Method for controlling shape of skin

Abstract

To provide a method for controlling a shape of skin.SOLUTION: Provided is a method for controlling a shape of skin after removing a composition comprising the following components (A) and (B): (A) a polymer whose deformation ratio measured by the following method (1) is 0.3 or more and 1 or less. In the method (1), a 10 mass% hexamethyldisiloxane solution of said polymer is prepared, and 0.005 g of the solution is applied to one side of a polyethylene sheet 20 mm wide×100 mm long×0.03 mm thick, 20 mm wide×50 mm long from one end of the short side in the longitudinal direction, and dried in a thermostatic bath set at 40°C for 10 minutes. The length of the polyethylene sheet in the area where the solution is applied is L1, the length of the polyethylene sheet in the area deformed by shrinkage after drying is L2, and the value L2 / L1 is the deformation ratio. (B) A step of applying the composition multiple times topically and a step of removing the composition after each application are repeated such that a composition containing a volatile oil with a volatility of 14% or more after drying for 30 minutes at 40°C and 60% R.H. under 1 atmosphere is applied to the desired skin area for a period of 7 days or more, and the cumulative application time is 28 hours or more for the 7 days.SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to a method for controlling the shape of the skin.

Background Art

[0002] With aging, the degree of wrinkles in human skin becomes stronger. This is part of the aging phenomenon of the skin and is influenced by multiple factors such as changes in skin tissue and the effects of exposure to ultraviolet rays. Conventionally, skin care products for making skin wrinkles less noticeable have been studied, but their improvement effect is low, and the satisfaction of women with wrinkle problems has not been obtained. In addition, methods for controlling the shape of the skin and making skin wrinkles less noticeable have been studied. For example, Patent Document 1 describes a method for improving skin wrinkles by applying a composition containing a polymer having a specific deformation ratio and a volatile oil to the skin.

Prior Art Documents

Patent Documents

[0003]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0004] However, in the conventional method, although wrinkles are improved when the composition is applied, the effect is not obtained after the composition is removed, and it does not fundamentally improve wrinkles.

Means for Solving the Problems

[0005] The present inventors have found that by applying a composition containing a polymer having a specific deformation ratio and a volatile oil to a target area of the skin by a specific method, the shape of the skin can be fundamentally suppressed even after the composition is removed.

[0006] The present invention relates to the following components (A) and (B): (A) A polymer whose deformation ratio measured by the method (1) below is 0.3 or more and 1 or less. Method (1): Prepare a 10% by mass hexamethyldisiloxane solution of the polymer. Apply 0.005 g of the solution to one side of a polyethylene sheet measuring 20 mm wide x 100 mm long x 0.03 mm thick, from one end of the short side in the longitudinal direction, to an area measuring 20 mm wide x 50 mm long, and dry in a constant temperature bath set to 40°C for 10 minutes. Let L1 be the length of the polyethylene sheet in the area where the solution was applied, and L2 be the length of the polyethylene sheet in the area deformed by shrinkage after drying, and the value L2 / L1 be the deformation ratio. (B) Volatile oils with a volatility of 14% or more after drying for 30 minutes at 1 atmosphere, 40°C, and 60% RH. The present invention relates to a method for controlling the shape of skin after removal of a composition, characterized by repeating the steps of: applying a composition containing the composition to a target area of ​​skin multiple times locally for a period of 7 days or more, with a cumulative application time of 28 hours or more over 7 days; and removing the composition after each application.

[0007] Furthermore, the present invention relates to the following components (A) and (B): (A) A polymer whose deformation ratio measured by the method (1) below is 0.3 or more and 1 or less. Method (1): Prepare a 10% by mass hexamethyldisiloxane solution of the polymer. Apply 0.005 g of the solution to one side of a polyethylene sheet measuring 20 mm wide x 100 mm long x 0.03 mm thick, from one end of the short side in the longitudinal direction, to an area measuring 20 mm wide x 50 mm long, and dry in a constant temperature bath set to 40°C for 10 minutes. Let L1 be the length of the polyethylene sheet in the area where the solution was applied, and L2 be the length of the polyethylene sheet in the area deformed by shrinkage after drying, and the value L2 / L1 be the deformation ratio. (B) Volatile oils with a volatility of 14% or more after drying for 30 minutes at 1 atmosphere, 40°C, and 60% RH. The present invention relates to a method for improving wrinkles in the skin after removal of a composition, characterized by repeating the steps of: applying a composition containing the above to a target area of ​​skin multiple times locally for a period of 7 days or more, with a cumulative application time of 28 hours or more over 7 days; and removing the composition after each application. [Effects of the Invention]

[0008] According to the present invention, the shape of the skin can be fundamentally controlled. In the present invention, "controlling the shape of the skin" means improving wrinkles and sagging of the skin, such as making nasolabial folds (smile lines), crow's feet, forehead wrinkles, and frown lines less noticeable, or improving sagging of the cheeks. [Brief explanation of the drawing]

[0009] [Figure 1] This is an explanatory diagram of the method for evaluating the polymer deformation ratio (L2 / L1) using method (1). [Figure 2] This figure shows the area to be measured for surface shape in Example 3. [Figure 3] This figure shows the depth of wrinkles after 8 weeks of continuous use in Example 3. [Figure 4] This figure shows the depth of wrinkles one week after the end of continuous use in Example 3. [Figure 5] This figure shows the change in Ra of nasolabial folds in Example 4. [Figure 6] This figure shows the change in the length of nasolabial folds in Example 4. [Figure 7] This figure shows the change in the depth of nasolabial folds in Example 4. [Figure 8] This figure shows the change in the visibility of nasolabial folds in Example 4. [Figure 9] This figure shows the change in Ra of crow's feet wrinkles in Example 5. [Figure 10] This figure shows the change in Ra of forehead wrinkles in Example 6. [Figure 11]This figure shows the change in Ra of frown lines in Example 7. [Figure 12] This figure shows the change in the cheek sagging score in Example 8. [Modes for carrying out the invention]

[0010] <Ingredient (A)> The component (A) used in the present invention is a polymer whose deformation ratio, as measured by method (1) above, is 0.3 or more and 1 or less. The method for evaluating the deformation ratio (L2 / L1) of component (A) according to method (1) described above will be explained with reference to Figure 1. First, a 10% by mass hexamethyldisiloxane solution of component (A) used in the composition is prepared. 0.005 g of this solution is applied to one side of a polyethylene sheet 1, which is 20 mm wide (W) × 100 mm long (L0) × 0.03 mm thick, as shown in Figure 1(a), in an area of ​​20 mm wide × 50 mm long (part 2 shown in Figure 1(a)) extending from one end 1a of the short side of the polyethylene sheet 1 in the longitudinal direction, and is dried in a constant temperature bath set to 40°C for 10 minutes. Figure 1(b) is a schematic diagram of a polyethylene sheet that has been dried and in which a part of it has been deformed (curled) due to the shrinkage of the polymer, which is component (A). In the dried polyethylene sheet (Figure 1(b)), the length of the polyethylene sheet in the area where the solution was applied is L1 (50 mm), and the length of the polyethylene sheet in the area deformed by shrinkage after drying is L2. The ratio L2 / L1 is calculated and this value is taken as the deformation ratio. L2 is the average of the values ​​measured on the two long sides of polyethylene sheet 1. A larger value of L2 / L1 indicates a greater amount of shrinkage of the polymer due to drying, and the upper limit of L2 / L1 is 1.

