A modular microreaction device for the synthesis of heterocyclic compounds

Abstract

The utility model discloses a modularization trace reaction device for heterocyclic compound synthesis belongs to chemical reaction equipment technical field, including heating box, the left and right sides of heating box all are installed with the door plant, the inner wall on the front and back of heating box all is fixed with the track of placing and installs, the front and back of heating box respectively installs water inlet pipe and drain pipe. Through the screw thread connection's discharge pipe and connecting pipe, make multiple independent'horizontal material gathering box - trace heat exchange pipe'unit series connection, user can according to the path and time requirement of specific synthesis reaction, like increase or reduce the number of reaction unit like building blocks, thereby accurate control material's total residence time in the reaction system, when single reaction unit occurs the blockage or damage, can be individually disassembled and replaced, need not scrap the whole device, reduced maintenance cost and downtime.

Description

Technical Field

[0001] This utility model belongs to the technical field of chemical reaction equipment, specifically, it relates to a modular micro-reaction device for the synthesis of heterocyclic compounds. Background Technology

[0002] Heterocyclic compounds are widely found in natural products, drug molecules, pesticides, and functional materials, and their efficient and green synthesis has always been a research focus in the field of organic chemistry. Traditional heterocyclic synthesis is usually carried out in batch reactors (such as round-bottom flasks). This operation mode has problems such as low mass and heat transfer efficiency, imprecise control of reaction conditions, and significant scale-up effects. Especially when it involves strongly exothermic or temperature-sensitive reactions, it can easily lead to an increase in by-products, a decrease in yield, and even safety accidents.

[0003] To address the aforementioned problems, microchannel reaction technology has emerged. This technology utilizes microchannels with large specific surface areas as reaction sites, significantly improving mass and heat transfer efficiency, enabling precise control of reaction parameters, and providing excellent process safety, making it particularly suitable for hazardous chemical reactions and the synthesis of fine chemicals. However, existing microchannel reaction devices still have many limitations: Most existing devices have fixed reaction flow paths, with reaction volumes and path lengths determined after design and manufacturing. When faced with different reactions, especially complex reactions requiring different residence times or multiple steps in series, fixed flow paths cannot be flexibly adjusted. This results in a device often being only suitable for a limited number of reaction types, with poor versatility. In the multi-step synthesis of heterocyclic compounds, it is often necessary to precisely add another reagent or catalyst at a specific stage of the reaction. Most existing microreaction systems focus on single or pre-mixed material reactions and lack a reliable excipient addition mechanism that can be integrated into a continuous flow, can be started / stopped on demand, and is sealed. The usual solution is to use an additional "T" type mixer, but this increases the system dead volume and connection complexity, and makes it difficult to achieve precise addition at multiple points in sequence.

[0004] To address the aforementioned issues, this application proposes a modular micro-reaction apparatus for the synthesis of heterocyclic compounds. Utility Model Content

[0005] In view of the problems in the related technologies, this utility model proposes a modular micro-reaction device for the synthesis of heterocyclic compounds to overcome the above-mentioned technical problems existing in the existing related technologies.

[0006] To achieve the above objectives, the present invention adopts the following technical solution: A modular micro-reaction device for the synthesis of heterocyclic compounds includes a heating chamber with door panels installed on both the left and right sides of the heating chamber, placement rails fixedly installed on the inner walls of the front and rear sides of the heating chamber, and water inlet pipe and water outlet pipe installed on the front and rear sides of the heating chamber, respectively. The microchannel reaction mechanism includes multiple transverse material collection boxes. Multiple micro heat exchange tubes are installed between two transverse material collection boxes, and the micro heat exchange tubes are interconnected with the corresponding two transverse material collection boxes. The transverse material collection boxes are slidably placed on two placement tracks on the same horizontal line. The auxiliary material supply mechanism includes multiple feeding boxes, which are fixedly installed on one side of the heating box. A conduit is installed on one side of each feeding box. A connecting box is installed on one of the two horizontal feeding boxes on the same horizontal line, and the connecting box is connected to the corresponding conduit.

[0007] Preferably, the microchannel reaction mechanism further includes a discharge pipe and a connecting pipe. The discharge pipe is rotatably installed at the bottom of one of the two horizontal material collection boxes on the same horizontal line, and the connecting pipe is slidably connected to the top of the other horizontal material collection box on the same horizontal line. The discharge pipe is threadedly connected to the corresponding connecting pipe.

[0008] By connecting the discharge pipe and the connecting pipe with threads, two sets of micro heat exchange tubes on different horizontal lines are interconnected, allowing flow between the micro heat exchange tubes on different horizontal lines and facilitating disassembly and installation, thereby increasing or decreasing the flow reaction time.

