Mixed injection device

Abstract

To efficiently dissolve powder into infusion.SOLUTION: A mixed injection unit (40) performs operation of injecting a part of infusion stored in a syringe into a vial storing powder, operation of extracting the infusion in which the powder has been dissolved, from the vial into which the infusion has been injected, by using the syringe, and operation of mixing the extracted infusion into residual infusion that has not been injected into the vial. The mixed injection unit (40) injects a part of the mixed infusion into a medicine container.SELECTED DRAWING: Figure 4

Description

[Technical field]

[0001] The present disclosure relates to a co-infusion device. [Background technology]

[0002] Patent Document 1 discloses an example of a co-infusion device. The co-infusion device of Patent Document 1 includes a drug filling section and a co-infusion processing section. A user places a drug container, each member that may constitute a syringe, and an infusion container in a predetermined position on a tray placed on a work table of the drug filling section, and then loads the tray into the co-infusion processing section. This allows the co-infusion device of Patent Document 1 to start the co-infusion process. [Prior art documents] [Patent documents]

[0003] [Patent Document 1] JP 2019-063313 A Summary of the Invention [Problem to be solved by the invention]

[0004] However, no specific method for dissolving powdered medicine in an infusion liquid has been disclosed. An object of a first aspect of the present invention is to efficiently dissolve powdered medicine in an infusion liquid.

[0005] Furthermore, Patent Document 1 does not disclose control according to the type of syringe used for mixed injection. The second aspect of the present invention aims to perform control according to the type of the cylindrical tip of the syringe.

[0006] In addition, Patent Document 1 does not disclose control according to the type of needle attached to the syringe used for co-injection. The third aspect of the present invention aims to perform a co-injection operation according to the type of needle attached to the syringe.

[0007] Furthermore, a mechanism for holding the needle is not disclosed in Patent Document 1. An object of the fourth aspect of the present invention is to reduce the possibility that the mechanism for holding the needle will be contaminated by liquid. [Means for solving the problem]

[0008] The co-infusion device according to the first aspect of the present invention comprises an injection unit that injects a portion of the infusion liquid contained in a syringe into a medicine container containing powdered medicine, an extraction unit that uses a syringe to extract the infusion liquid in which the powdered medicine has been dissolved from the medicine container into which the infusion liquid has been injected by the injection unit, a mixing unit that mixes the infusion liquid extracted by the extraction unit with the remaining infusion liquid that was not injected into the medicine container by the injection unit, and an operation control unit that performs the operation of the injection unit, the operation of the extraction unit, and the operation of the mixing unit in this order multiple times.

[0009] A second aspect of the present invention is an injection device that injects a drug contained in a drug container into an infusion container, and is equipped with a first determination unit that determines whether a syringe that extracts the infusion container, a syringe that injects a liquid drug or infusion into the infusion container, a syringe that extracts the liquid drug or infusion contained in the drug container, or a syringe that injects an infusion into the drug container is a center-mouth type syringe or a side-mouth type syringe.

[0010] A co-injection device according to a third aspect of the present invention is a co-injection device that injects a drug contained in a drug container into an infusion contained in an infusion container, and is equipped with an adjustment unit that adjusts the amount of needle puncture into the stopper of the drug container or the stopper of the infusion container, or the puncture position of the needle in the stopper of the drug container or the stopper of the infusion container, depending on the type of needle attached to a syringe that extracts the infusion contained in the infusion container, a syringe that injects a liquid drug or infusion into the infusion container, a syringe that extracts the liquid drug or infusion contained in the drug container, or a syringe that injects an infusion into the drug container.

[0011] A fourth aspect of the present invention provides an infusion device comprising an infusion unit that injects a drug contained in a drug container into an infusion liquid contained in an infusion liquid container, the infusion unit comprising a pair of moving parts that move between positions close to each other and positions away from each other, each of the pair of moving parts having, at the positions close to each other, a clamping portion that clamps a needle of a syringe used for infusion and a non-clamping portion other than the clamping portion, the clamping portion having an insulating material, and at least a portion of the non-clamping portion having a conductive material. Effect of the Invention

[0012] According to the first aspect of the present invention, powdered medicine can be efficiently dissolved in infusion liquid.

[0013] According to the second aspect of the present invention, control can be performed according to the type of the cylindrical tip of the syringe.

[0014] According to the third aspect of the present invention, a mixed injection operation can be performed according to the type of needle attached to the syringe.

[0015] According to the fourth aspect of the present invention, it is possible to reduce the possibility that the mechanism for holding the needle will be contaminated by liquid. [Brief description of the drawings]

