A nano-emulsion composition for skin care application

Abstract

A nano-emulsion composition for skin care comprising: an oil, preferably selected from hydrocarbons, fatty esters, fatty carbonates, triglycerides, C15-C19 alkanes, umdecanes and tridecane, capric tri

Description

02 04 25 FIELD OF INVENTION

[0001] Embodiments of a present invention relates to emulsion composition, more particularly it relates to a nano-emulsion composition for skin care application. BACKGROUND

[0002] Emulsions are formulated to act as a moisture lock that seals in all the hydration and benefits of your essence and serums. The emulsions offer a lighter delivery method to moisturize skin and often are non-comedogenic. The emulsions also offer many of the same benefits of a cream, just in a lighter formula.

[0003] There are two basic types of emulsions: oil-in-water (O / W) and water-in-oil (W / O). In every emulsion there is a continuous phase that, suspends the droplets of the other element which is called the dispersed phase.

[0004] Oil-in-v / ater emulsions are conventionally defined as a thermodynamically unstable systems which include two immiscible liquids (generally water and oil), in which oil is distributed into the water. The oil-in-water Emulsions are used in moisturizing products and food products such as milk, vinaigrette and mayonnaise, o / w emulsions contain a low oil concentration. They are mixable with water, non-occlusive, non-greasy and will absorb water. The dispersion medium in these emulsions is water; o / w emulsifiers keep oil drops packed in water.

[0005] However, emulsion have several disadvantages such as thermodynamically unstable, short shelflife, improper formulation of emulsions 02 04 25 and improper selection of emulsifying agent. These parameters lead to phase inversion, creaming and cracking of the emulsion.

[0006] Hence, there is need for an emulsion composition with stable oil droplets over a wider temperature range. SUMMARY

[0007] In accordance with an embodiment of the invention, a nano-emulsion composition for skin care application is provided. The nano-emulsion composition being oil-in-water composition. The nano-emulsion composition includes at least one oil present in a percentage of >4 % by weight. The nano-emulsion composition includes at least one hydrophilic compound to create an aqueous phase. The at least one hydrophilic compound present in a percentage of 0.1 % to 15 % by weight. The nano-emulsion composition also includes at least one water soluble phytoactive compound present in a percentage of 0.5 % and 5 % by weight. The nano-emulsion composition includes at least one oil soluble phytoactive compound present in a percentage of 0.01 % and 5 % by weight. The nano-emulsion composition also includes a combination of polyglycerol fatty acid esters as emulsifiers. The combination of polyglycerol fatty acid esters comprise a first polyglycerol fatty acid ester and a second polyglycerol fatty acid ester in a ratio of 50:50. The first polyglycerol fatty acid ester having number of carbon atoms and mean polymerisation degree represented by C12G10, and the second polyglycerol fatty acid ester having number of carbon atoms and mean polymerisation degree represented by CisuGio. The combination of polyglycerol fatty acid esters present in a percentage of 1 % and 10 % by weight. Further the nano-emulsion composition includes at least one preservative present in a percentage of 0.5 % to 4 % by weight. The at least one oil is configured as a dispersed phase in the oil-in-water nano-emulsion composition, and comprises oil droplets of size 100 -300 nm. The nano-emulsion composition being oil in water emulsion composition with a transparency >75% for visible light. The oil droplets comprise phytoactive solubilised in the oil droplets mono-dispersed in the nano 02 04 25 emulsion composition. The nano-emulsion composition being a low viscous fluidic vehicle to be used as Serum, Micellar Water, Facial Cleanser etc. The nano-emulsion composition being capable of retaining high storage stability over a wider temperature range.

[0008] In accordance with another embodiment of the invention, a skin care composition comprising the nano-emulsion composition is provided.

[0009] In accordance with yet another embodiment of the invention, a cosmetic comprising the nano-emulsion composition is provided.

