Oil-in-water emulsion comprising a semiochemical composition, suitable for administration in the form of a mist

Abstract

The invention relates to the field of semiochemical products, and describes in particular a composition in the form of an oil-in-water emulsion comprising an aqueous phase, and an oily phase comprising a semiochemical composition, in particular suitable for administration in the form of a mist, as well as its preparation process. The invention also relates to the non-therapeutic use of the composition according to the invention for administration, in particular by spraying using a mist sprayer, onto the skin of an animal or a human, or onto the skin of farm animals treated in groups, or onto an element of the environment such as textiles and / or objects and / or walls, or by spraying into the air, in particular near the nose of an animal or a human.

Description

Title of the invention: Oil-in-water emulsion comprising a semiochemical composition, suitable for administration in the form of a mist Technical field of the invention

[0001] The invention relates to the field of semiochemical products, and describes in particular a composition in the form of an oil-in-water emulsion comprising an aqueous phase, and an oily phase comprising a semiochemical composition, in particular suitable for administration in the form of a mist, as well as its preparation process. The invention also relates to the non-therapeutic use of the composition according to the invention for administration, in particular by spraying using a mist sprayer, onto the skin of an animal or a human, or onto the skin of farm animals treated in groups, or onto an element of the environment such as textiles and / or objects and / or walls, or by spraying into the air, in particular near the nose of an animal or a human. State of the prior art

[0002] The semiochemicals according to the invention correspond to mixtures of several chemical compounds, described for the first time in particular by Silverstein, RM (1977). Semiochemicals are chemical substances emitted by a plant or an animal which provoke a non-therapeutic behavioral or physiological reaction in another organism. When the semiochemical product affects an individual of the same species (an "intraspecific" semiochemical product), it is called a pheromone (Wyatt TD, 2003). There are several types of pheromones allowing different types of behavioral interactions or communication, for example appeasing pheromones, sex pheromones, territorial marking pheromones and alert pheromones. When the semiochemical product affects an individual of a different species (an "interspecific" semiochemical product), it is called an allelochemical substance.Among allelochemicals, an allomone is an allelochemical that triggers a reaction in the target species, this reaction being favorable to the species that releases the allomone (the opposite is a kairomone).

[0003] Since 1995, specialties whose active ingredients are semiochemical agents have been placed on the market. Some of their uses require the product to be deposited on the animal's skin, for example to achieve the desired effects on an animal in an open environment or to protect it against pests such as parasites or biting insects, or on human skin. Physicochemical constraints of semiochemical components, and in particular their volatility and insolubility in water, have led to the use of excipients such as ethoxydiglycol in commercial specialties. The use of this type of excipient is today increasingly limited by current regulations, but also by the general public, which tends to reject them due to their synthesis methods and their potential direct and environmental toxicity. It has therefore become necessary to develop aqueous formulations of semiochemical compounds. Presentation of the invention

[0004] The invention aims to develop a composition based on semiochemical products (also called compounds, active ingredients or agents) in a new galenic form, preferably non-toxic and environmentally friendly, in particular in the form of an oil-in-water (O / W) emulsion, preferably in the form of a stable and homogeneous oil-in-water (O / W) emulsion, for administration, in particular by spraying using a mist sprayer, onto the skin of an animal, in particular a mammal, or a human, or onto the skin of farm animals treated in groups, or onto an element of the environment such as textiles and / or objects and / or walls, or by spraying into the air, in particular near the nose of an animal or a human, in particular to reduce and / or avoid obtaining a wetting effect or stains; or to reach the vomeronasal and olfactory mucosa more quickly.Another objective of the invention is to develop a composition based on semiochemical products that is positively evaluated in acceptability tests by target animals. Summary of the invention

[0005] The invention is defined by the independent claims. The dependent claims define particular or preferred embodiments of the invention.

[0006] According to a first aspect, the invention relates to a composition in the form of an oil-in-water (O / W) emulsion (called O / W composition or composition according to the invention), suitable in particular for the release of semiochemical compounds, comprising: (a) an aqueous phase comprising water and at least one humectant chosen from polyols and sugars, b) an oily phase comprising at least one emollient agent, at least one emulsifying agent, and a semiochemical composition, wherein said semiochemical composition comprises: - methyl oleate and methyl palmitate, preferably methyl linoleate, methyl oleate and methyl palmitate; or - 3-cyclopentyl propionic acid and 3-cyclohexyl propionic acid; or - bis(2-ethylhexyl) adipate and l-isopropyl-2,2-dimethyltrimethylene diisobutyrate.

[0007] According to a second aspect, the invention relates to a process for preparing a composition in the form of an oil-in-water (O / W) emulsion according to the invention, comprising the following steps: a) said at least one gelling agent is pasted into said at least one humectant; then water is added with stirring and at a temperature between 65°C and 75°C, preferably at a temperature of 70°C, so as to obtain a homogeneous aqueous phase; b) mixing said at least one emollient agent, said at least one emulsifying agent, said semiochemical composition and optionally said at least one additive, with stirring and at a temperature between 65°C and 75°C, preferably at a temperature of 70°C, so as to obtain a homogeneous oily phase; c) the oily phase from step b) is added with stirring to the aqueous phase from step a) so as to obtain an oil-in-water (O / W) emulsion; d) optionally the pH of the emulsion obtained in step c) is adjusted; e) optionally add a perfume; f) the composition is recovered in the form of an oil-in-water (O / W) emulsion obtained in step c), d) or e).

[0008] According to a third aspect, the invention relates to the non-therapeutic use of a composition according to the invention for administration, in particular by spraying using a mist sprayer, onto the skin of an animal or a human, or onto the skin of farm animals treated in a group, or onto an element of the environment such as textiles and / or objects and / or walls, or by spraying into the air, in particular near the nose of an animal or a human. Detailed description of the invention

[0009] The invention is now described in more detail and in a non-limiting manner in the following description. Unless otherwise indicated, all percentages relating to quantities are mass percentages. Any reference to ranges of values ​​in the description and / or the claims implies, unless otherwise stated, that the limits of the ranges are included.

[0010] The invention relates to a composition in the form of an oil-in-water (O / W) emulsion comprising: (a) an aqueous phase comprising water and at least one humectant chosen from polyols and sugars, b) an oily phase comprising at least one emollient agent, at least one emulsifying agent, and a semiochemical composition, wherein said semiochemical composition comprises: - methyl oleate and methyl palmitate, preferably methyl linoleate, methyl oleate and methyl palmitate; or - 3-cyclopentyl propionic acid and 3-cyclohexyl propionic acid; or - bis(2-ethylhexyl) adipate and diisobutyrate l-isopropyl-2,2-dimethyltrimethylene.

[0011] In a particular embodiment of the invention, said semiochemical composition comprises: - methyl oleate, methyl linoleate, methyl behenate, methyl palmitate, methyl myristate and methyl laurate; or - methyl linoleate, methyl oleate, methyl palmitate, methyl myristate, methyl laurate and methyl decanoate; or - methyl linoleate, methyl oleate, methyl palmitate, methyl stearate, methyl myristate, methyl pentadecanoate and methyl laurate; or - methyl linoleate, methyl oleate, methyl palmitate, 2-(2-butoxyethoxy)ethanol, dimethyl glutarate, dimethyl adipate, dimethyl succinate and dodecane; or - methyl oleate, methyl palmitate, methyl linoleate, methyl stearate, methyl myristate and methyl pentadecanoate; or - methyl oleate, methyl linoleate, methyl palmitate, squalene, methyl myristate and methyl pentadecanoate; or - methyl oleate, methyl palmitate, dimethyl pimelate and dimethyl azelate; or - methyl laurate, methyl myristate, methyl palmitate, methyl stearate, methyl oleate, methyl linoleate, dimethyl pimelate and dimethyl azelate; or - 3-cyclopentyl propionic acid and 3-cyclohexyl propionic acid; or - bis(2-ethylhexyl) adipate and diisobutyrate l-isopropyl-2,2-dimethyltrimethylene; or - methyl oleate, methyl palmitate, methyl linoleate, dioxolane, methyl laurate and methyl myristate.

[0012] In a preferred embodiment of the invention, said semiochemical composition comprises: - from 25% to 35% methyl oleate, from 20% to 25% methyl linoleate, from 20% to 25% methyl behenate, from 20% to 25% methyl palmitate, from 3% to 6% methyl myristate and from 2% to 4% methyl laurate; or - 30% to 40% methyl linoleate, 25% to 35% methyl oleate, 15% 25% methyl palmitate, 5% to 9% methyl myristate, 5% to 7% methyl laurate and 1% to 3% methyl decanoate; or - from 25% to 35% methyl linoleate, from 25% to 35% methyl oleate, from 15% to 25% methyl palmitate, from 10% to 15% methyl stearate, from 2% to 7% methyl myristate, from 2% to 6% methyl pentadecanoate and from 1% to 3% methyl laurate; or - from 30% to 40% of methyl linoleate, from 25% to 35% of methyl oleate, from 15% to 25% of methyl palmitate, from 5% to 15% of 2-(2-butoxyethoxy)ethanol, from 2% to 6% of dimethyl glutarate, from 1% to 3% of dimethyl adipate, from 1% to 3% of dimethyl succinate and from 1% to 3% of dodecane; or - from 25% to 35% methyl oleate, from 25% to 35% methyl palmitate, from 25% to 35% methyl linoleate, from 3% to 7% methyl stearate, from 3% to 5% methyl myristate and from 0.5% to 2% methyl pentadecanoate; or - from 30% to 40% methyl oleate, from 20% to 26% methyl linoleate, from 20% to 26% methyl palmitate, from 6% to 10% squalene, from 2% to 6% methyl myristate and from 3% to 5% methyl pentadecanoate; or - from 62% to 70% of methyl oleate, from 12% to 16% of methyl palmitate, from 7% to 13% of dimethyl pimelate and from 6% to 11% of dimethyl azelate; or - from 2% to 6% of methyl laurate, from 2% to 6% of methyl myristate, from 11% to 15% of methyl palmitate, from 2% to 6% of methyl stearate, from 42% to 50% of methyl oleate, from 4% to 8% of methyl linoleate, from 7% to 13% of dimethyl pimelate and from 6% to 11% of dimethyl azelate; or - from 40% to 60% of 3-cyclopentyl propionic acid and from 40% to 60% of 3-cyclohexyl propionic acid; or - from 40% to 60% of bis(2-ethylhexyl) adipate and from 40% to 60% of l-isopropyl-2,2-dimethyltrimethylene diisobutyrate, - from 35% to 45% by weight of methyl oleate, from 20% to 30% by weight of methyl palmitate, from 20% to 30% by weight of methyl linoleate, from 2% to 7% by weight of dioxolane, from 1% to 5% by weight of methyl laurate and from 1% to 4% by weight of methyl myristate; the total sum of the compounds present in said semiochemical composition being equal to 100%. Galenic and method of administration