[0016] [Figure 1] FIG. 1 is a perspective view showing an example of the overall configuration of a co-infusion device. [Diagram 2] FIG. 2 is a perspective view showing an example of a schematic internal configuration of the co-infusion device when viewed from the front. [Diagram 3] FIG. 2 is a perspective view showing an example of a schematic internal configuration of the co-infusion device when the co-infusion device is viewed from the rear. [Figure 4] FIG. 1 is a block diagram showing an example of the overall configuration of a co-infusion device. [Diagram 5] FIG. 2 is a perspective view showing an example of the configuration of a co-infusion unit. [Figure 6] FIG. 2 is a schematic diagram showing an example of a configuration of a moving unit. [Figure 7]FIG. 2 is a front view showing an example of a schematic configuration of a co-infusion unit. [Figure 8] 11 is a flowchart showing an example of a process flow when powdered medicine contained in a vial is mixed with an infusion liquid. [Figure 9] 13 is a schematic diagram showing an example of the operation of the co-infusion unit when dissolving powdered medicine in an infusion liquid. FIG. [Figure 10] 13 is a schematic diagram showing an example of the operation of the co-infusion unit when extracting an infusion solution containing dissolved powdered medicine from a vial. FIG. [Figure 11] FIG. 1 is a schematic diagram showing an example of the flow when an infusion solution containing dissolved powdered medicine is extracted from a vial. [Figure 12] 10 is a schematic diagram showing an example of an operation when injecting an infusion into a vial. FIG. [Figure 13] 1A and 1B are diagrams showing an example of a needle puncturing state and a through hole formed by the needle puncturing. [Figure 14] FIG. 13 is a diagram for explaining the penetration range of the needle in the stopper. [Figure 15] 1A and 1B are perspective and bottom views showing an example of a center-mouth syringe and a side-mouth syringe. [Figure 16] FIG. 13 is a perspective view showing a modified example of the syringe holding portion. [Figure 17] FIG. 2 is a schematic diagram showing an example of a type of needle attached to a syringe. [Figure 18] FIG. 2 illustrates an example of a needle detection unit. [Figure 19] 11 is a diagram showing an example of a state in which a needle passes through the detection ranges of a first needle detection unit and a second needle detection unit. FIG. [Figure 20] FIG. 13 is a schematic diagram for explaining an example of a projection width of a needle. [Figure 21] FIG. 13 is a diagram showing an example of a co-injection operation when syringes are used successively. [Figure 22] FIG. 2 is a perspective view showing an example of the overall configuration of a syringe shelf and a vial shelf. [Diagram 23] FIG. 2 is a diagram showing an example of the configuration of one syringe shelf and one vial shelf when viewed from the first transporting section side, and a diagram for explaining the vial shelf. [Figure 24]13 is a schematic diagram showing an example of the positional relationship between a nozzle of a syringe held in an instrument holding section and a nozzle detection section. FIG. [Diagram 25] FIG. 13 is a diagram showing a modified example of the instrument holding part. [Figure 26] FIG. 4 is a diagram illustrating an example of a configuration of a second transport unit. [Figure 27] FIG. 2 is a perspective view showing an example of the configuration of an infusion shelf. [Figure 28] 11 is a diagram for explaining an example of a transport method of the second transport section. FIG. [Figure 29] 11 is a diagram for explaining an example of a method for removing an infusion container. FIG. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0017] An embodiment of the present invention will be described in detail below. In each drawing, the X-axis and the Y-axis are two mutually perpendicular axes in a horizontal plane (the ground surface of the co-infusion device 1). The positive X-axis direction may be referred to as the right direction, and the negative X-axis direction as the left direction. The positive Y-axis direction may be referred to as the back direction or rear direction, and the negative Y-axis direction as the front direction or forward direction. The Z-axis is an axis that extends vertically to the XY plane, and the positive Z-axis direction may be referred to as the upward direction, and the negative Z-axis direction as the downward direction.

[0018] [Overall configuration of the co-infusion device] Fig. 1 is a perspective view showing an example of the overall configuration of a co-infusion device 1. As shown in Fig. 1, the co-infusion device 1 according to this embodiment includes a syringe shelf 10, a vial shelf 20, an infusion shelf 30, a printing / inspection unit 50, an infusion receiving shelf 60, a wastebasket section 70, a touch panel 80, and a button 90.

[0019] The co-infusion device 1 is a device that executes a co-infusion process (co-infusion operation) of mixing a medicine and an infusion liquid using a medicine, a syringe, and an infusion liquid indicated in data related to preparation and administration (hereinafter referred to as preparation and administration data). The infusion liquid used in the co-infusion operation may be, for example, saline (physiological saline) or a liquid containing glucose.

[0020] For example, when the medicine indicated in the preparation and administration data is a liquid medicine (liquid medicine), the co-infusion device 1 uses a syringe to aspirate the medicine from a vial (one example of a medicine container) in which the medicine is stored, and injects the medicine from the syringe into an infusion container (infusion bag). When the medicine indicated in the preparation and administration data is a solid medicine (powdered medicine), the co-infusion device 1 uses a syringe to aspirate the infusion from the infusion container, and injects the infusion into the vial. This allows the solid medicine in the vial to be liquid. After that, the co-infusion device 1 uses a syringe to inject the liquid medicine (infusion in which the medicine is dissolved) into the infusion container. The co-infusion device 1 thus performs the co-infusion operation. The co-infusion operation may include an operation of aspirating the medicine from a vial and injecting it into another vial using a syringe. These co-infusion operations are performed by the co-infusion unit 40, which will be described later.

[0021] The co-infusion device 1 allows a user to load a syringe, a vial, and an infusion container into the co-infusion device 1 by opening and closing a door, for example. The air purifying unit described below keeps the inside of the co-infusion device 1 clean, reducing the possibility of contamination of the medicine and the infusion during the co-infusion process. In addition, in order to keep the inside of the co-infusion device 1 clean, the inside of the co-infusion device 1 is kept at a positive pressure.

[0022] The preparation and administration data is data required for the control unit 140 (see FIG. 4) of the co-infusion device 1 to perform the co-infusion process. At least a part of the preparation and administration data may be generated based on prescription data.

[0023] The preparation and administration data includes, for example, information indicating the type of drug used for mixing, the prescribed amount of the drug, information indicating the type of syringe, information indicating the type of infusion (infusion type information), and information indicating the amount of infusion withdrawn from the infusion container. The preparation and administration data may also include information indicating the type of infusion container (e.g., size such as volume). The information indicating the type of drug may include information indicating whether the drug is a powder or liquid. The information indicating the type of syringe may include information indicating whether it is a middle-mouth syringe or a side-mouth syringe, information indicating the size of the syringe, and information indicating the type of needle attached to the syringe.

[0024] Furthermore, the preparation and administration data includes, for example, information about the infusion container into which the drug is injected, such as prescription attribute information such as the name of the patient to whom the drug is prescribed, prescription details such as usage and dosage, an order number indicating the order in which the prescription was received, and infusion type information (e.g., infusion name).

[0025] The preparation and administration data shown above is merely an example, and the information used for mixed injection, which will be described later, may be included in the preparation and administration data.

[0026] The syringe shelf 10 is an equipment storage shelf capable of storing the syringes loaded in the co-infusion device 1. The syringe shelf 10 is provided with a syringe-side door 16. A user can hold the syringe on the syringe shelf 10 by opening and closing the syringe-side door 16.

