MELANOGENESIS INHIBITOR WITH D-PANTOTHENYL ALCOHOL AND SKIN LIGHTENING COSMETICS WITH THE MELANOGENESIS INHIBITOR

Description

Technical Field

[0001] The present invention relates to the use of compounds for enhancing the skin-whitening effect of D-pantothenyl alcohol.Background Art

[0002] D-pantothenyl alcohol is an alcohol type derivative of a pantothenic acid and is a substance that is converted into vitamin B5 (pantothenic acid) in the body. It has also been used as a material for skin external preparations since long ago, and many skin external preparations containing D-pantothenyl alcohol have been proposed.

[0003] For example, Patent Literature 1 mentions that a skin cosmetic containing D-pantothenyl alcohol improves rough skin, particularly dry skin, and conditions skin quality.

[0004] Patent Literature 2 also mentions that a hair cosmetic containing D-pantothenyl alcohol makes the firmness, body, and smoothness of hair better. JP 2007-176810 A1 relates to compositions for skin-whitening and EP 2380567 A discloses inhibitors of melanin production.Citation ListPatent Literature

[0005] Patent Literature 1: Japanese Patent Application Laid-Open No. 2012-41302 Patent Literature 2: Japanese Patent Application Laid-Open No. 2012-167042 Summary of InventionTechnical Problem

[0006] The present invention provides a new application for the aforementioned D-pantothenyl alcohol.Solution to Problem

[0007] The present inventors have found from experiments that D-pantothenyl alcohol has a melanogenesis inhibitory action, and have completed the present invention. In other words, the present invention relates to the use of a compound for enhancing the skin-whitening effect of D-pantothenyl alcohol in a cosmetic composition.Advantageous Effects of Invention

[0008] According to the present invention, a use of a compound and / or a salt thereof for enhancing the skin-whitening effect of D-pantothenyl alcohol in a cosmetic composition is provided.Brief Description of Drawings

[0009] Fig. 1 (not according to the invention) is a graph illustrating a melanogenesis inhibitory action of D-pantothenyl alcohol in an experimental example. Fig. 2 (not according to the invention) is a graph illustrating a keratinocyte cell proliferation action of D-pantothenyl alcohol in an experimental example. Description of Embodiments

[0010] The present invention will be described below in detail, and of course, the present invention is not limited to only the specific embodiments.

[0011] D-pantothenyl alcohol is a compound represented by the following structural formula (1).

[0012] D-pantothenyl alcohol is used as a material for skin external preparations such as cosmetics, there is no difficulty in availability, and it is possible to use a commercially available product as appropriate.

[0013] The present inventors conducted the experiments described below, and have found from the results that D-pantothenyl alcohol has a melanogenesis inhibitory action in addition to a keratinocyte cell proliferation action.<Experiment 1 (not according to the invention): Melanogenesis Inhibition Experiment>

[0014] According to the method described below, 2-thiouracil ( 14< C-labeled 2-thiouracil in the present test) which is specifically incorporated into melanin in the melanin synthesis process within cells was used to evaluate the melanogenesis inhibitory action. With a complete medium for melanocyte culture (Invitrogen Corporation) used in a 24-well plate, human normal melanocytes (Kurabo Industries, Ltd.) were seeded in each well at a concentration of 6.0 × 10 4< cells / well / 0.5mL. Under a 5% carbon dioxide atmosphere, the culture was conducted at 37°C for 24 hours. Then, replacement was made such that a 0.5 mL medium containing D-pantothenyl alcohol at 0 mM or 1 mM was in each of three wells for each concentration and, to these nine wells, 0.5 µCi / well of 2-[2- 14< C] thiouracil (Daiichi Clarity Co., Ltd.) was further added. And it was further cultured for 3 days under the same conditions as the aforementioned culture conditions. After completion of the culture, the culture medium was removed from each well, which was washed with PBS (phosphate-buffered saline), and the number of cells was measured using the WST-8 reagent (Dojindo Laboratories). The WST-8 reagent was removed from each well, which was washed with PBS, and using 100 (w / v)% trichloroacetic acid (Wako Pure Chemical Industries, Ltd.), the cells were separated from the bottom of the wells, to which water was then added for dilution so that the concentration of the trichloroacetic acid could be 10 (w / v)%, and which were allowed to stand in a refrigerator for 30 minutes. After the cells were recovered by centrifugation, the amount of 14< C-thiouracil in the cells recovered from each well was measured with a liquid scintillation counter (Aloka Co., Ltd.).

[0015] Relative to the radiation doses of the cells cultured in the media containing 0 mM D-pantothenyl alcohol (control), the radiation doses of the cells cultured in the media containing 1 mM D-pantothenyl alcohol were each obtained in percentage as the amount of melanin (%). In other words, it is possible to determine that the smaller the radiation dose incorporated into each cell is, the smaller the amount of melanin is, and accordingly, it is possible to determine that the melanin inhibition titer of the added ingredient is larger. The results are shown in Fig. 1.<Experiment 2 (not according to the invention): Keratinocyte Cell Proliferation Experiment>

[0016] According to the method described below, the cell proliferation promoting action was evaluated. With a complete medium for keratinocyte culture (Kurabo Industries, Ltd.) used in a 24-well plate, human normal keratinocytes (Kurabo Industries, Ltd.) were seeded in each well at a concentration of 1.0 × 10 4< cells / well / 1mL. Under a 5% carbon dioxide atmosphere, the culture was conducted at 37°C for 24 hours. Then, replacement was made such that a 1 mL medium containing D-pantothenyl alcohol at 0 µM, 15 µM, or 150 µM was in each of three wells for each concentration. And it was further cultured for 2 days under the same conditions as the aforementioned culture conditions. After completion of the culture, 20µL of the WST-8 reagent (Dojindo Laboratories) was added to each well, and color reaction was allowed at 37°C for 3 hours. After the reaction, absorbances at 450 nm and 650 nm were measured using a microplate reader, Benchmark Plus (Bio-Rad Laboratories), and the 450 nm absorbance measurement minus the 650 nm absorbance measurement was calculated to give a cell proliferation measurement.

[0017] Relative to the cell proliferation measurements for the wells cultured in the media containing 0 µM D-pantothenyl alcohol (control), the cell proliferation measurements for the wells cultured in the media containing D-pantothenyl alcohol were each obtained in percentage as a cell proliferation rate (%). In other words, it is possible to determine that the larger the absorbance value is, the higher the cell proliferation rate is, and accordingly, it is possible to determine that the cell proliferation promotion titer of the added ingredients is larger. The results are shown in Fig. 2.

[0018] It is recognized from the aforementioned Experiment 1 that D-pantothenyl alcohol has a melanogenesis inhibitory action and is a material having a skin-whitening effect.

