A microfluidic co-flow merging device

Abstract

The utility model discloses to the problem of poor mixing efficiency of the existing passive micro-mixer, disclose a kind of microfluidic parallel flow intermingling device, by being provided with the first liquid inlet cavity and the second liquid inlet cavity in parallel in device, further can realize two different fluids in intermingling channel carry out parallel type intermixing, under micro size, the contact area between two fluids can be significantly increased, further greatly improve the efficiency of fluid mutual penetration mixing.Further still the first liquid inlet cavity and the second liquid inlet cavity are designed as half-enclosing or fully-enclosing parallel structure, so that two different fluid flow into intermingling channel is the state of mutual dispersion coating, further increase the contact area between two fluids and greatly improve the efficiency of two intermingling.In addition, the microfluidic parallel flow intermingling device also has the advantages of simple structure, easy operation.

Description

Technical Field

[0001] This utility model relates to fluid mixing equipment, specifically to a microfluidic parallel flow and fusion device, belonging to the technical field of microfluidic mixing equipment. Background Technology

[0002] Microfluidics is a technology for manipulating fluids at the microscale. Micromixers are a key component of microfluidic systems, used to improve the efficiency of fluid mixing and blending at the microscale. Since mixing at low Reynolds numbers relies on molecular diffusion, traditional stirring is difficult to achieve. Typical applications include chemical synthesis, nanoparticle preparation, and single-cell analysis; their high-efficiency mixing capabilities can significantly shorten reaction times and improve system efficiency.

[0003] Micromixers are divided into active mixers and passive mixers. Active mixers are complex in structure and difficult to manufacture, resulting in high costs and limited industrial applications. Passive micromixers currently mostly use T-type mixers, which, although simple in structure, have poor mixing efficiency. Some fluid mixers also attempt to improve mixing efficiency by using abrupt changes in the pipeline or built-in obstructions, but the improvement is limited, and they suffer from significant clogging problems when used in microfluidic systems for precipitation reactions. Utility Model Content

[0004] This invention addresses the problem of poor mixing efficiency in existing passive micromixers by providing a microfluidic parallel flow mixing device. By setting up a first inlet chamber and a second inlet chamber that are arranged in parallel, the two different fluids flow out from the outlets of the different inlet chambers and then mix in a parallel manner in the mixing channel. Under micro-scale conditions, the contact area between the two fluids is significantly increased, thereby greatly improving the efficiency of fluid mutual penetration and mixing.

[0005] To achieve the above-mentioned technical objectives, the technical solution adopted by this utility model is as follows:

[0006] A microfluidic co-flow fusion device includes a first inlet pipe, a second inlet pipe, a co-flow chamber, and a fusion channel. A partition is disposed within the inner cavity of the co-flow chamber, dividing the cavity into a first inlet chamber and a second inlet chamber arranged side-by-side. The first inlet pipe is connected to the inlet of the first inlet chamber. The second inlet pipe is connected to the inlet of the second inlet chamber. The outlets of both the first and second inlet chambers are connected to the inlet of the fusion channel.

[0007] Preferably, the partition is a tubular annular plate. The top end of the tubular annular plate is connected to the top wall of the co-flow chamber, and the bottom end is connected to the fusion channel. The inner cavity of the tubular annular plate forms a first inlet chamber, and a first inlet pipe penetrates the top wall of the co-flow chamber and connects to the first inlet chamber. The outer wall of the tubular annular plate and the inner wall of the co-flow chamber form a second inlet chamber, and a second inlet pipe penetrates the top wall and / or side wall of the co-flow chamber and connects to the second inlet chamber. Preferably, the second inlet chamber is an annular clamping cavity.

[0008] Preferably, the inner diameter of the first liquid inlet chamber is 0.1 to 0.9 times the inner diameter of the parallel flow chamber, more preferably 0.2 to 0.8 times, and even more preferably 0.3 to 0.7 times.

[0009] Preferably, the axial length of the first inlet chamber is less than the axial length of the second inlet chamber. A sealing plate is provided at the bottom of the first inlet chamber. An outlet communicating with the fusion channel is provided on the bottom wall of the second inlet chamber. At least one flow tube communicating with the first inlet chamber is provided through the sealing plate, and the bottom end of the flow tube extends downward into the outlet of the second inlet chamber.

