SEPARATOR

Description

[0001] The invention relates to a separator with a separator insert.

[0002] Separators, as defined in this document, are used to separate a free-flowing suspension as the starting material into phases of different densities using a centrifugal field. Steam sterilization of the separators is required in a wide variety of applications. A relatively "small" steam-sterilizable separator with a disc pack, introduced to the market by the applicant, is the "CSC 6" separator with an equivalent clarification area of ​​6000 m². However, in some situations, such as in laboratories, this machine is still relatively large. The known disc pack separators available on the market are driven by a spindle, which in turn is driven directly or via a gearbox by a motor. Furthermore, these known machines are made of stainless steel. For these reasons, filters are currently very frequently used in laboratories instead of centrifugal separators.With a separator featuring a plate pack and disposable plastic components (single-use technology – single-use pre-qualified plastic parts), steam sterilization (SIP – Sterilization In Place) would not be necessary. It could be particularly suitable for use in biotechnology.

[0003] From WO 2014 / 000829 A1, a separator for separating a free-flowing product into different phases is known, comprising a rotatable drum with a drum lower section and a drum upper section, and a means arranged in the drum for processing a suspension in a centrifugal field from solids or for separating a heavier solid-like phase from a lighter phase in a centrifugal field, wherein one, several, or all of the following elements are made of plastic or a plastic composite material: the drum lower section, the drum upper section, and the clarifying means. In this way, it is possible to design part of the drum, or preferably even the entire drum—preferably including the inlet and outlet systems or sections—for single use, which is particularly advantageous for processing pharmaceutical products such as fermentation broths or the like.This is of interest and advantage because, after processing a corresponding batch of product, the product-contacting parts of the drum do not need to be cleaned during the preferably continuous operation; instead, the entire drum can be replaced. This separator is therefore particularly advantageous from a hygienic perspective. To achieve physical separation between this disposable drum and the drive unit, a contactless coupling between the drive and the drum is advantageous.

[0004] A further development is shown in the generic patent DE 10 2017 128 027. Here, the bearing devices are designed as magnetic bearings, and one of the magnetic bearing devices is preferably also used as a drive device for rotating the drum, which is held in suspension during operation. This eliminates mechanical components for rotating and supporting the drum, which favors the design as a separator with a single-use separator insert, since replacing this separator insert is very easy. The present invention also utilizes these advantages. Another example is known from DE 102020121419.

[0005] Against this background, the object of the invention is to optimize the replacement of a separator insert in a separator in order to facilitate its subsequent disposal as simply as possible. The separator insert is specifically designed or usable as a disposable element, thus making the separation process more controllable.

[0006] The invention solves this problem by means of a separator having the features of claim 1.

[0007] The design of the separator is intended to reduce cross-contamination during product processing.

[0008] For this purpose, a separator insert is used as a pre-assembled, replaceable unit within a separator. At the same time, the replaceable separator insert should be disposed of in a simple and straightforward manner. In particular, separate disposal of the separator insert and any residual liquid it contains should be possible.

[0009] In one version, the separator insert can be designed for insertion into stator units on a separator frame. In this version, the separator insert can comprise both a rotatably mounted drum and a housing that remains stationary during separation operation, as a pre-assembled, interchangeable unit.

[0010] In a second variant, the separator insert can be designed as a rotor with a rotatably mounted drum, preferably with an integrated separating agent, in particular a separating disc assembly, for use in a separator housing. The inlet and outlet system, i.e., the entirety of all inlets and outlets, can preferably and advantageously be at least partially or completely integrated into the separator insert, thus ensuring a hermetically sealed inlet and outlet from the separator housing. Unlike the previous variant, in this variant the housing remains part of the separator when the separator insert is changed. A disadvantage compared to the first variant is the more complex seal between rotating and non-rotating parts. An example of such a seal and a corresponding axially arranged inlet and outlet system is known, for example, from EP 2 864 053 B1.For a bottom feed, so-called mechanical seals can be used, which allow for the replacement of the separator insert. Such a seal is known, for example, from WO 2020 / 120358 A1.

[0011] In both of the aforementioned variants, the separator insert exhibits at least the following: i. a rotor rotatable about an axis of rotation, comprising a drum and a drum wall. In a preferred embodiment, the drum wall can be closed in a central region.

[0012] In the context of the present invention, the middle region is preferably defined as the region between 20-80% of the axial extent of the drum. ii. at least two rotor units as sub-elements of the magnetic bearing devices at two axially spaced locations of the rotor with the drum, with which the rotor with the drum can be suspended, rotatably mounted and set in rotation within the housing during separation operation, wherein the separator has at least one linear drive for the linear movement of at least one of the two receptacles relative to the separator insert (II, III).

[0013] Decoupling the separator insert from the magnetic bearing assembly can require additional force. If the separator insert is sufficiently heavy, the linear drive assists with decoupling and thus facilitates insert replacement.

[0014] Furthermore, the separator may include other components, including, among others: iii. preferably a separating agent arranged in the drum,

[0015] A plate pack consisting of separating plates can be used as a separating agent. iv. at least one product inlet line and two product outlet lines leading from the separator insert;

[0016] Advantageously, a separate drainage line can be provided to further reduce cross-contamination. In the context of the present invention, this is preferably not part of the drainage system. The product-contacting areas of the separator insert are partially or completely made of plastic.

[0017] In its single-use configuration, the use of plastic for the separator insert is optimal, allowing for the subsequent disposal of the separator insert or at least the product-contacting areas. This is advantageous for processing a wide variety of products in pharmaceuticals, radiotracer analysis, and biotechnology, such as in the extraction of phytotoxic agents, where contamination should be kept to a minimum even when changing the separator insert.

[0018] A replacement procedure may include at least the following steps. a) Providing the separator with a first separator insert (II) mounted on the frame (I)

[0019] This first separator insert is replaced after use with a second, uncontaminated and otherwise preferably identical separator insert. However, it is also possible that the separator inserts and preferably the separating agents of the separator inserts vary depending on the separation task. b) Introducing a feedstock to be separated into the separator; c) Discharging a first and second product stream, separated from the product mixture, through the two separate product discharge lines from the separator during a separation operation of the separator;

[0020] The separation process is hereinafter also referred to simply as "process". During this process, the products are separated according to their density in the centrifugal field of the separator. d) Stopping the separation process and draining any residual liquid remaining in the drum;

[0021] When the separation process is halted or stopped, any residual liquid remaining in the drum is drained, preferably by gravity-driven emptying.

[0022] The drum can still move slightly when the separation process is stopped, but gravity predominates and dictates the direction of emptying.

[0023] If a separate drainage pipe is used, it is preferably located along a bottom surface of the separator insert to ensure that the insert is emptied as completely as possible.

[0024] If step d) is performed with a separator insert in which the housing and rotor are combined in a pre-assembled unit, the drainage can be arranged such that both the drum and the housing are emptied of residual liquid via the drainage outlet line. More than one drainage outlet line may also be provided for this purpose. e) Replacement of the emptied, contaminated separator insert from the separator frame with an unused separator insert.

[0025] The emptied, contaminated separator insert can then be disposed of without having to drain the remaining liquid. When processing particularly problematic products, such as hazardous substances of various hazard classes, immediate contamination-proof packaging of the separator insert is recommended. Draining residual liquid with the separator insert disassembled is impractical and may require increased safety standards.

[0026] In a particularly preferred embodiment of the invention, the processing of the starting product, e.g., a suspension, is carried out by a separator with a frame and a separator insert interchangeably arranged on the frame, wherein the separator insert is designed to separate a flowable suspension in a centrifugal field into at least two flowable phases of different densities and forms a pre-assembled, interchangeable unit for insertion into stator units on the frame of the separator and comprises at least the following: a housing that is stationary during operation and is designed in the manner of a container that is closed except for a plurality of openings, a rotor arranged inside the housing and rotatable about an axis of rotation with a drum which has one or more openings, preferably a separation agent arranged in the drum,at least two rotor units for magnetic bearing devices at two axially spaced locations of the rotor with the drum, with which the rotor with the drum can be suspended within the housing during operation, rotatably mounted and set in rotation, wherein furthermore spaced apart from one another, receptacles with stator units of the bearing devices are formed on the frame, between which the housing of the separator insert is held rotationally fixed so that the rotor remains rotatable, wherein the relative position of the receptacles with the stator units of the bearing devices is changeable such that the separator insert is replaceable, wherein the housing and the receptacles have corresponding positive locking means to hold the housing rotationally fixed to the receptacles.

[0027] "In operation" means during centrifugal processing, when the rotor is rotating.

