Film-forming composition and its use for the treatment of skin conditions

Abstract

The present invention relates to a liquid composition for application to the skin, integuments or mucous membranes, containing at least two grades of hydroxypropylcellulose, at least one of which has a molecular weight of at least 800,000 and the other of which has a molecular weight of less than 400,000, at least ethylcellulose, at least one hydroxypropylcellulose plasticizer, at least one ethylcellulose plasticizer, at least one organic solvent and at least one inorganic solvent. Once applied to the skin, integuments or mucous membranes, the solvents evaporate and the composition forms a protective solid film on the skin, integuments or mucous membranes which can be advantageously used in the treatment of skin conditions, in particular acne.

Description

Title of the invention: Film-forming composition and its use for the treatment of skin conditions

[0001] The present invention relates to a liquid composition intended to be applied to the skin, the appendages or the mucous membranes, containing at least two grades of hydroxypropylcellulose, at least one of which has a molecular weight of at least 800,000 and the other has a molecular weight of less than 400,000, at least ethylcellulose, at least one plasticizer of the hydroxypropylcellulose, at least one plasticizer of the ethylcellulose, at least one organic solvent and at least one inorganic solvent. Once applied to the skin, the appendages or the mucous membranes, the solvents evaporate and the composition forms a protective solid film on the skin, the appendages or the mucous membranes which can be advantageously used in the treatment of skin conditions, in particular acne. Technical field

[0002] The present invention may find applications in the cosmetic field or the field of medical devices, such as, for example, the prevention or treatment of conditions of the skin, appendages and mucous membranes. Prior art

[0003] Film-forming compositions can be formulated in aqueous phase or in solvent phase. They are generally in the form of a fluid which is applied to the skin, appendages or mucous membranes using a suitable applicator, such as a spray, a brush, a roll-on, a spatula, a palette or a pen. The water or solvent which they contain evaporates on contact with the skin, appendages or mucous membranes so as to form a solid film which protects the skin, appendages or mucous membranes, the constituents of which penetrate the skin, appendages or mucous membranes to a very limited extent. These compositions have the advantage of protecting the tissues by avoiding bacterial contamination while allowing them to breathe.

[0004] Film-forming compositions based on hydroxypropylcellulose containing a solvent have already been described in the prior art.

[0005] Thus, document US 5,081,158 describes a film-forming composition based on hydroxypropylcellulose (HPC), volatile solvent and weak carboxylic acid. This composition is intended, in particular, for mucous membranes and relates more particularly to a method of treating canker sores.

[0006] Document WO2005 / 039499 discloses in Example 29: a continuous topical film which is formed by at least two grades of derived cellulose, comprising Methocel E5 (HPMC MW 140,000) and Klucel JF (HPC MW140,000), sorbitol as plasticizer, water and ethanol. At least one other grade of derived cellulose (Methocel E50 MW 30,000) is present.

[0007] Document WO 2010086723 describes a topical film-forming composition for the treatment of fungal infections, comprising as film-forming polymer Klucel HF (HPC MW 850,000), ethanol and water and optionally adding plasticizers.

[0008] However, the formulas described in these patents have several drawbacks. Their durability over time, particularly when applied to the skin, is not satisfactory. The film formed is not aesthetic: it very quickly shows cracks.

[0009] Also, the film formed is not flexible, it does not follow the roughness and movements of the skin and thus causes discomfort.

[0010] Document EP 2 968 197 relates to a film-forming composition comprising two grades of hydroxypropylcellulose, an organic solvent, an inorganic solvent and a plasticizer. However, the formulas described in this patent have several drawbacks. The films formed, when the composition is applied to the skin, tend to peel off around their edges. Also, these films do not resist washing with water.

[0011] The Applicant therefore wished to develop a film-forming composition which can satisfactorily cover an area of ​​skin, while forming a continuous, flexible, conformable film of sufficient thickness which is resistant to washing with water, but also to washing with soapy water, and which is resistant to makeup which would be applied to its surface. The product of the invention can be advantageously applied to an area of ​​the skin subject to movement, tension or stretching, in particular on the face or joints.

[0012] The Applicant has discovered that by combining at least two grades of hydroxypropylcellulose, at least one of which has a molecular weight of at least 800,000 and the other has a molecular weight of less than 400,000, at least ethylcellulose, at least one hydroxypropylcellulose plasticizer, at least one ethylcellulose plasticizer, at least one organic solvent and at least one inorganic solvent in particular proportions, a composition is obtained which forms a homogeneous film on the skin which has good resistance over time, the aesthetic appearance of which is improved. Also, by combining the inorganic solvent with an organic solvent, a composition is obtained whose drying time to form a film is rapid and which, when applied to damaged skin, causes pain which remains acceptable.Preferably, when the two grades of hydroxypropylcelluloses and ethylcellulose are present in proportions and quantities making it possible to obtain a composition whose viscosity is such that it does not flow before drying (in order to avoid dripping outside the area of ​​interest) when. the latter is too liquid and that it is not too difficult to apply and does not form a film that is too thick which will take longer to dry if the latter is too viscous.

