Cosmetic composition with antiglycation effect to improve skin resistance to aging

Abstract

Cosmetic composition with antiglycation effect for improving skin resistance to aging A cosmetic composition for combating skin aging, particularly on the neck, includes a blend of skin actives comprising vitamin C, a vitamin C derivative, or a combination thereof; a dandelion root extract; and at least one additional active selected from the group consisting of caffeine, vitamin E, lavender oil, and combinations thereof; and an aqueous carrier system comprising water, wherein the cosmetic composition inhibits the glycation of peptides and proteins. The skin actives are provided in an aqueous carrier in the form of a monophase, a biphase, or an emulsion wherein the cosmetic composition is a leave-on treatment in the form of a cream, a gel, a lotion, a tonic, or a serum. Figure for abstract: none

Description

Title of the invention: Cosmetic composition with antiglycation effect to improve the skin's resistance to aging FIELD OF THE INVENTION

[0001] The present disclosure relates to a water-based cosmetic composition for combating skin aging which includes a mixture of skin actives which inhibit the glycation of peptides and proteins. CONTEXT OF THE INVENTION

[0002] Skin aging and the associated visible and textural changes are the primary targets of a wide variety of cosmetic products. The skin of the face and neck are particularly important targets for such treatments, particularly the skin of the neck which has different physical characteristics than the skin of the face and, therefore, exhibits particular signs of aging, which may include fine lines, wrinkles, sagging and sagging. Among skin cleansers, toners, moisturizers and other forms of treatment, a wide variety of skin care products offer blends of ingredients that address the signs of aging.Although many of the ingredients in these products are known to have significant biological effects, it is difficult to provide cosmetic treatments that include sufficient amounts and combinations of these ingredients to be effective.

[0003] A particular aspect of skin aging is the accumulation of advanced glycation end products (sometimes referred to as "AGEs" in the cosmetic literature) in the skin, which is involved in the skin aging process related to collagen degradation (correlated with loss of skin firmness) and melanogenesis (correlated with loss of skin tone uniformity). Active ingredients with antiglycation activity are known, including, for example, aminoguanidine (also known as gallic acid, extracted from hazelnut skins), alisine (extracted from garlic) and carnosine (also known as beta-alanyl-L-histidine, a dipeptide present in mammals); however, these actives are not always suitable for all cosmetic vehicles due to ingredient incompatibility, cost and negative impact on the aesthetics of the cosmetic product.

[0004] The present invention provides a novel combination of active ingredients exhibiting an unexpected antiglycation effect that is synergistic in nature, wherein none of the individual active ingredients possess antiglycation activity at practical use levels, but the combination demonstrates statistically significant inhibition of peptide and protein glycation. BRIEF SUMMARY OF THE INVENTION

[0005] In a first embodiment, the disclosure provides a cosmetic composition that includes a blend of skin actives comprising vitamin C, a vitamin C derivative, or a combination thereof; a dandelion root extract; and at least one additional active selected from the group consisting of caffeine, vitamin E and its derivatives, lavender oil, and combinations thereof; and an aqueous carrier system comprising water, wherein the cosmetic composition inhibits the glycation of peptides and proteins.

[0006] In some embodiments, the vitamin C, vitamin C derivative, or combination thereof is present in an amount of about 0.2% to about 50%, the dandelion root extract is present in an amount of about 0.05% to about 5%, and each of the at least one additional active is present in an amount of about 0.01% to about 5%, all percentages being by weight, based on the total weight of the cosmetic composition.

[0007] In some embodiments, the vitamin C, vitamin C derivative, or combination thereof is present in an amount of about 0.2% to about 10%, the dandelion root extract is present in an amount of about 0.08% to about 3%, and each of the at least one additional active is present in an amount of about 0.01% to about 1%, all percentages being by weight, based on the total weight of the cosmetic composition.

[0008] In some embodiments, the at least one additional active ingredient comprises caffeine present in an amount of about 0.05% to about 0.5%, by weight, relative to the total weight of the cosmetic composition.

[0009] In some embodiments, the at least one additional active ingredient comprises vitamin E present in an amount of about 0.05% to about 0.5%, by weight, relative to the total weight of the cosmetic composition.

[0010] In some embodiments, the at least one additional active ingredient comprises lavender oil present in an amount of about 0.010% to about 0.020%, by weight, relative to the total weight of the cosmetic composition.

[0011] In some embodiments, the vitamin C, vitamin C derivative, or combination thereof is selected from the group consisting of 1-ascorbic acid, acetyl-C (3-O-ethylascorbic acid), magnesium ascorbyl phosphate, sodium ascorbyl phosphate, tetrahexyldecyl ascorbate, ascorbyl glucoside, and combinations thereof.

[0012] In some embodiments, the vitamin C, vitamin C derivative, or combination thereof comprises acetyl-C, and the at least one additional active comprises caffeine, vitamin E and its derivatives, and lavender oil.

[0013] In some embodiments, the cosmetic composition is a single-phase, two-phase, or emulsion, and wherein the cosmetic composition is a leave-on treatment in the form of a cream, gel, lotion, toner, or serum.

[0014] In some embodiments, the cosmetic composition includes at least one additive selected from the group consisting of solvents, surfactants, thickeners, oils, waxes, preservatives, brighteners, effect pigments, essential oils, plant extracts, cosmetic actives, and combinations thereof.

[0015] In some embodiments, the cosmetic composition includes: at least one water-soluble solvent selected from the group consisting of denatured alcohol, glycerin, propylene glycol, pentylene glycol, PEG / PPG / polybutylene glycol-8 / 5 / 3 glycerin, propanediol, butylene glycol, and combinations thereof; at least one thickener selected from the group consisting of hydroxyethylcellulose, xanthan gum, hydroxypropylcellulose, sclerotium gum, guar gum, acacia gum, gellan gum, hydroxypropyl guar, and combinations thereof; at least one surfactant selected from the group consisting of PPG-6-decyltetradeceth-30, PEG-60 hydrogenated castor oil, laureth-23, polyglyceryl-2-oleate, polyglyceryl-4-caprate and combinations thereof;at least one cosmetic active ingredient selected from the group consisting of adenosine, citric acid, hydroxypropyltetrahydropyrantriol, methyl dihydrojasmonate, phenoxyethanol, potassium hydroxide, salicylic acid, sodium citrate, tetrasodium glutamate diacetate, peptides, niacinamide, camosine, and combinations thereof.;

[0016] In another embodiment, the disclosure provides a cosmetic composition that includes vitamin C, a vitamin C derivative, or a combination thereof; a dandelion root extract; caffeine; vitamin E and its derivatives; and lavender oil; an aqueous carrier system comprising water and at least one additive selected from the group consisting of: at least one water-soluble solvent selected from the group consisting of denatured alcohol, glycerin, propylene glycol, PEG / PPG / polybutylene glycol-8 / 5 / 3 glycerin, pentylene glycol, propanediol, butylene glycol, and combinations thereof; at least one thickener including hydroxyethylcellulose; at least one surfactant selected from the group consisting of PPG-6-decyltetradeceth-30, PEG-60 hydrogenated castor oil, laureth-23, polyglyceryl-2-oleate, polyglyceryl-4-caprate and combinations thereof;at least one cosmetic active ingredient chosen from the group consisting of adenosine, citric acid, hydroxypropyltetrahydropyrantriol, methyl dihydrojasmonate, phenoxyethanol, potassium hydroxide, salicylic acid, sodium citrate, ; tetrasodium glutamate diacetate, peptides, niacinamide, camosine, and combinations thereof; and combinations thereof, wherein the cosmetic composition inhibits the glycation of peptides and proteins, and wherein the cosmetic composition is a single-phase, two-phase, or emulsion, and wherein the cosmetic composition is a leave-on treatment in the form of a cream, gel, lotion, toner, or serum.

[0017] In some embodiments, the vitamin C, a vitamin C derivative, or a combination thereof is acetyl-C.

[0018] In some embodiments, acetyl-C is present in an amount of about 0.2% to about 10% by weight, based on the total weight of the cosmetic composition; dandelion root extract is present in an amount of about 0.08% to about 3% by weight, based on the total weight of the cosmetic composition; caffeine is present in an amount of about 0.05% to about 1% by weight, based on the total weight of the cosmetic composition; vitamin E is present in an amount of about 0.05% to about 1% by weight, based on the total weight of the cosmetic composition; lavender oil is present in an amount of about 0.01% to about 1% by weight, based on the total weight of the cosmetic composition.

[0019] In some embodiments, the at least one water-soluble solvent comprises alcohol, glycerin, propylene glycol, PEG / PPG / polybutylene glycol-8 / 5 / 3 glycerin, and pentylene glycol; the at least one thickener comprises hydroxyethylcellulose; the at least one surfactant comprises PPG-6-decyltetradeceth-30; the at least one additional active comprises adenosine, citric acid, hydroxypropyltetrahydropyrantriol, methyl dihydrojasmonate, phenoxyethanol, potassium hydroxide, salicylic acid, sodium citrate, and tetrasodium glutamate diacetate.