[0028] It is therefore possible to create a separator that has a disposable module with disposable components (drum and housing), while at least the frame and parts of the bearing and drive mechanism can be reusable. By changing the position, the corresponding positive locking elements can be engaged and disengaged to change the separator insert.

[0029] The invention enables the production of a separator in which a disposable separator insert can be used, preferably designed such that all product-contacting components are made of plastic or other non-magnetic materials that can be disposed of after a single use. Cleaning after use is therefore unnecessary. The machine and its operation can thus become significantly cheaper. Magnets can be recycled if necessary.

[0030] It is simple and safe that the frame has spaced-apart mountings for the bearing devices, between which the separator insert can be inserted in a rotationally fixed manner.

[0031] It may also be provided that the separator insert can be attached to the frame in a form-fit and force-fit manner, preventing rotation.

[0032] In a particularly simple design, the receptacles and the housing can have corresponding pins and recesses as positive locking elements to hold the housing rotationally fixed to the receptacles. This is especially simple if the receptacles and pins extend axially. Furthermore, the position of the receptacles, particularly on the console, can be adjusted to allow for changing the separator insert. For this purpose, the relative distance between the receptacles can be adjustable, or one or both receptacles can be designed to be hinged, swiveling, rotatable, or sliding to allow the separator insert to be positioned between them.Preferably, according to one variant, the relative vertical position can be changed by adjusting the vertical relative distance of the receptacles with the stator units of the bearing devices in such a way that the separator insert is replaceable, so that the corresponding positive locking means can be brought into and out of engagement by adjusting it.

[0033] This makes changing the separator insert after processing a batch quick and easy.

[0034] In a particularly simple first variant, only one of the two mounts can be adjustable, especially height-adjustable, on the frame, especially on the console, while the other mount is fixed to the frame, especially on the console. Alternatively, it is possible for both mounts to be adjustable, especially height-adjustable, on the frame, especially on the console.

[0035] Further advantageous embodiments of the separator are the subject of the dependent claims.

[0036] As mentioned previously, the separator insert can have an additional drainage line for draining the residual liquid remaining in the drum in step d). This is specifically provided in addition to the separator insert's inlet and outlet system. This eliminates the need for additional bypasses and control devices, unlike when emptying via a bottom inlet.

[0037] Draining the residual liquid remaining in the drum in step d) can include collecting the residual liquid outside the separator insert in a collection container, preferably a drainage bag. This allows the residual liquid to be transferred from the preferably hermetic environment of the separator insert to the equally hermetic environment of a contamination-proof collection container immediately before replacement. The contents of the collection container can be determined by weighing the empty and full containers, enabling a very precise determination of the residual liquid by weight. For hazardous substances, such as phytotoxins or radionuclides, an exact determination of the residual quantity may be necessary due to various national regulations.

[0038] The remaining liquid in the drum can be drained via a product inlet line, as an alternative to a drainage line, by draining it in step d). If the product inlet line is part of the replaceable separator insert, it can be replaced automatically. If part of the product inlet line or part of the inlet system with product-contacting surfaces is part of the housing, this part can preferably be designed to be replaceable so that it can be disposed of together with the separator insert. However, this may entail additional disassembly steps.

[0039] The product feed line or a connected downstream line element, preferably a hose or pipe, can include a changeover valve between a residual liquid collection container and a feed product container, wherein the changeover valve is actuated during draining in step d). A control unit can manage both the operating sequence of the described process and the actuation of the changeover valve, as well as, if applicable, other components for operating the separator, e.g., a peristaltic pump.

[0040] In one embodiment of the present invention, the separator insert can be designed as an interchangeable rotatably mounted rotor with an integrated inlet and outlet system within the housing of the separator, wherein the introduction of the starting product in step b) and the draining of the residual liquid in step d) take place via the product inlet line of the inlet system, wherein, prior to the draining of the residual liquid in step d), an inlet element connected to the product inlet line is replaced by a drain element with the collection container.

[0041] The central closed-walled area of ​​the drum can advantageously extend over 20-80% of the axial extent of the drum.

[0042] Particularly in the first variant, where the separator insert comprises the housing and the rotor, it is advantageous if at least one product discharge line, especially the discharge line of a heavy product stream, is connected to a pump, such as a peristaltic pump, particularly a peristaltic squeeze pump, whereby the pump regulates the pressure in the product discharge line. This allows the pump to generate back pressure against a product discharge of the heavy phase within the separator insert, for example by reducing the flow volume.

[0043] The pump can be switched off during the draining process in step d) or operate at a reduced pressure compared to step c), allowing the residual liquid to drain away by gravity. Alternatively, the product drain line can also have a pressure-reducing control device, preferably a valve, and particularly preferably a shut-off valve, to ensure emptying via the drainage line. The residual liquid can also be pumped out via this drainage line using negative pressure, either alternatively or additionally.

[0044] Furthermore, it is advantageous in step d) to drain the residual liquid from both the drum and the housing. This applies particularly to the first variant in which the housing and drum are part of the separator insert.

[0045] The removal of the contaminated first separator insert in step e) for replacement with a new second separator insert can be advantageously carried out by changing the relative position of the mounts with the stator units of the bearing devices.

[0046] An advantageous and simple method for changing a first separator insert of a separator in step e) for a second separator insert can particularly preferably be carried out with the following steps: a) Providing the separator with a first separator insert mounted on the frame; b) Adjusting the relative position, in particular the relative distance, of the receptacles and releasing the positive locking between the frame and the separator insert, and removing the first separator insert from the receptacles; c) Providing the second separator insert (before, during, or after steps a) and b); d) Inserting the other second separator insert into one of the receptacles so that the corresponding positive locking means at one end of the housing and at one of the receptacles engage with each other; and e) Adjusting the relative position, in particular the relative distance, of the receptacles until the corresponding positive locking means at both ends of the separator insert housing and at the two receptacles engage with each other in a rotationally fixed manner.

[0047] The discharge of a first and second product stream, separated from the product mixture, through the two separate product discharge lines from the separator during separation operation can advantageously be carried out in such a way that there are no connections between the product inlet system and the product discharge system outside of the separator. This ensures a hermetic, contamination-free discharge of the product inlet and discharge streams.

[0048] Furthermore, the discharge of a first and second product stream, separated from the product mixture, through the two separate product discharge lines from the separator during separation operation can be carried out in such a way that there are no connections between the product discharge system and the drainage discharge system outside the separator insert. The drainage discharge system preferably comprises the aforementioned drainage discharge line, optionally an additional pipe or hose connected to the drainage discharge line outside the separator insert, and the aforementioned collection tank.

[0049] Furthermore, the draining of residual liquid from the separator when the separator's separation operation is stopped in step d) preferably takes place in such a way that there are no connections between the product inlet system and the drainage system outside the separator insert.

[0050] Thus, the product inlet and / or product outlet is also hermetically sealed from the drainage system, thereby preventing cross-contamination.

[0051] The drainage line comprises a nozzle with a product-contacting surface, which is integrally molded to the housing in a medium-tight manner, and a pipe or hose line, preferably hermetically connected to it, for conveying the residual liquid into the collection container. The nozzle protrudes outwards from the housing. Preferably, said nozzle protrudes beyond the adjacent outer wall of the housing.

[0052] The housing preferably has a product inlet with an inlet line as well as a first and a second product outlet, wherein the drainage outlet line is arranged as a separate line opposite the product inlet and product outlet.

[0053] The inlet pipe can have an inlet nozzle protruding into the interior of the housing. This creates a height difference between the inlet opening and the drainage outlet opening, so that it is not necessary to close the product inlet to drain the residual liquid.

[0054] The hose or pipe lines may have a sterile coupling at the end.

[0055] The product feed system can advantageously include a pump, preferably a centrifugal pump, which is preferably replaced after the stop in step d).

[0056] The product inlet system, the product outlet system and the drainage system may preferably comprise interchangeable systems, in particular hoses or pipes inserted onto or attached to the product inlet line, the product outlet lines and / or the drainage outlet lines.

[0057] Advantageously, the flow rate of the product inlet or a physical measurement equivalent to the flow rate can be determined to control the pump performance, especially by a measurement without contact with the medium.

[0058] For optimal measurement data acquisition, the pump and flow meter can be arranged in a riser pipe of the product feed system.

[0059] A discharge of a heavy phase of the product discharge system can include a pump, preferably a peristaltic pump, which remains as part of the separator after the stop in step d), while the pipe element connected to the pump is replaced.

[0060] The discharge of the heavy phase can include a flow meter and / or a pressure sensor for adjusting the pressure in the discharge of the heavy phase based on the speed of the pump, with at least the flow meter being arranged along a riser pipe.

[0061] In a derivative of the light phase, it is advantageous to arrange a container in which the light phase is temporarily stored.

