A raw material medicine synthesis reactor sealing structure

Abstract

The application relates to the technical field of bulk drug synthesis, and particularly discloses a sealing structure of a bulk drug synthesis reactor, which comprises a reaction cylinder, a cover plate and a dosing cylinder, the bottom of the reaction cylinder is provided with a liquid outlet pipe, a switch valve is arranged on the liquid outlet pipe; the cover plate is connected to the top of the reaction cylinder through a locking assembly, a liquid inlet pipe is arranged on the cover plate in the vertical direction, the dosing cylinder is rotatably connected to the liquid inlet pipe in the horizontal direction, the outer diameter of the dosing cylinder is larger than the inner diameter of the liquid inlet pipe, a containing cavity is arranged in the dosing cylinder, liquid inlet holes for communicating the containing cavity are arranged on the peripheral wall of the dosing cylinder, and a rotating assembly for driving the dosing cylinder to rotate is arranged on the cover plate. The application has the effect of improving the problem that the cavity in the container is in communication with the external environment during the adding process of the additive, the internal environment of the reactor is changed, the reaction effect is affected, and the quality of the medicine is affected.

Description

Technical Field

[0001] This application relates to the field of active pharmaceutical ingredient (API) synthesis technology, and in particular to a sealing structure for an API synthesis reactor. Background Technology

[0002] Active pharmaceutical ingredients (APIs) refer to the raw materials used in the production of various preparations. They are the active ingredients in these preparations and are various powders, crystals, extracts, etc., prepared by chemical synthesis, plant extraction, or biotechnology for medicinal use. However, they are substances that patients cannot take directly. API synthesis reactors are required during API synthesis.

[0003] During the synthesis of active pharmaceutical ingredients (APIs), various additives need to be added to the reactor frequently. During the addition of additives, the internal cavity of the container is connected to the external environment, which can cause changes in the internal environment of the reactor, affecting the reaction effect and thus the quality of the drug. Utility Model Content

[0004] To address the issue that the connection between the container cavity and the external environment during the additive addition process can lead to changes in the internal environment of the reactor, affecting the reaction effect and thus the quality of the drug, this application provides a sealing structure for a drug substance synthesis reactor.

[0005] The sealing structure for a drug substance synthesis reactor provided in this application adopts the following technical solution:

[0006] A sealing structure for a pharmaceutical raw material synthesis reactor includes a reaction cylinder, a cover plate, and a dosing cylinder. The reaction cylinder has an outlet pipe at its bottom, and a switch valve is installed on the outlet pipe. The cover plate is connected to the top of the reaction cylinder via a locking assembly. An inlet pipe is vertically arranged on the cover plate. The dosing cylinder is rotatably connected to the inlet pipe and can rotate laterally within the inlet pipe. The outer diameter of the dosing cylinder is larger than the inner diameter of the inlet pipe. The dosing cylinder has a receiving cavity, and an inlet hole communicating with the receiving cavity is provided on the peripheral wall of the dosing cylinder. A rotating assembly for driving the dosing cylinder to rotate is provided on the cover plate.

[0007] By adopting the above technical solution, the cover plate is securely connected to the top of the reaction cylinder using a locking assembly, ensuring the overall sealing of the reactor and preventing leakage of the drug solution. During the synthesis reaction of the active pharmaceutical ingredient, the required liquid is added through the inlet pipe. A rotating assembly drives the dosing cylinder to rotate laterally within the inlet pipe, allowing the inlet holes on the cylinder's circumferential wall to connect or close with the inlet channel of the inlet pipe, thereby achieving precise control over the amount and timing of drug addition. After the reaction is complete, the valve on the outlet pipe is opened, allowing the reacted drug solution to be discharged from the outlet pipe at the bottom of the reaction cylinder. The dosing cylinder design keeps the reaction cylinder sealed from the outside environment during drug addition, mitigating the problem of changes in the internal environment of the reactor caused by communication between the container's interior and the external environment during additive addition, which could affect the reaction effect and thus the quality of the drug.

[0008] Optionally, the rotating assembly includes a rotating rod, a worm gear, and a worm. The rotating rod is coaxially connected to the dosing cylinder, the worm gear is coaxially connected to the rotating rod, and the worm is rotatably connected to the cover plate. The worm meshes with the worm gear.

[0009] By adopting the above technical solution, when the worm is rotated, the worm meshes with the worm wheel, which drives the worm wheel to rotate. The rotation of the worm wheel, in turn, causes the dosing cylinder to rotate laterally inside the liquid inlet pipe through the coaxially connected rotating rod. This achieves rotation control of the dosing cylinder, making it easier to adjust the position of the dosing cylinder to regulate the liquid inlet. The self-locking property of the worm wheel and worm gear transmission makes the rotation posture of the dosing cylinder more stable and enhances the sealing effect.

[0010] Optionally, the locking assembly includes a threaded sleeve and a connecting ring. The connecting ring is coaxially connected to the top peripheral wall of the reaction cylinder, and an external thread is provided on the peripheral wall of the connecting ring. The threaded sleeve is coaxially fitted onto the cover plate, and the threaded sleeve is rotatably connected to the cover plate around the axis of the cover plate. The threaded sleeve is threadedly connected to the external thread of the connecting ring.

[0011] By adopting the above technical solution, the threaded sleeve and the connecting ring are threaded together, which can firmly connect the cover plate to the top of the reaction cylinder, realize the sealed connection of the reactor, and this connection method is convenient to operate, easy to install and disassemble, and beneficial to equipment maintenance and repair.

[0012] Optionally, the cover plate has an insert plate at the bottom, and the connecting ring has a slot at the top, into which the insert plate is inserted; the connecting ring has a locking hole along its horizontal direction, into which a limiting rod is movably inserted; the insert plate has a limiting hole, into which the limiting rod is inserted; and the connecting ring has a moving component for driving the limiting rod to move.

[0013] By adopting the above technical solution, when the cover plate is placed on top of the reaction cylinder, the insert plate at the bottom of the cover plate is inserted into the slot at the top of the connecting ring. Then, the moving component on the connecting ring drives the limiting rod to move in the locking hole, so that the limiting rod is inserted into the limiting hole on the insert plate, thereby achieving further locking between the cover plate and the reaction cylinder, ensuring the stability and sealing of the connection between the two, and preventing leakage during the reaction process.

[0014] Optionally, the moving component includes a return spring, a sliding groove is provided on the inner wall of the locking hole, a sliding plate is provided on the limiting rod and slidably engaged in the sliding groove, one end of the return spring is connected to the sliding plate, the other end of the return spring is connected to the inner wall of the sliding groove, the return spring tends to move the sliding plate away from the insert plate, and a beveled surface is provided on the end of the limiting rod away from the insert plate, the beveled surface abutting against the bottom of the threaded sleeve.

[0015] By adopting the above technical solution, when the threaded sleeve rotates downward, its bottom will press against the beveled surface of the limiting rod, causing the limiting rod to overcome the elastic force of the return spring and insert into the limiting hole of the insert plate, thereby locking the insert plate and the connecting ring and enhancing the stability of the connection between the cover plate and the reaction cylinder. When the threaded sleeve rotates upward, the return spring can cause the sliding plate to drive the limiting rod away from the insert plate, making it easy to unlock and disassemble. Overall, it is easy to install and disassemble the cover plate and the reaction cylinder, ensuring the convenience of assembly and maintenance of the reactor sealing structure.

[0016] Optionally, the cover plate is equipped with a pressure sensor and a temperature sensor, the detection ends of which extend into the reaction vessel.

[0017] By adopting the above technical solution, pressure and temperature sensors can detect the pressure and temperature inside the reaction chamber in real time during the active pharmaceutical ingredient (API) synthesis reaction, which makes it easier for operators to monitor the reaction status, thereby ensuring the normal progress of the reaction and improving the quality and efficiency of API synthesis.

[0018] Optionally, the top of the inlet pipe is threaded with a screw cap.

[0019] By adopting the above technical solution, the threaded cap at the top of the inlet pipe can prevent foreign matter from entering the inlet pipe, while also making it easy to open for operations such as adding medicine.

[0020] In summary, this application includes at least one of the following beneficial technical effects:

[0021] 1. The dosing cylinder is rotatably connected to the inlet pipe, and the cover plate is equipped with a rotating component to drive its rotation. This allows for precise control of the amount and time of dosing according to actual reaction requirements. At the same time, it ensures that the reaction cylinder is not connected to the outside world during the dosing process, thereby improving the effect and quality of the raw material synthesis. It also addresses the problem that when the inner cavity of the container is connected to the external environment during the addition of additives, the internal environment of the reactor may change, affecting the reaction effect and thus the quality of the drug.

[0022] 2. The arrangement of the rotating rod, worm gear, and worm utilizes the self-locking property of the worm gear drive to ensure the stable and precise rotation of the dosing cartridge, thereby ensuring stable sealing performance;

[0023] 3. The matching arrangement of the return spring, sliding plate and limit rod with beveled surfaces allows the limit rod to be inserted into the limit hole on the insert plate when the threaded sleeve rotates downwards, without the need for an additional power source. The structure is simple and compact and easy to use. Attached Figure Description

[0024] To more clearly illustrate the technical solutions in the embodiments of this application, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Obviously, the accompanying drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0025] Figure 1 This is a schematic diagram of the overall structure of an embodiment of this application;

[0026] Figure 2 This is a cross-sectional structural diagram of an embodiment of this application;

[0027] Figure 3 yes Figure 2 A magnified view of part A in the diagram.

[0028] Reference numerals in the attached diagram: 1. Reaction cylinder; 11. Discharge pipe; 12. Switch valve; 13. Connecting ring; 131. Slot; 132. Locking hole; 133. Limiting rod; 134. Return spring; 135. Sliding groove; 136. Sliding plate; 2. Cover plate; 21. Pressure sensor; 22. Temperature sensor; 3. Dosing cylinder; 31. Receiving cavity; 32. Inlet hole; 33. Rotating rod; 34. Worm gear; 35. Worm; 36. Rotating handwheel; 4. Inlet pipe; 41. Cap; 5. Threaded sleeve; 6. Insert plate; 61. Limiting hole. Detailed Implementation

[0029] The following is in conjunction with the appendix Figure 1-3 This application will be described in further detail.

[0030] This application discloses a sealing structure for a drug substance synthesis reactor. (Refer to...) Figure 1-2 The sealing structure of the active pharmaceutical ingredient (API) synthesis reactor includes a reaction cylinder 1, a cover plate 2, and a dosing cylinder 3. Specifically, the reaction cylinder 1 is the container where the API synthesis reaction takes place. It is typically cylindrical in shape and made of corrosion-resistant metal materials, such as stainless steel. A liquid outlet pipe 11 is connected to the bottom of the reaction cylinder 1, and a switching valve 12 is installed on the liquid outlet pipe 11. The liquid outlet pipe 11 at the bottom of the reaction cylinder 1 is used to discharge the liquid after the reaction, and the switching valve 12 on the liquid outlet pipe 11 can control the flow of the liquid. The switching valve 12 can be a common valve type such as a ball valve or a butterfly valve.

[0031] The cover plate 2 is securely fitted to the top of the reaction cylinder 1 by a locking assembly. The cover plate 2 is a component used to seal the top of the reaction cylinder 1, and its material matches that of the reaction cylinder 1, usually stainless steel. A liquid inlet pipe 4 is vertically connected to the top of the cover plate 2, and a screw cap 41 is threaded to the top of the liquid inlet pipe 4. The bottom of the liquid inlet pipe 4 communicates with the inner cavity of the reaction cylinder 1. A cylindrical rotating cavity is provided in the middle of the liquid inlet pipe 4. The dosing cartridge 3 is rotatably connected to the rotating cavity of the liquid inlet pipe 4, and the outer peripheral wall of the dosing cartridge 3 is in contact with the inner wall of the rotating cavity. The outer diameter of the dosing cartridge 3 is larger than the inner diameter of the liquid inlet pipe 4. The dosing cartridge 3 is provided with a receiving cavity 31, and a liquid inlet hole 32 communicating with the receiving cavity 31 is provided on the peripheral wall of the dosing cartridge 3. A rotating assembly for driving the dosing cartridge 3 to rotate is provided on the cover plate 2.

[0032] During use, the locking assembly securely seals the cover plate 2 to the top of the reaction cylinder 1, achieving a complete seal of the reaction cylinder 1. When various additives need to be added, the screw cap 41 is unscrewed, and the dosing cylinder 3 is rotated by the rotating assembly so that the liquid inlet 32 ​​faces upward and connects with the liquid inlet pipe 4. The additives added through the liquid inlet pipe 4 enter the receiving cavity 31 of the dosing cylinder 3. Then, the rotating assembly drives the dosing cylinder 3 to rotate 180° so that the liquid inlet 32 ​​on the dosing cylinder 3 faces downward and connects with the reaction cylinder 1, allowing the additives to enter the reaction cylinder 1. At this time, the top peripheral wall of the dosing cylinder 3 blocks the liquid inlet pipe 4, isolating the reaction cylinder 1 from the outer wall, ensuring the sealing of the additives during the addition process. This improves the problem that the internal environment of the reactor changes due to the connection between the inner cavity of the container and the external environment during the addition of additives, which affects the reaction effect and thus the quality of the drug.

[0033] For example, the rotating assembly includes a rotating rod 33, a worm gear 34, and a worm 35. The rotating rod 33 is coaxially connected to the dosing cylinder 3, the worm gear 34 is coaxially connected to the rotating rod 33, and the worm 35 is rotatably connected to the cover plate 2. The worm 35 meshes with the worm gear 34, and a rotating handwheel 36 is connected to the end of the worm 35. By rotating the rotating handwheel 36, the worm 35 is driven to rotate, which in turn drives the worm gear 34 to rotate, thus synchronously driving the dosing cylinder 3 to rotate. The self-locking nature of the transmission between the worm gear 34 and the worm 35 makes the rotation adjustment of the dosing cylinder 3 more stable, thereby further ensuring the sealing during the additive addition process.

[0034] Specifically, the locking assembly includes a threaded sleeve 5 and a connecting ring 13. The connecting ring 13 is coaxially connected to the outer peripheral wall of the top of the reaction cylinder 1, and its upper surface is flush with the upper surface of the reaction cylinder 1. External threads are formed on the peripheral wall of the connecting ring 13. The threaded sleeve 5 is fitted onto the cover plate 2 and is rotatably connected to the cover plate 2 around its axis. The threaded sleeve 5 is threaded onto the external threads of the connecting ring 13. By rotating the threaded sleeve 5, the cover plate 2 is pressed tightly against the upper surface of the reaction cylinder 1, thus achieving a tight connection between the cover plate 2 and the reaction cylinder 1.

[0035] Furthermore, refer to Figure 3 To improve the firmness of the connection between the cover plate 2 and the reaction cylinder 1, multiple insert plates 6 are welded and fixed to the bottom of the cover plate 2. The top of the connecting ring 13 has a slot 131 corresponding to the insert plate 6, and the insert plate 6 is inserted into the corresponding slot 131. The connecting ring 13 has a locking hole 132 on the horizontal side, and a limiting rod 133 is movably inserted into the locking hole 132. The insert plate 6 has a limiting hole 61 on the horizontal side corresponding to the position of the limiting rod 133, and the limiting rod 133 extends into the limiting hole 61 on the insert plate 6. The connecting ring 13 is provided with a moving component for driving the limiting rod 133 to move.

[0036] When the threaded sleeve 5 is turned so that the insert plate 6 on the cover plate 2 is inserted into the slot 131 on the connecting ring 13, the moving component drives the limiting rod 133 to be inserted into the limiting hole 61 on the insert plate 6, which can prevent the insert plate 6 from coming out of the slot 131, thereby further improving the stability of the connection between the cover plate 2 and the reaction cylinder 1, and thus further improving the sealing performance.

[0037] Specifically, the moving component includes a return spring 134, a sliding groove 135 formed on the inner wall of the locking hole 132, and a sliding plate 136 slidably engaged within the sliding groove 135 on the limiting rod 133. One end of the return spring 134 is connected to the sliding plate 136, and the other end is connected to the inner wall of the sliding groove 135. The return spring 134 has a tendency to move the sliding plate 136 away from the insert plate 6. The end of the limiting rod 133 away from the insert plate 6 has a beveled surface, which abuts against the bottom of the threaded sleeve 5. As the threaded sleeve 5 is screwed downwards, its bottom presses against the beveled surface of the limiting rod 133, causing the limiting rod 133 to overcome the elastic force of the return spring 134 and insert into the limiting hole 61 of the insert plate 6, thereby locking the insert plate 6 and the connecting ring 13 and enhancing the stability of the connection between the cover plate 2 and the reaction cylinder 1. When the threaded sleeve 5 rotates upwards, the return spring 134 can cause the sliding plate 136 to move the limiting rod 133 away from the insert plate 6, making it easy to unlock and disassemble without the need for an additional power source, thus saving costs.

[0038] In addition, refer to Figure 1 The cover plate 2 is also equipped with a pressure sensor 21 and a temperature sensor 22, whose detection ends extend into the reaction vessel 1 to monitor the pressure and temperature inside the reaction vessel 1 in real time. The pressure sensor 21 and the temperature sensor 22 can be common electronic sensors, which are connected to an external display device via wires, allowing operators to monitor the situation inside the reaction vessel 1 at any time.

[0039] The implementation principle of the sealing structure of the active pharmaceutical ingredient synthesis reactor in this embodiment is as follows: When fixing the cover plate 2, the threaded sleeve 5 is rotated to connect with the external thread on the connecting ring 13, thereby connecting the cover plate 2 and the reaction cylinder 1. The threaded sleeve 5 moves to drive the cover plate 2 closer to the reaction cylinder 1. At this time, the insert plate 6 on the cover plate 2 is inserted into the insertion hole on the connecting ring 13. During the downward movement of the threaded sleeve 5, its bottom will press against the beveled surface of the limiting rod 133, causing the limiting rod 133 to overcome the elastic force of the return spring 134 and insert into the limiting hole 61 of the insert plate 6, thereby locking the insert plate 6 and the connecting ring 13, further improving the stability of the connection between the cover plate 2 and the reaction cylinder 1, and improving the sealing effect. When additives need to be added, unscrew the cap 41, turn the handwheel 36 to drive the worm gear 35 to rotate, which in turn drives the worm wheel 34 to rotate, thereby driving the dosing cylinder 3 to rotate until the liquid inlet 32 ​​on it is at the top and connected to the liquid inlet pipe 4. At this time, the peripheral wall at the bottom of the dosing cylinder 3 seals the bottom of the liquid inlet pipe 4, and the reaction cylinder 1 is not connected to the outside. After adding the additive through the top of the liquid inlet pipe 4, turn the worm gear 35 again to drive the dosing cylinder 3 to rotate until the liquid inlet 32 ​​on it is at the bottom and connected to the liquid inlet pipe 4, so that the additive in the receiving cavity 31 of the dosing cylinder 3 can be poured into the reaction cylinder 1. At this time, the peripheral wall at the bottom of the dosing cylinder 3 also seals the top of the liquid inlet pipe 4 to ensure the airtightness of the liquid addition process.

[0040] The above are all optional embodiments of this application and are not intended to limit the scope of protection of this application. Therefore, all equivalent changes made in accordance with the structure, shape and principle of this application should be covered within the scope of protection of this application.

Claims

1. A raw drug synthesis reactor seal structure, characterized by: The device includes a reaction cylinder, a cover plate, and a dosing cylinder. The bottom of the reaction cylinder is provided with a liquid outlet pipe, and a switch valve is provided on the liquid outlet pipe. The cover plate is connected to the top of the reaction cylinder by a locking assembly. A liquid inlet pipe is provided vertically on the cover plate. The dosing cylinder is connected to the liquid inlet pipe and can rotate horizontally within the liquid inlet pipe. The outer diameter of the dosing cylinder is larger than the inner diameter of the liquid inlet pipe. The dosing cylinder has a receiving cavity. A liquid inlet hole communicating with the receiving cavity is provided on the peripheral wall of the dosing cylinder. A rotating assembly for driving the dosing cylinder to rotate is provided on the cover plate.

2. A raw drug synthesis reactor sealing structure according to claim 1, characterized in that: The rotating assembly includes a rotating rod, a worm gear, and a worm. The rotating rod is coaxially connected to the dosing cylinder, the worm gear is coaxially connected to the rotating rod, and the worm is rotatably connected to the cover plate. The worm meshes with the worm gear.

3. The raw drug synthesis reactor sealing structure according to claim 1, characterized in that: The locking assembly includes a threaded sleeve and a connecting ring. The connecting ring is coaxially connected to the top peripheral wall of the reaction cylinder. The peripheral wall of the connecting ring is provided with an external thread. The threaded sleeve is coaxially fitted onto the cover plate. The threaded sleeve is rotatably connected to the cover plate around its axis. The threaded sleeve is threaded onto the external thread of the connecting ring.

4. The raw drug synthesis reactor sealing structure according to claim 3, characterized in that: The bottom of the cover plate is provided with an insert plate, and the top of the connecting ring is provided with a slot, in which the insert plate is inserted; the connecting ring is provided with a locking hole along the horizontal direction, in which a limiting rod is movably inserted; the insert plate is provided with a limiting hole, in which the limiting rod is inserted; the connecting ring is provided with a moving component for driving the limiting rod to move.

5. A raw drug synthesis reactor sealing structure according to claim 4, characterized in that: The moving component includes a return spring, a sliding groove is provided on the inner wall of the locking hole, a sliding plate is provided on the limiting rod and slidably engaged in the sliding groove, one end of the return spring is connected to the sliding plate and the other end of the return spring is connected to the inner wall of the sliding groove, the return spring tends to move the sliding plate away from the insert plate, and a beveled surface is provided on the end of the limiting rod away from the insert plate, the beveled surface abuts against the bottom of the threaded sleeve.

6. A raw drug synthesis reactor sealing structure according to claim 1, characterized in that: The cover plate is equipped with a pressure sensor and a temperature sensor, the detection ends of which extend into the reaction cylinder.

7. A raw drug synthesis reactor sealing structure according to claim 1, characterized in that: The top of the inlet pipe is threaded with a screw cap.

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