[0010] Preferably, the axial distance between the bottom end of the first liquid inlet chamber and the bottom wall of the second liquid inlet chamber is 0.1 to 0.5 times the axial length of the second liquid inlet chamber, preferably 0.15 to 0.4 times, and more preferably 0.2 to 0.3 times.

[0011] Preferably, the microfluidic co-flow fusion device includes multiple second inlet pipes, which are evenly distributed circumferentially along the sidewall of the co-flow chamber.

[0012] Preferably, the second inlet pipe intersects the side wall of the parallel flow chamber perpendicularly or obliquely. More preferably, the second inlet pipe intersects the side wall of the parallel flow chamber obliquely with an oblique angle of 5 to 55°, more preferably 8 to 50°, and more preferably 10 to 45°.

[0013] Preferably, the axis of the first inlet pipe is perpendicular to the axis of the second inlet pipe in space.

[0014] Preferably, the fusion channel is a tapered pipe with a wide inlet and a narrow outlet. Preferably, the inlet diameter of the fusion channel is not less than the outer diameter of the first inlet chamber, and the outlet diameter of the fusion channel is 0.1 to 0.8 times its inlet diameter, more preferably 0.3 to 0.5 times.

[0015] Preferably, the microfluidic co-flow fusion device further includes a bubble input pipe, which is disposed on the side wall of the fusion channel near the outlet of the fusion channel and is connected to the interior of the fusion channel.

[0016] In this invention, the microfluidic co-flow fusion device mainly includes inlet pipes (first inlet pipe and second inlet pipe) for supplying different fluids and a mixing body (co-flow chamber and fusion channel) for supplying different fluids for fusion. The mixing body is divided into two parallel inlet chambers (i.e., first inlet chamber and second inlet chamber, which together constitute the co-flow chamber). Different fluids to be mixed are first transported to different inlet chambers through different inlet pipes, and then discharged simultaneously from the outlets of different inlet chambers in a parallel flow manner. Since the outlets of different inlet chambers are connected to the inlet of the mixing channel and are arranged side by side, during the process of different fluids being discharged from the inlet chambers to the mixing channel at the same time, the fluids mix with adjacent fluids due to self-diffusion after exiting the outlet of the inlet chamber. This causes the different fluids to flow forward and mix in the mixing channel in an approximately parallel flow manner. Compared with the convection collision mixing of conventional T-type mixers, the contact area between different fluids is significantly increased in the parallel flow (also known as quasi-parallel) mixing of this invention, thereby greatly improving the efficiency of mutual penetration and mixing between different fluids.

[0017] In this invention, the first and second inlet chambers are separated by a tubular annular plate. Specifically, the first inlet chamber is a tubular cavity formed between the inner wall of the tubular annular plate and the top wall of the co-flow chamber, while the second inlet chamber is a clamping cavity (preferably an annular clamping cavity) formed between the outer wall of the tubular annular plate and the side wall of the co-flow chamber. In other words, the first and second inlet chambers are arranged in parallel with each other, either semi-enclosed (in this invention, this refers to the case where their axes are parallel) or coaxially enclosed (preferably coaxially enclosed). Specifically, the first inlet pipe penetrates the top wall of the co-flow chamber and connects to the first inlet chamber, while the second inlet pipe penetrates the top wall and / or side wall (preferably the side wall) of the co-flow chamber and connects to the second inlet chamber. This invention designs the first and second inlet chambers as semi-enclosed or coaxially fully enclosed side-by-side. When two different fluids flow into the mixing channel from the first and second inlet chambers respectively, the fluid flowing out of the second inlet chamber covers the outside of the fluid flowing out of the first inlet chamber in a semi-enclosed or fully enclosed manner, thereby significantly increasing the mixing contact area between the two fluids and improving the mixing efficiency.