[0062] In the discharge of the light phase, an optical sensor for quality control can preferably be arranged, preferably fluid-mechanically behind the container.

[0063] In the discharge of the light phase, a pump can also be arranged, preferably fluid-mechanically behind the container.

[0064] The pump output can be controlled by measuring the weight of the container, preferably using a load cell.

[0065] The volume of residual liquid drained in step d) can also be measured, among other reasons, for accounting purposes.

[0066] Advantageously, a protective gas, preferably nitrogen or a noble gas, can be introduced into the separator insert before or during steps b) and c), in particular through one or more connection nozzles arranged separately from the product inlets and outlets on the housing of the separator insert.

[0067] Furthermore, it is advantageous to extract air from the separator insert through the connection nozzle(s) before step b), e.g. to subsequently flood the separator insert with protective gas.

[0068] Finally, to accelerate and ensure the completeness of the emptying process, air can be introduced into the separator insert through the connection nozzle(s) during the emptying of the separator insert according to step c).

[0069] The following are further advantageous embodiments, which relate in particular to the first variant of the separator insert of a separator according to the invention.

[0070] Furthermore, it is particularly advantageous and simple from a design perspective if one or both mounts are slidably arranged on the frame, especially on the console.

[0071] It is further advantageous if, when inserting the separator insert into one or both of the receptacles, one or more axially extending hoses are guided through a respective through-opening of the respective receptacle on the separator insert.

[0072] It is preferred, because it is simple and practical, that the rotor units are arranged at the two axial ends of the drum, and that two corresponding stator units are formed on the separator frame. In this way, magnetic bearing devices are formed at both axial ends of the drum.

[0073] It is particularly advantageous that, according to the invention, the functionally required position of the stator units and the rotor units relative to each other is mechanically ensured. This applies especially to the precise axial and radial centering of the stator and rotor units, which are coaxially nested within each other.

[0074] The invention also provides a separator insert for separating a flowable suspension in a centrifugal field into at least two flowable phases of different densities, which forms a pre-assembled, interchangeable unit for insertion into stator units on the separator frame and comprises at least the following: a housing that remains stationary during operation and is designed in the manner of a container, which is closed except for one or more openings; a rotor arranged within the housing and rotatable about an axis of rotation, with a drum having one or more openings; a separating agent arranged in the drum; at least two rotor units for magnetic bearing devices at two axially spaced locations on the drum, with which the rotor with the drum can be suspended within the housing during operation, rotatably mounted, and set in rotation, wherein the housing has positive locking means.to hold the housing rotationally fixed to a support. This separator insert is particularly suitable for a separator as an interchangeable module, where the frame, especially its mounts, forms the support(s).

[0075] In an advantageous embodiment, at least one of the two magnetic bearing devices preferably also constitutes the rotary drive for the drum, and this drive is also suitable for driving the drum at freely adjustable speeds or in a freely selectable direction of rotation. It can preferably be provided that one or both magnetic bearing devices act radially and axially and, during operation, suspend the rotor at a distance from the container.

[0076] The rotor and stator units work together to form magnetic bearing devices. These allow the drum to be supported axially and radially and to be suspended.

[0077] In a further advantageous and structurally particularly simple variant, it is additionally provided that a further opening in the drum is designed as a free radial outlet for a second of the flowable phases from the drum into the housing, from which it can be drained. It can also be advantageously and simply provided that a collecting annular chamber of the housing is associated with the free outlet, which has a drain from the housing.

[0078] However, another advantageous variant, which is particularly easy to implement structurally, can additionally provide for a further opening in the drum to discharge the remaining flowable phases from the drum, designed as a peeling disc. It can then be advantageously provided that the peeling disc has a discharge pipe that is coaxial with the inlet pipe and extends coaxially from the drum and through the opening in the first axial boundary wall of the housing.

[0079] In order to control the separation process effectively, i.e., to be able to steer or regulate it, it may also be provided that a control valve is connected downstream of the first peeling disc and / or the second peeling disc on the flow side - i.e., possibly on the outflow side - which can be controlled by a control device.

[0080] It can be further preferably provided that a disc stack is arranged in the drum as a separating agent and that a peeling disc is arranged in the drum below the distributor and below the disc stack in a space-saving and simple manner, i.e., in an area that is otherwise often required for attaching a drive spindle, which is not necessary here. This peeling disc serves to remove the first flowable phase from the drum.

[0081] It is preferred – because it is structurally simple and safe – that the rotor units for the magnetic bearing devices are arranged at the two axial ends of the drum and that the inlet pipe and the outlet pipe of the first peeling disc each axially pass through one of these two rotor units.

[0082] It is particularly advantageous and practical that the separator insert is designed as a pre-assembled unit. In particular, it can also be provided that all product-contacting elements of this insert are made of plastic or another non-magnetic material, and that the entire unit is replaceable and can be completely disposed of after use. Cleaning and, if necessary, steam sterilization of the separator insert are therefore no longer required.

[0083] The respective bearing arrangement, which provides not only radial bearing but also axial bearing of the drum and / or a rotary drive, can operate permanently and / or electromagnetically.

[0084] On the outer circumference, the inlet pipe or a peeling disc shaft surrounding it is preferably sealed and inserted into the housing or formed integrally with it.

[0085] The drum can be simply conical or double conical. It can also additionally or alternatively have one or more cylindrical sections. Furthermore, it can be composed of several parts, in particular an upper part and a lower part, these parts preferably being joined together after the installation of internal components and their assembly (e.g., by gluing or welding). Similarly, the housing can be composed of several parts, in particular an upper part and a lower part, these parts preferably being joined together after the installation of internal components – in particular the rotor – and their assembly (e.g., by gluing or welding).

[0086] The drains can have spigots on the outside of the housing, which are sealed to the outer circumference, allowing for easy connection of hoses or similar fittings. The hoses can also be pre-assembled on the spigots, ensuring a complete and, if necessary, sterile seal. The spigots can extend, for example, radially, tangentially, or at an angle to the radial direction.

[0087] The entire separator insert can be supplied as a sealed unit after its manufacture, preventing the ingress of contaminants. For this purpose, the ports on the housing openings can be sealed and detachably closed. Hose sections with openable and closable connectors can be attached to these ports, allowing the separator insert to be connected to other elements of the inlet and outlet system, such as bags, tanks, hoses, or pipes.

[0088] These separators are suitable for operation at variable, even relatively high, speeds. They are also well-suited for single-use processing – for example, the centrifugal separation of a batch of free-flowing fermentation broth as a suspension – from, say, 100 liters to several thousand, e.g., 4000 liters – into different phases, after which the product can be disposed of. A particular advantage is that all product-contacting components of the separator can be installed, operated, and subsequently disposed of as a prefabricated and sterile unit. This prefabricated unit consists at least of the rotor with the drum, the separating plates, the inlet distributor, and the rotor magnets or rotor units, as well as the housing with the inlets and outlets. Furthermore, the unit can also include inlet and outlet lines (e.g.,...hoses) as well as measuring equipment or other product-contacting components that are intended for single use and are disposed of together with the separator unit after use.

[0089] Finally, it can be advantageously provided that the housing has only the openings for inlet pipes and outlets and is otherwise hermetically sealed. For this purpose, the inlet pipes and outlets can be designed to protrude from the housing like nozzles, with these nozzles being sealed to the housing or formed integrally with it.

[0090] Each of the recordings can have a separate linear drive for the linear movement of one of the two recordings relative to the separator insert.

[0091] Alternatively, only one of the two fixtures can have a linear drive, with both fixtures being movable simultaneously, preferably synchronously. Simultaneous or synchronous movement can be achieved particularly preferably by a gearbox, e.g., a gear drive, which is part of the separator.

[0092] The frame may have a support plate which allows the separator insert to be temporarily supported when being inserted into the frame.

[0093] The support plate can have a support device, preferably a support strut, particularly preferably a telescopic rod, especially a spring-loaded telescopic rod.

[0094] The support plate has, in particular, a recess for receiving the separator insert. The recess can allow for a complete or partial gripping of the separator insert, e.g., by two prongs. In this context, the recess does not need to be completely closed.

[0095] At least one of the fixtures, preferably each of the fixtures, can have a through-opening through which a hose is guided for product supply and / or discharge, and wherein the fixture is mounted to be linearly movable relative to the hose. The drive, e.g., a motor, is preferably arranged around the through-opening.

[0096] The linear drive can in particular have a driver and a stator, wherein the driver is designed as a slide and is attached to one of the receptacles and wherein the stator is designed as a guide rail and is attached to the frame, preferably to a console of the frame.

[0097] The carrier can be reliably attached to one of the mounts at a time.