[0013] The Applicant has thus developed a new film-forming composition base with good durability, resistance to washing, perspiration and sweating, and satisfactory resistance to friction. The films are also flexible and provide sufficient comfort to the user, particularly when the composition is applied to an area subject to movement, tension or stretching. The films formed are discreet and are not sticky on the surface opposite that coming into contact with the skin, appendages or mucous membranes.

[0014] The present invention therefore relates to a topical film-forming composition containing at least two grades of hydroxypropylcellulose, at least one of which has a molecular weight of at least 800,000 and the other has a molecular weight of less than 400,000, at least ethylcellulose, at least one plasticizer, at least one organic solvent and at least one inorganic solvent, characterized in that:

[0015] -hydroxypropylcellulose having a molecular weight of at least 800,000 represents from 0.02 to 3% by weight of the total weight of the composition,

[0016] -hydroxypropylcellulose having a molecular weight of less than 400,000 represents 0.2 to 10% by weight of the total weight of the composition,

[0017] -ethylcellulose represents 0.2 to 5% by weight of the total weight of the composition

[0018] -the hydroxypropylcellulose plasticizer represents from 0.05 to 4% by weight of the total weight of the composition,

[0019] -the ethylcellulose plasticizer represents from 0.05% to 3% by weight of the total weight of the composition,

[0020] -the inorganic solvent represents 0.5 to 10% by weight of the total weight of the composition,

[0021] -the organic solvent represents 60 to 95% by weight of the total weight of the composition

[0022] - Ethylcellulose and hydroxypropylcellulose having a molecular weight of at less than 800,000 representing from 3 to 6% by weight of the total weight of the composition.

[0023] By “topical composition” is meant a composition intended to be applied to the skin, appendages or mucous membranes.

[0024] Preferably, the hydroxypropylcellulose having a molecular weight greater than 800,000 is present in a content ranging from 0.1 to 2.5% by weight of the total weight of the composition.

[0025] More preferably, the hydroxypropylcellulose having a molecular weight of less than 400,000 is present in a content ranging from 2 to 7.5% by weight of the total weight of the composition.

[0026] The molecular weight of hydroxypropylcellulose is measured as molecular weight by weight by size exclusion chromatography.

[0027]

[0028] Film-forming polymer

[0029] In addition to the two grades of hydroxypropylcellulose and ethylcellulose, the composition according to the invention may comprise other film-forming polymers. According to the present invention, the term "film-forming polymer" means a polymer capable of forming, on its own or in the presence of an auxiliary film-forming agent, a continuous and adherent film on a support, in particular on the skin, mucous membranes or superficial body hair.

[0030] Among these polymers, mention may be made, by way of example, of synthetic polymers, of radical type or of polycondensate type, polymers of natural origin and their mixtures.

[0031] The polymers of natural origin may be, for example, guar gums, arabic gums, alginates, xanthan gum, gelatin, chitosan, silicates, hydrated silicas, cellulosic polymers other than hydroxypropylcellulose as well as derivatives of these polymers.

[0032] The cellulose polymers may be chosen from hydroxypropylmethylcellulose, cellulose ethers, cellulose esters, nitrocelluloses, cellulose acetate, cellulose acetate butyrate, cellulose acetate propionate, water-soluble or insoluble cellulose derivatives, and mixtures thereof.

[0033] The film-forming polymers may also be chosen from polyurethanes, polyesters, polyester amides, polyamides, polyureas, vinyl polymers, acrylic polymers, polyvinyl butyrals, alkyd resins, resins derived from aldehyde condensation products such as arylsulfonamide formaldehyde resins, arylsulfonamide epoxy resins, ethyltosylamide resins, acetophenone / formaldehyde resins, PolyVinylMethyl ether and Maleic Anhydride (PVM / MA) copolymer and mixtures thereof.

[0034] The vinyl polymers may result from the homopolymerization or copolymerization of monomers chosen from vinyl esters such as vinyl acetate, vinyl neodecanoate, vinyl pivalate, vinyl benzoate and vinyl t-butyl benzoate and styrenic monomers such as styrene and alpha-methyl styrene.

[0035] The acrylic polymers may be homopolymers of acrylic acid, copolymers of acrylic acid, homopolymers of methacrylic acid or copolymers of methacrylic acid.

