Polynucleotides comprising a micro RNA detargeting sensor and uses thereof

EP4750496A1Pending Publication Date: 2026-06-03STRAND THERAPEUTICS INC
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Patent Information

Authority / Receiving Office
EP · EP
Patent Type
Applications
Current Assignee / Owner
STRAND THERAPEUTICS INC
Filing Date
2024-07-25
Publication Date
2026-06-03

AI Technical Summary

Technical Problem

Current nucleic acid-based therapies, such as mRNA vaccines, face challenges in achieving tissue-specific and cell-specific expression of payload proteins, and existing delivery platforms are inefficient and associated with undesirable side effects.

Method used

Development of isolated polynucleotides comprising a first region encoding a payload and a second region with a sensor that specifically recognizes markers expressed by immune cells, such as microRNA miR-142, to reduce payload expression in immune cells and lymphoid tissues.

Benefits of technology

The described approach allows for selective regulation of payload expression, reducing its levels in immune cells and lymphoid tissues, thereby enhancing the therapeutic efficacy and reducing side effects of nucleic acid-based therapies.

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Abstract

The present disclosure relates to polynucleotides comprising (a) a first region encoding a payload and (b) a second region comprising an immune cell detargeting sensor (e.g., a spleen detargeting sensor). Upon recognition of the marker by the sensor, the expression of the encoded payload is reduced or inhibited. Also provided herein are replicons, nanoparticles, synthetic circuits, pharmaceutical compositions comprising such polynucleotides. Methods of using the polynucleotides, replicons, synthetic circuits, nanoparticles, and pharmaceutical compositions are also provided.
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