A dissolution apparatus
By introducing automated dosing and stirring components into the dissolution apparatus, the problem of uneven sample dosing in existing dissolution apparatuses has been solved, achieving precise dosing and uniform mixing of samples in the dissolution vessel, and improving the accuracy of experimental results.
Patent Information
- Application Number
- CN202522431274.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2025-11-17
- Publication Date
- 2026-11-03
- Estimated Expiration
- 2035-11-17
AI Technical Summary
Existing dissolution apparatuses suffer from time differences and uneven sample loading during the sample loading process, which affects the accuracy of experimental results.
A dissolution apparatus was designed, comprising a support plate, side supports, a water bath, an upper drive stage, and a touch screen. It employs an automated dosing component and a stirring component to ensure that each dissolution vessel is dosed simultaneously or sequentially, and to achieve uniform mixing of the samples through the stirring component.
This method enables precise sample loading and uniform stirring within the dissolution vessel, improving the reliability and consistency of experimental results.
Smart Images
Figure CN224933984U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the field of dissolution apparatus technology, specifically to a dissolution apparatus. Background Technology
[0002] A dissolution analyzer is a commonly used analytical instrument used to measure the dissolution rate of drugs, chemicals, or other substances under specific conditions. Dissolution rate refers to the concentration of a solute in a solution, usually expressed as a percentage or the mass of solute per unit volume of solution. Dissolution testing is a crucial step in drug development, quality control, and manufacturing processes.
[0003] The working principle of a dissolution meter is to place a solid sample of the substance to be tested in the instrument's dissolution tank, and then observe and record the dissolution process of the dissolved substances by stirring and simulating in vivo environmental conditions, such as temperature. The instrument generally uses techniques such as ultraviolet-visible spectroscopy, liquid chromatography, and high-performance liquid chromatography to quantitatively analyze and measure the dissolved substances.
[0004] A dissolution analyzer is an important analytical instrument widely used in drug development, quality control, and manufacturing processes. Dissolution testing allows for the assessment of a drug's dissolution rate, release performance, and consistency, thus providing crucial reference information for the development and production of pharmaceutical formulations.
[0005] Existing dissolution apparatuses typically consist of a water bath heating structure, dissolution cups, and stirring components. In actual use, samples need to be added manually in sequence, which leads to differences in the time of sample addition to each dissolution cup. Furthermore, the amount of sample added may vary due to temporary sample addition, affecting the experimental results. Utility Model Content
[0006] The purpose of this invention is to provide a dissolution apparatus to solve the problems mentioned in the background art.
[0007] To achieve the above objectives, this utility model provides the following technical solution: a dissolution apparatus, comprising:
[0008] Two support plates, two side brackets, a water bath housing, an upper drive platform, and a touch screen;
[0009] The two support plates are arranged parallel to each other on the upper and lower sides. The two side brackets are respectively fixedly connected to the two ends between the two support plates. The water bath shell is hollow and open at the top. The water bath shell is supported on the lower support plate. The upper drive platform is located on the upper part of the upper support plate. The touch screen is installed on the upper drive platform.
[0010] Dissolution cups are evenly inserted into the upper support plate, and the lower side of the dissolution cups extends into the water bath shell. The dissolution cups are equipped with a dosing component and a stirring component.
[0011] Preferably, the lower surface of the water bath shell and the lower support plate are provided with drain outlets at corresponding positions, and the drain outlets are detachably connected with caps. An electric heating component is provided inside the water bath shell.
[0012] Preferably, a support platform is provided at the edge of the upper surface of the upper bearing plate, and the upper end of the support platform is fixedly connected to the lower surface of the upper drive platform.
[0013] Preferably, the upper surface of the dissolution cup is provided with a sealing cap, and the dosing assembly and the stirring assembly are mounted on the sealing cap.
[0014] Preferably, the dosing assembly includes a track plate mounted on a sealing cover, a material discharge groove on the track plate, a sample chamber slidably connected to the track plate, and an electric telescopic rod mounted on the track plate, the telescopic end of the electric telescopic rod being fixedly connected to the sample chamber.
[0015] Preferably, the stirring assembly includes a drive motor mounted on the lower surface of the upper drive platform and a stirring shaft connected to the output shaft of the drive motor. The stirring shaft passes through the sealing cover and extends into the dissolution cup. A stirring and mixing rod is connected to the bottom end of the stirring shaft.
[0016] Preferably, a temperature sensor is provided on the sealing cap, and the probe of the temperature sensor extends to the lower side of the dissolution cup.
[0017] Compared with the prior art, the beneficial effects of this utility model are:
[0018] The dissolution cups are installed individually and can be fitted with rubber rings to cushion them. Each dissolution cup is installed separately to avoid interference between them.
