A fermentation device for biopharmaceutical automation processing

Abstract

The utility model discloses a fermentation device for biopharmaceutical automation processing, including support frame still include: stirring subassembly, U -shaped board, flowmeter, pressure -relief valve, thermometer, protective cover, cooling assembly, controller, fermentation cylinder, radar liquid level meter, liquid outlet valve, coiled electric heating wire. The utility model discloses through stirring subassembly, makes solid medicine and liquid medicine fermentation, in the fermentation process, the foam produced in fermentation gradually increases, when radar liquid level meter detects that the foam rises, and stirring subassembly continues to work, makes the foam in fermentation cylinder reduce, avoids the overflow of foam, and the pressure in fermentation cylinder increases, and pressure -relief valve starts automatically, starts to carry out pressure relief, and thermometer detects the temperature in fermentation cylinder, when temperature is lower, through coiled electric heating wire electrification, makes the temperature of fermentation cylinder rise, makes the medicine be completely fermented, when detecting that temperature is higher, through cooling assembly, makes fermentation cylinder cooling, avoids the medicine in fermentation cylinder excessive fermentation.

Description

Technical Field

[0001] This utility model relates to the field of biopharmaceuticals, and more specifically, to a fermentation device for automated biopharmaceutical processing. Background Technology

[0002] Most drugs currently contain organic components, which need to be obtained through microbial fermentation. Therefore, fermentation tanks are used in drug production. Fermentation tanks are devices used for microbial fermentation and can produce organic substances such as antibiotics, amino acids, organic acids, and vitamins.

[0003] Existing fermentation equipment for automated biopharmaceutical processing is prone to incomplete or excessive fermentation of drugs during use, which reduces its practicality.

[0004] Therefore, it is necessary to provide a fermentation apparatus for automated biopharmaceutical processing to solve the above-mentioned technical problems. Utility Model Content

[0005] The purpose of this invention is to address the shortcomings of existing technologies by proposing a fermentation device for automated biopharmaceutical processing.

[0006] This utility model achieves its invention objective using the following technical solution:

[0007] A fermentation device for automated biopharmaceutical processing includes a support frame, and further includes: a stirring assembly, a U-shaped plate, a flow meter, a pressure relief valve, a thermometer, a protective cover, a cooling assembly, a controller, a fermentation cylinder, a radar level gauge, a liquid outlet valve, and a serpentine heating wire.

[0008] The fermentation cylinder is fixedly connected to the upper side of the support frame, the protective cover is fixedly connected to the outer edge of the fermentation cylinder, the stirring assembly for stirring the required fermentation drug is connected to the fermentation cylinder, the cooling assembly for cooling the fermentation drug and the serpentine heating wire for heating are connected to the fermentation cylinder.

[0009] As a further limitation of this technical solution, the stirring assembly includes a motor, which is fixedly connected to the U-shaped plate. The U-shaped plate is fixedly connected to the upper side of the protective cover. The output shaft of the motor passes through the U-shaped plate, and the end of the motor's output shaft is fixedly connected to the center of a large gear. The center of the large gear is fixedly connected to the upper end of a round rod. The two ends of the round rod are movably connected to the two sides of the fermentation tank. The lower part of the round rod is fixedly connected to symmetrical L-shaped scrapers, which are respectively attached to the inner wall of the fermentation tank. The lower end of the round rod is fixedly connected to symmetrical arc-shaped scrapers, and the lower sides of the two arc-shaped scrapers are respectively attached to the lower side of the inner wall of the fermentation tank. The large gear meshes with symmetrical small gears, and the central shafts of the two small gears are movably connected to the upper side of the fermentation tank. The ends of the central shafts of the two small gears are fixedly connected to corresponding rotating rods, and the lower ends of the two rotating rods are fixedly connected to a corresponding set of stirring rods.

[0010] As a further limitation of this technical solution, the cooling component includes a serpentine tube, which is wrapped around the outer wall of the fermentation cylinder. Both ends of the serpentine tube pass through and are fixedly connected to the protective cover. One end of the serpentine tube is fixedly connected to the liquid inlet pipe, and the liquid inlet of the liquid inlet pipe is fixedly connected to the liquid outlet of the liquid pump. The liquid inlet of the liquid pump is fixedly connected to the connecting pipe.

