Oil-in-water emulsion comprising a semiochemical composition, suitable for administration in the form of a lotion

Abstract

The invention relates to the field of semiochemical products and describes, in particular, a composition in the form of an oil-in-water emulsion comprising an aqueous phase and an oily phase comprising a semiochemical composition, particularly suitable for administration, notably in the form of a lotion, as well as its preparation process. The invention also relates to the non-therapeutic use of the composition according to the invention for topical administration, particularly cutaneous administration, to an animal or a human.

Description

Title of the invention: Oil-in-water emulsion comprising a semiochemical composition, suitable for administration in the form of a lotion Technical field of the invention

[0001] The invention relates to the field of semiochemical products and describes, in particular, a composition in the form of an oil-in-water emulsion comprising an aqueous phase and an oily phase comprising a semiochemical composition, particularly suitable for administration, notably in the form of a lotion, as well as its preparation process. The invention also relates to the non-therapeutic use of the composition according to the invention for topical administration, particularly cutaneous administration, to an animal or a human. Prior art

[0002] The semiochemicals according to the invention correspond to mixtures of several chemical compounds, first described in particular by Silverstein, RM (1977). Semiochemicals are chemical substances emitted by a plant or animal that elicit a non-therapeutic behavioral or physiological response in another organism. When the semiochemical affects an individual of the same species (an "intraspecific" semiochemical), it is called a pheromone (Wyatt TD, 2003). There are several types of pheromones that enable different types of behavioral interactions or communication, for example, calming pheromones, sex pheromones, territorial marking pheromones, and alarm pheromones. When the semiochemical affects an individual of a different species (an "interspecific semiochemical"), it is called an allelochemical.Among allelochemical substances, an allomone is an allelochemical substance that triggers a reaction in the target species, this reaction being favorable to the species that releases the allomone (the opposite is a kairomone).

[0003] Since 1995, products whose active ingredients are semiochemical agents have been marketed. Some of their uses require application of the product to the animal's skin, for example, to achieve the desired effects on an animal in an open environment or to protect it against pests such as parasites or biting insects, or on human skin. The physicochemical constraints of the semiochemical components, and in particular their volatility and insolubility in water, have led to the use of excipients such as ethoxydiglycol in marketed products. The use of this type The use of excipients is increasingly limited by current regulations, but also by the general public, who tend to reject them due to their synthesis methods and their potential direct and environmental toxicity. It has therefore become necessary to develop aqueous formulations of semiochemical compounds that are non-toxic and environmentally friendly, particularly those compliant with Regulation (EC) No 1223 / 2009 of the European Parliament and of the Council of 30 November 2009 on cosmetic products. Presentation of the invention

[0004] The invention aims to develop a composition based on semiochemical products (also referred to as compounds, active ingredients or agents) in a new galenic form, preferably non-toxic and environmentally friendly, in particular in the form of an oil-in-water (O / W) emulsion, preferably in the form of a stable and homogeneous oil-in-water (O / W) emulsion, for topical administration, in particular cutaneous administration to an animal, in particular a mammal, or a human, or for topical administration, in particular cutaneous administration to farm animals treated in groups, in particular to prevent the establishment of invertebrates (blood-sucking or not) on the skin, or to prevent bites by blood-sucking invertebrates, in particular blood-sucking insects, such as mosquitoes, mites or ticks; or to prevent infestation by parasites such as the red poultry mite (Dermanyssus sp. or Omithonyssus sylviarum).Preferably, topical administration of the composition according to the invention is carried out by uniform application to one or more body areas, in particular to all the treated body areas, for example in the form of a continuous layer (uniformly and totally covering the treated body area). Summary of the invention

[0005] The invention is defined by the independent claims. The dependent claims define particular or preferred embodiments of the invention.

[0006] According to a first aspect, the invention relates to a composition in the form of an oil-in-water (O / W) emulsion (referred to as the O / W composition or composition according to the invention) comprising: a) an aqueous phase comprising water, at least one humectant selected from polyols and sugars, and at least one gelling agent selected from polysaccharides, b) an oily phase comprising at least one emollient, at least one emulsifying agent, and a semiochemical composition, in which said semiochemical composition comprises (i) 3-cyclopentyl propionic acid and 3-cyclohexyl propionic acid, or (ii) bis(ethyl-2 hexyl) adipate and l-isopropyl-2,2-dimethyltrimethylene diisobutyrate.

[0007] According to a second aspect, the invention relates to a method for preparing a composition according to the invention, comprising the following steps: a) at least one gelling agent is mashed in at least one humectant; then water is added under agitation and at a temperature between 65°C and 75°C, preferably at a temperature of 70°C, so as to obtain a homogeneous aqueous phase; b) said at least one emollient agent, said at least one emulsifying agent, said semiochemical composition and optionally said at least one additive are mixed together under agitation and at a temperature between 65°C and 75°C, preferably at a temperature of 70°C, so as to obtain a homogeneous oily phase; c) the oily phase from step b) is added under agitation to the aqueous phase from step a) so as to obtain an oil-in-water (O / W) emulsion; d) optionally, the pH of the emulsion obtained in step c) is adjusted; e) optionally a fragrance is added; f) the composition is recovered in the form of an oil-in-water (O / W) emulsion, in particular stable and homogeneous, obtained in step c), d) or e).

[0008] According to a third aspect, the invention relates to the non-therapeutic use of a composition according to the invention for topical administration, in particular cutaneous administration to an animal or a human, in particular on the skin of an animal or a human, in particular to prevent the establishment of invertebrates (blood-sucking or not) on the skin, or to prevent bites by blood-sucking invertebrates, in particular blood-sucking insects, such as mosquitoes, mites or ticks; or to prevent infestation by parasites such as the red poultry mite (Dermanyssus sp. or Ornithonyssus sylviarum). Detailed description of the invention

[0009] The invention is now described in more detail and without limitation in the following description. Unless otherwise stated, all percentages relating to quantities are mass percentages. Any reference to ranges of values ​​in the description and / or the claims implies, unless otherwise stated, that the bounds of the ranges are inclusive.

[0010] The invention relates to a composition in the form of an oil-in-water (O / W) emulsion comprising: a) an aqueous phase comprising water, at least one humectant selected from polyols and sugars, and at least one gelling agent selected from polysaccharides, b) an oily phase comprising at least one emollient, at least one emulsifying agent, and a semiochemical composition, in which said semiochemical composition comprises (i) acid 3-cyclopentyl propionic acid and 3-cyclohexyl propionic acid, or (ü) bis(ethyl-2 hexyl) adipate and l-isopropyl-2,2-dimethyltrimethylene diisobutyrate.

[0011] In a particular embodiment of the invention, said semio-chemical composition comprises (i) 40% to 60% by weight of 3-cyclopentyl propionic acid and 40% to 60% by weight of 3-cyclohexyl propionic acid, or (ii) 40% to 60% by weight of bis(ethyl-2 hexyl) adipate, and 40% to 60% by weight of l-isopropyl-2,2-dimethyltrimethylene diisobutyrate, the total sum of the compounds present in said semio-chemical composition being equal to 100%.