[0019] It is also recognized from the aforementioned experiment 2 that D-pantothenyl alcohol also has a keratinocyte cell proliferation action, and the keratinocyte cell proliferation is considered to promote turnover of keratinocytes and to promote melanin discharge.

[0020] It is recognized from the aforementioned experiments that D-pantothenyl alcohol not only inhibits melanogenesis but also promotes melanin discharge, and through the skin-whitening action by such two action mechanisms, D-pantothenyl alcohol achieves a high skin-whitening effect. Furthermore, having the two action mechanisms, particularly having the turnover promoting action of keratinocytes, can be expected to allow a faster skin-whitening effect to be obtained (faster skin-whitening rate) compared to conventional skin-whitening agents. In addition, having such action mechanisms different from those of conventional skin-whitening agents, with combined use of other skin-whitening agents, can be expected to allow a skin-whitening effect durability and a higher skin-whitening effect.

[0021] Thus, since D-pantothenyl alcohol achieves a high skin-whitening effect, it is preferably formulated into skin-whitening cosmetics. It is also preferably formulated as an effective ingredient into skin-whitening cosmetics. When D-pantothenyl alcohol is formulated into skin-whitening cosmetics, the amount of formulation is usually 0.0001% by mass or more, preferably 0.001% by mass or more, more preferably 0.01% by mass or more, still more preferably 0.1% by mass or more. Meanwhile, the upper limit is usually 20% by mass or less, preferably 10% by mass or less, more preferably 5% by mass or less.

[0022] An aspect of applying D-pantothenyl alcohol to the skin includes the use of a compound selected from Compounds 1-29 and / or a salt thereof for enhancing the skin-whitening effect of D-pantothenyl alcohol in a cosmetic composition. It should be noted that, unless otherwise specified, for compounds having optical isomers, any of the L form, the D form, and the racemate (DL form) is intended to be included in the present invention.

[0023] A salt, as used herein, refers to one which may be used without particular limitation as long as it is one which is used for skin external preparations. For example, sodium, alkali metal salts such as potassium, alkaline earth metal salts such as calcium and magnesium, ammonium salts, organic amine salts such as triethylamine and triethanolamine, and basic amino acid salts such as lysine and arginine are preferably exemplified. Among these salts, particularly preferred are alkali metals, and among others, sodium salts are particularly preferred.

[0024] Examples of compounds used according to the present invention include the following compounds 1 to 12.

[0025] Examples of compounds used according to the present invention also include the following compounds 13 to 22.

[0026] Examples of compounds used according to the present invention also include the following compounds 23 to 29.

[0027] A method in which a skin-whitening compound as shown above, or a salt thereof is applied in combination with D-pantothenyl alcohol to the skin for the purpose of a skin-whitening effect may be conducted as follows: When a skin-whitening compound as shown above and D-pantothenyl alcohol are applied to the skin, they are preferably applied simultaneously or nearly simultaneously. As used herein, "nearly simultaneously" refers to, for example, within one day, more preferably within 12 hours, more preferably within 6 hours, particularly preferably within 1 hour.

[0028] Specifically, preferable examples can include a method in which both are formulated in a skin external preparation and are applied to the skin as effective ingredients of the cosmetic preparation.

[0029] When a skin-whitening compound as shown above is formulated into a skin-whitening cosmetic, the amount of formulation is usually 0.0001% by mass or more, preferably 0.001% by mass or more, more preferably 0.01% by mass or more, still more preferably 0.1% by mass or more. Meanwhile, the upper limit is usually 20% by mass or less, preferably 10% by mass or less, more preferably 5% by mass or less.<Experiment 3: Confirmation of Synergistic Effect Based on Combination of either Plant Extract Having Melanogenesis Inhibitory Action (not according to the invention) or Existing Skin-whitening Compound and D-pantothenyl Alcohol>

[0030] In order to confirm the synergistic effect based on combining D-pantothenyl alcohol and the aforementioned plant extract having a melanogenesis inhibitory action and in order to confirm the synergistic effect based on combining D-pantothenyl alcohol and a skin-whitening compound, the experiment was conducted in the same manner as in the aforementioned <Experiment 1: Melanogenesis Inhibition Experiment> and <Experiment 2: Keratinocyte Cell Proliferation Experiment>. While 0 mM or 0 µM D-pantothenyl alcohol was used as a control similarly, the 1 mM D-pantothenyl alcohol in <Experiment 1> was replaced with each of the following samples (1) to (3) for experimenting. Sample (1): 1 mM D-pantothenyl alcohol Sample (2): one 1% species selected from the plant extracts listed Table 1 (extracts 1 to 50) (not according to the invention), or one 0.1 µg / mL species selected from existing skin-whitening compounds Sample (3): a combination of the sample (1) and each of the samples (2)

[0031] In addition, the 15 µM and the 150 µM D-pantothenyl alcohol in <Experiment 2> were replaced with the aforementioned samples (1) to (3) respectively for experimenting. The results are shown in Table 2. Note that the amount of melanin (%) and the cell proliferation rate (%) in Table 2 are both a ratio to the control, as described in Experiment 1 and Experiment 2.

[0032] As a note, the existing skin-whitening compounds used here are "4-n-butyl resorcinol" (not according to the invention), "ursolic acid phosphate ester" (not according to the invention), the aforementioned compounds 1, 31 (the latter not according to the invention), and 45 (not according to the invention).