[0019] The dosing assembly allows for simultaneous dosing of each dissolution vessel, while also accommodating sequential dosing, effectively improving the accuracy of dosing.
[0020] The stirring assembly agitates the components in the dissolution vessel, ensuring that the sample is mixed evenly. Attached Figure Description
[0021] Figure 1 This is a schematic diagram of the structure of this utility model;
[0022] Figure 2 This is a schematic diagram of the structure of this utility model after removing the water bath shell;
[0023] Figure 3 This is a schematic diagram of the structure inside the dissolution cup of this utility model;
[0024] Figure 4 This is a schematic diagram of the structure of the sealing cap, dosing assembly, and stirring assembly of this utility model.
[0025] In the diagram: 1. Side support; 2. Support plate; 3. Drain outlet; 4. Water bath shell; 5. Dissolution cup; 6. Upper drive stage; 7. Support platform; 8. Touch screen; 9. Stirring shaft; 10. Stirring rod; 11. Sealing cover; 12. Temperature sensor; 13. Track plate; 14. Feed trough; 15. Electric telescopic rod; 16. Sample chamber. Detailed Implementation
[0026] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.
[0027] In the description of this utility model, it should be understood that the terms "upper", "lower", "front", "rear", "left", "right", "top", "bottom", "inner", "outer", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model.
[0028] Example 1:
[0029] Please see Figure 1-4 This utility model provides a technical solution: a dissolution apparatus, comprising: two support plates 2, two side supports 1, a water bath shell 4, an upper drive stage 6, and a touch screen 8;
[0030] Two support plates 2 are arranged parallel to each other on their upper and lower sides. Two side brackets 1 are fixedly connected to the two ends between the two support plates 2. The water bath shell 4 is hollow and open at the top, and is supported on the lower support plate 2. The upper drive platform 6 is located on the upper part of the upper support plate 2, and the touch screen 8 is mounted on the upper drive platform 6. Dissolution cups 5 are evenly inserted into the upper support plate 2, and the lower side of the dissolution cups 5 extends into the water bath shell 4. The dissolution cups 5 are equipped with a dosing component and a stirring component. Drainage outlets 3 are provided on the lower surface of the water bath shell 4 and at corresponding positions on the lower support plate 2. The drainage outlets 3 are detachably connected to a cap. An electric heating component is installed inside the water bath shell 4.
[0031] Analysis of the above content: The solvent is pre-stored in the dissolution vessel 5. The sample is first made into equal amounts of granules (the required amount of granules can also be set according to experimental needs). Each sample is placed on the corresponding dosing component. When in use, water is pre-filled into the water bath shell 4. The electric heating component in the water bath shell 4 is powered on to heat the water in the water bath shell 4. The heated water then heats the water in the dissolution vessel 5. The power of the electric heating component can be controlled to control the water temperature.
[0032] During the process, the sample is added to the corresponding dissolution vessel 5 based on the dosing component (the dosing can be done simultaneously or sequentially by electronic control, depending on the usage requirements). After the dosing, the sample is stirred based on the stirring component. The stirring is stopped after the set time is reached, and the dissolution rate of the sample in the dissolution vessel 5 is detected (the detection here is based on existing technology and will not be described in detail here).
[0033] Example 2:
[0034] Please see Figure 1-4 Based on Embodiment 1, this utility model provides a technical solution: a support platform 7 is provided at the edge of the upper surface of the upper bearing plate 2, and the upper end of the support platform 7 is fixedly connected to the lower surface of the upper drive platform 6.
[0035] Analysis of the above content: The support platform 7 serves to support and fix the upper drive platform 6.
[0036] Example 3:
[0037] Please see Figure 1-4 Based on Embodiment 1, this utility model provides a technical solution: a sealing cover 11 is provided on the upper surface of the dissolution cup 5, and the dosing component and the stirring component are installed on the sealing cover 11.
[0038] Analysis of the above content: The sealing cap 11 seals the upper opening of the dissolution cup 5, which serves to prevent dust and facilitates the installation of the dosing and stirring components.
[0039] Example 4:
[0040] Please see Figure 1-4 The present invention provides a technical solution based on Embodiment 3: the dosing assembly includes a track plate 13 installed on the sealing cover 11, a feeding groove 14 is provided on the track plate 13, a sample chamber 16 is slidably connected on the track plate 13, and an electric telescopic rod 15 is also installed on the track plate 13, the telescopic end of the electric telescopic rod 15 is fixedly connected to the sample chamber 16.