[0020] In some embodiments of the cosmetic composition, acetyl-C is present in an amount of about 0.2% to about 1.5%, dandelion root extract is present in an amount of about 0.08% to about 3%, caffeine is present in an amount of about 0.05% to about 0.5%, vitamin E is present in an amount of about 0.05% to about 0.5%, and lavender oil is present in an amount of about 0.010% to about 0.020%, all percentages being by weight, based on the total weight of the cosmetic composition, and wherein the cosmetic composition is provided in the form of an emulsion and is a leave-on treatment in the form of a cream, gel, lotion, tonic, or serum, and wherein the cosmetic composition inhibits the glycation of peptides and proteins.

[0021] In some embodiments of the cosmetic composition, acetyl-C is present at about 1%, dandelion root extract is present at about 0.13%, caffeine is present at about 0.1%, vitamin E is present in an amount of about 0.1%, and lavender oil is present in an amount of about 0.015%, all percentages being by weight, based on the total weight of the cosmetic composition, and wherein the cosmetic composition is provided in the form of an emulsion and is a leave-on treatment in the form of a cream, gel, lotion, tonic or serum, and wherein the cosmetic composition inhibits the glycation of peptides and proteins.

[0022] In some embodiments of the cosmetic composition, acetyl-C is present at about 5%, dandelion root extract is present at about 0.22%, caffeine is present at about 0.5%, vitamin E is present at about 0.5%, and lavender oil is present at about 0.08%, all percentages being by weight, based on the total weight of the cosmetic composition, and wherein the cosmetic composition is provided in the form of an emulsion and is a leave-on treatment in the form of a cream, gel, lotion, tonic, or serum, and wherein the cosmetic composition inhibits the glycation of peptides and proteins.

[0023] In some embodiments of the cosmetic composition, acetyl-C is present at about 10%, dandelion root extract is present at about 1.3%, caffeine is present at about 1%, vitamin E is present at about 1%, and lavender oil is present at about 0.15%, all percentages being by weight, based on the total weight of the cosmetic composition, and wherein the cosmetic composition is provided in the form of an emulsion and is a leave-on treatment in the form of a cream, gel, lotion, tonic, or serum, and wherein the cosmetic composition inhibits the glycation of peptides and proteins.

[0024] In another embodiment, the disclosure provides a method of enhancing a keratinous substrate, the method including providing a leave-on cosmetic composition that includes: vitamin C, a vitamin C derivative, or a combination thereof; dandelion root extract; caffeine; vitamin E; lavender oil; and an aqueous carrier system comprising water; and optionally, an additive selected from the group consisting of: a water-soluble solvent selected from the group consisting of denatured alcohol, glycerin, propylene glycol, PEG / PPG / polybutylene glycol-8 / 5 / 3 glycerin, pentylene glycol, propanediol, butylene glycol, and combinations thereof;at least one thickener selected from the group consisting of hydroxyethylcellulose, xanthan gum, hydroxypropylcellulose, sclerotium gum, guar gum, acacia gum, gellan gum, hydroxypropyl guar, and combinations thereof; a surfactant selected from the group consisting of PPG-6-decyltetradeceth-30, PEG-60 hydrogenated castor oil, laureth-23, polyglyceryl-2-oleate, polyglyceryl-4-; caprate and combinations thereof; a cosmetic active selected from the group consisting of adenosine, citric acid, hydroxypropyltetrahydropyrantriol, methyl dihydrojasmonate, phenoxyethanol, potassium hydroxide, salicylic acid, sodium citrate, tetrasodium glutamate diacetate, peptides, niacinamide, carnosine, and combinations thereof; and combinations thereof; applying the cosmetic composition to the keratinous substrate at least twice daily, for one or more days and, in some examples, for a period of at least 10 days0; wherein the cosmetic composition inhibits the glycation of peptides and proteins, and wherein the cosmetic composition is a single-phase, two-phase or emulsion, and wherein the cosmetic composition is a leave-on treatment in the form of a cream, gel, lotion, tonic or serum.

[0025] These and other aspects of the invention are set forth in the appended claims and described in more detail in the detailed description of the invention.

[0026] The present disclosure describes exemplary embodiments in accordance with the general inventive concepts and is not intended to limit the scope of the invention in any way. Indeed, the invention as described in the patent specification extends beyond and is not limited to the exemplary embodiments presented herein, and the terms used herein have their full ordinary meaning. DETAILED DESCRIPTION OF THE INVENTION

[0027] “Keratinous substrate” as used herein includes, but is not limited to, tissues keratinous, such as facial and body skin, hair and nails.

[0028] The disclosure relates to a cosmetic composition for combating skin aging which includes a mixture of skin actives comprising vitamin C, a vitamin C derivative, or a combination thereof; a dandelion root extract; and at least one additional active selected from the group consisting of caffeine, vitamin E and its derivatives, lavender oil, and combinations thereof; and an aqueous carrier system comprising water, wherein the cosmetic composition inhibits the glycation of peptides and proteins. The skin actives are provided in an aqueous carrier in the form of a single phase, a two-phase or an emulsion wherein the cosmetic composition is a leave-on treatment in the form of a cream, gel, lotion, toner or serum.

[0029] The cosmetic composition demonstrates a statistically significant inhibition of peptide and protein glycation, as demonstrated in in tubo (in vitro) experiments. Since peptide and protein glycation has been shown to impact skin quality and contribute to the signs of aging, the cosmetic composition is useful for combating skin aging, including wrinkles, fine lines, sagging and sagging, wherein the benefits that may be conferred may include one or more of increased firmness, increased elasticity, improved hydration, and reduced presence of superficial fatty tissue.

[0030] In various embodiments, the cosmetic composition comprises the following ingredients and additional optional ingredients. COMPOSITIONS Vitamin C / Derivatives

[0031] In various embodiments, the cosmetic composition includes vitamin C, a vitamin C derivative, or a combination thereof.

[0032] In some embodiments, the vitamin C, vitamin C derivative, or combination thereof is selected from the group consisting of 1-ascorbic acid, acetyl-C (3-O-ethylascorbic acid), magnesium ascorbyl phosphate, sodium ascorbyl phosphate, tetrahexyldecyl ascorbate, ascorbyl glucoside, and combinations thereof.

[0033] In some embodiments, the vitamin C, vitamin C derivative, or a combination thereof comprises a vitamin C derivative that comprises acetyl-C (3-O-ethylascorbic acid). In some embodiments, the vitamin C, vitamin C derivative, or a combination thereof comprises the vitamin C derivative that consists of acetyl-C (3-O-ethylascorbic acid).

[0034] The cosmetic composition comprises vitamin C, a vitamin C derivative, or a combination thereof in an amount of from about 0.2% to about 50%, or from about 0.2% to about 10%, or from about 0.5% to about 1.5%, or from about 50%, or from about 10%, or from about 5%, or from about 1%, or any suitable combination, subcombination, range, or subrange of these values ​​by weight, based on the weight of the cosmetic composition. However, those skilled in the art will understand that other ranges are within the scope of the invention.

[0035] Thus, vitamin C or a vitamin C derivative, or a combination thereof is present by weight, relative to the total weight of the cosmetic composition, in an amount of approximately 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 25, 30, 35, 40, 45, to approximately 50 percent, including increments and intermediate ranges. Dandelion root extract

[0036] In various embodiments, the cosmetic composition includes a dandelion root extract (TARAXACUM OFFICINALE (DANDELION) RHIZOME / ROOT EXTRACT). A commercially available example of a dandelion root extract is APOLLUSKIN GRV - supplied by Silab.

[0037] The cosmetic composition comprises a dandelion root extract in an amount of from about 0.05% to about 50%, or from about 0.05% to about 5%, or from about 0.08% to about 3%, or from about 0.08% to about 1.5%, or from about 0.08% to about 0.18%, or from about 0.13%, or from about 0.22%, or from about 1.3%, or from about 2.2%, or from about 3%, or any suitable combination, subcombination, range or subrange of these values ​​by weight, based on the weight of the cosmetic composition. However, those skilled in the art will understand that other ranges are within the scope of the invention.

[0038] Thus, the dandelion root extract is present, by weight, relative to the total weight of the cosmetic composition in an amount of approximately 0.05, 0.06, 0.07, 0.08, 0.09, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 25, 30, 35, 40, 45, to about 50 percent, including intermediate increments and ranges. Additional additives

[0039] In various embodiments, the cosmetic composition includes at least one additional active selected from the group consisting of caffeine, vitamin E (and its derivatives, including tocopheryl acetate, tocopheryl glucoside, tocopheryl phosphate, tocopheryl succinate, alpha-, beta-, gamma-, and delta-tocopherol, and alpha-, beta-, gamma-, and delta-tocotrienol), lavender oil (LAVANDULA ANGUSTIFOLIA (LAVENDER) OIL), and combinations thereof. In some embodiments, the cosmetic composition includes as additional actives caffeine, vitamin E, and lavender oil.

[0040] In various embodiments, the cosmetic composition comprises each of the additional actives present in a range of from about 0.01% to about 50%, or from about 0.01% to about 10%, or from about 0.01% to about 5%, or from about 0.01% to about 1%, or any suitable combination, subcombination, range or subrange of these values ​​by weight, based on the weight of the cosmetic composition.

