Freeze-drying protection device

Abstract

The utility model relates to the technical field of freeze drying, disclose a freeze -drying protection device, include: installation main part, installation main part inside is hollow structure, the upper and lower both ends of installation main part have first opening and second opening respectively, the diameter of first opening is less than the diameter of second opening, the bottle of penicillin, from second opening installs to the hollow structure of installation main part inside, the bacteria -resistant filter membrane is set up in the upper end surface of installation main part and sets up at first opening, be equipped with sealing element in installation main part, sealing element is adapted to the bottle of penicillin, makes installation main part inside form sealed state, the utility model discloses through the cooperation between the bacteria -resistant filter membrane, sealing element and the bottle of penicillin, make the device always keep the aseptic state in the whole process of loading sample, freeze drying and capping, avoid the pollution risk brought by the multiple transfer and open operation. The bottle of penicillin is installed in installation main part all the time, need not multiple transfer, simplify freeze -drying operation procedure, improved the quality and efficiency of laboratory preparation aseptic freeze -drying sample.

Description

Technical Field

[0001] This utility model relates to the field of freeze-drying technology, and specifically to a freeze-drying protection device. Background Technology

[0002] Freeze-drying technology is widely used in biomedicine, pharmaceutical formulation, and food science. Its advantages lie in its ability to maintain the integrity of the active ingredients, structure, and biological functions of samples to the greatest extent possible. Therefore, freeze-drying technology has found widespread application in biological products (such as vaccines, antibodies, and cell therapy products), pharmaceutical formulations (such as lyophilized powders for injection), and the food industry (such as freeze-dried fruits and freeze-dried coffee).

[0003] During the aseptic pilot-scale stage of product development, a small number of samples need to be obtained through aseptic freeze-drying to evaluate product performance. However, due to the small sample size, using large-scale production equipment in a clean area is energy-intensive and costly; therefore, the operation can only be carried out under laboratory conditions. At this time, it is essential to strictly adhere to the aseptic procedures used in the complete product manufacturing process to ensure the sterility of the samples and the reliability of the experimental results.

[0004] However, during the freeze-drying process, samples must be filled into vials and partially capped in a laminar flow hood to maintain the necessary internal pressure and gas flow. The samples are then transferred to the freeze dryer for further processing. Although operators take precautions such as wearing sterile gloves and using sterile tools during sample transfer and freeze-drying to provide some sterility, several inconveniences remain in practice. In particular, the freeze-drying process requires ensuring water evaporation, making complete sealing impossible. Furthermore, the structure and operation requirements of the freeze dryer mean that samples are inevitably exposed to a relatively non-sterile environment during transfer and freeze-drying. Airborne microorganisms may then invade and contaminate the samples, making it impossible to rule out the potential influence of microorganisms when assessing sample stability and physicochemical properties.

[0005] In existing conventional laboratories, freeze-drying operations are time-consuming due to cumbersome procedures and equipment incompatibility. Furthermore, multiple transfers and operations increase human resource costs, further driving up R&D expenses.

[0006] In summary, existing routine laboratory freeze-drying procedures have several unresolved issues regarding aseptic performance, ease of operation, and efficiency. These problems not only affect the reliability of experimental results but also hinder the progress of research and development. Utility Model Content

[0007] This invention provides a freeze-drying protection device to solve the problems of complex operation procedures, high risk of contamination, and low preparation efficiency in the laboratory preparation of sterile freeze-dried samples.

[0008] This utility model provides a freeze-drying protection device, comprising: The mounting body has a hollow internal structure, and the upper and lower ends of the mounting body have a first opening and a second opening, respectively. The diameter of the first opening is smaller than the diameter of the second opening. A vial, wherein the vial is installed into the hollow structure of the mounting body through the second opening; An antibacterial filter membrane is disposed on the upper end face of the mounting body and at the first opening; The mounting body is equipped with a sealing element that is compatible with the vial, thereby creating a sealed state inside the mounting body.

