Method for determining ultrasound dose parameters, electronic device and computer storage medium

Abstract

The present disclosure provides a method for determining ultrasound dose parameters, comprising: determining the information on the actual sound absorption energy distribution in the focal area according to the target transducer; provided that the information on the actual sound absorption energy distribution in the focal area meets the predefined conditions, determining the ultrasound dose parameters based on the information on the actual sound absorption energy distribution in the focal area and the information on the target object. The method for determining ultrasound dose parameters offered in this disclosure corresponds to a preoperative assessment based on the information on the actual sound absorption energy distribution in the focal area and enables the precise determination of the ultrasound dose parameters.It does not rely on human experience and does not require real-time monitoring to check for coagulative necrosis in the target. This contributes to increased safety and efficacy of ultrasound dose delivery in HIFU (High-Intensity Focused Ultrasound) technology, reduces the operational complexity of HIFU technology, and shortens the learning curve for operating HIFU technology. The disclosure also provides an electronic device and a computer storage medium.

Description

Field of the invention

[0001] The present invention relates to the field of ultrasound technology and, in particular, to a method for determining ultrasound dose parameters, an electronic device and a computer storage medium. Background of the invention

[0002] Ultrasound treatment technology is receiving increasing attention from various aspects such as scientific research, medical device development, clinical application, and the formulation of health guidelines. With the rapid development of ultrasound treatment technology, more than 2,800 hospitals in China have already applied this technology. The US Food and Drug Administration (FDA) has approved the application of this technology to prostate cancer, breast cancer, bone cancer, uterine fibroids, Parkinson's disease, and idiopathic tremor. The technology has been exported to more than 30 countries and has already treated more than 3 million patients. Ultrasound treatment technology is now not only a new technology for the treatment of malignant or benign tumors, but is increasingly developing into a new field and industry for the treatment of numerous non-tumor-related diseases.

[0003] In HIFU (High-Intensity Focused Ultrasound) technology, effective preoperative ultrasound dose assessment and delivery is key to improving the safety and efficacy of focused ultrasound. However, ultrasound dose delivery during clinical focused ultrasound treatment is still primarily based on the physician's experience, making it difficult for new users to learn and master focused ultrasound treatment, especially when treating specific medical conditions. Description of the invention

[0004] The present disclosure addresses the above-mentioned deficiencies of the existing technology and provides a method for determining ultrasound dose parameters, an electronic device, and a computer storage medium.

[0005] In the first aspect, an embodiment of the present disclosure provides a method for determining ultrasound dose parameters, comprising: determining the information on the actual sound absorption energy distribution in the focal area according to the target transducer; Provided that the information on the actual sound absorption energy distribution in the focal area meets the predefined conditions, determination of the ultrasound dose parameters based on the information on the actual sound absorption energy distribution in the focal area and the information on the target object.

[0006] In some embodiments, determining the information on the actual sound absorption energy distribution in the focal area according to the target transducer comprises: Acquiring B-mode ultrasound images of the target object according to the target transducer; Determination of information on the actual sound absorption energy distribution in the focal area using the B-mode ultrasound image.

[0007] In some embodiments, the B-mode ultrasound image comprises a B-mode ultrasound image before the ultrasound treatment and a B-mode ultrasound image after the ultrasound treatment. Determining the information on the actual sound absorption energy distribution in the focal region from the B-mode ultrasound image includes: Calculating the shift between the B-mode ultrasound image before ultrasound treatment and the B-mode ultrasound image after ultrasound treatment using a predefined block matching algorithm; Determination of the actual sound absorption energy distribution information in the focal area based on the displacement and the previously determined relationship between the displacement and the sound absorption energy distribution information in the focal area.

[0008] In some embodiments, the determination of the ultrasound dose parameters based on the information on the actual sound absorption energy distribution in the focal area and the information on the target object includes: Determination of the information on the tissue sound properties of the target object based on the information on the actual sound absorption energy distribution in the focal area and the information on the target object; Determination of ultrasound dose parameters based on tissue acoustic properties information.

[0009] In some embodiments, the tissue sound property information includes the sound pressure distribution information, sound intensity, sound velocity, sound attenuation, sound impedance, sound field, and energy deposition information.