[0098] The separator insert can have one or more circumferential stops for resting on the support plate. This could, for example, be a circumferential sleeve that allows for a broad contact area.

[0099] The mountings can be designed to be movable by the same amount, in particular to achieve optimal force absorption during disassembly.

[0100] The invention is described in more detail below with reference to exemplary embodiments and the drawing, and further advantageous variants and embodiments are also discussed. It should be emphasized that the exemplary embodiments discussed below are not intended to provide an exhaustive description of the invention, but that variants and equivalents not shown are also feasible and fall within the scope of the claims. The drawing shows: Figure 1: A schematic, sectional view of a first interchangeable separator insert of a separator, together with a schematic representation of an inlet and outlet system and a control unit of the separator; Figure 2: A schematic, sectional view of a second interchangeable separator insert of a separator, together with a schematic representation of an inlet and outlet system and a control unit of the separator; Figure 3: A schematic representation of a separator with a reusable frame and an interchangeable separator insert, the latter shown here in the manner of Fig. 1 , with hose sections arranged on it; Figure 4: a perspective view of the interchangeable separator insert made of Fig. 1 and 3 with attached hose sections; Fig. 5 - 7 three successive steps when inserting the replaceable separator insert from Fig. 4 into the frame of Fig. 3; Fig. 8 a perspective view of a modification of the separator and the separator insert of the Figs. 1-7 as a further embodiment; Fig. 9 schematic representation of an installation for carrying out a method for replacing a separator insert; Fig. 10 a perspective view of a separator insert in a variation of the variants of Figs. 1-8 with an integrated drainage outlet pipe; and Fig. 11 a further embodiment with a rotor as separator insert and a housing as a fixed, non-replaceable component of the separator; Fig. 12 a further embodiment of a separator insert which has at least one connection port on its housing for supplying or discharging gas; and Fig. 13 a further embodiment of a separator according to the invention with separator insert.

[0101] Figures 1-13The figure shows several separators with a reusable frame I and an interchangeable separator insert II for centrifugal separation. The separator insert can be replaced, in particular, by the various design options. Figs. 9-12 to be implemented, in which a drainage outlet pipe 120 is provided.

[0102] The separator could also be used in accordance with the type of the Fig. 1 or Fig. 2 be designed and may be supplemented by a drainage pipe not shown.

[0103] Separator insert II is preferably designed as a prefabricated unit. In particular, separator insert II is designed as a disposable separator insert that is replaceable or interchangeable as a whole and pre-assembled, and is made entirely or predominantly of plastic or plastic composite materials.

[0104] The separator insert (which does not include elements 4a and 5a) is shown separately as an example in Figure 1 and 2 As shown. It can be disposed of after processing a product batch and replaced with a new separator insert. II can be exchanged.

[0105] After Fig 1 and 2 The separator insert II of the separator comprises a housing 1 and a rotor 2 inserted into the housing 1, which is rotatable relative to the housing 1 during operation. The rotor 2 has an axis of rotation D. This can be oriented vertically, which corresponds to the design of the frame I. However, it can also be oriented differently in space if the frame is designed accordingly.

[0106] The rotor 2 of the separator insert II has a rotatable drum 3. The rotor 2 is rotatably mounted at two locations axially spaced apart from each other in the direction of the axis of rotation, each location having a magnetic bearing arrangement 4, 5. Preferably, the rotor 2, and consequently also the drum 3, is rotatably mounted at both axial ends. The separator insert II The frame I-1 features rotor units 4b, 5b of the magnetic bearing devices 4, 5. Stator units 4a, 5a of the magnetic bearing devices 4, 5 are arranged on the frame I-1.

[0107] The magnetic bearing devices 4, 5 preferably act radially and axially and hold the rotatably mounted rotor 2 preferably in the housing 1 at a distance from it in suspension.

[0108] Such a separator with an easily replaceable separator insert can be useful and advantageous in the processing of products where it can be ruled out with a very high degree of certainty that impurities will be introduced into the product – a flowable suspension or its phases – during centrifugal processing, or where cleaning and disinfection of the separator would be very complex or even impossible.

[0109] The frame I has a console I-1. This console may—but need not—be mounted on a carriage I-2 with rollers I-3. Receptacles I-4 and I-5 may be formed on the console I-1, which serve to receive and hold the separator insert II, even during operation. Preferably, a first axial end of the separator insert II projects from below into or towards the upper receptacle I-4, and a lower end of the separator insert II projects from above into or towards the other receptacle I-5, whereby the separator insert II is held against rotation on the console I-1 and thus on the frame I.

[0110] One or both of the mountings I-4 and / or I-5 can be arranged laterally on the frame I, in particular on the console I-1. In one variant, it can be further provided that, for example, the lower mounting I-5 is fixed to the console I-1. It is then advantageous for the upper mounting I-4 to be height-adjustable on the console I-1.

[0111] In this case, it is advantageous if the console I-1 has such a vertical extension / length that the separator insert is held in a fixed position in the first position of the height-adjustable mount I-4 by both height-adjustable mounts I-4, I-5 and is interchangeable in the other upper position.

[0112] It is advantageously designed so that the mounts I-4 and I-5 with the stator units 4a, 5a on frame I can be moved axially apart and then back together in order to change the separator insert II, i.e., to remove the old separator insert II from frame I and replace it with a new one. This can be implemented, for example, as detailed in Fig. 13 The system is shown with one or more electric linear actuators 50, wherein the stator(s) 55, 56 of each linear actuator 50 are attached to the console I-1 and the driver(s) 53, 54 of the linear actuator 50 or linear actuators 50 are connected to the respective receptacles I-4 and I-5. Such linear actuators 50 are required for larger drive and magnetic bearing assemblies because separating the rotor unit with the permanent magnet from the stator unit requires considerable force.

[0113] The stators 55 and 56 are designed as guide rails. Both mounts, I-4 and I-5, can also be moved by a single linear drive using the additional linear guide. Synchronization of the movement of both mounts is particularly advantageous.

[0114] The drivers 53, 54 can be designed as slides. The drivers 53, 54 are connected to the remaining receptacle I-4 or I-5 via a mechanical interface 51, 52, for example via a flange connection.

[0115] It is therefore provided that the relative distance of the mounts I-4 and I-5 with the stator units 4a, 4b of the bearing devices 4, 5 is adjustable by means of linear drives in order to be able to change the separator insert II.

[0116] To remove the separator insert II, the upper receptacle I-4 is first lifted using the linear actuator of the linear drive, which is, for example, a linear motor. The separator insert II rests on a support plate 57. For this purpose, the separator insert II can have a circumferential sleeve 59 as a stop element. The support plate 57 preferably has two, in particular symmetrical, legs that partially encircle the separator insert II. Alternatively, the support plate 57 can also fully encircle the separator insert II. The support plate 57 is supported on the bracket I-1 by a support strut 58. This support strut 58 can preferably be designed as a telescopic rod.

[0117] Due to its weight and the holding force of the lower drive and magnetic bearing assembly, separator insert II is not lifted and remains on the support plate. Subsequently, the lower receptacle I-5 is lowered by means of the linear motor, with the support plate 57 serving as a counterweight for the force required to separate the stator unit of the lower drive and magnetic bearing assembly from the rotor unit with the permanent magnet. Once receptacles I-4 and I-5 have been moved apart in this manner, separator unit II can be removed.

[0118] Inserting a new separator unit II is done in reverse order. With mounts I-4 and I-5 separated, separator unit II is placed on the support plate 57. Suitable positive locking devices between support plate 57 and separator unit II prevent incorrect positioning of the separator unit. Then, the lower mount I-5 is raised with the linear actuator until the stator unit and the permanent magnet of the rotor unit are correctly positioned relative to each other. Afterward, the upper mount I-4 is lowered with the linear actuator until the stator unit and the permanent magnet of the rotor unit are correctly positioned relative to each other.

[0119] In the respective mounts I-4 and I-5, stator units 4a and 5a of two drive and magnetic bearing units 4 and 5 can be arranged. The control and power electronics for this can be located in or on the frame. I, e.g., located in, on, or at console I-1.

[0120] Corresponding positive locking elements can be provided on the receptacles I-4 and I-5 and on a housing 1 of the separator insert II that does not rotate during operation, in order to insert the separator insert II into the stator units 4a, 5a in a rotationally fixed manner. The upper and lower stator units 4a, 5a can each have axes aligned with each other.

[0121] In a particularly simple variant, the housing 1 and the mounts I-4 or I-5 with the stator units 4a, 5a can have projections (e.g., pins or webs) and recesses (e.g., bores) as corresponding positive locking elements to hold the housing 1 rotationally fixed to the stator units and thus to the frame II. The corresponding positive locking elements can also be formed directly on the frame II.