[0011] From the viewpoint of controlling the shape of the skin and improving wrinkles and sagging of the skin, the deformation ratio L2 / L1 of component (A) evaluated by method (1) is 0.3 or more, preferably 0.5 or more, more preferably 0.6 or more, even more preferably 0.7 or more, even more preferably 0.8 or more, even more preferably 0.85 or more, even more preferably 0.9 or more, and even more preferably 0.95 or more, with an upper limit of 1. The deformation ratio can be specifically evaluated by the method described in the examples.

[0012] The polymer of component (A) can be used, but is limited to those that satisfy the aforementioned deformation ratio. Examples of basic structural components of component (A) include condensation polymers such as polyurethane, polyester, polyether, and polyurea; vinyl polymers obtained by addition polymerization of vinyl monomers such as vinyl compounds, vinylidene compounds, vinylene compounds, and cyclic olefins; and silicone polymers. Among these, one or more selected from vinyl polymers and silicone polymers are preferred from the viewpoint of controlling the apparent shape of the skin and improving wrinkles and sagging of the skin.

[0013] The vinyl monomers constituting the vinyl polymer are preferably those having anionic or cationic groups. Anionic groups include carboxyl groups (-COOM), sulfonic acid groups (-SO3M), phosphate groups (-OPO3M2), etc., which exhibit acidity when they dissociate and release hydrogen ions, or their dissociated ionic forms (-COO3M2). - , -SO3 - ,-OPO3 2- ,-OPO3 - Examples include M). In the above chemical formula, M represents a hydrogen atom, an alkali metal, an ammonium, or an organic ammonium. Examples of vinyl monomers having anionic groups include acrylic acid, methacrylic acid, maleic acid, and styrene sulfonic acid. Examples of cationic groups include protonates of primary, secondary, or tertiary amino groups, and quaternary ammonium groups. Examples of vinyl monomers having cationic groups include N,N-dimethylaminoethyl (meth)acrylate and N,N-dimethylaminopropyl (meth)acrylamide. The vinyl polymer is preferably a vinyl polymer containing repeating units derived from a vinyl monomer having an anionic group, from the viewpoint of controlling the apparent shape of the skin and improving wrinkles and sagging of the skin; more preferably a vinyl polymer containing repeating units derived from one or more vinyl monomers selected from acrylic acid, methacrylic acid, maleic acid, styrene sulfonic acid and salts thereof; and even more preferably one or more selected from polymethacrylic acid and sodium polystyrene sulfonate. The vinyl polymer may be a copolymer containing repeating units derived from vinyl monomers having anionic groups, as well as repeating units derived from other monomers. However, from the viewpoint of controlling the apparent shape of the skin and improving wrinkles and sagging, it is preferable that it be a homopolymer of vinyl monomers having anionic groups.

[0014] The weight-average molecular weight Mw of the vinyl polymer is preferably 10,000 or more, more preferably 30,000 or more, even more preferably 50,000 or more, and preferably 700,000 or less, more preferably 500,000 or less, and even more preferably 300,000 or less. The weight-average molecular weight Mw can be measured by gel permeation chromatography (GPC) using polystyrene as a standard substance, and specifically by the method described in the examples. Vinyl polymers may be synthesized or commercially available. When vinyl polymers are obtained by synthesis, for example, they can be obtained by known addition polymerization methods of vinyl monomers having the aforementioned anionic groups and, if necessary, other monomers, in the presence of a polymerization initiator. Examples of commercially available vinyl polymers include sodium polystyrene sulfonate manufactured by Alfa Aesar.

[0015] Furthermore, among component (A), the silicone polymer is preferably a silicone polymer having a silicone structure. In the present invention, "silicone structure" refers to a structure represented by the following general formula (I).

[0016] [ka]

[0017] In general formula (I), R 1 Each of these is an independent hydrocarbon group having 1 to 12 carbon atoms, and p is an integer of 1 or more. From the perspective of controlling the visible shape of the skin when applied and improving wrinkles and sagging of the skin (hereinafter also referred to as the "effect of controlling the shape of the skin") and from the perspective of versatility, R 1 Preferably, the group is an alkyl group having 1 to 12 carbon atoms or an aryl group having 6 to 12 carbon atoms, more preferably an alkyl group having 1 to 12 carbon atoms or a phenyl group, even more preferably an alkyl group having 1 to 3 carbon atoms, and even more preferably a methyl group.

[0018] The polymer of component (A) only needs to have a silicone structure, and may consist solely of a silicone structure. However, from the viewpoint of obtaining a polymer with the predetermined properties, it is preferable that the polymer has a silicone structure in part. In the case of a polymer having a silicone structure in part, the silicone structure may be present in the main chain or the side chains of the polymer, and from the viewpoint of obtaining a polymer with the predetermined properties, it is preferable that it be present in the side chains. When a silicone structure is present in the polymer backbone, there are no particular restrictions on its bonding configuration. For example, the silicone structure may be located at the ends of the polymer backbone, or the copolymer may have silicone structures bonded to the polymer backbone in a block-like or random manner. Furthermore, polymers graft-modified with compounds containing silicone structures can also be used.

[0019] Component (A) is preferably a silicone-modified polymer, and specific examples include silicone-modified polymers containing norbornane structures such as silicone-modified polynorbornene; silicone-modified pullulan; silicone-structure-containing silicate compounds such as trialkylsiloxysilicate, fluorine-modified alkylsiloxysilicate, and phenyl-modified alkylsiloxysilicate; and silicone dendrimers.

[0020] (Norbornane-containing silicone-modified polymer) In the present invention, the norbornane structure refers to the structure shown in the following formula. The norbornane structure-containing silicone-modified polymer is any silicone-modified polymer having the structure shown in the formula at any part of the polymer.

[0021] [ka]

[0022] Examples of norbornane structure-containing silicone-modified polymers include polymers having repeating units represented by the following general formulas (1) or (2).

[0023] [ka]

[0024] In the formula, R 2 Each of these is an alkyl group having between 1 and 12 carbon atoms, and X is a group represented by the following formula (i). a is an integer between 1 and 3, and b is an integer between 0 and 2.

[0025] [ka]

[0026] In the formula, R 1 The same as above, and c is an integer between 1 and 5 (inclusive).

[0027] [Chemical formula]

[0028] In the formula, R 1 , R 2 and b are the same as described above, and d is an integer of 2 or more and 5 or less.

[0029] In the general formula (1), R 2 are each independently an alkyl group having 1 to 12 carbon atoms. From the viewpoint of controlling the shape of the skin, a methyl group, an ethyl group, an n-propyl group, a butyl group, or a pentyl group is preferable, and a methyl group is more preferable. X is a group represented by the above formula (i). In the formula (i), R 1 are each independently a hydrocarbon group having 1 to 12 carbon atoms. From the viewpoint of controlling the shape of the skin, R 1 is preferably an alkyl group having 1 to 12 carbon atoms or an aryl group having 6 to 12 carbon atoms, more preferably an alkyl group having 1 to 12 carbon atoms or a phenyl group, still more preferably an alkyl group having 1 to 3 carbon atoms, and even more preferably a methyl group. c is an integer of 1 or more and 5 or less. From the viewpoint of versatility, c = 1 is preferable. That is, X is preferably a trimethylsiloxy group. a is an integer of 1 or more and 3 or less. For example, it may be a polymer in which repeating units of a = 2 and repeating units of a = 3 are mixed and present. From the viewpoint of versatility, a is preferably 3. b is an integer of 0 or more and 2 or less. From the same viewpoint, it is preferably 0, 1 or a combination thereof, and 0 is more preferable.