[0012] In a preferred embodiment of the invention, said semiochemical composition comprises (i) 50% by weight of 3-cyclopentylpropionic acid and 50% by weight of 3-cyclohexylpropionic acid, or (ii) 50% by weight of bis(2-ethylhexyl) adipate and 50% by weight of l-isopropyl-2,2-dimethyltrimethylene diisobutyrate. Galenic

[0013] The composition according to the invention is in the form of an oil-in-water (O / W) emulsion, in particular an oil-in-water emulsion that is stable and has a homogeneous appearance, especially to the naked eye. In particular, the composition is in the form of a milk, preferably a white milk, having an opaque and thick texture.

[0014] In the context of the invention, the term "emulsion" refers to a mixture of two immiscible liquid substances, such as oil and water. In an oil-in-water (O / W) emulsion, the oil is dispersed in the water in the form of droplets, particularly small droplets.

[0015] In the context of the invention, the term "stable emulsion" refers to an emulsion that does not show signs of instability (phase separation, increase in droplet size, ...), in particular an emulsion that does not release water or oil and that remains in its initial form over time and under different temperature conditions, for example during 3 months of storage at a temperature between 5°C and 40°C.

[0016] In the context of the invention, the term "homogeneous emulsion" refers to an emulsion whose surface is smooth and uniform to the naked eye. Aqueous phase

[0017] The composition according to the invention comprises an aqueous phase, in particular a continuous aqueous phase (also called the external phase).

[0018] The aqueous phase of the composition according to the invention comprises water, preferably demineralized water or purified water, and optionally one or more water-miscible or at least partially water-miscible compounds, by For example, a skin conditioning agent such as ALOE VERA, a hydrosol, urea, an antistatic agent.

[0019] In the context of the invention, the term "skin conditioning agent" refers to an agent that helps to maintain the skin in good condition, e.g., healthy-looking.

[0020] In the context of the invention, the term "antistatic agent" refers to an agent that reduces static electricity by neutralizing the electric charge on a surface.

[0021] In a particular embodiment of the invention, the composition according to the invention comprises from 60% to 95% by weight of water, preferably from 70% to 80% by weight of water, relative to the total weight of the composition.

[0022] In a preferred embodiment of the invention, the composition according to the invention comprises from 62% to 91% by weight of water, preferably from 73.0% to 76.5% by weight of water, even more preferably 74.4% (milk for application on an adult) or 76.1% (milk for application on a baby) by weight of water, relative to the total weight of the composition.

[0023] The aqueous phase of the composition according to the invention may comprise water, at least one humectant selected from polyols and sugars, and at least one gelling agent selected from polysaccharides. Humectant

[0024] According to a particular embodiment, the aqueous phase of the composition according to the invention further comprises at least one humectant selected from polyols and sugars. In particular, the aqueous phase of the composition according to the invention further comprises a single humectant selected from polyols or sugars, preferably polyols. Said at least one humectant is notably soluble in the aqueous phase.

[0025] In the context of the invention, the term "humectant" (also called a moisturizing agent) refers to a compound or mixture of compounds that retains water thanks to their hygroscopic power.

[0026] In the context of the invention, the term "polyol" refers to any organic compound comprising at least two free hydroxyl (-OH) groups such as glycols.

[0027] In the context of the invention, the term "sugar" refers to simple carbohydrates, in particular any organic molecule consisting of one monosaccharide or two monosaccharides.

[0028] In a particular embodiment of the invention, said at least one humectant is chosen from among the polyols selected from the group consisting of glycerol (also called glycerin), propylene glycol, polyethylene glycols (PEG), xylitol, isomalt, maltitol, mannitol, polydextrose, sorbitol, isomaltitol, lactitol, and mixtures thereof; and / or said at least one humectant is chosen from among the sugars selected from the group consisting of fructose, glucose, lactose, and their mixtures.

[0029] In a preferred embodiment of the invention, said at least one humectant is a polyol, in particular glycerol.

[0030] Said at least one humectant, i.e., one or more humectant(s), preferably one humectant, may be present in the composition in a content ranging from 4% to 12% or 4.5% to 12% by weight, preferably from 4% to 6% by weight, relative to the total weight of the composition.

[0031] Preferably, said at least one humectant is glycerol and is present in the composition in a content ranging from 4.5% to 12% by weight, preferably 5% by weight, relative to the total weight of the composition. Gelling agent

[0032] In a particular embodiment, the aqueous phase of the composition according to the invention further comprises at least one gelling agent selected from polysaccharides. In particular, the aqueous phase of the composition according to the invention further comprises a single gelling agent selected from polysaccharides. Said at least one gelling agent is, in particular, soluble in the aqueous phase. Said at least one gelling agent is a hydrophilic gelling agent.

[0033] In the context of the invention, the term "gelling agent" refers to an agent capable of increasing the viscosity of the oil-in-water emulsion, and / or enabling the cohesion of the different constituents of the composition.

[0034] In the context of the invention, the term "polysaccharides" (also called glycans, polyosides or polyholosides) refers to complex carbohydrates made up of the polymerization of sugars (monosaccharides) linked together by glycosidic bonds.

[0035] In a particular embodiment of the invention, the polysaccharides are chosen from the group consisting of xanthan gum, guar gum, cellulose, cellulose derivatives, maltodextrin, maltodextrin derivatives, and mixtures thereof, preferably xanthan gum.

[0036] Polysaccharides may be present in the composition in a content ranging from 0.05% to 1% or 0.05% to 0.9% by weight, preferably from 0.1% to 0.3% by weight, relative to the total weight of the composition.

[0037] Preferably, the polysaccharides are xanthan gum and are present in the composition in a content ranging from 0.05% to 0.9% by weight, preferably from 0.2% to 0.4% by weight, even more preferably from 0.2% by weight, relative to the total weight of the composition.

[0038] In a particular embodiment of the invention, the aqueous phase of the composition comprises glycerol in a content ranging from 4.5% to 12% by weight, preferably 5% by weight, and xanthan gum in a content ranging from 0.05% to 0.9% by weight, preferably 0.2% to 0.4% by weight, even more preferably 0.2% by weight, all percentages being given in relation to the total weight of the composition. Oily phase

[0039] The composition according to the invention comprises an oily phase, in particular a dispersed oily phase (also called discontinuous or internal phase).

[0040] The oily phase of the composition according to the invention may comprise at least one emollient agent, at least one emulsifying agent, and a semiochemical composition. In particular, said at least one emollient agent, said at least one emulsifying agent, and said semiochemical composition are specifically soluble in the oily phase.

[0041] The oily phase may be present in a concentration ranging from 3% to 30% by weight, preferably from 15% to 25% by weight, relative to the total weight of the composition. Emollient agent

[0042] According to a particular embodiment, the oily phase of the composition according to the invention further comprises at least one emollient agent, i.e., one or more emollient agents, preferably at least two emollient agents. Said at least one emollient agent is, in particular, soluble in the oily phase.

[0043] In the context of the invention, the term "emollient agent" refers to an agent that softens and smooths the skin when administered topically, in particular cutaneously, of the composition according to the invention.