[0122] The position of these corresponding positive locking elements also defines the functionally required position of the stator units 4a, 5a and the rotor units 4b, 5b relative to each other. This particularly concerns the precise centering of the coaxially nested units 4a, 5a and 4b, 5b. The receptacles can also be used to exert a holding force (from above and below) on the housing in the axial direction, if necessary to secure it by friction.

[0123] After Figs. 3 to 7 The above measures will be implemented as follows, by way of example.

[0124] The mounts I-4 and I-5 with the stator units 4a, 5a of the frame I each have several pins 41a projecting in the axial direction, and the respective separator insert II can have corresponding blind holes extending, for example, in the axial direction as recesses 42 or 41b on the housing 1.

[0125] Here, the receptacle I-4 with the stator unit 4a has axially, or vertically, downwardly projecting pins 41 (not visible here), and the separator insert II has corresponding blind-hole-like recesses 42 vertically at the top (visible here). Similarly, the lower receptacle I-5 with the lower stator unit 5a has axially, or vertically, upwardly projecting pins 41a (visible here), and the separator insert II has corresponding blind-hole-like recesses axially at the bottom (not visible here). By way of example, four pins 41a and four recesses 41b are arranged at the corners of an imaginary polygon, in particular a square, specifically at the top and bottom of receptacles I-4, I-5, and the housing 1 of separator insert II.

[0126] In Figs. 1-7The corresponding positive locking elements 41a, 41b and 42 are arranged circumferentially around the separator insert II. However, it is also possible that only one positive locking element is provided instead of several.

[0127] However, the corresponding positive locking means can also be arranged asymmetrically to ensure that the separator insert can only be used in a single orientation.

[0128] The stator units 4a, 5a can each have openings, in particular through-openings 43, to accommodate lines such as hoses 44, 45 connected to the separator insert II, extending upwards and / or downwards. These are also analogous in Fig. 13 depicted.

[0129] One or both of the mounts I-4 and I-5 are vertically adjustable. One of the two mounts I-4 or I-5 can therefore also be fixed to the frame I. It is also conceivable that one of the two mounts I-4 or I-5 – e.g., the lower one – is attached to a wall of the frame I and is not adjustable. In this case, it is sufficient to design the frame I such that the other mount I-4 or I-5 is adjustable, in particular by being arranged and / or designed to be vertically height-adjustable on the frame I.

[0130] This can be clearly seen from the interplay of the Figs. 3 to 7 .

[0131] Fig. 5 Frame I shows before the insertion of a separator insert. II.

[0132] The two stator units 4a, 5a have been moved so far apart relative to each other that the respective separator insert can be lifted axially between the two mounts with the stator units 4a, 5a ( Fig. 5 ,6 ), whereby the separator insert II is then placed in / on the lower receptacle I-5 ( Fig. 6 and 7 ) that the corresponding positive locking means - here 41, 42 - interlock. In addition, the hose 45 has been guided downwards at the lower end of the housing 1 through the through-opening 43 of the lower - and thus axially associated - stator unit 5a ( Fig. 6 ). Now the upper receptacle I-4 is lowered until the corresponding positive locking means of the upper receptacle I-4 and the housing 1 of the separator insert I - here 41, 42 - also engage securely ( Fig. 7The upper hoses 44 are guided through the through-opening 43 of the upper receptacle I-4 on the housing 1. The separator insert II is now securely and rotationally fixed to the frame I. Therefore, the centrifugal spinning and separation process for processing a batch of product can begin in the centrifugal field. After processing the intended batch, the upper separator unit is lifted back up until it can be removed from the frame I and replaced with a new one.

[0133] The following refers to Figure 1 and Fig. 2 The further construction of exemplary preferred separator inserts II, including the construction of the drive and bearing system of the separator, the control system of the separator, and the inlet and outlet system of the separator, is described in more detail. The invention is not limited thereto. In particular, the inlet and outlet connections can also be implemented differently on the separator insert II.

[0134] Firstly, the rotor units 4b, 5b can be designed essentially in the manner of inner rings made of magnets, in particular permanent magnets, and the reusable stator units 4a, 5a can be designed essentially in the manner of outer rings, which are used for the axial and radial support of the rotor 2 (e.g. top) or alternatively also for the rotary drive (e.g. bottom).

[0135] Thus, rotor units 4b and / or 5b, as part of the separator drive, also constitute part of the rotating system or rotor. In other words, the drive rotor is part of the centrifugal separator drum.

[0136] One or both of the magnetic bearing devices 4, 5 are thus preferably also used as a drive device for rotating the rotor 2 with the drum 3 in the housing 1. In this case, the respective magnetic bearing device forms a combined magnetic bearing and drive device. The magnetic bearing devices 4, 5 can be designed as axial and / or radial bearings, which together axially and radially support the drum 3 at its ends during operation, thus keeping it suspended and rotating it.

[0137] The magnetic bearing units 4 and 5 can be fundamentally identical or largely identical in their design. In particular, only one of the two magnetic bearing units 4, 5 can also be used as a drive device. Thus, corresponding components of the magnetic bearing units 4, 5 are located on the separator insert II – on its rotor 2 – and other corresponding parts are located on the frame I. One or both stator units 4a, 5a can also be electrically connected to control and power electronics for controlling the electromagnetic components of the magnetic bearing units.

[0138] The respective magnetic storage device 4, 5 can, for example, operate according to a combined electro- and permanent magnetic principle.

[0139] Preferably, at least the lower axially acting magnetic bearing device 5 serves to keep the rotor 2 axially suspended within the housing 1 by levitation. It can have one or more first permanent magnets, for example, on the underside of the rotor, and furthermore, electromagnets mounted on a receptacle on the frame, which coaxially surround the permanent magnet(s). The rotor can be driven electromagnetically. However, a drive via rotating permanent magnets is also feasible.

[0140] Such bearing and drive devices are used, for example, by the company Levitronix for driving centrifugal pumps (EP2 273 124 B1). They can also be used in the context of this document. For example, a first Levitronix motor "Below" can be used as the drive, which simultaneously provides radial and axial magnetic bearings for the drum. In addition, a second Levitronix motor – identical in construction except for the control system – can be provided, which, as the magnetic bearing 4, can provide radial and axial bearings for the rotor 2 at the head.

[0141] The rotor speed can be controlled by a control device 37 (see Fig. 1 or 2 ) or a separate control unit for the magnetic bearings 4, 5 can be variably adjusted. The direction of rotation of the rotor 2 can also be preset and changed in this way.

[0142] During operation, the rotor 2 rotates. This keeps it axially suspended and radially centered. Preferably, the rotor 2 is operated with the drum 3 at a speed of between 1,000, preferably 5,000 to 10,000, and optionally up to 20,000 revolutions per minute. The centrifugal forces generated by the rotation lead to the separation of a suspension to be processed into different flowable phases LP and HP of different densities, as described above, and to their discharge, as described in more detail below. The product batch is processed continuously, meaning that the phases separated from the suspension are completely discharged from the drum during operation.

[0143] This makes it very feasible to create a separator insert and housing that can be designed for single use. This is particularly interesting and advantageous for processing pharmaceutical products such as fermentation broths or similar substances, as the entire separator insert is replaceable. This is because, after processing a batch of the product, preferably during continuous operation, the drum does not need to be cleaned. Individual components such as magnets can also be recycled (see also DE 10 2017 128 027 A1).

[0144] The housing 1 preferably consists of a plastic or a plastic composite material. The housing 1 can be cylindrical and have a cylindrical outer shell, at the ends of which two radially extending limiting walls 6, 7 (lid and bottom) are formed.

[0145] The drum 3 serves for the centrifugal separation of a flowable suspension S in the centrifugal field into at least two phases LP, HP of different densities, which can be, for example, a lighter liquid phase and a heavier solid phase or a heavier liquid phase.

[0146] In a preferred embodiment, the rotor 2 and its drum 3 have a vertical axis of rotation D. However, the housing 1 and the rotor 2 could also be oriented differently in space. The following description refers to the vertical orientation shown ( Fig. 3 If the orientation in the room changes, the orientations will also change accordingly. Furthermore, one or both outlets may be arranged differently – this is still to be discussed.

[0147] The rotor 2 of the separator with the drum 3 preferably consists entirely or predominantly of a plastic material or a plastic composite material.

[0148] The drum 3 is preferably designed to be cylindrical and / or conical, at least in sections. The same applies to the other elements in the rotor 2 and on the housing 1 (except for elements of the magnetic bearing devices 4, 5).

[0149] The housing 1 is designed in the manner of a container, which is advantageously hermetically sealed except for some openings / opening areas (to be discussed later).