[0027] The vial shelf 20 is an equipment storage shelf capable of storing the vials filled in the co-infusion device 1. The vial shelf 20 is provided with a vial-side door 27. A user can cause the vial shelf 20 to hold the vial by opening and closing the vial-side door 27.

[0028] The infusion shelf 30 is an infusion storage shelf capable of storing the infusion containers filled in the co-infusion device 1. The infusion shelf 30 is provided with an infusion side door 34. A user can hold the infusion container in the infusion side door 34 by opening and closing the infusion side door 34.

[0029] The syringe side door 16, the vial side door 27, and the infusion side door 34 are doors that can block the user's access to the syringe shelf 10, the vial shelf 20, and the infusion shelf 30, respectively. In the co-infusion device 1, the control unit 140 described later controls the syringe side door 16, the vial side door 27, and the infusion side door 34 so that only one of them is in an unlocked state.

[0030] The printing and inspection unit 50 is a unit that prints a second label and affixes it to the infusion container before or after drug injection. The printing and inspection unit 50 may print an inappropriate information label and affix it to the infusion container after drug injection. The printing and inspection unit 50 is also a unit that weighs the infusion container before and after drug injection.

[0031] A first label, on which, for example, the type of infusion and / or the type of infusion container is printed, is affixed to the infusion container in advance by the pharmaceutical manufacturer that provides the infusion container. The first label is also called an infusion label. Meanwhile, the above-mentioned information on the infusion container into which the medicine has been injected is information that is given to the infusion container into which the medicine is to be injected, and is information different from the information contained in the first label that is affixed to the infusion container in advance. The printing and inspection unit 50 prints the content of this information on a label and affixes it to the infusion container as a second label different from the first label.

[0032] The inappropriate information label is a label on which inappropriate information is printed. The inappropriate information label may be, for example, a label on which an x ​​mark is printed. The inappropriate information may be, for example, information indicating that the weight measured by the printing and inspection unit 50 is inappropriate, and / or information indicating that the type of drug indicated in the preparation and administration data is not included in the information read from the second label. The weight being inappropriate indicates, for example, that the amount of drug injected (prescribed amount) into the infusion container or the amount of infusion withdrawn from the infusion container does not correspond to the amount indicated in the preparation and administration data. The control unit 140 described later judges whether the weight is appropriate and whether the type of drug indicated in the preparation and administration data is included in the information read from the second label.

[0033] The infusion receiving shelf 60 is a unit that receives infusion containers with a second label affixed thereto after drug injection. The infusion receiving shelf 60 is provided with an infusion receiving door 61. The trash can section 70 is a box that receives used syringes. The touch panel 80 has the functions of an operation section that receives various operations by the user, and a display section that displays various information. The operation section and the display section may be provided as separate members. Also, instead of the display section, a presentation section (e.g., a speaker) that presents various information may be provided.

[0034] The button 90 is a mechanical button that can receive a user operation to unlock the syringe side door 16, the vial side door 27, the infusion side door 34, and the infusion receiving door 61. One button 90 is provided for each of the syringe side door 16, the vial side door 27, the infusion side door 34, and the infusion receiving door 61. When the syringe side door 16, the vial side door 27, the infusion side door 34, and the infusion receiving door 61 are closed, they are locked by a locking mechanism (not shown). The syringe side door 16, the vial side door 27, the infusion side door 34, and the infusion receiving door 61 are unlocked only when the user presses the button 90. However, when it becomes possible to unlock any of the doors to open them, the control unit 140 described later invalidates the user operation on the button 90 corresponding to the door that is closed and locked. As a result, the control unit 140 maintains the doors other than the unlocked door in a closed and locked state.

[0035] In addition, the control unit 140 will not release the lock even if the button 90 corresponding to the door of the syringe shelf 10, the vial shelf 20, the infusion shelf 30, or the infusion receiving shelf 60 that is being accessed by the first transporting unit 110 or the second transporting unit 120 described below is pressed.

[0036] Furthermore, light emitting members (not shown) (e.g., LEDs; Light Emitting Diodes) may be provided corresponding to each of the syringe shelf 10, the vial shelf 20, the infusion shelf 30, and the infusion receiving shelf 60. The control unit 140 may light up the light emitting members corresponding to the shelves accessed by the first transport unit 110 or the second transport unit 120. In this case, a locking mechanism for each door may not necessarily be provided.

[0037] [Overview of the internal configuration of the co-infusion device] Fig. 2 is a perspective view showing an example of a schematic internal configuration of the co-infusion device 1 when viewed from the front (near side). Fig. 3 is a perspective view showing an example of a schematic internal configuration of the co-infusion device 1 when viewed from the rear (rear direction).

[0038] As shown in Figures 2 and 3, the co-infusion device 1 includes the above-mentioned syringe shelf 10, vial shelf 20, infusion shelf 30, printing / inspection unit 50, infusion receiving shelf 60, and trash can section 70, as well as a co-infusion unit 40, a first conveying section 110, a second conveying section 120, and an air purifying section 130.

[0039] The mixing unit 40 functions as a mixing section that mixes and injects a medicine (powdered medicine or liquid medicine) contained in a vial 502 into an infusion contained in an infusion container 503. In this embodiment, the mixing unit 40 is located between the syringe shelf 10 and the vial shelf 20 and the infusion shelf 30 and the infusion receiving shelf 60.

[0040] The mixed injection unit 40 functions as an injection unit that injects the liquid medicine contained in the vial 502 or the infusion liquid in which the powdered medicine is dissolved contained in the vial 502 into the infusion container 503. The mixed injection unit 40 functions as an injection unit that injects the infusion liquid contained in the infusion container 503 into the vial 502 in which the powdered medicine is contained. The mixed injection unit 40 also functions as an extraction unit that extracts the infusion liquid from the infusion container 503. The mixed injection unit 40 functions as an extraction unit that extracts the liquid medicine or the infusion liquid in which the powdered medicine is dissolved from the vial 502.