[0033] In the present experiment, as the compound 1, 1-(triphenylmethyl) imidazole was synthesized by the method described in WO2010 / 074052 and was used. As the compound 31, N-benzoyl-L-serine was synthesized by the method described in WO2011 / 074643 and was used. As the compound 45, N-(toluyl) methionine was made by the method described in WO2010 / 058730 and was used. The below-mentioned <Skin-whitening Rate> is as above. Table 1No.Plant Extracts1Uncaria gambir extract2Isodon japonicus extract3Echinacea angustifolia leaf extract4Lithospermum erythrorhizon root extract5Carthamus tinctorius flower extract6Persea gratissima fruit extract7Abelmoschus esclentus fruit extract8Actinidia chinensis fruit extract9Alpinia speciosa leaf extract10Saponaria officinalis extract11Caprifoliaceae extract12green tea extract13Benincasa cerifera seed exract14Allium sativum extract15Citrus aurantifolia fruit juice extract16natto extract17Citrus aurantium dulsis fruit extract18Valeriana officinalis extract19Cucumis sativus extract20Prunus armeniaca extract21Gardenia florida extract22Citrus grandis fruit extract23Arctium lappa root extract24black tea extract25Equisetum arvense extract26Malva sylvestris extract27Jujube extract28Solanum lycopersicum extract29Daucus carota sativa extract30Hoelen extract31Lilium candidum bulb extract32Litchi chinensis extract33Lactuca scariola sativa leaf extract34Citrus medica limonum fruit extract35royal jelly extract36Pleurotus cornucopiae extract37Algae extract38Zanthoxylum bungeanum pericarp extract39Coprinus comatus extract40Salix alba bark extract41horsetail extract42Ampelopsis grossedentata leaf extract43Acer palmatum leaf extract44Opuntia streptacantha stem extract45Bidens pilosa extract46Prunus mume fruit water extract47Mallotus philippinensis bark extract48Salacia reticulata wood extract49Euphrasia officinalis extract50Nelumbo nucifera germ extract Table 2 (Plant extract 1-50, 4-n-butyl resorcinol, Ursolic acid phosphate ester, Compound 31 and Compound 45 are not according to the invention) Melanin Amount (%)Cell Proliferation Rate (%)Sample (1)Sample (2)Sample (3)Sample (1)Sample (2)Sample (3)Plant extract 169.896.261.2123.3103.2136.3Plant extract 269.895.862.1123.396.5130.6Plant extract 369.896.860.2123.3106.3126.2Plant extract 469.898.660.8123.3102.3128.6Plant extract 569.897.261.1123.3101.2130.1Plant extract 669.899.465.3123.3118.9129.3Plant extract 769.898.364.3123.3109.5128.1Plant extract 869.897.963.8123.3103.5130.3Plant extract 969.898.663.5123.391.2143.8Plant extract 1069.899.465.4123.3114.5128.4Plant extract 1169.898.664.4123.3105.7130.6Plant extract 1269.898.364.6123.3122.1166.2Plant extract 1369.899.565.3123.3117.0137.9Plant extract 1469.897.763.4123.3106.0128.4Plant extract 1569.898.464.3123.398.4136.3Plant extract 1669.898.965.1123.3106.0142.0Plant extract 1769.897.864.1123.3109.5128.4Plant extract 1869.897.764.0123.393.5130.3Plant extract 1969.899.365.5123.3112.2129.6Plant extract 2069.898.264.1123.3115.9130.0Plant extract 2169.898.664.7123.3111.3133.0Plant extract 2269.899.465.4123.3112.2131.9Plant extract 2369.898.364.0123.393.1128.9Plant extract 2469.897.863.7123.394.7130.9Plant extract 2569.898.564.6123.3114.1132.1Plant extract 2669.899.165.0123.3117.3131.4Plant extract 2769.899.064.8123.3114.8136.5Plant extract 2869.898.764.6123.3115.0128.6Plant extract 2969.898.364.3123.3112.2129.6Plant extract 3069.899.265.0123.3119.2134.9Plant extract 3169.897.663.6123.3106.5137.2Plant extract 3269.898.664.5123.3120.8143.9Plant extract 3369.898.864.6123.3104.8132.8Plant extract 3469.899.865.8123.3116.4136.0Plant extract 3569.898.664.9123.3117.8137.2Plant extract 3669.899.869.7123.3101.5129.8Plant extract 3769.897.669.7123.3102.4129.9Plant extract 3869.899.169.4123.3102.8130.1Plant extract 3969.899.569.6123.3102.3129.8Plant extract 4069.898.769.7123.3100.2130.3Plant extract 4169.898.865.0123.3101.3123.2Plant extract 4269.898.364.3123.3102.3123.1Plant extract 4369.898.664.8123.3105.3123.3Plant extract 4469.898.964.1123.3100.8122.9Plant extract 4569.898.864.5123.399.9123.5Plant extract 4669.899.869.9123.399.8123.3Plant extract 4769.898.669.8123.3100.9123.4Plant extract 4869.899.169.8123.3101.6123.3Plant extract 4969.898.669.7123.3102.7123.0Plant extract 5069.899.369.8123.3100.6123.14-n-butyl resorcinol69.893.259.4123.3120.3140.7Ursolic acid phosphate ester69.898.461.0123.3118.6139.8Compound 169.893.159.1123.3112.1139.7Compound 3169.894.660.1123.3118.7139.8Compound 4569.893.459.8123.3113.2140.2

[0034] It is recognized from the above results that the synergistic effect of a melanogenesis inhibitory action and a keratinocyte cell proliferation action is obtained by applying the plant extracts 1 to 35, the compounds 1, 31, or 45, 4-n-butyl resorcinol, or an ursolic acid phosphate ester, in combination with D-pantothenyl alcohol. It is also recognized that the synergistic effect of a keratinocyte cell proliferation action is obtained by applying D-pantothenyl alcohol and the plant extracts 36 to 40 in combination and that the synergistic effect of a melanogenesis inhibition is obtained by applying D-pantothenyl alcohol and the plant extracts 41 to 45 in combination.

[0035] Above all, when the synergistic effect is achieved for a melanogenesis inhibitory action and a keratinocyte cell proliferation action, it is considered that the turnover promoting function, i.e., the melanin discharge promoting function, of D-pantothenyl alcohol was able to be further enhanced, and the skin-whitening rate for pigmented skin can be expected to be further accelerated.

[0036] In the preparation of skin-whitening cosmetics with D-pantothenyl alcohol formulated thereinto, the cosmetics can contain an ingredient used in ordinary cosmetics. In addition, their dosage forms are not limited in any way. Below, ingredients which can be contained in skin-whitening cosmetics when applied to skin-whitening cosmetics will be described.

[0037] Examples of effective ingredients include further skin-whitening ingredients other than D-pantothenyl alcohol or Compounds 1-29, anti-wrinkle ingredients, anti-inflammatory ingredients other than pantothenyl alcohol and extracts derived from plants and animals. When D-pantothenyl alcohol is used as an effective ingredient, two or more effective ingredients may be contained.

[0038] The further skin-whitening ingredients are not particularly limited as long as they are generally used for cosmetics. Examples include 4-n-butyl resorcinol, ascorbic acid glucoside, 3-O-ethyl ascorbic acid, tranexamic acid, arbutin, 1-triphenylmethylpiperidine, 1-triphenylmethylpyrrolidine, 2-(triphenylmethyloxy)ethanol, 2-(triphenylmethylamino)ethanol, 2-(triphenylmethyloxy)ethylamine, triphenylmethylamine, triphenylmethanol, triphenylmethane, and aminodiphenylmethane, N-(p-toluyl)cysteic acid and N-(p-methoxybenzoyl)cysteic acid. Still other skin-whitening ingredients include N-benzoyl-serine, N-(p-methylbenzoyl)serine, N-(p-ethylbenzoyl)serine, N-(p-methoxybenzoyl) serine, N-(p-fluorobenzoyl)serine, N-(p-trifluoromethylbenzoyl) serine, N-(2-naphthoyl) serine, N-(4-phenylbenzoyl) serine, N-(p-methylbenzoyl)serine methyl ester, N-(p-methylbenzoyl)serine ethyl ester, N-(2-naphthoyl)serine methyl ester, N-benzoyl-O-methylserine, N-(p-methylbenzoyl)-O-methylserine, N-(p-methylbenzoyl)-O-acetyl serine and N-(2-naphthoyl)-O-methylserine.