[0009] This invention, through the cooperation of the antibacterial filter membrane, sealing element, and vial, ensures that the lyophilization protection device remains sterile throughout the entire process of sample loading, lyophilization, and capping, effectively eliminating the contamination risks associated with multiple transfers and opening operations in traditional methods. Furthermore, the vial is installed entirely within the hollow structure of the main unit, eliminating the need for multiple transfers or opening operations, thus simplifying the lyophilization process and improving the quality and efficiency of preparing sterile lyophilized samples in the laboratory.

[0010] In one optional embodiment, the vial includes a body, a neck, an opening, and a rubber stopper, wherein the diameter of the opening is larger than the diameter of the neck, and the rubber stopper is used to seal the opening. The sealing element includes a first sealing ring and a second sealing ring, both of which are fitted onto the body of the vial.

[0011] In one alternative embodiment, a fastener is further included, detachably connected to the mounting body, for securely fixing the antibacterial filter membrane between the fastener and the mounting body.

[0012] In one optional embodiment, the mounting body includes a first mounting portion and a second mounting portion, the sealing member is located on the inner wall surface of the first mounting portion, and the lower end of the second mounting portion is provided with a first connecting portion; the fixing member is provided with a second connecting portion that matches the first connecting portion, and the fixing member is detachably connected to the mounting body through the first connecting portion and the second connecting portion, and the fixing member is tightly fitted to the upper end surface of the mounting body; wherein, the height of the second mounting portion matches the inner cavity of the fixing member.

[0013] In one optional embodiment, the first connecting part is an external thread provided at the lower end of the second mounting part, and the second connecting part is an internal thread that matches the external thread. Through the cooperation of the internal thread and the external thread, the fastener is detachably connected to the mounting body and the fastener is tightly fitted to the upper end surface of the mounting body.

[0014] In one optional embodiment, the upper end face of the fastener is provided with a third opening, which corresponds to the first opening.

[0015] Optionally, the upper end of the mounting body is provided with a protruding ring, which is formed by the inward indentation of the upper end of the mounting body, and the inner diameter of the protruding ring is the same as the diameter of the upper end of the mounting body after the inward indentation. The protruding ring and the mounting body together enclose and form an accommodating space.

[0016] In an alternative embodiment, a ring is further included, the ring being installed within the receiving space, and the antibacterial filter membrane being disposed on the upper end face of the ring.

[0017] In one optional embodiment, the ring includes a ring body and a protrusion located on the outer periphery of the ring body. The outer diameter of the ring body matches the diameter of the first opening, and the outer diameter of the protrusion matches the inner diameter of the ring. The ring body extends from the first opening into the mounting body, the protrusion is located within the receiving space, and the lower end face of the protrusion abuts against the upper end face of the mounting body.

[0018] In one optional embodiment, the ring is provided with a first through hole that penetrates the ring, the first through hole being connected to the hollow structure of the mounting body and corresponding to the first opening. Attached Figure Description

[0019] To more clearly illustrate the specific embodiments of this utility model or the technical solutions in the prior art, the drawings used in the description of the specific embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of this utility model. For those skilled in the art, other drawings can be obtained from these drawings without creative effort.

[0020] Figure 1 This is a schematic diagram of the structure of a freeze-drying protection device according to an embodiment of the present utility model; Figure 2 This is a schematic diagram of the installation body in a freeze-drying protection device according to an embodiment of the present utility model; Figure 3This is another structural schematic diagram of the mounting body in a freeze-drying protection device according to an embodiment of the present utility model; Figure 4 This is a schematic diagram of the structure of a freeze-drying protection device according to an embodiment of the present invention, showing the installation body, vial, and antibacterial filter membrane working together. Figure 5 This is a schematic diagram of the structure of a fixing component in a freeze-drying protection device according to an embodiment of the present utility model; Figure 6 This is another structural schematic diagram of the fixing component in a freeze-drying protection device according to an embodiment of the present utility model; Figure 7 This is a schematic diagram of the structure of a freeze-drying protection device according to another embodiment of the present invention; Figure 8 for Figure 7 The front view of the freeze-drying protection device shown; Figure 9 This is a schematic diagram of the installation body in a freeze-drying protection device according to another embodiment of the present invention; Figure 10 This is a schematic diagram of the structure of the ring in a freeze-drying protection device according to an embodiment of the present invention.