[0041] The first transport unit 110 transports the syringe 501 indicated in the preparation / administration data from the syringe shelf 10 to the mixed injection unit 40, or transports the vial 502 containing the drug indicated in the preparation / administration data from the vial shelf 20 to the mixed injection unit 40. When the preparation / administration data is input, the first transport unit 110 transports the syringe 501 stored on the syringe shelf 10 and the vial 502 stored on the vial shelf 20 to the mixed injection unit 40. In this embodiment, the first transport unit 110 grasps the upper part of the body of the syringe 501 stored on the syringe shelf 10 and delivers the syringe 501 to the mixed injection unit 40. Similarly, the first transport unit 110 grasps the neck of the vial 502 stored on the vial shelf 20 and delivers the vial 502 to the mixed injection unit 40.

[0042] In addition, the first transport unit 110 transports the syringe 501 stored in the syringe shelf 10 to a cap attachment / detachment unit (not shown) before transporting the syringe 501 to the mixed injection unit 40. As a result, the first transport unit 110 can remove the needle cap attached to the needle of the syringe 501, and transport the syringe 501 with the needle cap removed to the mixed injection unit 40. In addition, the first transport unit 110 transports the syringe 501 and the vial 502 after the mixed injection process (the syringe 501 and the vial 502 that are no longer needed) to the trash box unit 70. However, depending on the type of the vial 502, the first transport unit 110 may not need to transport the syringe 501 to the trash box unit 70.

[0043] The first transport unit 110 is a transport unit that transports the syringe 501 and the vial 502 and is shared by both the syringe 501 and the vial 502, but is not limited thereto. A transport unit dedicated to transporting the syringe 501 and a transport unit dedicated to transporting the vial 502 may be provided separately.

[0044] The second transport unit 120 transports the infusion container 503 indicated in the preparation and administration data between the infusion shelf 30, the mixing unit 40, the printing and inspection unit 50, and the infusion receiving shelf 60.

[0045] The second transport unit 120 transports the infusion container 503 to the mixing unit 40. When the preparation / administration data is input, the second transport unit 120 transports the infusion container 503 stored in the infusion shelf 30 to the mixing unit 40. In this embodiment, the second transport unit 120 picks up the body of the infusion container 503 stored in the infusion shelf 30 and delivers it to the mixing unit 40.

[0046] In addition, the second transport unit 120 transports the infusion container 503 between the mixing unit 40 and the printing and inspection unit 50. In this embodiment, for example, the second transport unit 120 picks up the body of the infusion container 503 after drug injection and transports it to the printing and inspection unit 50. In addition, the second transport unit 120 delivers the infusion container 503 to which the second label or the unsuitable information label has been affixed by the printing and inspection unit 50 to the infusion receiving shelf 60.

[0047] The air purifying unit 130 purifies and exhausts the air inside the co-infusion device 1. In this embodiment, it is provided at the top of the co-infusion device 1. The air purified by the air purifying unit 130 flows from the top to the bottom of the co-infusion device 1. The air purifying unit 130 has, for example, a HEPA (High Efficiency Particulate Air) filter.

[0048] The arrangement of each member in the co-infusion device 1 is not limited to the arrangement described above. In the present embodiment, the syringe shelf 10, the vial shelf 20, and the infusion shelf 30 are each provided with multiple stages, but each may be provided with one stage. In the present embodiment, the infusion receiving shelf 60 is provided with one stage, but each may be provided with multiple stages. In addition, the syringe side door 16 and / or the vial side door 27 may be provided on the side of the co-infusion device 1 (FIG. 2, right side of the paper). In this case, multiple syringes 501 or multiple vials 502 can be filled from the side of the co-infusion device 1. In addition, when the infusion shelf 30 has the same configuration as the syringe shelf 10 and the vial shelf 20, the infusion side door 34 may be provided on the side of the co-infusion device 1 (FIG. 2, left side of the paper).

[0049] [Other configurations] Fig. 4 is a block diagram showing an example of the overall configuration of the co-infusion device 1. As shown in Fig. 4, the co-infusion device 1 includes a control unit 140 and a storage unit 200. Note that Fig. 4 shows only the main hardware configuration that can be controlled by the control unit 140 among the hardware configurations included in the co-infusion device 1.

[0050] The control unit 140 comprehensively controls the operation of the co-infusion apparatus 1 based on the preparation and administration data. The control unit 140 includes, for example, a syringe transport control unit 141, a vial transport control unit 142, a first transport control unit 143, a mixed injection unit control unit 144, and a second transport control unit 145. The control unit 140 includes, for example, a pushing control unit 147, a shutter control unit 148, a printing / inspection unit control unit 149, a touch panel control unit 150, a first determination unit 151, a second determination unit 152, and a discrimination unit 153.

[0051] The syringe transport control unit 141 controls the operation of members related to the transport of the syringe 501 in the syringe shelf 10. The vial transport control unit 142 controls the operation of members related to the transport of the vial 502 in the vial shelf 20. The mixed injection unit control unit 144 controls the operation of members provided in the mixed injection unit 40.

[0052] The first transport control unit 143 controls the operation of the members included in the first transport unit 110. The first transport control unit 143 controls the movement of the first transport unit 110 between, for example, the syringe shelf 10, the vial shelf 20, the mixed injection unit 40, the wastebasket unit 70, and the cap attachment / detachment unit (not shown). The second transport control unit 145 controls the operation of the members included in the second transport unit 120. The second transport control unit 145 controls the movement of the second transport unit 120 between, for example, the infusion shelf 30, the mixed injection unit 40, the printing / inspection unit 50, and the infusion receiving shelf 60.

[0053] The pushing control unit 147 controls the operation of members related to the transportation of the infusion container 503 in the infusion shelf 30. The shutter control unit 148 controls the movement of the shutter 37 (see FIG. 3). The printing and inspection unit control unit 149 controls the operation of members provided in the printing and inspection unit 50. The touch panel control unit 150 controls the touch panel 80. The first judgment unit 151, the second judgment unit 152, and the discrimination unit 153 will be described later.