[0011] As a further limitation of this technical solution, the outer wall of the fermentation cylinder is fitted with the serpentine heating wire, and the electrodes at both ends of the serpentine heating wire pass through and are fixedly connected to the protective cover.

[0012] As a further limitation of this technical solution, the lower probe end of the radar level gauge passes through and is fixedly connected to the fermentation tank, the lower probe end of the thermometer passes through and is fixedly connected to the fermentation tank, and the lower part of the pressure relief valve passes through and is fixedly connected to the fermentation tank.

[0013] As a further limitation of this technical solution, the flow meter is fixedly connected to the U-shaped plate, the flow meter is fixedly connected to the L-shaped tube, the L-shaped tube passes through and is fixedly connected to the U-shaped plate, and the lower end of the L-shaped tube is fixedly connected to the fermentation tank.

[0014] As a further limitation of this technical solution, the controller is fixedly connected to one side of the protective cover.

[0015] As a further limitation of this technical solution, the lower side of the fermentation tank is fixedly connected to the liquid outlet valve.

[0016] As a further limitation of this technical solution, the upper side of the fermentation cylinder is fixedly connected to the feed inlet, and the feed inlet is fixedly connected to the inner wall of the feed inlet cover.

[0017] Compared with related technologies, this utility model has the following beneficial effects:

[0018] (1) The stirring assembly enables solid and liquid drugs to ferment better. During the fermentation process, the foam produced by the fermentation gradually increases. When the radar level gauge detects the increase in foam, the controller controls the stirring assembly to continue working, so as to reduce the foam in the fermentation tank and prevent the foam from overflowing. During the fermentation process, the pressure in the fermentation tank increases, and the pressure relief valve is automatically activated to start depressurizing the fermentation tank. The thermometer detects the temperature in the fermentation tank. When the temperature in the fermentation tank is low, the serpentine heating wire is energized to heat the fermentation tank, so that the temperature of the fermentation tank is increased and the drug in the fermentation tank is completely fermented. When the thermometer detects that the temperature in the fermentation tank is high, the cooling assembly is used to cool the fermentation tank to prevent the drug in the fermentation tank from over-fermenting.

[0019] (2) When the fermentation of the drug in the fermentation tank is completed, open the liquid outlet valve to allow the drug in the fermentation tank to be discharged through the liquid outlet valve. During the discharge process, the arc-shaped scraper can push the drug at the bottom of the fermentation tank so that the drug in the fermentation tank can be discharged through the liquid outlet valve better. Attached Figure Description

[0020] Figure 1 This is a three-dimensional structural diagram of the present invention.

[0021] Figure 2 This is a three-dimensional structural diagram of the present invention.

[0022] Figure 3 This is a schematic diagram of the connection structure after some parts of this utility model have been cut apart.

[0023] Figure 4 This is a schematic diagram of the connection structure of some parts of this utility model.

[0024] In the picture:

[0025] 1: Stirring assembly; 11: Motor; 12: Large gear; 13: Small gear; 14: Rotating rod; 15: Round rod; 16: Stirring rod; 17: L-shaped scraper; 18: Arc-shaped scraper.

[0026] 2. U-shaped plate;

[0027] 3: Flow meter, 31, L-shaped tube;

[0028] 4. Pressure relief valve;

[0029] 5. Thermometer;

[0030] 6. Protective cover;

[0031] 7. Support frame;

[0032] 8: Cooling components; 81. Serpentine tube; 82. Liquid inlet pipe; 83. Liquid pump; 84. Connecting pipe;

[0033] 9. Controller;

[0034] 10: Fermentation cylinder; 101: Inlet; 102: Inlet cover;

[0035] 100. Radar level gauge;

[0036] 110. Discharge valve;

[0037] 120. Snake-shaped heating wire. Detailed Implementation

[0038] The present invention will be further described below with reference to the accompanying drawings and embodiments.

[0039] A fermentation device for automated biopharmaceutical processing includes a support frame 7, and further includes: a stirring assembly 1, a U-shaped plate 2, a flow meter 3, a pressure relief valve 4, a thermometer 5, a protective cover 6, a cooling assembly 8, a controller 9, a fermentation tank 10, a radar level gauge 100, a liquid outlet valve 110, and a serpentine heating wire 120.