[0021] Explanation of reference numerals in the attached figures: 100. Mounting body; 110. First opening; 120. Second opening; 130. First mounting part; 131. First sealing ring; 132. Second sealing ring; 140. Second mounting part; 141. First connecting part; 142. Protruding ring; 200. Vial; 210. Bottle body; 220. Bottle neck; 230. Bottle mouth; 240. Rubber stopper; 300. Antibacterial filter membrane; 400. Fixing component; 410. Second connecting part; 420. Third opening; 500. Circular ring; 510. Circular ring body; 520. Protrusion; 530. First through hole. Detailed Implementation

[0022] To make the objectives, technical solutions, and advantages of the embodiments of this utility model clearer, the technical solutions of the embodiments of this utility model will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this utility model, not all embodiments. Based on the embodiments of this utility model, all other embodiments obtained by those skilled in the art without creative effort are within the protection scope of this utility model.

[0023] The following is combined Figures 1 to 10 The following describes embodiments of the present invention.

[0024] According to embodiments of the present invention, such as Figure 1As shown, a freeze-drying protection device is provided, comprising: a mounting body 100, the mounting body 100 having a hollow internal structure, and the upper and lower ends of the mounting body 100 having a first opening 110 and a second opening 120 respectively, the diameter of the first opening 110 being smaller than the diameter of the second opening 120; a vial 200, the vial 200 being installed into the hollow structure of the mounting body 100 through the second opening 120; an antibacterial filter membrane 300, the antibacterial filter membrane 300 being disposed on the upper end face of the mounting body 100 and disposed at the first opening 110; and a sealing element provided inside the mounting body 100, the sealing element being adapted to the vial 200 to form a sealed state inside the mounting body 100.

[0025] In this embodiment, the mounting body 100 has a hollow cylindrical structure, and its inner diameter is configured to accommodate the vial 200. This hollow structure is used to accommodate and initially fix the vial 200 during testing. The upper and lower ends of the mounting body 100 are respectively provided with a first opening 110 and a second opening 120. The first opening 110 is located on the upper end face of the mounting body 100, and the second opening 120 is located on the lower end face of the mounting body 100. The diameter of the first opening 110 is smaller than the diameter of the second opening 120. This allows the vial 200 to be inserted through the larger diameter second opening 120, while the antibacterial filter membrane 300 can be fixed through the smaller diameter first opening 110, providing a basic mounting framework for complete aseptic operation.

[0026] An antibacterial filter membrane 300 is positioned at the first opening 110. This membrane, with its antibacterial properties, allows moisture to escape during freeze-drying while preventing external bacteria from entering the freeze-drying protection device, thus maintaining a sterile environment inside. The sealing element is compatible with the vial 200. When the vial 200 is installed inside the mounting body 100, the sealing element, along with the vial 200 and the antibacterial filter membrane 300, creates a closed space inside the mounting body 100. This ensures that the freeze-drying protection device remains sterile throughout the freeze-drying and capping process. The vial 200, serving as the sample container, is installed entirely within the hollow structure of the mounting body 100, eliminating the need for multiple transfers or opening operations and directly eliminating the contamination risks associated with traditional methods.

[0027] Furthermore, such as Figures 2 to 4 As shown, the vial 200 includes a body 210, a neck 220, a mouth 230, and a rubber stopper 240. The diameter of the mouth 230 is larger than the diameter of the neck 220, and the rubber stopper 240 is used to seal the mouth 230. The sealing element includes a first sealing ring 131 and a second sealing ring 132, both of which are fitted onto the body 210 of the vial 200.

[0028] Specifically, the vial 200 has a body 210 for carrying the sample, a neck 220 as a transitional connection to the body 210, and a neck 230 connected to the neck 220, with the neck 230 having a larger diameter than the neck 220. A rubber stopper 240 directly seals the neck 230 to seal the vial 200. The sealing element consists of a first sealing ring 131 and a second sealing ring 132, both disposed inside the mounting body 100 and spaced apart from top to bottom. The first sealing ring 131 and the second sealing ring 132 are fitted onto the body 210 of the vial 200, and the tight fit between the body 210 and the sealing rings fills the gap between the mounting body 100 and the vial 200, achieving a preliminary sealed and fixed state inside the mounting body 100.