[0036] Hydroxypropylcellulose plasticizer

[0037] The film-forming composition according to the invention comprises at least one hydroxypropylcellulose plasticizer. In particular, mention may be made, alone or as a mixture, of the usual plasticizers, such as: - fatty alcohols such as octyldodecanol, 2-butyloctanol, 2-hexyl decanol, 2-undecylpentadecanol, oleyl alcohol; - glycols and their derivatives, such as glycerin, diethylene glycol ethyl ether, diethylene glycol methyl ether, diethylene glycol butyl ether or diethylene glycol hexyl ether, ethylene glycol ethyl ether, ethylene glycol butyl ether, ethylene glycol hexyl ether; - fatty acids such as oleic acid, linoleic acid, linolenic acid; - glycol esters such as triacetin (or glyceryl triacetate); - propylene glycol derivatives and in particular propylene glycol phenyl ether, propylene glycol diacetate, dipropylene glycol ethyl ether, tripropylene glycol methyl ether, propylene glycol butyl ether; - acid esters, in particular carboxylic acids, such as citrates, phthalates, adipates, carbonates, tartrates, phosphates, sebacates and in particular monocarboxylic acid esters such as isononyl isononanoate, oleyl erucate or octyl-2-docecyl neopentanoate; - oxyethylenated derivatives, such as oxyethylenated oils, in particular vegetable oils, such as sesame oil, castor oil, almond oil, canola oil, hazelnut oil, pistachio oil, linseed oil, borage oil, hemp oil, jojoba oil, sunflower oil, wheat germ oil, corn and / or corn germ oil, peanut oil, avocado oil, safflower oil, rapeseed oil, olive oil, argan oil, sunflower oil, grape seed oil, soybean oil, walnut oil, pumpkin seed oil, palm oil, coconut oil, and mixtures thereof. The oil can also be a derivative of one of the vegetable oils mentioned above. It can be hydrogenated or not, peroxidized or not; - and their mixtures.

[0038] According to a preferred embodiment, the plasticizer is chosen from glycols, in particular glycerin. Indeed, glycerin has the advantage of softening the film, moisturizing the skin (or mucous membrane) and promoting the diffusion of the active ingredient(s) when the composition contains it.

[0039] The plasticizer content of the hydroxypropylcellulose may range from 0.05% to 4% by weight, and in particular from 0.5 to 2% by weight, relative to the total weight of the composition.

[0040] Ethylcellulose plasticizer

[0041] The film-forming composition according to the invention comprises at least one ethylcellulose plasticizer. In particular, mention may be made, alone or as a mixture, of the usual plasticizers, such as: - fatty alcohols such as octyldodecanol, 2-butyloctanol, 2-hexyl decanol, 2-undecylpentadecanol, oleyl alcohol; - glycols and their derivatives, such as glycerin, diethylene glycol ethyl ether, diethylene glycol methyl ether, diethylene glycol butyl ether or diethylene glycol hexyl ether, ethylene glycol ethyl ether, ethylene glycol butyl ether, ethylene glycol hexyl ether; - fatty acids such as oleic acid, linoleic acid, linolenic acid; - glycol esters such as triacetin (or glyceryl triacetate); - propylene glycol derivatives and in particular propylene glycol phenyl ether, propylene glycol diacetate, dipropylene glycol ethyl ether, tripropylene glycol methyl ether, propylene glycol butyl ether; - acid esters, in particular carboxylic acids, such as citrates, phthalates, adipates, carbonates, tartrates, phosphates, sebacates and in particular monocarboxylic acid esters such as isononyl isononanoate, oleyl erucate or octyl-2-docecyl neopentanoate; - oxyethylenated derivatives, such as oxyethylenated oils, in particular vegetable oils, such as sesame oil, castor oil, almond oil, canola oil, hazelnut oil, pistachio oil, linseed oil, borage oil, hemp oil, jojoba oil, sunflower oil, wheat germ oil, corn and / or corn germ oil, peanut oil, avocado oil, safflower oil, rapeseed oil, olive oil, argan oil, sunflower oil, grape seed oil, soybean oil, walnut oil, pumpkin seed oil, palm oil, coconut oil, and mixtures thereof. The oil can also be a derivative of one of the vegetable oils mentioned above. It can be hydrogenated or not, peroxidized or not; - and their mixtures.

[0042] According to a preferred embodiment, the plasticizer is chosen from acid esters, in particular carboxylic acid esters, such as citrates, phthalates, adipates, carbonates, tartrates, phosphates, sebacates and in particular monocarboxylic acid esters such as isononyl isononanoate, oleyl erucate or octyl-2-docecyl neopentanoate, preferably, the plasticizer of ethylcellulose is triethyl citrate. Indeed, triethyl citrate has the advantage, in addition to softening the film, of having an antibacterial role, particularly interesting when the composition is intended to treat a skin condition of bacterial origin, but also a role of preservative of the composition.