[0039] These further skin-whitening ingredients can be already commercially available or can also be obtained synthetically.

[0040] The content of skin-whitening ingredients in skin-whitening cosmetics is usually 0.01 to 30 % by mass, preferably 0.1 to 10 % by mass, more preferably 1 to 5% by mass.

[0041] The anti-wrinkle ingredients are not particularly limited as long as they are generally used for cosmetics. Examples include vitamin A or a derivative thereof, retinol, retinal, retinoic acid, tretinoin, isotretinoin, tocopherol retinoate, retinol palmitate, retinol acetate, benzyl ursolate ester, ursolic acid phosphate ester, benzyl betulinate ester, and benzilic acid phosphate ester. The content of the anti-wrinkle ingredients in cosmetics is usually 0.01 to 30 % by mass, preferably 0.1 to 10 % by mass, more preferably 1 to 5% by mass.

[0042] The extracts derived from plants and animals are not particularly limited as long as they are generally used for pharmaceuticals, cosmetics or food. Examples of preferable extracts include Akebia quinata extract, Thujopsis dolabrata branch extract, Asparagus officinalis extract, Persea gratissima fruit extract, Hydrangea serrata leaf extract, Prunus amygdalus dulcis seed extract, Arnica extract, Aloe extract, Aronia extract, Prunus armeniaca extract, Ginkgo biloba extract, Indian kino extract, Foeniculum vulgare fruit extract, Aralia cordata extract, Rosa multiflora fruit extract, Acanthopanax senticosus extract, Isodonis japonicus extract, Scutellaria root extract, Phellodendron amurense extract, Coptis extract, Panax ginseng extract, Hypericum erectum extract, Lamium album extract, Citrus aurantium dulsis fruit extract, Pyracantha fortuneana extract, Pueraria lobata root extract, Chamomilla extract, Daucus carota sativa extract, Artemisia capillaris extract, Hemerocallis fulva extract, Actinidia chinensis fruit extract, Cucumis sativus extract, Psidium guajava extract, Sophora root extract, Gardenia florida extract, Sasa veitchii leaf extract, Sophora flavescens extract, Juglans extract, Citrus grandis fruit extract, black rice extract, Chlorella vulgaris extract, Morus alba extract, Mucuna birdwoodiana stem extract, Alpinia speciosa leaf extract, Gentiana lutea extract, Geranium thunbergii extract, black tea extract, Arctium lappa root extract, Oryza sativa extract, Rice ferment extract, Rice bran ferment extract, Oryza sativa germ oil, Vaccinium vitis-idaea extract, Salvia sclarea extract, Saponaria officinalis extract, Sasa extract, Crataegus cuneata fruit extract, Coriandrum sativum fruit extract, Zanthoxylum piperitum extract, Lentinus edodes extract, Rehmannia root extract, Lithospermum erythrorhizon root extract, Perilla extract, Tilia japonica extract, Spiraea ulmaria flower extract, Paeonia albiflora extract, Zingiber officinale root extract, Acorus calamus root extract, Betula alba extract, Equisetum arvense extract, Stevia rebaudiana extract, Stevia fermented product, Hedera helix extract, Crataegus oxyacantha extract, Sambucus nigra extract, Achillea milefolium extract, Mentha piperita extract, Salvia officinalis extract, Malva sylvestris extract, Cnidium officinale extract, Swertia japonica extract, Morus alba root extract, Rheum extract, Glycine soja extract, Jujube extract, Thymus vulgaris extract, Taraxacum extract, tea extract, Eugenia caryophyllus flower extract, Rutaceae extract, sweet tea extract, Capsicum annuum extract, Angelica acutiloba extract, Calendula officinalis extract, Prunus persica extract, Citrus aurantium extract, Houttuynia cordata extract, Solanum lycopersicum extract, natto extract, Daucus carota sativa extract, Allium sativum extract, Rosa canina fruit extract, Hibiscus sabdariffa flower extract, Ophiopogon japonicus extract, Nelumbo nucifera extract, Carum petroselinum extract, birch extract, Hamamelis virginiana extract, Isodon japonicus extract, Cupressaceae extract, Eriobotrya japonica extract, Tussilago farfara extract, butterbur sprout extract, Hoelen extract, Ruscus aculeatus root extract, Vitis vinifera fruit extract, Vitis vinifera seed extract, Luffa cylindrica extract, Carthamus tinctorius flower extract, Mentha piperita extract, Tilia platyphyllos flower extract, Paeonia suffruticosa root extract, Humulus lupulus extract, Pinus sylvestris cone extract, Origanum majorana leaf extract, Aesculus hippocastanum extract, Lysichiton extract, Sapindus mukorossi peel extract, Melissa officinalis extract, Spermatochnaceae extract, Prunus persica extract, Centaurea cyanus flower extract, Eucalyptus globulus extract, Saxifraga sarmentosa extract, Citrus junos fruit extract, Lilium candidum bulb extract, coix seed extract, Artemisia extract, Lavandula angustifolia extract, green tea extract, Pyrus malus fruit extract, rooibos tea extract, Litchi chinensis extract, Lactuca scariola sativa leaf extract, Citrus medica limonum fruit extract, Forsythia extract, Astragalus sinicus extract, rose extract, Rosmarinus officinalis extract, Anthemis nobilis flower extract, royal jelly extract, and Sanguisorba officinalis root extract.

[0043] The content of the extracts derived from plants and animals in cosmetics is usually 0.01 to 30 % by mass, preferably 0.1 to 10 % by mass, more preferably 1 to 5% by mass.

[0044] Examples of anti-inflammatory ingredients include Kurarinone, glabridin, glycyrrhizic acid and glycyrrhetinic acid, and are preferably, glycyrrhizic acid and a salt thereof, glycyrrhetinic acid alkyl and a salt thereof, as well as glycyrrhetinic acid and a salt thereof.

[0045] The content of the anti-inflammatory ingredients in cosmetics is usually 0.01 to 30 % by mass, preferably 0.1 to 10 % by mass, more preferably 1 to 5% by mass.

