Medical nanoparticle size fractionation purification apparatus

Abstract

The utility model discloses a medical nano particle size grading purification equipment, including purification bucket, the bottom fixedly connected with drive motor of purification bucket, the top fixedly connected with output shaft of drive motor, the top mounting of purification bucket has the apron, through the filter membrane and the inner wall of centrifugal barrel adhesion, rotates the lead screw, and the lead screw drives the pressing plate to remove, until the pressing plate will filter membrane fix in the inside of centrifugal barrel, at this moment, pour the nano particle suspension into the inside of centrifugal barrel, open drive motor, and drive motor drives output shaft rotation, and output shaft rotation drives fixed frame rotation, and then drive centrifugal barrel self -circulation, under the action of centrifugal force, cooperate filter membrane to nano particle and carry out grading, and in the process of centrifugal barrel rotation, the extrusion of knock rod is knocked off to the protruding piece, at this moment, the first spring in compression state drives knock rod reset, and knock rod knocks centrifugal barrel, so that filter membrane produces vibration, prevents and produces the jam.

Description

Technical Field

[0001] This utility model relates to the field of medical nanoparticle technology, specifically to a medical nanoparticle size classification and purification device. Background Technology

[0002] Medical nanoparticles are nanoscale particles used in the medical field, typically ranging in size from 1 to 100 nanometers. These nanoparticles have wide applications in drug delivery, diagnostics, imaging, and therapy. Due to their unique physical and chemical properties, medical nanoparticles can significantly improve drug bioavailability, targeting, and therapeutic efficacy.

[0003] In the traditional process of grading medical nanoparticles, sieving is mostly used to grade and sieve the nanoparticles. However, since the medical nanoparticles to be purified contain a large number of small nanoparticles, the nanoparticles may become clogged during purification, which will affect the normal progress of the purification work and reduce the efficiency of the work. Utility Model Content

[0004] The purpose of this invention is to provide a medical nanoparticle size classification and purification device to solve the problems mentioned in the background art.

[0005] To achieve the above objectives, this utility model provides the following technical solution: a medical nanoparticle size classification and purification device, comprising a purification tank, a drive motor fixedly connected to the bottom end of the purification tank, an output shaft fixedly connected to the top end of the drive motor, a fixed frame fixedly connected to the top end of the output shaft, a cover plate installed on the top end of the purification tank, and a purification mechanism provided inside the purification tank, the purification mechanism including a centrifuge tank.

[0006] As a further preferred embodiment of this technical solution, the inner wall of the centrifuge tank is provided with a filter membrane, and a fixed bracket is fixedly connected to the bottom of the inner side of the centrifuge tank. A lead screw is rotatably connected through the outer wall of the fixed bracket.

[0007] As a further preferred embodiment of this technical solution, the outer wall of the lead screw is threadedly connected to a pressing plate, the outer wall of the pressing plate is in contact with the outer wall of the filter membrane, and the outer wall of the centrifuge bucket is fixedly connected to a protrusion.

[0008] As a further preferred embodiment of this technical solution, a fixing rod is fixedly connected to the inner wall of the purification tank, a first spring is fixedly connected to the inner wall of the fixing rod, and a striking rod is fixedly connected to the end of the first spring away from the fixing rod.

[0009] As a further preferred embodiment of this technical solution, the fixed frame is provided with a limiting mechanism inside, and an insert block is fixedly connected to the top of the fixed frame.

[0010] As a further preferred embodiment of this technical solution, the bottom end of the centrifuge tank is provided with a slot, the inner wall of the slot is provided with a positioning hole, the outer wall of the insert is provided with a movable groove, and the inner wall of the movable groove is fixedly connected with a second spring.

[0011] As a further preferred embodiment of this technical solution, a positioning rod is fixedly connected to the end of the second spring away from the inner wall of the movable groove, and a movable ball is provided between the positioning rod and the movable groove.