[0150] After Fig. 1 and 2 In each of the two axial boundary walls 6, 7, which are located above and below as examples, one of the openings is formed in the container 1.

[0151] One of the openings – in the first, here upper axial boundary wall 6 – enables or serves according to Fig. 1 and 2 as inlet 8 for feeding a suspension to be separated in a centrifugal field into at least two phases of different density - LP and HP - through the housing 1 to the drum 3.

[0152] Here, the first phase is a lighter phase LP and the second phase is a denser, heavier phase HP compared to the first phase.

[0153] A second of the openings - in the second, here lower axial boundary wall 7 - allows or serves as a drain for the second heavier phase HP directly from the drum 3 through the housing 1.

[0154] Drum 3 also has openings that correspond to the openings of the housing.

[0155] A feed pipe 12 for a suspension to be processed extends into an upper opening 12a at one axial end of the drum 3. This pipe passes through the housing 1, in particular through one of its axial boundary walls 6 – here the upper one. The feed pipe 12 extends towards the housing 1 at its outer circumference. Fig. 1The inlet pipe 12 is sealed and inserted into the housing – e.g., by welding or gluing – or optionally manufactured as a single piece with the housing as an injection-molded plastic part. It is preferably also made of plastic. The inlet pipe 12 protrudes from the housing 1 at the top and extends through the upper boundary wall 6 into the drum 3, without touching the drum 3.

[0156] The inlet pipe 12 passes through after Fig. 1 (but also Fig. 2 ) concentric to the axis of rotation of the rotor 2 the housing 1 and the one magnetic bearing 4, then extends axially further inside the housing 1 into the rotatable drum 3 and ends there with its other end - a free outlet end.

[0157] The inlet pipe 12 leads to Fig. 1 and 2Each component is contained within the drum 3 in a distributor 13 that is rotatable with the drum 3. The distributor 13 has a tubular distributor shaft 14 and a distributor base 15. One or more distributor channels 16 are formed in the distributor base 15. A stack of separating plates, in this case conical, 17, can be placed on the distributor 13. The distributor 13 and the separating plates 17 are preferably also made of plastic.

[0158] Furthermore, both serve after Fig. 1 as well as after Fig. 2 Each has a first peeling disc 33 for draining the heavier phase HP of the two phases HP and LP from the drum 3. A peeling disc shaft or a central drain pipe 34 penetrates the second axial boundary wall 7 (see Fig. 1 and Fig. 2 ).

[0159] In one possible – but not mandatory – embodiment, the drum 3 has at least two cylindrical sections 18, 19 of different diameters. Adjacent to these, one or more conical transition regions may be formed on the drum 3. The drum 3 may also be generally single or double conical in its central axial region (not shown here).

[0160] As shown, the drum 3 can have a lower cylindrical section 20 of smaller diameter, on / in which the rotor unit 5b of the lower magnetic bearing is also formed, which transitions into a conical area 20a, then here, for example, a cylindrical area 19 of larger diameter, then again a conical area 18a and then an upper cylindrical section 18 of smaller diameter, on which the rotor unit 4b of the upper magnetic bearing 4 is formed.

[0161] With regard to the removal of the lighter phase, the separator inserts differed. Fig. 1 and 2 .

[0162] Openings (which may be provided circumferentially distributed on drum 3, whereby several openings may therefore be provided on drum 3) serve according to Fig. 1 as radial or tangential outlets 21 of the light phase LP from the drum 3. An opening in the outer casing allows, according to the exemplary embodiment of the Fig. 1 then the outlet or serves as the outlet 10 of the lighter product phase LP formed during centrifugal separation, which has been discharged from the drum 3.

[0163] The first outlets 21 on the radius ro of the drum 3 are designed as nozzle-like openings in the outer shell of the drum 3. They are also designed as so-called "free" outlets from the drum 3. These first outlets 21 serve to discharge the lighter phase LP. The outlets can be designed so that the lighter phase exits radially, or alternatively, they can be shaped so that the lighter phase exits tangentially against the direction of rotation of the drum, thus contributing to the drive of the rotor and reducing the drive energy. This phase exiting the drum 3 is collected in the housing 1 in an upper annular chamber 23. This annular chamber 23 is designed such that the phase collected within it is directed to the outlet 10 of the annular chamber 23. This is achieved by positioning the outlet 10 at the lowest point of the annular chamber 23.The collecting ring chamber 23 is open radially inwards towards the rotating drum 3 and is spaced such that liquid ejected from the respective outlet 21 during centrifugal separation is essentially only injected into the associated collecting ring chamber 23, which is located at the same axial level.

[0164] Below the trap ring chamber 23, a chamber 25, not used for phase discharge, can optionally be provided. This chamber 25 can optionally have a leakage drain (not shown here). The leakage can drain freely. However, it can also be extracted by negative pressure if the chamber 25 has a negative pressure connection for connecting a negative pressure generating device.

[0165] The first trap ring chamber 23 and the chamber 25 can be separated from each other by a first conical wall 26, which extends conically inwards and upwards from the outer shell of the housing 1 and ends radially in front of the drum 3, spaced apart on the inside.

[0166] Preferably at the lowest point of the trap ring chamber, the product phase LP The flow is discharged through the outlet 10 from the housing 1. Connections may be provided on the outside of the housing 1 in the area of ​​the outlet 10 to allow for easy connection of pipes, hoses, and the like.

[0167] These components can be directly integrated into the housing 1 or attached to it by adhesive bonding. The nozzles are preferably also made of plastic. The housing 1 can be composed of several plastic parts that are sealed together, for example, by adhesive bonding or welding.

[0168] As (here second) outlet for the more severe phase HP from the drum (through the housing 1) is after Fig. 1 and 2 The first peeling disc 33 is provided, extending essentially radially and transitioning into an axially extending outlet pipe 34 as a peeling disc shaft, which penetrates the lower axial boundary wall 7 of the housing 1. The peeling disc 33 has an outer diameter ru, where ru > ro. The inlet openings 33a of the peeling disc 33 are therefore located on a larger diameter or radius ru than the outlets 21 for the lighter phase LP on radius ro. This makes it possible to use the peeling disc 33 to extract a heavier phase HP from the drum 3, relative to the lighter phase LP. During operation of the separator, the peeling disc 33 remains stationary and its outer edge is immersed in the heavier phase HP rotating in the drum 3.

[0169] The channels in the peeling disc 33 direct the HP phase inwards. The peeling disc 33 thus serves to direct the HP phase in the manner of a centripetal pump.

[0170] The peeling disc 33 can be arranged in a simple and compact manner in the drum 3 below the distributor 14 and below the plate pack 17. The radius ru corresponds to the immersion depth of the peeling disc 33.

[0171] The drain pipe 34 extends downwards from the housing 1 and through the lower boundary wall 7, without touching the drum 3. The drain pipe 34 can be formed integrally with the housing 1 or be sealed within it. A hose or similar component can be connected to the drain pipe as a drain 35.

[0172] The discharge tube passes concentrically to the axis of rotation D of the rotor 2 through the housing 1 and the lower magnetic bearing 5, and then extends axially further within the housing 1 into the peeling disc 33.

[0173] It can be provided that a controllable, especially electrically controllable, control valve 36 is installed in the outlet for the heavy phase HP, in particular in the branch 35 for the heavier phase HP. The control valve 36 allows the volume flow of the heavy phase HP in the branch 35 to be throttled and the immersion depth of the associated peeling disc to be increased. A control device 37 is preferably provided. The control valve 36 is preferably connected to the control device 37 wirelessly or via a wired connection.

[0174] The control unit 37 can also be designed and provided for controlling the magnetic bearings 4, 5 and the drive.

[0175] After Fig. 2The light phase LP is also discharged via a peeling disc.

[0176] For this purpose, a peeling disc 22 is provided in the upper area of ​​the drum 3, the inlet openings 22a of which can again be located on a smaller radius ro than the radius ru of the inlet of the first - lower - peeling disc 33 for the heavier phase.

[0177] The shaft of this peeling disc 22 can surround the inlet pipe 8 in an annular channel like an outer drain pipe 24 and be tightly connected to the housing 1 instead of the inlet pipe 8 or be formed integrally with it. The drain pipes 24, 34 of the two peeling discs 22, 33 are thus according to Fig. 2The inlet pipe 12 extends from opposite ends of the drum 3. It also extends from opposite ends of the housing 1. It can be sealed and inserted into the housing 1, or it can be integrally formed with the housing and made of plastic. The inlet pipe 12 can be connected to the upper end of the peeling disc shaft 24. A radial or tangential connection 24a can extend from the peeling disc shaft 24. A drain 40 for discharging the light phase can be connected to this connection, leading, for example, into a bag or tank. Similarly, the ends of the pipes 12 and 34 can also be designed as connections for hoses or the like. Fig. 2 , but also Fig. 1 ).

