Dietary supplement to enhance the effects of botulinum toxin, based on zinc and phytase

Abstract

Dietary supplement comprising at least one zinc compound and phytase, to enhance the effect of botulinum toxin and / or prolong its duration of action.

Description

Technical field:

[0001] The invention relates to the composition and use of a food supplement, in particular suitable as an adjunct to botulinum toxin applications (e.g. for aesthetic or medical indications), which significantly improves the effect and / or duration of action of the botulinum toxin injection through a targeted combination of zinc and phytase. State of the art:

[0002] Various dietary supplements containing zinc or enzymes are known. It has been found that zinc, in particular, can increase the effectiveness of botulinum toxin as a cofactor. However, the absorption of zinc from food is inhibited by phytic acid. The addition of phytase breaks down phytic acid and significantly increases the bioavailability of zinc, resulting in an improved effect observed in users. Description of the invention:

[0003] The present invention provides a specific, synergistically acting composition of zinc and phytase, optionally supplemented by further nutritionally advantageous additives (e.g. magnesium, vitamins such as vitamin C / E, amino acids or other minerals).

[0004] The dietary supplement is available in solid or liquid form, such as capsules, tablets, powder, or solution. It contains at least: • A zinc compound, preferably from the group consisting of zinc citrate, zinc gluconate, zinc bisglycinate, zinc oxide or zinc sulfate; • A phytase preparation of microbial origin, preferably from Aspergillus niger or Aspergillus oryzae; • Optional excipients and, if applicable, other dietary supplements.

[0005] The recommended daily dose corresponds to a range that ensures the effectiveness of the botulinum toxin effect, but is not strictly limited to absolutely specific amounts. Advantages of the invention: • Extended duration of action and / or increased effectiveness of botulinum toxin applications, • Improvement of zinc bioavailability and associated metabolic pathways, • Flexible adjustment of the formula with regard to dosage and further additives to individual needs.

Claims

[1] Dietary supplement comprising at least a zinc compound and phytase, for enhancing the effect of botulinum toxin and / or prolonging its duration of action. [2] Food supplement according to claim 1, characterized by that the zinc compound is chosen from the group consisting of zinc citrate, zinc gluconate, zinc bisglycinate, zinc oxide or zinc sulfate. [3] Food supplement according to claim 1 or 2, characterized by that the phytase is a microbially produced phytase, preferably obtained from Aspergillus niger or Aspergillus oryzae. [4] Food supplement according to any of the preceding claims, further comprising at least one additional nutritionally active additive selected from the group consisting of vitamins, minerals, trace elements, amino acids, antioxidants or dietary fiber. [5] Food supplement according to any of the preceding claims, available in solid or liquid dosage form, in particular as a capsule, tablet, powder or solution. [6] Use of the food supplement according to any one of claims 1 to 5 for enhancing the effect or prolonging the duration of action of botulinum toxin application in humans. [7] Food supplement according to any of the preceding claims, wherein the proportions of the zinc compound and / or phytase contained are selected within a range such that the efficacy of the preparation is maintained when the dosage is changed. [8] Food supplements according to any of the preceding claims, characterized by that further food supplements can be added without leaving the protected area.