[0010] To further clarify the advantages and features of the present disclosure, a more particular description of the disclosure will follow by reference to specific embodiments thereof, which are illustrated in the appended figures. It is to be appreciated that these figures depict only typical embodiments of the disclosure and are therefore not to be considered limiting in scope. The disclosure will be described and explained with additional specificity and detail with the appended figures. DETAILED DESCRIPTION

[0011] For the purpose of promoting an understanding of the principles of the disclosure, reference will now be made to the embodiment illustrated in the figures and specific language will be used to describe them. It will nevertheless be understood that no limitation of the scope of the disclosure is thereby intended. Such alterations and further modifications in the illustrated biosynthesis of magnesium oxide nanostructures, and such further applications of the principles of the disclosure as would normally occur to those skilled in the art are to be construed as being within the scope of the present disclosure.

[0012] The terms "comprises", "comprising", or any other variations thereof, are intended to cover a non-exclusive inclusion, such that a process or method that 02 04 25 comprises a list of steps does not include only those steps but may include other steps not expressly listed or inherent to such a process or method. Similarly, one or more components, compounds, and ingredients preceded by "comprises... a" does not, without more constraints, preclude the existence of other components or compounds or ingredients or additional components. Appearances of the phrase "in an embodiment", "in another embodiment" and similar language throughout this specification may, but not necessarily do, all refer to the same embodiment.

[0013] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by those skilled in the art to which this disclosure belongs. The system, methods, and examples provided herein are only illustrative and not intended to be limiting.

[0014] In the following specification and the claims, reference will be made to a number of terms, which shall be defined to have the following meanings. The singular forms “a”, “an”, and “the” include plural references unless the context clearly dictates otherwise.

[0015] Embodiments of the present invention relates to a nano-emulsion composition for skin care application.

[0016] As used herein the term ‘nano-emulsion composition’ relates to a colloidal system consisting of mainly oil, surfactant and water with high kinetic stability, low viscosity and is optically transparent.

[0017] The nano-emulsion composition mainly comprises oil-in-water emulsion composition for skin care application. The nano-emulsion composition being oil in water emulsion composition with a transparency >75 % for visible light. An oil droplets present in the nano-emulsion composition are of nano sized with many phytoactives solubilised in them for skin care benefits. The oil droplets are mono-dispersed in the nano-emulsion composition, thereby causing a good active transport into targeted site such as epidermis-dermis junction in the skin. The invention provides a stable, homogeneous, aqueous fluid product 02 04 25 incorporating water-insoluble phytoactives into the nano-emulsion composition. The invention also provides an emollient which exhibits silky feel to the skin by virtue of proprietary oil incorporation into the nano-emulsion composition. The nano-emulsion composition being a low viscous fluidic vehicle to be used as Serum, Micellar Water, Facial Cleanser etc. The nano-emulsion composition being capable of retaining high storage stability over a wider temperature range.

[0018] In an embodiment, the nano-emulsion composition includes at least one oil. The at least one oil is present in a percentage of >4 % by weight, based on total weight of the nano-emulsion composition. When the at least one oil present in this range, provides emollience during application of the skin care product using the nano-emulsion composition. The at least one oil also contributes to solubilising the phytoactive in the nano-emulsion composition.

[0019] The at least one oil for use in the invention is a kind of oil agent usually used for skin product preparations such as cosmetics. In an embodiment, the such at least one oil include hydrocarbons, fatty esters, fatty carbonates and triglycerides. The at least one oil being used possess wide physicochemical characteristics.

[0020] In another embodiment, the at least one oil is selected from a group consisting C15-19 Alkane, Undecane and Tridecane, Capric Caprylic Triglyceride, Coco caprylate or Coco caprate, Dicaprylyl carbonate, Cetyl Ricinoleate, and Isoamyl Cocoate. Any one of the aforementioned oils or combinations thereof may be used in the nano-emulsion composition for skin care application. The detail of the said group is provided in Table 1. INCI Name Trade Name Supplier Origin C15-19 Alkane Emogreen (RTM) SEPPIC (RTM) France Undecane and Tridecane Cetiol (RTM) Ultimate BASF (RTM) Germany Capric Caprylic Triglyceride Radia(RTM)7104 Evonik (RTM) I IV UK Cococaprylate Cetiol (RTM) C5 BASF (RTM) Germany Dicaprylyl Carbonate Cetiol (RTM) CC BASF (RTM) Germany Cetyl Ricinoleate Tegosoft (RTM) CR Evonik (RTM) UK Isoamyl Cocoate Tegosoft (RTM) AC Evonik (RTM) UK Table 1 02 04 25

[0021] The at least one oil being configured to function as a dispersed phase in the oil-in-water nano-emulsion composition. The at least one oil comprises the oil droplets of size 100 -300 nm. The oil droplets present in the nano-emulsion composition include many phytoactives solubilised in them for skin care benefits. The oil droplets are mono-dispersed in the nano-emulsion composition, thereby causing a good active transport into targeted site such as epidermis-dermis junction in the skin.