[0041] In various embodiments, the cosmetic composition comprises caffeine, if any, in a range of about 0.01% to about 50%, or about 0.01% to about 10%, or about 0.01% to about 5%, or about 0.01% to about 1%, or about 0.05% to about 1%, or about 0.05% to about 0.5%, or at about 0.1%, or about 0.5% or about 1%, or about any suitable combination, subcombination, range or subrange of these values ​​by weight, based on the weight of the cosmetic composition.

[0042] In various embodiments, the cosmetic composition comprises vitamin E or a derivative thereof, where appropriate, in a range of about 0.01% to about 50%, or about 0.01% to about 10%, or about 0.01% to about 5%, or about 0.01% to about 1%, or about 0.05% to about 1%, or from about 0.05% to about 0.5%, or at a rate of about 0.1%, or about 0.5%, or about 1%, or about any suitable combination, subcombination, range or subrange of these values ​​by weight, based on the weight of the cosmetic composition.

[0043] In various embodiments, the cosmetic composition comprises lavender oil, if applicable, in a range of about 0.01% to about 50%, or about 0.01% to about 10%, or about 0.01% to about 5%, or about 0.01% to about 1%, or about 0.05% to about 0.5%, or about 0.010% to about 0.020%, or about 0.015%, or about 0.08%, or about 0.15%, or any suitable combination, subcombination, range or subrange of these values ​​by weight, based on the weight of the cosmetic composition.

[0044] Thus, each of the at least one additional active ingredient may be present by weight, relative to the total of the cosmetic composition, at a rate of approximately 0.01, 0.015, 0.02, 0.025, 0.03, 0.035, 0.04, 0.045, 0.05, 0.055, 0.06, 0.065, 0.07, 0.075, 0.08, 0.085, 0.09, 0.095, 0.1, 0.15, 0.2, 0.25, 0.3, 0.35, 0.4, 0.45, 0.5, 0.55, 0.6, 0.65, 0.7, 0.75, 0.8, 0.85, 0.9, 0.95, 1.0, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 25, 30, 35, 40, 45, to approximately 50 percent, including intermediate increments and ranges. Aqueous carrier system Water

[0045] In various embodiments, the cosmetic composition includes water. The cosmetic composition comprises from about 1% to about 99% water, or from about 10% to about 95%, or from about 15% to about 90%, or from about 40% to about 80%, or from about 45% to about 65%, or from about 55% to about 70%, or about 60% or any suitable combination, subcombination, range or subrange of these values ​​by weight, based on the weight of the cosmetic composition. However, those skilled in the art will understand that other ranges are within the scope of the invention.

[0046] Thus, water is present by weight, relative to the total weight of the cosmetic composition, in an amount of about 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95 to about 99 percent, including intermediate increments and ranges.

[0047] The pH of the cosmetic composition is not limited, but is generally greater than or equal to about pH 6 and, in some embodiments, is one between 5 and 8, and between 5 and 7, and between 6 and 7 and, in some embodiments is about 6. The pH may be corrected to the desired value by the addition of a base (organic or inorganic) to the cosmetic composition, for example ammonia or a primary, secondary or tertiary (poly)amine, such as monoethanolamine, diethanolamine, triethanolamine, isopropanolamine or 1,3-propanediamine, or alternatively by the addition of an inorganic or organic acid, advantageously a carboxylic acid, such as, for example, citric acid. Water-soluble solvents

[0048] In some embodiments, the cosmetic composition may include at least one water-soluble solvent. The term "water-soluble solvent" is interchangeable with the term "water-miscible solvent" and refers to a compound that is liquid at 25°C and atmospheric pressure (760 mmHg), and that has a solubility of at least 50% in water under these conditions. In some cases, the water-soluble solvent has a solubility of at least 60%, 70%, 80%, or 90% in water under these conditions. Non-limiting examples of water-soluble solvents include, for example, glycerin, alcohols (e.g., C1-C30, C1-C15, C1-C10, or C1-C4 alcohols), organic solvents, polyols, glycols, or mixtures thereof.

[0049] In certain particular embodiments according to the disclosure, where appropriate, a water-soluble solvent may include alcohol (denatured alcohol), glycerin, propylene glycol and pentylene glycol, or combinations thereof.

[0050] Examples of organic solvents that may be mentioned, without limitation, are monoalcohols and polyols such as ethyl alcohol, isopropyl alcohol, propyl alcohol, benzyl alcohol and phenylethyl alcohol, or glycols or glycol ethers such as, for example, monomethyl-, monoethyl- and monobutyl-ethers of ethylene glycol, propylene glycol or their ethers such as, for example, monomethyl ethers of propylene glycol, butylene glycol, hexylene glycol, dipropylene glycol as well as alkyl ethers of diethylene glycol, for example, monoethyl ether or monobutyl ether of diethylene glycol. Other suitable examples of organic solvents are ethylene glycol, propylene glycol, butylene glycol, hexylene glycol, propanediol and glycerin. Organic solvents can be volatile or non-volatile compounds.

[0051] Other non-limiting examples of water-soluble solvents include alkanols (polyhydric alcohols such as glycols and polyols) such as glycerin, 1,2,6-hexanetriol, trimethylolpropane, ethylene glycol, propylene glycol, diethylene glycol, butylene glycol, hexylene glycol, triethylene glycol, tetraethylene glycol, pentaethylene glycol, dipropylene glycol, 1,3-butanediol, 2,3-butanediol, 1,4-butanediol, 3-methyl-1,3-butanediol, 1,5-pentanediol, tetraethylene glycol, 1,6-hexanediol, 2-methyl-2,4-pentanediol, polyethylene glycol, 1,2,4-butanetriol, 1,2,6-hexanetriol, 2-butene-1,4-diol, 2-ethyl-1,3-hexanediol, 2-methyl-2,4-pentanediol, (caprylyl glycol), 1,2-hexanediol, 1,2-pentanediol and 4-methyl-1,2-pentanediol; alkyl alcohols having 1 to 4 carbon atoms such as ethanol, methanol, butanol, propanol and isopropanol; glycol ethers such as ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, ethylene glycol monomethyl ether acetate, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol mono-n-propyl ether, ethylene glycol mono-iso-propyl ether, diethylene glycol mono-iso-propyl ether, ethylene glycol mono-n-butyl ether, ethylene glycol mono-t-butyl ether, diethylene glycol mono-t-butyl ether, 1-methyl-l-methoxybutanol, propylene glycol monomethyl ether, propylene glycol monoethyl ether, propylene glycol mono-t-butyl ether, propylene glycol mono-n-propyl ether, propylene glycol mono-iso-propyl ether, dipropylene glycol monomethyl ether, dipropylene glycol monoethyl ether, dipropylene glycol mono-n-propyl ether and dipropylene glycol mono-iso-propyl ether;2-pyrrolidone, N-methyl-2-pyrrolidone, 1,3-dimethyl-2-imidazolidinone, formamide, acetamide, dimethyl sulfoxide, sorbitol, sorbitan, acetin, diacetin, triacetin, sulfolane, or mixtures thereof. ;

[0052] In various embodiments, the amount of the at least one water-soluble solvent, if any, is from about 0.1% to about 25%, or from about 0.1% to about 2%, or from about 0.1% to about 1%, or from about 0.1% to about 0.8%, or from about 0.1% to about 0.5%, or from about 1% to about 20%, or from about 1% to about 10%, or from about 2% to about 8%, or any suitable combination, subcombination, range, or subrange of these values ​​by weight, based on the weight of the cosmetic composition. A person skilled in the art will, however, understand that other ranges are within the scope of the invention. In some embodiments, the cosmetic composition includes more than one water-soluble solvent, each water-soluble solvent being present in an amount as indicated above, wherein each different water-soluble solvent may be present in one of the ranges selected from the ranges indicated above.

[0053] Thus, each water-soluble solvent or combination of water-soluble solvents, if any, may be present by weight, based on the total weight of the cosmetic composition, in an amount of about 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24 to about 25 percent by weight, including increments and ranges therein. Additional Ingredients / Additives

[0054] In certain embodiments, the cosmetic composition may include at least one additive selected from the group consisting of solvents, thickeners, surfactants, cosmetic actives, preservatives, oils, waxes, essential oils, plant extracts, pH correctors, chelating agents, dispersants, brighteners, pigments, effect pigments, dyes and colorants, powders, opacifiers, and combinations thereof.

[0055] In certain particular embodiments, the cosmetic composition includes additives selected from the group consisting of a water-soluble solvent selected from the group consisting of denatured alcohol, glycerin, propylene glycol, PEG / PPG / polybutylene glycol-8 / 5 / 3 glycerin, pentylene glycol, propanediol, butylene glycol, and combinations thereof; at least one thickener selected from the group consisting of hydroxyethylcellulose, xanthan gum, hydroxypropylcellulose, sclerotium gum, guar gum, acacia gum, gellan gum, hydroxypropyl guar, and combinations thereof; at least one surfactant selected from the group consisting of PPG-6-decyltetradeceth-30, PEG-60 hydrogenated castor oil, laureth-23, polyglyceryl-2-oleate, polyglyceryl-4-caprate and combinations thereof;at least one cosmetic active ingredient selected from the group consisting of adenosine, citric acid, hydroxypropyltetrahydropyrantriol, methyl dihydrojasmonate, phenoxyethanol, potassium hydroxide, salicylic acid, sodium citrate, tetrasodium glutamate diacetate, peptides, niacinamide, camosine, and combinations thereof.; Thickening

[0056] In some embodiments, the cosmetic composition may include one or more thickeners. The thickener may be synthetic, inorganic, or organic in nature, and may comprise a particle of any shape.