[0044] In a particular embodiment of the invention, said at least one emollient agent is chosen from the group consisting of hydrogenated or non-hydrogenated vegetable oils, in particular vegetable oils comprising triglycerides of unsaturated fatty acids (for example, olive oil, rapeseed oil, sunflower oil, sesame oil, linseed oil, hemp oil, walnut oil, hazelnut oil, coconut oil, argan oil, jojoba oil, sweet almond oil, shea butter, castor oil, avocado oil, apricot kernel oil, macadamia oil, etc.), silicone oils (for example, dimethicone, etc.), mineral oils and waxes (for example, paraffin, etc.), fatty alcohols (for example, arachidic alcohol, batyl alcohol, etc.) behenyl alcohol, C12-C13 alcohols, cetearyl alcohol, cetyl alcohol, coconut alcohol, isocetyl alcohol, octyldodecanol, palm alcohol, ...), fatty acids and fatty acid esters (e.g., batyl stearate, cetearyl behenate, cetearyl iso-nonanoate, cetyl esters, coco acid, ethyl linoleate, ethyl linolenate, ethyl olivate, ethylhexyl cocoate, ethylhexyl myristate, glyceryl caprylate, glyceryl laurate / oleate, glyceryl ricinoleate, isocetyl salicylate, isostearyl alcohol, linoleic acid, linolenic acid, oleic acid, palm kernel acid, . palmitic acid, wheat germ acid, ...), glyceride derivatives (for example, capric / caprylic acid triglycerides, cocoglycerides, palm glycerides, ...), glycerol derivatives (for example, glycerol trioctanoate: Tricaprylin, glycerol tristearate: Tristearin...), and mixtures thereof; preferably said at least one emollient agent is a mixture of emollient agents consisting of glyceride derivatives such as fatty acid triglycerides, and vegetable oils comprising unsaturated fatty acid triglycerides.

[0045] Said at least one emollient agent, i.e., one or more emollient agent(s), preferably a mixture of two emollient agents, is present in a content ranging from 1% to 19% by weight, preferably from 4% to 6% by weight, relative to the total weight of the composition.

[0046] In a preferred embodiment of the invention, said at least one emollient agent is a fatty acid triglyceride, in particular a caprylic / capric acid triglyceride such as that marketed in particular by BASF under the name Myritol 318®, and is present in the composition in a content ranging from 0.5% to 8% by weight, preferably 3% by weight, relative to the total weight of the composition.

[0047] In another preferred embodiment of the invention, said at least one emollient agent is a vegetable oil comprising triglycerides of unsaturated fatty acids, in particular sunflower oil, and is present in the composition in a content ranging from 1% to 10.2% by weight, preferably 2% by weight, relative to the total weight of the composition.

[0048] In another even more preferred embodiment of the invention, said at least one emollient agent is a mixture of emollient agents consisting of glyceride derivatives such as fatty acid triglycerides, in particular a caprylic / capric acid triglyceride such as that marketed in particular by BASF under the name Myritol 318®, and vegetable oils comprising unsaturated fatty acid triglycerides, in particular sunflower oil, this mixture being present in the composition in a content ranging from 1% to 19% by weight, preferably from 4% to 6% by weight, even more preferably from 5% by weight, relative to the total weight of the composition.

[0049] In a particular embodiment of the invention, the aqueous phase of the composition comprises glycerol in a content ranging from 4.5% to 12% by weight, preferably 5% by weight, and xanthan gum in a content ranging from 0.05% to 0.9% by weight, preferably from 0.2% to 0.4% by weight, even more preferably from 0.2% by weight, and the oily phase of the composition comprises a mixture of emollients consisting of a caprylic / capric acid triglyceride such as Myritol 318® in a content ranging from 0.5% to 8% by weight, preferably from 3% by weight, and a vegetable oil comprising triglycerides of unsaturated fatty acids such as sunflower oil in a content ranging from 1% to 10.2% by weight, preferably 2% by weight, relative to the total weight of the composition, all percentages being given relative to the total weight of the composition. Emulsifying agent

[0050] The oily phase of the composition according to the invention further comprises at least one emulsifying agent, preferably one or more emulsifying agents. Said at least one emulsifying agent is in particular soluble in the oily phase.

[0051] Preferably, said at least one emulsifying agent is environmentally friendly, in particular compliant with Regulation (EC) No 1223 / 2009 of the European Parliament and of the Council of 30 November 2009 on cosmetic products. A person skilled in the art will therefore be able to choose an environmentally friendly emulsifying agent on the basis of this Regulation (EC) No 1223 / 2009.

[0052] In the context of the invention, the term "emulsifying agent" (also called emulsifying agent) refers to a small molecule composed of a hydrophilic head soluble in the aqueous phase and a lipophilic tail having an affinity for the oily phase. Said at least one emulsifying agent enables the formation of an interfacial film around the droplets in the dispersed phase, thus forming the emulsion and providing stability to this emulsion.

[0053] Said at least one emulsifying agent may be chosen from non-ionic or ionic (anionic, cationic) surfactants, preferably non-ionic surfactants.

[0054] In the context of the invention, the term "surfactant" refers to a compound that reduces surface tension and promotes a uniform distribution of the composition according to the invention during its use.

[0055] In a particular embodiment of the invention, said at least one non-ionic surfactant has a hydrophilic-lipophilic balance (HLB) between 8 and 20 at 25°C.

[0056] In a particular embodiment of the invention, said at least one emulsifying agent is an ionic surfactant, preferably an anionic surfactant selected from sulfated castor oil, sodium dodecyl sulfate (SDS), sodium coco sulfate (INCI name: Sodium coco sulfate (SCS)), sodium cocoyl isethionate (INCI name: Sodium cocoyl isethionate (SCI)), sodium lauryl sulfoacetate (INCI name: Sodium lauryl sulfoacetate (SLSA)), sodium laureth sulfate (INCI name: Sodium laureth sulfate (SLES)) and sodium lauroyl sarcosinate (INCI name: Sodium Lauroyl Sarcosinate), or a cationic surfactant selected from cetearyl alcohol (INCI name: Cetearyl Alcohol), behentrimonium methosulfate (INCI name: Sodium Lauroyl Sarcosinate) INCI: Be-hentrimonium Methosulfate (BTMS), Brassica Alcohol (and) Brassicyl Valinate Esylate (INCI Name: Brassica Alcohol (and) Brassicyl Valinate Esylate), the benzalkonium chlorides (BAC), didecyldimethylammonium chlorides (DDAC), brassicamidopropyl dimethylamine (INCI name: Brassicamidopropyl dimethylamine), Polyquaternium-7, Polyquaternium-10, Polyquaternium-22 and Polyquaternium-37.

[0057] In a preferred embodiment of the invention, said at least one emulsifying agent is a non-ionic surfactant, preferably a non-ionic surfactant having an HLB between 8 and 20 to 25°C, and is in particular selected from alkyl polyglucosides, mixtures of at least one alkyl polyglucoside and at least one fatty alcohol, fatty acid esters or alcohol and fatty acid esters.

[0058] Examples of alkyl polyglucosides (APGs) are known to those skilled in the art.

[0059] Mixtures of at least one alkyl polyglucoside and at least one fatty alcohol include in particular at least one alkyl polyglucoside in Ci2-C2o and at least one fatty alcohol in Ci4-C22 such as Montanov L® notably marketed by the company SEPPIC, a mixture of myristic alcohol and myristyl glucoside such as Montanov 14® notably marketed by the company SEPPIC.