[0030] In the general formula (2), R 1 , R 2 and b are the same as described above. d is an integer of 2 or more and 5 or less. From the viewpoint of versatility, d = 2 is preferable. The cyclic silicone structure in the general formula (2) is, from the same viewpoint, R <着 1 and R 2 are methyl groups, and d is preferably 2 or 3. That is, the cyclic silicone structure in the general formula (2) is preferably a structure represented by the following formula (4) or (5).

[0031] [ka]

[0032] From the viewpoint of controlling the shape of the skin, the proportion of repeating units represented by the general formula (1) or (2) in the norbornane structure-containing silicone-modified polymer is preferably 10% or more, more preferably 30% or more, and even more preferably 50% or more of the total number of repeating units in the polymer. The upper limit is 100%, preferably 95% or less, more preferably 90% or less, and even more preferably 70% or less. The specific range of the number of repeating units represented by the general formula (1) or (2) in the norbornane structure-containing silicone-modified polymer is preferably 10 to 100%, more preferably 10 to 95%, even more preferably 30 to 90%, and even more preferably 50 to 70% of the total number of repeating units in the polymer.

[0033] The norbornane structure-containing silicone-modified polymer may have, in addition to the repeating unit represented by the general formula (1) or (2) above, a repeating unit represented by the following general formula (3).

[0034] [ka]

[0035] In the formula, R 3 ~R 6 Each of these is independently a hydrogen atom, a halogen atom, a substituent selected from alkyl groups, alkenyl groups, cycloalkyl groups, aryl groups, alkoxy groups, aryloxy groups, and halogenated hydrocarbon groups having 1 to 10 carbon atoms, or an oxetanyl group, alkoxycarbonyl group, polyoxyalkylene group, polyglyceryl group, or alkoxysilyl group. 3 ~R 6 Two groups selected from may bond to each other to form an alicyclic structure, an aromatic ring structure, a carboimide group, or an acid anhydride group. b is the same as described above.

[0036] The proportion of repeating units represented by the above general formula (3) in the norbornane structure-containing silicone-modified polymer is preferably 90% or less, more preferably 70% or less, and even more preferably 50% or less of the total number of repeating units in the polymer, from the viewpoint of controlling the shape of the skin. Furthermore, if the repeating units represented by the above general formula (3) are included, their proportion is preferably 5% or more, more preferably 10% or more, and even more preferably 30% or more of the total number of repeating units in the polymer. The specific range of the number of repeating units represented by the above general formula (3) in the norbornane structure-containing silicone-modified polymer is preferably 5 to 90%, more preferably 10 to 70%, and even more preferably 30 to 50% of the total number of repeating units in the polymer. The proportion of repeating units represented by the above general formulas (1) to (3) in the norbornane structure-containing silicone-modified polymer is: 1 This can be determined by 1H-NMR measurement.

[0037] As the norbornane structure-containing silicone-modified polymer, silicone-modified polynorbornene is preferred, and more preferably, silicone-modified polynorbornene represented by the following formula (6).

[0038] [ka]

[0039] In the formula, e and f are repeating units, and are independent integers greater than or equal to 1. From the viewpoint of improving skin wrinkles, the ratio of e and f in general formula (6) is preferably e / f = 20 / 80 to 90 / 10 (mol / mol), more preferably 30 / 70 to 80 / 20 (mol / mol), and even more preferably 50 / 50 to 70 / 30 (mol / mol).

[0040] The number-average molecular weight Mn of the norbornane structure-containing silicone-modified polymer is preferably 50,000 or more, more preferably 100,000 or more, even more preferably 200,000 or more, preferably 2,000,000 or less, more preferably 1,500,000 or less, even more preferably 800,000 or less, and even more preferably 600,000 or less, from the viewpoint of shrinkage, control of skin shape, and effect on improving skin wrinkles. The specific range of the number-average molecular weight Mn of the norbornane structure-containing silicone-modified polymer is preferably 50,000 to 2,000,000, more preferably 100,000 to 1,500,000, even more preferably 200,000 to 800,000, and even more preferably 200,000 to 600,000. The number-average molecular weight Mn of the polymer can be measured by gel filtration chromatography (GPC) using polystyrene as a standard substance, specifically by the method described in the examples.

[0041] Norbornane structure-containing silicone-modified polymers can be obtained, for example, by addition polymerization of a silicone-modified cyclic olefin monomer containing or capable of forming a norbornane structure using a known method. For example, a silicone-modified polymer containing a norbornane structure having repeating units represented by the general formula (1) or (2) can be obtained by addition polymerization of a cyclic olefin monomer represented by the following general formula (1a) or (2a). Furthermore, a cyclic olefin monomer represented by the following general formula (3a) may be copolymerized.

[0042] [ka]

[0043] In the formula, R 1 Each of these is an alkyl group having between 1 and 12 carbon atoms, and X is a group represented by the following formula (i). a is an integer between 1 and 3, and b is an integer between 0 and 2.

[0044] [ka]

[0045] In the formula, R 2 Each of these is an independent hydrocarbon group having between 1 and 12 carbon atoms, and c is an integer between 1 and 5.

[0046] [ka]

[0047] In the formula, R 1 , R 2 And b are the same as described above, and d is an integer between 2 and 5 (inclusive).

[0048] [ka]

[0049] In the formula, R 3 ~R 6 Each of these is independently a hydrogen atom, a halogen atom, a substituent selected from alkyl groups, alkenyl groups, cycloalkyl groups, aryl groups, alkoxy groups, aryloxy groups, and halogenated hydrocarbon groups having 1 to 10 carbon atoms, or an oxetanyl group, alkoxycarbonyl group, polyoxyalkylene group, polyglyceryl group, or alkoxysilyl group. 3 ~R 6 Two groups selected from may bond to each other to form an alicyclic structure, an aromatic ring structure, a carboimide group, or an acid anhydride group. b is the same as described above.

[0050] When copolymerizing the cyclic olefin monomer represented by the above general formula (3a), the amount used is preferably 90 mol% or less, more preferably 70 mol% or less, even more preferably 50 mol% or less, and also preferably 5 mol% or more, more preferably 10 mol% or more, and even more preferably 30 mol% or more, based on the total monomer used for polymerization being 100 mol%, from the viewpoint of shrinkage, control of skin shape, and effect on improving skin wrinkles.

[0051] The silicone-modified polynorbornene represented by formula (6) can be obtained by addition polymerization of tris(trimethylsiloxy)silylnorbornene represented by formula (6a) below and norbornene.