[0013] The composition according to the invention is in the form of an oil-in-water (O / W) emulsion, in particular an oil-in-water emulsion which is stable and has a homogeneous appearance, in particular to the naked eye.

[0014] In the context of the invention, the term "emulsion" refers to a mixture of two immiscible liquid substances, such as oil and water. In an emulsion oil-in-water (O / W), the oil is dispersed in water in the form of droplets, especially small droplets.

[0015] In the context of the invention, the term "stable emulsion" refers to an emulsion which does not show signs of instability (phase separation, increase in droplet size, etc.), in particular an emulsion which does not release water or oil and which remains in its initial form over time and under different temperature conditions, for example during 3 months of storage at a temperature between 5°C and 40°C.

[0016] In the context of the invention, the term "homogeneous emulsion" refers to an emulsion whose surface is smooth and uniform to the naked eye.

[0017] In particular, the composition may be administered using a spray device, in particular using a mist sprayer, in the form of a fluid, opalescent, transparent or translucent mixture, in particular in the form of a mist.

[0018] In the context of the invention, the term "mist" refers to an aqueous dispersion in droplets comparable to a cloud of droplets or light fog.

[0019] In the context of the invention, the term "fluid mixture" refers to a mixture of low viscosity, having the capacity to flow under its own weight, unlike a solid composition.

[0020] In the context of the invention, the term "opalescent" refers to a milky, iridescent color, a reflection reminiscent of opal.

[0021] In the context of the invention, the term "transparent" means that the mixture lets light pass through and allows objects behind to appear clearly.

[0022] In the context of the invention, the term "translucent" means that the mixture lets light through but does not allow objects behind it to appear clearly, these objects remaining blurred.

[0023] The H / W composition according to the invention can be applied to small and / or large body areas (for example, the skin of an animal or human skin) and / or material areas (for example, to an element of the environment such as clothing and / or objects and / or walls).

[0024] Preferably, the H / W composition according to the invention is administered in the form of a mist using a sprayer.

[0025] Non-limiting examples of misters are well known to those skilled in the art.

[0026] Preferably, the mist, in particular the droplets of this mist, is opaque. lescent, transparent or translucent, preferably transparent. Aqueous phase

[0027] The composition according to the invention comprises an aqueous phase, in particular a continuous aqueous phase (also called external phase).

[0028] The aqueous phase of the composition according to the invention comprises water, preferably demineralized water or purified water, and optionally one or more water-miscible or at least partially water-miscible compounds, for example a skin-conditioning agent such as ALOE VERA, a hydrosol, urea, an antistatic agent.

[0029] In the context of the invention, the term "skin conditioning agent" refers to an agent for maintaining the skin in good condition, e.g., healthy in appearance.

[0030] In the context of the invention, the term "antistatic agent" refers to an agent that reduces static electricity by neutralizing the electrical charge on a surface.

[0031] In a particular embodiment of the invention, the composition according to the invention comprises from 60% to 95% by weight of water, preferably from 77% to 87% by weight of water, relative to the total weight of the composition.

[0032] In a preferred embodiment of the invention, the composition according to the invention comprises from 62% to 91% by weight of water, preferably from 77% to 87% by weight of water, even more preferably 82.5% or 83.9% or 85.7% by weight of water, relative to the total weight of the composition.

[0033] The aqueous phase of the composition according to the invention may comprise water and at least one humectant chosen from polyols and sugars. Humectant

[0034] According to a particular embodiment, the aqueous phase of the composition according to the invention further comprises at least one humectant chosen from polyols and sugars. In particular, the aqueous phase of the composition according to the invention further comprises a single humectant chosen from polyols or sugars, preferably polyols. Said at least one humectant is in particular soluble in the aqueous phase.

[0035] In the context of the invention, the term “humectant” (also called moisturizing agent) refers to a compound or mixture of compounds capable of retaining water thanks to their hygroscopic power.

[0036] In the context of the invention, the term “polyol” refers to any organic compound comprising at least two free hydroxyl (-OH) groups such as glycols.

[0037] In the context of the invention, the term "sugar" refers to simple carbohydrates, in particular any organic molecule consisting of one ose (monosaccharide) or two oses (disaccharide).

[0038] In a particular embodiment of the invention, said at least one humectant is chosen from polyols selected from the group consisting of glycerol (also called glycerin), propylene glycol, polyethylene glycols (PEG), xylitol, isomalt, maltitol, mannitol, polydextrose, sorbitol, isomaltitol, lactitol, and mixtures thereof; and / or said at least one humectant is chosen from sugars selected from the group consisting of fructose, glucose, lactose, and their mixtures.

[0039] In a preferred embodiment of the invention, said at least one humectant is a polyol, in particular glycerol.

[0040] Said at least one humectant, i.e., one or more humectants, preferably a humectant, may be present in the composition in a content ranging from 4% to 12% or 4.5% to 12% by weight, preferably from 4% to 6% by weight, relative to the total weight of the composition.

[0041] Preferably, said at least one humectant is glycerol and is present in the composition in a content ranging from 4.5% to 12% by weight, preferably 5% by weight, relative to the total weight of the composition.

[0042] In a particular embodiment of the invention, the aqueous phase of the composition comprises water in a content of 62% to 91% by weight, preferably 77% to 87% by weight, even more preferably 82.5% or 83.9% or 85.7% by weight, and glycerol in a content ranging from 4.5% to 12% by weight, preferably 5% by weight, all of the percentages being given relative to the total weight of the composition. Oily phase

[0043] The composition according to the invention comprises an oily phase, in particular a dispersed oily phase (also called discontinuous or internal phase).

[0044] The oily phase of the composition according to the invention may comprise at least one emollient agent, at least one emulsifying agent, and a semiochemical composition. In particular, said at least one emollient agent, said at least one emulsifying agent, and said semiochemical composition are in particular soluble in the oily phase.

[0045] The oily phase may be present in a content ranging from 3% to 45% by weight, preferably from 10% to 25% by weight, relative to the total weight of the composition. Emollient agent

[0046] According to a particular embodiment, the oily phase of the composition according to the invention further comprises at least one emollient agent. In particular, the oily phase of the composition according to the invention further comprises a single emollient agent. Said at least one emollient agent is in particular soluble in the oily phase.

[0047] In the context of the invention, the term "emollient agent" refers to an agent for softening and making the skin supple during topical administration, in particular cutaneous administration, of the composition according to the invention.

[0048] In a particular embodiment of the invention, said at least one emollient agent is chosen from the group consisting of hydrogenated vegetable oils (vegetable oils comprising triglycerides of unsaturated fatty acids, e.g. hydrogenated olive oil, hydrogenated rapeseed oil, hydrogenated sunflower oil, hydrogenated sesame oil, hydrogenated linseed oil, hydrogenated hemp oil, hydrogenated walnut oil, hydrogenated hazelnut oil, hydrogenated coconut oil, hydrogenated argan oil, hydrogenated jojoba oil, hydrogenated sweet almond oil, hydrogenated shea butter, hydrogenated castor oil, hydrogenated avocado oil, hydrogenated apricot kernel oil, hydrogenated macadamia oil, ...), silicone oils (e.g. dimethicone, ...), mineral oils and waxes (e.g., Paraffin, ...), fatty alcohols (e.g., alcohol ara-chidic, batyl alcohol, behenyl alcohol, C12-C13 alcohols, cetearyl alcohol, cetyl alcohol, coconut alcohol, isocetyl alcohol, octyldodecanol, palm alcohol, ...), fatty acids and fatty acid esters (e.g., batyl stearate, cetearyl behenate, cetearyl isononanoate, cetyl esters, coconut acid, ethyl linoleate, ethyl linolenate, ethyl olivate, ethylhexyl cocoate, ethylhexyl myristate, glyceryl caprylate, glyceryl laurate / oleate, glyceryl ricinoleate, isocetyl salicylate, isostearyl alcohol, linoleic acid, linolenic acid, oleic acid, palm kernel acid, palmitic acid, wheat germ acid, ...), glyceride derivatives (e.g., capric and caprylic acid triglycerides, cocoglycerides, palm glycerides, ...) and glycerol derivatives (e.g., glyceryl trioctanoate: Tricaprylin, Glycerol Tristearate: Tristearin...), preferably glyceride derivatives such as fatty acid triglycerides.