[0046] Examples of oily ingredients include polar oils and volatile hydrocarbon oils.

[0047] Examples of polar oils include, as synthetic ester oils, isopropyl myristate, cetyl octanoate, octyldodecyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, decyl oleate, hexyl decyl dimethyl-octanoate, cetyl lactate, myristyl lactate, lanolin acetate, isocetyl stearate, isocetyl isostearate, cholesteryl 12-hydroxystearate, ethylene glycol di-2-ethylhexylate, dipentaerythritol fatty acid ester, N-alkyl glycol monoisostearate, neopentyl glycol dicaprate, diisostearyl malate, glycerin di-2-heptylundecanoate, trimethylol propane tri-2-ethylhexylate, trimethylolpropane triisostearate, pentane erythritol tetra-2-ethylhexylate, glycerin tri-2-ethylhexylate, and trimethylolpropane triisostearate.

[0048] Additional examples include cetyl 2-ethylhexanoate, 2-ethylhexyl palmitate, glycerin trimyristate, glyceride tri-2-heptylundecanoate, castor oil fatty acid methyl ester, oil oleate, cetostearyl alcohol, acetone glyceride, 2-heptylundecyl palmitate, diisobutyl adipate, 2-octyldodecyl N-lauroyl-L-glutamate ester, di-2-heptylundecyl adipate, ethyl laurate, di-2-ethylhexyl sebacate, 2-hexyldecyl myristate, 2-hexyldecyl palmitate, 2-hexyldecyl adipate, diisopropyl sebacate, 2-ethylhexyl succinate, ethyl acetate, butyl acetate, amyl acetate, triethyl citrate and octyl methoxycinnamate.

[0049] Examples of natural oils include avocado oil, camellia oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, persic oil, wheat germ oil, sasanqua oil, castor oil, linseed oil, safflower oil, cottonseed oil, perilla oil, soybean oil, peanut oil, tea seed oil, kaya oil, rice bran oil, Chinese tung oil, Japanese tung oil, jojoba oil, germ oil, triglycerol, glycerin trioctanoate and glycerin triisopalmitate.

[0050] Examples of volatile hydrocarbon oils include isododecane and isohexadecane.

[0051] Examples of surfactants include anionic surfactants such as fatty acid soap (sodium laurate, sodium palmitate, etc.), potassium laurylsulfate, and triethanolamine alkylsulfate ether, and cationic surfactants such as stearyl trimethyl ammonium chloride, benzalkonium chloride, and lauryl amine oxide; amphoteric surfactants such as betaine-based surfactants (alkyl betaine, amido betaine, sulfobetaine, etc.), imidazoline-based amphoteric surfactants (2-cocoyl-2-imidazolinium hydroxide-1-carboxyethyloxy disodium salt etc.), and acyl methyl taurine; and non-ionic surfactants such as sorbitan fatty acid esters (sorbitan monostearate, sorbitan sesquioleate, etc.), glycerin fatty acids (glycerin monostearate etc.), propylene glycol fatty acid esters (propylene glycol monostearate etc.), hydrogenated castor oil derivatives, glycerin alkyl ethers, POE sorbitan fatty acid esters (POE sorbitan monooleate, polyoxyethylene sorbitan monostearate, etc.), POE sorbitol fatty acid esters (POE-sorbit monolaurate etc.), POE glycerine fatty acid esters (POE-glycerine monoisostearate, etc.), POE fatty acid esters (polyethylene glycol monooleate, POE distearate, etc.), POE alkyl ethers (POE2-octyldodecyl ether etc.), POE alkylphenyl ethers (POE nonylphenyl ether etc.), Pluronic type ethers, POE / POP alkyl ethers (POE / POP2-decyltetradecyl ether etc.), Tetronic ethers, POE castor oil / hydrogenated castor oil derivatives (POE castor oil, POE hydrogenated castor oil, etc.), sucrose fatty acid esters, and alkyl glucosides

[0052] Examples of polyhydric alcohols include polyethylene glycol, glycerine, 1,3-butylene glycol, erythritol, sorbitol, xylitol, maltitol, propylene glycol, dipropylene glycol, diglycerine, isoprene glycol, 1,2-pentanediol, 2,4-hexylene glycol, 1,2-hexanediol and 1,2-octanediol.

[0053] Examples of thickeners include guar gum, quince seed, carrageenan, galactan, gum arabic, pectin, mannan, starch, xanthan gum, curdlan, methyl cellulose, hydroxyethyl cellulose, carboxymethyl cellulose, methyl hydroxypropyl cellulose, chondroitin sulfate, dermatan sulfate, glycogen, sodium heparan sulfate, hyaluronic acid, sodium hyaluronate, tragacanth, keratan sulfate, chondroitin, mucoitin sulfate, hydroxyethyl guar gum, carboxymethyl guar gum, dextran, keratosulfate sulfate, locust bean gum, succinoglucan, charonic acid, chitin, chitosan, carboxymethyl chitin, agar, polyvinyl alcohol, polyvinyl pyrrolidone, carboxyvinyl polymers, alkyl-modified carboxyvinyl polymers, sodium polyacrylate, polyethylene glycol, and bentonite.

[0054] Examples of powders include powder which may be surface-treated, such as mica, talc, kaolin, synthetic mica, calcium carbonate, magnesium carbonate, silicic anhydride (silica), aluminum oxide, and barium sulfate; inorganic pigments which may be surface-treated, such as red iron oxide, yellow iron oxide, black iron oxide, cobalt oxide, ultramarine, iron blue, titanium oxide, and zinc oxide; pearl agents which may be surface-treated such as mica titanium, fish scale guanine, and bismuth oxychloride; organic dyes which may be laked, such as Red No. 202, Red No. 228, Red No. 226, Yellow No. 4, Blue No. 404, Yellow No. 5, Red No. 505, Red No. 230, Red No. 223, Orange No. 201, Red No. 213, Yellow No. 204, Yellow No. 203, Blue No. 1, Green No. 201, Purple No. 201, and Red No. 204; and organic powders such as polyethylene powder, methyl polymethacrylate, nylon powder, and organopolysiloxane elastomer.

[0055] Examples of ultraviolet absorbers include para-aminobenzoic acid-based ultraviolet absorbers, anthranilic acid-based ultraviolet absorbers, salicylic acid-based ultraviolet absorbers, cinnamic acid-based ultraviolet absorbers, benzophenone ultraviolet absorbers, sugar-based ultraviolet absorbers, and ultraviolet absorbers such as 2-(2'-hydroxy-5'-t-octylphenyl)benzotriazole and 4-methoxy-4'-t-butyldibenzoyl methane.