[0040] The upper side of the support frame 7 is fixedly connected to the fermentation cylinder 10, the outer wall edge of the fermentation cylinder 10 is fixedly connected to the protective cover 6, the stirring assembly 1 for stirring the required fermentation drug is connected to the fermentation cylinder 10, the cooling assembly 8 for cooling the fermentation drug and the serpentine heating wire 120 for heating are connected to the fermentation cylinder 10.

[0041] The stirring assembly 1 includes a motor 11, which is fixedly connected to the U-shaped plate 2. The U-shaped plate 2 is fixedly connected to the upper side of the protective cover 6. The output shaft of the motor 11 passes through the U-shaped plate 2, and the end of the output shaft of the motor 11 is fixedly connected to the center of a large gear 12. The center of the large gear 12 is fixedly connected to the upper end of a round rod 15. The two ends of the round rod 15 are respectively movably connected to the two sides of the fermentation tank 10. The lower part of the round rod 10 is fixedly connected to symmetrical L-shaped scrapers 17. Plates 17 are respectively attached to the inner wall of the fermentation cylinder 10. The lower ends of the round rods 15 are respectively fixedly connected to symmetrical arc-shaped scrapers 18. The lower sides of the two arc-shaped scrapers 18 are respectively attached to the lower side of the inner wall of the fermentation cylinder 10. The large gears 12 respectively mesh with symmetrical small gears 13. The central shafts of the two small gears 13 are respectively movably connected to the upper side of the fermentation cylinder 10. The ends of the central shafts of the two small gears 13 are respectively fixedly connected to corresponding rotating rods 14. The lower ends of the two rotating rods 14 are respectively fixedly connected to a set of corresponding stirring rods 16.

[0042] The cooling component 8 includes a serpentine tube 81, which is wrapped around the outer wall of the fermentation tank 10. Both ends of the serpentine tube 81 pass through and are fixedly connected to the protective cover 6. One end of the serpentine tube 81 is fixedly connected to the liquid inlet pipe 82, and the liquid inlet end of the liquid inlet pipe 82 is fixedly connected to the liquid outlet end of the liquid pump 83. The liquid inlet end of the liquid pump 83 is fixedly connected to the connecting pipe 84.

[0043] The outer wall of the fermentation cylinder 10 is fitted with the serpentine heating wire 120, and the electrodes at both ends of the serpentine heating wire 120 pass through and are fixedly connected to the protective cover 6.

[0044] The lower probe end of the radar level gauge 100 passes through and is fixedly connected to the fermentation tank 10, the lower probe end of the thermometer 5 passes through and is fixedly connected to the fermentation tank 10, and the lower part of the pressure relief valve 4 passes through and is fixedly connected to the fermentation tank 10.

[0045] The flow meter 3 is fixedly connected to the U-shaped plate 2, and the flow meter 3 is fixedly connected to the L-shaped tube 31. The L-shaped tube 31 passes through and is fixedly connected to the U-shaped plate 2, and the lower end of the L-shaped tube 31 is fixedly connected to the fermentation tank 10.

[0046] The controller 9 is fixedly connected to one side of the protective cover 6.

[0047] The lower side of the fermentation tank 10 is fixedly connected to the liquid outlet valve 110.

[0048] The upper side of the fermentation cylinder 10 is fixedly connected to the feed inlet 101, and the feed inlet 101 is fixedly connected to the inner wall of the feed inlet cover 102.

[0049] The serpentine heating wire 120 is electrically connected to the external power supply, and the controller 9 is electrically connected to the motor 11, the flow meter 3, the thermometer 5 and the radar level gauge 100 respectively.

[0050] The wiring diagrams of the controller 9, serpentine heating wire 120, motor 11, flow meter 3, thermometer 5, and radar level gauge 100 in this utility model are common knowledge in the field. Their working principles are known technologies. The appropriate model is selected according to actual use. Therefore, the control method and wiring layout of the wiring diagrams of the controller 9, serpentine heating wire 120, motor 11, flow meter 3, thermometer 5, and radar level gauge 100 will not be explained in detail.