[0010] In some embodiments, after determining the information on the actual sound absorption energy distribution in the focal area according to the target transducer, the method further comprises: Determining the reference information on the sound absorption energy distribution in the focal area corresponding to the target transducer based on the previously determined correlation between the output power of the transducers and the reference information on the sound absorption energy distribution in the focal area and the output power of the target transducer; The fulfillment of the specified conditions by the information on the actual sound absorption energy distribution in the focal area includes: the difference between the information on the actual sound absorption energy distribution in the focal area and the reference information on the sound absorption energy distribution in the focal area is smaller than a specified threshold value.

[0011] In some embodiments, the method further comprises: If the information on the actual sound absorption energy distribution in the focal area does not meet the specified conditions, a target transducer is reselected from several transducers with different output powers until the information on the actual sound absorption energy distribution in the focal area according to the newly selected target transducer meets the specified conditions.

[0012] In some embodiments, the ultrasound dose parameters include irradiation time parameters, irradiation mode parameters, and irradiation position parameters.

[0013] In the second aspect, the present embodiment also provides an electronic device comprising: One or more processors; A storage medium on which one or more programs are stored; when executed by the processor(s), the processor(s) enable the previously described method for determining the ultrasound dose parameters to be carried out.

[0014] In the third aspect, the present embodiment also provides a computer storage medium having stored thereon a computer program, which program, when executed, enables the previously described method for determining the ultrasound dose parameters.

[0015] Due to the gentle characteristics of focused ultrasound, various clinical target foci can be subjected to pre-irradiation to determine the information on the acoustic absorption energy distribution in the focal area. By using HIFU to acquire the acoustic radiation capability, the obtained information on the acoustic absorption energy distribution in the focal area becomes very similar to the actual surgical situation. The method for determining ultrasound dose parameters provided in this disclosure corresponds to a preoperative assessment based on the information on the actual acoustic absorption energy distribution in the focal area, and precise determination of the ultrasound dose parameters can be achieved.

[0016] The method for determining ultrasound dose parameters provided in the present disclosure does not rely on human experience or require real-time monitoring to check whether coagulative necrosis is occurring in the target object. By determining the information on the actual sound absorption energy distribution in the focal area according to the target transducer, a quantitative evaluation of the energy effect in the focal area is possible. If the information on the actual sound absorption energy distribution in the focal area meets the specified conditions, the ultrasound dose parameters can be directly determined based on the information on the actual sound absorption energy distribution in the focal area and the information on the target object.This contributes to increasing the safety and effectiveness of ultrasound dose delivery in HIFU technology, reducing the operational complexity of HIFU technology, and reducing the learning time for operating HIFU technology. Short description of the drawings Fig. 1: Flowchart 1 of the method for determining the ultrasound dose parameters according to the disclosed embodiment. Fig. 2: Flowchart 2 of the method for determining the ultrasound dose parameters according to the disclosed embodiment. Fig. 3: Flowchart 3 of the method for determining the ultrasound dose parameters according to the disclosed embodiment. Fig. 4: Flowchart 4 of the method for determining the ultrasound dose parameters according to the disclosed embodiment. Fig. 5: Flowchart 5 of the method for determining the ultrasound dose parameters according to the disclosed embodiment. Fig. 6: Block diagram of the system for determining ultrasound dose parameters according to the disclosed embodiment. Fig. 7: Diagram for selecting the converter according to the disclosed embodiment. Fig. 8: Working diagram of the method for determining the ultrasound dose parameters according to the disclosed embodiment. Examples of implementation

[0017] Exemplary embodiments are described in more detail below with reference to the accompanying drawings. However, these exemplary embodiments may be embodied in various forms and should not be considered limited to the embodiments shown herein. Rather, these exemplary embodiments are provided to fully and comprehensively present the present disclosure and to provide those skilled in the art with a thorough understanding of the scope of the disclosure.

[0018] As used in this description, the term “and / or” includes any and all combinations of the relevant enumerated elements.

[0019] The terms used in this specification are for the purpose of describing specific embodiments only and are not intended to limit the present disclosure. As used in this specification, the singular "a" and "a," "an," and "this" include the plural, unless the context clearly indicates otherwise. It is also understood that when the terms "including" and / or "made of" are used in this specification, this indicates that the recited features, assemblies, steps, operations, elements, and / or components are present, but do not preclude the presence or addition of one or more additional features, assemblies, steps, operations, elements, components, and / or assemblies thereof.

