relugoline is the first and only oral gonadotropin-releasing hormone receptor antagonist for the treatment of advanced prostate cancer, and has the potential to be used for indications such as uterine fibroids, endometriosis, and prostate cancer.

[0003] The current process for preparing rilugoli typically involves mixing the stock solution with the reaction reagents, then transferring the mixed solution for reaction. The separation process also requires transferring the reacted solution before placing it into the equipment for separation. These multiple transfer processes reduce processing efficiency. Utility Model Content

[0004] To overcome the problem of reduced processing efficiency caused by the need for multiple transfers in the current preparation process.

[0005] The present invention provides a device for the continuous hydrogenation preparation of rilugoli intermediates, comprising a mixing device, a connecting pipe fixedly connected to the bottom of the mixing device, a booster pump box fixedly connected to the side of the connecting pipe away from the mixing device, a reaction device fixedly connected to the side of the booster pump box away from the mixing device, and a gas-liquid separation device fixedly connected to the side of the reaction device away from the booster pump box. The mixing device includes a barrel body, a feeding box fixedly connected to the front of the barrel body, a feeding port opened on the top surface of the feeding box, a bracket fixedly connected to the side of the barrel body, a motor fixedly connected to the top surface of the barrel body, a rotating shaft fixedly connected to the top surface of the inner side of the barrel body, a mixing fan fixedly connected to the side of the rotating shaft, and a control panel fixedly connected to the front of the feeding box. The booster pump box includes a protective box and a booster pump fixedly connected to the inside of the protective box; The reaction apparatus includes a reaction vessel, a heating wire fixedly connected to the inside of the reaction vessel, a temperature sensor fixedly connected to the inside of the reaction vessel, and a pressure sensor fixedly connected to the inside of the reaction vessel. The gas-liquid separation device includes a working tank, a liquid outlet pipe located at the bottom of the working tank, and a gas outlet pipe located on the side of the working tank.

[0006] Preferably, the barrel and connecting pipe, the booster pump and the interior of the reaction tank and the working tank are connected.

[0007] Preferably, the temperature sensor is model CWDZ11 and the pressure sensor is model CYYZ11.

[0008] Preferably, the motor and the booster pump are electrically connected to the heating wire and the control panel.

[0009] Preferably, the inner side of the control panel is provided with an information processing module, a data collection module, and a timing module.

[0010] Preferably, a sealing flange is provided at the connection between the connecting pipe and the equipment.

[0011] Compared with the prior art, this utility model provides an apparatus for the continuous hydrogenation preparation of rilugoli intermediates, which has the following beneficial effects: 1. This utility model uses a linkage structure between a motor-driven rotating shaft and a mixing fan in the mixing device to ensure that the reaction reagents are fully and evenly mixed in the tank. The protective design of the pump box, combined with the connecting pipe of the sealed flange, enables the mixed solution to be delivered to the reaction device. The reaction tank is equipped with heating wires and temperature and pressure sensors. With the real-time adjustment and temperature and pressure display functions of the control panel, the required temperature and pressure environment for the reaction can be accurately maintained, avoiding reaction failure or safety hazards due to parameter loss. The gas-liquid separation device uses an independent working tank structure to efficiently separate the reaction products into liquid and gas components, which are finally discharged through the liquid outlet pipe and gas outlet pipe respectively, forming a complete closed preparation device. 2. In this invention, the solution in the mixing device is pressurized by a booster pump and then enters the reaction tank. Under precise temperature and pressure control, the hydrogenation reaction is completed. The mixture after the reaction flows into the gas-liquid separation device. Since the gas and liquid have different densities, when the liquid and gas are mixed and flow together, the centrifugal force on the liquid is greater than that on the gas. Therefore, the liquid tends to separate by centrifugal force. The liquid adheres to the separation wall and gathers downwards due to gravity. It is then discharged through the discharge pipe. The design of the sealing flange effectively prevents gas leakage and maintains stable system pressure. At the same time, the protective box structure improves the safety of equipment operation. Attached Figure Description

[0012] Figure 1 This is a cross-sectional structural diagram of the present invention; Figure 2 This is a three-dimensional structural diagram of the present invention; Figure 3 This is a schematic diagram of the reaction device structure of this utility model; Figure 4 This is a cross-sectional structural diagram of the mixing device of this utility model.

[0013] In the diagram: 1. Mixing device; 101. Barrel body; 102. Feeding box; 103. Feed inlet; 104. Support; 105. Motor; 106. Rotating shaft; 107. Mixing fan; 108. Control panel; 2. Booster pump box; 201. Protective box; 202. Booster pump; 3. Reaction device; 301. Reaction vessel; 302. Heating wire; 303. Temperature sensor; 304. Pressure sensor; 4. Gas-liquid separation device; 401. Working vessel; 402. Liquid outlet pipe; 403. Gas outlet pipe; 5. Connecting pipe. Detailed Implementation

[0014] The present invention will be further described below with reference to the accompanying drawings and embodiments.