[0060] Examples of fatty acid esters include, for example, glyceryl stearate, notably marketed under the name SustOleo GMS® by the company INOLEX.

[0061] Examples of alcohol and fatty acid esters include, for example, glycol palmitate, notably marketed under the name Lanol ​​P écaillés® by the company SEPPIC.

[0062] In a particular embodiment of the invention, said at least one emulsifying agent, i.e., one or more emulsifying agent(s), is present in the composition in a content ranging from 2% to 30% by weight, preferably from 10% to 12% by weight, relative to the total weight of the composition.

[0063] In a preferred embodiment of the invention, the composition according to the invention comprises several emulsifying agents, in particular a mixture of emulsifying agents consisting of alkyl polyglucosides, mixtures of at least one alkyl polyglucoside and at least one fatty alcohol, fatty acid esters, and alcohol and fatty acid esters, preferably a mixture of emulsifying agents consisting of mixtures of at least one alkyl polyglucoside and at least one fatty alcohol, fatty acid esters, and alcohol and fatty acid esters.

[0064] Preferably, said emulsifying agents are a C[2-C20] alkyl polyglucoside and at least one C[4-C22] fatty alcohol such as Montanov L®, notably marketed by SEPPIC, a mixture of myristic alcohol and myristyl glucoside such as Montanov 14®, notably marketed by SEPPIC, glyceryl stearate, notably marketed under the name SustOleo GMS® by INOLEX, and glycol palmitate, notably marketed under the The composition is designated Lanol ​​P écaillés® by the company SEPPIC, and the said emulsifying agents are present in the composition at a concentration ranging from 2.2% to 26.9% by weight, preferably 11.5% by weight, relative to the total weight of the composition. In particular, Montanov L® is present in the composition at a concentration ranging from 1.3% to 8.5% by weight, preferably 4.5% by weight, relative to the total weight of the composition; and / or Montanov 14® is present in the composition at a concentration ranging from 0.2% to 5.2% by weight, preferably 1% by weight, relative to the total weight of the composition; and / or SustOleo GMS® is present in the composition at a concentration ranging from 0.2% to 5.2% by weight, preferably 2% by weight, relative to the total weight of the composition; and / or Lanol ​​P écaillés® is present in the composition in a content ranging from 0.5% to 8.0% by weight, preferably 4.0% by weight, relative to the total weight of the composition.

[0065] In a particular embodiment of the invention, the aqueous phase of the composition comprises glycerol in a content ranging from 4.5% to 12% by weight, preferably 5% by weight, as well as xanthan gum in a content ranging from 0.05% to 0.9% by weight, preferably from 0.2% to 0.4% by weight, even more preferably from 0.2% by weight, and the oily phase of the composition comprises a mixture of emollients consisting of a caprylic / capric acid triglyceride such as Myritol 318® in a content ranging from 0.5% to 8% by weight, preferably 3% by weight, and a vegetable oil comprising triglycerides of unsaturated fatty acids such as sunflower oil in a content ranging from 1% to 10.2% by weight, preferably 2% by weight, as well as a mixture of agents emulsifiers consisting of Montanov L® present in the composition at a content ranging from 1.3% to 8.5% by weight, preferably 4.5% by weight, and Montanov 14® at a content ranging from 0.2% to 5%,2% by weight, preferably 1% by weight, of SustOleo GMS® in a content ranging from 0.2% to 5.2% by weight, preferably 2% by weight, and of Lanol ​​P écaillés® in a content ranging from 0.5% to 8.0% by weight, preferably 4.0% by weight, all percentages being given in relation to the total weight of the composition. semiochemical composition

[0066] The oily phase of the composition according to the invention further comprises a semiochemical composition as an active agent, as defined above. This semiochemical composition is, in particular, soluble in the oily phase described herein. Specific semiochemical compositions are described above and in the preferred embodiments and experimental examples that follow.

[0067] The semiochemical composition contained in the composition according to the invention is in particular intended for non-therapeutic use, for example, use for its protective effect against pests (parasites, insects, etc.) on the animals or humans to whom it is administered or on animals interacting with it. lastly, in the form of the H / E composition.

[0068] The semiochemical composition may be present in the composition in the form of an oil-in-water emulsion in a content ranging from 0.5% to 5% by weight, preferably from 1% to 2% by weight of said semiochemical composition, relative to the total weight of the W / E composition according to the invention. Additives

[0069] The composition according to the invention may further comprise at least one additive provided that it does not interfere with the desired properties of the composition, in particular with its property of being an O / W emulsion.

[0070] In a particular embodiment of the invention, said at least one additive is chosen from the group consisting of a preservative agent, in particular an antimicrobial agent or an antioxidant agent, a perfume, a masking agent, and mixtures thereof.

[0071] In the context of the invention, the term "preservative agent" refers to an agent that protects the composition according to the invention from changes in its physical or chemical state, color, or odor, or that protects it from contamination or microbial degradation, for example, by inhibiting the growth of microorganisms during the storage or use of the composition according to the invention. Such an agent must be compatible with the use of the composition according to the invention in contact with an animal or a human, and is advantageously non-irritating to the skin and eyes.

[0072] Examples of preservatives are known to those skilled in the art and include, in particular, benzyl alcohol, didecyldimonium chloride, caprylyl glycol, phenylpropanol, sodium benzoate, phenyl acetate, sorbic acid, dehydroacetic acid, potassium sorbate, phenoxyethanol, cetrimonium bromide, triclosa, parabens, thiazolinones.

[0073] In the context of the invention, the term "antimicrobial agent" therefore refers to a preservative agent that slows the growth of microorganisms (bacteria, fungi, yeasts, molds) and combats the development of microbes in the composition according to the invention, when stored and / or when used.

[0074] Examples of antimicrobial agents are known to those skilled in the art and include, in particular, Glycerin / phenyl alcohol / caprylhydroxamic acid, notably marketed under the name Aromastat® by the company INOLEX.

[0075] The composition according to the invention may comprise from 0% to 4% by weight, preferably from 0.2% to 3.2% by weight, even more preferably 1% by weight of preservative agent, in particular antimicrobial agent, relative to the total weight of the composition according to the invention.

[0076] In the context of the invention, the term “antioxidant agent” refers to a preservative agent capable of inhibiting reactions favored by oxygen, thus preventing oxidation.

[0077] Examples of antioxidant agents are known to those skilled in the art and include, in particular, compounds of the cinnamic acid family and their derivatives, such as pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate, notably marketed under the name Tinogard TT® by BASF, vitamin A (retinol), vitamin C (ascorbic acid) and derivatives (ascobate), vitamin E (tocopherol) and derivatives (tocopheryl), preferably Tinogard TT®.

[0078] The composition according to the invention may comprise from 0% to 2% by weight, preferably from 0.02% to 0.3% by weight, even more preferably 0.1% by weight of antioxidant agent, relative to the total weight of the composition.

[0079] In the context of the invention, the term “perfume” or perfumer refers to any hydrophobic substance designating a pure body or a mixture insoluble or very slightly soluble in water capable of giving off a pleasant odor.