[0052] [ka]

[0053] From the viewpoint of contractility, control of skin shape, and improvement of skin wrinkles, the copolymerization ratio of tris(trimethylsiloxy)silylnorbornene to norbornene is preferably 20 / 80 to 90 / 10 (mol / mol), more preferably 30 / 70 to 80 / 20 (mol / mol), and even more preferably 50 / 50 to 70 / 30 (mol / mol).

[0054] The repeating units shown in the general formulas (1) to (3) and formula (6) all represent 2,3-addition structural units of the cyclic olefin monomer, which is the raw material monomer. However, some of these may be 2,7-addition structural units resulting from the addition polymerization of the cyclic olefin monomer.

[0055] As the norbornane structure-containing silicone-modified polymer, norbornane / tris(trimethylsiloxy)silylnorbornene copolymer is preferred, and is a compound denoted by the INCI name (International Cosmetic Ingredient Dictionary and Handbook, 16th edition, Vol. 2, 2016, p. 2274): NORBORNENE / TRIS(TRIMETHYLSILOXY)SILYLNORBORNENE COPOLYMER. Examples of commercially available silicone-modified polymers containing norbornane structures include Shin-Etsu Chemical Co., Ltd.'s "NBN-30-ID" (an isododecane solution of norbornane / tris(trimethylsiloxy)silylnorbornene) copolymer).

[0056] (Silicone-modified pullulan) Examples of silicone-modified pullulans include pullulans having a silicone structure in their side chains. Specifically, from the viewpoint of controlling the shape of the skin, silicone-modified pullulans in which at least some of the hydrogen atoms of the OH groups in the pullulan are replaced with a group represented by the following general formula (7) are preferred.

[0057] [ka]

[0058] In the formula, Z 1 R is a single bond or a divalent organic group. 2 X and a are the same as described above, and from a similar viewpoint, X is preferably a trimethylsiloxy group and a is preferably 3.

[0059] In general formula (7), from a similar perspective, Z 1 It is preferably a divalent organic group, more preferably a divalent group represented by the following general formula (8) or (9), and more preferably a divalent group represented by the following general formula (9).

[0060] [ka]

[0061] In the formula, R 11 The alkylene group has 1 to 10 carbon atoms, and examples include the methylene group, ethylene group, trimethylene group, propylene group, and butylene group. From a similar viewpoint, among these, the ethylene group, trimethylene group, and propylene group are preferred, and the trimethylene group or propylene group is more preferred.

[0062] Examples of commercially available silicone-modified pullulans include "TSPL-30-ID" (isododecane solution of tri(trimethylsiloxy)silylpropylcarbamate pullulan) and "TSPL-30-D5" (cyclopentasiloxane solution of tri(trimethylsiloxy)silylpropylcarbamate pullulan), both manufactured by Shin-Etsu Chemical Co., Ltd.

[0063] (Silicate compound containing silicone structure) Examples of silicone structure-containing silicate compounds used in the present invention include silicate compounds having a silicone structure at the terminal end, such as trialkylsiloxysilicate, fluorine-modified alkylsiloxysilicate, and phenyl-modified alkylsiloxysilicate. In trialkylsiloxysilicate, the alkyl group is preferably a group having 1 to 10 carbon atoms, more preferably 1 to 4 carbon atoms, and even more preferably a methyl group, from the viewpoint of controlling the shape of the skin. A specific example of trialkylsiloxysilicate is trimethylsiloxysilicate. Examples of fluorine-modified alkylsiloxysilicates include compounds in which at least some of the hydrogen atoms of the alkyl group in trialkylsiloxysilicate are replaced with fluorine atoms. Specific examples include trifluoropropyldimethylsiloxysilicate and trifluoropropyldimethyl / trimethylsiloxysilicate. Examples of phenyl-modified alkylsiloxysilicates include phenylpropyldimethylsiloxysilicate and phenylpropyldimethyl / trimethylsiloxysilicate.

[0064] Among silicone structure-containing silicate compounds, from the viewpoint of controlling skin shape, one or more selected from the group consisting of trialkylsiloxysilicate and fluorine-modified alkylsiloxysilicate are preferred.

[0065] Commercially available silicone structure-containing silicate compounds that can be used include trimethylsiloxysilicate (solution) such as "KF-7312J", "KF-7312K", "KF-7312T", "KF-7312L", "X-21-5249", "X-21-5250", "KF-9021", "X-21-5595", "X-21-5616", "KF-9021L", "X-21-5249L", and "X-21-5250L" manufactured by Shin-Etsu Chemical Co., Ltd., as well as "XS66-B8226" (cyclopentasiloxane solution of trifluoropropyldimethyl / trimethylsiloxysilicate), "XS66-B8636" (dimethicone solution of trifluoropropyldimethyl / trimethylsiloxysilicate), and "SilShine151" (phenylpropyldimethylsiloxysilicate) manufactured by Momentive Performance Materials Japan LLC.

[0066] (Silicone dendrimer) Examples of silicone dendrimers include vinyl polymers having a siloxane dendrimer structure in their side chains. From the viewpoint of controlling the shape of the skin, the siloxane dendrimer structure is preferably a group represented by the following general formula (10).

[0067] [ka]

[0068] In the formula, R 1 This is the same as above. Z 2 X is a single bond or a divalent organic group. 1 is a base represented by the following general formula (11) when i=1, where i is an integer between 1 and 10 that indicates the hierarchy of the base.

[0069] [ka]

[0070] In the formula, R 1 This is the same as above, and R 12Z is an alkyl group having 1 to 10 carbon atoms. 3 X is an alkylene group having 2 to 10 carbon atoms. i+1 a is a hydrogen atom, an alkyl group having 1 to 10 carbon atoms, an aryl group, or a group represented by general formula (11), i is an integer between 0 and 3 (inclusive).

[0071] In general formula (10), Z 2 The group is a single bond or a divalent organic group, and from the viewpoint of versatility, it is preferably a divalent organic group, and more preferably a divalent group represented by the following general formulas (12), (13), or (14).

[0072] [ka]

[0073] In the formula, R 13 R is an alkylene group having 1 to 10 carbon atoms, and examples include a methylene group, ethylene group, trimethylene group, propylene group, butylene group, etc., and from the viewpoint of versatility, an ethylene group, trimethylene group, or propylene group is preferred. 14 R is an alkyl group having 1 to 10 carbon atoms, with methyl, ethyl, propyl, and butyl groups being examples, and from a similar viewpoint, the methyl group is preferred. 15 is an alkylene group having 1 to 10 carbon atoms, with examples including a methylene group, ethylene group, trimethylene group, propylene group, and butylene group, and from a similar viewpoint, an ethylene group is preferred. q is an integer between 0 and 4, and r is 0 or 1.

[0074] Examples of vinyl polymers having the siloxane dendrimer structure described above in their side chains (hereinafter also simply referred to as "vinyl polymers") include polymers having repeating units derived from monomers represented by the following general formula (15).

[0075] [ka]

[0076] In the formula, R 1 and X 1 The same applies as described above. Y is a group containing a vinyl bond, and examples include a vinyl group, 2-acryloyloxyethyl group, 3-acryloyloxypropyl group, 2-methacryloyloxyethyl group, 3-methacryloyloxypropyl group, 4-vinylphenyl group, 3-vinylphenyl group, 4-(2-propenyl)phenyl group, 3-(2-propenyl)phenyl group, 2-(4-vinylphenyl)ethyl group, 2-(3-vinylphenyl)ethyl group, allyl group, and 5-hexenyl group. Of these, from the viewpoint of versatility, a (meth)acryloyl group or a vinyl group is preferred, and a (meth)acryloyl group is more preferred.