[0051] The working principle is as follows: First, connect the two electrodes of the serpentine heating wire 120 to the external power supply to energize the serpentine heating wire 120. Connect the connecting tube 84 to the external ice water storage device. Connect the other end of the serpentine tube 81 to the ice water storage device. Connect the inlet of the L-shaped tube 31 to the external liquid drug pump. Then, unscrew the feed port cover 102 and add the solid drug to be fermented into the fermentation tank 10 through the feed port 101. Turn on the external liquid drug pump so that the liquid drug enters the fermentation tank 10 through the L-shaped tube 31. When the flow meter 3 detects that the required fermentation drug in the fermentation tank 10 has reached the preset value, turn off the external liquid drug pump and stop adding solid drugs. Then, screw on the feed port cover 102.

[0052] At this time, the solid and liquid drugs in the fermentation tank 10 are fermenting. The controller 9 controls the motor 11 to start, and the motor 11 drives the large gear 12 to rotate. The large gear 12 meshes with two small gears 13 to rotate. The two small gears 13 drive the stirring rods 16 to rotate through the rotating rod 14, so that a set of stirring rods 16 stirs the solid and liquid drugs in the fermentation tank 10. At the same time, the large gear 12 drives the L-shaped scraper 17 and the arc-shaped scraper 18 to rotate through the round rod 15. The L-shaped scraper 17 scrapes off the drugs adhering to the inner wall of the fermentation tank 10, so that the scraped drugs continue to be stirred. The arc-shaped scraper 18 also stirs the drugs at the bottom of the fermentation tank 10, so that the solid and liquid drugs can ferment better. During the fermentation process, the foam produced by the fermentation gradually increases. When the radar level gauge 100 detects the increase in foam, the controller 9 controls the stirring assembly 1 to continue to work, so as to reduce the foam in the fermentation tank 10 and prevent the foam from overflowing the fermentation tank 10. During the fermentation process, the pressure in the fermentation tank 10 increases, and the pressure relief valve 4 is automatically activated to start depressurizing the fermentation tank 10.

[0053] Meanwhile, thermometer 5 detects the temperature inside fermentation tank 10. When the temperature inside fermentation tank 10 is low, the serpentine heating wire 120 is energized to heat fermentation tank 10, raising the temperature of fermentation tank 10 and allowing the drug inside fermentation tank 10 to be fully fermented. When thermometer 5 detects a high temperature inside fermentation tank 10, liquid pump 83 is started, allowing external ice water storage equipment to enter liquid pump 83, inlet pipe 82, and serpentine pipe 81 through connecting pipe 84 to cool fermentation tank 10 and prevent over-fermentation of the drug inside fermentation tank 10.

[0054] When the fermentation of the drug in the fermentation tank 10 is completed, the liquid outlet valve 110 is opened to allow the drug in the fermentation tank 10 to be discharged through the liquid outlet valve 110. During the discharge process, the arc-shaped scraper 18 can push the drug at the bottom of the fermentation tank 10 so that the drug in the fermentation tank 10 can be discharged through the liquid outlet valve 110 better.

[0055] Compared with related technologies, this utility model has the following beneficial effects: The stirring assembly 1 enables better fermentation of solid and liquid drugs. During fermentation, the foam produced gradually increases. When the radar level gauge 100 detects an increase in foam, the controller 9 controls the stirring assembly 1 to continue working, reducing the foam in the fermentation tank 10 and preventing foam overflow. During fermentation, the pressure inside the fermentation tank 10 increases, and the pressure relief valve 4 automatically activates to release pressure from the fermentation tank 10. The thermometer 5 detects the temperature inside the fermentation tank 10. When the temperature inside the fermentation tank 10 is low, the serpentine heating wire 120 is energized to heat the fermentation tank 10, raising its temperature and ensuring complete fermentation of the drugs within. When the thermometer 5 detects a high temperature inside the fermentation tank 10, the cooling assembly 8 cools the fermentation tank 10, preventing over-fermentation of the drugs within.

[0056] The above description is merely an embodiment of this utility model and does not limit the patent scope of this utility model. Any equivalent structural or procedural transformations made based on the content of this utility model specification and drawings, or direct or indirect applications in other related technical fields, are similarly included within the patent protection scope of this utility model.