[0054] The storage unit 200 also stores data for the control unit 140 to perform various processes (e.g., co-infusion process). The storage unit 200 stores, for example, preparation and administration data. The information stored in the storage unit 200 may be stored in an external storage device of the co-infusion device 1.

[0055] The co-infusion device 1 also includes a capping / removing unit that attaches and removes the needle cap of the syringe 501. The syringe 501 loaded in the syringe shelf 10 has a needle cap attached to the needle of the syringe 501. The capping / removing unit removes the needle cap attached to the needle of the syringe 501 before being transported to the co-infusion unit 40, and holds the needle cap. When the first transport unit 110 inserts the syringe 501 into the capping / removing unit, the capping / removing unit clamps the needle cap attached to the needle of the syringe 501, thereby removing the needle cap from the syringe 501.

[0056] The capping / removing section also attaches the needle cap it is holding to the needle of the syringe 501 used in the mixed injection unit 40. The capping / removing section releases the clamping of the needle cap when the first transport section 110 inserts the syringe 501 into the capping / removing section and the needle of the syringe is inserted into the needle cap. This causes the capping / removing section to attach the needle cap to the needle of the syringe 501.

[0057] The capping / removing section may include a pair of clamping sections (claw sections) that clamp the needle of the syringe 501. The pair of clamping sections clamp the needle of the syringe 501 when the first transporting section 110 inserts the syringe 501 into the capping / removing section. The pair of clamping sections are provided at positions facing the needle cap holding position in the capping / removing section. The first transporting section 110 further moves the syringe 501 to the needle cap holding position with the pair of clamping sections clamping the needle of the syringe 501.

[0058] By clamping the needle of the syringe 501 with a pair of clamping parts, the needle of the syringe 501 can be oriented in the direction of the holding position of the needle cap. Therefore, even if the needle of the syringe 501 is bent by the mixed injection operation, the needle of the syringe 501 can be inserted into the needle cap.

[0059] [Specific configuration of the mixing unit] Fig. 5 is a perspective view showing an example of the configuration of the co-infusion unit 40. As shown in Fig. 5, the co-infusion unit 40 includes a syringe holder 41, a vial holder 42, and an infusion container holder 43.

[0060] The syringe holding section 41 is a member that holds the syringe 501 transported by the first transport section 110.

[0061] In the mixed injection unit 40, the syringe 501 is used as a syringe for extracting an infusion contained in an infusion container 503, or as a syringe for injecting a liquid medicine or infusion into the infusion container 503. The syringe 501 is also used as a syringe for extracting a liquid medicine or infusion contained in a vial 502, or as a syringe for injecting an infusion into the vial 502. The infusion extracted from the vial 502 and the infusion injected into the infusion container 503 are infusions in which powdered medicine has been dissolved. The infusion injected into the vial 502 is infusion contained in the infusion container 503 (infusion in which powdered medicine has not been dissolved) or infusion in which powdered medicine has been dissolved.

[0062] The syringe 501 includes a syringe 5011, a needle 5014, and a plunger 5015. The plunger 5015 is a pusher that moves in and out of the syringe 5011. The plunger 5015 moves in and out of the syringe 5011, thereby drawing a medicine or the like into the syringe 5011 and discharging the medicine or the like from the syringe 5011. The syringe 5011 includes a needle-side end 5012 to which the needle 5014 is attached, and a flange 5013 that is an end opposite to the needle-side end 5012 and is an end on the side where the plunger 5015 moves in and out.

[0063] Syringe holding section 41 includes moving section 411, position fixing section 412, first syringe holding section 416, and plunger holding section 417. Note that in this specification, the member described as holding the object is merely an example, and the member may be any member capable of holding the object.

[0064] The moving parts 411 are a pair of moving parts that move between a position close to each other and a position separated from each other. When the moving parts 411 are located at a position close to each other, they clamp the needle 5014. The moving parts 411 clamp the needle 5014 and position the tip of the needle 5014 at a fixed position. This allows even a bent needle 5014 to be punctured into a desired position (correct position) of a stopper provided on the infusion container 503 during a mixed injection operation.

[0065] Fig. 6 is a schematic diagram showing an example of the configuration of the moving part 411. Reference numerals 1001 and 1002 in Fig. 6 are plan views of the moving part 411. Reference numeral 1003 in Fig. 6 is a side view of the moving part 411. Fig. 6 shows a state in which the moving part 411 holds a needle 5014.

[0066] 6, the moving part 411 includes a first moving part 411A and a second moving part 411B. The first moving part 411A and the second moving part 411B each have a clamping part Pr11 (enclosed in a dotted line frame) that clamps the needle 5014 at a position close to each other, and a non-clamping part Pr12 other than the clamping part Pr11. The clamping part Pr11 has an insulating member 4111, and at least a part of the non-clamping part Pr12 has a conductive member 4112.

[0067] As shown by reference numeral 1001 in FIG. 6, the insulating member 4111 may be provided in a region where the first moving part 411A and the second moving part 411B face each other in a plan view. In this embodiment, the first moving part 411A and the second moving part 411B are made of a conductive member 4112, and the insulating member 4111 is provided in a region where the first moving part 411A and the second moving part 411B face each other in a plan view. The insulating member 4111 may be provided by, for example, white alumina spraying. As shown by reference numeral 1002 in FIG. 6, the insulating member 4111 may be provided only in the sandwiching part Pr11 of the first moving part 411A and the second moving part 411B (or only in the sandwiching part Pr11 and its surrounding area) in a plan view.

[0068] The insulating member 4111 may not be provided on the entire surface of the first moving part 411A facing the second moving part 411B and the entire surface of the second moving part 411B facing the first moving part 411A. These surfaces may include both the insulating member 4111 and the conductive member 4112. It is sufficient that at least the clamping part Pr11 is made of the insulating member 4111.

[0069] In this embodiment, as shown by reference numeral 1003 in Fig. 6, the first moving part 411A and the second moving part 411B form an L-shaped gap when they are close to each other. In this state, a facing region Ar11 where the first moving part 411A and the second moving part 411B face each other in the up-down direction (Z-axis direction) is a part of the non-clamping part Pr12. The facing region Ar11 is not provided with an insulating member 4111, and is made of a conductive member 4112.

[0070] If liquid (liquid medicine or infusion) leaks from the syringe 501 and adheres to the needle 5014, the liquid adheres to the clamping part Pr11 when the needle 5014 is clamped by the clamping part Pr11. In addition, liquid may leak from the stopper of the vial 502 and adhere to the needle 5014, or liquid may adhere to the needle 5014 when the tip of the needle 5014 is inserted into the vial 502 or the infusion container 503. In such cases, the liquid also adheres to the clamping part Pr11 when the needle 5014 is clamped by the clamping part Pr11.

[0071] The liquid adhering to the clamping portion Pr11 moves to the surfaces of the first moving portion 411A and the second moving portion 411B, which are configured of the conductive member 4112. Therefore, when the first moving portion 411A and the second moving portion 411B are brought close to each other, the first moving portion 411A and the second moving portion 411B are electrically connected to each other via the liquid. The control portion 140 can detect the state in which the liquid is attached to the moving portion 411 by detecting this electrical connection. This allows the control portion 140 to determine that there is a high possibility that the liquid is attached to the clamping portion Pr11.

[0072] Liquid adhering to the clamping portion Pr11 is particularly likely to accumulate in the opposing region Ar11. Specifically, in the reference numeral 1003 in FIG. 6, the surfaces of the first moving portion 411A and the second moving portion 411B facing each other and on which the insulating member 4111 is provided face the vertical direction (±Z axis direction) except when the co-infusion unit 40 is rotating. On the other hand, the opposing region Ar11 does not face the vertical direction except when the co-infusion unit 40 is rotating. Therefore, liquid is more likely to accumulate in the opposing region Ar11 than in the above-mentioned mutually opposing surfaces. By configuring the opposing region Ar11 with the conductive member 4112, the control unit 140 can accurately determine that there is a high possibility that liquid is adhering to the clamping portion Pr11.

[0073] For example, the control unit 140 may determine whether liquid is attached to the moving unit 411 by passing a current through the moving unit 411 before holding the needle 5014 of the syringe 501 to be used in the next mixed injection operation after injecting liquid into the infusion container 503. If the control unit 140 determines that liquid is attached to the moving unit 411, the touch panel control unit 150 may notify the touch panel 80 that liquid is attached to the moving unit 411 or that the moving unit 411 (particularly the clamping part Pr11 and its surrounding area) should be cleaned. For example, the touch panel control unit 150 may notify the same before holding the needle 5014 of the syringe 501 to be used in the next mixed injection operation after injecting liquid into the infusion container 503.

[0074] When the moving unit 411 holds the needle 5014 of the syringe 501 to be used in the next mixed injection operation with the liquid used in the previous mixed injection operation attached to the clamping part Pr11, there is a risk that the liquid will adhere to the needle 5014. When the needle 5014 to which the liquid used in the previous mixed injection operation is attached is inserted into the vial 502 or the infusion container 503 to be used in the next mixed injection operation, the liquid used in the previous mixed injection operation will be mixed with the medicine in the vial 502 or the infusion in the infusion container 503. Such a mixture is also called contamination. As described above, the touch panel control unit 150 notifies the user of the adhesion of the liquid to the moving unit 411 when the touch panel control unit 150 detects the adhesion of the liquid to the moving unit 411, thereby reducing the possibility of contamination occurring.

[0075] In this way, when liquid is attached to the moving parts 411 and the moving parts 411 are located close to each other, the conductive members 4112 of the moving parts 411 are electrically connected through the liquid. Therefore, the co-infusion unit control part 144 can detect whether or not the liquid is attached to the moving part 411 based on the presence or absence of electrical connection.

[0076] In addition, the clamping part Pr11 has an insulating member 4111. Therefore, when the moving part 411 clamps the needle 5014 at the clamping part Pr11, the possibility of the moving part 411 being conductive via the needle 5014 can be reduced. Therefore, the possibility that the co-infusion unit control part 144 erroneously detects that liquid has adhered to the moving part 411 due to the conductivity via the needle 5014 can be reduced.

[0077] The first syringe holding portion 416 is a member that first holds the syringe 501 that the first transporting portion 110 has transported from the syringe shelf 10. The first syringe holding portion 416 holds the side of the syringe 5011 (e.g., the lower portion of the syringe 5011) inserted into the first syringe holding portion 416.

[0078] The position fixing part 412 is a member that fixes the position of the syringe 501 in the extension direction of the syringe 501 at the needle side end part 5012 and the flange 5013. In this embodiment, the relative positions of the second syringe holding part 413 and the third syringe holding part 414 that constitute the position fixing part 412 can be changed along the extension direction of the syringe 501. The second syringe holding part 413 and the third syringe holding part 414 are attached such that at least one of the second syringe holding part 413 and the third syringe holding part 414 is movable along the extension direction of the syringe 501.

[0079] In this embodiment, when the syringe 501 is held by the position fixing part 412, the second syringe holding part 413 abuts from the lower side of the needle side end part 5012, and the third syringe holding part 414 abuts from the upper side of the flange 5013. This allows the position fixing part 412 to clamp the syringe 501 along the extension direction of the syringe 501.

[0080] The plunger clamping portion 417 is a member that clamps the plunger 5015. In this embodiment, the plunger clamping portion 417 clamps the tip portion of the plunger 5015. The plunger clamping portion 417 moves in the vertical direction relative to the moving portion 411, the position fixing portion 412, and the first syringe holding portion 416, whereby the plunger 5015 can be moved relative to the syringe 5011.

[0081] The vial holder 42 is a member that holds the vial 502 (the vial 502 transported by the first transport unit 110) that contains a medicine to be injected into the infusion container 503. The vial holder 42 is also a member that holds the vial 502 that contains an infusion in which a powdered medicine is dissolved, to be injected into the infusion container 503. In this embodiment, the vial holder 42 holds the neck of the vial 502.

[0082] The infusion container holding part 43 is a member that holds the infusion container 503 (the infusion container 503 transported by the second transport part 120). In this embodiment, the infusion container holding part 43 includes an infusion clamping part 431 that clamps the neck part of the infusion container 503, and a mounting base 432 on which the infusion container 503 is placed when extracting infusion from the infusion container 503 or when injecting infusion into the infusion container 503.

[0083] 7 is a front view showing an example of a schematic configuration of the mixing unit 40, and is a diagram for explaining an example of the operation of the mixing unit 40. As shown in Figs. 5 and 7, in this embodiment, the mixing unit 40 is provided on a side wall of the infusion shelf 30. Specifically, in the mixing device 1, the mixing unit 40 is arranged so that the syringe holding part 41, the vial holding part 42, and the infusion container holding part 43 face in the direction of the syringe shelf 10 and the vial shelf 20 (+X-axis direction).

[0084] 7, the syringe holding part 41 is movable in the vertical direction. This allows the needle 5014 to pierce the vial 502 or the infusion container 503 located directly below the syringe 501 held by the syringe holding part 41.

[0085] In addition, the vial holding part 42 and the infusion container holding part 43 are movable in the front-rear direction (±Y-axis direction) of the co-infusion device 1. In this embodiment, the vial holding part 42 and the infusion container holding part 43 are attached to a base 44, and the base 44 moves in the front-rear direction of the co-infusion device 1. This allows the vial holding part 42 and the infusion container holding part 43 to move between a position indicated by reference numeral 1011 in FIG. 7 and a position indicated by reference numeral 1012 in FIG. 7. The position indicated by reference numeral 1011 in FIG. 7 is a first puncture position when the needle 5014 punctures the vial 502, and the position indicated by reference numeral 1012 in FIG. 7 is a second puncture position when the needle 5014 punctures the infusion container 503. Therefore, the needle 5014 of the syringe 501 held by the syringe holding part 41 can be pierced into the stopper 5021 of the vial 502 held by the vial holding part 42, or the stopper 5035 of the infusion container 503 held by the infusion container holding part 43. However, the syringe holding part 41, instead of the base part 44, may move in the front-rear direction of the co-infusion device 1.

[0086] 7, the co-infusion unit 40 is provided rotatably around a rotation axis Ax (Ax is the rotation axis). The rotation axis Ax is an axis extending in a direction perpendicular to the base on which the syringe holder 41, the vial holder 42, and the infusion container holder 43 are provided (±X-axis direction).

[0087] At the first puncture position indicated by reference numeral 1011 in Fig. 7, the mixing unit 40 rotates about the rotation axis Ax, thereby moving the vial 502 above the syringe 501. At the second puncture position indicated by reference numeral 1012 in Fig. 7, the mixing unit 40 rotates about the rotation axis Ax, thereby moving the infusion container 503 above the syringe 501. In these states, the mixing unit 40 moves the plunger 5015 to allow liquid to flow between the syringe 501 and the vial 502 or the infusion container 503.

[0088] <Example of mixed injection of powdered medicines> Fig. 8 is a flow chart showing an example of a process flow when powdered medicine contained in a vial 502 is mixed and injected into an infusion. As a premise of this process, the syringe 501, vial 502, and infusion container 503 used for the mixed injection are held in the mixed injection unit 40. Fig. 9 is a schematic diagram showing an example of the operation of the mixed injection unit 40 when dissolving the powdered medicine in the infusion. Figs. 10 and 11 are schematic diagrams showing an example of the operation of the mixed injection unit 40 when extracting the infusion in which the powdered medicine is dissolved from the vial 502.

[0089] As shown in FIG. 8, the mixed injection unit control unit 144 controls the syringe holding unit 41 to insert the needle 5014 of the syringe 501 into the stopper 5035 of the infusion container 503, and then extracts the infusion from the infusion container 503 (S1). The amount of infusion that the mixed injection unit control unit 144 extracts from the infusion container 503 is the amount of infusion to be extracted indicated in the above-mentioned preparation and administration data. This amount to be extracted may be set to be greater than the specified amount. If the specified amount is, for example, 5 mL, the mixed injection unit control unit 144 extracts, for example, 10 mL of infusion from the infusion container 503.

[0090] The specified amount is the amount of infusion liquid that can be injected into the vial 502, and is determined for each type of vial 502 containing powdered medicine. When the infusion liquid is injected into the vial 502, the internal pressure of the vial 502 rises. If the internal pressure continues to rise, the stopper 5021 may crack and the infusion liquid may spray out from the stopper 5021. The specified amount may be determined, for example, through experiments, etc., to an amount that does not cause cracks even if the infusion liquid or gas is not extracted from the vial 502 to create negative pressure. The memory unit 200 stores the type of the vial 502 containing the powdered medicine and the specified amount of infusion liquid that can be injected into the vial 502 in association with each other. However, the specified amount may be determined uniformly for all vials 502. The information indicating the type of the vial 502 described above is included in the preparation / administration data.

[0091] Thereafter, the mixed injection unit control section 144 removes the needle 5014 of the syringe 501 from the stopper 5035, moves the base 44, and then punctures the stopper 5021 with the needle 5014 attached to the syringe 501. Thereafter, the mixed injection unit control section 144 rotates the mixed injection unit 40 around the Ax axis until the vial 502 is positioned directly above the syringe 501.

[0092] The mixed injection unit control section 144 controls the plunger clamping section 417 to move the plunger 5015, thereby injecting a part of the infusion liquid contained in the syringe 501 into the vial 502 containing the powdered medicine (S2). The plunger clamping section 417 is an example of an injection section. This injection allows the powdered medicine to be dissolved in the infusion liquid in the vial 502.