[0077] The vinyl polymer may further contain repeating units derived from vinyl monomers other than the monomer represented by the general formula (15). The vinyl monomer is a monomer having a group containing a vinyl bond and other than the monomer represented by the general formula (15), and examples include (meth)acrylic acid, alkyl (meth)acrylate, hydroxyalkyl (meth)acrylate, aromatic ring-containing (meth)acrylate, fatty acid vinyl ester, (meth)acrylamide, styrene or its derivatives, and one or more of these can be used. Among these, (meth)acrylic monomers such as (meth)acrylic acid, alkyl (meth)acrylate, hydroxyalkyl (meth)acrylate, and aromatic ring-containing (meth)acrylate are preferred from the viewpoint of versatility.

[0078] The content of repeating units derived from the monomer represented by the general formula (15) in the vinyl polymer is preferably 0.1% by mass or more, more preferably 10% by mass or more, and even more preferably 20% by mass or more, relative to the total repeating units in the vinyl polymer, from the viewpoint of controlling the shape of the skin. The upper limit is 100% by mass.

[0079] The vinyl polymer is more preferably an acrylic polymer. That is, a preferred silicone dendrimer is an acrylic polymer having a siloxane dendrimer structure in its side chain (hereinafter also referred to as "acrylic silicone dendrimer"). The acrylic silicone dendrimer is a polymer having repeating units derived from a monomer in the general formula (15) in which Y is a (meth)acroyl group, and may further contain repeating units derived from (meth)acrylic monomers other than the monomer represented by general formula (15).

[0080] Examples of commercially available silicone dendrimers include acrylic silicone dendrimers such as "FA 4001 CM Silicone Acrylate" (a cyclopentasiloxane solution of acrylate-polytrimethylsiloxymethacrylate copolymer) and "FA 4002 ID Silicone Acrylate" (an isododecane solution of acrylate-polytrimethylsiloxymethacrylate copolymer) manufactured by Toray Dow Corning.

[0081] As for the silicone polymer, from the viewpoint of shrinkage, control of skin shape, and effect of improving skin wrinkles, one or more selected from the group consisting of silicone-modified polynorbornene, silicone-modified pullulan, trimethylsiloxysilicate, trifluoropropyldimethyl / trimethylsiloxysilicate, and acrylic silicone dendrimers are preferred, one or more selected from the group consisting of silicone-modified polynorbornene, silicone-modified pullulan, trimethylsiloxysilicate, and trifluoropropyldimethyl / trimethylsiloxysilicate are more preferred, and from the viewpoint of skin shrinkage, one or more selected from the group consisting of silicone-modified polynorbornene and silicone-modified pullulan are even more preferred, and silicone-modified polynorbornene is even more preferred.

[0082] As for the polymer of component (A), a silicone polymer having a silicone structure is preferred from the viewpoint of shrinkage, control of skin shape, and effect of improving skin wrinkles, more preferably one or more selected from silicone-modified polynorbornene and silicone-modified pullulan, and even more preferably silicone-modified polynorbornene.

[0083] Component (A) can be used alone or in combination of two or more types. From the viewpoint of contractility, control of skin shape, and effect on improving skin wrinkles, the content is preferably 0.1% by mass or more in the composition, more preferably 1% by mass or more, even more preferably 4% by mass or more, even more preferably 5% by mass or more, preferably 30% by mass or less, more preferably 25% by mass or less, even more preferably 20% by mass or less, and even more preferably 18% by mass or less. Furthermore, the content of component (A) in the composition is preferably 0.1 to 30% by mass, more preferably 1 to 25% by mass, even more preferably 4 to 20% by mass, and even more preferably 5 to 18% by mass.

[0084] <Ingredient (B)> The component (B) used in this invention is a volatile oil having a volatility of 14% or more after drying for 30 minutes at 1 atmosphere, 40°C, and 60% RH. By including component (B), the drying speed of the composition containing component (A) is improved, which accelerates the shrinkage of component (A) during the drying process, causing the skin to shrink and maintain its shape, thereby further improving the effect of controlling the shape of the skin and improving skin wrinkles. From the viewpoint of obtaining the above effects, the volatilization rate of component (B) after drying at 1 atmosphere, 40°C, and 60% RH for 30 minutes is preferably 18% or more, more preferably 25% or more, even more preferably 30% or more, even more preferably 45% or more, even more preferably 65% ​​or more, even more preferably 80% or more, and even more preferably 95% or more. The upper limit is 100%. The volatilization rate of component (B) is calculated by placing 0.5 g of the sample in a 40 mm diameter glass petri dish, letting it stand at 40°C for 30 minutes under 1 atmosphere and 60% RH conditions to dry. The sample mass before drying is W0 (g), and the sample mass after drying is W1 (g). The value is calculated as {(W0-W1) / W0} × 100. A larger value indicates a faster volatilization rate and easier drying. Furthermore, two or more volatile oils may be used as component (B). The above volatility can be measured specifically by the method described in the examples.

[0085] Component (B) is an oil selected from hydrocarbon oils and silicone oils, with a volatility within the above range, from the viewpoint of shrinkage, control of skin shape, and improvement of skin wrinkles. Among these, one or more selected from the group consisting of isododecane (volatility 33%), hexamethyldisiloxane (volatility 100%), methyltrimethicone, and dimethylpolysiloxane with a kinematic viscosity of 2 cSt or less at 25°C is preferred. The kinematic viscosity can be measured, for example, using an Ubbelohde viscometer. From the viewpoint of contractility, controlling skin shape, and enhancing the effect of improving skin wrinkles, component (B) is more preferably one or more selected from the group consisting of isododecane, hexamethyldisiloxane, and dimethylpolysiloxane having a kinematic viscosity of 1.5 cSt or less at 25°C, even more preferably one or more selected from the group consisting of hexamethyldisiloxane and dimethylpolysiloxane having a kinematic viscosity of 1 cSt or less at 25°C, and even more preferably hexamethyldisiloxane.

[0086] Commercially available hexamethyldisiloxane and dimethylpolysiloxane with a kinematic viscosity of 2 cSt or less at 25°C include "KF-96L-0.65cs" (hexamethyldisiloxane), "TMF1.5", "KF-96L-1cs" (octamethyltrisiloxane), "KF-96L-1.5cs", and "KF-96L-2cs" from Shin-Etsu Chemical Co., Ltd., "SH200C Fluid 1cs" and "SH200C Fluid 1.5cs" from Toray Dow Corning, "TSF451-0.65" from Momentive Performance Materials Japan LLC, and "BELSIL DM0.65" from Asahi Kasei Wacker Silicone Co., Ltd.