Claims

1. A fermentation apparatus for automated biopharmaceutical processing, comprising a support frame (7), characterized in that, The fermentation unit for automated biopharmaceutical processing also includes: Stirring assembly (1), U-shaped plate (2), flow meter (3), pressure relief valve (4), thermometer (5), protective cover (6), cooling assembly (8), controller (9), fermentation tank (10), radar level gauge (100), liquid outlet valve (110), serpentine heating wire (120); The upper side of the support frame (7) is fixedly connected to the fermentation cylinder (10), the outer wall edge of the fermentation cylinder (10) is fixedly connected to the protective cover (6), the stirring assembly (1) for stirring the required fermentation drug is connected to the fermentation cylinder (10), the cooling assembly (8) for cooling the fermentation drug and the serpentine heating wire (120) for heating are connected to the fermentation cylinder (10).

2. The fermentation apparatus for automated biopharmaceutical processing according to claim 1, characterized in that: The stirring assembly (1) includes a motor (11), which is fixedly connected to the U-shaped plate (2). The U-shaped plate (2) is fixedly connected to the upper side of the protective cover (6). The output shaft of the motor (11) passes through the U-shaped plate (2). The end of the output shaft of the motor (11) is fixedly connected to the center of a large gear (12). The center of the large gear (12) is fixedly connected to the upper end of a round rod (15). The two ends of the round rod (15) are respectively movably connected to the two sides of the fermentation tank (10). The lower part of the round rod (15) is fixedly connected to symmetrical L-shaped scrapers (17). The shaped scrapers (17) are respectively attached to the inner wall of the fermentation cylinder (10), and the lower end of the round rod (15) is respectively fixedly connected to the symmetrical arc-shaped scrapers (18). The lower sides of the two arc-shaped scrapers (18) are respectively attached to the lower side of the inner wall of the fermentation cylinder (10). The large gear (12) respectively meshes with the symmetrical small gears (13). The central shafts of the two small gears (13) are respectively movably connected to the upper side of the fermentation cylinder (10). The ends of the central shafts of the two small gears (13) are respectively fixedly connected to the corresponding rotating rods (14). The lower ends of the two rotating rods (14) are respectively fixedly connected to a set of stirring rods (16).

3. The fermentation apparatus for automated biopharmaceutical processing according to claim 2, characterized in that: The cooling component (8) includes a serpentine tube (81) which surrounds the outer wall of the fermentation tank (10). Both ends of the serpentine tube (81) pass through and are fixedly connected to the protective cover (6). One end of the serpentine tube (81) is fixedly connected to the liquid inlet pipe (82). The liquid inlet end of the liquid inlet pipe (82) is fixedly connected to the liquid outlet end of the liquid pump (83). The liquid inlet end of the liquid pump (83) is fixedly connected to the connecting pipe (84).

4. The fermentation apparatus for automated biopharmaceutical processing according to claim 3, characterized in that: The outer wall of the fermentation cylinder (10) is fitted with the serpentine heating wire (120), and the electrodes at both ends of the serpentine heating wire (120) pass through and are fixedly connected to the protective cover (6).

5. The fermentation apparatus for automated biopharmaceutical processing according to claim 1, characterized in that: The lower probe end of the radar level gauge (100) passes through and is fixedly connected to the fermentation tank (10), the lower probe end of the thermometer (5) passes through and is fixedly connected to the fermentation tank (10), and the lower part of the pressure relief valve (4) passes through and is fixedly connected to the fermentation tank (10).

6. The fermentation apparatus for automated biopharmaceutical processing according to claim 1, characterized in that: The flow meter (3) is fixedly connected to the U-shaped plate (2), the flow meter (3) is fixedly connected to the L-shaped tube (31), the L-shaped tube (31) passes through and is fixedly connected to the U-shaped plate (2), and the lower end of the L-shaped tube (31) is fixedly connected to the fermentation tank (10).

7. The fermentation apparatus for automated biopharmaceutical processing according to claim 1, characterized in that: The controller (9) is fixedly connected to one side of the protective cover (6).

8. The fermentation apparatus for automated biopharmaceutical processing according to claim 1, characterized in that: The lower side of the fermentation tank (10) is fixedly connected to the liquid outlet valve (110).

9. The fermentation apparatus for automated biopharmaceutical processing according to claim 1, characterized in that: The upper side of the fermentation cylinder (10) is fixedly connected to the feed inlet (101), and the feed inlet (101) is fixedly connected to the inner wall of the feed inlet cover (102).

Images