[0080] The composition according to the invention may comprise from 0% to 3% by weight, preferably from 0.2% to 2.5% by weight, even more preferably 2% by weight of perfume, relative to the total weight of the composition.

[0081] In the context of the invention, the term “masking agent” refers to an agent that reduces or inhibits the basic odor or taste of the product.

[0082] Examples of masking agents are known to those skilled in the art and include, in particular, beta sitosterol, citric acid, bisabolol, calendula offi-cienalis flower extract.

[0083] The composition according to the invention may comprise from 0% to 3% by weight, preferably from 0.2% to 2.5% by weight, even more preferably 1% or 2% by weight of a masking agent, relative to the total weight of the composition.

[0084] In a particular embodiment according to the invention, said at least one additive is added to the oily phase, i.e., the oily phase further comprises at least one additive as defined above.

[0085] In another particular embodiment according to the invention, said at least one additive, for example a perfume, is added after the formation of the oil-in-water emulsion, or after a step of adjusting the pH of the oil-in-water emulsion.

[0086] In a preferred embodiment according to the invention, the oily phase further comprises at least one additive selected from the group consisting of a preservative, in particular an antimicrobial agent or an antioxidant agent, a perfume, a masking agent, and mixtures thereof, even more preferably at least one additive selected from the group consisting of a preservative, in particular an antimicrobial agent or an antioxidant agent, a masking agent, and mixtures thereof.

[0087] In another preferred embodiment according to the invention, the composition according The invention further includes at least one additive such as a fragrance. This fragrance is added, in particular, after the formation of the oil-in-water emulsion or after a step of adjusting the pH of the oil-in-water emulsion in order to prevent the degradation of the fragrance or the loss of its scent.

[0088] In a preferred embodiment of the invention, the composition comprises: a) an aqueous phase comprising water, glycerol, and xanthan gum; b) an oily phase comprising at least one alkyl polyglucoside in the form C12-C20 and at least one fatty alcohol in the form C14-C22 (Montanov L®, notably marketed by SEPPIC), a mixture of myristic alcohol and myristyl glucoside (Montanov 14®, notably marketed by SEPPIC), caprylic / capric acid triglycerides (Myritol 318®, notably marketed by BASF), sunflower oil, glyceryl stearate (SustOleo GMS®, notably marketed by INOLEX), glycol palmitate (Lanol ​​P écaillés®, notably marketed by SEPPIC), and pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate (Tinogard TT® notably marketed by BASF),Glycerin / phenyl alcohol / caprylhydroxamic acid (Aromastat®, notably marketed by INOLEX), a fragrance, and a semiochemical composition, the semiochemical composition being present in the composition according to the invention at a concentration ranging from 0.5% to 5% by weight, preferably from 1% to 2% by weight, relative to the total weight of the W / E composition according to the invention.

[0089] In an even more preferred embodiment of the invention, the composition according to the invention comprises: a) an aqueous phase comprising water in a content of 62% to 91% by weight, preferably 73.0% to 76.5% by weight, even more preferably 74.4% or 76.1% by weight, glycerol in a content of 4.5% to 12% by weight, preferably 5% by weight, and xanthan gum in a content of 0.05% to 0.9% by weight, preferably 0.2% to 0.4% by weight, even more preferably 0.2% by weight, b) an oily phase comprising at least one alkyl polyglucoside in the C12-C20 range and at least one fatty alcohol in the C14-C22 range (Montanov L®, notably marketed by SEPPIC) in a content ranging from 1.3% to 8.5% by weight, preferably 4.5% by weight; a mixture of myristic alcohol and myristyl glucoside (Montanov 14®, notably marketed by SEPPIC) in a content ranging from 0.2% to 5.2% by weight, preferably 1% by weight; caprylic / capric acid triglycerides (Myritol 318®, notably marketed by BASF) in a content ranging from 0.5% to 8% by weight, preferably 3% by weight; sunflower oil in a content ranging from 1% to 10.2% by weight, preferably 2% by weight; glyceryl stearate (SustOleo GMS® notably marketed by the company INOLEX) in a content ranging from 0.2% to 5.2% by weight, preferably 2% by weight and glycol palmitate (Lanol ​​P écaillés® notably marketed by the company SEPPIC) in a content ranging from 0.5% to 8.0% by weight, preferably 4.0% by weight; pentae-rythrityl tetra-di-t-butyl hydroxyhydrocinnamate (Tinogard TT®, notably marketed by BASF) in a content ranging from 0.02% to 0.3% by weight, preferably 0.1% by weight; glycerin / phenyl alcohol / caprylihydroxamic acid (Aromastat®, notably marketed by INOLEX) in a content ranging from 0.2% to 3.2% by weight, preferably 1% by weight; and a semio-chemical composition in a content ranging from 0.5% to 5% by weight, preferably 1% to 2% by weight. the contents being expressed in weight relative to the total weight of the W / E composition according to the invention.

[0090] In a particular embodiment of the invention, the composition has a Brookfield viscosity greater than or equal to 5500 mPa.s, in particular between 5500 mPa.s and x mPa.s, preferably 5500 mPa.s, as measured at 25°C. The viscosity within the meaning of the present invention is a Brookfield viscosity measured at room temperature (25°C), preferably after 24 hours, using a viscometer, for example a Brookfield digital viscometer (model LDVI Prime), S 63 mobile and rotation speed 6 RPM.

[0091] In a particular embodiment of the invention, the composition in the form of an oil-in-water (O / W) emulsion has a pH between 5 and 8, preferably a pH between 6 and 7. Preferably, the composition has a pH value compatible with topical application, in particular cutaneous application of the composition to the skin of an animal or human skin.

[0092] Method for preparing the composition according to the invention

[0093] The invention also relates to a first method for preparing a composition according to the invention, comprising the following steps: a) at least one gelling agent is mashed in at least one humectant; then water is added under agitation and at a temperature between 65°C and 75°C, preferably at a temperature of 70°C, so as to obtain a homogeneous aqueous phase; b) said at least one emollient agent, said at least one emulsifying agent, said semiochemical composition and optionally said at least one additive are mixed together under agitation and at a temperature between 65°C and 75°C, preferably at a temperature of 70°C, so as to obtain a homogeneous oily phase; c) the oily phase from step b) is added under agitation to the aqueous phase from step a) so as to obtain an oil-in-water (O / W) emulsion; d) optionally, the pH of the emulsion obtained in step c) is adjusted; e) optionally a fragrance is added; f) the composition is recovered in the form of an oil-in-water (O / W) emulsion obtained in step c), d) or e).

[0094] The invention also relates to a second method for preparing a composition according to the invention, comprising the following steps: a) at least one gelling agent is mashed in at least one humectant; then water is added under agitation and at a temperature between 65°C and 75°C, preferably at a temperature of 70°C, so as to obtain a homogeneous aqueous phase; b) said at least one emollient agent, said at least one emulsifying agent, said semiochemical composition, are mixed under agitation and at a temperature between 65°C and 75°C, preferably at a temperature of 70°C, so as to obtain a homogeneous oily phase; c) the oily phase from step b) is added under agitation to the aqueous phase from step a) so as to obtain an oil-in-water (O / W) emulsion; d) optionally, the pH of the emulsion obtained in step c) is adjusted; e) optionally, at least one of the said additives is added; f) the composition is recovered in the form of an oil-in-water (O / W) emulsion obtained in step c), d) or e).