[0087] Component (B) can be used in combination of one or more types, and its content is preferably 1% by mass or more in the composition, more preferably 30% by mass or more, even more preferably 50% by mass or more, even more preferably 70% by mass or more, even more preferably 75% by mass or more, preferably 99% by mass or less, even more preferably 98% by mass or less, even more preferably 97% by mass or less, even more preferably 95% by mass or less, and even more preferably 87% by mass or less. Furthermore, the content of component (B) is preferably 1 to 99% by mass in the composition, more preferably 30 to 98% by mass, even more preferably 50 to 97% by mass, even more preferably 70 to 95% by mass, and even more preferably 75 to 87% by mass.

[0088] In the present invention, the mass ratio (A) / (B) of component (A) to component (B) is preferably 0.02 or higher, more preferably 0.03 or higher, even more preferably 0.04 or higher, even more preferably 0.05 or higher, even more preferably 0.1 or higher, preferably 1 or lower, more preferably 0.7 or lower, even more preferably 0.4 or lower, and even more preferably 0.25 or lower. Furthermore, the mass ratio (A) / (B) of component (A) to component (B) is preferably 0.02 to 1, more preferably 0.03 to 0.7, even more preferably 0.04 to 0.4, even more preferably 0.05 to 0.25, and even more preferably 0.1 to 0.25.

[0089] <Other ingredients> The composition used in the present invention may further contain ingredients commonly used in cosmetics, in addition to the above-mentioned components. Examples of such ingredients include non-volatile oils, surfactants, water-soluble polymers, antioxidants, UV absorbers, vitamins, preservatives, pH adjusters, fragrances, plant extracts, humectants, colorants, cooling agents, antiperspirants, bactericides, and skin activators. Furthermore, since the composition can achieve wrinkle-improving effects even without containing wrinkle-improving ingredients, it is not necessary to include wrinkle-improving ingredients.

[0090] The composition used in the present invention can be produced by conventional methods, for example, by mixing components (A) and (B).

[0091] In the present invention, the steps of applying the composition obtained in this manner to a target area of ​​skin multiple times locally for a period of 7 days or more, with a cumulative application time of 28 hours or more over 7 days, and removing the composition after each application are repeated. The application period is 7 days or longer, preferably 14 days or longer, and more preferably 28 days or longer. The cumulative application time over 7 days should be 28 hours or more, preferably 35 hours or more, and more preferably 42 hours or more. The application time for a single treatment is preferably 4 hours or more, more preferably 5 hours or more, and even more preferably 6 hours or more. Furthermore, it is preferable to apply it at least once a day for at least four hours a day for a period of seven days or more.

[0092] The composition is applied topically to the area of ​​skin to be treated. The application method involves applying the composition with a finger or tool to cover the target area. For example, when targeting nasolabial folds, the composition can be applied to the area including the nasolabial folds, including the cheeks and the area below the nose, using a finger or tool, parallel to the folds. The amount of composition to be applied in one application should be 0.02 to 0.5 mg / mm², from the perspective of improving elasticity, controlling skin shape, and enhancing the wrinkle-reducing effect on the skin. 2 Preferably, the concentration is 0.05 to 0.15 mg / mm³. 2 This is preferable. You may apply a commonly used toner before applying the composition. Furthermore, it is possible to apply a conventional cosmetic after applying the composition of the present invention.

[0093] After application, preferably after 4 hours or more, the composition is removed. The removal step is preferably a skin cleansing step, and any method that can wash away or peel off the applied composition is acceptable. For example, it can be removed by washing with a skin cleanser, facial cleanser, makeup remover, etc. For example, the method of the present invention can be carried out by repeatedly applying the composition before going to bed and removing the composition after waking up. Furthermore, when the composition used in this invention is removed from the skin, only the non-volatile components remain, as the volatile components evaporate after application. Therefore, the composition differs from that at the time of application.

[0094] In this way, by repeating the steps of applying the composition locally multiple times and removing the composition after each application, it is possible to fundamentally control the shape of the skin even after the composition has been removed. For example, it can improve wrinkles and sagging skin, such as making nasolabial folds (smile lines), crow's feet, forehead wrinkles, and frown lines less noticeable, and improving sagging cheeks and jawline. Furthermore, the method of this invention is performed for cosmetic purposes. [Examples]

[0095] The present invention will be described below with reference to examples, but the present invention is not limited to the scope of these examples. In these examples, various measurements and evaluations were performed by the following methods.

[0096] (Number average molecular weight Mn) The number-average molecular weight of the polymer was measured by gel filtration chromatography (GPC) using polystyrene as the standard substance under the following conditions. Measuring device: HLC-8320GPC (manufactured by Tosoh Corporation) Columns: K-806L (Shodex), 2 in series Detector: RI Eluent: 1 mmol / L-Farmin DM20 (manufactured by Kao Corporation) / CHCl3 Flow rate: 1.0mL / min Column temperature: 40℃

[0097] (Deformation ratio) A 10% by mass hexamethyldisiloxane solution of the polymer of component (A) used in each composition was prepared. 0.005 g of this solution was applied to one side of a polyethylene sheet 1 (LL Film, manufactured by Enshu Chemical Industries Co., Ltd.) measuring 20 mm wide (W) × 100 mm long (L0) × 0.03 mm thick, as shown in Figure 1(a), in a 20 mm wide × 50 mm long area (part 2 shown in Figure 1(a)) extending from one end 1a of the short side of the polyethylene sheet 1 in the longitudinal direction, and dried in a constant temperature bath set to 40°C for 10 minutes. In the dried polyethylene sheet (Figure 1(b)), the length of the polyethylene sheet in the area where the solution was applied was defined as L1 (50 mm), and the length of the polyethylene sheet in the area that was deformed (curled) due to shrinkage after drying was defined as L2. L2 / L1 was calculated and this value was taken as the polymer deformation ratio. L2 was the average value of the values ​​measured on the two long sides of the polyethylene sheet 1.

[0098] (Volatility) A 0.5g sample was placed in a 40mm diameter glass petri dish and dried by standing it on a hot plate set to 40°C for 30 minutes under 1 atmosphere and 60% RH conditions. The sample mass before drying was denoted as W0 (g), and the sample mass after drying was denoted as W1 (g). The volatilization rate (%) was calculated as {(W0-W1) / W0} × 100. A higher value indicates a faster volatilization rate and easier drying.

[0099] Example 1 Compositions with the compositions shown in Table 1 were prepared by conventional methods. Apply the lotion to your entire face, then apply the composition shown in Table 1 to the nasolabial fold area (15 cm). 2 Within the range of 150 mg (0.1 mg / mm³) 2 The product was applied, left to dry for 6 hours, and then washed off with a facial cleanser. This process was repeated daily, and the improvement in the appearance of nasolabial folds, skin radiance, skin firmness, a feeling of tightness around the mouth, and skin transparency were evaluated. The results are shown in Tables 2 and 3.

[0100] (Improvement of the appearance of nasolabial folds, skin radiance, skin firmness, a more defined look around the mouth, and skin clarity) Three expert panelists conducted a sensory evaluation of the skin after the removal of the composition, assessing improvement in the appearance of nasolabial folds, skin luster, skin firmness, a clean feeling around the mouth, and skin transparency, using untreated skin as a baseline. The results are shown in the total scores of the three panelists. 0; No change. 1; Slightly improved (slightly better). 2; It improved (became better).