[0012] This invention provides a medical nanoparticle size fractionation and purification device, which has the following beneficial effects:

[0013] (1) In this utility model, the filter membrane is attached to the inner wall of the centrifuge barrel. The screw is rotated and the screw drives the pressing plate to move until the pressing plate fixes the filter membrane inside the centrifuge barrel. At this time, the nanoparticle suspension is poured into the centrifuge barrel and the drive motor is turned on. The drive motor drives the output shaft to rotate and the output shaft drives the fixed frame to rotate, which in turn drives the centrifuge barrel to make a circular motion. Under the action of centrifugal force, the filter membrane is used to classify the nanoparticles. During the rotation of the centrifuge barrel, the protrusion falls off and squeezes the striking rod. At this time, the first spring in the compressed state drives the striking rod to reset. The striking rod strikes the centrifuge barrel, causing the filter membrane to vibrate and preventing blockage.

[0014] (2) By aligning the slot with the plug and inserting the plug into the slot, the centrifuge bucket can be quickly installed inside the fixed frame. When the fixed frame rotates, the centrifugal force drives the movable ball to move inside the movable slot, thereby driving the positioning rod to move outward and simultaneously driving the second spring to be in a stretched state. The positioning rod moves and inserts into the positioning hole, further maintaining the stability of the centrifuge bucket during operation. Attached Figure Description

[0015] Figure 1 This is a schematic diagram of the overall three-dimensional appearance structure of this utility model;

[0016] Figure 2 This is a schematic cross-sectional view of the overall structure of this utility model;

[0017] Figure 3 This is a schematic diagram of the purification mechanism of this utility model;

[0018] Figure 4 This is a schematic diagram of the limiting mechanism of this utility model.

[0019] In the diagram: 1. Purification tank; 2. Drive motor; 3. Cover plate; 4. Output shaft; 5. Fixed frame; 6. Purification mechanism; 61. Centrifuge tank; 62. Filter membrane; 63. Fixed bracket; 64. Lead screw; 65. Pressing plate; 66. Protrusion; 67. Fixed rod; 68. First spring; 69. Striking rod; 7. Limiting mechanism; 71. Insert block; 72. Slot; 73. Positioning hole; 74. Movable groove; 75. Second spring; 76. Positioning rod; 77. Movable ball. Detailed Implementation

[0020] The technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present invention.

[0021] This utility model provides a technical solution as follows: Figures 1 to 4 As shown in this embodiment, a medical nanoparticle size classification and purification device includes a purification tank 1. A drive motor 2 is fixedly connected to the bottom of the purification tank 1. An output shaft 4 is fixedly connected to the top of the drive motor 2. A fixed frame 5 is fixedly connected to the top of the output shaft 4. A cover plate 3 is installed on the top of the purification tank 1. A purification mechanism 6 is provided inside the purification tank 1. The purification mechanism 6 includes a centrifuge tank 61.

[0022] The centrifuge tank 61 has a filter membrane 62 on its inner wall, and a fixed bracket 63 is fixedly connected to the bottom of the centrifuge tank 61. A lead screw 64 is rotatably connected through the outer wall of the fixed bracket 63.

[0023] The filter membrane 62 can be used to classify nanoparticles according to their particle size.

[0024] The outer wall of the lead screw 64 is threaded with a pressing plate 65, the outer wall of the pressing plate 65 is in contact with the outer wall of the filter membrane 62, and the outer wall of the centrifuge barrel 61 is fixedly connected with a protrusion 66.

[0025] The filter membrane 62 can be fixed to the inner wall of the centrifuge tank 61 by pressing the plate 65.

[0026] The inner wall of the purification tank 1 is fixedly connected to a fixing rod 67, the inner wall of the fixing rod 67 is fixedly connected to a first spring 68, and the end of the first spring 68 away from the fixing rod 67 is fixedly connected to a striking rod 69.

[0027] The first spring 68 can drive the striking rod 69 to reset when it is not compressed, thereby causing the filter membrane 62 to vibrate.

[0028] The fixed frame 5 is equipped with a limit mechanism 7 inside, and the top of the fixed frame 5 is fixedly connected with an insert block 71.

[0029] The limiting mechanism 7 can limit the position of the centrifuge bucket 61.