[0178] It may be provided that derivative 40 also includes the light phase LP a controllable, in particular electrically controllable, control valve 39 is used.

[0179] The control valve 39 allows the flow rate of the light phase LP to be changed, in particular by throttling it more or less, and thus the immersion depth of the second peeling disc 22 to be altered. The control valve 39 is also wirelessly or wired connected to the control device 37, so that it can be controlled by the control device 37.

[0180] The respective peeling discs 22 and 33 are cylindrical discs with several channels, for example one to six, and are essentially radially oriented. During operation, the discs remain stationary and their channels form a type of centripetal pump. The outer edge of each peeling disc 22 or 33 immerses itself in the rotating phase LP or HP within the separator. The channels in the peeling disc direct the respective phase LP or HP inwards, converting its rotational speed into pressure. The peeling discs 22 and 33 thus replace a discharge pump for the respective phase LP or HP. The peeling discs therefore function as centripetal pumps. They can be made of plastic.

[0181] Theoretically, a third peeling disc could also be provided, which could serve to derive a further phase.

[0182] The operation of the separators is described below. Fig. 1 and then after Fig. 2 briefly described.

[0183] First, the respective separator with its reusable components is provided. This includes the frame I as well as the drive and stator units 4a and 5a of the magnetic bearing devices. A control unit 37 is also included. Next, a separator insert II is provided and mounted on the frame I. This only requires moving the stator units 4a and 5a apart. The separator insert is then positively engaged, and the stator units are moved towards each other. This securely holds the housing in place. Finally, hoses leading into tanks or bags are connected to the nozzles, if necessary. The respective separator insert of the Fig. 1 and 2It may therefore preferably also have hoses and fittings that can be connected to (not shown here) other lines and containers such as bags, tanks, pumps and the like.

[0184] Then, after connecting the lines, hoses, etc., a suspension is fed into the rotating drum (inlet 8) and there centrifugally separated into the light phase LP and the heavy phase HP.

[0185] The heavier phase HP, with its higher density, flows radially outwards in the separation chamber of the drum 3. There, the phase HP leaves the drum at a radius ru through the channels of the stationary peeling disc 33.

[0186] The lighter phase LP flows radially inwards in the separation chamber of the drum 3 and rises through a channel 38 on a shaft of the distributor. There, the phase LP leaves the drum after Fig. 1 and 2 each on a radius ro.

[0187] The control valve(s) 36, 39 allow for simple influence on the separation process. This results in an optimization of the separation process.

[0188] The primary application of the separator is cell separation in the pharmaceutical industry. Its capacity is designed for processing broths from fermenters ranging in size from 100 to 4000 liters, as well as for laboratory applications.

[0189] Other industrial sectors where separators are used are also conceivable: chemicals, pharmaceuticals, dairy technology, renewable raw materials, oil and gas, beverage technology, mineral oil, etc.

[0190] The separators shown enable the production of a separator insert in which preferably all product-contacting components can be made of plastic or other non-magnetic materials that can be disposed of or recycled after a single use. Cleaning after use is therefore unnecessary. The separator and its operation can thus be implemented cost-effectively.

[0191] Fig. 8 shows a modification of separator insert II of the Figs. 1-7In a second embodiment, identical features are provided with analogous reference numerals. The special feature of this second embodiment is that the positive locking means 41a and the corresponding positive locking means 41b provided on the frame I are only provided on one side between the frame I and the separator insert II, thereby also enabling axial and rotational locking of the separator insert II relative to the frame I. This reduces, among other things, the complexity of the assembly.

[0192] The use of the in Figs. 1-8 The modular centrifugal separator shown, with its replaceable separating insert, ensures a sterile interior, i.e., a sterile flow path within the centrifugal separator.

[0193] Suitablely, in separators with product inlet and outlet systems and drainage systems, consisting of separator inserts, inlet systems and outlet systems, other interchangeable components can also be used to provide a sterile flow path for the inlet suspension and the separated light and heavy phases.

[0194] To give just a few examples, the pump for the inlet suspension, the inlet tubing, the tubing for the light and heavy phases, and the receiving container for the heavy phase can all be interchangeable sterile components suitable for separating a single product batch or a limited number of product batches. The tubing for the drainage fluid, as well as the drainage fluid container, can also be interchangeable sterile components. All these components are connected to each other with sterile connectors to allow for easy and sterile component replacement. The product inlet system, the product outlet system, and the drainage system of the separator are described below using the following examples: Fig. 9To explain in more detail: A single-use centrifugal pump 101 can be used in the inlet. This has the advantage of being smaller than comparable peristaltic pumps while offering the same flow rate. The pump delivers a specific volume depending on its speed and the existing back pressure.

[0195] The flow meter 102, also located in the inlet line between pump 101 and separator insert II, preferably operates using a non-contact measuring principle, e.g., an ultrasonic transit-time difference method. This allows it to be simply slid along the inlet line without coming into contact with the product.

[0196] It can therefore be reused continuously, while the inlet hose is a single-use product. The flow meter's signal is used to control the speed of the inlet pump. In this way, a controller can adjust the inlet pump's speed so that the preselected setpoint for the inlet flow rate matches the measured actual value. The pump and flow meter are positioned in the rising inlet line, ensuring the line is always filled with liquid, resulting in a more stable reading from the flow meter 102.

[0197] A pump 110 and a flow meter 111 are arranged in the discharge line for the heavy phase. The pump and flow meter are located in the rising discharge line, so that the line is always filled with liquid, resulting in a more stable reading from the flow meter 111.

[0198] The drain pump 110 is preferably designed as a peristaltic pump. One advantage of a peristaltic pump is that it only comes into contact with the outside of the drain hose and not with the product itself.

[0199] It can therefore be reused continuously, whereas the drain hose is a single-use product. Another advantage of the peristaltic pump is that it delivers a defined volume depending on the speed. Unlike the centrifugal pump, it can be used as a throttle, i.e., it can generate pressure in the discharge of the heavy phase, the level of which can be regulated by the control system. Accordingly, the necessary pressure sensors can be provided in individual or, preferably, all hose lines (not shown in the image).

[0200] A container 105, serving as a buffer tank, is provided in the discharge line for the light phase. A load cell 104 determines the quantity of light phase currently in the buffer tank and transmits this information to the control system.

[0201] The light phase from separator insert II can be introduced into container 105 either in the upper part of the container (above the established liquid level) or in the lower part of the container (below the established liquid level). For products that tend to foam, the upper introduction has proven effective. The outlet of container 105 is connected to a downward-sloping drain hose, which passes through an optical sensor 106 and a peristaltic pump 107.

[0202] The pump speed is optimally controlled using the measurement signal from the load cell 104 so that the container 105 is never completely full and never completely empty. This ensures that the drain hose is always filled, resulting in a stable signal from the optical sensor 106. The signal from the optical sensor 106 is used to assess the quality of the light phase. For example, the amount of remaining turbidity and suspended solids can be evaluated. The pump 107 can be configured as either a centrifugal pump or a peristaltic pump. The volume of the container 105 must be selected so that the residence time of the light phase in the container is sufficiently long for bubbles to separate from the liquid. Using the measurement from the load cell 104, the flow rate of the pump 107 can be adjusted to maintain a constant fill level approximately in the middle of the container 105.

[0203] The downward-sloping drain hose connected to the drainage outlet of separator insert II leads into a container 109, which in turn is suspended from a load cell 108. This allows the amount of drained liquid to be determined. Drainage liquid is primarily generated when the drum comes to a standstill at the end of batch processing and empties via this outlet.

[0204] All hose lines of the Fig. 9 each then leads into a sterile coupling 112. Not shown in Fig. 9 The frame for holding the separator insert and the drive unit are included.

[0205] The in Fig. 9 The illustrated product inlet system PZS, product outlet system PAS, encompassing the product outlets of the heavy and light phases and the drainage system PS, are separated from each other outside the separator insert and are therefore hermetically sealed.

[0206] Fig. 10shows a modification of the first variant of the separator insert II of the Figs. 1-8 for connection to the drainage system of the Fig. 9 The separator insert II has a drainage outlet 120. This is located in the base area 121 of the separator insert and has liquid outlets 122 and 123 from both the drum and the housing. The remaining components are identical to previous versions.