[0009] Preferably, a discharge pipe is installed at the bottom of the heating box, and the discharge pipe is threadedly connected to the lowest discharge pipe among a plurality of discharge pipes.

[0010] The feed pipe design facilitates the discharge of heterocyclic compounds from the discharge pipe, and the threaded connection allows for easy disassembly of the discharge pipe, enabling modular operation.

[0011] Preferably, the auxiliary material supply mechanism includes multiple conversion boxes, each conversion box is connected to a corresponding conduit, and the conduit is equipped with a valve. A telescopic box is slidably connected to one side of the conversion box, and the telescopic box and the conversion box are interconnected. A tapered tube is installed on one side of the telescopic box, and a fixed tube is installed on one side of the connecting box. The tapered tube and the fixed tube are movably matched.

[0012] By extending and retracting the telescopic box, the conical tube can be moved into the fixed tube, and the telescopic box and the connecting box can be connected to each other. At the same time, the connecting box and the corresponding transverse material collection box can be connected to each other, so that the auxiliary materials in the telescopic box can be introduced into the transverse material collection box for reaction operation.

[0013] Preferably, a fixing rod is fixedly installed on the inner wall of the connecting box, a top rod is slidably connected to the fixing rod, a stopper ball is fixedly installed at one end of the top rod, the stopper ball is plugged and cooperates with the fixing tube, and a top spring is fixedly installed on one side of the fixing rod, one end of the top spring is fixedly connected to one side of the stopper ball.

[0014] The sliding connection between the push rod and the fixed rod allows the fixed rod to limit the push rod, enabling the push rod to slide left and right on the fixed rod. Under the pushing action of the push spring, the push rod can push the stopper ball to push and seal the fixed tube, preventing liquid leakage.

[0015] Preferably, a screw is rotatably connected to one side of the conversion box, and the screw is threadedly connected to the telescopic box.

[0016] The screw is threadedly connected to the telescopic box, and the telescopic box is slidably connected to the conversion box, so that the rotating screw can drive the telescopic box to move back and forth.

[0017] In summary, the technical effects and advantages of this utility model are as follows: Multiple independent "transverse aggregate box-micro heat exchange tube" units are connected in series through threaded discharge pipes and connecting pipes. Users can increase or decrease the number of reaction units like building blocks according to the specific synthesis reaction path and time requirements, thereby precisely controlling the total residence time of materials in the reaction system. When a single reaction unit is blocked or damaged, it can be disassembled and replaced individually without scrapping the entire device, reducing maintenance costs and downtime.

[0018] With a remotely controllable excipient supply mechanism, auxiliary reagents can be precisely and on demand injected into the reaction system at specific locations without interrupting the main reaction flow. For heterocyclic synthesis that requires the addition of catalysts, initiators, or a second reactant midway, this design avoids the trouble of stopping the reaction or transferring materials in traditional methods, realizing continuous flow multi-step synthesis. By controlling the valves and screws on each conduit, the timing and amount of excipient addition can be precisely controlled, making the process more controllable and easier to automate. Each feed box has an independent passage and is connected to the main line through a conical tube / fixed tube interface, reducing cross-contamination between different excipients.

[0019] The auxiliary material addition interface employs a linkage mechanism of "top spring-stop ball" sealing and "screw-conical tube" opening. In the non-operating state, the stop ball automatically seals and fixes the tube under the action of the top spring; when addition is needed, rotating the screw pushes the conical tube into place, opening the stop ball and thus opening the flow path. The mechanical seal ensures that the auxiliary material passage is completely isolated and sealed when the main reaction system is working, preventing leakage and misflow. It achieves a rapid and controllable switch from "completely sealed" to "completely connected". The entire process can be completed by a motor-driven screw, which is very suitable for automated control and eliminates the need for manual insertion and removal of pipes. Attached Figure Description

[0020] Figure 1 This is a schematic diagram of the overall structure of this utility model; Figure 2 This is a schematic diagram of the rear view structure of this utility model; Figure 3 This is a schematic diagram of the microchannel reaction mechanism of this utility model; Figure 4 This is a schematic diagram of the auxiliary material supply mechanism of this utility model.

[0021] In the picture: 1. Heating box; 2. Door panel; 3. Placement track; 4. Microchannel reaction mechanism; 41. Horizontal material collection box; 42. Micro heat exchange tube; 43. Discharge pipe; 44. Connecting pipe; 45. Feeding pipe; 5. Auxiliary material supply mechanism; 51. Feeding box; 52. Conversion box; 53. Conduit; 54. Valve; 55. Telescopic box; 56. Conical tube; 57. Screw; 58. Connecting box; 59. Fixing pipe; 510. Fixing rod; 511. Top rod; 512. Stopper ball; 513. Top spring; 6. Water inlet pipe; 7. Drain pipe. Detailed Implementation

[0022] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present utility model. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments.