[0057] In certain embodiments according to the disclosure, where appropriate, a thickener may be hydroxyethylcellulose.

[0058] More generally, by way of non-limiting example, the thickeners may be chosen from xanthan gum, cellulose gum, acacia Senegal gum, guar gum, sclerotium gum, dehydroxanthan gum, gellan gum, agar, algin, talc, mica, silica, silica surface-treated with a hydrophobic agent, fumed silica, kaolin, clay / mineral smectite powders (Argilla extract), polyamide (NYLON) (for example, ORGASOL from Atochem), polyurethane powders, a poly-[3-alanine powder and a polyethylene powder, tetrafluoroethylene polymer powders (TEFLON), lauroyllysine, a starch, boron nitride, hydrophobic silica aerogel particles, microspheres hollow polymers such as those made of polyvinylidene chloride / acrylonitrile,for example EXPANCEL (Nobel Industrie) or acrylic acid copolymers (POLYTRAP from Dow Corning) and silicone resin microbeads (TOSPEARLS from Toshiba, for example), elastomeric polyorganosiloxane particles, precipitated calcium carbonate, magnesium carbonate, magnesium hydrogen carbonate, hydroxyapatite, hollow silica microspheres (SILICA BEADS from Maprecos), glass or ceramic microcapsules and metallic soaps derived from organic carboxylic acids containing from 8 to 22 carbon atoms and preferably from 12 to 18 carbon atoms, for example zinc stearate, magnesium stearate, lithium stearate, zinc laurate, magnesium myristate and combinations thereof.

[0059] In some embodiments, one or more thickeners may be present in the cosmetic composition in an amount of from about 0.01% to about 10%, or from about 0.01% to about 5%, or from about 0.01% to about 1%, or from about 0.01% to about 0.2%, or from about 0.01% to about 0.09%, or from about 0.02% to about 0.08%, or any suitable combination, subcombination, range, or subrange of these values ​​by weight, based on the weight of the cosmetic composition. However, those skilled in the art will understand that other ranges are within the scope of the invention. In some embodiments, the cosmetic composition includes more than one thickener, each thickener being present in an amount as set forth above, wherein each different thickener may be present in one of the ranges selected from the ranges set forth above.

[0060] Thus, each thickener or combination of thickeners, if any, may be present by weight, based on the total weight of the cosmetic composition, in an amount of about 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 2, 3, 4, 5, 6, 7, 8, 9, to about 10 percent, including intermediate increments and ranges. Surfactant

[0061] In some embodiments, the cosmetic composition may include one or more surfactants. In some particular embodiments, the cosmetic composition may comprise an emulsion that comprises one or more surfactants, alone or in combination, with one or more oils (as described below).

[0062] In certain particular embodiments according to the disclosure, where appropriate, a surfactant may include PPG-6-decyltetradeceth-30.

[0063] By way of non-limiting example, the surfactants may be selected from glyceryl stearate (e.g., glyceryl stearate SE), stearic acid, potassium cetyl phosphate, and combinations thereof.

[0064] The one or more surfactants in the cosmetic composition may be present in an amount ranging from about 0.1% to about 5%, or from about 0.1% to about 1%, or from about 0.2% to about 0.8%, or from about 0.3% to about 0.5%. In at least some exemplary embodiments, the surfactant is present in an amount less than about 1%, or less than about 0.8%. In some embodiments, the cosmetic composition includes more than one surfactant, each surfactant being present in an amount as set forth above, wherein each different surfactant may be present in any of the ranges selected from the ranges stated above.

[0065] Thus, each surfactant or combination of surfactants, if any, may be present by weight, based on the total weight of the cosmetic composition, in an amount of about 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2, 3, 4, to about 5 percent, including intermediate increments and ranges. Oil

[0066] In some embodiments, the cosmetic composition may include one or more oils. In some embodiments, the cosmetic composition may comprise an emulsion that comprises one or more oils, alone or in combination, with one or more surfactants (as described above).

[0067] In some embodiments, the cosmetic composition may include Cymbopogon Martini Oil, or Lavender Oil (as an additional active), or a combination thereof.

[0068] As used herein, oil refers to any non-polar compound that is liquid at 25°C and is hydrophobic and lipophilic. An oil suitable for the present use may be volatile or non-volatile. The term "volatile oil" refers to an oil that can evaporate upon contact with the skin or a keratin fiber in less than one hour, at room temperature and atmospheric pressure. The volatile oil or oils is (are) liquid at room temperature and has a non-zero vapor pressure, at room temperature and atmospheric pressure, in particular ranging from 0.13 Pa to 40,000 Pa (10-3 to 300 mmHg). The term "non-volatile oil" refers to an oil that remains on the skin or keratin fiber, at room temperature and atmospheric pressure, for at least several hours and in particular has a vapor pressure of less than 10-3 mmHg (0.13 Pa).

[0069] In some embodiments, by way of non-limiting example, the one or more oils in the cosmetic composition may be selected from botanical and essential oils, such as Helianthus annuus seed oil, Mentha piperita oil, Rosmarinus officinalis (rosemary) leaf oil, Pelargonium graveolens flower oil, Citrus aurantium dulcis (orange) peel oil, Mentha viridis (spearmint) leaf oil, Citrus aurantifolia (lime) oil, Melaleuca alternifolia (tea tree) leaf oil, Citrus grandis (grapefruit) peel oil, Citrus medica limonum (lemon) peel oil, rose flower oil, Eucalyptus globulus leaf oil, and their combinations.

[0070] The expression "silicone oil" designates an oil comprising at least one silicon atom and, in particular, at least one Si-O group. The expression "fluorinated oil" designates an oil comprising at least one fluorine atom. The expression "oil "hydrocarbon-based" means an oil consisting primarily of hydrogen and carbon atoms. The hydrocarbon-based oil may be a hydrocarbon-based animal oil, a hydrocarbon-based vegetable oil, a hydrocarbon-based mineral oil, or a hydrocarbon-based synthetic oil. In addition, a suitable oil may be a hydrocarbon-based mineral oil, a hydrocarbon-based vegetable oil, or a hydrocarbon-based synthetic oil. Silicone oils

[0071] The composition may comprise one or more silicone oils. Non-limiting examples of silicone oils include dimethicone, cyclomethicone, polysilicone-11, phenyltrimethicone, trimethylsilylamodimethicone, and steaoxytrimethylsilane. In some cases, the cosmetic composition includes dimethicone and, optionally, additional oils, including additional silicone oils. Typically, the one or more silicone oils are a non-volatile silicone oil.In some embodiments, the silicone oil is polydimethylsiloxanes (PDMS), polydimethylsiloxanes comprising alkyl or alkoxy groups that are pendant and / or at the end of the silicone chain, which groups each contain from 2 to 24 carbon atoms, or phenylated silicones, such as phenyl trimethicones, phenyl dimethicones, phenyl(trimethylsiloxy)diphenylsiloxanes, diphenyldimethicones, diphenyl(methyldiphenyl)trisiloxanes or (2-phenylethyl)trimethylsiloxysilicates.

[0072] Other examples of silicone oils which may be mentioned include linear or cyclic volatile silicone oils, in particular those having a viscosity of 8 centistokes (8 x 106 m2 / s) and containing in particular from 2 to 7 silicon atoms, these silicones optionally comprising alkyl or alkoxy groups containing from 1 to 10 carbon atoms. As volatile silicone oils which may be used in the invention, mention may be made in particular of octamethylcyclotetrasiloxane, decamethylcyclopentasi loxane, dodecamethylcyclohexasiloxane, heptamethylhexyltrisiloxane, heptamethyloctyltrisiloxane, hexamethyldisiloxane, octamethyltrisiloxane, decamethyltetrasiloxane and dodecamethylpentasiloxane, and mixtures thereof. Fluorinated oils

[0073] The cosmetic composition may comprise one or more fluorinated oils. For example, the one or more fluorinated oils may be selected from the group consisting of perfluoromethylcyclopentane, perfluoro-1,3-dimethylcyclohexane, dodecafluoropentane, tetradecafluorohexane, bromoperfluorooctyl, nonafluoromethoxybutane, nonafluoroethoxyisobutane and 4-trifluoromethylpe rfluoromorpholine. Volatile fluorinated oils, such as nonafluoromethoxybuta ne, decafluoropentane, tetradecafluorohexane and dodecafluoropentane, can also be used. Hydrocarbon-based oils