[0056] Skin-whitening cosmetics, without a manufacturing method therefor being particularly limited, can be manufactured using a known method as appropriate, in accordance with the dosage form to be applied of skin-whitening cosmetics. The dosage form, as applied as a skin-whitening cosmetic, can take any of a lotion dosage form, emulsion dosage form, essence dosage form, cream dosage form, and powder-containing dosage form which are normally known.Examples

[0057] Below, the present invention will be described in further detail with reference to specific experimental examples, but the present invention is not limited to the following aspects only.<Examples 1 to 4> (not according to the invention)

[0058] The skin-whitening cosmetics 1 to 4 formulated as shown in the following Tables 3 to 6 were prepared. Table 3: Example 1 (lotion) (parts by (not according to the invention) mass)(A)D-pantothenyl alcohol1.0Glycerin5.0propylene glycol4.0Artemisia extract0.1Origanum majorana leaf extract0.1purified waterbalance(B)POE(20) sorbitan monolaurate ester1.5POE(20) lauryl ether0.5Ethanol10.0Perfume0.1Total100.0(Preparation Method) The ingredients of (A) were combined and dissolved at room temperature. The ingredients of (B) were also dissolved at room temperature, added to the formulation (A), and solubilized, to obtain the skin-whitening cosmetic 1. Table 4: Example 2 (emulsion) (parts by (not according to the invention) mass) (A)POE(20) hydrogenated castor oil1.5coconut oil fatty acid monoglyceride1.0oleic acid triglyceride7.5(B)D-pantothenyl alcohol1.0glycerin2.5Artemisia extract0.1Origanum majorana leaf extract0.1purified waterbalance(C)perfume0.2Total100.0 (Preparation Method) The ingredients of (A) were combined and mixed / heated to 70°C. The ingredients of (B) were combined and mixed / heated to 70°C, the formulation (A) was added thereto and emulsified, and (C) was added under cooling, to obtain the skin-whitening cosmetic 2. Table 5: Example 3 (hand cream) (parts by (not according to the invention) mass) (A)petrolatum18.0cetanol8.0POE(20) oleyl ether1.4sorbitan monostearate0.8(B)D-pantothenyl alcohol1.0preservative0.3Artemisia extract0.1Origanum majorana leaf extract0.1purified waterbalance ©< perfume0.2Total100.0 (Preparation Method) The skin-whitening cosmetic 3 was obtained in the same manner as in Example 2. Table 6: Example 4 (cream) (parts by (not according to the invention) mass) (A)POE(30) cetyl ether2.0glycerin monostearate10.0liquid paraffin10.0petrolatum4.0cetanol5.0preservative0.2(B)D-pantothenyl alcohol1.0propylene glycol10.0Artemisia extract0.1Origanum majorana leaf extract0.1purified waterbalanceTotal100.0 (Preparation Method) The ingredients of (A) were combined and heated to 80°C. The ingredients of (B) were combined and heated to 80°C. The mixture of (B) was added to the mixture of (A) under stirring, emulsified under stirring, and then cooled, to obtain the skin-whitening cosmetic 4. <Evaluation of Skin-whitening>

[0059] The comparative cosmetics 1 to 3 were made in the same manner as the method described in Example 1 except that the "D-pantothenyl alcohol" in Example 1 was replaced with "water", replaced with an existing skin-whitening ingredient, "2-hydroxy-2'-hydroxy-5,5'-dipropyl-1,1'-biphenyl", having a formulation concentration of 1%, and replaced with "disodium adenosine monophosphate" having a formulation concentration of 2%, for the comparative cosmetics 1 to 3 respectively. The skin-whitening cosmetic 1 and the comparative cosmetics 1 to 3 were evaluated for pigmentation inhibitory action in accordance with the following procedure.

[0060] A total of four 1.5 cm × 1.5 cm sites were provided inside an upper arm of a panelist who voluntarily participated. The provided sites were subjected to a minimal erythema dose (1MED) of ultraviolet irradiation once a day, three times for three consecutive days. The skin-whitening cosmetic 1 and the comparative cosmetics 1 to 3 were applied at 50 µL twice a day for 21 consecutive days after completion of the ultraviolet irradiation in Experiment Day 1 (after completion of the first irradiation). Twenty-four hours after completion of the application in Day 21, each test site was measured for skin brightness (L* value) with a color difference meter (CR-300, Konica Minolta Inc.), and the difference between the L* value of the applied site of the comparative cosmetic 1 (control) and the L* value of the applied site of the skin-whitening cosmetic 1 or the comparative cosmetic 2 or 3 was calculated (ΔL* value = L* value of the applied site of the skin-whitening cosmetic 1 (or the comparative cosmetic 2 or 3) - L* value of the applied site of the comparative cosmetic 1). The greater the degree of pigmentation is, the lower the L* value is. Accordingly, it is possible to determine that the larger the ΔL* value is, the more improved the pigmentation has been. The calculated ΔL* value of 0.4 or more was determined to be A, and less than 0.4 to be B. The results are shown in Table 7. Table 7Formulation Concentration (% by mass)L* valueΔL* valueDeterminationSkin-whitening cosmetic 1 (not according to the invention)1%63.920.40AComparative cosmetic 21%63.820.30BComparative cosmetic 32%63.850.33BComparative cosmetic 1 (Control)-63.52--

[0061] According to the results in Table 7, the skin-whitening cosmetic 1 has a strong pigmentation inhibitory action, compared with the comparative cosmetic 2 and the comparative cosmetic 3, and this shows that the skin-whitening cosmetic 1 exhibits an excellent skin-whitening effect (pigmentation improving effect). This is a skin-whitening effect by the melanogenesis inhibitor (D-pantothenyl alcohol) contained in the skin-whitening cosmetic 1. It can also be appreciated that since the melanogenesis inhibitor also has a keratinocyte cell proliferation action in addition to the melanogenesis inhibitory action, it can achieve a higher skin-whitening effect compared with existing skin-whitening agents.<Reference Examples 1 to 64 (Skin-whitening Cosmetics 5 to 68)>

[0062] The skin-whitening cosmetic 5 formulated as shown in Table 8 below was prepared. In addition, the skin-whitening cosmetics 5 to 55 further containing in the formulation (A) the plant extracts shown in Table 1 (not according to the invention) at a concentration of 1.0% by mass relative to the total amount of the cosmetic were prepared. In addition, the plant extracts were replaced with "4-n-butyl resorcinol" (not according to the invention), "ursolic acid phosphate ester" (not according to the invention), "2-hydroxy-2'-hydroxy-5,5'-dipropyl-1,1'-biphenyl" (not according to the invention), "disodium adenosine monophosphate" (not according to the invention), the aforementioned compounds 1, 2, 13, 30, 31, 33, 45, 47, or 49, (compounds 30, 31, 33, 45, 47, and 49 are not according to the invention) to prepare the skin-whitening cosmetics 56 to 68. The concentrations of the "4-n-butyl resorcinol", "ursolic acid phosphate ester", compounds 1, 2, 13, 30, 31, 33, 45, 47, and 49 were 0.1% by mass relative to the total amount of the cosmetic, and the concentrations of the "2-hydroxy-2'-hydroxy-5,5'-dipropyl-1,1'-biphenyl", and "disodium adenosine monophosphate" were 1.0% by mass relative to the total amount of the cosmetic.