[0029] When using the freeze-drying protector, sample preparation is completed under aseptic conditions. After transferring the sample to vial 200, the rubber stopper 240 is partially pressed in. The vial 200 is then placed inside the mounting body 100, ensuring that the first sealing ring 131 and the second sealing ring 132 are both fitted onto the vial body 210. This is further enhanced by the antibacterial filter membrane 300 at the top of the mounting body 100, ensuring safe ventilation between the space inside the mounting body 100 and the outside environment, while preventing microorganisms and particulate matter from penetrating into the mounting body 100, thus maintaining a sterile environment within the mounting body 100. The freeze-drying protector is then placed entirely into a freeze dryer for freeze-drying. After freeze-drying, the device is removed from the freeze dryer, and the device is pressed to completely press the rubber stopper 240 into the vial 200 to achieve an aseptic seal. Finally, the outer aluminum cap is closed to complete the final packaging of the vial 200.

[0030] This invention, through the cooperation of the antibacterial filter membrane 300, the sealing element, and the vial 200, ensures that the freeze-drying protection device remains sterile throughout the entire process of sample loading, freeze-drying, and capping, effectively eliminating the contamination risks caused by multiple transfers and opening operations in traditional methods. Furthermore, the vial 200 is installed entirely within the hollow structure of the mounting body 100, eliminating the need for multiple transfers or opening operations, thus simplifying the freeze-drying process and improving the quality and efficiency of preparing sterile freeze-dried samples in the laboratory. Simultaneously, this invention, through multifunctional integration, reduces the number of required equipment, avoids resource waste, improves the applicability of the device, and lowers the purchase and maintenance costs of the equipment.

[0031] Furthermore, the mounting body 100 can be flexibly made of sterile materials such as stainless steel and polytetrafluoroethylene, which are resistant to high temperature and chemical corrosion. It has the characteristics of repeated sterilization and reuse, and excellent durability. This not only extends the service life of the mounting body 100, but also reduces the frequency of consumable replacement, thereby improving production efficiency and product quality. While ensuring aseptic freeze-drying, it significantly reduces the manufacturing cost of the freeze-drying protection device.

[0032] like Figure 5 , Figure 6 As shown, in one embodiment, a fastener 400 is also included, which is detachably connected to the mounting body 100 and is used to fix the antibacterial filter membrane 300 between the fastener 400 and the mounting body 100.

[0033] In this embodiment, the antibacterial filter membrane 300 needs to withstand the airflow pressure from the moisture discharge during the freeze-drying process. The fixing member 400 firmly presses down on the edge of the antibacterial filter membrane 300, preventing it from shifting, deforming, or falling off, thus ensuring the continuous effectiveness of the antibacterial filtration function. The fixing member 400 is dimensionally compatible with the mounting body 100. While rotating and clamping the antibacterial filter membrane 300, it fills the tiny gaps between the antibacterial filter membrane 300 and the mounting body 100, preventing bacteria from seeping in through the gaps and further ensuring the sterility of the mounting body 100. The fixing member 400 is detachably connected to the mounting body 100, making the replacement of the antibacterial filter membrane 300 and the cleaning of the device more convenient, without damaging the mounting body 100 or other sealing structures. This ensures that the device is reusable and can be quickly restored to a sterile and sealed state after maintenance.

[0034] Furthermore, the mounting body 100 includes a first mounting portion 130 and a second mounting portion 140. The sealing element is located on the inner wall surface of the first mounting portion 130, and the lower end of the second mounting portion 140 is provided with a first connecting portion 141. The fixing member 400 is provided with a second connecting portion 410 that matches the first connecting portion 141. Through the first connecting portion 141 and the second connecting portion 410, the fixing member 400 is detachably connected to the mounting body 100, and the fixing member 400 is tightly fitted with the upper end surface of the mounting body 100. The height of the second mounting portion 140 matches the inner cavity of the fixing member 400. The first connecting portion 141 is an external thread provided at the lower end of the second mounting portion 140, and the second connecting portion 410 is an internal thread that matches the external thread. Through the cooperation of the internal thread and the external thread, the fixing member 400 is detachably connected to the mounting body 100, and the fixing member 400 is tightly fitted with the upper end surface of the mounting body 100.

[0035] Specifically, the mounting body 100 is composed of a first mounting part 130 and a second mounting part 140. The first mounting part 130 is located at the lower end of the mounting body 100, and its inner wall surface is provided with a sealing element for engaging with the vial 200. The tight fit between the sealing element and the vial 200 achieves initial sealing of the device's interior. The second mounting part 140 is located at the upper end of the mounting body 100, and its lower end is provided with a first connecting part 141, which is located on the outer periphery of the second mounting part 140. The fixing member 400 is provided with a second connecting part 410 that matches the first connecting part 141. The second connecting part 410 is located on the inner wall surface of the fixing member 400. Through the engagement of the first connecting part 141 and the second connecting part 410, the fixing member 400 is detachably connected to the mounting body 100.

[0036] The first connecting part 141 has an external thread located at the lower end of the second mounting part 140, and the second connecting part 410 has an internal thread that matches the external thread. The engagement of the internal and external threads allows the mounting body 100 and the fixing member 400 to be connected as a whole, enabling easy assembly and disassembly of the fixing member 400. This meets the requirements for sealing, fixing, replacing, and cleaning the antibacterial filter membrane 300. Furthermore, the connection is secure after tightening and will not loosen during freeze-drying. The fixing member 400 has an internal cavity, and the height of the second mounting part 140 matches the internal cavity of the fixing member 400. By installing the second mounting part 140 into the internal cavity of the fixing member 400, and with the pre-tightening force when the threads are tightened, a good airtight fit is formed, effectively filling the assembly gap between the fixing member 400 and the mounting body 100, further blocking the bacterial infiltration path and improving the overall anti-contamination performance of the structure.

[0037] In one embodiment, the upper end face of the fastener 400 is provided with a third opening 420, which corresponds to the first opening 110.

[0038] In this embodiment, the third opening 420 on the upper surface of the fixing member 400 corresponds to the first opening 110, forming a longitudinal channel that penetrates the fixing member 400, the antibacterial filter membrane 300, and the mounting body 100, providing a physical path for airflow. The fixing member 400, through height matching with the second mounting part 140, achieves a tight fit when the threads are tightened, clamping the antibacterial filter membrane 300 at its edges. The third opening 420 only provides a channel in the central area, ensuring the stability of the edge clamping is not affected, and preventing the antibacterial filter membrane 300 from shifting due to airflow impact. During freeze-drying, water vapor generated by the sublimation of water in the sample needs to be discharged from the device through the longitudinal channel; outside air enters in the opposite direction through this longitudinal channel and is filtered by the antibacterial filter membrane 300 to remove bacteria. The longitudinal channel balances the pressure inside and outside the device, preventing device deformation or vial 200 seal failure due to pressure differences.

[0039] like Figures 7 to 10 As shown, in one embodiment, which is the second specific implementation of this embodiment, the upper end of the mounting body 100 is provided with a protruding ring 142. The protruding ring 142 is formed by an inward indentation of the upper end face of the mounting body 100, and the inner diameter of the protruding ring 142 is consistent with the diameter of the upper end face of the mounting body 100 after it is inwardly indented. The protruding ring 142 and the mounting body 100 together enclose a receiving space. Further, it also includes a circular ring 500, which is installed in the receiving space, and the antibacterial filter membrane 300 is disposed on the upper end face of the circular ring 500.

[0040] In this embodiment, along the height direction of the mounting body 100, a portion of the upper end of the mounting body 100 is recessed inward, such that this portion of the upper end is recessed a certain distance into the mounting body 100, thereby forming a protruding ring 142 integrally formed with the mounting body 100 at the upper end. When the fastener 400 is connected to the mounting body 100, the protruding ring 142 can fit tightly against the lower end face of the fastener 400, filling the tiny gap between the fastener 400 and the mounting body 100, further enhancing the sealing effect of the device and reducing the possibility of bacteria seeping in from the edges. The inner diameter of the convex ring 142 is consistent with the diameter of the inwardly recessed upper surface of the mounting body 100, so that the convex ring 142 and the upper surface of the mounting body 100 together form a receiving space. The circular ring 500 is installed in the receiving space, and the antibacterial filter membrane 300 is placed on the upper surface of the circular ring 500. This avoids the antibacterial filter membrane 300 from being directly attached to the upper surface of the mounting body 100, and prevents the risk of friction or excessive tightness caused by direct contact when fixing the fastener 400 (when the material is steel), which could lead to damage to the antibacterial filter membrane 300, thus ensuring the aseptic seal inside the mounting body 100. Through the cooperation of the convex ring 142 and the circular ring 500, the installation range of the antibacterial filter membrane 300 can also be limited to a fixed area, preventing the edge of the antibacterial filter membrane 300 from shifting or wrinkling.

[0041] Furthermore, the ring 500 can be made of sterile materials that are resistant to high temperatures and chemical corrosion, such as halogenated butyl rubber. This material not only possesses the characteristics of being repeatedly sterilizable and reusable, but also exhibits excellent durability and low cost. In addition, the flexibility of halogenated butyl rubber effectively prevents damage to the antibacterial filter membrane 300 caused by rigid friction, while its excellent sealing performance further enhances the sealing effect inside the mounting body 100, ensuring the stability of the sterile environment.

[0042] In one embodiment, the ring 500 includes a ring body 510 and a protrusion 520 located on the outer periphery of the ring body 510. The outer diameter of the ring body 510 matches the diameter of the first opening 110, and the outer diameter of the protrusion 520 matches the inner diameter of the protruding ring 142. The ring body 510 extends from the first opening 110 into the mounting body 100, the protrusion 520 is located in the receiving space, and the lower end face of the protrusion 520 abuts against the upper end face of the mounting body 100.

[0043] In this embodiment, the ring 500 has an integrally formed ring body 510 and a protrusion 520. The protrusion 520 is located on the outer periphery of the ring body 510 and is disposed at the upper end of the ring body 510. The outer diameter of the ring body 510 matches the diameter of the first opening 110, and the outer diameter of the protrusion 520 matches the inner diameter of the protruding ring 142, so that the ring 500 can be fixed to the mounting body 100 and the protrusion 520 can be installed in the receiving space to achieve precise radial positioning of the ring 500 and prevent the ring 500 from moving radially. When the ring 500 is placed in the receiving space, the lower end face of the protrusion 520 abuts against the upper end face of the mounting body 100 to form an axial rigid limit, so that the ring 500 has no radial shaking or axial movement within the mounting body 100, achieving complete fixation of the ring 500 within the mounting body 100 and providing a reliable support reference for the antibacterial filter membrane 300.

[0044] In one embodiment, the ring 500 is provided with a first through hole 530 that penetrates the ring 500. The first through hole 530 is connected to the hollow structure of the mounting body 100 and corresponds to the first opening 110.

[0045] In this embodiment, a first through hole 530 is provided on the ring 500, forming a vertically continuous path. The upper end of the ring 500 is connected to the antibacterial filter membrane 300, and the lower end is directly connected to the hollow structure of the mounting body 100, thus using the first through hole 530 as an airflow channel between the vial 200 and the antibacterial filter membrane 300. The first through hole 530 only serves as an airflow channel and does not change the coverage area of ​​the antibacterial filter membrane 300. The airflow must pass through the antibacterial filter membrane 300 before it can flow, ensuring that the air entering the device is always sterile.

[0046] Aligning the first through-hole 530 with the first opening 110 allows the first through-hole 530, the first opening 110, and the third opening 420 to be aligned. During freeze-drying, water vapor generated by sample sublimation can quickly reach the antibacterial filter membrane 300 through the first through-hole 530 and then exit the device through the subsequent openings, preventing water vapor retention due to obstruction by the ring 500. When outside air enters the device in the opposite direction, it must be filtered by the antibacterial filter membrane 300 before entering the hollow structure of the mounting body 100 through the first through-hole 530 to balance the pressure inside and outside the device, preventing pressure differences from causing the vial 200 to fail to seal or the device to deform.