[0043] The plasticizer content of the ethylcellulose can range from 0.05% to 3% by weight, and in particular from 1 to 3% by weight, relative to the total weight of the composition.

[0044] Solvents

[0045] The compositions of the invention contain at least one organic solvent and at least one inorganic solvent.

[0046] These solvents make it possible to solubilize some or all of the ingredients of the composition and contribute to the formation of a film on the skin during its application.

[0047] As organic solvents which can be used in the context of the present invention, mention may be made of:

[0048] - ketones such as methyl ethyl ketone, methyl isobutyl ketone, diisobutyl ketone, isophorone, cyclohexanone, acetone;

[0049] - alcohols such as ethanol, isopropanol, n-propanol, n-butanol, diacetone alcohol, 2-butoxyethanol, cyclohexanol;

[0050] - propylene glycol ethers such as propylene glycol monomethyl ether, propylene glycol monomethyl ether acetate, dipropylene glycol mono n-butyl ether;

[0051] - esters such as ethyl acetate, methyl acetate, propyl acetate, n-butyl acetate, isopentyl acetate;

[0052] - ethers such as diethyl ether, dimethyl ether or dichlorodiethyl ether; and

[0053] - their mixtures.

[0054] The organic solvent represents 60 to 95% by weight of the total weight of the composition, preferably 70 to 90% by weight of the total weight of the composition.

[0055] According to a preferred embodiment, the organic solvent is volatile.

[0056] By "volatile organic solvent" is meant an organic solvent capable of evaporating on contact with the skin in less than one hour, at room temperature and atmospheric pressure. The volatile organic solvent is liquid at room temperature, in particular has a non-zero vapor pressure at room temperature and atmospheric pressure, in particular it has a vapor pressure ranging from 0.13 Pa to 40,000 Pa (10-3 to 300 mm Hg), and preferably ranging from 1.3 Pa to 8000 Pa (0.01 to 60 mm Hg).

[0057] According to a particularly preferred embodiment, the organic solvent is chosen from alcohols which are liquid at room temperature such as ethanol, isopropanol, diacetone alcohol, 2-butoxyethanol, cyclohexanol and mixtures thereof, and preferably ethanol.

[0058] The inorganic solvent represents 0.5 to 10% by weight of the total weight of the composition, preferably 1 to 5% by weight of the total weight of the composition.

[0059] The inorganic solvent will advantageously be water.

[0060] The Applicant has found that advantageously, when these two solvents are combined in such proportions, a good compromise is obtained between the drying time and the pain felt when applying the composition to damaged skin. Indeed, ethanol has the advantage of volatilizing quickly but causes pain on application. By adding water in this proportion, the pain is reduced while having an acceptable drying time (in particular less than 120 seconds).

[0061] Another advantage of using a mixture of organic solvent and inorganic solvent is that a greater number of compounds, such as active ingredients, can be dissolved.

[0062] Additives

[0063] The composition according to the invention may comprise one or more pharmaceutically acceptable additives, such as for example perfumes, aromas, colorants, pigments, matting agents, rheological agents, preservatives, vitamins, essential oils and active agents, in particular chosen from antibacterial agents, antiseptics, antivirals, antifungal agents, painkillers, anti-inflammatories, healing agents, moisturizing agents, depigmenting agents, keratolytic agents, restructuring active ingredients, anesthetics and sunscreens.

[0064] In particular, the active ingredients that can be introduced into the composition according to the invention can be chosen from: - antibacterials such as Polymyxin B, penicillins (Amoxycillin), clavulanic acid, tetracyclines, Minocycline, chlortetracycline, aminoglycosides, Amikacin, Gentamicin, Neomycin, silver and its salts (Silver Sulfadiazine), probiotics; - antiseptics such as sodium mercurothiolate, eosin, chlorhexidine, phenylmercury borate, hydrogen peroxide, Dakin's solution, triclosan, biguanide, hexamidine, thymol, Lugol's, Povidone iodine, Merbromine, Benzalkonium and Benzethonium Chloride, ethanol, isopropanol; - antivirals such as Aciclovir, Famciclovir, Ritonavir; antifungals such as polyenes, Nystatin, Amphotericin B, Natamycin, imidazoles (Miconazole, Ketoconazole, Clotrimazole, Econazole, Bifonazole, Butoconazole, Fenticonazole, Isoconazole, Oxiconazole, Sertaconazole, Sulconazole, Thiabendazole, Tioconazole), triazoles (Fluconazole, Itraconazole, Ravuconazole, Posaconazole, Voriconazole), allylamines, Terbinafine, Amorolfine, Naftifine, Butenafine; Flucytosine (antimetabolite), Griseofulvin, Caspofungin, Micafungin; painkillers such as Paracetamol, Codeine, Dextropropoxyphene, Tramadol, Morphine and its derivatives, Corticosteroids and derivatives; anti-inflammatory drugs such as glucocorticoids, nonsteroidal anti-inflammatory drugs, aspirin, ibuprofen, ketoprofen, flurbiprofen, diclofenac, aceclofenac, ketorolac, meloxicam, piroxicam, tenoxicam, naproxen, indomethacin, naproxcinod, nimesulide, celecoxib, etoricoxib, parecoxib, rofecoxib, valdecoxib, phenylbutazone, niflumic acid, mefenamic acid; active ingredients promoting healing such as Retinol, Vitamin A, Vitamin E, N-acetyl-hydroxyproline, Centella Asiatica extracts, papain, silicones, essential oils of thyme, niaouli, rosemary, tea tree and sage, hyaluronic acid, synthetic polysulfated oligosaccharides having 1 to 4 ose units such as potassium salt of octasulfated sucrose, silver salt of octasulfated sucrose or sucralfate, Allantoin; moisturizing agents such as hyaluronic acid, urea, glycerol, fatty acids, aquaporin modulators, vegetable oils, chitosan, certain sugars including sorbitol, butters and waxes; depigmenting agents such as kojic acid (KojicAcid SL® -Quimasso (Sino Lion)), Arbutin (Olevatin® - Quimasso (Sino Lion)), the mixture of sodium palmitoylpropyl and white water lily extract (Sepicalm® - Seppic), undecylenoyl phenylalanine (Sepiwhite® - Seppic), licorice extract obtained by fermentation Aspergillus and ethoxydiglycol (GatulineWhitening® - Gattefossé), octadecenedioic acid (ODA White® - Sederma), alpha-arbutin (Alpha-arbutin®, SACLCFPA (Pentapharm)), aqueous extract of Arctophylos Uva Ursi leaves (Melfade-J® - SACL CFPA (Pentapharm)), Gigawhite® complex plant mixture (SACL CFPA (Alpaflor)), diacetylboldine (Lumiskin® - Sederma), extract of Japanese mandarin (Melaslow® - Sederma), the mixture of lemon extract enriched with citric acid and cucumber extract (Uninontan®U-34 - Unipex), the mixture of Rumex occidentalis extract and vitamin C (Tyrostat® 11 - Unipex), oligopeptides (Melanostatin 5® - Unipex), dipalmitatekojic (KAD-15® - Quimasso (Sino Lion)), the natural origin complex Vegewhite® from LCW, wheat germ extracts (Clariskin® II - Silab), ethyldiaminetriacetate (EDTA); - keratolytic agents such as salicylic acid, zinc salicylate, ascorbic acid, alpha hydroxy acids (glycolic, lactic, malic, citric, tartaric acid), extracts of Silver Maple, Morello Cherry, Tamarind, urea, the topical retinoid Kératoline® (Sederma), proteases obtained by fermentation of Bacillus Subtilis, the product Linked-Papain® (SACI-CFPA), papain (proteolytic enzyme from papaya fruit); - restructuring active ingredients (for example, restructuring of the appendages) such as silica derivatives, vitamin E, chamomile, calcium, horsetail extract, silk Lipester, ceramides; - anesthetics such as benzocaine, lidocaine, dibucaine, pramoxine hydrochloride, bupivacaine, mepivacaine, prilocaine, etidocaine; - sunscreens, such as chemical filters (Oxybenzone, Sulisobenzone, Dioxybenzone, Tinosorb S®, Avobenzone, 2-ethoxyethyl p-methoxycinnamate, Uvinul® A+, Mexoryl® XL, Octyl Methoxycinnamate or Octinoxate, Octyl Salicylate or Octisalate, Octyl Triazone or Uvinul® T 150, Methyl Salicylate, Meradimate, Enzacamene, MBBT or Tinosorb® M, Octyl Cyanophenylcinnamate or Parsol® 340, Para-aminobenzoic Acid, Ensulizole, Parsol® SLX or Polysiloxane-15 or Benzylidenemalonatepolysiloxane, Triethanolamine Salicylate or Trolamine Salicylate, Mexoryl® SX or Acid terephthalylidenedicamphosulfonic acid) and mineral filters (Zinc oxides, titanium dioxide, kaolin, ichthyol).