[0018] In this invention, in a preferred embodiment, the axial length of the first inlet chamber is designed to be less than the axial length of the second inlet chamber along the axial direction of the fusion channel. A sealing plate is provided at the bottom of the first inlet chamber. The inlet of the fusion channel extends upward through the bottom wall of the second inlet chamber and is located below the sealing plate (i.e., the outlet of the second inlet chamber is located on the bottom wall of the second inlet chamber below the sealing plate). The sealing plate has several through-type flow pipes for connecting the first inlet chamber and the fusion channel (it should be noted that the flow pipes are evenly distributed within the circular surface of the sealing plate). That is, the fluid in the first inlet chamber flows into the fusion channel in the form of multiple small, non-contacting fluids through the several flow pipes. At the same time, the fluid in the second inlet chamber flows into the fusion channel through the gaps reserved between the several flow pipes. This ensures that the outer periphery of each small fluid flowing out of the first inlet chamber is surrounded by the fluid flowing out of the second inlet chamber, significantly increasing the contact area between the two different fluids within a small size.

[0019] In this invention, the second inlet pipe intersects the side wall of the parallel flow chamber either perpendicularly or obliquely (oblique intersection refers to perpendicular intersection; taking the axis of the second inlet pipe at the point of perpendicular intersection as the initial 0°, then when the axis of the second inlet pipe shifts relative to the initial 0°, it becomes an oblique intersection, and the oblique angle is denoted as α). Figure 12 As shown, α is 5–55°. When the second inlet pipe intersects the side wall of the co-flow chamber at an angle, the fluid flowing into the second inlet pipe will form a spiral flow within the second inlet chamber, which can increase laminar shear and chaotic convection between different fluids, thereby improving the mixing efficiency. In a preferred embodiment, multiple second inlet pipes can be arranged circumferentially along the outer wall of the co-flow chamber. These multiple second inlet pipes can either introduce the same fluid or different fluids. In other words, the microfluidic co-flow mixing device of this invention can achieve efficient mixing between two or more fluids according to actual working conditions.

[0020] In this invention, to further improve the mixing efficiency between different fluids, the mixing channel is designed as a tapered pipe with a wide inlet and a narrow outlet. When different fluids enter the mixing channel simultaneously, they first undergo diffusion mixing at the inlet (where the inlet diameter is larger). Then, as the diameter of the mixing channel decreases, compression mixing is further promoted between the different fluids. This alternating "expansion and contraction" mixing further improves the mixing efficiency. Furthermore, a bubble input pipe is installed on the side wall of the mixing channel near its outlet. High-frequency gas is generated by an air bubble device and enters the mixing channel through the bubble input pipe. The high-frequency gas can isolate the mixed fluid into small droplets. The mixed fluid in the droplet state can be more precisely controlled, resulting in higher reaction efficiency and providing a foundation for the mixed fluid to enter the reactor for efficient reaction.

[0021] In this invention, the diameter of the first inlet pipe is 0.1–50 mm, preferably 0.3–40 mm, and more preferably 0.5–30 mm. The diameter of the second inlet pipe is 0.1–50 mm, preferably 0.3–40 mm, and more preferably 0.5–30 mm. The inlet diameter of the fusion channel is 10–100 mm, preferably 20–80 mm, and more preferably 30–50 mm. The outlet diameter of the fusion channel is 1–60 mm, preferably 3–50 mm, and more preferably 5–40 mm.

[0022] Compared with the prior art, the beneficial technical effects of this utility model are as follows:

[0023] 1: This utility model, through the parallel arrangement of the first and second liquid inlet chambers, enables two different fluids to be mixed in a parallel manner in the mixing channel. Under micro-sized conditions, it can significantly increase the contact area between the two fluids, thereby greatly improving the efficiency of fluid mutual penetration and mixing.

[0024] 2: The present invention further designs the first liquid inlet chamber and the second liquid inlet chamber as a semi-enclosed or fully enclosed parallel structure, so that when the two different fluids flow into the fusion channel, they are in a state of mutual dispersion and coverage, thereby further increasing the contact area between the two fluids and greatly improving the efficiency of their fusion.

[0025] 3: Through a special structural design, this utility model significantly improves the fusion efficiency of the passive microfluidic co-flow mixing device compared to the existing passive T-type mixer, and has the advantages of simple structure and easy operation. Attached Figure Description

[0026] Figure 1 This is a three-dimensional structural diagram of the microfluidic co-flow fusion device of this utility model.