[0020] The described embodiments may be illustrated using the ideal schematic representations in the disclosure with reference to plan views and / or sectional views. Therefore, the illustrated example illustrations may be modified depending on the manufacturing technique and / or tolerances. Thus, the embodiments are not limited to the embodiments shown in the drawings, but also include configuration modifications formed due to the manufacturing process. Therefore, the regions shown in the drawings have schematic characteristics, and the shape of the regions shown in the drawings illustrates the specific shape of the component regions as an example, but should not be considered limiting.

[0021] Unless otherwise specified, all terms used in this specification (including technical and scientific terms) have the meaning commonly understood by those skilled in the art. It is also understood that terms defined in common dictionaries should be interpreted to be consistent with the meaning used in the relevant art and in the context of this disclosure and should not be understood as idealized or exaggerated, unless explicitly stated in this specification.

[0022] Currently, clinical HIFU (high-intensity focused ultrasound) treatment typically relies on the experience of medical personnel to assess and deliver the ultrasound dose. This makes it difficult for new users to learn and master focused ultrasound treatment, especially when treating specific cases. Furthermore, if medical personnel fail to accurately assess and control the ultrasound dose, an overdose of ultrasound can lead to significant side effects for the patient and compromise the safety and efficacy of the treatment.

[0023] Another common method for evaluating and delivering ultrasound dose is to monitor the target in real time for the presence of coagulative necrosis. Once coagulative necrosis is detected, ultrasound delivery is stopped. Conversely, if no coagulative necrosis is detected, the ultrasound dose is increased. For example, B-ultrasound can be used to monitor for the presence of coagulative necrosis, where a change in grayscale in the target area (i.e., the appearance of an area of ​​coagulatively massive echoes in the image) is considered the criterion for the presence of coagulative necrosis in the tissue. During treatment, it is then determined that coagulative necrosis is not present if no grayscale change occurs in the target area. However, if coagulative necrosis occurs, it is not necessarily accompanied by the area of ​​coagulatively massive echoes.If coagulative necrosis is already present in the treatment area but no area of ​​coagulatively massive echoes is visible in the image, increasing the ultrasound dose may compromise the safety of HIFU treatment. In addition to B-ultrasound monitoring, magnetic resonance imaging (MRI) can also be used to monitor temperature and assess the formation of coagulative necrosis. MRI imaging takes about 3 seconds, while the formation of coagulative necrosis with HIFU takes about 0.5 to 5 seconds. Therefore, MRI cannot provide real-time monitoring, and the temperature values ​​or calculated thermal doses do not provide sufficient information about the occurrence of coagulative necrosis. Therefore, this method is not practical.

[0024] In summary, ultrasound dose assessment and delivery in clinical HIFU treatment still presents many challenges.

[0025] Against this background, the present embodiment proposes to determine the ultrasound dose based on the information on the sound absorption energy distribution in the focal area. Accordingly, as in Fig. 1, the present embodiment provides a method for determining ultrasound dose parameters, which may include the following steps: Step S1: Determination of the information on the actual sound absorption energy distribution in the focal area according to the target transducer. Step S2: Assuming that the information on the actual sound absorption energy distribution in the focal area meets the predefined conditions, determine the ultrasound dose parameters based on the information on the actual sound absorption energy distribution in the focal area and the information on the target object.

[0026] The transducer is the central component of ultrasound devices and converts electrical, mechanical, or acoustic energy from one form to another. It is also called an active sensor. The focal region is the target area where the ultrasound is focused on the biological tissue. The target object can be biological tissue or an organism. Once the ultrasound dose parameters have been determined, the actual ultrasound dose can be adjusted using these parameters.

[0027] Due to the gentle properties of focused ultrasound, various clinical target foci can be subjected to pre-irradiation to determine information on the acoustic absorption energy distribution in the focal region. By using HIFU to acquire acoustic radiation capability, the obtained information on the acoustic absorption energy distribution in the focal region becomes very similar to the actual surgical situation. The method for determining ultrasound dose parameters provided in the present embodiment corresponds to a preoperative assessment based on information on the actual acoustic absorption energy distribution in the focal region and enables the precise determination of ultrasound dose parameters.