[0207] Fig. 11Figure 1 shows a second variant of a separator insert III, which is interchangeable. This separator insert III has a bottom inlet via the inlet line 61 and the distributor 70 into the disc stack 67. The product inlet line 61 includes an inlet nozzle 73, which extends from the bottom of the housing 68 into the interior of the rotor 65 and opens into a distributor chamber 78 of a holding device 77 of the disc stack 67. The holding device 77 can have a longitudinal axis that is parallel to the axis of rotation of the rotor 65. The channel-like distributor 70 extends from the distributor chamber 78, allowing radial conveyance of the supplied feed product into a separation zone of the rotor 65.

[0208] The product process 62 of the light phase proceeds analogously to Figs. 1-10The product flow 63 of the heavy phase is carried out by conveyance via channels in a separating plate 69, here as a closed-walled separating plate at the end of the plate assembly, and finally by a gripper 64 into a discharge through the product line of the product flow 63. At the separating plate, a separation occurs between the heavy phase and the light phase, whereby the heavy phase is conveyed outwards around the plate and the light phase is guided inside the plate and discharged. However, this is only one of many possible variations of a product flow for the heavy phase.

[0209] Separator insert III can be designed such that the rotor 65, in particular the drum 66 and the disc assembly 67, can be removed from the housing 68. Even with this variant, it is recommended to empty the rotor, especially the drum, of any residual liquid before removing the rotor in the present process. In this case, this can be done via the inlet line 61.

[0210] It is then recommended to also replace the inlet line 61 when replacing the separator insert III, in order to prevent cross-contamination of subsequent batches. Accordingly, the inlet line can be replaced and securely attached to the housing using seals (not shown), e.g., sealing sleeves, in a medium-tight manner.

[0211] The Fig. 11can be modified in many ways, but shows in particular that it allows for the replacement of the separator insert, which can also be applied to a separator in which only the rotor with its product inlet and outlet lines is designed as an interchangeable separator unit III.

[0212] The housing 68 can be opened (not shown), for example by having part of the housing serve as a lid. For this purpose, preferably at least the upper part of the lid must be removed.

[0213] In Fig. 11The residual liquid is drained via the drainage line 120 and a connected pipe element 71, in particular a discharge element in the form of a hose attached to or fitted to it, into a collection container 74. The inlet line 61, in particular the inlet nozzle 72, is connected to a supply element 72, which is connected to a container 75 containing the suspension of the starting product. A switching valve (not shown) can be arranged in this pipe element, which switches between two containers 75, e.g., to add a demulsifier to improve the suspension. Alternatively, the valve can be closed and the pipe elements and containers exchanged.

[0214] Furthermore, the supply element can have a pump, e.g. a peristaltic squeeze pump, so that the liquid in the supply element is not passed through the pump itself.

[0215] Fig. 12Figure 1 shows another variant of a separator insert II, which can be provided as part of a process for its replacement. This separator insert II has at least one connection port 76 on its housing 1. Through this connection port, the separator insert can be filled with an inert gas before the product to be separated enters the separator insert. In this way, the product to be separated does not come into contact with air or oxygen. A second connection port 76 can be provided on the housing 1, which is intended for venting gases from the separator insert, thus enabling the separator insert to be purged with inert gas.

[0216] The gas can also be extracted from the otherwise hermetically sealed separator insert via the connection nozzle 76 in such a way that a negative pressure is created in the separator insert, which not only reduces the contact with the remaining oxygen, but also reduces the frictional power of the rotating drum 66, which now rotates in an atmosphere of lower density.

[0217] Alternatively, in addition to a protective gas, a pressurized gas, e.g. compressed air, can also be introduced via one or more of the gas connections 76, which further facilitates the emptying of the housing via the drainage line. Reference sign frame I console I-1 Dare I-2 Roll I-3 Recordings I-4, I-5 Separator insert II Housing 1 rotor 2 drum 3 Magnetic storage systems 4, 5 Stator units 4a, 5a Rotor unit 4b, 5b radial boundary wall 6, 7 Inflow 8 Sequence 10 Inlet pipe 12 opening 12a Distribution 13 Distribution 14 Distributor foot 15 Distribution channel 16 Separating plate 17 cylindrical sections 18, 19, 20 con. sections 18a, 20a Outlets 21 peeling disc 22 Inlet openings 22a Catching ring chamber 23 drain pipe 24 Connection piece 24a chamber 25 Conical wall 26 peeling disc 33 Inlet openings 33a drain pipe 34 Derivation 35 Control valve 36 Control unit 37 channel 38 Control valve 39 Derivation 40 pens 41a Exclusions 41b Exclusions 42 Passage opening 43 Hoses 44, 45 Linear actuator 50 mechanical interface 51, 52 drive 53, 54 stator 55, 56 support plate 57 support strut 58 cuff 59 pump 101 Flow meter 102 load cell 104 container 105 Optical sensor 106 Hose pump 107 load cell 108 container 109 pump 110 Flow meter 111 Sterile coupling 112 Drainage pipe 120 floor area 121 Fluid drainage 122 Fluid drainage 123 Separator insert III Inlet pipe 61 Product process (light phase) 62 Product process (critical phase) 63 Grabber 64 rotor 65 drum 66 Plate package 67 Housing 68 Separating plate 69 Distribution 70 Conduit element 71 Supply element 72 Support 73 Collection container 74 container 75 Connection piece 76 Holding device 77 Distribution room 78 axis of rotation D suspension S phases LP, HP Radii ro, ru PAS Product flow system PZS Product feed system DS Drainage system

Claims

1. Separator, comprising a frame (I) comprising receptacles (I-4, I-5) for the rotatable mounting of a separator insert (II, III), each with a stator unit (4a, 5a) as a partial element of a magnetic bearing device (4, 5), and a separator insert (II, III) is provided as a pre-assembled, replaceable unit for insertion into stator units (4a, 5a) on the frame (I) of the separator, and wherein the separator insert (II, III) has at least the following: i. a rotor (2, 65) rotatable about a rotational axis (D) with a drum (3, 66) and a drum wall, ii. at least two rotor units (4b, 5b) as partial elements of the magnetic bearing devices (4, 5) at two axially spaced locations of the rotor (2) with the drum, with which the rotor (2) with the drum (3) can be held in suspension, rotatably mounted and set in rotation within a housing (68) of the separator insert (II, III) during separation operation, characterized in that the separator has at least one linear drive (50) for linear movement of at least one of the two receptacles (I-4 and I-5) relative to the separator insert (II, III).

2. Separator according to claim 1, characterized in that the separator insert (II, III) has at least one product feed line and two product discharge lines.

3. Separator according to one of the preceding claims 1 or 2, characterized in that it has a separating means arranged in the drum (3).

4. Separator according to one of the preceding claims, characterized in that the product-contacting areas of the separator insert (II) are made partially or completely of plastic.

5. Separator according to one of the preceding claims, characterized in that the drum wall is of closed-wall design in a central region of the drum (3, 66).

6. Separator according to one of the preceding claims, characterized in that each of the receptacles (I-4 and I-5) has a linear drive (50) for linear movement of one of the two receptacles (I-4 and I-5) relative to the separator insert (II, III).

7. Separator according to one of the preceding claims 1-5, characterized in that only one of the two receptacles (I-4 and I-5) has a linear drive (50), wherein the two receptacles (I-4 and I-5) can be moved simultaneously, preferably synchronously, wherein the separator particularly preferably has a gear for simultaneous movement.

8. Separator according to one of the preceding claims, characterized in that the frame (I) has a support plate (57) for temporarily supporting the separator insert (II).

9. Separator according to claim 8, characterized in that the support plate (57) has a support device, preferably a support strut (58), particularly preferably a telescopic rod.

10. Separator according to one of the preceding claims, characterized in that the support plate (57) has a recess for accommodating the separator insert (II).

11. Separator according to one of the preceding claims, characterized in that at least one of the receptacles (I-4 or I-5), preferably each of the receptacles (I-4 and I-5), has a through-opening (43) through which a hose (44, 45) for feeding and / or discharging the product is guided, and wherein the receptacle (I-4 or I-5) is mounted so as to be linearly movable relative to the hose (44, 45).

12. Separator according to one of the preceding claims, characterized in that the linear drive has a driver (53, 54) and a stator (55, 56), wherein the driver (53, 54) is designed as a carriage and is fastened to one of the receptacles (I-4 or I-5) and wherein the stator (55, 56) is designed as a guide rail and is fastened to the frame (I), preferably to a bracket (I-1) of the frame.

13. Separator according to one of the preceding claims, characterized in that the driver (53, 54) is attached to one of the receptacles (I-4 or I-5) in each case.

14. Separator according to one of the preceding claims, characterized in that the separator insert (II) has one or more circumferential stops to rest on the support plate (57), in particular a circumferential collar (59).

15. Separator according to one of the preceding claims, characterized in that the receptacles (I-4 or I-5) are designed to be movable by the same amount.