Hair cosmetic

Abstract

To repair the cuticle CMC of hair and enhance hair strength, while also reducing the drying time of shampooed hair and minimizing damage from extended hair wetness and damage from dryer heat.SOLUTION: Hair cosmetics comprise at least one lipid peptide compound composed of low molecular weight lipid peptide or its pharmaceutically acceptable salt. Applying the hair cosmetics to hair enables a reduction in hair drying time and an increase in tensile strength.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to a hair cosmetic that repairs the cuticle CMC (lipid-cell membrane complex) of hair, and more specifically, to a hair cosmetic that contains at least one lipid peptide-type compound, thereby shortening the drying time of washed hair and improving the tensile strength of hair. [Background technology]

[0002] Hair is damaged by the living environment (ultraviolet rays and heat from sunlight), daily hair care habits (friction from washing and brushing), and chemical treatments (coloring, perms, etc.).

[0003] The cuticle is the outermost tissue of the hair, and originally serves the role of protecting the hair, preventing the loss of nutrients and moisture from the inside of the hair, but in damaged hair, the cuticle is damaged, and the cuticle's original function is reduced. A damaged cuticle has countless small cavities, and absorbs a lot of moisture like a sponge, so it takes time to evaporate the moisture and dry the hair.

[0004] It is known that hair consists of three structures: the central part called the medulla, the middle part called the cortex that surrounds it, and the outermost part called the cuticle. It is said that the cause of damage is the cuticle CMC (lipid-cell membrane complex), which acts as an adhesive between the cuticles located at the outermost part, becoming spongy. If the repairing ingredients can be retained, it is expected that damage can be suppressed, and further effects can be expected with repeated use.

[0005] Various hair cosmetics targeting the cuticle have been reported, but only hair protection cosmetics intended to restore hair cuticles damaged by chlorine in swimming pools and tap water and prevent the hair from becoming dry and stiff (Patent Document 1) and a water-dispersible biocellulose fine fiber network dispersion have been found to have the effect of not damaging the cuticle on the surface of the keratin structure (Patent Document 2). However, there is no effect of shortening the drying time of washed hair or improving the tensile strength of hair by repairing the cuticle CMC.

[0006] Meanwhile, the present inventors have found that a hair cosmetic containing at least one type of lipid peptide compound consisting of a low molecular weight lipid peptide or a pharma- ceutical usable salt thereof forms a film on the hair surface and promotes the penetration of active ingredients into the hair (Patent Document 3). However, there is still room for improvement in this hair cosmetic with respect to the drying speed and tensile strength of the hair. The present invention relates to a hair cosmetic composition that, when applied to hair, can repair the cuticle CMC, thereby improving the drying speed of treated hair and imparting smoothness to the hair during rinsing. It also relates to a hair cosmetic composition that can improve the tensile strength of hair. [Prior art documents] [Patent documents]

[0007] [Patent Document 1] Patent Publication No. 2001-19622 [Patent Document 2] Special table 2019-507162 [Patent Document 3] International Publication Pamphlet WO2020 / 004649 Summary of the Invention [Problem to be solved by the invention]

[0008] The above-mentioned technologies related to the cuticle all suppress damage to the cuticle or This is a technology for repairing damaged cuticles, and does not improve the drying speed of treated hair by repairing the cuticle CMC. Therefore, there has been a strong demand for hair cosmetics that can repair damage to hair by retaining the hair cosmetics in the cuticle CMC layer.

[0009] To provide a hair cosmetic composition which not only improves the tensile strength of hair but also shortens the time required for drying hair after washing, and prevents damage to hair caused by moisture after washing and damage caused by the heat of a hair dryer. [Means for solving the problem]

[0010] As a result of intensive research conducted by the present inventors to solve the above problems, they discovered that by incorporating at least one type of lipid peptide-type compound into a hair cosmetic composition, the lipid peptide penetrates the cuticle CMC and remains in the cuticle layer of the hair, thereby not only improving the tensile strength of the hair but also shortening the drying time of the hair after washing, and thus completed the present invention.