[0022] In an embodiment, the nano-emulsion composition includes at least one hydrophilic compound to create an aqueous phase. The at least one hydrophilic compound is present in a percentage of between 0.1 % and 15 %, preferably 10% by weight, based on total weight of the nano-emulsion composition. The at least one hydrophilic compound configured to function as a continuous phase in the oil-in-water nano-emulsion composition.

[0023] The at least one hydrophilic compound is selected from a group comprising of glycerol, levulinic acid, sorbic acid and their potassium or sodium salts, phytols, polyphenols, plant extracts, biopolysaccharides, sugars and emulsifiers.

[0024] In an embodiment, the nano-emulsion composition includes at least one water soluble phytoactive compound. The at least one water soluble phytoactive compound is present in a percentage of between 0.5 % and 5 % by weight, preferably 1.5 % by weight, based on total weight of the nano-emulsion composition. 02 04 25

[0025] The at least one water soluble phytoactive compound is selected from a group comprising of Glycyrrhiza Glabra extract, Mango fruit extract, Moris Alba root extract, poppy seed extract, Centella Asiatica leaf extract and forsythoside B from plant extract.

[0026] The at least one water soluble phytoactive compound exhibit good skin care benefits. As according to the National Cancer Institute Glycyrrhiza Glabra extract has been used as an anti-inflammatory and antioxidant, primarily because of licochalcone, a molecule contained in liquorice root extract which helps control oil production and helps calm and soothe acne-prone skin.

[0027] The Mango fruit extract exhibit hydrating properties, as mangoes are full of antioxidants which is an amazing property in keeping the skin nourished, improving skin tone, providing healthy skin, preventing acne breakouts, soothing skin, promoting collagen production and brightening skin.

[0028] The Moris Alba root extract’s main benefit for skin being calming signs of irritation along with its potential to fade the look of discolorations and uneven skin tone.

[0029] The poppy seed extract helps to restore the natural barrier and reduces trans epidermal water loss. The poppy seed extract is a natural emollient. The poppy seed extract also helps to soften and conditioning the hair whilst locking in moisture, hydrating and improving hair health and providing a non-greasy shine.

[0030] The Centella Asiatica leaf extract boosts antioxidant activity at the site of wounds, strengthening the skin and increasing blood circulation. The Centella Asiatica leaf extract is beneficial in the management of eczema, psoriasis, veins, and stretch marks. For acne sufferers, the Centella Asiatica leaf extract speeds healing, helping to prevent scarring and prevent future blemishes.

[0031] The forsythoside B from plant extract protects against the entry of particulate matter into the skin, removes and neutralizes damaging free radicals, 02 04 25 strengthens the skin’s barrier function by 18.6% versus control after exposure to particulate matter, repairs cell metabolism by boosting adenosine triphosphate (ATP) production.

[0032] In an embodiment, the nano-emulsion composition includes at least one oil soluble phytoactive compound. The at least one oil soluble phytoactive compound is present in a percentage of between 0.01 % and 5 % by weight, preferably 0.2 % by weight, based on total weight of the nano-emulsion composition.

[0033] The at least one oil soluble phytoactive compound is selected from a group comprising of phytol extracted from plant, boswellin and NG shea unsaponifiable.

[0034] The phytol extracted from plant reduces signs of skin aging of the face and body by stimulating adipogenesis and lipogenesis, and further stimulating collagen, elastin and extracellular matrix production. The boswellin has a skinsoothing effect.

[0035] The NG shea unsaponifiable soothes inflamed lips and rebuilds the lip integrity by strengthening the epidermis, restoring the barrier function and improving the moisture level. The NG shea unsaponifiable repairs damaged lips, making lips comfortable, soft and evenly pink.