[0028] The method for determining ultrasound dose parameters provided in the present disclosure does not rely on human experience or require real-time monitoring to check whether coagulative necrosis is occurring in the target object. By determining the information on the actual sound absorption energy distribution in the focal area according to the target transducer, a quantitative evaluation of the energy effect in the focal area is possible. If the information on the actual sound absorption energy distribution in the focal area meets the specified conditions, the ultrasound dose parameters can be directly determined based on the information on the actual sound absorption energy distribution in the focal area and the information on the target object.This contributes to increasing the safety and effectiveness of ultrasound dose delivery in HIFU technology, reducing the operational complexity of HIFU technology, and reducing the learning time for operating HIFU technology.

[0029] In some embodiments, as in Fig. 2, the determination of the information on the actual sound absorption energy distribution in the focal area according to the target transducer (step S1) includes the following steps: S11: Acquisition of B-mode ultrasound images of the target object according to the target transducer; S12: Determination of information on the actual sound absorption energy distribution in the focal area using the B-mode ultrasound image.

[0030] The lower part of the target transducer is placed in a degassed water area, and the target object is placed in the upper part of the target transducer. When the target transducer is operating, the target object is scanned with B-mode ultrasound (hereinafter referred to as B-ultrasound) to obtain a B-ultrasound image of the target object. Based on the B-ultrasound image of the target object, the information on the actual sound absorption energy distribution in the focal area can be determined. This can be achieved by using artificial intelligence algorithms such as machine learning to learn the relationship between the displacement and the information on the sound absorption energy distribution in the focal area in advance. Once the B-ultrasound image of the target object is obtained, the displacement between the ultrasound images before and after ultrasound treatment is calculated.Subsequently, based on this calculated displacement, the corresponding relationship is looked up to determine the information on the actual sound absorption energy distribution in the focal area of ​​the target object.

[0031] In some embodiments, the B-mode ultrasound image includes a B-mode ultrasound image before the ultrasound treatment and a B-mode ultrasound image after the ultrasound treatment, as in Fig. As shown in Figure 3, the determination of the information on the actual sound absorption energy distribution in the focal area from the B-mode ultrasound image (step S12) includes the following steps: Step S121: Calculating the shift between the B-mode ultrasound image before ultrasound treatment and the B-mode ultrasound image after ultrasound treatment using a predefined block matching algorithm; Step S122: Determine the actual sound absorption energy distribution information in the focal area based on the displacement and the previously determined relationship between the displacement and the sound absorption energy distribution information in the focal area.

[0032] Where, the predefined block matching algorithm can be a coarse-fine block matching algorithm, or any other block matching algorithm that can calculate displacements between images.

[0033] Current imaging technology cannot determine the information on the actual acoustic absorption energy distribution at the target focus. However, the method for determining ultrasound dose parameters described in this embodiment uses the predefined block matching algorithm to calculate the shift between the B-mode ultrasound images before and after ultrasound treatment and determine the information on the actual acoustic absorption energy distribution in the focal region based on the shift and the previously determined relationship between the shift and the information on the acoustic absorption energy distribution in the focal region. This contributes to improving the safety and efficacy of ultrasound dose delivery in HIFU technology.

[0034] In some embodiments, as in Fig. As shown in Figure 4, the determination of the ultrasound dose parameters based on the information on the actual sound absorption energy distribution in the focal area and the information on the target object (step S2) may include the following steps: S21: Determination of the information on the tissue sound properties of the target object based on the information on the actual sound absorption energy distribution in the focal area and the information on the target object; S22: Determination of ultrasound dose parameters based on the information on tissue acoustic properties.

[0035] In some embodiments, the tissue sound property information includes the distribution information of sound pressure, sound intensity, sound velocity, sound attenuation, sound impedance, sound field, and energy deposition information.

[0036] If the target object is a biological object, the target object information may include, for example, gender, body mass index (BMI), and B-ultrasound dose tolerance index.

[0037] By pre-determining the correlation between the transducer output power and the reference information on the sound absorption energy distribution in the focal area, individualized ultrasound dose plans can be created for different target objects. In some embodiments, as in Fig. 5, the method may accordingly comprise, after determining the information on the actual sound absorption energy distribution in the focal area according to the target transducer (step S1), the following step: in step S1', determining the reference information on the sound absorption energy distribution in the focal area corresponding to the target transducer based on the previously determined correlation between the output power of the transducer and the reference information on the sound absorption energy distribution in the focal area and the output power of the target transducer.