[0011] That is, a first aspect of the present invention is a hair cosmetic comprising at least one lipid peptide type compound consisting of a low molecular weight lipid peptide or a pharma- ceutical usable salt thereof. As a second aspect, the present invention provides a hair cosmetic composition according to the first aspect, in which the lipid peptide type compound is a compound in which a lipid portion consisting of an aliphatic group having 9 to 23 carbon atoms is bonded to a peptide portion having a repeating amino acid bond structure. As a third aspect, the present invention provides a hair cosmetic composition according to the second aspect, characterized in that the lipid peptide type compound comprises at least one of compounds represented by the following formulas (1) to (3) or pharma- ceutical acceptable salts thereof: [ka] (In the formula, R 1 represents an aliphatic group having 9 to 23 carbon atoms; R 2represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, which may have a branched chain having 1 or 2 carbon atoms; R 3 Ha-(CH2) n represents an -X group, n is a number from 1 to 4, and X represents an amino group, a guanidino group, a -CONH2 group, or a 5-membered or 6-membered ring or a fused heterocycle composed of a 5-membered ring and a 6-membered ring, which may have 1 to 3 nitrogen atoms. [ka] (In the formula, R 4 represents an aliphatic group having 9 to 23 carbon atoms; R 5 ~R 7 each independently represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms which may have a branched chain having 1 or 2 carbon atoms, or -(CH) n represents an -X group, n is a number from 1 to 4, and X represents an amino group, a guanidino group, a -CONH2 group, or a 5-membered or 6-membered ring or a fused heterocycle composed of a 5-membered ring and a 6-membered ring, which may have 1 to 3 nitrogen atoms. [ka] (In the formula, R 8 represents an aliphatic group having 9 to 23 carbon atoms; R 9 ~R 12 each independently represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms which may have a branched chain having 1 or 2 carbon atoms, or -(CH) n represents an -X group, n is a number from 1 to 4, and X represents an amino group, a guanidino group, a -CONH2 group, or a 5-membered or 6-membered ring or a fused heterocycle composed of a 5-membered ring and a 6-membered ring, which may have 1 to 3 nitrogen atoms. According to a fourth aspect, the present invention provides a hair cosmetic composition for repairing cuticle CMC of hair, comprising the hair cosmetic composition according to any one of the first to third aspects. A fifth aspect of the present invention is a method for repairing hair cuticle CMC, the method comprising applying the hair cosmetic composition according to any one of the first to third aspects to hair. According to a sixth aspect, the present invention provides a hair cosmetic composition for shortening a hair drying time, the hair cosmetic composition comprising the hair cosmetic composition according to any one of the first to third aspects. According to a seventh aspect, the present invention provides a method for shortening a time required for drying hair, the method comprising applying the hair cosmetic composition according to any one of the first to third aspects to hair. According to an eighth aspect, the present invention provides a hair cosmetic composition for increasing tensile strength of hair, comprising the hair cosmetic composition according to any one of the first to third aspects. A ninth aspect of the present invention is a method for increasing tensile strength of hair, the method comprising applying the hair cosmetic composition according to any one of the first to third aspects to hair. Effect of the Invention

[0012] According to the present invention, by containing at least one kind of lipid peptide type compound, it is possible to provide a hair cosmetic composition which not only improves the tensile strength of hair but also shortens the drying time of hair after washing, thereby preventing damage caused by moisture after washing and damage caused by heat of a hair dryer. [Brief description of the drawings]

[0013] [Figure 1] FIG. 1 is a graph showing the results of a tensile strength test on bleached hair treated with the conditioners of Comparative Example 1 and Example 1. [Diagram 2] FIG. 2 is a graph showing the drying time using a hair dryer when bleached hair treated with the conditioners of Comparative Example 2 and Example 2 was washed. [Diagram 3] FIG. 3 is a graph showing the drying time using a hair dryer when bleached hair treated with the conditioners of Comparative Example 2 and Example 3 was washed. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0014] The present invention provides a hair cosmetic that repairs the hair cuticle CMC (lipid-cell membrane complex) by containing at least one lipid peptide type compound consisting of a low molecular weight lipid peptide or a pharma- ceutical acceptable salt thereof, thereby shortening the drying time of washed hair and improving the tensile strength of hair.

[0015] The above-mentioned lipid peptide type compound is preferably a compound in which a peptide portion having a repeating amino acid bond structure is bound to a lipid portion consisting of an aliphatic group having 9 to 23 carbon atoms.

[0016] Furthermore, the above-mentioned lipid peptide type compound is more preferably composed of at least one of the compounds (lipid peptides) represented by the following formulas (1) to (3) or pharma- ceutical salts thereof (low molecular weight compounds having a lipid portion as a hydrophobic site and a peptide portion as a hydrophilic site). [ka]

[0017] In the above formula (1), R 1 represents an aliphatic group having 9 to 23 carbon atoms; R 1 is preferably a linear aliphatic group having 11 to 23 carbon atoms which may have 0 to 2 unsaturated bonds. R 1 Specific examples of the lipid portion (acyl group) composed of an acyl group adjacent to the carbonyl group include a lauroyl group, a dodecylcarbonyl group, a myristoyl group, a tetradecylcarbonyl group, a palmitoyl group, a margalloyl group, an oleoyl group, an elaidoyl group, a linoleoyl group, a stearoyl group, a vaccenoyl group, an octadecylcarbonyl group, an arachidoyl group, an eicosylcarbonyl group, a behenoyl group, an elcanoyl group, a docosylcarbonyl group, a lignoceyl group, and a nervoyl group. Particularly preferred are a lauroyl group, a myristoyl group, a palmitoyl group, a margalloyl group, a stearoyl group, an oleoyl group, an elaidoyl group, and a behenoyl group.

[0018] In the above formula (1), R 2 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms which may have a branched chain having 1 or 2 carbon atoms. The above-mentioned alkyl group having 1 to 4 carbon atoms, which may have a branched chain having 1 or 2 carbon atoms, means an alkyl group having 1 to 4 carbon atoms in the main chain and which may have a branched chain having 1 or 2 carbon atoms, and specific examples thereof include a methyl group, an ethyl group, an n-propyl group, an i-propyl group, an n-butyl group, an i-butyl group, a sec-butyl group, and a tert-butyl group.

[0019] Above R 2 is preferably a hydrogen atom or an alkyl group having 1 to 3 carbon atoms which may have a branched chain and has 1 carbon atom, and more preferably a hydrogen atom. An alkyl group having 1 to 3 carbon atoms and which may have a branched chain having 1 carbon atom means an alkyl group having 1 to 3 carbon atoms in the main chain and which may have a branched chain having 1 carbon atom. Specific examples thereof include a methyl group, an ethyl group, an n-propyl group, an i-propyl group, an i-butyl group, and a sec-butyl group, and preferably a methyl group, an i-propyl group, an i-butyl group, or a sec-butyl group.