[0063] As a note, in the present experiment, 1-(triphenylmethyl)piperidine was synthesized by the method described in WO2010 / 074052 and was used for the compound 2, and 2-(triphenylmethyloxy)ethanol was synthesized by the method described in the same literature and was used for the compound 13. N-(pmethylbenzoyl)-L-serine was synthesized by the method described in WO2011 / 074643 and was used for the compound 30, and N-(p-methoxybenzoyl)-L-serine was synthesized by the method described in the same literature and was used for the compound 33. N-(toluyl)cysteic acid was synthesized by the method described in WO2010 / 058730 and was used for the compound 47, and N-(4-methoxybenzoyl)-L-cysteic acid was synthesized by the method described in the same literature and was used for the compound 49. The compounds 1, 31, and 45 are the same as in the aforementioned <Experiment 3>.

[0064] Any of the skin-whitening cosmetics 5 to 68 was obtained by the same preparation method as the cosmetic 1, in which the ingredients of (A) were combined and dissolved at room temperature, and the ingredients of (B) were dissolved at room temperature, added to the formulation (A), and solubilized. Table 8: Skin-whitening Cosmetic 5 (parts by (lotion) (not according to the mass) invention)(A)D-pantothenyl alcohol1.0glycerin5.0propylene glycol4.0purified waterbalance(B)POE(20) sorbitan monolaurate ester1.5POE(20) lauryl ether0.5ethanol10.0perfume0.1Total100.0 <Evaluation of Skin-Whitening Rate>

[0065] The aforementioned skin-whitening cosmetics 5 to 68 were evaluated for skin-whitening rate in accordance with the following procedure. The comparative cosmetic 4 was prepared in the same manner as the cosmetic 5 except that the D-pantothenyl alcohol formulated into the cosmetic 5 was replaced with water.

[0066] A total of eight 1.0 cm × 1.0 cm sites were provided inside the right and left upper arms of a panelist who voluntarily participated. The provided sites were subjected to a minimal erythema dose (1MED) of ultraviolet irradiation once a day, three times for three consecutive days. The skin-whitening cosmetics 5 to 68 and the comparative cosmetic 4 were applied at 50 µL twice a day for 21 consecutive days after completion of the ultraviolet irradiation in Experiment Day 1 (after completion of the first irradiation). Twenty-four hours after completion of the second application of each day, each test site was measured for skin brightness (L* value) with a color difference meter (CR-300, Konica Minolta Inc.), and the difference between the L* value of the applied site of the comparative cosmetic 4 and the L* value of the applied site of the skin-whitening cosmetics 5 to 68 was calculated (ΔL* value = L* value of the applied site of the skin-whitening cosmetic 5 (or the skin-whitening cosmetics 6 to 68) - L* value of the applied site of the comparative cosmetic 4). The greater the degree of pigmentation is, the lower the L* value is. Accordingly, it is possible to determine that the larger the ΔL* value is, the more improved the pigmentation has been. The number of days taken for the calculated ΔL* value to become 0.4 and the ΔL* value measured / calculated 24 hours after completion of the application in Day 21 are shown in Tables 9 to 19.