[0065] Preferably, when the composition is used in the treatment of acne, it comprises a keratolytic agent, preferably retinoic acid in association with a moisturizing and sebum-regulating active ingredient, preferably hyaluronic acid. More preferably, the composition according to the invention additionally contains an antibacterial, antifungal and anti-inflammatory active ingredient, preferably tea tree essential oil.

[0066] As indicated above, the composition according to the present invention is in the form of a liquid intended to be applied using a suitable applicator, such as a brush, a palette, a spray, a roll-on, a spatula or a pen.

[0067] Preparing a film

[0068] According to a second aspect, the invention relates to a process for obtaining a film from a topical film-forming composition as described above, characterized in that:

[0069] i. a topical film-forming composition according to any one of claims 1 to 7 is applied to tissues such as the skin, appendages or mucous membranes so as to form a uniform film

[0070] ii. Said film is dried for 30 seconds to 5 minutes

[0071] The thickness of the film before drying is for example greater than 500 nm, preferably between 1 and 300 μm, more preferably between 2 and 200 μm.

[0072] The invention also relates to a film capable of being obtained from the process according to the second aspect.

[0073] Use of the composition

[0074] The compositions according to the present invention are intended to be applied to the skin, appendages or mucous membranes. They can be advantageously used on wounds or scars, whether linked to an accident, an illness or the aftermath of a surgical intervention, burns, blisters, cracks or fissures, in the treatment of skin conditions such as, for example, acne, chickenpox, shingles, rosacea, first-degree burns, eczema, hyperpigmentation, lucite, vitiligo, xerosis, porphyria, stretch marks, psoriasis, insect bites, herpes, mouth ulcers.

[0075] The subject of the invention is therefore the composition as defined above for its use in the protection or treatment of wounds, scars, burns, blisters, mycoses, cracks, crevices, acne, chicken pox, shingles, rosacea, eczema, hyperpigmentation, light eruption, vitiligo, xerosis, prophylaxis, stretch marks, psoriasis, insect bites, herpes, mouth ulcers.

[0076] The subject of the invention is in particular the composition as defined above for its use in a method of treating acne.

[0077] Acne is an inflammatory dermatosis of the pilosebaceous follicles (glands secreting sebum, at the root of the hairs) with the formation of comedones.

[0078] Acne is a disease of the skin and more specifically of the pilosebaceous follicles. In this condition, the hair canal becomes blocked by sebum and dead cells, causing various lesions resulting from sebum retention, inflammation or infection of the pilosebaceous follicles.

[0079] Propionibacterium acnes is a bacterium that normally lives in everyone's follicles. It does not cause infection, but it aggravates follicle inflammation when there is excess sebum, causing red spots.

[0080] Among the known treatments, we can cite creams or ointments. They are essentially based on benzoyl peroxide and are available in drugstores (without a medical prescription). They are at least as effective as antibiotics and seem more active than local retinoids in inflammatory forms. Benzoyl peroxide can be irritating at high concentrations, the latter being no more effective than at lower concentrations. There are products that attack the bacteria (Propionibacterium acnes), others act on the mediators of inflammation, such as nicotinamide, a molecule naturally present in many foods. On the other hand, zinc helps reduce sebum secretion. Local retinoids are effective in inflammatory forms and on comedones. However, they are irritating at the start of treatment, sometimes with eczema (rarely), photosensitivity.They are teratogenic (possible malformation of a fetus before birth) and require the woman to take a contraceptive.

[0081] By applying the composition according to the invention to a skin rash at the first signs of the lesion, it is possible to limit the formation of comedones, papules, pustules or nodules. When applied after the formation of comedones, the composition according to the invention helps to limit the formation of papules, pustules or nodules.

[0082] Finally, the film obtained with the compositions of the invention also makes it possible to promote the healing of comedones, papules, pustules and nodules.

[0083] Cosmetic treatment method

[0084] The present invention also relates to a method of cosmetic treatment of the skin, comprising at least one application of the composition according to the present invention to skin imperfections every 24 hours in order to improve the appearance of the skin.

[0085] The present invention is illustrated in more detail in the non-limiting examples described below.

[0086] Examples 1: Formulations 1 to 12 of compositions according to the invention and comparative

[0087] The formulations of examples 1 to 12 were produced following the following protocol:

[0088] Tea Tree essential oil is added to ethanol with Citrofol AL. The mixture is then stirred with a deflocculating paddle until homogenized. The active ingredient HyRetin (example 1 to 12) is added to the water with magnetic stirring, which is maintained until the HyRetin is completely dissolved. Glycerin is then added with stirring. This mixture is then added to the ethanol mixture with stirring.

[0089] Hydroxypropylcellulose with a molecular weight of less than 400,000 (Klucel LF) is added to the mixture in a sprinkler and then left stirring for approximately 30 minutes (examples 1 to 12).