[0020] In the above formula (1), R 3 represents a -(CH2)nX group. In the group, n represents a number from 1 to 4, and X represents an amino group, a guanidino group, a -CONH2 group, a 5-membered or 6-membered ring which may have 1 to 3 nitrogen atoms, or a fused heterocycle composed of a 5-membered ring and a 6-membered ring. Above R 3 In the -(CH2)nX group, X is preferably an amino group, a guanidino group, a carbamoyl group (-CONH2 group), a pyrrole group, an imidazole group, a pyrazole group or an indole group, more preferably an imidazole group. In the -(CH2)nX group, n is preferably 1 or 2, more preferably 1. Therefore, the above-mentioned -(CH2)n- group preferably represents an aminomethyl group, a 2-aminoethyl group, a 3-aminopropyl group, a 4-aminobutyl group, a carbamoylmethyl group, a 2-carbamoylethyl group, a 3-carbamoylbutyl group, a 2-guanidinoethyl group, a 3-guanidinobutyl group, a pyrrolemethyl group, a 4-imidazolemethyl group, a pyrazolemethyl group, or a 3-indolemethyl group, more preferably a 4-aminobutyl group, a carbamoylmethyl group, a 2-carbamoylethyl group, a 3-guanidinobutyl group, a 4-imidazolemethyl group, or a 3-indolemethyl group, and even more preferably a 4-imidazolemethyl group.

[0021] In the compound represented by the above formula (1), a lipid peptide that is particularly suitable as a lipid peptide type compound is a compound formed from the following lipid portion and peptide portion (amino acid assembly portion). In this specification, the abbreviations of amino acids are alanine (Ala), asparagine (Asn), glutamine (Gln), glycine (Gly), histidine (His), isoleucine (Ile), leucine (Leu), lysine (Lys), tryptophan (Trp), and valine (Val). Lauroyl-Gly-His, Lauroyl-Gly-Gln, Lauroyl-Gly-Asn, Lauroyl-Gly-Trp, Lauroyl-Gly-Lys, Lauroyl-Ala-His, Lauroyl-Ala-Gln, Lauroyl-Ala-Asn, Lauroyl-Ala-Trp, Lauroyl-Ala-Lys; Myristoyl-Gly-His, Myristoyl-Gly-Gln, Myristoyl-Gly-Asn, Myristoyl-Gly-Trp, Myristoyl-Gly-Lys, Myristoyl-Ala-His, Myristoyl-Ala-Gln, Myristoyl-Ala-Asn, Myristoyl-Ala-Trp, Myristoyl-Ala-Lys; Palmitoyl Stearoyl-Gly-His, Palmitoyl-Gly-Gln, Palmitoyl-Gly-Asn, Palmitoyl-Gly-Trp, Palmitoyl-Gly-Lys, Palmitoyl-Ala-His, Palmitoyl-Ala-Gln, Palmitoyl-Ala-Asn, Palmitoyl-Ala-Trp, Palmitoyl-Ala-Lys; Stearoyl-Gly-His, Stearoyl-Gly-Gln, Stearoyl-Gly-Asn, Stearoyl-Gly-Trp, Stearoyl-Gly-Lys, Stearoyl-Ala-His, Stearoyl-Ala-Gln, Stearoyl-Ala-Asn, Stearoyl-Ala-Trp, Stearoyl-Ala-Lys.

[0022] Most preferred are lauroyl-Gly-His, lauroyl-Ala-His; myristoyl-Gly-His, myristoyl-Ala-His; palmitoyl-Gly-His, palmitoyl-Ala-His; stearoyl-Gly-His, and stearoyl-Ala-His.

[0023] [ka]

[0024] In the above formula (2), R 4 represents an aliphatic group having 9 to 23 carbon atoms, and preferred examples thereof include the above-mentioned R 1 The groups are the same as those defined above. In the above formula (2), R 5 ~R 7 each independently represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms which may have a branched chain having 1 or 2 carbon atoms, or a -(CH)X group, and R 5 ~R 7 At least one of the above represents a -(CH2)nX group, where n represents a number from 1 to 4, and X represents an amino group, a guanidino group, a -CONH2 group, or a 5- or 6-membered ring that may have 1 to 3 nitrogen atoms, or a condensed heterocycle composed of a 5- and 6-membered ring. 5 ~R 7 Preferred examples of R 2 and R 3 The groups are the same as those defined above.

[0025] In the compound represented by the above formula (2), a suitable lipid peptide is a compound formed from the following lipid portion and peptide portion (amino acid assembly portion). Lauroyl-Gly-Gly-His, Myristoyl-Gly-Gly-His, Myristoyl-Gly-Gly-Gln, Myristoyl-Gly-Gly-Asn, Myristoyl-Gly-Gly-Trp, Myristoyl-Gly-Gly-Lys, Myristoyl-Gly-Ala-His, Myristoyl-Gly-Ala-Gln, Myristoyl-Gly-Ala-Asn, Myristoyl-Gly-Ala-Trp, Myristoyl-Gly-Ala-Lys, Myristoyl-Ala-Gly-His, Myristoyl-Ala-Gly-Gln, Myristoyl-Ala-Gly-Asn, Myristoyl-Ala-Gly-Trp, Myristoyl-Ala-Gly-Lys, Myristoyl-Gly-His-Gly, Myristoyl-His-Gly-Gly, Palmitoyl-Gly-Gly-His, Palmitoyl-Gly-Gly-Gln, Palmitoyl-Gly-Gly-Asn, Palmitoyl-Gly-Gly-Trp, Palmitoyl-Gly-Gly-Lys, Palmitoyl-Gly-Ala-His, Palmitoyl-Gly-Ala-Gln, Palmitoyl-Gly-Ala-Asn, Palmitoyl-Gly-Ala-Trp, Palmitoyl-Gly-Ala-Lys, Palmitoyl-Ala-Gly-His, Palmitoyl-Ala-Gly-Gln, Palmitoyl-Ala-Gly-Asn, Palmitoyl-Ala-Gly-Trp, Palmitoyl-Ala-Gly-Lys, Palmitoyl-Gly-His-Gly, Palmitoyl-His-Gly-Gly, Stearoyl-Gly-Gly-His.

[0026] Of these, most preferred are lauroyl-Gly-Gly-His, myristoyl-Gly-Gly-His, palmitoyl-Gly-Gly-His, palmitoyl-Gly-His-Gly, palmitoyl-His-Gly-Gly and stearoyl-Gly-Gly-His. [ka]

[0027] In the above formula (3), R 8 represents an aliphatic group having 9 to 23 carbon atoms, and preferred examples thereof include the above-mentioned R 1 The groups are the same as those defined above. In the above formula (3), R 9 ~R 12 each independently represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms which may have a branched chain having 1 or 2 carbon atoms, or a -(CH)X group, and R 9 ~R 12 At least one of the above represents a -(CH2)nX group, where n represents a number from 1 to 4, and X represents an amino group, a guanidino group, a -CONH2 group, or a 5- or 6-membered ring that may have 1 to 3 nitrogen atoms, or a condensed heterocycle composed of a 5- and 6-membered ring. 9 ~R 12 Preferred examples of R 2 and R 3 The groups are the same as those defined above.

[0028] Among the compounds represented by the above formula (3), suitable lipid peptide compounds include lauroyl-Gly-Gly-Gly-His, myristoyl-Gly-Gly-Gly-His, palmitoyl-Gly-Gly-Gly-His, palmitoyl-Gly-Gly-His-Gly, palmitoyl-Gly-His-Gly-Gly, palmitoyl-His-Gly-Gly-Gly, stearoyl-Gly-Gly-Gly-His, and the like.

[0029] In the present invention, the content of the lipid peptide type compound is, for example, 0.01 to 30 mass %, preferably 0.02 to 10 mass %, more preferably 0.03 to 5 mass %, relative to the total mass of the hair cosmetic. In the present invention, it is more preferable to use at least one of the compounds (lipopeptides) represented by the above formulas (1) to (3) or pharma- ceutical acceptable salts thereof as the lipid peptide type compound, and these compounds may be used alone or in combination of two or more kinds.

[0030] The hair cosmetic composition of the present invention may contain water, alcohol, polyhydric alcohol or a mixed solution thereof in addition to at least one of the above lipid peptide type compounds.

[0031] Examples of the water include purified water, purified water, hard water, soft water, natural water, deep sea water, electrolytic alkaline ionized water, electrolytic acidic ionized water, ionized water, and cluster water.

[0032] The alcohol is a monohydric alcohol, and examples thereof include alcohols having 1 to 6 carbon atoms that dissolve in water at any ratio, specifically, methanol, ethanol, 2-propanol, i-butanol, etc., as well as higher alcohols, specifically, oleyl alcohol, phenoxy alcohol, etc.

[0033] The polyhydric alcohol is a dihydric or higher alcohol, for example, propylene glycol, 1,3-butanediol, 2-ethyl-1,3-hexanediol, glycerin, isopentyl diol, ethyl hexanediol, erythrulose, ozonated glycerin, caprylyl glycol, glycol, (C15-18) glycol, (C20-30) glycol, etc. Examples of suitable glycerols include glycerin, diethylene glycol, diglycerin, dithiaoctanediol, DPG, thioglycerin, 1,10-decanediol, decylene glycol, triethylene glycol, methylhydroxymethylcyclohexanol, phytantriol, phenoxypropanediol, 1,2-butanediol, 2,3-butanediol, butylethylpropanediol, 1,2-hexanediol, hexylene glycol, pentylene glycol, methylpropanediol, menthanediol, lauryl glycol, and polypropylene glycol.

[0034] In the present invention, when a polyhydric alcohol is contained, the content thereof can be, for example, 1 to 60% by mass, and preferably 1 to 30% by mass, relative to the total mass of the hair cosmetic preparation. In the present invention, when a polyhydric alcohol is contained, the polyhydric alcohol may be used alone or in combination of two or more kinds.

[0035] The hair cosmetic composition of the present invention may further contain a surfactant. As the surfactant, a compound having a hydrophilic part and a hydrophobic part in the molecule, the hydrophilic part having a betaine structure (hereinafter also referred to as a betaine compound), ethylene glycol alkyl ether, polyglycerin fatty acid ester, or polyoxyethylene polyoxypropylene alkyl ether can be preferably used.

[0036] Examples of the betaine compounds that can be used include betaine compounds known as amphoteric surfactants, such as N-alkyl-N,N-dimethyl amino acid betaines such as lauryl dimethyl amino acetate betaine (lauryl betaine); fatty acid amidoalkyl-N,N-dimethyl amino acid betaines such as cocamidopropyl betaine and lauramidopropyl betaine; imidazoline-type betaines such as sodium cocoamphoacetate and sodium lauroamphoacetate; alkyl sulfobetaines such as lauryl hydroxysulfobetaine and alkyl dimethyl taurine; sulfate-type betaines such as alkyl dimethyl aminoethanol sulfate; and phosphate-type betaines such as alkyl dimethyl aminoethanol phosphate. Examples of the betaine compounds include glycerophospholipids such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol, phosphatidylglycerol, diphosphatidylglycerol (cardiolipin), and phosphatidic acid; lysoglycerophospholipids such as lysophosphatidylcholine (lysolecithin), lysophosphatidylethanolamine, lysophosphatidylserine, lysophosphatidylinositol, lysophosphatidylglycerol, and lysophosphatidic acid; sphingophospholipids such as sphingomyelin; and hydrogenated versions of these. These phospholipids may be derived from animals or plants such as soybeans and egg yolks, or may be synthesized by chemical or enzymatic methods. Among the above betaine compounds, preferred are lauryl dimethylaminoacetic acid betaine, lauric acid amidopropyl betaine, lauryl hydroxysulfobetaine, stearyl betaine, lysophosphatidylcholine (lysolecithin), lysophosphatidylethanolamine, lysophosphatidylserine, lysophosphatidylinositol, lysophosphatidylglycerol, lysophosphatidic acid, and the like, and more preferred are lysophosphatidylcholine (lysolecithin).

[0037] Examples of the ethylene glycol alkyl ether include polyoxyethylene alkyl ether, polyoxyethylene lauryl ether, polyoxyethylene palmitoyl ether, polyoxyethylene stearyl ether, etc. Commercially available ethylene glycol alkyl ethers may also be used, and examples of such products include Emulgen 102KG, Emulgen 103, Emulgen 104P, Emulgen 105, and Emulgen 106 from the Emulgen (registered trademark) series and Emanone (registered trademark) series of Kao Corporation. , Emulgen 108, Emulgen 109P, Emulgen 120, Emulgen 123P, Emulgen 130K, Emulgen 147, Emulgen 150, Emulgen 210P, Emulgen 220, Emulgen 306P, Emulgen 320P, Emulgen 350, Emulgen 404, Emulgen 408, Emulgen 409PV, Emulgen 420, Emulgen 430, Emulgen 7 05, Emulgen 707, Emulgen 709, Emulgen 1108, Emulgen 1118S-70, Emulgen 1135S-70, Emulgen 1150S-60, Emulgen 4085, Emulgen 2020G-HA, Emulgen 2025G, Emanone 1112, Emanone 3199V, Emanone 3299V, Emanone 3299RV, and Emanone 4110. More preferred are Emulgen 103, Emulgen 104P, Emulgen 105, Emulgen 106, Emulgen 108, Emulgen 109P, Emulgen 210P, Emulgen 306P, Emulgen 320P, Emulgen 404, Emulgen 408, Emulgen 409PV, Emulgen 420, Emulgen 705, Emulgen 707, Emulgen 709, Emulgen 1108, Emulgen 2020G-HA, Emanone 1112, and Emanone 4110, all of which are manufactured by Kao Corporation. More preferred are Emulgen 104P, Emulgen 105, Emulgen 106, Emulgen 108, Emulgen 210P, Emulgen 306P, Emulgen 408, Emulgen 409PV, Emulgen 705, Emulgen 707, Emulgen 709, Emulgen 1108, Emulgen 2020G-HA, Emanone 1112, and Emanone 4110 from Kao Corporation. In addition, they may be appropriately selected from the NIKKOL (registered trademark) series from Nikko Chemicals Co., Ltd. For example, NIKKOL BT-5, NIKKOL BT-7, NIKKOL BT-9, and NIKKOL BT-12.

[0038] Examples of the polyglycerol fatty acid ester include glycerol fatty acid partial esters such as glyceryl stearate, glyceryl isostearate, glyceryl palmitate, glyceryl myristate, glyceryl oleate, glyceryl coconut oil fatty acid, glycerol monocottonseed oil fatty acid, glycerol monoerucate, glycerol sesquioleate, glycerol α,α'-oleic acid pyroglutamate, and glycerol monostearate malate; polyglyceryl-2, 3, 4, 5, 6, 8, and 10 stearate, polyglyceryl-6, 10 distearate, and polyglyceryl-10 tristearate. Examples of polyglyceryl-2 diisostearate (diglyceryl diisostearate) include polyglyceryl-2 triisostearate, polyglyceryl-2 tetraisostearate, polyglyceryl-10 decaisostearate, polyglyceryl-2 oleate, polyglyceryl-2 dioleate, polyglyceryl-2 trioleate, and polyglyceryl-10 decaoleate.

[0039] Examples of polyoxyethylene polyoxypropylene alkyl ethers include Emulgen (registered trademark) LS-106, Emulgen LS-110, Emulgen LS-114, and Emulgen MS-110 from Kao Corporation, and NIKKOL (registered trademark) PBC-31, NIKKOL PBC-33, NIKKOL PBC-34, and NIKKOL PBC-41, NIKKOL PBC-44, NIKKOL PBN-4612, NIKKOL PBN-4620, NIKKOL PBN-4630. More preferably, Emulgen LS-106, Emulgen LS-110, Emulgen LS-114, Emulgen MS-110. Even more preferably, Emulgen LS-106, Emulgen LS-110, Emulgen MS-110.

[0040] The surfactant used in the present invention preferably has an HLB (Hydrophile-Lipophile Balance) value of 8 to 20. More preferably, the HLB value is 8 to 14. Examples of such surfactants include sorbitan isostearate, steareth-8, beheneth-10, laureth-5, ceteth-7, oleth-8, PEG-8 glyceryl isostearate, cholestane-10, PEG-10BG isostearate, PEG-30 glyceryl triisostearate, PEG-30 glyceryl triisostearate, PEG-30 glyceryl trioleate, PEG-30 trimethylol triisostearate, and PEG-30 trimethylol triisostearate. propyl alcohol, PEG-30 hydrogenated castor oil laurate, PCA PEG-30 hydrogenated castor oil isostearate, octyldodeceth-10, PEG-12 dilaurate, sorbeth-40 tetraoleate, polyglyceryl-10 diisostearate, PEG-20 glyceryl diisostearate, PEG-8 isostearate, PEG-10 glyceryl isostearate, PEG-60 hydrogenated castor oil triisostearate, PPG-2-deceth-10 S-7, Oleth-10, Hydrogenated Dimer Dilinoleth-20, Sorbitan Cocoate, Isostearate-10, Steareth-11, PEG-30 Trimethylolpropane Trimyristate, PEG-40 Hydrogenated Castor Oil Isostearate, PEG-40 Hydrogenated Castor Oil Isostearate, PCA PEG-40 Hydrogenated Castor Oil Isostearate, Laureth-7, Isoceteth-10, Ceteth-10, PEG-10 Isostearate, PE Stearate G-10, PEG-10 oleate, PEG-10 glyceryl stearate, oleth-12, decyltetradeceth-15, cholestyryl-15, PEG-16 dilaurate, PEG-30 hydrogenated castor oil, PEG-40 glyceryl triisostearate, PEG-40 glyceryl trioleate, PEG-40 trimethylolpropane triisostearate, PEG-40 hydrogenated castor oil laurate, and PEG-12 laurate.

[0041] In the present invention, the amount of the surfactant is, for example, 1 to 20% by mass, preferably 1 to 10% by mass, and more preferably 1 to 5% by mass, based on the total mass of the resulting solid base material for external use on the skin. In the present invention, the amount of the surfactant to be added is, for example, 1 to 20% by mass, preferably 2 to 10% by mass, based on the total mass of the resulting aqueous composition. The surfactant used in the present invention is at least one of the above-mentioned surfactant groups, and these surfactants can be used alone or in combination of two or more.

[0042] The hair cosmetic of the present invention may contain additives that can be generally used as additives for cosmetics, additives for quasi-drugs, and additives for pharmaceuticals, as necessary. Examples of such additives include oily bases, moisturizing agents, feel-improving agents, surfactants other than those mentioned above, polymers, thickening / gelling agents, solvents, antioxidants, reducing agents, oxidizing agents, preservatives, antibacterial agents, bactericides, chelating agents, pH adjusters, acids, alkalis, inorganic salts, UV absorbers, vitamins and derivatives thereof, hair growth agents, blood circulation promoters, stimulants, hormones, anti-wrinkle agents, anti-aging agents, cooling agents, warming agents, wound healing promoters, irritation relief agents, cell activators, plant / animal / microbial extracts, antipruritic agents, keratin exfoliating / dissolving agents, antiperspirants, cooling agents, astringents, enzymes, nucleic acids, fragrances, anti-inflammatory agents, and anti-inflammatory agents. The content of these other additives may vary depending on the type, but may be, for example, about 0.001% to 20% by mass, or about 0.01% to 10% by mass, relative to the total mass of the hair cosmetic.

[0043] The hair cosmetic composition of the present invention can be produced, for example, by mixing and stirring at least one type of lipid peptide compound, water, and other ingredients as desired with heating, and then leaving the mixture to cool.

[0044] The hair cosmetic composition of the present invention can be used by blending it with other hair cosmetic compositions. The hair cosmetic composition of the present invention can also exert its effects even if it is applied to hair and then washed with water or the like. In the present invention, "applying a hair cosmetic to hair" includes applying the hair cosmetic to the hair by taking the hair cosmetic on the hand or a brush, and applying the hair cosmetic directly to the hair. This means that the hair cosmetic comes into contact with the hair. In the examples, bleached hair was prepared to simulate a damaged hair cuticle CMC. In addition, applying a hair cosmetic to bleached hair in the examples increased the tensile strength of the hair, which also meant that the hair cuticle CMC was repaired. EXAMPLES

[0045] The present invention will be described in more detail below with reference to examples, but the present invention is not limited to the following examples.

[0046] Comparative Example 1 and Example 1: Tensile strength test of hair treated with conditioner (1) Preparation of premix Pal-GH (N-palmitoyl-glycine-histidine, palmitoyl dipeptide-18), stearic acid as an additive, 1,2-hexanediol, polyoxyethylene lauryl ether (manufactured by Nikko Chemicals Co., Ltd.), and water were added to a 300 mL beaker in the ratios shown in Table 1 below, and the mixture was heated and stirred at 200 rpm at a liquid temperature of 80°C to obtain a homogeneous solution. The mixture was cooled while stirring, and when the liquid temperature reached 60°C, it was left to cool, preparing the ES-01 premix. [Table 1]

[0047] (2) Creating bleached hair EX Hi-Bleach (Mandom Corp.) was applied to 50 strands of black human hair (BS-BA, Bealux Corp.) and left at room temperature for 1 hour to bleach the hair. The hair was then washed with distilled water and dried for 30 minutes in a constant temperature dryer (OF-300B, AS ONE Corp.) set at 60°C. The above operation was repeated three times in total. The hair was then immersed in 1 L of an aqueous solution of 1% by mass of sodium dodecyl sulfate (FUJIFILM Wako Pure Chemical Corp.) dissolved in distilled water, and washed with distilled water. Excess water was removed with Kay Dry (Nippon Paper Crecia Corp.), and the hair was dried at room temperature overnight to prepare bleached hair.

[0048] (3) Preparation of conditioner According to Table 2 below, conditioners of Comparative Example 1 and Example 1 containing 1.5% by mass (wt %) of keratin were prepared. Phase A was heated and stirred to 75°C in a 200mL beaker (HARIO Corporation). Phase B and Phase C were mixed in a 200mL beaker and heated and stirred to 75°C. Phase A was added to the mixture of Phase B and Phase C, and emulsified at 75°C for 5 minutes at 5000 rpm using a homomixer (Mizuho Kogyo Co., Ltd. QUICK HOMO MIXER LR-1A). Phase D heated to 75°C was then added, heated and stirred for 5 minutes at 75°C, and cooled to 40°C. In the above steps, stirring was performed at 200 rpm. [Table 2]

[0049] (4) Conditioning bleached hair 5.0 g of each of the conditioners of Comparative Example 1 and Example 1 was applied to one bundle (1.8 g) of bleached hair, and after leaving it to stand for 10 minutes, the hair was washed and dried in a thermostatic chamber at 50° C. for 1 hour.

[0050] (5) Hair tensile strength test A tensile strength test was carried out on bleached hair treated with the conditioners of Comparative Example 1 and Example 1, untreated bleached hair, and black hair as a control for healthy hair. Hair samples of 65-70 μm were selected for testing, and processed as shown in Figure 1. The cellophane tape was The length of the thread was about 2 cm, and the length of the cotton thread was about 17 cm. A single hair was fixed at the root and tip (initial load 0.005 N) and pulled at 60 mm / min, and the load at break was measured (N=10). The results are shown in Figure 1. The bleached hair treated with the conditioner of Example 1 had improved tensile strength compared to the untreated bleached hair (control) and the hair treated with the conditioner of Comparative Example 1. It was also confirmed that the strength was close to that of black hair (control, healthy hair). In this test, Example 1 had a tensile strength that was improved by about 0.19 N compared to bleached hair.

[0051] Comparative Example 2 and Example 2 Evaluation of drying time after washing hair treated with conditioner (1) Preparation of conditioner Conditioners of Comparative Example 2 and Example 2 were prepared according to Table 3 below. Phase A was heated and stirred to 75°C in a 200mL beaker (HARIO Corporation). Phase B and Phase C were mixed in a 200mL beaker and heated and stirred to 75°C. Phase A was added to the mixture of Phase B and Phase C, and emulsified at 75°C for 5 minutes at 5000 rpm using a homomixer (Mizuho Kogyo Co., Ltd. QUICK HOMO MIXER LR-1A). Phase D heated to 75°C was then added, heated and stirred for 5 minutes at 75°C, and cooled to 40°C. In the above steps, stirring was performed at 200 rpm. [Table 3]

[0052] (2) Conditioning bleached hair 5.0 g of each of the conditioners of Comparative Example 2 and Example 2 was applied to one bundle (1.8 g) of bleached hair, and after leaving it to stand for 10 minutes, the hair was washed and dried in a thermostatic chamber at 50° C. for 1 hour.

[0053] (3) Evaluation of hair drying time Bleached hair treated with the conditioners of Comparative Example 2 and Example 2, and untreated bleached hair were wetted with water and the drying time when dried with a hair dryer was evaluated. 200 mL of heavy water (Tokyo Chemical Industry Co., Ltd.) was added to a 300 mL tall beaker (HARIO), and each hair was The hairs were left submerged in water for 10 seconds. Excess water was then removed using a towel under the same conditions, and a hair dryer (TESCOM) was applied to each hair from a distance of 20 cm. The state of the heavy water drying after 30 seconds, 1 minute, 2 minutes, 3 minutes, 4 minutes, 5 minutes, 6 minutes, 7 minutes, 8 minutes, 9 minutes, and 10 minutes was evaluated using FT-IR measurement (Nicoleti S50, Thermo Fisher Scientific). The measurement method was ATR, resolution: 8 cm. -1 , Number of times of accumulation: 16, Measurement wavelength: 4000-400cm -1 The drying time was measured at 10 min. Note that in this test, hair was washed with heavy water in order to separate the moisture originally present in the hair from the moisture that was immersed in the hair during washing. The results are shown in FIG. 2. The hair before washing (washing) is indicated as "before" and the time immediately after washing is indicated as "0 min." It was confirmed that the bleached hair treated with the conditioner of Example 2 dried faster than the bleached hair as a control and the bleached hair treated with the conditioner of Comparative Example 2. This is expected to suppress damage caused by the hair being wet and damage caused by the heat of a hair dryer. 2, it was found that the time required to dry 50% of the moisture content increased by washing (immersion) was 50% or more faster in Example 2 than in bleached hair, and 30% or more faster in Example 2 than in Comparative Example 2.