[0067] Furthermore, the cosmetics 6' to 68' each were prepared in the same manner as the cosmetic 5 except that the D-pantothenyl alcohol formulated into the cosmetics 6 to 68 was replaced with water, in order to calculate the ΔL* value and the number of days taken for the ΔL* value to become 0.4 for the cosmetics 6 to 68 containing none of the skin-whitening ingredient D pantothenyl alcohol, i.e., containing only any of the aforementioned plant extract or an existing skin-whitening compound as a skin-whitening ingredient. Subsequently, in the same manner as in the aforementioned <Evaluation of Skin-whitening Rate>, the comparative cosmetic 4 was used as a control, and the number of days taken for the ΔL* value to become 0.4 as well as the L* value and ΔL* value measured 24 hours after completion of the application in Day 21 was obtained. The ΔL* values measured / calculated 24 hours after completion of the application in Day 21 are shown as "ΔL* value for no D-pantothenyl alcohol" in Tables 9 to 19. The number of days taken for the ΔL* value to become 0.4 was more than 21 days in every case. Table 9 (skin-whitening cosmetics 5-11 are not according to the invention)Skin-whitening CosmeticSkin-whitening IngredientΔL* ValueNo. of Days Taken for ΔL* Value = 0.4ΔL* Value for No D-pantothenyl Alcohol5D-pantothenyl alcohol0.4121-6D-pantothenyl alcohol + plant extract 10.44180.107D-pantothenyl alcohol + plant extract 20.43190.088D-pantothenyl alcohol + plant extract 30.44180.119D-pantothenyl alcohol + plant extract 40.44190.1210D-pantothenyl alcohol + plant extract 50.43200.1111D-pantothenyl alcohol + plant extract 60.42200.08Comparative cosmetic 4 (Control)---- Table 10 (skin-whitening cosmetics 5 and 12-17 are not according to the invention) Skin-whitening CosmeticSkin-whitening IngredientΔL* ValueNo. of Days Taken for ΔL* Value = 0.4ΔL* Value for No D-pantothenyl Alcohol5D-pantothenyl alcohol0.4021-12D-pantothenyl alcohol + plant extract 70.41200.0713D-pantothenyl alcohol + plant extract 80.41200.0714D-pantothenyl alcohol + plant extract 90.41200.0815D-pantothenyl alcohol + plant extract 100.41200.0916D-pantothenyl alcohol + plant extract 110.41200.0817D-pantothenyl alcohol + plant extract 120.41200.10Comparative cosmetic 4 (Control)---- Table 11 (skin-whitening cosmetics 5 and 18-23 are not according to the invention) Skin-whitening CosmeticSkin-whitening IngredientΔL* ValueNo. of Days Taken for ΔL* Value = 0.4ΔL* Value for No D-pantothenyl Alcohol5D-pantothenyl alcohol0.4021-18D-pantothenyl alcohol + plant extract 130.41200.0819D-pantothenyl alcohol + plant extract 140.41200.0820D-pantothenyl alcohol + plant extract 150.41200.0721D-pantothenyl alcohol + plant extract 160.41200.0822D-pantothenyl alcohol + plant extract 170.41200.0823D-pantothenyl alcohol + plant extract 180.41200.07Comparative cosmetic 4 (Control)---- Table 12 (skin-whitening cosmetics 5 and 24-29 are not according to the invention) Skin-whitening CosmeticSkin-whitening IngredientΔL* ValueNo. of Days Taken for ΔL* Value = 0.4ΔL* Value for No D-pantothenyl Alcohol5D-pantothenyl alcohol0.4121-24D-pantothenyl alcohol + plant extract 190.42200.0925D-pantothenyl alcohol + plant extract 200.42200.0726D-pantothenyl alcohol + plant extract 210.42200.0827D-pantothenyl alcohol + plant extract 220.42200.0828D-pantothenyl alcohol + plant extract 230.42200.0929D-pantothenyl alcohol + plant extract 240.42200.07Comparative cosmetic 4 (Control)---- Table 13 (skin-whitening cosmetics 5 and 30-35 are not according to the invention) Skin-whitening CosmeticSkin-whitening IngredientΔL* ValueNo. of Days Taken for ΔL* Value = 0.4ΔL* Value for No D-pantothenyl Alcohol5D-pantothenyl alcohol0.4021-30D-pantothenyl alcohol + plant extract 250.41200.0831D-pantothenyl alcohol + plant extract 260.41200.0932D-pantothenyl alcohol + plant extract 270.41200.0733D-pantothenyl alcohol + plant extract 280.41200.0834D-pantothenyl alcohol + plant extract 290.41200.0935D-pantothenyl alcohol + plant extract 300.41200.07Comparative cosmetic 4 (Control)---- Table 14 (skin-whitening cosmetics 5 and 36-41 are not according to the invention) Skin-whitening CosmeticSkin-whitening IngredientΔL* ValueNo. of Days Taken for ΔL* Value = 0.4ΔL* Value for No D-pantothenyl Alcohol5D-pantothenyl alcohol0.4021-36D-pantothenyl alcohol + plant extract 310.41200.0837D-pantothenyl alcohol + plant extract 320.41200.1038D-pantothenyl alcohol + plant extract 330.41200.0939D-pantothenyl alcohol + plant extract 340.41200.0840D-pantothenyl alcohol + plant extract 350.41200.0841D-pantothenyl alcohol + plant extract 360.40210.10Comparative cosmetic 4 (Control)---- Table 15 (skin-whitening cosmetics 5 and 42-47 are not according to the invention) Skin-whitening CosmeticSkin-whitening IngredientΔL* ValueNo. of Days Taken for ΔL* Value = 0.4ΔL* Value for No D-pantothenyl Alcohol5D-pantothenyl alcohol0.4021-42D-pantothenyl alcohol + plant extract 370.40210.0943D-pantothenyl alcohol + plant extract 380.40210.0744D-pantothenyl alcohol + plant extract 390.40210.0845D-pantothenyl alcohol + plant extract 400.40210.0946D-pantothenyl alcohol + plant extract 410.40210.0847D-pantothenyl alcohol + plant extract 420.40210.08Comparative cosmetic 4 (Control)---- Table 16 (skin-whitening cosmetics 5 and 48-53 are not according to the invention) Skin-whitening CosmeticSkin-whitening IngredientΔL* ValueNo. of Days Taken for ΔL* Value = 0.4ΔL* Value for No D-pantothenyl Alcohol5D-pantothenyl alcohol0.4021-48D-pantothenyl alcohol + plant extract 430.40210.1049D-pantothenyl alcohol + plant extract 440.40210.0850D-pantothenyl alcohol + plant extract 450.40210.0551D-pantothenyl alcohol + plant extract 460.40210.1052D-pantothenyl alcohol + plant extract 470.40210.1053D-pantothenyl alcohol + plant extract 480.40210.06Comparative cosmetic 4 (Control)---- Table 17 (skin-whitening cosmetics 5 and 54-59 are not according to the invention) Skin-whitening CosmeticSkin-whitening IngredientΔL* ValueNo. of Days Taken for ΔL* Value = 0.4ΔL* Value for No D-pantothenyl Alcohol5D-pantothenyl alcohol0.4021-54D-pantothenyl alcohol + plant extract 490.40210.0555D-pantothenyl alcohol + plant extract 500.40210.1056D-pantothenyl alcohol + 4-n-butyl resorcinol0.43180.3557D-pantothenyl alcohol + ursolic acid phosphate ester0.43190.2058D-pantothenyl alcohol + 2-hydroxy-2'-hydroxy-5,5'-dipropyl-1,1'-biphenyl0.38210.2959D-pantothenyl alcohol + disodium adenosine monophosphate0.38210.33Comparative cosmetic 4 (Control)---- Table 18 (skin-whitening cosmetics 5 and 63-65 are not according to the invention) Skin-whitening CosmeticSkin-whitening IngredientΔL* ValueNo. of Days Taken for ΔL* Value = 0.4ΔL* Value for No D-pantothenyl Alcohol5D-pantothenyl alcohol0.4121-60D-pantothenyl alcohol + Compound 10.44180.3561D-pantothenyl alcohol + Compound 20.46170.3862D-pantothenyl alcohol + Compound 130.44180.3563D-pantothenyl alcohol + Compound 300.45180.3564D-pantothenyl alcohol + Compound 310.43180.3465D-pantothenyl alcohol + Compound 330.44180.34Comparative cosmetic 4 (Control)---- Table 19 (skin-whitening cosmetics 5 and 66-68 are not according to the invention) Skin-whitening CosmeticSkin-whitening IngredientΔL* ValueNo. of Days Taken for ΔL* Value = 0.4ΔL* Value for No D-pantothenyl Alcohol5D-pantothenyl alcohol0.4021-66D-pantothenyl alcohol + Compound 450.43180.3467D-pantothenyl alcohol + Compound 470.46170.3868D-pantothenyl alcohol + Compound 490.44180.34Comparative cosmetic 4 (Control)----

[0068] From the results in Tables 9 to 19, it can be appreciated that a skin-whitening effect is obtained more quickly by applying to the skin a combination of D-pantothenyl alcohol and a specific plant extract or a specific existing skin-whitening compound. This is considered to be because D-pantothenyl alcohol has a skin-whitening action based on the two action mechanisms of inhibiting melanogenesis and promoting melanin discharge as well.

Claims

1. Use of a compound selected from the following compounds 1 to 29 and / or a salt thereof for enhancing the skin-whitening effect of D-pantothenyl alcohol in a cosmetic composition: