Oil-in-water-type emulsified composition

Abstract

To provide an oil-in-water-type emulsified composition in which ceramides are stably emulsified and dispersed in fine particles by a general-purpose process has a transparent or translucent external appearance, excellent storage stability at a low temperature and a high temperature, and imparts refreshing feeling and smoothness to skin after application while preventing external appearance deterioration associated with freezing / melting.SOLUTION: A transparent or translucent oil-in-water-type emulsified composition contains the following components (A), (B), (C), (D), (E) and (F): (A) ceramides; (B) N-acyl-N-alkyltaurine, N-acyl-L-glutamic acid, anionic surfactant selected from a salt thereof; (C) nonionic surfactant with HLB of 10 or more; (D) dihydric alcohol having a carbon number of 6 to 10; (E) dihydric alcohol having a carbon number of 5 or less; and (F) water.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to an oil-in-water emulsion composition. [Background technology]

[0002] The gaps between the keratinocytes that make up the stratum corneum, the outermost layer of the skin, contain lipids called intercellular lipids. Ceramides, which make up about 50% of the intercellular lipids, are deeply involved in rough and dry skin, and it is known that topical ceramide supplementation can improve the condition of the stratum corneum. However, when solid fats such as ceramides are incorporated into cosmetics, it is difficult to stabilize them in the formulation because the solid fats are highly crystalline and have high melting points. Therefore, techniques for stably incorporating these solid fats are being investigated. For example, Patent Document 1 describes that a lipid microparticle dispersion containing one or more types selected from sterols and their derivatives, a lipid that is solid or semi-solid at 25°C, such as ceramide, and an anionic surfactant, can be stably emulsified and dispersed as fine particles without crystallizing the solid lipids such as ceramides. Patent Document 2 describes that a composition in the form of a nano- or microemulsion containing a nonionic surfactant with an HLB value of 8 to 14, a ceramide compound, and vitamin B3 or a derivative thereof can enhance or improve the penetration of the ceramide compound into the skin. [Prior art documents] [Patent documents]

[0003] [Patent Document 1] JP 2019-119742 A [Patent Document 2] JP 2018-87149 A Summary of the Invention [Problem to be solved by the invention]

[0004] However, even though the compositions of Patent Documents 1 and 2 are transparent at room temperature immediately after production, when they are frozen and then thawed again, they become cloudy due to the aggregation of emulsion particles. In order to prevent this, it was necessary to add a polyol or a thickener, but this had the problem of limiting the feel when used. [Means for solving the problem]

[0005] The present inventors have found that by using a combination of a dihydric alcohol having 6 to 10 carbon atoms and a dihydric alcohol having 5 or less carbon atoms together with ceramides, a specific anionic surfactant, and a nonionic surfactant, it is possible to obtain an oil-in-water emulsion composition that can stably emulsify and disperse ceramides as fine particles using a general-purpose process, has a transparent or translucent appearance, has excellent storage stability at low and high temperatures, and imparts a refreshing feeling and smoothness to the skin after application while preventing deterioration in appearance due to freezing and melting.

[0006] The present invention relates to a composition comprising the following components (A), (B), (C), (D), (E) and (F): (A) Ceramides, (B) an anionic surfactant selected from N-acyl-N-alkyltaurine, N-acyl-L-glutamic acid, and salts thereof; (C) Nonionic surfactants with an HLB value of 10 or higher, (D) a dihydric alcohol having 6 to 10 carbon atoms, (E) a dihydric alcohol having 5 or less carbon atoms, (F)Water The present invention relates to a transparent or translucent oil-in-water emulsion composition comprising: Effect of the Invention

[0007] The oil-in-water emulsion composition of the present invention stably emulsifies and disperses ceramides as fine particles using a general-purpose process, and has a transparent or translucent appearance. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0008] Examples of the ceramides of component (A) used in the present invention include natural ceramides such as ceramides 1, 2, 3, 4, 5, 6, and 7, sphingosine derivatives such as phytosphingosine, and ceramide-like structural substances described in JP-A-62-228048, JP-A-63-216812, JP-A-63-227513, JP-A-64-29347, JP-A-64-31752, and JP-A-8-319263. Specific examples of ceramide-like structural substances that can improve the smoothness of the skin after application and improve the moisturizing effect include compounds represented by the following general formulas (1) and (2).

[0009] [ka]

[0010] [In the formula, R 1b is a hydrocarbon group having 10 to 26 carbon atoms, R 2b represents a hydrocarbon group having 9 to 25 carbon atoms, and X is -(CH2) n - (where n is an integer from 2 to 6).

[0011] [ka]

[0012] (In the formula, R 1 and R 2 are the same or different and each represents a hydrocarbon group having 1 to 40 carbon atoms which may be hydroxylated, and R 3 represents an alkylene group having 1 to 6 carbon atoms or a single bond; R 4 represents a hydrogen atom, an alkoxy group having 1 to 12 carbon atoms, or a 2,3-dihydroxypropyloxy group, provided that R 3 When is a single bond, R 4 is a hydrogen atom.)

[0013] In the general formulas (1) and (2), the hydrocarbon group is preferably an alkyl group or an alkenyl group. An example of a compound of general formula (1) is N-(hexadecyloxyhydroxypropyl)-N-hydroxyethylhexadecanamide, and an example of a compound of general formula (2) is long-chain dibasic acid bis-3-methoxypropylamide. The compound represented by the general formula (1) is a pseudo-type ceramide, a ceramide functional component, which can supplement the function of ceramide and improve skin conditions (such as moisture content).

[0014] From the viewpoints of improving the smoothness of the skin after application and improving the moisturizing effect, component (A) preferably contains one or more types selected from natural ceramides, sphingosines, and the compounds represented by the general formulas (1) and (2), more preferably contains one or more types selected from natural ceramides, sphingosines, and the compounds represented by the general formula (1), even more preferably contains one or more types selected from natural ceramides, phytosphingosine, and N-(hexadecyloxyhydroxypropyl)-N-hydroxyethylhexadecanamide, and even more preferably contains N-(hexadecyloxyhydroxypropyl)-N-hydroxyethylhexadecanamide.

[0015] Component (A) may be used alone or in combination with other components, and from the viewpoint of improving the smoothness of the skin after application, the content is preferably 0.00001% by mass or more of the total composition, more preferably 0.001% by mass or more, even more preferably 0.005% by mass or more, even more preferably 0.03% by mass or more, particularly preferably 0.125% by mass or more, preferably 0.5% by mass or less, more preferably 0.4% by mass or less, even more preferably 0.35% by mass or less, even more preferably 0.27% by mass or less, and particularly preferably 0.23% by mass or less. The content of component (A) in the total composition is preferably 0.00001 to 0.5 mass%, more preferably 0.001 to 0.4 mass%, even more preferably 0.005 to 0.35 mass%, even more preferably 0.03 to 0.27 mass%, and particularly preferably 0.125 to 0.23 mass%.

[0016] The anionic surfactant of component (B) is selected from N-acyl-N-alkyltaurine, N-acyl-L-glutamic acid, and salts thereof. As the N-acyl-N-alkyltaurine and its salt, N-acyl-N-methyltaurine and its salt are preferred, such as N-myristoyl-N-methyltaurine, N-lauroyl-N-methyltaurine, N-stearoyl-N-methyltaurine and their salts, etc. As the N-acyl-N-alkyltaurine salt, sodium salt is preferred, such as sodium N-myristoyl-N-methyltaurine, sodium N-lauroyl-N-methyltaurine, sodium N-stearoyl-N-methyltaurine, etc. Among these, from the viewpoints of forming ceramides into fine particles, improving the transparency of appearance, improving storage stability at low temperatures, and improving storage stability at high temperatures, it is preferable to contain one or more selected from N-lauroyl-N-methyltaurine, N-stearoyl-N-methyltaurine, and salts thereof, it is more preferable to contain N-stearoyl-N-methyltaurine and salts thereof, and it is even more preferable to contain sodium N-stearoyl-N-methyltaurine.

[0017] Examples of N-acyl-L-glutamic acid and salts thereof include N-lauroyl-L-glutamic acid, N-stearoyl-L-glutamic acid, N-myristoyl-L-glutamic acid, and salts thereof, etc. Among these, from the viewpoint of forming ceramides into fine particles, improving the transparency of the appearance, improving storage stability at low temperatures, and improving storage stability at high temperatures, it is preferable to contain one or more selected from N-lauroyl-L-glutamic acid, N-stearoyl-L-glutamic acid, and salts thereof, and it is more preferable to contain N-stearoyl-L-glutamic acid and salts thereof.

[0018] From the viewpoints of forming ceramides into fine particles, improving the transparency of appearance, improving storage stability at low temperatures, and improving storage stability at high temperatures, component (B) preferably contains N-acyl-N-methyltaurine and salts thereof, more preferably contains one or more selected from N-lauroyl-N-methyltaurine, N-stearoyl-N-methyltaurine, and salts thereof, even more preferably contains N-stearoyl-N-methyltaurine and salts thereof, and even more preferably contains sodium N-stearoyl-N-methyltaurine.

[0019] One or more types of component (B) can be used, and from the viewpoints of converting ceramides into fine particles, improving the transparency of appearance, improving storage stability at low temperatures, improving storage stability at high temperatures, and improving skin smoothness after application, the content is preferably 0.001 mass% or more of the total composition, more preferably 0.015 mass% or more, even more preferably 0.023 mass% or more, even more preferably 0.028 mass% or more, particularly preferably 0.048 mass% or more, preferably 0.5 mass% or less, more preferably 0.35 mass% or less, even more preferably 0.2 mass% or less, even more preferably 0.09 mass% or less, and particularly preferably 0.07 mass% or less. The content of component (B) in the total composition is preferably 0.001 to 0.5 mass%, more preferably 0.015 to 0.35 mass%, even more preferably 0.023 to 0.2 mass%, even more preferably 0.028 to 0.09 mass%, and particularly preferably 0.048 to 0.07 mass%.

[0020] In the present invention, the mass ratio (A) / (B) of component (A) to component (B) is preferably 2 or more, more preferably 2.2 or more, even more preferably 2.7 or more, even more preferably 2.9 or more, preferably 7 or less, more preferably 6 or less, even more preferably 5 or less, and even more preferably 4.5 or less, from the viewpoint of making ceramides into fine particles, improving the transparency of the appearance, improving the storage stability at low temperatures, improving the storage stability at high temperatures, and suppressing the deterioration of the appearance due to freezing and melting. In addition, the mass ratio (A) / (B) of component (A) to component (B) is preferably 2 to 7, more preferably 2.2 to 6, even more preferably 2.7 to 5, and even more preferably 2.9 to 4.5.

[0021] The nonionic surfactant of component (C) has an HLB of 10 or more, and from the viewpoints of converting ceramides into fine particles, improving the transparency of the appearance, improving storage stability at high temperatures, and suppressing deterioration of the appearance due to freezing and melting, an HLB of 11 to 16 is preferable, and an HLB of 12 to 15 is more preferable. Here, HLB (Hydrophilic-Lipophilic Balance) indicates the molecular weight of the hydrophilic group portion in the total molecular weight of the surfactant, and is calculated by Griffin's formula. When a surfactant is composed of two or more nonionic surfactants, the HLB of the mixed surfactant is calculated as follows. The HLB of the mixed surfactant is the phase arithmetic average of the HLB values ​​of each nonionic surfactant based on their blending ratio. Mixed HLB=Σ(HLBx×Wx) / ΣWx HLBx indicates the HLB value of the nonionic surfactant X. Wx represents the mass (g) of the nonionic surfactant X having the value of HLBx.

[0022] Examples of such nonionic surfactants include polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyoxyethylene alkanol ether, polyglycerin fatty acid ester, sucrose fatty acid ester, etc. Among these, from the viewpoints of forming ceramides into fine particles, improving the transparency of the appearance, improving storage stability at high temperatures, and suppressing deterioration of the appearance due to freezing and melting, it is preferable to contain one or more selected from polyoxyethylene hydrogenated castor oil and polyoxyethylene sorbitan fatty acid ester, and it is more preferable to contain polyoxyethylene hydrogenated castor oil.

[0023] In addition, in the polyoxyethylene hydrogenated castor oil, the average number of moles of polyoxyethylene chains added that constitute the polyoxyethylene hydrogenated castor oil is preferably 25 to 100, more preferably 35 to 85, even more preferably 45 to 75, even more preferably 55 to 65, and particularly preferably 60, from the viewpoints of forming ceramides into fine particles, improving the transparency of the appearance, improving the storage stability at high temperatures, and suppressing deterioration of the appearance due to freezing and melting.

[0024] In the polyoxyethylene sorbitan fatty acid ester, from the viewpoints of forming ceramides into fine particles, improving the transparency of the appearance, improving storage stability at high temperatures, and suppressing deterioration of the appearance due to freezing and melting, the average number of added moles of polyoxyethylene chains constituting the polyoxyethylene sorbitan fatty acid ester is preferably 10 to 30, more preferably 15 to 25, and even more preferably 20. In the polyoxyethylene sorbitan fatty acid ester, from the viewpoints of forming ceramides into fine particles, improving the transparency of the appearance, improving storage stability at high temperatures, and suppressing deterioration of the appearance due to freezing and melting, the average number of carbon atoms of the alkyl group constituting the polyoxyethylene sorbitan fatty acid ester is preferably 10 to 25, more preferably 16 to 20, and even more preferably 18, from the viewpoints of forming ceramides into fine particles, improving the transparency of the appearance, improving storage stability at high temperatures, and suppressing deterioration of the appearance due to freezing and melting.

[0025] The nonionic surfactant of component (C) can be used alone or in combination of two or more, and from the viewpoint of making ceramides into fine particles, improving the transparency of the appearance, improving storage stability at high temperatures, suppressing the deterioration of the appearance due to freezing and melting, and improving the refreshing feeling of the skin after application, the content is preferably 0.1 mass% or more in the total composition, more preferably 0.13 mass% or more, even more preferably 0.2 mass% or more, more preferably 0.26 mass% or more, preferably 4 mass% or less, more preferably 2 mass% or less, even more preferably 0.7 mass% or less, and even more preferably 0.35 mass% or less. The content of component (C) is preferably 0.1 to 4 mass% in the total composition, more preferably 0.13 to 2 mass%, more preferably 0.2 to 0.7 mass%, and even more preferably 0.26 to 0.35 mass%.

[0026] Component (D) is a dihydric alcohol having 6 to 10 carbon atoms. Examples of component (D) include triethylene glycol, dipropylene glycol, tripropylene glycol, and the like, and it is preferable to include dipropylene glycol.

[0027] Component (D) can be used alone or in combination of two or more, and from the viewpoint of dissolving ceramides in the manufacturing process, turning ceramides into fine particles, improving the transparency of the appearance, improving storage stability at low temperatures, and improving the refreshing feeling of the skin after application, the content is preferably 0.1 mass% or more in the total composition, more preferably 0.13 mass% or more, even more preferably 0.15 mass% or more, even more preferably 0.3 mass% or more, preferably 10 mass% or less, more preferably 6 mass% or less, even more preferably 3 mass% or less, and even more preferably 1 mass% or less. The content of component (D) is preferably 0.1 to 10 mass% in the total composition, more preferably 0.13 to 6 mass%, even more preferably 0.15 to 3 mass%, and even more preferably 0.3 to 1 mass%.

[0028] In the present invention, the mass ratio (B) / (D) of component (B) to component (D) is preferably 0.005 or more, more preferably 0.01 or more, even more preferably 0.02 or more, even more preferably 0.06 or more, preferably 7 or less, more preferably 1 or less, even more preferably 0.5 or less, and even more preferably 0.2 or less, from the viewpoint of making ceramides into fine particles, improving the transparency of the appearance, improving the storage stability at low temperatures, improving the storage stability at high temperatures, suppressing the deterioration of the appearance due to freezing and melting, improving the refreshing feeling of the skin after application, and improving the smoothness of the skin after application. In addition, the mass ratio (B) / (D) of component (B) to component (D) is preferably 0.005 to 7, more preferably 0.01 to 1, even more preferably 0.02 to 0.5, and even more preferably 0.06 to 0.2.

[0029] Component (E) is a dihydric alcohol having 5 or less carbon atoms. Examples of component (E) include ethylene glycol, diethylene glycol, propylene glycol, 1,3-butylene glycol, etc., and from the viewpoints of converting ceramides into fine particles, improving the transparency of the appearance, improving storage stability at high temperatures, suppressing deterioration of the appearance due to freezing and melting, and improving the refreshing feeling on the skin after application, it is preferable to include one or more selected from propylene glycol and 1,3-butylene glycol, and it is more preferable to include 1,3-butylene glycol.

[0030] Component (E) can be used alone or in combination of two or more, and from the viewpoint of making ceramides into fine particles, improving the transparency of the appearance, improving the storage stability at low temperatures, improving the storage stability at high temperatures, suppressing the deterioration of the appearance due to freezing and melting, and improving the refreshing feeling of the skin after application, the content is preferably 0.1 mass% or more in the total composition, more preferably 0.5 mass% or more, more preferably 1.7 mass% or more, even more preferably 2 mass% or more, preferably 10 mass% or less, more preferably 7.5 mass% or less, even more preferably 2.7 mass% or less, and even more preferably 4 mass% or less. The content of component (E) is preferably 0.1 to 10 mass% in the total composition, more preferably 0.5 to 7.5 mass%, more preferably 1.7 to 2.7 mass%, and even more preferably 2 to 4 mass%.

[0031] In the present invention, the total content (D)+(E) of components (D) and (E) is preferably 0.1% by mass or more in the entire composition, more preferably 1% by mass or more, even more preferably 2.3% by mass or more, even more preferably 2.8% by mass or more, especially preferably 3% by mass or more, preferably 15% by mass or less, more preferably 12% by mass or less, even more preferably 9% by mass or less, even more preferably 5.5% by mass or less, especially preferably 5% by mass or less. The total content (D)+(E) of components (D) and (E) is preferably 0.1-15% by mass in the entire composition, more preferably 1-12% by mass, even more preferably 2.3-9% by mass, even more preferably 2.8-5.5% by mass, especially preferably 3-5% by mass.

[0032] In the present invention, the mass ratio (D) / (E) of component (D) to component (E) is, from the viewpoints of forming ceramides into fine particles, improving the transparency of appearance, improving storage stability at low temperatures, improving storage stability at high temperatures, suppressing deterioration of appearance due to freezing and melting, improving the refreshing feeling of the skin after application, and improving the smoothness of the skin after application, preferably 0.01 or more, more preferably 0.02 or more, even more preferably 0.04 or more, even more preferably 0.06 or more, particularly preferably 0.08 or more, more preferably 0.2 or more, preferably 10 or less, more preferably 5 or less, even more preferably 2 or less, even more preferably 1.4 or less, particularly preferably 1 or less, and more preferably 0.56 or less. Furthermore, the mass ratio (D) / (E) of component (D) to component (E) is preferably 0.01 to 10, more preferably 0.02 to 5, even more preferably 0.04 to 2, still more preferably 0.06 to 1.4, particularly preferably 0.08 to 1, and more preferably 0.2 to 0.56.

[0033] In the present invention, the content of water in component (F) is preferably 50% by mass or more, more preferably 60% by mass or more, and even more preferably 70% by mass or more, and is preferably 99% by mass or less, more preferably 95% by mass or less, and even more preferably 90% by mass or less, in terms of improving the refreshing feeling on the skin after application and improving the stability at high temperatures. The content of water in component (F) is preferably 50 to 99% by mass, more preferably 60 to 95% by mass, and even more preferably 70 to 90% by mass, in the entire composition.

[0034] The oil-in-water emulsion composition of the present invention further contains (G) a basic amino acid, which converts the ceramides into fine particles, improves the transparency of the appearance, improves the storage stability at high temperatures, and suppresses deterioration of the appearance due to freezing and melting. Examples of basic amino acids include arginine, lysine, histidine, etc., and it is preferable to include arginine from the viewpoints of forming ceramides into fine particles, improving the transparency of the appearance, improving storage stability at high temperatures, and suppressing deterioration of the appearance due to freezing and melting.

[0035] Component (G) can be used alone or in combination of two or more, and from the viewpoint of making ceramides into fine particles, improving the transparency of the appearance, improving storage stability at high temperatures, and suppressing the deterioration of the appearance due to freezing and melting, the content is preferably 0.01 mass% or more in the total composition, more preferably 0.02 mass% or more, even more preferably 0.05 mass% or more, even more preferably 0.1 mass% or more, preferably 1 mass% or less, more preferably 0.8 mass% or less, even more preferably 0.5 mass% or less, and even more preferably 0.2 mass% or less. The content of component (G) is preferably 0.01 to 1 mass% in the total composition, more preferably 0.02 to 0.8 mass%, even more preferably 0.05 to 0.5 mass%, and even more preferably 0.1 to 0.2 mass%.

[0036] The oil-in-water emulsion composition of the present invention may contain, in addition to the above-mentioned components, components that are usually used in cosmetics, such as oil components other than those mentioned above, surfactants other than those mentioned above, water-soluble polymers, antioxidants, fragrances, preservatives, pH adjusters, blood circulation promoters, cooling agents, antiperspirants, germicides, skin activators, moisturizers, cooling agents, colorants, etc. From the viewpoint of usability, the content of oil components other than component (A) in the oil-in-water emulsion composition of the present invention is preferably 15% by mass or less, more preferably 5% by mass or less, even more preferably 1% by mass or less, even more preferably 0.5% by mass or less, and particularly preferably 0.1% by mass or less.

[0037] The oil-in-water emulsion composition of the present invention can be produced according to a conventional method. For example, the components (A) to (E) and other oily components are heated and stirred to prepare an oily component dissolved phase in which they are uniformly dissolved, and then an aqueous phase in which an aqueous component containing the component (F) is heated and mixed is added to the oily component dissolved phase and stirred.Then, the mixture is cooled to obtain an oil-in-water emulsion composition.

[0038] The oil-in-water emulsion composition of the present invention has a transparent or translucent appearance. "Transparent" means that the transmittance is 70% or more compared to pure water. Moreover, "semi-transparent" refers to a transmittance of less than 70% and 40% or more relative to pure water. In the present invention, the transmittance is the proportion of light at a wavelength of 550 nm that transmits through an oil-in-water emulsion composition at 25° C., and is calculated relative to pure water being 100%. In addition, the oil-in-water emulsion composition of the present invention has excellent storage stability at both low and high temperatures, and can impart a refreshing feeling and smoothness to the skin after application while preventing deterioration of appearance due to freezing and melting.

[0039] In addition, from the viewpoint of making the oil-in-water emulsion composition of the present invention transparent or semi-transparent in appearance and improving storage stability at high temperatures, the average particle size of the emulsion particles is preferably 10 nm or more, more preferably 40 nm or more, even more preferably 60 nm or more, even more preferably 90 nm or more, preferably 200 nm or less, more preferably 170 nm or less, even more preferably 135 nm or less, and even more preferably 110 nm or less. In addition, the average particle size of the emulsion particles is preferably 10 to 200 nm, more preferably 40 to 170 nm, even more preferably 60 to 135 nm, and even more preferably 90 to 110 nm. In the present invention, the average particle size of the emulsion particles is measured by diluting each oil-in-water emulsion composition 20 times and using a Zetasizer Nano Z manufactured by Malvern.

[0040] From the viewpoint of improving a refreshing feeling on the skin after application, the oil-in-water emulsion composition of the present invention has a viscosity at 25° C. of preferably 1 mPa·s or more, more preferably 2 mPa·s or more, even more preferably 5 mPa·s or more, preferably 50 mPa·s or less, more preferably 30 mPa·s or less, and even more preferably 20 mPa·s or less. Moreover, the viscosity at 25° C. is preferably 1 to 50 mPa·s, more preferably 2 to 30 mPa·s, and even more preferably 5 to 20 mPa·s. In the present invention, the viscosity is measured using a TVB-10 type viscometer, rotor 1, 60 rpm, 1 minute, and 25°C.

[0041] The oil-in-water emulsion composition of the present invention is suitable as an oil-in-water emulsion cosmetic. For example, it can be used as a skin cosmetic such as a skin care cosmetic such as a lotion, milky lotion, or serum, and is suitable as a lotion having a transparent or translucent appearance.

[0042] In relation to the above-mentioned embodiment, the present invention further discloses the following compositions, etc.

[0043] <1> The following components (A), (B), (C), (D), (E) and (F): (A) Ceramides, (B) an anionic surfactant selected from N-acyl-N-alkyltaurine, N-acyl-L-glutamic acid, and salts thereof; (C) Nonionic surfactants with an HLB value of 10 or higher, (D) a dihydric alcohol having 6 to 10 carbon atoms, (E) a dihydric alcohol having 5 or less carbon atoms, (F)Water A transparent or translucent oil-in-water emulsion composition comprising:

[0044] <2> The ceramides of component (A) are preferably natural ceramides, sphingosines, and ceramides represented by the following general formulas (1) and (2):

[0045] [ka]

[0046] [In the formula, R 1b is a hydrocarbon group having 10 to 26 carbon atoms, R 2b represents a hydrocarbon group having 9 to 25 carbon atoms, and X is -(CH2) n - (where n is an integer from 2 to 6).

[0047] [ka]

[0048] (In the formula, R 1 and R 2are the same or different and each represents a hydrocarbon group having 1 to 40 carbon atoms which may be hydroxylated, and R 3 represents an alkylene group having 1 to 6 carbon atoms or a single bond; R 4 represents a hydrogen atom, an alkoxy group having 1 to 12 carbon atoms, or a 2,3-dihydroxypropyloxy group, provided that R 3 When is a single bond, R 4 is a hydrogen atom.) It is more preferable that the composition contains one or more selected from natural ceramides, sphingosines, and compounds represented by the general formula (1), and it is even more preferable that the composition contains one or more selected from natural ceramides, phytosphingosine, and N-(hexadecyloxyhydroxypropyl)-N-hydroxyethylhexadecanamide, and it is even more preferable that the composition contains N-(hexadecyloxyhydroxypropyl)-N-hydroxyethylhexadecanamide. <1> The oil-in-water emulsion composition described above.

[0049] <3> The content of component (A) in the entire composition is preferably 0.00001% by mass or more, more preferably 0.001% by mass or more, even more preferably 0.005% by mass or more, even more preferably 0.03% by mass or more, and particularly preferably 0.125% by mass or more, preferably 0.5% by mass or less, more preferably 0.4% by mass or less, even more preferably 0.35% by mass or less, even more preferably 0.27% by mass or less, and particularly preferably 0.23% by mass or less. <1> or <2> The oil-in-water emulsion composition described above.

[0050] <4> The component (B) preferably contains N-acyl-N-methyltaurine and salts thereof, more preferably contains one or more selected from N-lauroyl-N-methyltaurine, N-stearoyl-N-methyltaurine and salts thereof, further preferably contains N-stearoyl-N-methyltaurine and salts thereof, and further preferably contains sodium N-stearoyl-N-methyltaurine. <1> ~ <3> 10. The oil-in-water emulsion composition according to claim 1 . <5> The content of component (B) in the entire composition is preferably 0.001% by mass or more, more preferably 0.015% by mass or more, even more preferably 0.023% by mass or more, even more preferably 0.028% by mass or more, and particularly preferably 0.048% by mass or more, and is preferably 0.5% by mass or less, more preferably 0.35% by mass or less, even more preferably 0.2% by mass or less, even more preferably 0.09% by mass or less, and particularly preferably 0.07% by mass or less. <1> ~ <4> 10. The oil-in-water emulsion composition according to claim 1 .

[0051] <6> The mass ratio (A) / (B) of component (A) to component (B) is preferably 2 or more, more preferably 2.2 or more, even more preferably 2.7 or more, even more preferably 2.9 or more, and is preferably 7 or less, more preferably 6 or less, even more preferably 5 or less, and even more preferably 4.5 or less. <1> ~ <5> 10. The oil-in-water emulsion composition according to claim 1 .

[0052] <7> The component (C) preferably has an HLB of 11 to 16, more preferably an HLB of 12 to 15. <1> ~ <6> 10. The oil-in-water emulsion composition according to claim 1 . <8> The component (C) preferably contains one or more selected from polyoxyethylene hydrogenated castor oil and polyoxyethylene sorbitan fatty acid ester, and more preferably contains polyoxyethylene hydrogenated castor oil. <1> ~ <7> 10. The oil-in-water emulsion composition according to claim 1 . <9> The content of component (C) is preferably 0.1% by mass or more, more preferably 0.13% by mass or more, even more preferably 0.2% by mass or more, even more preferably 0.26% by mass or more, and is preferably 4% by mass or less, more preferably 2% by mass or less, even more preferably 0.7% by mass or less, and even more preferably 0.35% by mass or less, based on the total composition. <1> ~ <8> 10. The oil-in-water emulsion composition according to claim 1 .

[0053] <10> The component (D) preferably comprises dipropylene glycol. <1> ~ <9> 10. The oil-in-water emulsion composition according to claim 1 . <11> The content of component (D) is preferably 0.1% by mass or more in the total composition, more preferably 0.13% by mass or more, even more preferably 0.15% by mass or more, even more preferably 0.3% by mass or more, and is preferably 10% by mass or less, more preferably 6% by mass or less, even more preferably 3% by mass or less, and even more preferably 1% by mass or less. <1> ~ <10> 10. The oil-in-water emulsion composition according to claim 1 . <12> The mass ratio (B) / (D) of component (B) to component (D) is preferably 0.005 or more, more preferably 0.01 or more, even more preferably 0.02 or more, even more preferably 0.06 or more, and is preferably 7 or less, more preferably 1 or less, even more preferably 0.5 or less, and even more preferably 0.2 or less. <1> ~ <11> 10. The oil-in-water emulsion composition according to claim 1 .

[0054] <13> The component (E) preferably contains one or more selected from propylene glycol and 1,3-butylene glycol, and more preferably contains 1,3-butylene glycol. <1> ~ <12> 10. The oil-in-water emulsion composition according to claim 1 . <14> The content of component (E) is preferably 0.1% by mass or more in the total composition, more preferably 0.5% by mass or more, even more preferably 1.7% by mass or more, even more preferably 2% by mass or more, and is preferably 10% by mass or less, more preferably 7.5% by mass or less, even more preferably 2.7% by mass or less, and even more preferably 4% by mass or less. <1> ~ <13> 10. The oil-in-water emulsion composition according to claim 1 .

[0055] <15> The total content (D)+(E) of components (D) and (E) is preferably 0.1% by mass or more in the total composition, more preferably 1% by mass or more, even more preferably 2.3% by mass or more, even more preferably 2.8% by mass or more, and particularly preferably 3% by mass or more, preferably 15% by mass or less, more preferably 12% by mass or less, even more preferably 9% by mass or less, even more preferably 5.5% by mass or less, and particularly preferably 5% by mass or less. <1> ~ <14> 10. The oil-in-water emulsion composition according to claim 1 . <16> the mass ratio (D) / (E) of component (D) to component (E) is preferably 0.01 or more, more preferably 0.02 or more, even more preferably 0.04 or more, even more preferably 0.06 or more, particularly preferably 0.08 or more, more preferably 0.2 or more, preferably 10 or less, more preferably 5 or less, even more preferably 2 or less, even more preferably 1.4 or less, particularly preferably 1 or less, and more preferably 0.56 or less; <1> ~ <15> 10. The oil-in-water emulsion composition according to claim 1 .

[0056] <17> The content of water in the component (F) is preferably 50% by mass or more, more preferably 60% by mass or more, and even more preferably 70% by mass or more, and is preferably 99% by mass or less, more preferably 95% by mass or less, and even more preferably 90% by mass or less, based on the total composition. <1> ~ <16> 10. The oil-in-water emulsion composition according to claim 1 .

[0057] <18> Furthermore, it is preferable that the composition further contains (G) a basic amino acid, and more preferably contains arginine. <1> ~ <17> 10. The oil-in-water emulsion composition according to claim 1 . <19> The content of component (G) is preferably 0.01% by mass or more, more preferably 0.02% by mass or more, even more preferably 0.05% by mass or more, even more preferably 0.1% by mass or more, and is preferably 1% by mass or less, more preferably 0.8% by mass or less, even more preferably 0.5% by mass or less, and even more preferably 0.2% by mass or less, based on the total composition. <18> The oil-in-water emulsion composition described above.

[0058] <20> The content of oil components other than component (A) is preferably 15% by mass or less, more preferably 5% by mass or less, even more preferably 1% by mass or less, even more preferably 0.5% by mass or less, and particularly preferably 0.1% by mass or less. <1> ~ <19> 10. The oil-in-water emulsion composition according to claim 1 . <21> The average particle size of the emulsion particles is preferably 10 nm or more, more preferably 40 nm or more, even more preferably 60 nm or more, even more preferably 90 nm or more, and is preferably 200 nm or less, more preferably 170 nm or less, even more preferably 135 nm or less, and even more preferably 110 nm or less. <1> ~ <20> 10. The oil-in-water emulsion composition according to claim 1 .

[0059] <22> The viscosity at 25°C is preferably 1 mPa·s or more, more preferably 2 mPa·s or more, and even more preferably 5 mPa·s or more, and is preferably 50 mPa·s or less, more preferably 30 mPa·s or less, and even more preferably 20 mPa·s or less. <1> ~ <21> 10. The oil-in-water emulsion composition according to claim 1 . <23> Preferably, the cosmetic is an oil-in-water emulsion cosmetic, and more preferably, an oil-in-water emulsion skin cosmetic. <1> ~ <22> 10. The oil-in-water emulsion composition according to claim 1 .