[0023] Reference Figures 1-4 A modular micro-reaction device for the synthesis of heterocyclic compounds includes a heating box 1, door panels 2 installed on both the left and right sides of the heating box 1, placement rails 3 fixedly installed on the inner walls of the front and rear sides of the heating box 1, and water inlet pipes 6 and drain pipes 7 installed on the front and rear sides of the heating box 1, respectively. The microchannel reaction mechanism 4 includes multiple transverse material collection boxes 41. Multiple micro heat exchange tubes 42 are installed between two transverse material collection boxes 41, and the micro heat exchange tubes 42 are interconnected with the corresponding two transverse material collection boxes 41. The transverse material collection boxes 41 are slidably placed on two placement tracks 3 on the same horizontal line. The auxiliary material supply mechanism 5 includes multiple material supply boxes 51, which are fixedly installed on one side of the heating box 1. A conduit 53 is installed on one side of each material supply box 51. A connecting box 58 is installed on one of the two horizontal material collection boxes 41 on the same horizontal line. The connecting box 58 is connected and cooperates with the corresponding conduit 53.

[0024] Reference Figure 1 and Figure 4The microchannel reaction mechanism 4 also includes a discharge pipe 43 and a connecting pipe 44. The discharge pipe 43 is rotatably installed at the bottom of one of the two horizontal material collection boxes 41 on the same horizontal line. The connecting pipe 44 is slidably connected to the top of the other horizontal material collection box 41 on the same horizontal line. The discharge pipe 43 is threadedly connected to the corresponding connecting pipe 44. A feed pipe 45 is installed at the bottom of the heating box 1. The feed pipe 45 is threadedly connected to the lowermost discharge pipe 43 among the multiple discharge pipes 43. Through the threaded connection between the discharge pipe 43 and the connecting pipe 44, the two sets of micro heat exchange tubes 42 on different horizontal lines are interconnected, so that the micro heat exchange tubes 42 on different horizontal lines can flow and are easy to disassemble and install, thereby increasing or decreasing the flow reaction time. The setting of the feed pipe 45 makes it easy to discharge heterocyclic compounds on the discharge pipe 43, and the threaded connection makes it easy to disassemble the discharge pipe 43, thereby enabling modular operation.

[0025] Reference Figure 4 The auxiliary material supply mechanism 5 includes multiple conversion boxes 52, each of which is connected to a corresponding conduit 53. A valve 54 is provided on the conduit 53. A telescopic box 55 is slidably connected to one side of the conversion box 52. The telescopic box 55 and the conversion box 52 are interconnected. A tapered tube 56 is installed on one side of the telescopic box 55, and a fixed tube 59 is installed on one side of the connecting box 58. The tapered tube 56 and the fixed tube 59 are movably connected. By telescopically moving the telescopic box 55, the tapered tube 56 can be moved into the fixed tube 59, thus connecting the telescopic box 55 and the connecting box 58. At the same time, the connecting box 58 is interconnected with the corresponding transverse material collection box 41, so that the auxiliary material in the telescopic box 55 can be introduced into the transverse material collection box 41 for reaction operation.

[0026] Reference Figure 2A fixing rod 510 is fixedly installed on the inner wall of the connecting box 58. A top rod 511 is slidably connected to the fixing rod 510. A stopper ball 512 is fixedly installed at one end of the top rod 511. The stopper ball 512 is plugged into the fixing tube 59. A top spring 513 is fixedly installed on one side of the fixing rod 510. One end of the top spring 513 is fixedly connected to one side of the stopper ball 512. A screw 57 is rotatably connected to one side of the conversion box 52. The screw 57 is threadedly connected to the telescopic box 55. Through the sliding connection between the top rod 511 and the fixing rod 510, the fixing rod 510 can move the top rod 511. 11 is limited so that the top rod 511 slides left and right on the fixed rod 510, and under the pushing action of the top spring 513, it can push the plug ball 512 to push and seal the fixed tube 59 to prevent liquid leakage. Through the threaded connection between the screw 57 and the telescopic box 55, and the sliding connection between the telescopic box 55 and the conversion box 52, the rotating screw 57 can drive the telescopic box 55 to move back and forth, thereby driving the tapered tube 56 to move into the fixed tube 59, and pushing the plug ball 512 out of the fixed tube 59, so that the tapered tube 56 and the connecting box 58 are connected to each other.