[0049] Said at least one emollient agent, i.e., one or more emollient agent(s), is / are present in a content ranging from 0.5% to 8% by weight, preferably from 1% to 3% by weight, relative to the total weight of the composition.

[0050] Preferably, said at least one emollient agent is a glyceride derivative, in particular a fatty acid triglyceride, in particular a caprylic acid and capric acid triglyceride such as that marketed in particular by the company BASF under the name Myritol 318®, and is present in the composition in a content ranging from 0.5% to 8% by weight, preferably 2% by weight, relative to the total weight of the composition.

[0051] In a particular embodiment of the invention, the aqueous phase of the composition comprises water in a content of 62% to 91% by weight, preferably 77% to 87% by weight, even more preferably 82.5% or 83.9% or 85.7% by weight, and glycerol in a content ranging from 4.5% to 12% by weight, preferably 5% by weight, and the oily phase of the composition comprises a caprylic acid and capric acid triglyceride such as Myritol 318® in a content ranging from 0.5% to 8% by weight, preferably 2% by weight, all percentages being given relative to the total weight of the composition. Emulsifying agent

[0052] The oily phase of the composition according to the invention further comprises at least one emulsifying agent, preferably one or more emulsifying agent(s). Said at least one emulsifying agent is in particular soluble in the oily phase.

[0053] In the context of the invention, the term "emulsifying agent" (also called emulsifying agent) refers to a small molecule composed of a hydrophilic head soluble in the aqueous phase and a lipophilic tail having an affinity for the oily phase. Said at least one emulsifying agent allows the formation of an interfacial film around the droplets located in the dispersed phase, thus forming the emulsion and providing stability to this formed emulsion.

[0054] Said at least one emulsifying agent may be chosen from non-ionic or ionic (anionic, cationic) surfactants, preferably non-ionic surfactants.

[0055] In the context of the invention, the term "surfactant" refers to a compound making it possible to reduce the surface tension and promoting a uniform distribution of the composition according to the invention during its use.

[0056] In a particular embodiment of the invention, said at least one emulsifying agent is an ionic surfactant, preferably an anionic surfactant chosen from sulfated castor oil, sodium dodecyl sulfate (SDS), sodium coco sulfate (INCI Name: Sodium coco sulfate (SCS)), sodium cocoyl isethionate (INCI Name: Sodium cocoyl isethionate (SCI)), sodium lauryl sulfoacetate (INCI Name: Sodium lauryl sulfoacetate (SLSA)), sodium laureth sulfate (INCI Name: Sodium laureth sulfate (SLES)) and sodium lauroyl sarcosinate (INCI Name: Sodium Lauroyl Sarcosinate), or a cationic surfactant chosen from cetearyl alcohol (INCI Name: Cetearyl Alcohol), behentrimonium methosulfate (INCI Name: Be-hentrimonium Methosulfate (BTMS)), Brassica Alcohol (and) Brassicyl Valinate Esylate (INCI Name: Brassica Alcohol (and) Brassicyl Valinate Esylate), Benzalkonium Chlorides (BAC),didecyldimethylammonium chlorides (DDAC), brassicamidopropyl dimethylamine (INCI Name: Brassicamidopropyl dimethylamine), Polyquaternium-7, Polyquaternium-10, Polyquatemium-22 and Poly-quatemium-37.

[0057] In a preferred embodiment of the invention, said at least one emulsifying agent is a non-ionic surfactant, preferably a non-ionic surfactant having an HLB of between 8 and 20 at 25°C, and is in particular chosen from fatty acid esters of polyoxyethylene sorbitan, fatty acid esters of polyols or ethoxylated vegetable oils, preferably hydrogenated and ethoxylated.

[0058] Examples of polyoxyethylene sorbitan fatty acid esters (also called ethoxylated sorbitan, sorbitan esters) include, but are not limited to, C8 fatty acid esters -C24, preferably C16-C22 and polyoxyethylene sorbitan which may contain from 1 to 150 oxyethylenated groups, such as polysorbate 20, in particular marketed under the name Tween 20® by the company CRODA, polysorbate 21, in particular marketed under the name Tween 21® by the company CRODA, polysorbate 40, in particular marketed under the name Tween 40® by the company CRODA, polysorbate 60, in particular marketed under the name Tween 60® by the company CRODA, polysorbate 61, in particular marketed under the name Tween 61® by the company CRODA, polysorbate 65, in particular marketed under the name Tween 65® by the company CRODA, polysorbate 80, in particular marketed under the name Tween 80® by the company CRODA, polysorbate 81, in particular marketed under the name Tween 81® by the company CRODA and polysorbate 85, notably marketed under the name Tween 85® by the company CRODA,preferably polysorbate 80 or polysorbate 20. ,

[0059] Examples of fatty acid esters of polyols, in particular polyglycerols, include in particular polyglyceryl-3 beeswax, polyglyceryl-6 distearate, polyglyceryl-4 caprate, or polyglyceryl-3 distearate, in particular marketed by the company BASF under the name Cremophor GS 32®, preferably Cremophor GS 32®.

[0060] Examples of ethoxylated vegetable oils, preferably hydrogenated and ethoxylated vegetable oils, include in particular ethoxylated and hydrogenated castor oil, in particular PEG-35 or PEG-40 hydrogenated castor oil, preferably PEG-40 hydrogenated castor oil marketed in particular by the company BASF under the name Eumulgin CO 40®, preferably Eumulgin CO 40®.

[0061] In a particular embodiment of the invention, said at least one emulsifying agent, i.e., one or more emulsifying agent(s), is / are present in the composition in a content ranging from 1% to 25% by weight, preferably from 5% to 7% by weight, relative to the total weight of the composition.

[0062] In a preferred embodiment of the invention, the composition according to the invention comprises several emulsifying agents, in particular a mixture of emulsifying agents consisting of fatty acid esters of polyoxyethylene sorbitan, fatty acid esters of polyols, and ethoxylated vegetable oils, preferably hydrogenated and ethoxylated.

[0063] Preferably, said emulsifying agents are polyglyceryl-3 distearate, notably marketed by the company BASF under the name Cremophor GS 32®, PEG-40 hydrogenated castor oil, notably marketed by the company BASF under the name Eumulgin CO 40®, esters of fatty acid and polyoxyethylene sorbitan such as polysorbate 80, notably marketed under the name Tween 80® by the company CRODA or polysorbate 20, notably marketed by the company BASF under the name Eumulgin CO 40®. marketed under the name Tween 20® by the company CRODA, and said emulsifying agents are present in the composition in a content ranging from 1% to 25% by weight, preferably from 5% to 7% by weight, even more preferably 6% by weight, relative to the total weight of the composition.In particular, Cremophor GS 32® is present in the composition in a content ranging from 0.6% to 8.5% by weight, preferably 2% by weight, relative to the total weight of the composition; and / or Eumulgin CO 40® is present in the composition in a content ranging from 0.6% to 8.5% by weight, preferably 2% by weight, relative to the total weight of the composition; and / or polysorbate 80 is present in the composition in a content ranging from 0.5% to 7.5% by weight, preferably 2% by weight, relative to the total weight of the composition; and / or polysorbate 20 is present in the composition in a content ranging from 0.5% to 7.5% by weight, preferably 2% by weight, relative to the total weight of the composition.

[0064] In a particular embodiment of the invention, the aqueous phase of the composition comprises water in a content of 62% to 91% by weight, preferably 77% to 87% by weight, even more preferably 82.5% or 83.9% or 85.7% by weight, and glycerol in a content ranging from 4.5% to 12% by weight, preferably 5% by weight, and the oily phase of the composition comprises a triglyceride of caprylic acid and capric acid such as Myritol 318® in a content ranging from 0.5% to 8% by weight, preferably 2% by weight, as well as a mixture of emulsifying agents consisting of Cremophor GS 32® in a content ranging from 0.6% to 8.5% by weight, preferably 2% by weight, Eumulgin CO 40® in a content ranging from 0.6% to 8.5% by weight, preferably 2% by weight, of polysorbate 80 or polysorbate 20 in a content ranging from 0.5% to 7.5% by weight, preferably 2% by weight, all percentages being given relative to the total weight of the composition. Semiochemical composition

[0065] The oily phase of the composition according to the invention further comprises a semiochemical composition as active agent, as defined above. Said semiochemical composition is in particular soluble in the oily phase described here. Particular semiochemical compositions are described above as well as in the preferred embodiments and experimental examples which follow. The semiochemical compositions contained in the compositions according to the invention are in particular intended for non-therapeutic use, for example use for their behavioral or protective effect against pests (parasites, insects, etc.) on the animals to which they are administered or on the animals interacting with the latter, or for their well-being effect on humans.

[0066] The semiochemical composition may be present in the composition in the form of an oil-in-water emulsion in a content ranging from 1% to 4% by weight, preferably from 1.5% to 2.5% by weight, even more preferably from 1.98% or 2% by weight of said semiochemical composition, relative to the total weight of the O / W composition according to the invention. Additives

[0067] The composition according to the invention may further comprise at least one additive provided that it does not interfere with the desired properties of the composition, in particular with its property of being an O / W emulsion.

[0068] In a particular embodiment of the invention, said at least one additive is chosen from the group consisting of a preservative agent, in particular an antimicrobial agent or an antioxidant agent, a perfume, a masking agent, and mixtures thereof.