[0101] [Table 1]

[0102] *1: Isododecane solution of norbornene / tris(trimethylsiloxy)silylnorbornene) copolymer manufactured by Shin-Etsu Chemical Co., Ltd. (e / f = 60 / 40 (mol / mol), Mn = 360,000 in formula (6) below, effective concentration: 30% by mass)

[0103] [ka]

[0104] [Table 2]

[0105] [Table 3]

[0106] Example 2 Apply the lotion to your entire face, then apply the composition shown in Table 1 to the nasolabial fold area (15 cm). 2 Within the range of 150 mg (0.1 mg / mm³) 2 The product was applied and left on for at least 4 hours once a day, before going to bed, and then washed off with a facial cleanser. 39 healthy women aged 40-65 repeated this process daily for 2 months. The number of days of continuous use and the number of participants who began to notice a reduction in the appearance of nasolabial folds are shown in Table 4. The results are shown in Table 4.

[0107] [Table 4]

[0108] Example 3 This study involved 14 healthy men in their 40s and 50s with visible nasolabial folds. After applying lotion to their entire face, they applied the compositions shown in Table 1 to one side of the nasolabial fold area (15 cm). 2 Within the range of 150 mg (0.1 mg / mm³) 2 The product was applied to one side (the other side was left untreated), and applied once a day for at least 4 hours before going to bed. After application, it was left on and then washed off with a facial cleanser. This process was repeated daily for 8 weeks, after which use was discontinued for 1 week. The depth of the nasolabial folds was measured using the following method before continuous use, at 8 weeks of continuous use, and after the 1-week discontinuation. The results are shown in Figures 3 and 4.

[0109] (Method for measuring the depth of nasolabial folds) Fourteen subjects washed their faces with a facial cleanser, applied lotion, and then acclimatized to a 20°C, 50% RH environment for 15 minutes before measurement. Measurements were taken using a skin analyzer (ANTERA 3D, miravex Inc.), capturing three 5cm square images of the nasolabial folds on both sides (treated and untreated sides), as shown in Figure 2. Wrinkle depth was determined by image analysis using a dedicated software wrinkle analysis filter. The results are shown as the average values ​​for the 14 subjects.

[0110] As shown in Figure 3, continuous use for 8 weeks resulted in shallower nasolabial folds compared to the untreated area. Furthermore, as shown in Figure 4, even one week after discontinuing continuous use, the nasolabial folds were shallower compared to the untreated area, indicating that the effect was sustained.

[0111] Example 4 (Effect of improving nasolabial folds) This study involved 14 healthy men in their 40s and 50s with visible nasolabial folds. After applying lotion to their entire face, they applied the compositions shown in Table 1 to one side of the nasolabial fold area (15 cm). 2 Within the range of 150 mg (0.1 mg / mm³) 2The skin was treated on one side and left untreated on the other. The treatment was performed once a day for at least 4 hours, at bedtime, and then washed off with a facial cleanser. This continued for 8 weeks. Skin measurements were taken before application and 8 weeks after application. After washing their faces with a commercially available facial cleanser, participants entered the measurement room (room temperature 20°C, humidity 50%RH) and acclimatized for 15 minutes. Then, replicas were taken and changes in nasolabial folds were measured. Additionally, a questionnaire was conducted only 8 weeks after application.

[0112] (1) Three-dimensional analysis of nasolabial folds (change in Ra): While seated with eyes lightly closed, a replica agent (GC EXAFINE, manufactured by GC Corporation) was applied to each nasolabial fold. After a certain period of time, the hardened replica agent was peeled off, and skin replicas were collected. The collected replicas were analyzed for Ra (arithmetic mean roughness, μm) using PRIMOS (GF Messetechnik GmbH), and the change in Ra was determined. The average of 14 subjects was calculated, and the results are shown in Figure 5.

[0113] (2) Questionnaire on nasolabial folds: While the subjects checked their nasolabial folds in a mirror, they evaluated the length of the wrinkles, the depth of the wrinkles, and the perceived change in wrinkle visibility on both the treated and untreated sides, using the following 7-point scale. The average of 14 subjects was calculated, and the results are shown in Figures 6 to 8.

[0114] <Changes in wrinkle length> 1: I feel it's become much shorter. 2: I feel it's become shorter. 3: I feel it's a little shorter. 4: I can't say either way. 5: I feel it's become a bit too long. 6. I feel it's become too long. 7: I feel it has become very long.

[0115] <Changes in wrinkle depth> 1: I feel it has become very shallow. 2: I feel it has become shallower. 3: I feel it's become slightly shallower. 4: I can't say either way. 5: I feel it's become slightly deeper. 6: I feel it has deepened. 7: I feel it has become much deeper.

[0116] <Changes in the appearance of wrinkles> 1: I feel it has improved significantly. 2: I feel it has improved. 3: I feel it has improved somewhat. 4: I can't say either way. 5: I feel it has gotten slightly worse. 6. I feel it has gotten worse. 7: I feel it has gotten much worse.

[0117] As shown in Figure 5, the change in Ra (8 weeks - 0 weeks) showed a significant improvement on the side with the composition applied compared to the uncoated side. Furthermore, as shown in Figures 6 to 8, the length and depth of wrinkles showed a significant improvement on the side with the composition applied compared to the uncoated side, and an improvement trend was observed in the visibility of wrinkles.

[0118] Example 5 (Effect of improving crow's feet wrinkles) Nine healthy men in their 40s and 50s with wrinkles around their eyes were included in the study. After applying lotion to their entire face, the compositions shown in Table 1 were applied to one side of the outer corner of the eye, leaving the other side untreated. Each application covered approximately 1.5 cm from the outer corner of one eye, about 1 cm away from the outer corner. 2 15 mg (0.1 mg / mm³) within the range 2 The product was applied once a day for at least 4 hours, left on while sleeping, then washed off with a facial cleanser, and continued for 8 weeks. Skin measurements were taken before application and 8 weeks after application. After washing the face with a commercially available facial cleanser, participants entered the measurement room (room temperature 20°C, humidity 50%RH) and acclimatized for 15 minutes. Then, replicas of the outer corners of both eyes were taken in the same manner as in Example 4. The collected replicas were analyzed for Ra: arithmetic mean roughness (μm) using PRIMOS (GF Messetechnik GmbH) to determine the change in Ra. The average values ​​for 9 participants were calculated and the results are shown in Figure 9. As shown in Figure 9, the change in Ra (8 weeks - 0 weeks) showed an improvement trend on the side with the composition applied compared to the side without the coating.

[0119] Example 6 (Effect of improving forehead wrinkles) Seven healthy men in their 40s and 50s with visible forehead wrinkles were included in this study. After applying lotion to their entire face, the compositions shown in Table 1 were applied to one side of the forehead, leaving a gap of approximately 10 mm in the center of the wrinkles, while the other side remained untreated. Approximately 3 cm of each side was applied per session. 2 30 mg (0.1 mg / mm³) within the range 2 The product was applied once a day for at least 4 hours, left on while sleeping, then washed off with a facial cleanser, and continued for 8 weeks. Skin measurements were taken before application and 8 weeks after application. After washing the face with a commercially available facial cleanser, participants entered the measurement room (room temperature 20°C, humidity 50%RH) and acclimatized for 15 minutes. Then, a replica of the forehead was taken in the same manner as in Example 4. The collected replicas were analyzed separately for the left and right sides using PRIMOS (GF Messetechnik GmbH) to determine the change in Ra (arithmetic mean roughness (μm)). The average values ​​for 7 participants were calculated and the results are shown in Figure 10. As shown in Figure 10, the change in Ra (8 weeks - 0 weeks) showed an improvement trend in the side with the composition applied compared to the side without the coating.