[0038] The fulfillment of the specified conditions by the information on the actual sound absorption energy distribution in the focal area (step S2) accordingly includes: the difference between the information on the actual sound absorption energy distribution in the focal area and the reference information on the sound absorption energy distribution in the focal area is smaller than a specified threshold value.

[0039] The current target transducer is selected from several transducers with different output powers based on the actual situation of the target object. For example, the selection can be made based on information about the target object as well as information about the shape and size of the target focus.

[0040] If the selected target transducer affects the target object and the information on the actual sound absorption energy distribution in the focal area determined thereby does not deviate significantly from the previously determined reference information on the sound absorption energy distribution in the focal area corresponding to the target transducer (i.e., the difference between the information on the actual sound absorption energy distribution in the focal area and the reference information on the sound absorption energy distribution in the focal area is smaller than a predefined threshold), it can be assumed that the currently selected target transducer is suitable for application to the target object. Based on this target transducer, a treatment plan can be drawn up, i.e.Based on the information on the actual sound absorption energy distribution in the focal area obtained using this transducer and the information on the target object, the ultrasound dose parameters can be determined.

[0041] In the present embodiments, the transducer supports a wide range of output powers. A target transducer is selected from a range of transducers with different output powers. By adjusting the transducer output power and irradiating biological tissues, information on different magnitudes and distributions of sound absorption energy can be obtained, i.e., a correlation between the transducer output power and the reference information on the sound absorption energy distribution in the focal region can be obtained. Furthermore, as already mentioned, due to the gentle properties of focused ultrasound, various clinical target foci can be subjected to pre-irradiation to determine the information on the sound absorption energy distribution in the focal region.Therefore, the method provided in the present embodiment for determining the ultrasound dose parameters corresponds to a preoperative evaluation based on the information on the actual sound absorption energy distribution in the focal area. Combined with the assessment of whether the information on the actual sound absorption energy distribution in the focal area meets the predefined conditions, the entire process resembles a simulation validation, resulting in a precise determination of the ultrasound adjustment parameters.

[0042] In some embodiments, the method may also comprise the following steps: If the information on the actual sound absorption energy distribution in the focal area does not satisfy the predetermined conditions, reselecting a target transducer from a plurality of transducers with different output powers until the information on the actual sound absorption energy distribution in the focal area according to the newly selected target transducer satisfies the predetermined conditions.

[0043] In some embodiments, the ultrasound dose parameters include irradiation time parameters, irradiation mode parameters, and irradiation position parameters. The irradiation mode can include point scan mode and line scan mode.

[0044] Fig. 6 shows the block diagram of the system for determining the ultrasound dose parameters according to the present embodiments. It can be seen that the system for determining the ultrasound dose parameters comprises a scanning module, an imaging module, a calculation module, an evaluation module, a storage module, a determination module, a display module, and a generation module. In addition to the Fig. In addition to the modules shown in Figure 6, the system for determining ultrasound dose parameters may also include an ultrasound excitation system for the transducer, a HIFU control system, a water treatment system, etc. The scanning module is configured to scan the target object and send the scanned information to the imaging module connected to it. The imaging module is configured to create images based on the information sent by the scanning module. The calculation module calculates the information on the actual sound absorption energy distribution in the focal area based on the B-ultrasound images generated by the imaging module. In particular, the calculation module uses a coarse-to-fine 2D block matching method to calculate the shift between the B-images before and after the ultrasound treatment.Subsequently, the information on the actual sound absorption energy distribution in the focal area is determined based on the calculated displacement and the previously determined correlation between the displacement and the information on the sound absorption energy distribution in the focal area. This correlation was previously determined using deep learning algorithms. The evaluation module can send the information on the actual sound absorption energy distribution in the focal area obtained from the calculation module to the display module for display. The evaluation module is also used to calculate the actual sound absorption energy distribution in the focal area based on the information on the actual sound absorption energy distribution in the focal area obtained from the calculation module and the information on the target object stored in the storage module (e.g., patient identification, patient record, etc.).) to determine ultrasound dose parameters and send them, along with information on the actual sound absorption energy distribution in the focal area, to the determination module for medical personnel to use as a reference. The determination module can also forward the ultrasound dose parameters to the generation module, which adjusts the actual irradiation time, irradiation mode, and irradiation position parameters according to the ultrasound dose parameters. In addition, the determination module can also be connected to the scanning module to send control commands to the scanning module. The transducer can include more than three parameter specifications (e.g., aperture diameter, curvature radius, output power, etc.).