[0027] Figure 2 This is a front view structural schematic diagram of the microfluidic co-flow fusion device of this utility model.

[0028] Figure 3 This is a top view of the microfluidic co-flow fusion device of this utility model.

[0029] Figure 4 This is a schematic diagram of the planar structure of the EE section.

[0030] Figure 5 This is a schematic diagram of the three-dimensional structure of the EE section.

[0031] Figure 6 This is a schematic diagram of the planar structure of the FF section.

[0032] Figure 7 This is a schematic diagram of the planar structure of section BB.

[0033] Figure 8 This is a schematic diagram of the planar structure of the CC section.

[0034] Figure 9 This is a schematic diagram of the planar structure of section DD.

[0035] Figure 10 This is a schematic diagram of the planar structure of section JJ.

[0036] Figure 11 This is a schematic diagram of the planar structure of section KK.

[0037] Figure 12 This is a schematic diagram of the cross-sectional structure of the microfluidic parallel flow fusion device of this utility model when it has multiple second liquid inlet pipes.

[0038] Figure 13 This is a schematic diagram of the cross-sectional structure of the microfluidic co-flow fusion device of this utility model when it has a bubble input pipe.

[0039] Reference numerals in the attached drawings: 1: First inlet pipe; 2: Second inlet pipe; 3: Parallel flow chamber; 301: Baffle plate; 302: First inlet cavity; 303: Second inlet cavity; 304: Sealing plate; 305: Flow pipe; 4: Fusion channel; 5: Bubble input pipe. Detailed Implementation

[0040] The technical solution of this utility model is illustrated below. The scope of protection of this utility model includes, but is not limited to, the following embodiments.

[0041] A microfluidic co-flow fusion device includes a first inlet pipe 1, a second inlet pipe 2, a co-flow chamber 3, and a fusion channel 4. A partition 301 is disposed within the inner cavity of the co-flow chamber 3, dividing the inner cavity of the co-flow chamber 3 into a first inlet chamber 302 and a second inlet chamber 303 arranged side-by-side. The first inlet pipe 1 is connected to the inlet of the first inlet chamber 302. The second inlet pipe 2 is connected to the inlet of the second inlet chamber 303. The outlets of both the first inlet chamber 302 and the second inlet chamber 303 are connected to the inlet of the fusion channel 4.

[0042] Preferably, the partition 301 is a tubular annular plate. The top end of the tubular annular plate is connected to the top wall of the co-flow chamber 3, and the bottom end of the tubular annular plate is connected to the fusion channel 4. The inner cavity of the tubular annular plate forms a first liquid inlet chamber 302, and the first liquid inlet pipe 1 penetrates the top wall of the co-flow chamber 3 and is connected to the first liquid inlet chamber 302. The outer wall of the tubular annular plate and the inner wall of the co-flow chamber 3 form a second liquid inlet chamber 303, and the second liquid inlet pipe 2 penetrates the top wall and / or side wall of the co-flow chamber 3 and is connected to the second liquid inlet chamber 303. Preferably, the second liquid inlet chamber 303 is an annular clamping cavity.

[0043] Preferably, the inner diameter of the first liquid inlet chamber 302 is 0.1 to 0.9 times the inner diameter of the parallel flow chamber 3, more preferably 0.2 to 0.8 times, and even more preferably 0.3 to 0.7 times.

[0044] Preferably, the axial length of the first inlet chamber 302 is less than the axial length of the second inlet chamber 303. A sealing plate 304 is provided at the bottom of the first inlet chamber 302. An outlet communicating with the fusion channel 4 is provided on the bottom wall of the second inlet chamber 303. At least one flow pipe 305 communicating with the first inlet chamber 302 is provided through the sealing plate 304, and the bottom end of the flow pipe 305 extends downward into the outlet of the second inlet chamber 303.

[0045] Preferably, the axial distance between the bottom end of the first liquid inlet chamber 302 and the bottom wall of the second liquid inlet chamber 303 is 0.1 to 0.5 times the axial length of the second liquid inlet chamber 303, preferably 0.15 to 0.4 times, and more preferably 0.2 to 0.3 times.

[0046] Preferably, the microfluidic co-flow fusion device includes multiple second inlet pipes 2, which are evenly distributed circumferentially along the side wall of the co-flow chamber 3.