[0030] The centrifuge tank 61 has a slot 72 at its bottom end, a positioning hole 73 on the inner wall of the slot 72, and a movable groove 74 on the outer wall of the insert block 71. A second spring 75 is fixedly connected to the inner wall of the movable groove 74.

[0031] The centrifuge tank 61 can be quickly installed via slot 72, which works in conjunction with the plug block 71.

[0032] The second spring 75 is fixedly connected to a positioning rod 76 at the end away from the inner wall of the movable groove 74, and a movable ball 77 is provided between the positioning rod 76 and the movable groove 74.

[0033] The movable ball 77, under the action of centrifugal force, can squeeze the positioning rod 76, thereby driving the positioning rod 76 to insert into the positioning hole 73.

[0034] This invention provides a medical nanoparticle size fractionation and purification device, the specific working principle of which is as follows:

[0035] In use, when purifying medical nanoparticles, align slot 72 with insert 71, insert 71 into slot 72, and then quickly install centrifuge tank 61 inside fixed frame 5. Place filter membrane 62 of appropriate particle size against the inner wall of centrifuge tank 61, rotate screw 64, which moves pressing plate 65 until pressing plate 65 fixes filter membrane 62 inside centrifuge tank 61. Then pour nanoparticle suspension into centrifuge tank 61, turn on drive motor 2, drive output shaft 4 to rotate, output shaft 4 rotates fixed frame 5, and centrifuge tank 61 moves in a circular motion under centrifugal force. Under the action of the filter membrane 62, the nanoparticles are classified. During the rotation of the centrifuge barrel 61, the protrusion 66 falls off and squeezes the striking rod 69. At this time, the first spring 68, which is in a compressed state, drives the striking rod 69 to reset. The striking rod 69 strikes the centrifuge barrel 61, causing the filter membrane 62 to vibrate and prevent clogging. When the fixed frame 5 rotates, the centrifugal force drives the movable ball 77 to move inside the movable groove 74, thereby driving the positioning rod 76 to move outward and simultaneously driving the second spring 75 to be in a stretched state. The positioning rod 76 moves and inserts into the positioning hole 73, further maintaining the stability of the centrifuge barrel 61 during operation.

[0036] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A medical nanoparticle size fractionation and purification device, comprising a purification tank (1), characterized in that: The bottom end of the purification tank (1) is fixedly connected to a drive motor (2), the top end of the drive motor (2) is fixedly connected to an output shaft (4), the top end of the output shaft (4) is fixedly connected to a fixed frame (5), the top end of the purification tank (1) is equipped with a cover plate (3), and the purification tank (1) is provided with a purification mechanism (6), which includes a centrifuge tank (61). The centrifuge barrel (61) is provided with a filter membrane (62) on its inner wall. A fixed bracket (63) is fixedly connected to the bottom of the centrifuge barrel (61). A screw rod (64) is rotatably connected through the outer wall of the fixed bracket (63). The outer wall of the lead screw (64) is threaded with a pressing plate (65), the outer wall of the pressing plate (65) is in contact with the outer wall of the filter membrane (62), and the outer wall of the centrifuge barrel (61) is fixedly connected with a protrusion (66). A fixing rod (67) is fixedly connected to the inner wall of the purification tank (1), and a first spring (68) is fixedly connected to the inner wall of the fixing rod (67). A striking rod (69) is fixedly connected to the end of the first spring (68) away from the fixing rod (67).

2. The medical nanoparticle size fractionation and purification device according to claim 1, characterized in that: The fixed frame (5) is provided with a limiting mechanism (7) inside, and the top of the fixed frame (5) is fixedly connected with a plug (71).

3. The medical nanoparticle size fractionation and purification device according to claim 2, characterized in that: The centrifuge barrel (61) has a slot (72) at the bottom end, and a positioning hole (73) is provided on the inner wall of the slot (72). The outer wall of the insert (71) has a movable groove (74), and a second spring (75) is fixedly connected to the inner wall of the movable groove (74).

4. The medical nanoparticle size fractionation and purification device according to claim 3, characterized in that: The second spring (75) is fixedly connected to a positioning rod (76) at one end away from the inner wall of the movable groove (74), and a movable ball (77) is provided between the positioning rod (76) and the movable groove (74).

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