[0015] An apparatus for the continuous hydrogenation preparation of rilugoli intermediates, according to Figures 1-4 As shown, it includes a mixing device 1, a connecting pipe 5 fixedly connected to the bottom surface of the mixing device 1, a lift pump box 2 fixedly connected to the side of the connecting pipe 5 away from the mixing device 1, a reaction device 3 fixedly connected to the side of the lift pump box 2 away from the mixing device 1, and a gas-liquid separation device 4 fixedly connected to the side of the reaction device 3 away from the lift pump box 2. The mixing device 1 includes a barrel 101, a feeding box 102 fixedly connected to the front of the barrel 101, a feeding port 103 opened on the top surface of the feeding box 102, a bracket 104 fixedly connected to the side of the barrel 101, a motor 105 fixedly connected to the top surface of the barrel 101, a rotating shaft 106 fixedly connected to the inner top surface of the barrel 101, a mixing fan 107 fixedly connected to the side of the rotating shaft 106, and a control panel 108 fixedly connected to the front of the feeding box 102. The booster pump box 2 includes a protective box 201 and a booster pump 202 fixedly connected to the inside of the protective box 201; The reaction device 3 includes a reaction vessel 301, a heating wire 302 fixedly connected to the inside of the reaction vessel 301, a temperature sensor 303 fixedly connected to the inside of the reaction vessel 301, and a pressure sensor 304 fixedly connected to the inside of the reaction vessel 301. The gas-liquid separation device 4 includes a working tank 401, a liquid outlet pipe 402 opened on the bottom surface of the working tank 401, and a gas outlet pipe 403 opened on the side surface of the working tank 401.

[0016] according to Figure 1 As shown, the barrel 101, connecting pipe 5, and booster pump 202 are connected to the interior of reaction tank 301 and working tank 401.

[0017] It should be noted that the booster pump 202 and the connecting pipe can help the solution that has been mixed with the reaction reagent inside the barrel 101 enter the reaction tank 301 and react in the reaction tank 301. After the reaction is completed, it enters the working tank 401 and is discharged after gas-liquid separation.

[0018] according to Figure 1 As shown, the temperature sensor 303 is model CWDZ11, and the pressure sensor 304 is model CYYZ11.

[0019] It should be noted that during the preparation of rilugoli intermediates, temperature and pressure need to be properly controlled to avoid preparation failure and production safety accidents caused by improper temperature and pressure adjustments.

[0020] according to Figures 1-2 As shown, the motor 105 and the booster pump 202 are electrically connected to the heating wire 302 and the control panel 108.

[0021] It should be noted that the control panel 108 can control the motor 105 to drive the rotating shaft 106 to rotate, which helps to mix the solution inside the barrel 101 and allows the solution to react better.

[0022] according to Figure 2 As shown, the inside of the control panel 108 is equipped with an information processing module, a data collection module, and a timing module.

[0023] It should be noted that the control panel 108 can reflect the temperature and pressure inside the reaction vessel 301, and the temperature and pressure inside the reaction vessel 301 can be adjusted through the control panel 108 to avoid incomplete reaction and production safety accidents.

[0024] according to Figure 2 As shown, sealing flanges are installed at the connection points between the connecting pipe 5 and the equipment.

[0025] It should be noted that the connecting pipe 5 allows the well-mixed solution to enter the inside of the reaction device 3 and the working tank 401 for reaction and separation, and the sealing flange helps prevent leakage of the solution during the moving reaction process, ensuring stable gas pressure inside the tank.

[0026] The embodiments of the present invention have been described in detail above with reference to the accompanying drawings. However, the present invention is not limited to the above embodiments. Within the scope of knowledge possessed by those skilled in the art, various changes can be made without departing from the spirit of the present invention.

Claims

1. An apparatus for the continuous hydrogenation preparation of relugoli intermediates, characterized in that: It includes a mixing device (1), a connecting pipe (5) fixedly connected to the bottom of the mixing device (1), a lift pump box (2) fixedly connected to the side of the connecting pipe (5) away from the mixing device (1), a reaction device (3) fixedly connected to the side of the lift pump box (2) away from the mixing device (1), and a gas-liquid separation device (4) fixedly connected to the side of the reaction device (3) away from the lift pump box (2). The mixing device (1) includes a barrel (101), a feeding box (102) fixedly connected to the front of the barrel (101), a feeding port (103) opened on the top surface of the feeding box (102), a bracket (104) fixedly connected to the side of the barrel (101), a motor (105) fixedly connected to the top surface of the barrel (101), a rotating shaft (106) fixedly connected to the top surface of the inner side of the barrel (101), a mixing fan (107) fixedly connected to the side of the rotating shaft (106), and a control panel (108) fixedly connected to the front of the feeding box (102). The booster pump box (2) includes a protective box (201) and a booster pump (202) fixedly connected to the inside of the protective box (201). The reaction device (3) includes a reaction vessel (301), a heating wire (302) fixedly connected to the inside of the reaction vessel (301), a temperature sensor (303) fixedly connected to the inside of the reaction vessel (301), and a pressure sensor (304) fixedly connected to the inside of the reaction vessel (301). The gas-liquid separation device (4) includes a working tank (401), a liquid outlet pipe (402) opened on the bottom surface of the working tank (401), and a gas outlet pipe (403) opened on the side surface of the working tank (401).

2. The apparatus for continuous hydrogenation preparation of relugoli intermediates according to claim 1, characterized in that: The barrel (101), connecting pipe (5), and booster pump (202) are connected to the interior of the reaction tank (301) and the working tank (401).

3. The apparatus for continuous hydrogenation preparation of relugoli intermediates according to claim 1, characterized in that: The temperature sensor (303) is model CWDZ11, and the pressure sensor (304) is model CYYZ11.

4. The apparatus for continuous hydrogenation preparation of relugoli intermediates according to claim 1, characterized in that: The motor (105) and the booster pump (202) are electrically connected to the heating wire (302) and the control panel (108).

5. The apparatus for continuous hydrogenation preparation of relugoli intermediates according to claim 1, characterized in that: The control panel (108) is equipped with an information processing module, a data collection module, and a timing module on its inner side.

6. The apparatus for continuous hydrogenation preparation of relugoli intermediates according to claim 1, characterized in that: The connecting pipe (5) is equipped with a sealing flange at the connection point with the equipment.

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