[0060] <24> The following components (A), (B), (C), (D), (E) and (F): (A) 0.00001 to 0.5% by mass of ceramides, (B) 0.001 to 0.5 mass% of an anionic surfactant selected from N-acyl-N-alkyltaurine, N-acyl-L-glutamic acid, and salts thereof, (C) 0.1 to 4 mass% of a nonionic surfactant having an HLB of 10 or more, (D) 0.1 to 10 mass% of a dihydric alcohol having 6 to 10 carbon atoms, (E) 0.1 to 10 mass% of a dihydric alcohol having 5 or less carbon atoms, (F)Water A transparent or translucent oil-in-water emulsion composition comprising:

[0061] <25> The following components (A), (B), (C), (D), (E) and (F): (A) 0.00001 to 0.5 mass% of N-(hexadecyloxyhydroxypropyl)-N-hydroxyethylhexadecanamide, (B) 0.001 to 0.5 mass% sodium N-stearoyl-N-methyl taurate, (C) 0.1 to 4 mass% of polyoxyethylene hydrogenated castor oil having an HLB of 12 to 15, (D) dipropylene glycol 0.1 to 10 mass%, (E) 0.1 to 10 mass% of 1,3-butylene glycol, (F)Water A transparent or translucent oil-in-water emulsion composition comprising:

[0062] <26> The following components (A), (B), (C), (D), (E) and (F): (A) 0.03 to 0.35 mass% of N-(hexadecyloxyhydroxypropyl)-N-hydroxyethylhexadecanamide, (B) 0.001 to 0.2 mass% sodium N-stearoyl-N-methyl taurate, (C) 0.13 to 4 mass% of polyoxyethylene hydrogenated castor oil having an HLB of 12 to 15, (D) dipropylene glycol 0.15 to 10% by mass, (E) 0.5 to 10 mass% of 1,3-butylene glycol, (F)Water A transparent or translucent oil-in-water emulsion composition comprising:

[0063] <27> The following components (A), (B), (C), (D), (E), (F) and (G): (A) 0.00001 to 0.5% by mass of ceramides, (B) 0.001 to 0.5 mass% of an anionic surfactant selected from N-acyl-N-alkyltaurine, N-acyl-L-glutamic acid, and salts thereof, (C) 0.1 to 4 mass% of a nonionic surfactant having an HLB of 10 or more, (D) 0.1 to 10 mass% of a dihydric alcohol having 6 to 10 carbon atoms, (E) 0.1 to 10 mass% of a dihydric alcohol having 5 or less carbon atoms, (F) Water; (G) Basic amino acid 0.01 to 1% by mass A transparent or translucent oil-in-water emulsion composition comprising:

[0064] <28> The following components (A), (B), (C), (D), (E), (F) and (G): (A) 0.00001 to 0.5 mass% of N-(hexadecyloxyhydroxypropyl)-N-hydroxyethylhexadecanamide, (B) 0.001 to 0.5 mass% sodium N-stearoyl-N-methyl taurate, (C) 0.1 to 4 mass% of polyoxyethylene hydrogenated castor oil having an HLB of 12 to 15, (D) dipropylene glycol 0.1 to 10 mass%, (E) 0.1 to 10 mass% of 1,3-butylene glycol, (F) Water; (G) Arginine 0.01 to 1% by mass A transparent or translucent oil-in-water emulsion composition comprising:

[0065] <29> The following components (A), (B), (C), (D), (E), (F) and (G): (A) 0.03 to 0.35 mass% of N-(hexadecyloxyhydroxypropyl)-N-hydroxyethylhexadecanamide, (B) 0.001 to 0.2 mass% sodium N-stearoyl-N-methyl taurate, (C) 0.13 to 4 mass% of polyoxyethylene hydrogenated castor oil having an HLB of 12 to 15, (D) dipropylene glycol 0.15 to 10% by mass, (E) 0.5 to 10 mass% of 1,3-butylene glycol, (F) Water; (G) Arginine 0.05 to 0.5% by mass A transparent or translucent oil-in-water emulsion composition comprising:

[0066] <30> The following components (A), (B), (C), (D), (E) and (F): (A) 0.005 to 0.35% by mass of ceramides, (B) 0.001 to 0.2 mass% sodium N-stearoyl-N-methyl taurate, (C) 0.13 to 4 mass% of polyoxyethylene hydrogenated castor oil having an HLB of 12 to 15, (D) dipropylene glycol 0.15 to 6 mass%, (E) 0.5 to 10 mass% of 1,3-butylene glycol, (F)Water A transparent or translucent oil-in-water emulsion composition comprising the above components, wherein the total content of components (D) and (E), (D)+(E), is 1 to 12 mass%.

[0067] <31> The following components (A), (B), (C), (D), (E) and (F): (A) 0.005 to 0.35% by mass of ceramides, (B) 0.001 to 0.2 mass% sodium N-stearoyl-N-methyl taurate, (C) 0.13 to 4 mass% of one or more nonionic surfactants selected from polyoxyethylene hydrogenated castor oil and polyoxyethylene sorbitan fatty acid esters having an HLB of 12 to 15, (D) dipropylene glycol 0.15 to 6 mass%, (E) 0.5 to 10 mass% of 1,3-butylene glycol, (F)Water A transparent or translucent oil-in-water emulsion composition comprising:

[0068] <32> The following components (A), (B), (C), (D), (E) and (F): (A) 0.005 to 0.35% by mass of ceramides, (B) 0.001 to 0.2 mass% sodium N-stearoyl-N-methyl taurate, (C) 0.13 to 4 mass% of one or more nonionic surfactants selected from polyoxyethylene hydrogenated castor oil and polyoxyethylene sorbitan fatty acid esters having an HLB of 12 to 15, (D) dipropylene glycol 0.15 to 6 mass%, (E) 0.5 to 10 mass% of 1,3-butylene glycol, (F)Water A transparent or translucent oil-in-water emulsion composition comprising the above components, wherein the total content of components (D) and (E), (D)+(E), is 1 to 12 mass%. EXAMPLES

[0069] Examples 1 to 15, Comparative Examples 1 to 4 Oil-in-water emulsion compositions (lotions) having the compositions shown in Table 1 were prepared, and the emulsion particle size immediately after preparation was measured, and the storage stability (appearance, transmittance), refreshing feeling on the skin after application, and smoothness were evaluated. The results are also shown in Table 1.

[0070] (Manufacturing method) Components (A) to (E) and (G) were heated and stirred at 85° C. to prepare an oily component dissolved phase. The remaining components were stirred and mixed at 85° C. to obtain an aqueous phase. The aqueous phase was added to the oily component dissolved phase and cooled with stirring to obtain an oil-in-water emulsion composition.

[0071] (Evaluation method) (1) Particle size (immediately after): Immediately after production, each oil-in-water emulsion composition was diluted 20-fold, and the average particle size of the emulsion particles was measured using a Zetasizer Nano Z manufactured by Malvern.

[0072] (2) Storage stability (appearance): 80 mL of each oil-in-water emulsion composition was placed in a 110 mL transparent glass container (standard size #11, Tokyo Glass Instruments Co., Ltd.), sealed, and stored at each storage temperature for each period. ·-20℃ (storage for 1 day), ·-5℃ (storage for 30 days), ·50℃ (storage for 30 days) Immediately after production and after storage at each storage temperature, each oil-in-water emulsion composition was left to stand at 25° C. for 24 hours, and then its appearance was visually evaluated according to the following criteria. A score of 2 or higher was considered to be acceptable. 3: A transparent, uniform layer without precipitates. 2: No precipitates were observed when the product was left to stand, but slight precipitates were observed that could be seen with the naked eye when the product was gently shaken, but this did not pose any problems in practical use. 1: Precipitation is clearly visible even when the material is left to stand.

[0073] (3) Storage stability (transmittance): Each oil-in-water emulsion composition was stored in the same manner as in (2), and then the transmittance was measured. Note that storage was performed at -20°C and 50°C. The transmittance was calculated using an ultraviolet-visible spectrophotometer (UV1800) manufactured by Shimadzu Corporation, and the proportion of light with a wavelength of 550 nm that transmitted through the oil-in-water emulsion composition (undiluted solution) was calculated with pure water being taken as 100%.

[0074] (4) Skin feels refreshed and smooth after application: Three expert evaluators applied 60 mg of each oil-in-water emulsion composition to the back of the hand and spread it in a 5 cm diameter circle for 20 seconds. After that, the skin's refreshing feeling and smoothness were evaluated after 5 minutes according to the following criteria. The results were shown as the total score of the three evaluators.

[0075] (4-1) Refreshing: 5: Decidedly refreshing. 4: Refreshing. 3: Somewhat refreshing. 2: Slightly sticky. 1: Obviously sticky.

[0076] (4-2) Smoothness: 5: Visibly smooth. 4: Smooth. 3: Somewhat smooth. 2: Not very smooth. 1: Clearly not smooth.

[0077] [Table 1]

[0078] *1: N-(hexadecyloxyhydroxypropyl)-N-hydroxyethylhexadecanamide; sphingolipid E ​​(Kao Corporation), *2: Ceramide 2; Ceramide TIC-001 (manufactured by Takasago International Corporation), *3: Sodium N-stearoyl-N-methyl taurate; Nikkol SMT (manufactured by Nippon Surfactant Industries Co., Ltd.), *4: N-stearoyl-L-glutamic acid; Amisoft HA-P (manufactured by Ajinomoto Co., Ltd.), *5: Polyoxyethylene hydrogenated castor oil (60E.O.); Emanon CH-60 (Kao Corporation) HLB14, *6: Polyoxyethylene sorbitan monostearate (20E.O.); Leodol TW-S120V (Kao Corporation) HLB 14.9

[0079] Prescription examples 1-2 The oil-in-water emulsion compositions (lotions) having the compositions shown in Table 2 were produced in the same manner as in Examples 1 to 15, had a transparent or translucent appearance, and had transmittances immediately after production as shown in Table 2. All of these oil-in-water emulsion compositions have excellent storage stability at low and high temperatures, and impart a refreshing feeling and smoothness to the skin after application while preventing deterioration in appearance due to freezing and melting.

[0080] [Table 2]

Claims

1. The following components (A), (B), (C), (D), (E) and (F): (A) Ceramides, (B) Anionic surfactants selected from N-acyl-N-alkyltaurine, N-acyl-L-glutamic acid, and salts thereof, (C) Nonionic surfactants with an HLB of 10 or more, (D) Dihydric alcohols having 6 to 10 carbon atoms, (E) Dihydric alcohols having 5 or fewer carbon atoms, (F) Water A transparent or translucent oil-in-water emulsion composition containing the above components, wherein the mass ratio (A) / (B) of component (A) to component (B) is 2 to 7.

2. The oil-in-water emulsion composition according to Claim 1, wherein the mass ratio (B) / (D) of component (B) to component (D) is 0.005 to 7.

3. The oil-in-water emulsion composition according to Claim 1 or 2, wherein the mass ratio (D) / (E) of component (D) to component (E) is 0.01 to 10.

4. The oil-in-water emulsion composition according to Claim 1 or 2, wherein the content of component (D) is 0.1 to 10% by mass.

5. The oil-in-water emulsion composition according to Claim 1 or 2, wherein component (C) contains one or more selected from polyoxyethylene hydrogenated castor oil and polyoxyethylene sorbitan fatty acid esters.

6. The oil-in-water emulsion composition according to Claim 1 or 2, further containing (G) basic amino acids.

7. The oil-in-water emulsion composition according to Claim 1 or 2, having a viscosity at 25°C of 1 to 50 mPa·s.