[0036] In an embodiment, the nano-emulsion composition includes a combination of polyglycerol fatty acid esters as emulsifiers. The combination of polyglycerol fatty acid esters comprise a first polyglycerol fatty acid ester and a second polyglycerol fatty acid ester in a ratio of 50:50. The first polyglycerol fatty acid ester having number of carbon atoms and mean polymerisation degree represented by C12G10 , and the second polyglycerol fatty acid ester having number of carbon atoms and mean polymerisation degree represented by CisuGio. 02 04 25

[0037] In an exemplary embodiment, the combination of polyglycerol fatty acid esters comprises the first polyglycerol fatty acid ester and the second polyglycerol fatty acid ester preferably in a ratio of 50:50.

[0038] In yet another exemplary embodiment, polyglycerol-10 laurate (C12G10) and polyglycerol-10 oleate or polyglyceryl-10 oleate (CisiiGio) being used as the first polyglycerol fatty acid ester and the second polyglycerol fatty acid ester, respectively. The polyglyceryl-10 laurate functions as a skin-softening emulsifier and cleansing agent. The polyglyceryl-10 oleate is an ester of decaglycerol and oleic acid and functions as a hydrating ingredient and emulsifier.

[0039] The combination of polyglycerol fatty acid esters is present in a percentage of between 1 % and 10 % by weight, preferably 4 % by weight, based on total weight of the nano-emulsion composition.

[0040] As used herein the term ‘emulsifier’ refers to a substance that stabilizes an emulsion, in particular an additive used to stabilize the creams, skin care products and processed food.

[0041] Further in an embodiment, the nano-emulsion composition includes at least one preservative. The at least one preservative is present in a percentage of between 0.5 % and 4 % by weight, preferably 1.5 % by weight, based on total weight of the nano-emulsion composition. The at least one preservative is selected from a group comprising of sodium levulinate, potassium sorbate and anisic acid.

[0042] In another embodiment of the present invention, a skin care composition comprising the nano-emulsion composition is provided. The skin care composition can be prepared by blending the above components and then dissolving, mixing or dispersing them by a conventional method.

[0043] In yet another embodiment of the present invention, a cosmetic comprising the nano-emulsion composition is provided. The cosmetic can be prepared by blending the above components and then dissolving, mixing or dispersing them by a conventional method according to the embodiment of the cosmetic.

[0044] In the present invention different ratios of the first polyglycerol fatty acid ester (C12G10) and the second polyglycerol fatty acid ester (CisoGio) were analysed to study optimum characteristics of the emulsion composition. Table 2 enlists the different ratios of the C12G10 and the CisjGio and characteristics studied. 02 04 25 Ratio of C12G10 and Cis:iGio in emulsion Composition Emulsion Characteristics % T 70:30 Cloudy <40 % 60:40 Clear > 60 % but <75 % 50:50 Clear > 85 % 40:60 Cloudy <40 % 30:70 Cloudy <20 % Table 2

[0045] According to analysis the emulsion composition comprising the C12G10 and the CistGio in the ratio of 50:50 by weight (1:1) exhibits optimum characteristics i.e. clear emulsion composition with >85 % transparency (T). The emulsion composition comprising the C12G10 and the Ci8:iGio in the ratio of 60:40 by weight (3:2) also exhibits clear emulsion composition with >60% but <75 % transparency.

[0046] The present invention provides the nano-emulsion composition for skin care application and cosmetics. The nano-emulsion composition being oil in water emulsion composition with a transparency >75 % for visible light. The invention provides a stable, homogeneous, aqueous fluid product incorporating waterinsoluble phytoactives into the nano-emulsion composition. The invention also provides an emollient which exhibits silky feel to the skin by virtue of proprietary 02 04 25 oil incorporation into the nano-emulsion composition. The nano-emulsion composition being a low viscous fluidic vehicle to be used as Serum, Micellar Water, Facial Cleanser etc The COSMetic Organic and Natural Standard (COSMOS) has certified the nano-emulsion composition being natural. The nanoemulsion composition being capable of retaining high storage stability over a wider temperature range.