[0069] In the context of the invention, the term "preservative agent" refers to an agent protecting the composition according to the invention against the transformation of its physical or chemical state, its color, its odor or even protecting it from microbial contamination or degradation, for example by inhibiting the development of microorganisms during the storage or use time of the composition according to the invention. Such an agent must be compatible with use of the composition according to the invention in contact with an animal or a human, and is advantageously non-irritating to the skin and eyes.

[0070] Examples of preservatives are known to those skilled in the art and include in particular benzyl alcohol, didecyldimonium chloride, caprylyl glycol, phenylpropanol, sodium benzoate, phenyl acetate, sorbic acid, dehydroacetic acid, potassium sorbate, phenoxyethanol, cetrimonium bromide, triclosa, parabens, thiazolinones.

[0071] In the context of the invention, the term “antimicrobial agent” therefore refers to a preservative agent making it possible to slow down the growth of microorganisms (bacteria, fungi, yeasts, molds) and combating the development of microbes in the composition according to the invention, when it is preserved and / or when it is used.

[0072] Examples of antimicrobial agents are known to those skilled in the art and include in particular Glycerin / phenyl alcohol / caprylhydroxamic acid, notably marketed under the name Aromastat® by the company INOLEX.

[0073] The composition according to the invention may comprise from 0% to 4% by weight, preferably from 0.2% to 3.2% by weight, even more preferably 1% by weight of preservative, in particular of antimicrobial agent relative to the total weight of the composition according to the invention.

[0074] In the context of the invention, the term "antioxidant agent" refers to a preservative agent capable of inhibiting reactions promoted by oxygen, thus preventing oxidation.

[0075] Examples of antioxidant agents are known to those skilled in the art and include in particular compounds of the cinnamic acid family and their derivatives, such as pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate in particular marketed under the name Tinogard TT® by the company BASF, vitamin A (retinol), vitamin C (ascorbic acid) and derivatives (ascobate), vitamin E (tocopherol) and derivatives (tocopheryl), preferably Tinogard TT®.

[0076] The composition according to the invention may comprise from 0% to 2% by weight, preferably from 0.02% to 0.3% by weight, even more preferably 0.1% by weight of antioxidant agent, relative to the total weight of the composition.

[0077] In the context of the invention, the term “perfume” or perfuming agent refers to any hydrophobic substance designating a pure body or a mixture insoluble or very slightly soluble in water capable of releasing a pleasant odor.

[0078] The composition according to the invention may comprise from 0% to 3% by weight, preferably from 0.2% to 2.5% by weight, even more preferably 1% by weight of perfume, relative to the total weight of the composition.

[0079] In the context of the invention, the term "masking agent" refers to an agent that reduces or inhibits the basic odor or taste of the product.

[0080] Examples of masking agents are known to those skilled in the art and include in particular beta sitosterol, citric acid, bisabolol, calendula officenalis flower extract.

[0081] The composition according to the invention may comprise from 0% to 3% by weight, preferably from 0.2% to 2.5% by weight, even more preferably 1% by weight of a masking agent, relative to the total weight of the composition.

[0082] In a particular embodiment according to the invention, said at least one additive is added to the oily phase, i.e., the oily phase further comprises at least one additive as defined previously.

[0083] In another particular embodiment according to the invention, said at least one additive, for example a perfume, is added after the formation of the oil-in-water emulsion, or after a step of adjusting the pH of the oil-in-water emulsion.

[0084] In a preferred embodiment according to the invention, the oily phase further comprises at least one additive chosen from the group consisting of a preservative, in particular an antimicrobial agent or an antioxidant agent, a perfume, a masking agent, and mixtures thereof, even more preferably at least one additive chosen from the group consisting of a preservative, in particular an antimicrobial agent or an antioxidant agent, a masking agent, and mixtures thereof.

[0085] In another preferred embodiment according to the invention, the composition according to the invention further comprises at least one additive such as a perfume. Said perfume is in particular added after the formation of the oil-in-water emulsion or after a step adjusting the pH of the oil-in-water emulsion to avoid fragrance degradation or loss of perfume scent.

[0086] In a preferred embodiment of the invention, the composition according to the invention comprises: (a) an aqueous phase comprising water and glycerol, b) an oily phase comprising polyglyceryl-3 distearate (Cremophor GS 32 ® marketed in particular by BASF), PEG-40 hydrogenated castor oil (Eumulgin CO 40® marketed in particular by BASF), polyoxyethylene sorbitan fatty acid esters (polysorbate 80 marketed in particular under the name Tween 80® by CRODA or polysorbate 20 marketed in particular under the name Tween 20® by CRODA), caprylic acid and capric acid triglycerides (Myritol 318® marketed in particular by BASF), Glycerin / phenyl alcohol / caprylhydroxamic acid (Aromastat® marketed in particular by INOLEX), pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate (Tinogard TT® marketed in particular by BASF), a possible perfume, and a semiochemical composition, the semiochemical composition being present in the composition in the form of an oil-in-water emulsion in a content ranging from 1% to 4% by weight, preferably from 1.5% to 2.5% by weight, relative to the total weight of the O / W composition according to the invention.

[0087] In an even more preferred embodiment of the invention, the composition according to the invention comprises: a) an aqueous phase comprising water in a content of 62% to 91% by weight, preferably 77% to 87% by weight, even more preferably 82.5% or 83.9% or 85.7% by weight, and glycerol in a content ranging from 4.5% to 12% by weight, preferably 5% by weight, b) an oily phase comprising polyglyceryl-3 distearate (Cremophor GS 32 ® marketed in particular by the company BASF) in a content ranging from 0.6% to 8.5% by weight, preferably 2% by weight, preferably x% by weight, PEG-40 hydrogenated castor oil (Eumulgin CO 40® marketed in particular by the company BASF) in a content ranging from 0.6% to 8.5% by weight, preferably 2% by weight, fatty acid esters of polyoxyethylene sorbitan (polysorbate 80 marketed in particular under the name Tween 80® by the company CRODA or polysorbate 20 marketed in particular under the name Tween 20® by the company CRODA) in a content ranging from 0.5% to 7.5% by weight, preferably 2% by weight, caprylic acid triglycerides and capric acid (Myritol 318® marketed in particular by BASF) in a content ranging from 0.5% to 8% by weight, preferably 2% by weight, Glycerin / phenyl alcohol / caprylhydroxamic acid (Aromastat® sold in particular by the company INOLEX) in a content ranging from 0.2% to 3.2% by weight, preferably 1% by weight, pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate (Tinogard TT® sold in particular by the company BASF) in a content ranging from 0.02% to 0.3% by weight, preferably 0.1% by weight, an optional perfume in a content ranging from 0.2% to 2.5% by weight, preferably 1% by weight, and a semiochemical composition, the semiochemical composition being present in the composition in the form of an oil-in-water emulsion in a content ranging from 1% to 4% by weight, preferably from 1.5% to 2.5% by weight, the contents being expressed by weight relative to the total weight of the composition H / E according to the invention.

[0088] In a particular embodiment of the invention, the composition has a Brookfield viscosity of less than 8500 mPa.s, in particular a viscosity of between 1 and 50 cP or mPa.s, or a viscosity of between 3500 and 8000 cP or mPa.s, as measured at 25°C. The viscosity within the meaning of the present invention is a Brookfield viscosity measured at room temperature (25°C), preferably after 24 hours, using a viscometer, for example a Brookfield digital viscometer (model LDVI Prime), S 61 spindle and rotation speed 0.6 RPM.

[0089] In a particular embodiment of the invention, the composition in the form of an oil-in-water (O / W) emulsion has a pH of between 5 and 8, preferably a pH of between 5.5 and 7.5, or a pH of between 6.0 and 7.5.

[0090] Preferably, the composition has a pH value compatible with topical application, in particular cutaneous application of the composition on the skin of an animal or human skin.

[0091] Process for preparing the composition according to the invention

[0092] The invention also relates to a first process for preparing a composition according to the invention, comprising the following steps: a) said at least one gelling agent is pasted into said at least one humectant; then water is added with stirring and at a temperature between 65°C and 75°C, preferably at a temperature of 70°C, so as to obtain a homogeneous aqueous phase; b) mixing said at least one emollient agent, said at least one emulsifying agent, said semiochemical composition and optionally said at least one additive, with stirring and at a temperature between 65°C and 75°C, preferably at a temperature of 70°C, so as to obtain a homogeneous oily phase; c) the oily phase from step b) is added with stirring to the aqueous phase from step a) so as to obtain an oil-in-water (O / W) emulsion; d) optionally the pH of the emulsion obtained in step c) is adjusted; e) optionally add a perfume; f) the composition is recovered in the form of an oil-in-water (O / W) emulsion obtained in step c), d) or e).

[0093] The invention also relates to a second process for preparing a composition according to the invention, comprising the following steps: a) said at least one gelling agent is pasted into said at least one humectant; then water is added with stirring and at a temperature between 65°C and 75°C, preferably at a temperature of 70°C, so as to obtain a homogeneous aqueous phase; b) mixing said at least one emollient agent, said at least one emulsifying agent, said semiochemical composition, with stirring and at a temperature between 65°C and 75°C, preferably at a temperature of 70°C, so as to obtain a homogeneous oily phase; c) the oily phase from step b) is added with stirring to the aqueous phase from step a) so as to obtain an oil-in-water (O / W) emulsion; d) optionally the pH of the emulsion obtained in step c) is adjusted; e) optionally adding said at least one additive; f) the composition is recovered in the form of an oil-in-water (O / W) emulsion obtained in step c), d) or e).

[0094] Preferably, the invention relates to the first process for preparing a composition according to the invention.