[0074] The composition may comprise one or more hydrocarbon-based oils. For example, the hydrocarbon-based oil may be a saturated hydrocarbon, an unsaturated hydrocarbon, lipids, triglycerides, a natural oil, and / or a synthetic oil. In some embodiments, the cosmetic composition may include a synthetic oil selected from the group consisting of a hydrogenated polyisobutene and a hydrogenated polydecene. A hydrocarbon-based oil may be a non-volatile hydrocarbon-based oil, such as: i. hydrocarbon-based oils of vegetable origin, such as glyceride triesters, which are generally triesters of fatty acids and glycerol, the fatty acids of which may have varying chain lengths of C4 to C24, these chains being able to be saturated or unsaturated and linear or branched;These oils are in particular wheat germ oil, sunflower oil, grape seed oil, sesame oil, corn oil, apricot oil, castor oil, shea oil, avocado oil, olive oil, soybean oil, sweet almond oil, palm oil, rapeseed oil, cottonseed oil, hazelnut oil, macadamia oil, jojoba oil, alfalfa oil, poppy seed oil, pumpkin seed oil, pumpkin seed oil, blackcurrant oil, evening primrose oil, millet oil, barley oil, quinoa oil, rye oil, safflower oil, bancoul nut oil, passionflower oil and rosehip oil. ; ii. synthetic ethers containing from 10 to 40 carbon atoms; iii. linear or branched hydrocarbons of mineral or synthetic origin, such as petroleum jelly, polydecenes, hydrogenated polyisobutene such as Parleam and squalane 40; iv. synthetic esters, for example oils of formula RCOOR' in which R represents a linear or branched fatty acid residue containing from 1 to 40 carbon atoms and R' represents a hydrocarbon chain which is in particular branched, containing from 1 to 40 carbon atoms provided that R + R' is equal to 10, for example, Purcellin oil (cetearyl octanoate), isopropyl myristate, isopropyl palmitate, a C12-C15 alkyl benzoate, such as the product sold under the trade name Finsolv TN® or Witconol TN® by Witco or Tegosoft TN® by Evonik Goldschmidt, 2-ethylphenyl benzoate, such as the commercial product sold under the name X-Tend 226 by ISP, isopropyl lanolate, hexyl laurate, adipate diisopropyl, isononyl isononanoate, oleyl erucate, 2-ethylhexyl palmitate, isostearyl isostearate, diisopropyl sebacate, such as the product sold under the name "Dub Dis" by Stearinerie Dubois, octanoates, decanoates or ricinoleates of alcohols or polyols, such as propylene glycol dioctanoate; hydroxylated esters, such as isostearyl lactate or diisostearyl malate; and pentaerythritol esters; citrates or tartrates, such as di(C12-C13 linear alkyl) tartrates, such as those sold under the name Cosmacol ETI® by Enichem Augusta Industriale, as well as di(C14-C15 linear alkyl) tartrates, such as those sold under the name Cosmacol ETL® by the same company; or acetates; v. fatty alcohols which are liquid at room temperature, containing a branched and / or unsaturated carbon-based chain containing from 12 to 26 carbon atoms, for example octyldodecanol, isostearyl alcohol, oleyl alcohol, 2-hexyldecanol, 2-butyloctanol and 2-undecylpentadecanol; vi. higher fatty acids, such as oleic acid, linoleic acid, or linolenic acid; vii. carbonates, such as dicaprylyl carbonate, such as the product sold under the name Cetiol CC© by Cognis; viii. fatty amides, such as isopropyl N-lauroyl sarcosinate, such as the product sold under the trade name Eldew SL 205© from Ajinomoto; and ix. essential oils selected from the group consisting of sunflower oil, sesame oil, peppermint oil, macadamia nut oil, tea tree oil, evening primrose oil, sage oil, rosemary oil, coriander oil, thyme oil, pimento berry oil, rose oil, anise oil, balsam fir oil, bergamot oil, rosewood oil, cedarwood oil, chamomile oil, sage oil, clary sage oil, clove oil, cypress oil, eucalyptus oil, fennel oil, sea fennel oil, frankincense oil, geranium oil, ginger oil, grapefruit oil, jasmine oil, juniper berry oil, lavender oil, lemon oil, lemon verbena oil, lime oil, mandarin oil, marjoram oil, myrrh, neroli oil, orange oil,patchouli oil, pepper oil, black pepper oil, petitgrain oil, pine oil, rose otto oil, rosemary oil, sandalwood oil, spearmint oil, nard oil, vetiver oil, wintergreen oil, and ylang ylang.

[0075] The hydrocarbon-based oils may be glyceride triesters and in particular caprylic / capric acid triglycerides, synthetic esters and in particular isononyl isononanoate, oleyl erucate, C12-C15 alkyl benzoate, 2-ethylphenyl benzoate and fatty alcohols, such as octyldodecanol. As volatile hydrocarbon oils, mention may be made of hydrocarbon oils containing from 8 to 16 carbon atoms and in particular branched C8-C16 alkanes, such as C8-C16 isoalkanes of petroleum origin (also known as isoparaffins), such as isododecane (also known as 2,2,4,4,6-pentamethylheptane), isodecane or isohexadecane, oils sold under the trade names Isopar or Permethyl, branched C8-C16 esters, and isohexyl neopentanoate.

[0076] In some embodiments, the cosmetic composition may comprise one or more oils such as those described herein above, and oils that may be selected from a branched or linear liquid alkane with a carbon chain length of C1 1 to C20. In various embodiments, the liquid alkanes may be selected from those having a carbon chain length of C1 1 to C20. The liquid alkanes may be selected from those having a carbon chain length of C11 to C20, or C15 to C19, or one of C11, C12, C13, C14, C15, C16, C17, C18 to C19. In some embodiments, suitable liquid alkanes that may be used according to the disclosure include hydrocarbon-based oils containing from 8 to 16 carbon atoms, and particularly branched C8-C16 alkanes such as C8-C16 isoalkanes.

[0077] In some embodiments, the cosmetic composition may comprise one or more oils selected from polar emollients selected from esters, triglycerides, ethers, carbonates, alcohols, oils, butters, fatty acids, and combinations thereof. In various embodiments, the polar emollients may be selected from those having a molecular weight of 400 g / mol or less. More generally, the polar emollient may have a molecular weight in the range of about 50 g / mol% to about 350 g / mol.

[0078] In some embodiments, the cosmetic composition may comprise polar emollients which include those derived from C12-C50 fatty acids, preferably C16-C22 saturated fatty acids and monohydric alcohols. In some embodiments, these esters may be selected from isopropyl myristate, methyl palmitate, isopropyl laurate, isopropyl palmitate, ethylhexyl palmitate, ethylhexyl laurate, ethylhexyl oleate, ethylhexyl isononanoate, myristyl myristate, 2-ethylhexyl caprate / caprylate (or octyl caprate / caprylate), 2-ethylhexyl palmitate, isostearyl neopentanoate, isononyl isononanoate, hexyl laurate, acid esters lactic and fatty alcohols containing 12 or 13 carbon atoms, dicaprylyl carbonate and mixtures thereof.

[0079] The one or more oils, if any, may be present in the cosmetic composition in an amount of from about 0.0001% to about 20% or from about 0.001% to about 0.0010%, or from about 0.003% to about 0.004%, or from about 0.01% to about 0.1%, or from about 0.1% to about 10%, or from about 0.5% to about 20%, or from about 1% to about 10%, or from about 5% to about 10%, or from about 2% to about 7%, or from about 0.5% to about 2%, or from about 0.008% to about 0.01%, or from about 0.1% to about 0.2%, or from about 0.5% to about 2%, or about any combination, appropriate subcombination, range or subrange of these values ​​by weight, relative to the weight of the cosmetic composition. However, those skilled in the art will understand that other ranges fall within the scope of the invention.In some embodiments, the cosmetic composition includes more than one oil, each oil being present in an amount as set forth above, wherein each different oil (such as, for example, vegetable oils and extracts with oils) may be present in one of the ranges selected from the ranges set forth above.

[0080] Thus, each oil or combination of oils, if any, may be present by weight, relative to the total weight of the cosmetic composition, in an amount of about 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2, 3, 4, 5, 6, 7, 8, 9 to about 10 percent, including intermediate increments and ranges. Additional cosmetic active ingredients

[0081] In some embodiments, the cosmetic composition may include one or more additional cosmetic actives in addition to vitamin C, dandelion root extract, and one or more of caffeine, vitamin E, and lavender oil as described herein. In some embodiments, more than one additional cosmetic active may be present in the cosmetic composition, the active being selected to provide one or more benefits, such as, but not limited to, lightening / whitening, improvement of skin tone, control or reduction of blemishes, reduction of redness, anti-aging, and hydration. Some cosmetic activities may be antimicrobial or preservative in nature, or may include pH adjusters or chelating agents.

[0082] In some embodiments, the cosmetic composition includes at least one cosmetic active selected from the group consisting of adenosine, citric acid, hydroxypropyltetrahydropyrantriol, methyl dihydrojasmonate, phenoxyethanol, potassium hydroxide, salicylic acid, sodium citrate, tetrasodium glutamate diacetate, peptides, and combinations thereof.

[0083] In certain particular embodiments, the cosmetic composition includes adenosine, citric acid, hydroxypropyltetrahydropyrantriol, methyl dihydrojasmonate, phenoxyethanol, potassium hydroxide, salicylic acid, sodium citrate and tetrasodium glutamate diacetate.

[0084] In some embodiments, the actives may be selected from anti-aging ingredients including hydroxypropyltetrahydropyrantriol, one or more humectants, such as methyl gluceth-20, and one or more vitamins or vitamin derivatives, or one of sodium citrate, citric acid, dipotassium glycyrrhizate, Anogeissus Leiocarpus bark extract, hydrolyzed Rhodophycea extract, hydrolyzed flax seed extract, Pseudoalteromonas ferment extract, Manilkara Multinervis leaf extract, Lavandula Hybrida oil, Grifola Frondosa fruiting body extract, Plantago Lanceolata leaf extract, Cyathea Medullaris leaf extract, hydrolyzed hyaluronic acid, Malus fruit cell culture extract Domestica, resveratrol, Salicyloyl Phytosphingosine, glaucine, retinol, retinoic acid, and combinations thereof.

