Fibers made of polymers with a backbone containing a positively charged component of a hermaphroditic unit
Patent Information
- Application Number
- DE602020064450
- Authority / Receiving Office
- DE · DE
- Patent Type
- Patents
- Current Assignee / Owner
- Priority Date
- 2019-04-30
- Filing Date
- 2020-04-30
- Publication Date
- 2025-12-24
- Estimated Expiration
- 2040-04-30
AI Technical Summary
Current encapsulation devices for islet transplantation in Type 1 diabetes suffer from mechanical weakness, limited mass delivery, and fibrotic growth, posing safety concerns and hindering long-term functionality and retrieval.
Development of zwitterionic polyurethane (ZPU) nanofibrous membranes with a positively charged zwitterionic moiety backbone, which are electrospun to create a mechanically robust, hydrophilic, and antifouling encapsulation device that prevents cell escape and induces minimal cellular deposition.
The ZPU device ensures adequate mass delivery, maintains mechanical robustness, prevents cell entry and escape, and supports long-term functionality with minimal foreign body response, effectively managing diabetes for up to 3 months in diabetic mice.