[0095] The definitions and / or particular / preferred embodiments mentioned in the following paragraphs are applicable to both the first and second processes for preparing a composition according to the invention.

[0096] In the context of the invention, the term "pasting" means that before adding the water in step a) of the process, said at least one gelling agent is dispersed in said at least one humectant, in order to obtain a smooth and homogeneous paste. This pasting step known to those skilled in the art makes it possible to separate the particles and avoid the formation of lumps.

[0097] In a particular embodiment of the first or second process according to the invention, the pasting step a) is carried out at room temperature; and / or - the homogeneous aqueous phase obtained in step a) is kept stirring at a temperature between 65°C and 75°C, preferably at a temperature of 70°C; and / or - the homogeneous oily phase obtained in step b) is kept stirring at a temperature between 65°C and 75°C, preferably at a temperature of 70°C; and / or - step c) is carried out by mixing the oily phase from step b) in the aqueous phase of step a) at a temperature between 65°C and 75°C, preferably at a temperature of 70°C, and the emulsion is cooled to room temperature; and / or - step d) is carried out by adding a basic solution, for example a NaOH solution, in particular a 10% NaOH solution in order to increase the pH of the emulsion obtained in step c), preferably in order to obtain a pH of between 5 and 8, preferably a pH of between 5.5 and 7.5, or a pH of between 6.0 and 7.5.

[0098] In a particular embodiment of the process according to the invention, the aqueous phase obtained in step a) is in the form of a homogeneous mixture.

[0099] In a particular embodiment of the process according to the invention, the oily phase obtained in step b) is in the form of a homogeneous mixture.

[0100] In the context of the invention, the term “homogeneous mixture” refers to a mixture whose different constituents cannot be distinguished with the naked eye.

[0101] In a particular embodiment of the process according to the invention, the oil-in-water (O / W) emulsion obtained in step c) is a stable and homogeneous emulsion as defined previously.

[0102] In a particular embodiment of the process according to the invention, step d) is mandatory for the preparation of a composition in the form of an oil-in-water (O / W) emulsion, comprising a semiochemical composition comprising from 40% to 60% of 3-cyclopentyl propionic acid and from 40% to 60% of 3-cyclohexyl propionic acid; preferably 50% of 3-cyclopentyl propionic acid and 50% of 3-cyclohexyl propionic acid (CS9).

[0103] The subject of the invention is in particular a process for preparing a composition according to the invention, in particular a first or second process for preparing a composition according to the invention as described previously, in which the compounds of the aqueous and oily phases are as described above.

[0104] The invention also relates to the use of a composition consisting of an aqueous phase and a composition consisting of an oily phase as described above and exemplified below, for producing a composition according to the invention comprising as active agent a semiochemical composition (associated with the oily phase), in the form of an oil-in-water (O / W) emulsion, in particular an oil-in-water emulsion which is stable and has a homogeneous appearance. In particular, the composition is suitable for use with a spraying device, in particular a mist sprayer. Non-therapeutic use according to the invention

[0105] According to another aspect, the invention relates to a non-therapeutic use of a composition according to the invention. According to this use, the composition according to the invention is used to obtain the expected semiochemical effect(s) of the composition se- semiochemical that it contains. Thus, a composition according to the invention is used to improve the management of behaviors or interactions of target animals or their well-being, by the transmission of information or signals vectorized by semiochemical agents, or to improve the well-being of humans.

[0106] A use of the composition according to the invention is for example a use as a tool or means for improving animal breeding. A use of the composition according to the invention is for example a use as a tool or means for adapting the animal to its environment.

[0107] The non-therapeutic use of the composition according to the invention comprises the topical administration, in particular cutaneous, of said composition to an animal, in particular a mammal, or to a human, or to animals treated in a group.

[0108] The non-therapeutic use of the composition according to the invention comprises administration, in particular by spraying using a mist sprayer, onto the skin of an animal or a human, or onto the skin of farm animals treated in groups, or onto an element of the environment such as textiles and / or objects and / or walls, or by spraying into the air, in particular near the nose of an animal or a human, in particular to reduce and / or avoid obtaining a wetting effect or stains; or to reach the vomeronasal and olfactory mucosa more quickly.

[0109] In a particular embodiment according to the invention, the composition is administered topically, in particular cutaneously, on the skin of an animal or on human skin, preferably on the skin of an animal.

[0110] In a particular embodiment according to the invention, the animal is a domestic animal or a farm animal, in particular a mammal, preferably the animal is chosen from the group consisting of pets such as rabbits, cats, dogs, birds or from the group of farm animals such as horses or production animals such as pigs, cattle, sheep, poultry, for example chickens.

[0111] In a particular embodiment according to the invention, the composition comprises a semiochemical composition, in particular comprising a bovine appeasing pheromone, comprising from 25% to 35% of methyl oleate, from 20% to 25% of methyl linoleate, from 20% to 25% of methyl behenate, from 20% to 25% of methyl palmitate, from 3% to 6% of methyl myristate and from 2% to 4% of methyl laurate; and relates to the non-therapeutic use of said composition for administration, in particular by spraying using a mist sprayer, in particular topical administration, in particular cutaneous to bovines or bovines treated in groups, in particular on the skin of a bovine or bovines, in particular to promote calming states in bovines.

[0112] In a particular embodiment according to the invention, the composition comprises a semiochemical composition, in particular comprising a pig appeasing pheromone, comprising from 30% to 40% methyl linoleate, from 25% to 35% methyl oleate, from 15% to 25% methyl palmitate, from 5% to 9% methyl myristate, from 5% to 7% methyl laurate and from 1% to 3% methyl decanoate; and relates to the non-therapeutic use of said composition for administration, in particular by spraying using a mist sprayer, in particular topical administration, in particular cutaneous to pigs or groups of pigs, in particular on the skin of a pig or pigs, in particular for promoting calming states in pigs.

[0113] In a particular embodiment according to the invention, the composition comprises a semiochemical composition, in particular comprising a dog appeasing pheromone, comprising from 25% to 35% of methyl linoleate, from 25% to 35% of methyl oleate, from 15% to 25% of methyl palmitate, from 10% to 15% of methyl stearate, from 2% to 7% of methyl myristate, from 2% to 6% of methyl pentadecanoate and from 1% to 3% of methyl laurate;and relates to the non-therapeutic use of said composition for administration, in particular by spraying using a mist sprayer, in particular topical administration, in particular cutaneous to dogs, in particular on the skin of a dog, or administration on an element of the environment such as textiles and / or objects and / or walls, in particular to facilitate adaptation and prevent stress induced by encounters with unknown dogs, humans or animals, and / or prevent stress reactions induced by external factors such as fireworks, thunderstorms, loud noises or unusual environments. ;

[0114] In a particular embodiment according to the invention, the composition comprises a semiochemical composition, in particular comprising a rabbit appeasing pheromone, comprising from 30% to 40% of methyl linoleate, from 25% to 35% of methyl oleate, from 15% to 25% of methyl palmitate, from 5% to 15% of 2-(2-butoxyethoxy)ethanol, from 2% to 6% of dimethyl glutarate, from 1% to 3% of dimethyl adipate, from 1% to 3% of dimethyl succinate and from 1% to 3% of dodecane;and relates to the non-therapeutic use of said composition for administration, in particular by spraying using a mist sprayer, in particular topical administration, in particular cutaneous to rabbits, in particular on the skin of a rabbit, or administration on an element of the environment such as objects and / or walls, in particular to promote well-being in the rabbit, for example to promote positive emotional states in the rabbit, in particular to facilitate adaptation to transport, during examination by the veterinarian, during encounters with unknown animals or people, upon arrival in an unknown place, or any other circumstance of the daily life of a rabbit. ;

[0115] In a particular embodiment according to the invention, the composition comprises a semiochemical composition, in particular comprising a pheromone soothing to a human, comprising from 25% to 35% of methyl oleate, from 25% to 35% of methyl palmitate, from 25% to 35% of methyl linoleate, from 3% to 7% of methyl stearate, from 3% to 5% of methyl myristate and from 0.5% to 2% of methyl pentadecanoate; and relates to the non-therapeutic use of said composition for administration, in particular by spraying using a mist sprayer, in particular topical administration, in particular cutaneous to a human, in particular on the skin of a human, or administration on an element of the environment such as textiles and / or objects and / or walls, in particular to promote well-being in humans.

[0116] In a particular embodiment according to the invention, the composition comprises a semiochemical composition, in particular comprising a sheep appeasing pheromone, comprising from 30% to 40% of methyl oleate, from 20% to 26% of methyl linoleate, from 20% to 26% of methyl palmitate, from 6% to 10% of squalene, from 2% to 6% of methyl myristate and from 3% to 5% of methyl pentadecanoate; and relates to the non-therapeutic use of said composition for administration, in particular by spraying using a mist sprayer, in particular topical administration, in particular cutaneous to sheep or groups of sheep, in particular on the skin of a sheep or sheep, in particular to promote calming states in sheep.

[0117] In a particular embodiment according to the invention, the composition comprises a semiochemical composition, in particular comprising a feline facial pheromone, comprising from 62% to 70% of methyl oleate, from 12% to 16% of methyl palmitate, from 7% to 13% of dimethyl pimelate and from 6% to 11% of dimethyl azelate; and relates to the non-therapeutic use of said composition for administration, in particular by spraying using a mist sprayer, in particular topical administration, in particular cutaneous to cats, in particular on the skin of a cat, or administration on an element of the environment such as textiles and / or objects and / or walls, in particular for preventing and managing stress-induced urine marking behavior in cats.