[0041] Analysis of the above content: The telescopic end of the electric telescopic rod 15 can drive the sample chamber 16 to move. The sample chamber 16 is a hollow cylinder with openings on the top and bottom. It can store sample particles. The sample particles are blocked by the track plate 13 and will not fall. After the sample chamber 16 moves, when the sample chamber 16 is aligned with the feeding trough 14, the sample particles in the sample chamber 16 pass through the feeding trough 14 and fall into the dissolution cup 5.
[0042] Example 5:
[0043] Please see Figure 1-4 The present invention provides a technical solution based on embodiment three or embodiment four: the stirring assembly includes a drive motor mounted on the lower surface of the upper drive platform 6 and a stirring shaft 9 connected to the output shaft of the drive motor. The stirring shaft 9 passes through the sealing cover 11 and extends into the dissolution cup 5. The bottom end of the stirring shaft 9 is connected to a stirring and mixing rod 10.
[0044] Analysis of the above content: The output shaft of the drive motor stirs the sample and solvent in the dissolution cup 5 based on the stirring shaft 9 and the stirring mixing rod 10.
[0045] Example 6:
[0046] Please see Figure 1-4 Based on Embodiment 3 or Embodiment 4, this utility model provides a technical solution: a temperature sensor 12 is provided on the sealing cover 11, and the probe of the temperature sensor 12 extends to the lower side of the dissolution cup 5.
[0047] Analysis of the above content: Temperature sensor 12 detects the temperature inside the dissolution cup 5. The temperature for the dissolution test is different for each sample. The heating power of the electric heating component is adjusted based on the temperature detection result of temperature sensor 12. This adjustment is based on PLC, which is integrated on touch screen 8.
[0048] Meanwhile, the PLC can control equipment such as drive motors and electric telescopic pole 15 motors (the control method is existing technology and will not be described in detail here).
[0049] The foregoing has shown and described the basic principles, main features, and advantages of this utility model. It is obvious to those skilled in the art that this utility model is not limited to the details of the exemplary embodiments described above, and that it can be implemented in other specific forms without departing from the spirit or basic characteristics of this utility model. Therefore, the embodiments should be considered exemplary and non-limiting in all respects. The scope of this utility model is defined by the appended claims rather than the foregoing description. Therefore, it is intended that all variations falling within the meaning and scope of equivalents of the claims be included within this utility model, and no reference numerals in the claims should be considered as limiting the scope of the claims.
[0050] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.
Claims
1. A dissolution apparatus, characterized in that, include: Two support plates (2), two side brackets (1), a water bath shell (4), an upper drive platform (6), and a touch screen (8); Among them, the two support plates (2) are arranged in parallel on the upper and lower sides, and the two side brackets (1) are respectively fixedly connected to the two ends between the two support plates (2). The water bath shell (4) is hollow and open at the top. The water bath shell (4) is supported on the lower support plate (2). The upper drive platform (6) is located on the upper part of the upper support plate (2). The touch screen (8) is installed on the upper drive platform (6). Dissolution cups (5) are evenly inserted into the upper support plate (2). The lower side of the dissolution cups (5) extends into the water bath shell (4). The dissolution cups (5) are equipped with a dosing component and a stirring component.
2. The dissolution apparatus according to claim 1, characterized in that: The water bath shell (4) has a drain outlet (3) at the corresponding position on the lower surface and the lower support plate (2). The drain outlet (3) is detachably connected to a cover. An electric heating component is installed inside the water bath shell (4).
3. The dissolution apparatus according to claim 1, characterized in that: A support platform (7) is provided at the edge of the upper surface of the upper bearing plate (2), and the upper end of the support platform (7) is fixedly connected to the lower surface of the upper drive platform (6).
4. The dissolution apparatus according to claim 1, characterized in that: The upper surface of the dissolution cup (5) is provided with a sealing cap (11), and the dosing assembly and stirring assembly are installed on the sealing cap (11).
5. A dissolution apparatus according to claim 4, characterized in that: The dosing assembly includes a track plate (13) installed on a sealing cover (11), a feeding trough (14) is provided on the track plate (13), a sample chamber (16) is slidably connected to the track plate (13), and an electric telescopic rod (15) is also installed on the track plate (13), with the telescopic end of the electric telescopic rod (15) fixedly connected to the sample chamber (16).
6. A dissolution apparatus according to claim 4 or 5, characterized in that: The stirring assembly includes a drive motor mounted on the lower surface of the upper drive platform (6) and a stirring shaft (9) connected to the output shaft of the drive motor. The stirring shaft (9) passes through the sealing cover (11) and extends into the dissolution cup (5). A stirring rod (10) is connected to the bottom end of the stirring shaft (9).
7. A dissolution apparatus according to claim 4 or 5, characterized in that: A temperature sensor (12) is provided on the sealing cap (11), and the probe of the temperature sensor (12) extends to the lower side inside the dissolution cup (5).