[0120] Example 7 (Effect of improving frown lines) Five healthy men in their 40s and 50s with frown lines were included in the study. After applying lotion to their entire face, the compositions shown in Table 1 were applied to one side of the frown line, leaving the other side untreated. Approximately 2 cm of each side was treated per application. 2 20 mg (0.1 mg / mm³) within the range 2 The product was applied once a day for at least 4 hours, left on while sleeping, then washed off with a facial cleanser, and continued for 8 weeks. Skin measurements were taken before application and 8 weeks after application. After washing the face with a commercially available facial cleanser, participants entered the measurement room (room temperature 20°C, humidity 50%RH) and acclimatized for 15 minutes. Then, replicas of the glabella were taken in the same manner as in Example 4. The collected replicas were analyzed separately for the left and right sides using PRIMOS (GF Messetechnik GmbH) to determine the change in Ra: arithmetic mean roughness (μm). The average values ​​for 5 participants were calculated and the results are shown in Figure 11. As shown in Figure 11, the change in Ra (8 weeks - 0 weeks) showed an improvement trend on the side with the composition applied compared to the side without the coating.

[0121] Example 8 (Effect of improving sagging cheeks) This study involved 14 healthy men in their 40s and 50s with noticeable sagging cheeks. After applying lotion to their entire face, they applied the compositions shown in Table 1 to one side of the nasolabial fold area (15 cm). 2 Within the range of 150 mg (0.1 mg / mm³) 2 The skin was treated on one side and left untreated on the other. The treatment was performed once a day for at least 4 hours, at bedtime, and then washed off with a facial cleanser. This continued for 8 weeks. Skin measurements were taken before application and 8 weeks after application. After washing their faces with a commercially available facial cleanser, participants entered the measurement room (room temperature 20°C, humidity 50%RH) and acclimatized for 15 minutes. Then, full-face photographs were taken from 45-degree angles to the left and right using VISIA-CR (Canfield Scientific). For cheek sagging in the test area, a visual evaluation was performed by one expert evaluator using the cheek sagging evaluation criteria (Tsukahara K, Takema Y, Fujimura T, Moriwaki S, Kitahara T, Imokawa G. Determination of age-related changes in the morphological structure (sagging) of the human cheek using a photonumeric scale and three-dimensional surface parameters. Int J Cosmet Sci 2000; 22: 247-258.). The average score obtained from 14 participants was calculated, and the results are shown in Figure 12. As shown in Figure 12, compared to the untreated side, an improvement in cheek sagging was observed on the side where the composition was applied.

[0122] Example 9 The compositions shown in Table 5 were prepared. When these compositions are repeatedly applied to the nasolabial folds in the same manner as in Example 1, the appearance of the nasolabial folds is improved after the composition is removed, and the skin's luster, firmness, the feeling around the mouth is refreshed, and the skin's transparency is also good.

[0123] [Table 5] [Explanation of Symbols]

[0124] 1 Polyethylene sheet 1a One end of the short side of polyethylene sheet 1 2. Area to which the polymer solution was applied.

Claims

1. A method for controlling the shape of the skin after removal of the composition, comprising repeating the steps of: topically applying a composition containing the following components (A) and (B) to a target area of ​​skin multiple times for a period of 7 days or more such that the cumulative application time over the 7 days is 28 hours or more; and removing the composition after each application. (A) a polymer having a deformation ratio of 0.3 or more and 1 or less, as measured by the following method (1); Method (1): A 10% by weight solution of the polymer in hexamethyldisiloxane is prepared. 0.005 g of the solution is applied to one side of a polyethylene sheet measuring 20 mm wide x 100 mm long x 0.03 mm thick in an area measuring 20 mm wide x 50 mm long from one end of the short side in the longitudinal direction, and the sheet is dried for 10 minutes in a thermostatic chamber set to 40°C. The length of the portion of the polyethylene sheet where the solution was applied was designated as L1, and the length of the portion of the polyethylene sheet which had been deformed due to shrinkage after drying was designated as L2, and the value of L2 / L1 was designated as the deformation ratio. (B) A volatile oil having a volatilization rate of 14% or more after drying for 30 minutes at 40°C and 60% R.H. under 1 atmosphere.

2. 2. The method for controlling the shape of the skin according to claim 1, wherein the polymer of component (A) is a polymer having a silicone structure.

3. 3. The method for controlling the shape of the skin according to claim 1 or 2, wherein component (B) is one or more oils selected from the group consisting of hydrocarbon oils and silicone oils.

4. 3. The method for controlling the shape of the skin according to claim 1 or 2, wherein the step of removing the composition is a step of washing the skin.

5. A method for improving wrinkles on the skin after removal of the composition, comprising the steps of: topically applying a composition containing the following components (A) and (B) to a target area of ​​skin multiple times for a period of 7 days or more such that the cumulative application time over the 7 days is 28 hours or more; and repeating the steps of removing the composition after each application. (A) a polymer having a deformation ratio of 0.3 or more and 1 or less, as measured by the following method (1); Method (1): A 10% by weight solution of the polymer in hexamethyldisiloxane is prepared. 0.005 g of the solution is applied to one side of a polyethylene sheet measuring 20 mm wide x 100 mm long x 0.03 mm thick in an area measuring 20 mm wide x 50 mm long from one end of the short side in the longitudinal direction, and the sheet is dried for 10 minutes in a thermostatic chamber set to 40°C. The length of the portion of the polyethylene sheet where the solution was applied was designated as L1, and the length of the portion of the polyethylene sheet which had been deformed due to shrinkage after drying was designated as L2, and the value of L2 / L1 was designated as the deformation ratio. (B) A volatile oil having a volatilization rate of 14% or more after drying for 30 minutes at 40°C and 60% R.H. under 1 atmosphere.

6. A method for controlling the shape of the skin after removal of the composition, comprising the steps of: topically applying a composition containing the following components (A) and (B) to a target area of ​​skin at least once a day for a period of at least 7 days, for at least 4 hours a day; and repeating the steps of removing the composition after each application. (A) a polymer having a deformation ratio of 0.3 or more and 1 or less, as measured by the following method (1); Method (1): A 10% by weight solution of the polymer in hexamethyldisiloxane is prepared. 0.005 g of the solution is applied to one side of a polyethylene sheet measuring 20 mm wide x 100 mm long x 0.03 mm thick in an area measuring 20 mm wide x 50 mm long from one end of the short side in the longitudinal direction, and the sheet is dried for 10 minutes in a thermostatic chamber set to 40°C. The length of the portion of the polyethylene sheet where the solution was applied was designated as L1, and the length of the portion of the polyethylene sheet which had been deformed due to shrinkage after drying was designated as L2, and the value of L2 / L1 was designated as the deformation ratio. (B) A volatile oil having a volatilization rate of 14% or more after drying for 30 minutes at 40°C and 60% R.H. under 1 atmosphere.

Images