[0118] In a particular embodiment according to the invention, the composition comprises a semiochemical composition, in particular comprising a mixture of feline facial pheromone and cat appeasing pheromone, comprising from 2% to 6% of methyl laurate, from 2% to 6% of methyl myristate, from 1% to 15% of methyl palmitate, from 2% to 6% of methyl stearate, from 42% to 50% of methyl oleate, from 4% to 8% of methyl linoleate, from 7% to 13% of dimethyl pimelate and from 6% to 11% of dimethyl azelate; and relates to the non-therapeutic use of said composition for administration, in particular by spraying using a mist sprayer, in particular topical administration, in particular cutaneous to cats, in particular on the skin of a cat, or administration on an element of the environment such as objects and / or walls, in particular for preventing and managing stress-induced urine marking behavior in cats.

[0119] In a particular embodiment according to the invention, the composition comprises a semiochemical composition, comprising from 40% to 60% of 3-cyclopentyl propionic acid and from 40% to 60% of 3-cyclohexyl propionic acid; and relates to the non-therapeutic use of said composition for administration, in particular by spraying using a mist sprayer, in particular topical administration, in particular cutaneous to an animal, in particular a mammal, or to a human, or to animals treated in a group, or administration on an element of the environment such as textiles and / or objects and / or walls, in particular to prevent bites by hematophagous invertebrates, in particular hematophagous insects, such as mosquitoes, mites or ticks.

[0120] In a particular embodiment according to the invention, the composition comprises a semiochemical composition, in particular comprising an allomone produced by the uropygial glands of the duck, comprising from 40% to 60% of bis(2-ethylhexyl) adipate and from 40% to 60% of l-isopropyl-2,2-dimethyltrimethylene diisobutyrate; and relates to the non-therapeutic use of said composition for administration, in particular by spraying using a mist sprayer, in particular topical administration, in particular cutaneous to poultry such as chickens, in particular on the skin of poultry such as chickens, in particular as a repellent allomone, in particular for preventing infestation by parasites such as the red poultry mite (Dermanyssus sp. or Omithonyssus sylviarum).

[0121] Another non-therapeutic use of said composition relates to an administration, in particular by spraying using a mist sprayer, in particular a topical administration, in particular cutaneous to an animal, for example birds or mammals, in particular on the skin of birds or mammals, or to a human, in particular on human skin, or an administration on an element of the environment such as textiles and / or objects and / or walls, or by spraying in the air, in particular near the nose of an animal or a human, in particular to prevent infestation or bites by blood-sucking invertebrates, in particular blood-sucking insects, such as mosquitoes, mites or ticks.

[0122] In a particular embodiment according to the invention, the composition comprises a semiochemical composition, in particular an equine soothing pheromone, comprising from 35% to 45% by weight of methyl oleate, from 20% to 30% by weight of methyl palmitate, from 20% to 30% by weight of methyl linoleate, from 2% to 7% by weight of weight of dioxolane, from 1% to 5% by weight of methyl laurate and from 1% to 4% by weight of methyl myristate; and relates to the non-therapeutic use of said composition for administration, in particular by spraying using a mist sprayer, in particular topical administration, in particular cutaneous to horses, in particular on the skin of a horse, or administration on an element of the environment such as textiles and / or objects and / or walls, in particular to prevent social stress in the horse and / or aggressive behavior induced by encounters with unknown conspecifics, unknown people or animals of other species.

[0123] The above-mentioned uses of said composition according to the invention are non-therapeutic uses, and exclude any therapeutic use carried out on the animal or human body. Examples

[0124] The following examples are given for purely illustrative purposes, and should not be interpreted in any way as limiting the invention. Example 1. Oil-in-water emulsions (mist)

[0125] Compositions in the form of an oil-in-water emulsion (mist) according to the invention having the composition shown in the following Table 1 were prepared.

[0126] [Tables 1] Compound Name INCI Function CAS No. Weight Percentage Aqueous Phase Water AQUA 7732-18-5 qsp Glycerol Humectant GLYCERIN 56-81-5 5% Oily Phase Cremophor GS 32 Emulsifying Agent POLYGLYCERYL- 3 DISTEARATE 9009-32-9 / 94423-19-5 2.0% Eumulgin CO 40 Emulsifying Agent PEG-40 HY- DROGENATED CASTOR OIL 61788-85-0 2.0% Polysorbate 80 or 20 Emulsifying Agent POLYSORBATE 80 9005-65-6 or 9005-64-5 2.0% Myritol 318 Emollient Agent CAPRYLIC / CAPRI C TRIGLYCERIDE 73398-61-5 2.0 Aromastat Antimicrobial Agent GLYCERIN / PHENE THYL ALCOHOL CAPRYLHYDROX AMIC ACID 56-81-5 60-12-8 7377-03-9 1.0% Tinogard TT Antioxidant Agent PENTAERYTHRIT YL TETRA-DLT-BUTYL HY-DROXYHYDROCI NNAMATE 6683-19-8 0.1% Perfume (optional) Additive / / 1.0% Semiochemical Composition (CS1, CS2, CS3, CS4 or CS5, CS6, CS7, CS8, CS9, CS 10 or CS11) / / 1.98% NaOH solution 10% (only with CS9) SODIUM HYDROXIDE 1310-73-2 0.40%

[0127] Semiochemical compositions (CS) used as examples in the formulation of Table 1 - CS1: 27.40% methyl oleate, 22.70% methyl linoleate, 21.20% methyl behenate, 21.20% methyl palmitate, 4.50% methyl myristate and 3% methyl laurate; or - CS2: 35% methyl linoleate, 30% methyl oleate, 20% methyl palmitate, 7% methyl myristate, 6% methyl laurate and 2% methyl decanoate; or - CS3: 29% methyl linoleate, 29% methyl oleate, 18% methyl palmitate, 13% methyl stearate, 5% methyl myristate, 4% methyl pentadecanoate and 2% methyl laurate; or - CS4: 35% methyl linoleate, 29% methyl oleate, 18% methyl palmitate, 9.18% 2-(2-butoxyethoxy)ethanol, 4.32% dimethyl glutarate, 1.62% dimethyl adipate, 1.62% dimethyl succinate and 1.26% dodecane; or - CS5: 30.80% methyl oleate, 30% methyl palmitate, 28.80% methyl linoleate, 5.50% methyl stearate, 3.55% methyl myristate and 1.35% methyl pentadecanoate; or - CS6: 35.3% methyl oleate, 23.7% methyl linoleate, 23.3% methyl palmitate, 8.6% squalene, 5.2% methyl myristate and 3.9% methyl pentadecanoate; or - CS7: 67.2% methyl oleate, 13.60% methyl palmitate, 11.40% dimethyl pimelate and 7.80% dimethyl azelate; or - CS8: 4.50% methyl laurate, 4.50% methyl myristate, 13.40% methyl palmitate, 4.50% methyl stearate, 46.6% methyl oleate, 69.50% methyl linoleate, 11% dimethyl pimelate and 9% dimethyl azelate; or - CS9: 50% 3-cyclopentyl propionic acid and 50% 3-cyclohexyl pro-pionic acid; or - CS 10: 50% bis(2-ethylhexyl) adipate and 50% l-isopropyl-2,2-dimethyltrimethylene diisobutyrate; or - CS11: from 35% to 45% by weight of methyl oleate, from 20% to 30% by weight of methyl palmitate, from 20% to 30% by weight of methyl linoleate, from 2% to 7% by weight of dioxolane, from 1% to 5% by weight of methyl laurate and from 1% to 4% by weight of methyl myristate.

[0128] Example 2. Process for preparing oil-in-water emulsions (mist) according to Example 1

[0129] The oil-in-water emulsions (mist) according to Example 1 were prepared according to the following protocol: STEP 1: Preparation of the mash / aqueous phase 1. In a container suitable for receiving the final volume of the aqueous phase, the glycerin was weighed and added. The mixture was stirred at room temperature. 2. Once the mashing is done, all the water is added. 3. After homogenization of the aqueous phase (obtaining a homogeneous mixture), the aqueous phase was maintained at 70°C and stirred until step 3. STEP 2: Preparation of the oil phase 4. In another container suitable for receiving the final volume of the oil phase, the compounds of the oil phase, namely Cremophor GS 32, Eumulgin CO 40, Polysorbate 80 or Polysorbate 20, Myritol 318, Tinogard TT, Aromastat and the semiochemical composition (CS1, CS2, CS3, CS4 or CS5, CS6, CS7, CS8, CS9 or CS 10) were weighed and added. 5. Once all the compounds were added, the mixture was stirred and heated to 70°C until a homogeneous mixture was obtained. STEP 3: Formation of the oil-in-water emulsion 6. When the two phases (aqueous and oily) were perfectly homogeneous, the oily phase at 70°C was added to the aqueous phase at 70°C. Care was taken to ensure that the emulsion was well stirred throughout this step. The emulsion was then cooled to room temperature after homogenization of the emulsion. STEP 4: Changing the pH only with the above-mentioned CS9 composition 7. In the case of the composition comprising the semiochemical composition CS9, and in order to increase the pH, a pH adjustment step was carried out by adding a 10% NaOH solution until a pH between 6 and 7 was obtained. STEP 5: Perfume 8. Addition of a possible perfume while stirring at room temperature STEP 6: Recovery of the oil-in-water (O / W) emulsion The final emulsion obtained was fluid, opalescent / transparent, of low viscosity.

[0130] Example 3. Organoleptic measurements of oil-in-water emulsions (mist) according to Example 1

[0131] 3 criteria (appearance, color, odor) were selected for the organo measurements leptics. Appearance: Flowing liquid Color: White or opalescent / transparent / translucent Odor: Characteristic odor.