[0047] Although embodiments of the present invention have been described in conjunction with the accompanying drawings, those skilled in the art can make various modifications and variations without departing from the spirit and scope of the present invention, and such modifications and variations all fall within the scope defined by the appended claims.

Claims

1. A freeze-drying protection device, characterized in that, include: The mounting body (100) has a hollow structure inside. The upper and lower ends of the mounting body (100) have a first opening (110) and a second opening (120) respectively. The diameter of the first opening (110) is smaller than the diameter of the second opening (120). A vial (200), wherein the vial (200) is installed into the hollow structure of the mounting body (100) through the second opening (120); Antibacterial filter membrane (300), the antibacterial filter membrane (300) is disposed on the upper end face of the mounting body (100) and disposed at the first opening (110); The mounting body (100) is provided with a sealing element, which is adapted to the vial (200) to form a sealed state inside the mounting body (100).

2. The freeze-drying protection device according to claim 1, characterized in that, The vial (200) includes a body (210), a neck (220), a mouth (230), and a rubber stopper (240). The diameter of the mouth (230) is larger than the diameter of the neck (220), and the rubber stopper (240) is used to seal the mouth (230). The sealing element includes a first sealing ring (131) and a second sealing ring (132), both of which are fitted onto the body (210) of the vial (200).

3. The freeze-drying protection device according to claim 1, characterized in that, It also includes a fastener (400) detachably connected to the mounting body (100) for fixing the antibacterial filter membrane (300) between the fastener (400) and the mounting body (100).

4. The freeze-drying protection device according to claim 3, characterized in that, The mounting body (100) includes a first mounting part (130) and a second mounting part (140). The sealing element is located on the inner wall surface of the first mounting part (130), and the lower end of the second mounting part (140) is provided with a first connecting part (141). The fixing member (400) is provided with a second connecting part (410) that matches the first connecting part (141). The fixing member (400) is detachably connected to the mounting body (100) through the first connecting part (141) and the second connecting part (410), and the fixing member (400) is tightly fitted to the upper end surface of the mounting body (100). The height of the second mounting part (140) matches the inner cavity of the fixing member (400).

5. The freeze-drying protection device according to claim 4, characterized in that, The first connecting part (141) is an external thread provided at the lower end of the second mounting part (140), and the second connecting part (410) is an internal thread that matches the external thread. Through the cooperation of the internal thread and the external thread, the fixing member (400) is detachably connected to the mounting body (100), and the fixing member (400) is tightly fitted to the upper end surface of the mounting body (100).

6. The freeze-drying protection device according to claim 3, characterized in that, The upper end face of the fastener (400) is provided with a third opening (420), which corresponds to the first opening (110).

7. The freeze-drying protection device according to any one of claims 1-6, characterized in that, The upper end of the mounting body (100) is provided with a protruding ring (142). The protruding ring (142) is formed by the inward indentation of the upper end of the mounting body (100), and the inner diameter of the protruding ring (142) is the same as the diameter of the upper end of the mounting body (100) after it is inwardly indented. The protruding ring (142) and the mounting body (100) together enclose a receiving space.

8. The freeze-drying protection device according to claim 7, characterized in that, It also includes a ring (500) installed within the receiving space, and the antibacterial filter membrane (300) is disposed on the upper end face of the ring (500).

9. The freeze-drying protection device according to claim 8, characterized in that, The ring (500) includes a ring body (510) and a protrusion (520) located on the outer periphery of the ring body (510). The outer diameter of the ring body (510) matches the diameter of the first opening (110), and the outer diameter of the protrusion (520) matches the inner diameter of the protruding ring (142). The ring body (510) extends from the first opening (110) into the mounting body (100), the protrusion (520) is located in the receiving space, and the lower end face of the protrusion (520) abuts against the upper end face of the mounting body (100).

10. The freeze-drying protection device according to claim 9, characterized in that, The ring (500) is provided with a first through hole (530) that penetrates the ring (500). The first through hole (530) is connected to the hollow structure of the mounting body (100) and corresponds to the first opening (110).

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