[0054] Comparative Example 2 and Example 3: Evaluation of drying time after washing hair treated with conditioner (1) Preparation of conditioner Conditioners of Comparative Example 2 and Example 3 were prepared according to Table 4 below. Phase A was heated and stirred to 75°C in a 200mL beaker (HARIO Corporation). Phase B and Phase C were mixed in a 200mL beaker and heated and stirred to 75°C. Phase A was added to the mixture of Phase B and Phase C, and emulsified at 75°C for 5 minutes at 5000 rpm using a homomixer (Mizuho Kogyo Co., Ltd. QUICK HOMO MIXER LR-1A). Phase D heated to 75°C was then added, heated and stirred for 5 minutes at 75°C, and cooled to 40°C. In the above steps, stirring was performed at 200 rpm. [Table 4]

[0055] (2) Conditioning bleached hair 5.0 g of each of the conditioners of Comparative Example 2 and Example 3 was applied to one bundle (1.8 g) of bleached hair, and after leaving it for 10 minutes, the hair was washed and towel-dried to remove excess water.

[0056] (3) Evaluation of hair drying time After towel drying the bleached hair treated with the conditioners of Comparative Example 2 and Example 3 and the untreated bleached hair, a hair dryer (manufactured by Panasonic) was applied to each hair from a distance of 10 cm to dry it. The results are shown in Figure 3. The time after towel drying was set as 0 min, and the time after 1 m was set as 0 min. The moisture content was measured after 1 to 5 minutes. The hair weight before washing was measured using a precision balance, and the weight values ​​at each measurement time were subtracted from the original hair weight (moisture weight) and graphed. It was confirmed that the bleached hair treated with the conditioner of Example 3 dried faster than the bleached hair treated with the conditioner of Comparative Example 2. This is expected to suppress damage caused by the hair being wet and damage caused by the heat of a hair dryer.

Claims

1. A hair cosmetic for repairing the CMC of hair cuticles, comprising at least one lipid peptide-type compound consisting of a low molecular weight lipid peptide or a pharmaceutically acceptable salt thereof.

2. 2. The hair cosmetic composition according to claim 1, wherein the lipid peptide-type compound is a compound in which a peptide portion having a repeating amino acid bond structure is bonded to a lipid portion consisting of an aliphatic group having 9 to 23 carbon atoms.

3. The hair cosmetic composition according to claim 2, characterized in that the lipid peptide-type compound consists of at least one of compounds represented by the following formulas (1) to (3) or pharmaceutically acceptable salts thereof: 【Chemical 1】 (In the formula, R １ represents an aliphatic group having 9 to 23 carbon atoms; R ２ represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, which may have a branched chain having 1 or 2 carbon atoms; R ３ Ha-(CH ２ ) ｎ represents an —X group, n is a number from 1 to 4, and X is an amino group, a guanidino group, or —CONH ２ a group, or a 5- or 6-membered ring, or a fused heterocyclic ring composed of a 5- and 6-membered ring, which may have 1 to 3 nitrogen atoms. 【Chemistry 2】 (In the formula, R ４ represents an aliphatic group having 9 to 23 carbon atoms; R ５ ~R ７ are each independently a hydrogen atom, an alkyl group having 1 to 4 carbon atoms which may have a branched chain and which has 1 or 2 carbon atoms, or —(CH ２ ) ｎ represents an —X group, n is a number from 1 to 4, and X is an amino group, a guanidino group, or —CONH ２ a group, or a 5- or 6-membered ring, or a fused heterocyclic ring composed of a 5- and 6-membered ring, which may have 1 to 3 nitrogen atoms. 【Chemistry 3】 (In the formula, R ８ represents an aliphatic group having 9 to 23 carbon atoms; R ９ ~R １２ are each independently a hydrogen atom, an alkyl group having 1 to 4 carbon atoms which may have a branched chain and which has 1 or 2 carbon atoms, or —(CH ２ ) ｎ represents an —X group, n is a number from 1 to 4, and X is an amino group, a guanidino group, or —CONH ２ a group, or a 5- or 6-membered ring, or a fused heterocyclic ring composed of a 5- and 6-membered ring, which may have 1 to 3 nitrogen atoms.

4. The hair cosmetic composition according to claim 3, characterized in that the lipid peptide type compound consists of at least one compound represented by the following formula (1) or a pharmaceutically usable salt thereof: 【Chemistry 4】 (In the formula, R 1 represents an aliphatic group having 9 to 23 carbon atoms, R 2 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms which may have a branched chain and which has 1 or 2 carbon atoms, R 3 represents a -(CH 2 ) n -X group, n represents a number from 1 to 4, and X represents an amino group, a guanidino group, a -CONH 2 group, or a 5- or 6-membered ring or a fused heterocycle composed of a 5- and 6-membered ring which may have 1 to 3 nitrogen atoms.)

5. The hair cosmetic composition according to claim 4, further comprising water, a polyhydric alcohol, and a surfactant.

6. A method for repairing the cuticle CMC of hair, comprising applying the hair cosmetic composition according to any one of claims 1 to 5 to hair.

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