[0132] Example 4. pH measurements of oil-in-water emulsions (mist) according to Example 1

[0133] The pH measurements were carried out using an LE 438 IP 67 electrode marketed by Mettler Toledo®. This is a 2-in-1 glass pH electrode with integrated temperature sensor and liquid electrolyte for rapid laboratory measurements; for aqueous samples, such as acids, bases, etc.

[0134] The specifications of this electrode are mentioned in the following Table 2.

[0135] [Tables2] Measuring range pH 0 - 14 Zero point 7.00 ± 0.25 Temperature range 0 - 80 °C Temperature sensor NTC 30 KQ Membrane resistance (25 °C) < 250 MQ Reference electrolyte 3 mol / L KC1 solution saturated with AgCl Reference system Ag / AgCl Reference diaphragm Gel

[0136] Prior to any measurement, the pH meter used was calibrated. Indeed, the nature of the semiochemical composition can cause the pH of the emulsion to change because certain semiochemicals have an acidic pH. In the context of a topical application, in particular cutaneous, it is therefore necessary to measure the pH of each emulsion obtained and possibly adjust the pH in order to obtain a pH between 5 and 8, preferably a pH between 5.5 and 7.5, or a pH between 6.0 and 7.5.

[0137] pH measurements were carried out after obtaining each emulsion, and are reported below: MIST with CS1: 5.0 < pH < 7.5 MIST with CS2: 5.0 < pH < 7.5 MIST with CS3: 5.5 < pH < 7.5 MIST with CS4: 5.5 < pH < 7.5 MIST with CS5: 5.5 < pH < 7.5 MIST with CS6: 5.5 < pH < 7.5 MIST with CS7: 5.5 < pH < 7.5 MIST with CS8: 5.5 < pH < 7.5 MIST with CS10: 5.5 < pH < 7.5 MIST with CS11: 5.5 < pH < 7.5 MIST with CS9: 3.5 < pH < 4.5.

[0138] In order to get as close as possible to the pH of animal or human skin, and to avoid causing an irritating skin reaction, a pH adjustment was made for the formulation corresponding to BRUME with CS9. Following this adjustment, new pH measurements were carried out and are reported below: MIST with CS9: 6.0 < pH < 7.5.

[0139] For formulations corresponding to MIST with CS1, CS2, CS3, CS4, CS5, CS6, CS7, CS8, CS10 and CS11, no pH adjustment step was performed.

[0140] Example 5. Measurement of the viscosity of oil-in-water emulsions (mist) according to Example 1

[0141] Viscosity is the resistance of a fluid to sliding of one layer relative to another.

[0142] For each formulation, the viscosity must be checked after each manufacture. The viscosity is influenced by a number of factors including the temperature, the measuring device used, the measuring speed used, the time of measurement relative to manufacture (measurements at T0 and T+24h, T+48h). The viscosity measurement must be carried out when the solution is at room temperature, preferably at T+24h.

[0143] The measurement of the viscosity of the oil-in-water emulsions according to Example 1 was carried out using the Brookfield digital viscometer (model DV-I Prime), spindle S 61 (large spindle) and at a rotation speed of 0.6 RPM.

[0144] The DV-I Prime Brookfield viscometer measures the viscosity of fluids at a given velocity gradient. The operating principle consists of rotating a spindle (which is immersed in the liquid to be tested) by means of a calibrated spring. The measuring range (in centipoise or milliPascal-second) is determined by the spindle rotation speed, the size and shape of the spindle, the section where the spindle is rotating and the full scale of the calibrated spring torque.

[0145] The specifications of the DV-I Prime Brookfield viscometer are reported in the Table 3 below.

[0146] [Table 3]: Speeds (rpm) 0.0; 0.3; 0.6; 1.5; 3; 6; 12; 30; 60; 0.5; 1; 2; 2.5; 4; 5; 10; 20; 50; 100 Viscosity Range (cP) 15 - 2,000,000 Operating Environment Temperature Range 0°C to 40°C (32°F to 104°F) 20% to 80% RH: None condensation Analog output of torque 0-1 Vdc (torque from 0 to 100%) Viscosity measurement accuracy ± 1 °C: -of full scale Viscosity measurement reproducibility 0.2% of full scale used Mobiles used S61; S62; S63; S64

[0147] Following these measurements, all the oil-in-water emulsions (mist) according to Example 1 had a viscosity of between 1 and 50 cP or mPa.s, with the exception of the emulsion comprising the semiochemical composition CS9 which had a viscosity of between 3500 and 8000 cP or mPa.s. The viscosity was notably lower in the presence of a perfume or a NaOH solution (the percentage of water being higher).

[0148] Example 6. Test to identify the presence or absence of stains following spraying of the semiochemical composition CS9 on different textiles of different materials

[0149] Protocol - Place the garment on a hanger, take a photo before application (T0) - Spray the semiochemical composition CS9 20-30 cm from the garment on different areas [10 sprays per garment, if the garment is in 2 parts (example: trousers) carry out 5 sprays per side] - Photo after application (Tl) - Take a photo 1h after application (T2) - Wash clothes in a washing machine (classic program at 30°C) - Take a photo after washing (T3).

[0150] Material Solution used Semiochemical composition CS9 Clothing and its composition The compositions and types of clothing used are reported in Table 4 below.

[0151] [Table 4]: Composition Type of clothing 100% cotton White polo shirt Blue t-shirt 100% polyester Blue t-shirt Black polo shirt 35% polyamide, 30% wool, 30% viscose, Blue sweater 5% cashmere 100% wool Cardigan 60% recycled wool, 35% polyester, 5% polyamide Pants 100% silk Tie 100% synthetic Black dress

[0152] Results The results of the tests carried out by the inventors are reported in the following Table 5.

[0153] [Table 5]: Type of clothing Material T0 Tl T2 T3 White polo shirt 100% cotton N / A N / A N / A Blue t-shirt Trace of "water" N / A N / A Blue t-shirt 100% polyester N / A N / A N / A Black polo shirt Droplets depositing on the fibers N / A N / A N / A Blue sweater 35% polyamide, 30% wool, 30% viscose, 5% cashmere N / A N / A N / A Cardigan 100% wool N / A N / A N / A (has shrunk) Trousers 60% recycled wool, 35% polyester, 5% polyamide Water droplets depositing on the fibers N / A N / A N / A Tie 100% silk Trace of "water" N / A N / A N / A Black dress Synthetic Droplets depositing on the fibers N / A N / A N / A

[0154] RAS = “Nothing to report”, i.e., no changes observed. The above-mentioned results showed that no stains were observed on different textiles of different materials following the spraying of the semiochemical composition CS9.

[0155] Example 7. Acceptability tests in cats and rabbits

[0156] The results of the acceptability tests in cats carried out by the inventors are reported in the following Table 6.

[0157] [Table 6]: Results of the acceptance questionnaire - Cat Reaction DURING application High-pitched cries, without escape or defensive movements Ears on the back of the head, growling, active defensive reactions The cat remains in place, but tail swaying is observed The cat tries to free itself without a sudden reaction, during application The cat remains in place, but with its ears pressed against the back of its head or in a policeman's hat position The cat shows no particular reaction Number of reactions observed 0 0 0 4 0 9 Reaction AFTER APPLICATION The cat hides and is unapproachable (threatening facial expressions and vocalizations) The cat remains in place, but can no longer be touched (threatening facial expressions and vocalizations) The cat shows very active and prolonged grooming behavior After a short licking time, the cat resumes its usual activities Number of reactions observed 0 0 3 10 Analogue scale of product odor Average 7 / 10

[0158] The results of the acceptability tests in rabbits carried out by the inventors are reported in the following Table 7.

[0159] [Table?]: Acceptance questionnaire results - Rabbit Reaction DURING application Sudden escape movements (jumping, forward movements) Defensive movements with hindquarters Screams The rabbit flattens itself on the table No reaction or shakes itself slightly Number of reactions observed 0 0 0 0 4 Reaction AFTER APPLICATION The rabbit no longer lets itself be approached (flees) The rabbit remains flat on the ground, trembles The rabbit exhibits very prolonged grooming behavior The rabbit exhibits no reaction and resumes its usual activities Number of reactions observed 0 0 1 3 Analogue scale of product odor Average 7 / 10 References

[0160] - Silverstein, R.M., 1977. "Complexity, diversity and specificity of behavior- modifying Chemicals; examples from Coleoptera and Hymenoptera," Chemical Control of Insect Behavior:Theory and Application. Editeurs H.H. Shorey & J.J.McKelvey pp.231-251 New York : Plénum Press); - Wyatt T.D., 2003 "Pheromones and Animal Behavior. Communication by smell and taste, pp.1-4 New York : Cambridge University Press.

Claims

Claims

1. Composition in the form of an oil-in-water (O / W) emulsion comprising: (a) an aqueous phase comprising water and at least one humectant chosen from polyols and sugars, b) an oily phase comprising at least one emollient agent, at least one emulsifying agent, and a semiochemical composition, wherein said semiochemical composition comprises: - methyl oleate and methyl palmitate, preferably methyl linoleate, methyl oleate and methyl palmitate; Or - 3-cyclopentyl propionic acid and 3-cyclohexyl pro-pionic acid; or - bis(2-ethylhexyl) adipate and l-isopropyl-2,2-dimethyltrimethylene diisobutyrate.