[0047] Preferably, the second inlet pipe 2 intersects the side wall of the parallel flow chamber 3 perpendicularly or obliquely, and preferably the second inlet pipe 2 intersects the side wall of the parallel flow chamber 3 obliquely with an oblique angle of 5 to 55°.

[0048] Preferably, the axis of the first inlet pipe 1 is perpendicular to the axis of the second inlet pipe 2 in space.

[0049] Preferably, the fusion channel 4 is a tapered pipe with a wide inlet and a narrow outlet. Preferably, the inlet diameter of the fusion channel 4 is not less than the outer diameter of the first liquid inlet chamber 302, and the outlet diameter of the fusion channel 4 is 0.1 to 0.8 times its inlet diameter, more preferably 0.3 to 0.5 times.

[0050] Preferably, the microfluidic co-flow fusion device further includes a bubble input pipe 5, which is disposed on the side wall of the fusion channel 4 near the outlet of the fusion channel 4 and is connected to the interior of the fusion channel 4.

[0051] Example 1

[0052] like Figure 1-13 As shown, a microfluidic co-flow fusion device includes a first inlet pipe 1, a second inlet pipe 2, a co-flow chamber 3, and a fusion channel 4. A partition 301 is disposed within the inner cavity of the co-flow chamber 3, dividing the inner cavity of the co-flow chamber 3 into a first inlet chamber 302 and a second inlet chamber 303 arranged side-by-side. The first inlet pipe 1 is connected to the inlet of the first inlet chamber 302. The second inlet pipe 2 is connected to the inlet of the second inlet chamber 303. The outlets of both the first inlet chamber 302 and the second inlet chamber 303 are connected to the inlet of the fusion channel 4.

[0053] Example 2

[0054] The embodiment 1 is repeated, except that the partition 301 is a tubular annular plate. The top end of the tubular annular plate is connected to the top wall of the co-flow chamber 3, and the bottom end of the tubular annular plate is connected to the fusion channel 4. The inner cavity of the tubular annular plate forms a first liquid inlet chamber 302, and the first liquid inlet pipe 1 penetrates the top wall of the co-flow chamber 3 and is connected to the first liquid inlet chamber 302. The outer wall of the tubular annular plate and the inner wall of the co-flow chamber 3 form a second liquid inlet chamber 303, and the second liquid inlet pipe 2 penetrates the top wall and / or side wall of the co-flow chamber 3 and is connected to the second liquid inlet chamber 303. Preferably, the second liquid inlet chamber 303 is an annular clamping cavity.

[0055] Example 3

[0056] Repeat Example 2, except that the inner diameter of the first liquid inlet chamber 302 is 0.5 times the inner diameter of the parallel flow chamber 3.

[0057] Example 4

[0058] Repeat Example 2, except that the inner diameter of the first liquid inlet chamber 302 is 0.3 times the inner diameter of the parallel flow chamber 3.

[0059] Example 5

[0060] Example 4 is repeated, except that the axial length of the first inlet chamber 302 is less than the axial length of the second inlet chamber 303. A sealing plate 304 is provided at the bottom of the first inlet chamber 302. An outlet communicating with the fusion channel 4 is provided on the bottom wall of the second inlet chamber 303. At least one flow pipe 305 communicating with the first inlet chamber 302 is provided through the sealing plate 304, and the bottom end of the flow pipe 305 extends downward into the outlet of the second inlet chamber 303.

[0061] Example 6

[0062] Repeat Example 5, except that the axial distance between the bottom end of the first liquid inlet chamber 302 and the bottom wall of the second liquid inlet chamber 303 is 0.3 times the axial length of the second liquid inlet chamber 303.

[0063] Example 7

[0064] Repeat Example 5, except that the axial distance between the bottom end of the first liquid inlet chamber 302 and the bottom wall of the second liquid inlet chamber 303 is 0.4 times the axial length of the second liquid inlet chamber 303.

[0065] Example 8

[0066] Repeat Example 7, except that the microfluidic co-flow fusion device includes multiple second inlet pipes 2, which are evenly distributed circumferentially along the side wall of the co-flow chamber 3.