[0095] Preferably, the invention relates to the first method of preparing a composition according to the invention.

[0096] The particular / preferred definitions and / or embodiments mentioned in the following paragraphs are applicable to both the first and second methods of preparing a composition according to the invention.

[0097] In the context of the invention, the term "mixing" means that before adding water in step a) of the process, said at least one gelling agent is dispersed in said at least one humectant in order to obtain a smooth and homogeneous paste. This mixing step, known to those skilled in the art, allows the particles to be separated and prevents the formation of lumps.

[0098] In a particular embodiment of the first or second process according to the invention, the mashing step a) is carried out at room temperature; and / or - the homogeneous aqueous phase obtained in step a) is kept under stirring at a temperature between 65°C and 75°C, preferably at a temperature of 70°C; and / or - the homogeneous oily phase obtained in step b) is kept under agitation at a temperature between 65 °C and 75 °C, preferably at a temperature of 70 °C; and / or - step c) is carried out by mixing the oily phase from step b) with the aqueous phase from step a) at a temperature between 65°C and 75°C, preferably at 70°C, and the emulsion is cooled to room temperature; and / or - step d) is carried out by adding a basic solution, for example a NaOH solution, in particular a 10% NaOH solution in order to increase the pH of the emulsion obtained in step c), preferably to obtain a pH between 5 and 8, preferably a pH between 6 and 7.

[0099] In a particular embodiment of the process according to the invention, the aqueous phase obtained in step a) is in the form of a homogeneous mixture.

[0100] In a particular embodiment of the process according to the invention, the oily phase obtained in step b) is in the form of a homogeneous mixture.

[0101] In the context of the invention, the term "homogeneous mixture" refers to a mixture whose different constituents cannot be distinguished with the naked eye.

[0102] In a particular embodiment of the process according to the invention, the oil-in-water (O / W) emulsion obtained in step c) is a stable and homogeneous emulsion as defined above.

[0103] In a particular embodiment of the process according to the invention, step d) is mandatory for the preparation of a composition in the form of an oil-in-water (O / W) emulsion, comprising a semiochemical composition comprising (i) 3-cyclopentyl propionic acid and 3-cyclohexyl propionic acid, preferably 50% by weight of 3-cyclopentyl propionic acid and 50% by weight of 3-cyclohexyl propionic acid (CS1).

[0104] The invention relates in particular to a method for preparing a composition according to the invention, in particular a first or second method for preparing a composition according to the invention as described above, in which the compounds of the aqueous and oily phases are as described above.

[0105] The invention also relates to the use of a composition consisting of an aqueous phase and a composition consisting of an oily phase, as described above and exemplified below, to produce a composition according to the invention comprising, as an active agent, a semiochemical composition as defined above, in the form of an oil-in-water (O / W) emulsion, in particular an oil-in-water emulsion that is stable and has a homogeneous appearance. In particular, the composition is in the form of a milk, preferably a white milk, having an opaque and thick texture (not naturally flowing out of its container). Non-therapeutic use according to the invention

[0106] According to another aspect, the invention relates to a non-therapeutic use of a composition according to the invention. According to this use, the composition according to the invention is used to obtain the expected semiochemical effect(s) of the semiochemical composition it contains.

[0107] The use of the composition according to the invention includes the topical administration, in particular cutaneous, of said composition to an animal, in particular a mammal, or to a human, or to animals treated in a group.

[0108] In a particular embodiment according to the invention, the animal is a domestic animal or a farm animal, in particular a mammal, preferably the animal is chosen from the group consisting of companion animals such as rabbits, cats, dogs, birds or from the group of farm animals such as horses or production animals such as pigs, cattle, poultry, for example chickens.

[0109] In a particular embodiment according to the invention, the composition is administered topically, in particular cutaneously, onto the skin of an animal or onto human skin.

[0110] In a particular embodiment according to the invention, the composition comprises a semiochemical composition, comprising 40% to 60% of 3-cyclopentyl propionic acid and 40% to 60% of 3-cyclohexyl propionic acid, preferably 50% of 3-cyclopentyl propionic acid and 50% of 3-cyclohexyl propionic acid; and relates to the non-therapeutic use of said composition for topical administration, in particular cutaneous administration to an animal, in particular a mammal, or to a human, or to animals treated in groups, in particular to prevent the establishment of invertebrates (blood-sucking or not) on the skin, or to prevent bites by blood-sucking invertebrates, in particular blood-sucking insects, such as mosquitoes, mites or ticks.

[0111] In a particular embodiment according to the invention, the composition comprises a semiochemical composition, in particular comprising an allomone produced by the uropygial glands of the duck, comprising 40% to 60% by weight of bis(ethyl-2 hexyl) adipate and 40% to 60% by weight of l-isopropyl-2,2-dimethyltrimethylene diisobutyrate, preferably 50% by weight of bis(ethyl-2 hexyl) adipate and 50% by weight of l-isopropyl-2,2-dimethyltrimethylene diisobutyrate; and relates to the non-therapeutic use of said composition for topical administration, in particular cutaneous to poultry such as hens, especially on the skin of poultry such as hens, in particular as a repellent allomone, in particular to prevent infestation by parasites such as the red poultry mite (Dermanyssus sp. or Omithonyssus sylviarum).Another non-therapeutic use of said composition relates to topical administration, in particular cutaneous administration to an animal, for example birds or . mammals, especially on the skin of birds or mammals, or to a human, especially on human skin, particularly to prevent infestation or bites by invertebrates, especially blood-sucking insects.

[0112] The above-mentioned use of said composition according to the invention is a non-therapeutic use, and excludes any therapeutic use performed on the animal or human body. Examples

[0113] The following examples are given purely for illustrative purposes, and should in no way be interpreted as limiting the invention. Example 1. Oil-in-water emulsions (milk)

[0114] A composition in the form of an oil-in-water (milk) emulsion according to the invention having the composition shown in the following Table 1 was prepared.

[0115] [Tables 1] Compound Name Function INCI CAS No. Weight Percentage Aqueous Phase Water AQUA 7732-18-5 q.s. Glycerol Humectant GLYCERIN 56-81-5 5.0% Xanthan Gum Gelling Agent XANTHAN GUM 11138-66-2 0.2-0.4% Oil Phase Sunflower Oil Emollient Agent HEEIANTHUS ANNUUS (SUNFLOWER) SEED OIE 8001-21-6 2.0% Montanov L Emulsifying Agent C14-22 ALCOHOLS & C12-20 ALKYL GLUCOSIDE 4.5-5.0% Montanov 14 Emulsifying Agent MYRISTYL ALCOHOL & MYRISTYL GLUCOSIDE 112-72-1 1.0% SustOleo GMS Emulsifying Agent GLYCERYL STEARATE 67701-33-1 1.0% Myritol 318 Emollient agent CAPRYLIC / CAPRI C TRI GLYCERIDE 73398-61-5 3.0% Lanol ​​Emulsifying agent GLYCOL PALMITATE 4219-49-2 4.0% Tinogard TT Antioxidant agent PENTAERYTHRITYL TETRA-DLT-BUTYL HY-DROXYHYDROCI NNAMATE 6683-19-8 0.1% Aromastat Antimicrobial Agent GLYCERIN / PHENETHYL ALCOHOL CAPRYLHYDROX AMIC ACID 56-81-5 60-12-8 7377-03-9 1.0% Fragrance Additive / / 1.0% Semiochemical Composition (CS 1 or CS2) / / 1% - 1.98% 10% NaOH Solution SODIUM HYDROXIDE 1310-73-2 0.06%-0.12%

[0116] Semiochemical composition used as an example in the formulation of Table 1 CS1: 50% by weight of 3-cyclopentyl propionic acid and 50% by weight of 3-cyclohexyl propionic acid; CS2: 50% by weight of bis(ethyl-2 hexyl) adipate and 50% by weight of 1-isopropyl-2,2-dimethyltrimethylene diisobutyrate.

[0117] Example 2. Process for preparing the oil-in-water (milk) emulsion according to Example 1

[0118] The oil-in-water (milk) emulsion according to Example 1 was prepared according to the following protocol: STEP 1: Preparation of the dough / aqueous phase 1. In a container suitable for receiving the final volume of the aqueous phase, the glycerin and xanthan gum were weighed and added. The mixture was shaken at room temperature. 2. Once the mashing was complete, all the water was added. 3. After homogenization of the aqueous phase (obtaining a homogeneous mixture), the aqueous phase was maintained at 70°C and under agitation until step 3. STEP 2: Preparation of the oil phase 4. In another container suitable for receiving the final volume of the oil phase, the components of the oil phase were weighed and added, namely Sunflower Oil, Montanov L, Montanov 14, SustOleo GMS, Myritol 318, Lanol ​​P flakes, Tinogard TT, Aromastat and the semiochemical composition. 5. Once all the compounds were added, the mixture was stirred and heated to 70°C until a homogeneous mixture was obtained. STEP 3: Formation of the oil-in-water emulsion 6. When the two phases (aqueous and oily) were perfectly homogeneous, one The oil phase at 70°C was added to the aqueous phase at 70°C. Proper agitation of the emulsion was ensured throughout this step. The emulsion was then cooled to room temperature after homogenization. STEP 4: pH adjustment only for the CS1 composition mentioned above 7. In order to increase the pH, a pH adjustment step was carried out by adding a 10% NaOH solution until a pH between 6 and 7 was obtained. STEP 5: Perfume 8. Addition of any fragrance under agitation at room temperature STEP 6: Recovery of the oil-in-water (O / W) emulsion The final emulsion obtained in the form of a milk was white, opaque and thick.

[0119] Example 3. Organoleptic measurements of oil-in-water (milk) emulsions according to example 1

[0120] Four criteria (appearance, color, odor, texture) were selected for the measurements organoleptic. Appearance: Thick milk Color: White Odor: Characteristic odor Texture: light (fluid) texture and rich (cream) texture

[0121] Example 4. pH measurements of the oil-in-water emulsion (milk) according to example 1

[0122] The pH measurements were carried out using a LE 438 IP 67 electrode marketed by Mettler Toledo®. This is a 2-in-1 glass pH electrode with integrated temperature sensor and liquid electrolyte for rapid laboratory measurements; for aqueous samples, such as acids, bases, etc.

[0123] The specifications of this electrode are mentioned in the following Table 2.

[0124] [Tables2] Measuring range pH 0 - 14 Zero point 7.00 ± 0.25 Temperature range 0 - 80 °C Temperature probe NTC 30 kQ Membrane resistance (25 °C) < 250 MQ Reference electrolyte 3 mol / L KCl solution saturated with AgCl Reference system Ag / AgCl Reference diaphragm Gel

[0125] Before any measurement was taken, the pH meter used was calibrated. Indeed, the nature of the semiochemical composition can affect the pH of the emulsion because some semiochemicals have an acidic pH. For topical application, particularly cutaneous application, it is therefore necessary to measure the pH of each emulsion obtained and, if necessary, adjust the pH to obtain a pH between 5 and 8, preferably between 6 and 7. A pH measurement was carried out after the emulsion was obtained, and is reported below: MILK with CS1: 4.0 < pH < 5.0 MILK with CS2: 5.5 < pH < 7.5 In order to get as close as possible to the pH of animal or human skin, and to avoid causing skin irritation, a pH adjustment was made for the MILK formulation with CS1. Following this adjustment, a new pH measurement was taken and is reported below: MILK with CS1: 6.0 < pH < 7.0 For the formulation corresponding to MILK with CS2, no pH adjustment step was performed.

[0126] Example 5. Measurement of the viscosity of the oil-in-water emulsion (milk) according to example 1

[0127] Viscosity is the resistance of a fluid to the sliding of one layer relative to another. For each formulation, the viscosity must be checked after each batch. Viscosity is influenced by several factors, including temperature, the measuring instrument used, the measurement speed, and the time of measurement relative to the batch (measurements at T0 and T+24h, T+48h). Viscosity measurement should be performed when the solution is at room temperature, preferably at T+24h. The measurement of the viscosity of the oil-in-water emulsion according to example 1 was carried out using the Brookfield digital viscometer (model DV-I Prime), mobile S 63 and at a rotation speed of 6 RPM. The Brookfield DV-I Prime viscometer measures the viscosity of fluids at a given velocity gradient. The operating principle involves rotating a spindle (which is immersed in the liquid being tested) by means of a calibrated spring. The measurement range (in centipoise or millipascal-seconds) is determined by the spindle's rotational speed, size and shape, the section in which the spindle is rotating, and the full-scale torque of the calibrated spring. The specifications of the Brookfield DV-I Prime viscometer are reported in the following Table 3.

[0128] [Table 3]: Speeds (rpm) 0.0; 0.3; 0.6; 1.5; 3; 6; 12; 30; 60; 0.5; 1; 2; 2.5; 4; 5; 10; 20; 50; 100 Viscosity range (cP) 15 - 2,000,000 Operating environment Temperature range 0°C to 40°C (32°F to 104°F) 20% to 80% RH: non-condensing Analog torque output 0-1 Vcc (torque 0 to 100%) Viscosity measurement accuracy ± 1°C: - of full scale Viscosity measurement reproducibility 0.2% of full scale Used mobiles S61; S62; S63; S64

[0129] Following these measurements, all the oil-in-water (milk) emulsions according to example 1 had a viscosity > 5500 cP or mPa.s. References

[0130] - Silverstein, RM, 1977. "Complexity, diversity and specificity of behavior- modifying Chemicals; examples from Coleoptera and Hymenoptera," Chemical Control of Insect Behavior:Theory and Application. Publishers HH Shorey & JJMcKelvey pp.231-251 New York: Plénum Press); - Wyatt T.D., 2003 "Pheromones and Animal Behavior. Communication by smell and taste, pp.1-4 New York: Cambridge University Press.

Claims

Demands

1. Composition in the form of an oil-in-water (O / W) emulsion comprising: a) an aqueous phase comprising water, at least one humectant selected from polyols and sugars, and at least one gelling agent selected from polysaccharides, b) an oily phase comprising at least one emollient, at least one emulsifying agent, and a semiochemical composition, wherein said semiochemical composition comprises (i) 3-cyclopentyl propionic acid and 3-cyclohexyl propionic acid, or (ii) bis(ethyl-2-hexyl) adipate and l-isopropyl-2,2-dimethyltrimethylene diisobutyrate.

2. Composition in the form of an oil-in-water (O / W) emulsion according to claim 1, characterized in that said semiochemical composition comprises (i) 40% to 60% by weight, preferably 50% by weight of 3-cyclopentyl propionic acid, and 40% to 60% by weight, preferably 50% by weight of 3-cyclohexyl propionic acid, or (ii) 40% to 60% by weight, preferably 50% by weight of bis(ethyl-2 hexyl) adipate, and 40% to 60% by weight, preferably 50% by weight of l-isopropyl-2,2-dimethyltrimethylene diisobutyrate, the total sum of the compounds present in said semiochemical composition being equal to 100%.

3. Composition in the form of an oil-in-water (O / W) emulsion according to claim 1 or 2, characterized in that said at least one humectant is selected from polyols from the group consisting of glycerol, propylene glycol, polyethylene glycols (PEG), xylitol, isomalt, maltitol, mannitol, polydextrose, sorbitol, isomaltitol, lactitol, and mixtures thereof; and / or said at least one humectant is selected from sugars from the group consisting of fructose, glucose, lactose; preferably said at least one humectant is glycerol.

4. Composition in the form of an oil-in-water (O / W) emulsion according to any one of claims 1 to 3, characterized in that said at least one humectant is present in a content of 4% to 12% by weight, preferably 4% to 6% by weight, relative to the total weight of the composition.

5. Composition in the form of an oil-in-water (O / W) emulsion according to any one of claims 1 to 4, characterized in that the polysaccharides are selected from the group consisting of xanthan gum, guar gum, cellulose, cellulose derivatives, maltodextrin, maltodextrin derivatives, and mixtures thereof, preferably xanthan gum.

6. Composition in the form of an oil-in-water (O / W) emulsion according to any one of claims 1 to 5, characterized in that the polysaccharides are present in a content ranging from 0.05% to 1% by weight, preferably from 0.1% to 0.3% by weight, relative to the total weight of the composition.

7. Composition in the form of an oil-in-water (O / W) emulsion according to any one of claims 1 to 6, characterized in that it comprises from 60% to 95% by weight of water, preferably from 70% to 80% by weight of water, relative to the total weight of the composition, and / or in that it comprises from 0.5% to 5% by weight, preferably from 1% to 2% by weight of said semiochemical composition, relative to the total weight of the composition.

8. Composition in the form of an oil-in-water (O / W) emulsion according to any one of claims 1 to 7, characterized in that said at least one emollient agent is selected from the group consisting of hydrogenated or non-hydrogenated vegetable oils, in particular vegetable oils comprising triglycerides of unsaturated fatty acids, silicone oils, mineral oils and waxes, fatty alcohols, fatty acids and esters of fatty acids, glyceride derivatives, glycerol derivatives, and mixtures thereof, preferably said at least one emollient agent is a mixture of emollient agents consisting of glyceride derivatives and vegetable oils comprising triglycerides of unsaturated fatty acids.

9. Composition in the form of an oil-in-water (O / W) emulsion according to any one of claims 1 to 8, characterized in that said at least one emollient agent is present in a content of 1% to 19% by weight, preferably 4% to 6% by weight, relative to the total weight of the composition.

10. A composition in the form of an oil-in-water (O / W) emulsion according to any one of claims 1 to 9, characterized in that said at least one emulsifying agent is selected from alkyl polyglucosides, mixtures of at least one alkyl polyglucoside and at least one fatty alcohol, fatty acid esters, or alcohol esters and of fatty acid.

11. Composition in the form of an oil-in-water (O / W) emulsion according to any one of claims 1 to 10, characterized in that said at least one emulsifying agent is present in a content of 2% to 30% by weight, preferably 10% to 12% by weight, relative to the total weight of the composition.

12. Composition in the form of an oil-in-water (O / W) emulsion according to any one of claims 1 to 11, characterized in that the oil phase further comprises at least one additive selected from the group consisting of a preservative, in particular an antimicrobial agent or an antioxidant agent, a perfume, a masking agent, and mixtures thereof.

13. Composition in the form of an oil-in-water (O / W) emulsion according to any one of claims 1 to 12, characterized in that it is in the form of a milk.

14. A composition in the form of an oil-in-water (O / W) emulsion according to any one of claims 1 to 13, characterized in that it comprises: a) an aqueous phase comprising water, glycerol, and xanthan gum; b) an oily phase comprising at least one C12-C20 alkyl polyglucoside and at least one C14-C22 fatty alcohol, a mixture of myristic alcohol and myristyl glucoside, caprylic / capric acid triglycerides, sunflower oil, glyceryl stearate, glycol palmitate, pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate, glycerin / phenyl alcohol / caprylhydroxamic acid, and a semiochemical composition, the semiochemical composition being present in the composition in the form of an emulsion. oil-in-water in a content of 0.5% to 5% by weight, preferably 1% to 2% by weight, relative to the total weight of the composition.

15. A method for preparing a composition in the form of an oil-in-water (O / W) emulsion according to any one of claims 1 to 14, comprising the following steps: a) said at least one gelling agent is mashed in said at least one humectant; then water is added under agitation and at a temperature between 65°C and 75°C, preferably at a temperature of 70°C, so as to obtain a homogeneous aqueous phase; b) said at least one emollient agent, said at least one emulsifying agent, said semiochemical composition and optionally said at least one additive are mixed together under agitation and at a temperature between 65°C and 75°C, preferably at a temperature of 70°C, so as to obtain a homogeneous oily phase; c) the oily phase from step b) is added under agitation to the aqueous phase from step a) so as to obtain an oil-in-water (O / W) emulsion; d) optionally, the pH of the emulsion obtained in step c) is adjusted; e) optionally, a fragrance is added; f) the composition is recovered in the form of an oil-in-water (O / W) emulsion obtained in step c), d) or e).

16. The method according to claim 15, characterized in that: - the mashing step a) is carried out at room temperature; and / or - the homogeneous aqueous phase obtained in step a) is kept under stirring at a temperature between 65°C and 75°C, preferably at a temperature of 70°C; and / or - the homogeneous oily phase obtained in step b) is kept under agitation at a temperature between 65°C and 75°C, preferably at a temperature of 70°C; and / or - step c) is carried out by mixing the oily phase from step b) with the aqueous phase from step a) at a temperature between 65°C and 75°C, preferably at 70°C, and the emulsion is cooled to room temperature; and / or - step d) is carried out by adding a basic solution, for example a NaOH solution.

17. Non-therapeutic use of a composition in the form of an oil-in-water (O / W) emulsion according to any one of claims 1 to 14, for topical administration, in particular cutaneous administration to an animal, in particular a mammal, or to a human, in particular to prevent the establishment of invertebrates (blood-sucking or non-blood-sucking) on ​​the skin, or to prevent bites by blood-sucking invertebrates, in particular blood-sucking insects, such as mosquitoes, mites or ticks; or to prevent infestation by parasites such as the red poultry mite (Dermanyssus sp. or Omithonyssus sylviarum).