[0085] In some embodiments, the actives may be selected from oily skin treatment ingredients including lens esculenta (lentil) seed extract, sarcosine, Peumus Boldus leaf extract, Crithmum Maritimum extract, niacinamide, salicylic acid, hydroxyethylpiperazineethane sulfonic acid, Spiraea Ulmaria extract, pentaerythrityl tetra-di-t-butylhydroxyhydrocinnamate, and combinations thereof.

[0086] In some embodiments, the actives may be selected from complexion-enhancing ingredients, including Ophiopogon Japonicus root extract, Chenopodium quinoa seed extract, Tamarindus indica seed gum, xylitylglucoside (and) anhydroxylitol (and) xylitol, ceramide derivatives, Helianthus annuus (sunflower) seed oil unsaponifiables, myristyl malate phosphonic acid, mannose, 2-oleamido-1,3-octadecanediol, and combinations thereof.

[0087] In some embodiments, the actives may be selected from anti-redness active ingredients including madecassoside, saccharide isomerate, palmitoyl tripeptide-8, panthenol, olea europaea (olive) leaf extract, Mentha piperita (peppermint) extract, Leontopodium alpinum extract, dipotassium glycyrrhizate, acetyl dipeptide-1 cetyl ester, acetyl tetrapeptide-15, Boswellia serrata extract, sodium palmitoyl proline (and) nymphaea alba flower extract, and combinations thereof.

[0088] In some embodiments, the actives may be selected from glycerin and glycols such as, for example, propylene glycol, butylene glycol, dipropylene glycol and diethylene glycol, glycol ethers such as (C1-C4) alkyl ethers of monopropylene, dipropylene and tripropylene glycol, monoethylene, diethylene and triethylene glycol; salicylic acid and combinations thereof.

[0089] In some embodiments, the active ingredients may be selected from algae and plankton extracts, enzymes and coenzymes, ceramides, antioxidant compounds, including phenolic compounds, such as chalcones, flavones, flavanones, flavanols, flavonols, dihydroflavonols, isoflavonoids, neoflavonoids, catechins, anthocyanidins, tannins, lignans, aurones, stilbenoids, curcuminoids, alkylphenols, betacyanins, capsacinoids, hydroxybenzoketones, methoxyphenols, naphthoquinones, and phenolic terpenes, curcumin, pinoresinol, hydroxytyrosol, cinnamic acid, caffeic acid, p-coumaric acid, baicalin, and other extracts and their combinations.

[0090] In some embodiments, the actives may be selected from anti-elastase and anti-collagenase agents, peptides, fatty acid derivatives, steroids; free radical scavengers, vitamins, and vitamin derivatives, phenylethylresorcinol, alpha- and beta-hydroxy acids, and hydrogen peroxide.

[0091] In some embodiments, the actives may be selected from sunscreen agents (e.g., an inorganic sunscreen agent, such as titanium dioxide and zinc oxide and organic sunscreen agents, such as octocrylene, ethylhexyl salicylate, homosalate and avobenzone); and combinations thereof.

[0092] In some embodiments, one or more optional additional cosmetic actives are water soluble.

[0093] Although the optional active additives are given as examples, it will be understood that other optional components compatible with cosmetic applications known in the art may be used.

[0094] In various embodiments, one or more additional cosmetic actives, alone or in combination, if desired, may be present in the cosmetic composition in an amount of from about 0.00001% to about 25%, or from about 0.00005% to about 15%, or from about 0.0001% to about 2%, or from about 0.05% to about 1%, or from about 0.02% to about 2%, or from about 0.2% to about 1%, or any suitable combination, subcombination, range or subrange of these values ​​by weight, based on the weight of the cosmetic composition. However, those skilled in the art will understand that other ranges are within the scope of the invention. In some embodiments, the composition cosmetic composition comprises two, three, four or more actives, some or all of which may be water-soluble. In some embodiments, the cosmetic composition includes more than one additional cosmetic active, each additional cosmetic active being present in an amount as indicated above, wherein each different additional cosmetic active may be present in one of the ranges selected from the ranges set forth above.

[0095] Thus, each additional cosmetic active ingredient or combination of additional cosmetic active ingredients, where appropriate, may be present by weight, relative to the total weight of the cosmetic composition, in an amount of approximately 0.00001, 0.00002, 0.00003, 0.00004, 0.00005, 0.00006, 0.00007, 0.00008, 0.00009, 0.0001, 0.0002, 0.0003, 0.0004, 0.0005, 0.0006, 0.0007, 0.0008, 0.0009, 0.001, 0.0002, 0.0003, 0.0004, 0.0005, 0.0006, 0.0007, 0.0008, 0.0009, 0.001, 0.002, 0.003, 0.004, 0.005, 0.006, 0.007, 0.008, 0.009, 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, to about 25 percent, including intermediate increments and ranges. Optional additives

[0096] The cosmetic composition may also comprise one or more optional additives used in the cosmetic field which do not negatively affect the properties of the cosmetic composition according to the invention.

[0097] Optional additives may be selected from perfumes, pearlescent agents, fillers, powders, preservatives, proteins, protein hydrolysates, vitamins, silicones, odor absorbers, and coloring materials; skin conditioners, moisturizers, antimicrobial components, including, but not limited to, phenoxyethanol, chlorphenesin, capryloyl glycol, and sodium salicylate; thickeners and fillers, fruit extracts, e.g., Pyrus Malus (apple) fruit extract, and Aloe Barbadensis leaf juice powder; citric acid, sodium chloride; pH neutralizing or adjusting agents (e.g., triethylamine (TEA) and sodium hydroxide), and combinations thereof.

[0098] In some embodiments, the optional additives may be selected from fillers. The fillers may be of mineral or organic origin, natural or synthetic, to provide oil absorption or optical effects. The oil-absorbing fillers may provide a matte effect and a non-greasy feel to the skin. The optical effect fillers may provide a soft focus / veil / blurring effect to the skin, give the skin a more even appearance, reduce the appearance of skin imperfections or discolorations, or reduce the visibility of pores.

[0099] Optionally, a filler may include a vinyldimethicone / methicone silsesquioxane crosslinked polymer, ammonium polyacryloyldimethyltaurate, a methyl methacrylate crosslinked polymer, silica silylate, mica, Zea starch mays (corn), magnesium oxide, nylon-12, nylon-66, cellulose, polyethylene, talc, talc (and) methicone, talc (and) dimethicone, perlite, sodium silicate, pumice, PTFE, ammonium polyacryloyldimethyltaurate, polymethyl methacrylate, oryza sativa (rice) starch, aluminum starch octenylsuccinate, modified potato starch, alumina, calcium sodium borosilicate, magnesium carbonate, hydrated silica, dimethicone / vinyldimethicone crosspolymer, sodium carboxymethyl starch glycolate, bismuth oxychloride, silica silylate, boron nitride, iron oxide, calcium carbonate, calcium sulfate (and) iron oxides, sodium-potassium-aluminum silicate, silica, silica (and) methicone, silica (and) dimethicone, polysilicone-22, polysilicone-8, polysilicone-11,a methyl methacrylate crosslinked polymer, polymethylsilsesquioxane, a methylsilanol / silicate crosslinked polymer, a vinyldimethicone / methicone silsesquioxane crosslinked polymer, a diphenyldimethicone / vinyl diphenyldimethicone silsesquioxane crosslinked polymer, and a styrene / acrylates copolymer.

[0100] Although the optional active additives are given as examples, it will be understood that other optional components compatible with cosmetic applications known in the art may be used.

[0101] In various embodiments, if applicable, the amount of optional additives present in the cosmetic composition may range from about 0.001% to about 50%, or from about 0.01% to about 30%, or from about 1.5% to about 20%, and from about 5% to about 15%, or from about 0.005% to about 0.1%, or from about 0.05% to about 1%, or from about 0.06% to about 0.075%, or from about 0.1% to about 1%, or from about 0.25% to about 5%, and from about 0.5% to about 3.5%, or from about 0.2% to about 0.8%, or any suitable combination, subcombination, range or subrange of these values ​​by weight, based on the weight of the cosmetic composition. However, those skilled in the art will understand that other ranges fall within the scope of the invention.In some embodiments, the cosmetic composition includes more than one optional component, each optional component being present in an amount as set forth above, wherein each different optional component may be present in one of the ranges selected from the ranges set forth above.