[0067] Example 9

[0068] Repeat Example 8, except that the second inlet pipe 2 intersects the side wall of the parallel flow chamber 3 vertically or obliquely, preferably the second inlet pipe 2 intersects the side wall of the parallel flow chamber 3 obliquely with an oblique angle of 30°.

[0069] Example 10

[0070] Repeat Example 8, except that the second inlet pipe 2 intersects the side wall of the parallel flow chamber 3 vertically or obliquely, preferably the second inlet pipe 2 intersects the side wall of the parallel flow chamber 3 obliquely with an oblique angle of 45°.

[0071] Example 11

[0072] Example 10 is repeated, except that the axis of the first inlet pipe 1 and the axis of the second inlet pipe 2 are spatially perpendicular to each other.

[0073] Example 12

[0074] Repeat Example 11, except that the fusion channel 4 is a tapered pipe with a wide inlet and a narrow outlet.

[0075] Example 13

[0076] Repeat Example 12, except that the inlet diameter of the fusion channel 4 is not less than the outer diameter of the first liquid inlet chamber 302, and the outlet diameter of the fusion channel 4 is 0.8 times its inlet diameter.

[0077] Example 14

[0078] Repeat Example 12, except that the inlet diameter of the fusion channel 4 is not less than the outer diameter of the first liquid inlet chamber 302, and the outlet diameter of the fusion channel 4 is 0.4 times its inlet diameter.

[0079] Example 15

[0080] Repeat Example 14, except that the microfluidic co-flow fusion device also includes a bubble input pipe 5, which is located on the side wall of the fusion channel 4 near the outlet of the fusion channel 4 and is connected to the interior of the fusion channel 4.

[0081] The microfluidic co-flow fusion device of this utility model is used as follows: A first type of fluid is transported from the first inlet pipe 1 to the first inlet chamber 302 of the co-flow chamber 3, while a second type of fluid is transported from the second inlet pipe 2 to the second inlet chamber 303 of the co-flow chamber 3; then, the first type of fluid in the first inlet chamber 302 is diverted into multiple small streams of fluid through the multiple flow pipes 305 on the sealing plate 304 and enters the fusion channel 4, while the second type of fluid in the second inlet chamber 303 passes through the space reserved between the outer walls of the multiple flow pipes 305. The fluid flows into the mixing channel 4 through a gap, and during this process, the multiple streams of the first fluid flowing out of the multiple flow pipes 305 are coated and mixed. When the two fluids enter the mixing channel 4, the diameter of the mixing channel 4 gradually decreases, thereby enhancing the mixing efficiency between the two fluids. Furthermore, high-frequency gas is also supplied to the mixing channel 4 from the outlet through the bubble input pipe 5, thereby further improving the mixing efficiency between the two fluids. The mixed fluid after uniform mixing is discharged from the outlet of the mixing channel 4 for subsequent processing.

[0082] Application Example 1

[0083] The microfluidic co-flow mixing device described in Example 15 was used to mix FeSO4 solution and NaOH-NaNO3 mixed solution. The concentration of FeSO4 solution was 0.2 mol / L; the concentration of NaOH solution in the NaOH-NaNO3 mixed solution was 2.0 mol / L, and the concentration of NaNO3 was 0.5 mol / L. The microfluidic co-flow mixing device was first placed in an 80°C constant temperature water bath. Then, the FeSO4 solution was introduced into the first inlet chamber 302 through the first inlet pipe 1 at a flow rate of 2 mL / min, while the NaOH-NaNO3 mixed solution was introduced into the second inlet chamber 303 through the second inlet pipe 2 at a flow rate of 2 mL / min (the first inlet pipe 1...). The diameter and length of the second inlet pipe 2 are the same, and the volumes of the first inlet chamber 302 and the second inlet chamber 303 are the same. After the mixed fluid is stably discharged from the outlet of the mixing channel 4, it flows into the coil microfluidic reactor for reaction. The reactor is placed in an 80°C constant temperature water bath. The lengths of the coil reactors are set to 1m, 4m, and 7m, respectively. After the solution flows out of the reaction coil, the mixed fluid from different coil reactors is sampled and tested. The iron content in the solid generated by the reaction of the mixed fluid obtained from each sampling is approximately 22.3%, 40.5%, and 64.1%, respectively.