[0090] Once this grade of hydroxypropylcellulose is well incorporated, the high molecular weight hydroxypropylcellulose (Klucel MF) is added in a sprinkler and then left stirring for approximately one hour.

[0091] The ethylcellulose is then added and the mixture is left stirring for approximately 30 minutes.

[0092] Stirring is then stopped and left to stand for approximately 12 hours to allow the hydroxypropylcellulose to finish swelling before packaging the final product. Trade Name INCI Supplier Property % by weight relative to the total weight of the composition Ex. 1 According to the invention Ex. 2 According to the invention Ex. 3 Comparative Ex. 4 Comparative Ex. 5 Comparative Ex. 6 Comparative EC-N1 OOPha rm Ethylcellulo se Hercu les Filmogenic polymer 3.000 4.749 0.000 4.758 2.436 3.093 Klucel LFPh rm Hydroxypropylcellulose Hercu les Filmogenic polymer 4.500 7.124 4.639 7.137 3.653 4.639 Klucel MFPh rm Hydroxypropylcellulose Hercu les Filmogenic polymer 0.500 0.792 0.515 2.104 0.406 0.515 Glycer ine 481 0 Glycerol Oléon Hydroxypropylcellulose plasticizer 1.000 1.583 1.031 1.033 0.812 0.000 Citrofo 1AI Triethyl citrate Jungbu nzlau Ethylcellulose plasticizer 2.000 3.000 2.062 2.066 1.624 0.000 Demineralized water Demineralized water Solvent 2.000 3.166 2.062 3.172 1.624 2.062 Absolute ethanol Ethanol Charcoal Brabant Solvent 86.83 0 79.31 7 89.51 5 79.00 7 89.30 7 89.51 5 HyRet in Hyaluronic acid and retinoic acid Contip ro Keratolitic active + moisturizing active sebum regulator 0.020 0.032 0.021 0.032 0.016 0.021 Tea tree essential oil Tea tree essential oil Pierre Fabre Antibacterial, antifungal and anti-inflammatory active Anti-inflammatory 0.150 0.237 0.155 0.691 0.122 0.155 Quantity EC+HPC MF 3.5 5.541 0.515 6.862 2.842 3.608 Trade Name INCI Supplier Property % by weight relative to the total weight of the composition Ex. 7 Comparative Ex. 8 Comparative Ex. 9 Comparative Ex. 10 Comparative Ex. 11 Comparative Ex. 12 Comparative EC-N1 OOPha rm Ethylcellulo se Hercu les Filmogenic Polymer 2.956 2.899 5.472 1.502 3.000 0.000 Klucel LFPh arm Hydroxypropylcellulose Hercu les Filmogenic Polymer 4.433 4.348 2.202 6.467 4.500 4.523 Klucel MFPh arm Hydroxypropylcellulose Hercu les Filmogenic Polymer 0.493 0.483 0.497 0.497 0.500 3.015 Glycerin 48 10 Glycerol Oleocellulose Plasticizer 0.985 4.348 0.995 0.995 1.000 1.005 Citrofo 1AI Triethyl citrate Jungbu nzlau Ethylcellulose plasticizer 3.448 1.932 1.990 1.990 2.000 2.010 Demineralized water Waste water Demineralized water Solvent 1.970 1.932 1.990 1.990 12.00 0 2.01 Ethano 1 abso lu Ethanol Charb onnea u Brab ant Solvent 85.54 7 83.89 4 86.68 5 86.39 0 76.83 0 87.26 6 HyRet in Hyaluronic acid and retinoid Contip ro Keratol ytic active + moisturizing active sebum regulator 0.020 0.019 0.020 0.020 0.020 0.020 Tea tree essential oil Tea tree essential oil Pierre Fabre Antibacterial, antifungal and anti-inflammatory active 0.148 0.145 0.149 0.149 0.150 0.151 Quantity EC+HPC MF 3.449 3.382 5.969 1.999 3.5 3.015

[0093] Example 1: this example allows the production of a formula with a good drying time (less than 2 minutes) and a conformable film, which does not stick.

[0094] Example 2: this example allows obtaining a formula with an acceptable drying time and a suitable film thickness.

[0095] Example 3: In this example without ethylcellulose, the film comes off after washing because the HPCs do not resist washing with water.

[0096] Example 4: In this example, the quantity of ethylcellulose and hydroxypropylcellulose with a molecular weight of at least 800,000 is equal to 6.852. The composition obtained is too viscous, forms a film that is too thick during application, which increases its drying time.