[0102] Thus, each optional component or combination of optional components, if any, may be present by weight, relative to the total weight of the cosmetic composition, in an amount of approximately 0.001, 0.002, 0.003, 0.004, 0.005, 0.006, 0.007, 0.008, 0.009, 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 25, 30, 35, 40, 45 to approximately 50 percent, including intermediate increments and ranges. EXAMPLES

[0103] The following examples are provided for illustrative purposes only and are not intended to be limiting. Example 1#: Raw materials

[0104] The raw materials used in the exemplary compositions include, in part, those listed in Table 1. Table 1#: Raw materials (partial list) RAW MATERIAL % ACTIVE (IF LESS THAN 100%) 3-O-ETHYLASCORBIC ACID TARAXA CUM OFFICINALE (DANDELION) ROOT / RHIZOME EXTRACT 4.3 (the balance being water, pentylene glycol) CAFFEINE TOCOPHERYL / TOCOPHERYL ACETATE LAVANDULA ANGUSTIFOLIA (LAVENDER) OIL HYDROXYPROPYL TETRAHYDROPYRANTR IOL 35 (the balance being water, propylene glycol) TETRASODIUM GLUTAMATE DIACETATE 47.5 (the balance being water) Example 2#: Compositions

[0106] A representative example of a composition of the invention is presented in Table 2.

[0107] Table 2: Composition of the invention A (an amount in the table below reflects the final weight % of active in the composition for actives that are less than 100% in the MP) Composition of the invention A Ingredient Quantity 3-O-ETHYLASCORBIC ACID 1.00 ADENOSINE 0.04 ALCOHOL DENAT. 3.00 CAFFEINE 0.10 CITRIC ACID 0.12 CYMBOPOGON MARTINI OIL 0.02 GLYCERIN 5.00 HYDROXYETHYLCELLULOSE 0.40 HYDROXYPROPYL TETRAHYDROPYRANTRIOL 1.75 LAVANDULA ANGUSTIFOLIA (LAVENDER) OIL 0.015 METHYL DIHYDROJASMONATE 0.10 PEG / PPG / POLYBUTYLENE GLYCOL-8 / 5 / 3 GLYCERIN 2.00 PHENOXYETHANOL 0.50 POTASSIUM HYDROXIDE 0.18 PPG-6-DECYLTETRADECETH-30 0.80 PROPYLENE GLYCOL 7.25 PENTYLENE GLYCOL 0.30 ACID SALICYLIC ACID 0.45 SODIUM CITRATE 0.10 TARAXACUM OFF ICINALE (DANDELION) ROOT / RHIZOME EXTRACT 0.13 TETRASODIUM GLUTAMATE DIACETATE 0.095 TOCOPHEROL / TOCOPHERYL ACETATE 0.10 WATER QS (-76)

[0108] In some embodiments, the cosmetic composition may include the following ingredients in amounts by total weight of the cosmetic composition that include: 3-O-ethylascorbic acid (-1.00), adenosine (-0.04), alcohol denat. (-3.00), Caffeine (-0.10), Citric Acid (-0.12), Cymbopogon Martini Oil (-0.02), Glycerin (-5.00), Hydroxyethylcellulose (-0.40), Hydroxypropyltetrahydropyra ntriol (-1.75), Lavandula Angustifolia (Lavender) Oil (-0.015), Methyl Dihydrojasmonate (-0.10), PEG / PPG / Polybutylene Glycol-8 / 5 / 3 Glycerin (-2.00), Phenoxyethanol (-0.50), Potassium Hydroxide (-0.18), PPG-6-Decyltetradeceth-3 0 (-0.80), Propylene Glycol (-7.25), Pentylene Glycol (-0.30), Salicylic Acid (-0.45), Sodium Citrate (-0.10), Extract of Taraxacum Officinale (Dandelion) Rhizome / Root (-0.13), Tetrasodium Glutamate Diacetate (-0.095), Tocopherol / Acetate tocopheryl (-0.10), water (-76), all being present by weight relative to the weight of the cosmetic composition. Example 2#: In vitro glycation study.

[0109] A study was conducted in vitro / in tubo to evaluate whether the ingredients of the composition of the invention possess anti-glycation effects in an in tubo environment.

[0110] In tubo experiments were conducted to evaluate the glycation of BSA (bovine serum albumin) under conditions with controls and with exposure to an embodiment of the composition of the invention. Samples were prepared, including inventive, comparative, reference, and positive and negative controls.

[0111] A test plate was prepared with separate wells to accommodate each of the test compositions. Solutions representing the active ingredient concentrations listed under “Ingredient” in Table 3 below were added to a well containing BSA + D-ribose (the indicator solution) and PBS. The total amount of test solutions added for the compositions of the invention was always the same for all tests - 25 microliters - 5 microliters of each test solution (ingredient) per well. PBS was used as the solvent for the test solution. The plates were prepared in triplicate.

[0112] Test compositions: Blank: PBS + BSA, Negative control: PBS + BSA + D-ribose, Positive control: PBS + BSA + D-ribose + Aminoguanidine, five compositions of the invention

[0113] The concentrations listed in the table below represent the concentration of active in the test solution added to each well - each ingredient other than the indicator solutions was added in 5 ml amounts. For example, referring to composition Inv 4 of Table 3, five (5) microliters of each of activated C (3-O-ETHYLASCORBIC ACID), dandelion extract, caffeine, lavender oil and vitamin E (tocopherol), (5 microliters each -> 25 microliters total), each solution containing 50% of the active ingredient (activated C, dandelion extract, caffeine, lavender oil and vitamin E), in which each added ingredient had the initial concentration as indicated in the column corresponding to Inv 4, were added to wells containing the indicator solution.Inv 5 was tested in the same manner as Inv 4, except that each test solution contained 100% of the active ingredient (except caffeine, as shown in Table 3).

[0114] For compositions 1 to 5 of the invention: 5 x 5 microliters of each ingredient in the respective concentrations listed below were added to the [PBS + BSA + D-ribose] solution for a total volume of 250 microliters. In the 50% test combination, 2.5 microliters of each ingredient, except caffeine, were added. Caffeine was diluted separately with 5 microliters of PBS to obtain a concentration of 1.5%. Then, the diluted caffeine was added to the remaining solution to obtain a total volume of 250 microliters. In the 100% test combination, 5 microliters of each ingredient, except caffeine, were added. The caffeine was diluted separately with 5 microliters of PBS to obtain a concentration of 2%. Then, the diluted caffeine was added to the remaining solution to obtain a total volume of 250 microliters.

[0115] The samples evaluated in the glycation study are shown in Table 3. The amounts of ingredients listed in the compositions of the invention below represent amounts of test solution as described above, and not the final concentration of active ingredient.

[0116] Table 3: Samples for glycation study Ingredient Test Composition Ingredient Reference Negative Control Positive Control Inv 1 Inv 2 Inv 3 Inv 4 Inv 5 PBS + + + + + + + + BSA + + + + + + + D-Ribose + + + + + + + Aminoguanidine + Activated C (3-O-ETHYLASCORBIC ACID 1 5 10 50 100 Dandelion Extract 3 15 30 50 100 CAFFEINE 0.1 0.5 1 1.5 2 Lavender Oil 0.01 5 0.08 0.15 50 100 Vitamin E (Tocopheryl Acetate) 0.1 0.5 1 50 100 Protocol#:

[0117] Samples were plated in triplicate and measurements were taken at the indicated wavelength on days 1 and 14.

[0118] Fluorescence intensity assessments were performed at ex 370 nm / em 440 nm

[0119] The samples were evaluated at intervals of 0 days, 3 days, 14 days and 21 days. The main objective of incorporating time intervals is to have a sufficient duration to capture the anti-glycation effect. It is essential to incorporate multiple time points to properly capture anti-glycation effects, as they can vary depending on the specific ingredients used.

[0120] The magnitude of fluorescence intensity is a positive indication of the extent of glycation. Glycation should be maximal with the negative control (BSA plus D-ribose), while glycation of the positive control with a known anti-glycation agent, aminoguanidine, should be reduced compared to the negative control.

[0121] The summary data of the glycation study are presented in Table 4, in which the results presented are those of the measurements on day 14. Table 4#: Summary data Test Composition Fluorescence Intensity Percent Glycation Reduction (%) Reference - - Negative Control 3.805 0 Positive Control 2.921 23 Inv 1 3.134 17 Inv 2 2.883 24 Inv 3 2.939 23 Inv 4 (50% of all actives*) 2.964 22 Inv 5 (100% of all actives*) 2.664 30

[0123] * all active ingredients include activated vitamin C (3-O-ethylascorbic acid), Dandelion extract, caffeine, vitamin E (tocopherol), lavender extract Results#:

[0124] A significant anti-glycation effect was observed with the composition of the invention at all levels of components tested.

[0125] Evaluation of the anti-glycation effect of individual ingredients: Each of activated C, dandelion extract, caffeine, lavender oil and vitamin E (5 microliter amounts) was introduced into a plate with 245 microliters of [PBS + BSA + D-ribose]. The concentrations of each ingredient added to the wells were as follows: activated C (100%, 50%, 10%, 5% and 1%), dandelion extract (100%, 50%, 30%, 15% and 3%), caffeine (2%, 1.5%, 1%, 0.5% and 0.1%), lavender oil (100%, 50%, 0.15%, 0.08% and 0.15%) and vitamin E (100%, 50%, 1%, 0.5% and 0.1%). Results with the individual ingredients (not shown) demonstrated that each of activated C and dandelion extract only exhibited a glycation effect at high levels, and no glycation effects were observed with caffeine, lavender oil, or vitamin E.

[0126] The key ingredients having concentrations in the final formula showed significant benefits in reducing glycation compared to the condition treated with D-ribose alone, demonstrating synergistic effects in combination when no significant effects were shown when each ingredient was tested individually at the lower levels or at the level in the final formula.