[0045] Fig. Figure 7 shows the diagram for selecting the transducer according to the present embodiment. A correlation between the output power of the transducer and the reference information on the sound absorption energy distribution in the focal area is determined in advance. Based on the actual patient situation, a transducer is selected from several transducers with different output powers. The information on the actual sound absorption energy distribution in the focal area, i.e., the sound energy emitted by the transducer to the disease area, is determined.It is checked whether the sound energy delivered by the transducer to the disease area exhibits a certain degree of correspondence with the disease area, i.e., whether the difference between the information on the actual sound absorption energy distribution in the focal area and the reference information on the sound absorption energy distribution in the focal area determined based on the correlation is less than a predefined threshold. If this is the case, an appropriate treatment plan is determined according to the currently selected transducer (i.e., ultrasound dose parameters are determined based on the information on the actual sound absorption energy distribution in the focal area and the information on the target object).Otherwise, a transducer is again selected from several transducers with different output power until the difference between the actual sound absorption energy distribution information in the focal area corresponding to the newly selected target transducer and the reference sound absorption energy distribution information in the focal area is smaller than the predefined threshold.

[0046] As in Fig.As shown, in the method for determining the ultrasound dose parameters according to the present embodiment, after setting the treatment parameters according to the determined ultrasound dose parameters and adjusting the actual irradiation time, irradiation mode, and irradiation position parameters, the shift between the B-ultrasound images can also be further monitored during the operation to continuously compare the actual sound absorption energy information in the focal area with the reference sound absorption energy information in the focal area and continuously adjust the treatment plan to obtain a better ultrasound dose delivery plan.

[0047] Furthermore, this disclosure also provides an electronic device comprising: - one or more processors; - a memory module on which one or more programs are stored; - wherein, upon execution of the program(s) by the processor(s), they cause the processor(s) to carry out the method described above for determining the ultrasound dose parameters.

[0048] This disclosure also provides a computer storage medium having stored thereon a computer program, the program, when executed, carrying out the method described above for determining the ultrasound dose parameters.

[0049] Currently, the following difficulties exist in the field of HIFU ultrasound dose assessment and delivery: 1. The differences in the acoustic and thermal properties of human tissue, as well as blood flow rates, are significant between different patients. Existing theoretical simulations typically use fixed acoustic and thermal parameter values, but experimental studies show that tissue parameters in the target area change with the formation of coagulative necrosis tissue. In this context, Garnier etc. measured the relationship between the attenuation coefficient of different fabrics and temperature changes, which is closer to experimental results compared to using fixed attenuation coefficients. 2. The construction of simulation models. Most existing nonlinear ultrasound simulations are based on the KZK equation, the Westervelt equation, or the Burgers equation. Although these models are accurate in many practical cases, they are still limited to simulating directional sound beams and usually only consider one-way propagation in a homogeneous medium, which is not entirely accurate in some cases. 3. During HIFU clinical treatment, the ultrasound beam passes through multiple tissue layers, such as skin, fat, and muscle. The thickness of each layer is uneven, and the boundaries are irregular. Due to attenuation, the ultrasound field strength is reduced in the tissue layers within the sound channel. In the nonlinear case, the attenuation effect is particularly pronounced, resulting in a significant attenuation of the generated harmonic frequency during HIFU treatment.

[0050] To overcome this difficulty, the present embodiments provide a solution by determining in advance a correlation between the output power of the transducer and the reference information on the sound absorption energy distribution in the focal area.

[0051] Those skilled in the art will appreciate that all or some steps of the method described above or functional modules / units in the devices may be implemented as software, firmware, hardware, or a suitable combination thereof. In a hardware implementation, the division of functional modules / units in the above description may not necessarily correspond to the division of the physical components. For example, a physical component may have multiple functions, or a function or step may be performed jointly by multiple physical components. Some or all of the physical components may be implemented as software executed by a processor (such as a central processor, digital signal processor, or microprocessor), implemented as hardware, or implemented as integrated circuits, such as application-specific integrated circuits.This software may be stored on a computer-readable medium, which may include computer-storable media (or non-volatile media) and communications media (or volatile media). As those skilled in the art will appreciate, the term "computer storage medium" includes all types of volatile and non-volatile, removable and non-removable media used in any method and technique for storing the information (e.g., computer-readable instructions, data structures, program modules, or other data). Computer storage media includes, but is not limited to, RAM, ROM, EEPROM, flash memory or other storage technologies, CD-ROM, Digital Versatile Disc (DVD) or other optical discs, magnetic cartridges, magnetic tapes, hard disks or other magnetic storage devices, and any other medium that can be used to store the desired information and can be accessed by a computer.Furthermore, it is generally known to those skilled in the art that communication media typically contain computer-readable instructions, data structures, program modules, or other data in modulated data signals such as carrier waves or other transmission mechanisms and may include any information transmission medium.

[0052] In this description, embodiments have been disclosed, and although specific terms have been used, these serve only as general explanatory meanings and are not to be interpreted in a limiting sense. In some cases, it will be apparent to those skilled in the art that, unless expressly stated otherwise, the described features, characteristics, and / or elements combined with a particular embodiment may also be used individually or in combination with features, characteristics, and / or elements described in connection with other embodiments. Therefore, those skilled in the art will understand that changes in various forms and details may be made without departing from the scope of this disclosure as defined by the appended claims.

Claims

[1] A method for determining ultrasound dose parameters, characterized by is that it includes the following steps: Determination of information on the actual sound absorption energy distribution in the focal area according to the target transducer; Provided that the information on the actual sound absorption energy distribution in the focal area meets predefined conditions, determination of the ultrasound dose parameters based on the information on the actual sound absorption energy distribution in the focal area and the information on the target object. [2] The method according to claim 1, characterized by is that the determination of information on the actual sound absorption energy distribution in the focal area according to the target transducer includes: Acquiring B-mode ultrasound images of the target object according to the target transducer; Determination of information on the actual sound absorption energy distribution in the focal area using the B-mode ultrasound image. [3] The method according to claim 2, characterized by is that the B-mode ultrasound image comprises a B-mode ultrasound image before the ultrasound treatment and a B-mode ultrasound image after the ultrasound treatment, wherein the determination of the information on the actual sound absorption energy distribution in the focal area from the B-mode ultrasound image comprises: Calculating the shift between the B-mode ultrasound image before ultrasound treatment and the B-mode ultrasound image after ultrasound treatment using a pre-specified block matching algorithm; Determination of the actual sound absorption energy distribution information in the focal area based on the displacement and the previously determined relationship between the displacement and the sound absorption energy distribution information in the focal area. [4] The method according to claim 1, characterized by is that the determination of ultrasound dose parameters based on the information on the actual sound absorption energy distribution in the focal area as well as the information on the target object includes: Determination of the information on the tissue sound properties of the target object based on the information on the actual sound absorption energy distribution in the focal area and the information on the target object; Determination of ultrasound dose parameters based on tissue acoustic properties information. [5] The method according to claim 4, characterized byis that the tissue sound property information includes distribution information of sound pressure, sound intensity, sound velocity, sound attenuation, sound impedance, sound field and energy deposition information. [6] The method according to any one of claims 1 to 5, characterized by is that the method, after determining the information on the actual sound absorption energy distribution in the focal area according to the target transducer, further comprises: Determining the reference information on the sound absorption energy distribution in the focal area corresponding to the target transducer based on the previously determined correspondence between the output power of the transducer and the reference information on the sound absorption energy distribution in the focal area and the output power of the target transducer; The fulfillment of the specified conditions by the information on the actual sound absorption energy distribution in the focal area includes: the difference between the information on the actual sound absorption energy distribution in the focal area and the reference information on the sound absorption energy distribution in the focal area is smaller than a specified threshold value. [7] The method according to claim 6, characterized by is that the method further comprises: If the information on the actual sound absorption energy distribution in the focal area does not meet the specified conditions, reselect a target transducer from several transducers with different output powers until the information on the actual sound absorption energy distribution in the focal area according to the newly selected target transducer meets the specified conditions. [8] The method according to any one of claims 1 to 5, characterized by is that the ultrasound dose parameters include the irradiation time parameters, irradiation mode parameters and irradiation position parameters. [9] An electronic device comprising: One or more processors; A storage medium on which one or more programs are stored; When executed by the processor(s), the program(s) enable the processor(s) to carry out the method for determining the ultrasound dose parameters according to any one of claims 1-8. [10] A computer reading medium having stored thereon a computer program, said program, when executed, enabling the method for determining the ultrasound dose parameters according to any one of claims 1 to 8.

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