[0084] Comparative Example 1

[0085] A conventional horizontal counter-current mixing T-type mixer (including a horizontal tube and a vertical tube perpendicularly connected to the middle of the horizontal tube, the vertical tube having a diameter twice that of the horizontal tube) was used to mix FeSO4 solution and NaOH-NaNO3 mixed solution, wherein: the concentration of FeSO4 solution was 0.2 mol / L; the concentration of NaOH solution in the NaOH-NaNO3 mixed solution was 2.0 mol / L, and the concentration of NaNO3 was 0.5 mol / L; the T-type mixer was first placed in an 80℃ constant temperature water bath, and then the FeSO4 solution and NaOH-NaNO3 mixture were mixed. 3. The mixed solutions were simultaneously introduced from both ends of a horizontal tube at a flow rate of 2 mL / min, and discharged through a vertical tube after converging. After the mixed fluid was stably discharged from the outlet of the vertical tube, it flowed into a coiled microfluidic reactor for reaction. The reactor was placed in an 80℃ constant temperature water bath. The lengths of the coiled reactors were set to 1m, 4m, and 7m, respectively. After the solution flowed out of the reaction coil, samples of the mixed fluid from different coiled reactors were taken for testing. The iron content in the solid generated by the reaction of the mixed fluid obtained from each sampling was approximately 10.4%, 19.7%, and 45.3%, respectively.

[0086] Comparative Example 2

[0087] A conventional vertical counter-current mixing T-type mixer (including a horizontal tube, a vertical tube, and an outlet tube; one end of the horizontal tube intersects and connects perpendicularly to one end of the vertical tube; the outlet tube is coaxial with the horizontal tube and connected to both the horizontal and vertical tubes; the diameter of the horizontal tube is the same as that of the vertical tube, and the diameter of the outlet tube is twice that of the horizontal tube) was used to mix FeSO4 solution and NaOH-NaNO3 mixed solution, wherein: the concentration of FeSO4 solution is 0.2 mol / L; the concentration of NaOH solution in the NaOH-NaNO3 mixed solution is 2.0 mol / L, and the concentration of NaNO3 is 0.5 mol / L; the T-type mixer was first placed at 8 In a 0℃ constant temperature water bath, FeSO4 solution and NaOH-NaNO3 mixed solution were simultaneously introduced from a horizontal pipe and a vertical pipe at a flow rate of 2 mL / min, respectively. After they converged, they were discharged through an outlet pipe. After the mixed fluid was stably discharged from the outlet pipe, it flowed into a coil microfluidic reactor for reaction. The reactor was also placed in an 80℃ constant temperature water bath. The lengths of the coil reactors were set to 1m, 4m, and 7m, respectively. After the solution flowed out of the reaction coil, samples of the mixed fluid from different coil reactors were taken for testing. The iron content in the solid generated by the reaction of the mixed fluid obtained from each sampling was 9.4%, 18.9%, and 43.6%, respectively.

Claims

1. A microfluidic co-flow fusion device, characterized in that: The microfluidic co-flow fusion device includes a first inlet pipe (1), a second inlet pipe (2), a co-flow chamber (3), and a fusion channel (4); a partition (301) is provided in the inner cavity of the co-flow chamber (3), which divides the inner cavity of the co-flow chamber (3) into a first inlet chamber (302) and a second inlet chamber (303) that are parallel to each other; the first inlet pipe (1) is connected to the inlet of the first inlet chamber (302); the second inlet pipe (2) is connected to the inlet of the second inlet chamber (303); the outlets of the first inlet chamber (302) and the second inlet chamber (303) are both connected to the inlet of the fusion channel (4).

2. The microfluidic co-flow fusion device according to claim 1, characterized in that: The partition (301) is a tubular ring plate; the top end of the tubular ring plate is connected to the top wall of the parallel flow chamber (3), and the bottom end of the tubular ring plate is connected to the fusion channel (4); the inner cavity of the tubular ring plate forms a first liquid inlet chamber (302), and the first liquid inlet pipe (1) passes through the top wall of the parallel flow chamber (3) and is connected to the first liquid inlet chamber (302); the outer wall of the tubular ring plate and the inner wall of the parallel flow chamber (3) form a second liquid inlet chamber (303), and the second liquid inlet pipe (2) passes through the top wall and / or side wall of the parallel flow chamber (3) and is connected to the second liquid inlet chamber (303).