[0047] While specific language has been used to describe the disclosure, any limitations arising on account of the same are not intended. As would be apparent to a person skilled in the art, various working modifications may be made to the method in order to implement the inventive concept as taught herein.

[0048] The figures and the foregoing description give examples of embodiments. Those skilled in the art will appreciate that one or more of the described elements may well be combined into a single functional element. Alternatively, certain elements may be split into multiple functional elements. Elements from one embodiment may be added to another embodiment. Moreover, the actions of any flow diagram need not be implemented in the order shown; nor do all of the acts need to be necessarily performed. Also, those acts that are not dependant on other acts may be performed in parallel with the other acts. The scope of embodiments is by no means limited by these specific examples.

Claims

02 04 251. A nano-emulsion composition for skin care application, comprising:at least one oil;at least one hydrophilic compound;at least one water soluble phytoactive compound;at least one oil soluble phytoactive compound;at least one preservative; anda combination of polyglycerol fatty acid esters as emulsifiers,characterised in that the combination of polyglycerol fatty acid esters comprise a first polyglycerol fatty acid ester and a second polyglycerol fatty acid ester in a ratio of 50:50, wherein the first polyglycerol fatty acid ester having number of carbon atoms and mean polymerisation degree represented by C12G10, and the second polyglycerol fatty acid ester having number of carbon atoms and mean polymerisation degree represented by Ci8:iGio;wherein the at least one oil is present in an amount of >4 % by weight, based on total weight of the nano-emulsion composition;wherein the at least one hydrophilic compound is present in an amount between 0.1 % and 15% by weight, based on total weight of the nanoemulsion composition;wherein the at least one water soluble phytoactive compound is present in an amount between 0.5 % and 5 % by weight, based on total weight of the nano-emulsion composition;02 04 25wherein the at least one oil soluble phytoactive compound is present in an amount between 0.01 % and 5 % by weight, based on total weight of the nano-emulsion composition;wherein the combination of polyglycerol fatty acid esters is present in an amount between 1 % and 10 % by weight, based on total weight of the nanoemulsion composition;wherein the at least one preservative is present in an amount between 0.5 % and 4 % by weight, based on total weight of the nano-emulsion composition;wherein the at least one oil is configured as a dispersed phase in the oil-in-water nano-emulsion composition, and comprises oil droplets of size 100 -300 nm;wherein the nano-emulsion composition being oil in water emulsion composition with a transparency >75% for visible light; andwherein the oil droplets comprise phytoactive solubilised in the oil droplets mono-dispersed in the nano-emulsion composition.

2. The nano-emulsion composition as claimed in claim 1, wherein the at least one oil is selected from a group consisting hydrocarbons, fatty esters, fatty carbonates and triglycerides.

3. The nano-emulsion composition as claimed in claim 1, wherein the at least one oil is selected from a group consisting C15-19 Alkane, Undecane and Tridecane, Capric Caprylic Triglyceride, Coco caprylate or Coco caprate, Dicaprylyl carbonate, Cetyl Ricinoleate, and Isoamyl Cocoate.

4. The nano-emulsion composition as claimed in claim 1, wherein the at least one hydrophilic compound is selected from a group comprising of glycerol, levulinic acid, sorbic acid and their potassium or sodium salts, phytols, polyphenols, plant extracts, bioopolysaccharides, sugars and emulsifiers.02 04 255. The nano-emulsion composition as claimed in claim 1, wherein the at least one water soluble phytoactive compound is selected from a group comprising of Glycyrrhim Glabra extract, Mango fruit extract, Moris Alba root extract, poppy seed extract, Centella Asiatica leaf extract and forsythoside B from plant extract.

6. The nano-emulsion composition as claimed in claim 1, wherein the at least one oil soluble phytoactive compound is selected from a group comprising phytol derived from plant extract, boswellin and NG shea unsaponifiable.

7. The nano-emulsion composition as claimed in claim 1, wherein the at least one preservative is selected from a group comprising of sodium levulinate, potassium sorbate and anisic acid.

8. A skin care composition, comprising the nano-emulsion composition of any one of claims 1 to 7.

9. A cosmetic, comprising the nano-emulsion composition of any one of claims 1 to 8.