[0097] Example 5: In this example, the amount of ethylcellulose and hydroxypropylcellulose with a molecular weight of at least 800,000 is equal to 2.842. The resulting composition is too liquid, the product runs during application and does not allow the product to be applied correctly.

[0098] Example 6: this example does not contain any plasticizer, neither for ethylcellulose nor for HPC, which forms a dry and brittle film.

[0099] Example 7: This example contains too much Citrofol AI, which plasticizes ethylcellulose, forming a sticky film.

[0100] Example 8: This example contains too much Glycerin, which allows HPCs to plasticize, forming a sticky film.

[0101] Example 9: This example contains too much ethylcellulose, which forms a dry, brittle film that is difficult to remove because this percentage of ethylcellulose makes it very resistant to water.

[0102] Example 10: This example does not contain enough ethylcellulose, which forms a fragile film that is not water resistant.

[0103] Example 11: This example contains too much water which forms a cloud in the formula over time, the formula is not stable.

[0104] Example 12: this example without ethylcellulose forms a film which does not resist washing.

Claims

Claims

1. A topical film-forming composition comprising at least two grades of hydroxypropylcellulose, at least one of which has a molecular weight of at least 800,000 and the other of which has a molecular weight of less than 400,000, at least ethylcellulose, at least one hydroxypropylcellulose plasticizer, at least one ethylcellulose plasticizer, at least one organic solvent and at least one inorganic solvent, characterized in that: - the hydroxypropylcellulose having a molecular weight of at least 800,000 represents from 0.02 to 3% by weight of the total weight of the composition, - the hydroxypropylcellulose having a molecular weight of less than 400,000 represents from 0.2 to 10% by weight of the total weight of the composition, - the ethylcellulose represents from 0.2 to 5% by weight of the total weight of the composition - the hydroxypropylcellulose plasticizer represents from 0.05 to 4% by weight of the total weight of the composition,- the ethylcellulose plasticizer represents from 0.05 to 3% by weight of the total weight of the composition, - the inorganic solvent represents from 0.5 to 10% by weight of the total weight of the composition, - the organic solvent represents from 60 to 95% by weight of the total weight of the composition. - Ethylcellulose and hydroxypropylcellulose having a molecular weight of at least 800,000 representing from 3 to 6% by weight of the total weight of the composition,

2. Composition according to claim 1, characterized in that the hydroxypropylcellulose having a molecular weight of at least 800,000 is present in a content ranging from 0.1 to 2.5% by weight, and the hydroxypropylcellulose having a molecular weight of less than 400,000 by weight is present in a content ranging from 2 to 7.5% by weight relative to the total weight of the composition.

3. Composition according to one of claims 1 or 2, characterized in that the hydroxypropylcellulose plasticizer is chosen from glycols, in particular glycerin.

4. Composition according to one of the preceding claims, characterized in that the ethylcellulose plasticizer is chosen from carboxylic acid esters, preferably citrates, preferentially triethyl citrates.

5. Composition according to any one of the preceding claims, characterized in that the organic solvent is chosen from alcohols which are liquid at room temperature such as ethanol, isopropanol, diacetone alcohol, 2-butoxyethanol, cyclohexanol and their mixtures, and preferably ethanol.

6. Composition according to any one of the preceding claims, characterized in that it comprises pharmaceutically acceptable additives, such as perfumes, flavors, colorants, pigments, matting agents, rheological agents, preservatives, vitamins, essential oils, antibacterial agents, antiseptics, antivirals, antifungal agents, painkillers, anti-inflammatories, healing agents, moisturizing agents, depigmenting agents, keratolytic agents, restructuring active ingredients, anesthetics and sunscreens.

7. Composition according to one of the preceding claims, characterized in that it comprises as additive a keratolytic agent, preferably retinoic acid in association with a moisturizing and sebum-regulating active ingredient, preferably hyaluronic acid and an antibacterial, antifungal and anti-inflammatory active ingredient, preferably tea tree essential oil.

8. A method of obtaining a film from a topical film-forming composition according to any one of claims 1 to 7, characterized in that: i. a topical film-forming composition according to any one of claims 1 to 7 is applied to tissues such as the skin, appendages or mucous membranes so as to form a uniform film ii. Said film is dried for 30 seconds to 5 minutes

9. Method according to claim 8, characterized in that the thickness of the film before drying is greater than 500 nm, preferably between 1 and 300 pm, more preferably between 2 and 200 pm.

10. Film obtainable from the process according to one of claims 8 or 9.

11. Composition according to one of claims 1 to 7, for its use in a method of treating acne.

12. Method of cosmetic treatment of the skin comprising at least one application of the composition according to one of claims 1 to 7 on skin imperfections every 24 hours in order to improve the appearance of the skin.