[0027] Working principle: During operation, the reactants in the feed box 51 are introduced into the corresponding transverse aggregate box 41 through the conduit 53, allowing the reactants to be located in the micro heat exchange tube 42 and rapidly heated and reacted under the action of the heating water source in the heating box 1. When it is necessary to add ingredients, the valve 54 on the conduit 53 corresponding to the feed box 51 of different types of ingredients is opened, and the corresponding screw 57 is rotated. The screw 57 is threadedly connected to the telescopic box 55, which drives the telescopic box 55 to move, thereby moving the conical tube 56 into the fixed tube 59 and pushing the stopper ball 512 out of the fixed tube 59 position, so that the conical tube 56 and the connecting box 58 are interconnected, allowing the auxiliary materials in the feed box 51 to pass through. The material is fed into the corresponding horizontal material box 41 through the connecting box 58, allowing for material addition according to different needs. The material in the feeding box 51 can also be added in different sequences as needed. The threaded connection between the discharge pipe 43 and the connecting pipe 44 enables interconnection between the two sets of micro-heat exchange tubes 42 on different horizontal lines, allowing for flow between the micro-heat exchange tubes 42 on different horizontal lines and facilitating disassembly and installation. This can increase or decrease the flow reaction time. The discharge pipe 45 facilitates the discharge of heterocyclic compounds from the discharge pipe 43, and the threaded connection allows for easy disassembly of the discharge pipe 43, enabling modular operation.

[0028] The above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A modular micro-reaction apparatus for the synthesis of heterocyclic compounds, comprising a heating chamber (1), characterized in that, Door panels (2) are installed on both the left and right sides of the heating box (1). Placement rails (3) are fixedly installed on the inner walls of the front and rear sides of the heating box (1). Water inlet pipe (6) and drain pipe (7) are installed on the front and rear sides of the heating box (1) respectively. The microchannel reaction mechanism (4) includes multiple transverse aggregate boxes (41), and multiple micro heat exchange tubes (42) are installed between two transverse aggregate boxes (41). The micro heat exchange tubes (42) are connected to the corresponding two transverse aggregate boxes (41). The transverse aggregate boxes (41) are slidably placed on two placement tracks (3) on the same horizontal line. The auxiliary material supply mechanism (5) includes multiple material supply boxes (51), which are fixedly installed on one side of the heating box (1). A conduit (53) is installed on one side of the material supply box (51). A connecting box (58) is installed on one of the two horizontal material collection boxes (41) on the same horizontal line. The connecting box (58) is connected and cooperates with the corresponding conduit (53).

2. The modular micro-reaction apparatus for the synthesis of heterocyclic compounds according to claim 1, characterized in that, The microchannel reaction mechanism (4) also includes a discharge pipe (43) and a connecting pipe (44). The discharge pipe (43) is rotatably installed at the bottom of one of the two horizontal material collection boxes (41) on the same horizontal line. The connecting pipe (44) is slidably connected to the top of one of the two horizontal material collection boxes (41) on the same horizontal line. The discharge pipe (43) is threadedly connected to the corresponding connecting pipe (44).

3. A modular micro-reaction apparatus for the synthesis of heterocyclic compounds according to claim 2, characterized in that, The bottom of the heating box (1) is equipped with a discharge pipe (45), which is threadedly connected to the lowest discharge pipe (43) among a plurality of discharge pipes (43).

4. The modular micro-reaction apparatus for the synthesis of heterocyclic compounds according to claim 1, characterized in that, The auxiliary material supply mechanism (5) includes multiple conversion boxes (52). The conversion boxes (52) are fixedly installed on the heating box (1). The conversion boxes (52) are connected to the corresponding conduits (53), and the conduits (53) are equipped with valves (54). A telescopic box (55) is slidably connected to one side of the conversion box (52). The telescopic box (55) and the conversion box (52) are interconnected. A tapered tube (56) is installed on one side of the telescopic box (55), and a fixed tube (59) is installed on one side of the connecting box (58). The tapered tube (56) and the fixed tube (59) are movably matched.

5. A modular micro-reaction apparatus for the synthesis of heterocyclic compounds according to claim 4, characterized in that, A fixing rod (510) is fixedly installed on the inner wall of the connecting box (58). A top rod (511) is slidably connected to the fixing rod (510). A stopper ball (512) is fixedly installed at one end of the top rod (511). The stopper ball (512) is plugged into the fixing tube (59). A top spring (513) is fixedly installed on one side of the fixing rod (510). One end of the top spring (513) is fixedly connected to one side of the stopper ball (512).

6. A modular micro-reaction apparatus for the synthesis of heterocyclic compounds according to claim 4, characterized in that, A screw (57) is rotatably connected to one side of the conversion box (52), and the screw (57) is threadedly connected to the telescopic box (55).

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