[0127] Embodiments of the composition of the invention showed significant benefits in reducing glycation compared to the negative control (condition treated with D-ribose alone without an anti-glycation agent), and compared to the individual ingredients of the composition of the invention tested alone. Ascorbic acid and dandelion extract, respectively, when tested alone demonstrated a reduction in glycation only at high doses, while each of caffeine, lavender oil and vitamin E demonstrated no significant reduction in glycation.

[0128] The data reveal that embodiments of the composition of the invention exhibit statistically less glycation than with the actives alone, demonstrating synergistic effects in combination, and that the overall results with the compositions of the invention are comparable to those of the known anti-glycation ingredient, aminoguanidine.

[0129] The articles "a" and "an" as used herein, mean one or more when applied to any feature in embodiments of the present invention described in the specification and claims. The article "the", "the", "the" preceding singular or plural nouns or noun phrases denotes a specified particular feature or specified particular features and may have a singular or plural connotation depending on the context in which it is used. The adjective "any", "all" means one, some or all indiscriminately, regardless of quantity.

[0130] “One or more,” as used herein, means one or more and thus includes individual components as well as mixtures / combinations.

[0131] The transitional terms "comprising", "consisting essentially of" and "consisting of", when used in the appended claims, in their original and amended form, define the scope of the claims with respect to additional unmentioned elements or steps, if any, which are excluded from the scope of the claim(s). The term "comprising" is intended to be inclusive or broad and does not exclude any additional, unmentioned element, process, step or material. The term "consisting of" excludes any element, step or material other than those specified in the claims and, in the latter case, impurities ordinarily associated with the specified material(s). The phrase "consisting essentially of" limits the scope of a claim to the specified elements, steps, or material(s) and to those which do not materially affect the fundamental and novel feature(s) of the claimed invention. All methods and materials described herein which incorporate the present invention may, in alternative embodiments, be more specifically defined by any of the transitional phrases "comprising," "consisting essentially of," and "consisting of."

[0132] The terms "free" and "devoid" indicate that no reliably measurable excluded material is present in the cosmetic composition, typically 0% by weight, based on the total weight of the cosmetic composition. The term "substantially free" means that, although it is preferable that no excluded material be present in the cosmetic composition, it is possible to have very small amounts of the excluded material in the cosmetic composition of the invention, provided that such amounts do not materially affect the beneficial properties of the cosmetic composition. In particular, "substantially free" means that the excluded material may be present in the cosmetic composition in an amount of less than about 0.1% by weight, based on the total weight of the cosmetic composition.

[0133] In addition to working examples, or unless otherwise indicated, it is understood that all numbers expressing amounts of ingredients and / or reaction conditions are modified in all cases by the term "about," meaning plus or minus 10% of the number indicated (e.g., "about 10%" means 9% to 11% and "about 2%" means 1.8% to 2.2%).

[0134] All percentages and ratios are, unless otherwise indicated, calculated by weight. All percentages are, unless otherwise indicated, calculated based on the total composition. In general, unless otherwise expressly indicated herein, "weight" or "amount" as used herein with respect to the percentage amount of an ingredient refers to the amount of raw material comprising the ingredient, wherein the raw material may be described herein as comprising less than and up to 100% activity of the ingredient. Accordingly, the weight percentage of an active ingredient in a composition is represented as the amount of raw material containing the active ingredient that is used and may or may not reflect the final percentage of the active ingredient, wherein the final percentage of the active ingredient depends on the weight percentage of the active ingredient in the raw material.

[0135] All ranges and quantities given herein are intended to include sub-ranges and quantities using any disclosed point as a bound. Thus, a range of “1% to 10%, such as 2% to 8%, such as 3% to 5%,” is intended to encompass the ranges from "1% to 8%", from "1% to 5%", from "2% to 10%", and so on. All figures, quantities, ranges, etc. are intended to be modified by the term "about", whether or not expressly stated. Similarly, a given range of "about 1% to 10%" is intended to have both its 1% and 10% limits modified by the term "about". Furthermore, it is understood that where a quantity of a component is given, it is intended to mean the quantity of the active ingredient unless specifically stated otherwise.

[0136] Although the numerical ranges and parameters within the general scope of the disclosure are approximations, unless otherwise indicated, the numerical values ​​presented in the specific examples are reported as accurately as possible. However, any numerical value inherently contains certain errors necessarily resulting from the standard deviation observed in their respective test measurements. The following example serves to illustrate embodiments of the present disclosure without, however, being limiting in nature.

[0137] Although the invention has been described with reference to one or more embodiments, those skilled in the art will understand that various changes may be made and equivalents may be substituted for elements thereof without departing from the scope of the invention. In addition, numerous modifications may be made to adapt a particular situation or subject matter to the teachings of the invention without departing from the essential scope thereof. Accordingly, the invention is not limited to the particular embodiment disclosed as the best mode contemplated for carrying out this invention, but the invention will include all embodiments falling within the scope of the appended claims. Furthermore, all numerical values ​​identified in the detailed description are to be interpreted as if both the precise and approximate values ​​were expressly identified.

Claims

Claims

1. A cosmetic composition comprising: a. a mixture of skin actives comprising vitamin C, a vitamin C derivative, or a combination thereof; a dandelion root extract; and at least one additional active selected from the group consisting of caffeine, vitamin E, lavender oil, and combinations thereof; and b. an aqueous carrier system comprising water, wherein the cosmetic composition inhibits the glycation of peptides and proteins.

2. The cosmetic composition of claim 1, wherein the cosmetic composition includes at least one additive selected from the group consisting of solvents, surfactants, thickeners, oils, waxes, preservatives, brighteners, effect pigments, essential oils, plant extracts, cosmetic actives, and combinations thereof.

3. A cosmetic composition according to claim 1 or 2, wherein the vitamin C, vitamin C derivative or combination thereof is present in an amount of from about 0.2% to about 50%, the dandelion root extract is present in an amount of from about 0.05% to about 5%, and each of the at least one additional active is present in an amount of from about 0.01% to about 5%, all percentages being by weight, based on the total weight of the cosmetic composition.

4. A cosmetic composition according to any preceding claim, wherein the vitamin C, vitamin C derivative, or combination thereof is selected from the group consisting of 1-ascorbic acid, acetyl-C (3-O-ethylascorbic acid), magnesium ascorbyl phosphate, sodium ascorbyl phosphate, tetrahexyldecyl ascorbate, ascorbyl glucoside, and combinations thereof.

5. A cosmetic composition according to any preceding claim, wherein the vitamin C, vitamin C derivative or a combination thereof comprises acetyl-C.

6. A cosmetic composition according to claim 5, wherein the at least one additional active ingredient comprises caffeine, vitamin E and lavender oil.

7. Cosmetic composition according to claim 6, in which: a. acetyl-C is present in an amount of about 0.2% to about 10% by weight, based on the total weight of the cosmetic composition; b. dandelion root extract is present in an amount of about 0.08% to about 1.5% by weight, based on the total weight of the cosmetic composition; c. caffeine is present in an amount of about 0.05% to about 1% by weight, based on the total weight of the cosmetic composition; d. vitamin E is present in an amount of about 0.05% to about 1% by weight, based on the total weight of the cosmetic composition; e. lavender oil is present in an amount of about 0.01% to about 1% by weight, based on the total weight of the cosmetic composition.

8. A cosmetic composition according to any one of claims 2 to 7, wherein the cosmetic composition comprises: a. at least one water-soluble solvent selected from the group consisting of denatured alcohol, glycerin, propylene glycol, pentylene glycol, PEG / PPG / polybutylene glycol-8 / 5 / 3 glycerin, propanediol, butylene glycol, and combinations thereof; b. at least one thickener selected from the group consisting of hydroxyethylcellulose, xanthan gum, hydroxypropylcellulose, sclerotium gum, guar gum, acacia gum, gellan gum, hydroxypropylguar, and combinations thereof; c. at least one surfactant selected from the group consisting of PPG-6-decyltetradeceth-30, PEG-60 hydrogenated castor oil, laureth-23, polyglyceryl-2-oleate, polyglyceryl-4-caprate and combinations thereof; d.at least one cosmetic active ingredient selected from the group consisting of adenosine, citric acid, hydroxypropyltetrahydropyrantriol, methyl dihydrojasmonate, phenoxyethanol, potassium hydroxide, salicylic acid, sodium citrate, tetrasodium glutamate diacetate, peptides, niacinamide, camosine, and combinations thereof.

9. Cosmetic composition according to claim 8, wherein the at least one water-soluble solvent comprises alcohol, glycerin, propylene glycol, pentylene glycol and PEG / PPG / polybutylene glycol-8 / 5 / 3 glycerin; the at least one thickener comprises hydroxyethylcellulose; the at least one surfactant comprises PPG-6-decyltetradeceth-30; At least one additional active comprises adenosine, citric acid, hydroxypropyltetrahydropyrantriol, methyl dihydrojasmonate, phenoxyethanol, potassium hydroxide, salicylic acid, sodium citrate, and tetrasodium glutamate diacetate.

10. A cosmetic composition according to any preceding claim, wherein the cosmetic composition is a single-phase, two-phase or emulsion, and wherein the cosmetic composition is a leave-in treatment in the form of a cream, gel, lotion, tonic or serum.