3. The microfluidic co-flow fusion device according to claim 2, characterized in that: The second liquid inlet chamber (303) is an annular clamping chamber.

4. The microfluidic co-flow fusion device according to claim 2, characterized in that: The inner diameter of the first liquid inlet chamber (302) is 0.1 to 0.9 times the inner diameter of the parallel flow chamber (3).

5. The microfluidic co-flow fusion device according to claim 4, characterized in that: The inner diameter of the first liquid inlet chamber (302) is 0.2 to 0.8 times the inner diameter of the parallel flow chamber (3).

6. The microfluidic co-flow fusion device according to claim 5, characterized in that: The inner diameter of the first liquid inlet chamber (302) is 0.3 to 0.7 times the inner diameter of the parallel flow chamber (3).

7. The microfluidic co-flow fusion device according to claim 2, characterized in that: The axial length of the first liquid inlet chamber (302) is less than the axial length of the second liquid inlet chamber (303); a sealing plate (304) is provided at the bottom of the first liquid inlet chamber (302); an outlet connected to the fusion channel (4) is provided on the bottom wall of the second liquid inlet chamber (303); at least one flow pipe (305) connected to the first liquid inlet chamber (302) is provided through the sealing plate (304), and the bottom end of the flow pipe (305) extends downward to the outlet of the second liquid inlet chamber (303).

8. The microfluidic co-flow fusion device according to claim 7, characterized in that: The axial distance between the bottom end of the first liquid inlet chamber (302) and the bottom wall of the second liquid inlet chamber (303) is 0.1 to 0.5 times the axial length of the second liquid inlet chamber (303).

9. The microfluidic co-flow fusion device according to claim 8, characterized in that: The axial distance between the bottom end of the first liquid inlet chamber (302) and the bottom wall of the second liquid inlet chamber (303) is 0.15 to 0.4 times the axial length of the second liquid inlet chamber (303).

10. The microfluidic co-flow fusion device according to claim 9, characterized in that: The axial distance between the bottom end of the first liquid inlet chamber (302) and the bottom wall of the second liquid inlet chamber (303) is 0.2 to 0.3 times the axial length of the second liquid inlet chamber (303).

11. The microfluidic co-flow fusion device according to claim 2, characterized in that: The microfluidic parallel flow fusion device includes multiple second inlet pipes (2), which are evenly distributed along the circumference of the side wall of the parallel flow chamber (3).

12. The microfluidic co-flow fusion device according to claim 11, characterized in that: The second inlet pipe (2) intersects perpendicularly or obliquely with the side wall of the parallel flow chamber (3).

13. The microfluidic co-flow fusion device according to claim 12, characterized in that: The second inlet pipe (2) intersects the side wall of the parallel flow chamber (3) at an angle of 5~55°.

14. The microfluidic co-flow fusion device according to any one of claims 1-13, characterized in that: The axis of the first inlet pipe (1) is perpendicular to the axis of the second inlet pipe (2) in space.

15. The microfluidic co-flow fusion device according to any one of claims 1-13, characterized in that: The fusion channel (4) is a tapered pipe that is wide at the inlet and narrow at the outlet.

16. The microfluidic co-flow fusion device according to claim 15, characterized in that: The inlet diameter of the fusion channel (4) is not lower than the outer diameter of the first liquid inlet chamber (302), and the outlet diameter of the fusion channel (4) is 0.1 to 0.8 times its inlet diameter.

17. The microfluidic co-flow fusion device according to claim 16, characterized in that: The diameter of the outlet of the fusion channel (4) is 0.3 to 0.5 times that of its inlet diameter.

18. The microfluidic co-flow fusion device according to any one of claims 1-13, characterized in that: The microfluidic co-flow fusion device also includes a bubble input pipe (5), which is located on the side wall of the fusion channel (4) near the outlet of the fusion channel (4) and is connected to the interior of the fusion channel (4).

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