2. Composition in the form of an oil-in-water (O / W) emulsion according to claim 1, characterized in that said semiochemical composition comprises: - methyl oleate, methyl linoleate, methyl behenate, methyl palmitate, methyl myristate and methyl laurate; or - methyl linoleate, methyl oleate, methyl palmitate, methyl myristate, methyl laurate and methyl decanoate; or - methyl linoleate, methyl oleate, methyl palmitate, methyl stearate, methyl myristate, methyl pentadecanoate and methyl laurate; or - methyl linoleate, methyl oleate, methyl palmitate, 2-(2-butoxyethoxy)ethanol, dimethyl glutarate, dimethyl adipate, dimethyl succinate and dodecane; or - methyl oleate, methyl palmitate, methyl linoleate, methyl stearate, methyl myristate and methyl pentadecanoate; or - methyl oleate, methyl linoleate, methyl palmitate, squalene, methyl myristate and methyl pentadecanoate; or - methyl oleate, methyl palmitate, pimelate dimethyl and dimethyl azelate; or - methyl laurate, methyl myristate, methyl palmitate, methyl stearate, methyl oleate, methyl linoleate, dimethyl pimelate and dimethyl azelate; or - 3-cyclopentyl propionic acid and 3-cyclohexyl pro-pionic acid; or - bis(2-ethylhexyl) adipate and l-isopropyl-2,2-dimethyltrimethylene diisobutyrate; or - methyl oleate, methyl palmitate, methyl linoleate, dioxolane, methyl laurate and methyl myristate.

3. Composition in the form of an oil-in-water (O / W) emulsion according to claim 1 or 2, characterized in that said semiochemical composition comprises: - from 25% to 35% methyl oleate, from 20% to 25% methyl linoleate, from 20% to 25% methyl behenate, from 20% to 25% methyl palmitate, from 3% to 6% methyl myristate and from 2% to 4% methyl laurate; or - from 30% to 40% methyl linoleate, from 25% to 35% methyl oleate, from 15% to 25% methyl palmitate, from 5% to 9% methyl myristate, from 5% to 7% methyl laurate and from 1% to 3% methyl decanoate; or - from 25% to 35% methyl linoleate, from 25% to 35% methyl oleate, from 15% to 25% methyl palmitate, from 10% to 15% methyl stearate, from 2% to 7% methyl myristate, from 2% to 6% methyl pentadecanoate and from 1% to 3% methyl laurate; or - from 30% to 40% of methyl linoleate, from 25% to 35% of methyl oleate, from 15% to 25% of methyl palmitate, from 5% to 15% of 2-(2-butoxyethoxy)ethanol, from 2% to 6% of dimethyl glutarate, from 1% to 3% of dimethyl adipate, from 1% to 3% of dimethyl succinate and from 1% to 3% of dodecane; or - from 25% to 35% methyl oleate, from 25% to 35% methyl palmitate, from 25% to 35% methyl linoleate, from 3% to 7% methyl stearate, from 3% to 5% methyl myristate and from 0.5% to 2% methyl pentadecanoate; or - 30% to 40% methyl oleate, 20% to 26% methyl linoleate, 20% to 26% methyl palmitate, 6% to 10% squalene, 2% to 6% methyl myristate and 3% to 5% of methyl pentadecanoate; or - from 62% to 70% of methyl oleate, from 12% to 16% of methyl palmitate, from 7% to 13% of dimethyl pimelate and from 6% to 11% of dimethyl azelate; or - from 2% to 6% of methyl laurate, from 2% to 6% of methyl myristate, from 1% to 5% of methyl palmitate, from 2% to 6% of methyl stearate, from 42% to 50% of methyl oleate, from 4% to 8% of methyl linoleate, from 7% to 13% of dimethyl pimelate and from 6% to 11% of dimethyl azelate; or - from 40% to 60% of 3-cyclopentyl propionic acid and from 40% to 60% of 3-cyclohexyl propionic acid; or - from 40% to 60% of bis(2-ethylhexyl) adipate and from 40% to 60% of l-isopropyl-2,2-dimethyltrimethylene diisobutyrate, - from 35% to 45% by weight of methyl oleate, from 20% to 30% by weight of methyl palmitate, from 20% to 30% by weight of methyl linoleate, from 2% to 7% by weight of dioxolane, from 1% to 5% by weight of methyl laurate and from 1% to 4% by weight of methyl myristate;the total sum of the compounds present in said semiochemical composition being equal to 100%;

4. Composition in the form of an oil-in-water (O / W) emulsion according to any one of claims 1 to 3, characterized in that said at least one humectant is chosen from polyols selected from the group consisting of glycerol, propylene glycol, polyethylene glycols (PEG), xylitol, isomalt, maltitol, mannitol, polydextrose, sorbitol, isomaltitol, lactitol, and mixtures thereof; and / or said at least one humectant is chosen from sugars selected from the group consisting of fructose, glucose, lactose; preferably said at least one humectant is glycerol.

5. Composition in the form of an oil-in-water (O / W) emulsion according to any one of claims 1 to 4, characterized in that said at least one humectant is present in a content ranging from 4% to 12% by weight, preferably from 4% to 6% by weight, relative to the total weight of the composition.

6. Composition in the form of an oil-in-water (O / W) emulsion according to any one of claims 1 to 5, characterized in that it comprises from 60% to 95% by weight of water, preferably from 77% to 87% by weight of water, relative to the total weight of the composition, and / or in that it comprises from 1% to 4% by weight, preferably from 1.5% to 2.5% by weight of said semiochemical composition, relative to the total weight of the composition.

7. Composition in the form of an oil-in-water (O / W) emulsion according to any one of claims 1 to 6, characterized in that said at least one emollient agent is chosen from the group consisting of hydrogenated vegetable oils, silicone oils, mineral oils and waxes, fatty alcohols, fatty acids and fatty acid esters, glyceride derivatives, and glycerol derivatives, preferably glyceride derivatives.

8. Composition in the form of an oil-in-water (O / W) emulsion according to any one of claims 1 to 7, characterized in that said at least one emollient agent is present in a content ranging from 0.5% to 8% by weight, preferably from 1% to 3% by weight, relative to the total weight of the composition.

9. Composition in the form of an oil-in-water (O / W) emulsion according to any one of claims 1 to 8, characterized in that said at least one emulsifying agent is chosen from fatty acid esters of polyoxyethylene sorbitan, fatty acid esters of polyols or ethoxylated vegetable oils, preferably hydrogenated and ethoxylated.

10. Composition in the form of an oil-in-water (O / W) emulsion according to any one of claims 1 to 9, characterized in that said at least one emulsifying agent is present in a content ranging from 1% to 25% by weight, preferably from 5% to 7% by weight, relative to the total weight of the composition.

11. Composition in the form of an oil-in-water (O / W) emulsion according to any one of claims 1 to 10, characterized in that the oily phase further comprises at least one additive chosen from the group consisting of a preservative, in particular an antimicrobial agent or an antioxidant agent, a perfume, a masking agent, and mixtures thereof.

12. Composition in the form of an oil-in-water (O / W) emulsion according to any one of claims 1 to 11, characterized in that it is administered in the form of a mist, in particular using a sprayer.

13. Composition in the form of an oil-in-water (O / W) emulsion according to any one of claims 1 to 12, characterized in that it comprises: a) an aqueous phase comprising water and glycerol, b) an oily phase comprising polyglyceryl-3 distearate, PEG-40 hydrogenated castor oil, polyoxyethylene sorbitan fatty acid esters, caprylic and capric acid triglycerides, Glycerin / phenyl alcohol / caprylhydroxamic acid, pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate, an optional perfume, and a semiochemical composition, the semiochemical composition being present in the composition in the form of an oil-in-water emulsion in a content ranging from 1% to 4% by weight, preferably from 1.5% to 2.5% by weight, relative to the total weight of the composition.

14. A process for preparing a composition in the form of an oil-in-water (O / W) emulsion according to any one of claims 1 to 13, comprising the following steps: a) said at least one gelling agent is pasted into said at least one humectant; then water is added with stirring and at a temperature between 65°C and 75°C, preferably at a temperature of 70°C, so as to obtain a homogeneous aqueous phase; b) mixing said at least one emollient agent, said at least one emulsifying agent, said semiochemical composition and optionally said at least one additive, with stirring and at a temperature between 65°C and 75°C, preferably at a temperature of 70°C, so as to obtain a homogeneous oily phase; c) the oily phase from step b) is added with stirring to the aqueous phase from step a) so as to obtain an oil-in-water (O / W) emulsion; d) optionally the pH of the emulsion obtained in step c) is adjusted; e) optionally add a perfume; f) the composition is recovered in the form of an oil-in-water (O / W) emulsion obtained in step c), d) or e).

15. Method according to claim 14, characterized in that: - the mashing step a) is carried out at room temperature; and / or - the homogeneous aqueous phase obtained in step a) is kept stirring at a temperature between 65°C and 75°C, preferably at a temperature of 70°C; and / or - the homogeneous oily phase obtained in step b) is kept stirring at a temperature between 65°C and 75°C, preferably at a temperature of 70°C; and / or - step c) is carried out by mixing the oily phase from step b) in the aqueous phase of step a) at a temperature between 65°C and 75°C, preferably at a temperature of 70°C, and the emulsion is cooled to room temperature; and / or - step d) is carried out by adding a basic solution, for example a NaOH solution.

16. Non-therapeutic use of a composition in the form of an oil-in-water (O / W) emulsion according to any one of claims 1 to 13, for administration, in particular by spraying using a mist sprayer, onto the skin of an animal or a human, or onto the skin of farm animals treated in groups, or onto textiles and / or objects and / or walls, or by spraying into the air, in particular near the nose of an animal or a human.