[0093] The mixed injection unit control unit 144 injects, for example, a specified amount of the infusion liquid (for example, 5 mL out of 10 mL) into the vial 502 as a part of the infusion liquid contained in the syringe 501. In this case, the increase in the internal pressure of the vial 502 caused by the injection of the infusion liquid can be reduced. From this point of view, the mixed injection unit control unit 144 may inject less than the specified amount of the infusion liquid into the vial 502. However, injecting the specified amount of the infusion liquid into the vial 502 allows the powdered medicine to be dissolved more efficiently in the infusion liquid. Information indicating the amount of injection into the vial 502 is stored in the storage unit 200.

[0094] In this embodiment, as indicated by reference numeral 1021 in Fig. 9, the plunger clamping portion 417 injects (sprays) the infusion liquid contained in the syringe 501 into the vial 502 with the tip of the needle 5014 attached to the syringe 501 facing upward and piercing the stopper 5021. This allows the infusion liquid injected into the vial 502 to easily spread throughout the vial 502. Therefore, the powdered medicine can be efficiently dissolved in the infusion liquid.

[0095] Next, the mixed injection unit control section 144 controls the plunger clamping section 417 to move the plunger 5015, thereby extracting the infusion in which the powdered medicine is dissolved from the vial 502 into which the infusion was injected in S2 using the same syringe 501 as the syringe 501 into which the infusion was injected in S2 (S3). The plunger clamping section 417 is an example of an extracting section.

[0096] By the above-mentioned extraction, the infusion liquid in which the powdered medicine extracted in S3 is dissolved is mixed with the remaining infusion liquid of the syringe 501 that has not been injected into the vial 502. The plunger clamping unit 417 is an example of a mixing unit that mixes the remaining infusion liquid that has not been injected into the vial 502 with the infusion liquid in which the powdered medicine extracted in S3 is dissolved.

[0097] Reference numeral 1022 in Fig. 9 indicates a state in which the injection of the infusion liquid into the vial 502 by the plunger clamping part 417 is completed. While maintaining this state, the mixed injection unit control part 144 draws the infusion liquid in which the powdered medicine is dissolved, contained in the vial 502, into the syringe 501, as indicated by reference numeral 1023 in Fig. 9.

[0098] In this way, by using the syringe 501 containing the remaining infusion liquid to extract the infusion liquid in which the powdered medicine is dissolved from the vial 502 into which the infusion liquid was injected in S2, the remaining infusion liquid and the infusion liquid in which the powdered medicine is dissolved can be mixed inside the syringe 501. Since these two infusion liquids can be mixed by the operation of extracting the infusion liquid in which the powdered medicine is dissolved, efficient mixing is possible. In addition, the concentration of the powdered medicine in the remaining infusion liquid is lower than the concentration of the powdered medicine in the infusion liquid extracted from the vial 502. Therefore, by mixing the remaining infusion liquid and the infusion liquid extracted from the vial 502, the concentration of the powdered medicine in the infusion liquid in the syringe 501 after mixing is lower than the concentration of the powdered medicine in the infusion liquid extracted from the vial 502. Therefore, when the next infusion liquid is injected, the powdered medicine in the vial 502 is dissolved by the infusion liquid of low concentration, so that the powdered medicine can be dissolved efficiently.

[0099] The co-infusion unit control section 144 judges whether the processes of S2 to S4 have been executed a predetermined number of times (S5). The predetermined number of times is a value indicating a preset specified number of times -1. Information indicating the specified number of times is stored in the storage section 200. The specified number of times may be a constant value regardless of the type of powdered medicine, or may be a value set for each type of powdered medicine. The specified number of times is set to a value of 2 or more. The specified number of times may be determined, for example, through experiments, to be the number of times at which the powdered medicine contained in the vial 502 is sufficiently dissolved in the infusion liquid.

[0100] When the mixed injection unit control unit 144 determines that the processes of S2 to S4 have not been performed the predetermined number of times (NO in S5), it returns to the process of S2 and executes the processes of S2 to S4 until the predetermined number of times is reached. In the process of S2 from the second time onwards, the mixed injection unit 40 (plunger clamping unit 417) injects the infusion in which the powdered medicine is dissolved (part of the infusion mixed in S4) into the vial 502 as part of the infusion to be injected into the vial 502. As shown by reference numerals 1023 and 1024 in FIG. 9, the mixed injection unit control unit 144 injects the infusion in which the powdered medicine is dissolved, which has been drawn into the syringe 501, into the vial 502 while maintaining the needle 5014 of the syringe 501 pierced into the stopper 5021. In addition, in the process of S4 from the second time onwards, the remaining infusion in the syringe 501 is the infusion in which the powdered medicine is dissolved. In addition, the injection amount of the infusion from the second time onwards may be less than the specified amount.

[0101] When the mixed injection unit control section 144 determines that the processes of S2 to S4 have been executed a predetermined number of times (YES in S5), it injects the infusion liquid in which the powdered medicine has been dissolved, which has been extracted from the vial 502, into the vial 502 (S6).

[0102] Next, the mixing unit control section 144 rotates the mixing unit 40 to tilt the vial 502 so that the stopper 5021 faces downward from a first state to a second state facing the horizontal surface (S7). The mixing unit 40 is an example of a tilting section. In this embodiment, the mixing unit control section 144 changes the posture of the vial 502 from a first state in which the vial 502 is located directly above the syringe 501 as shown by reference numeral 1031 in FIG. 10 to a second state in which the vial 502 is tilted as shown by reference numeral 1032 in FIG. 10.

[0103] In the second state, the mixed injection unit control section 144 controls the plunger clamping section 417 to extract the infusion liquid in which the powdered medicine is dissolved from the vial 502 (S8). As a result, the infusion liquid in which the powdered medicine is dissolved extracted in S8 is mixed with the remaining infusion liquid in the syringe 501 (S9).

[0104] When the stopper 5021 faces downward, the infusion liquid in which the powdered medicine is dissolved flows toward the stopper 5021 due to its own weight. However, when the stopper 5021 of the vial 502 faces vertically downward as shown by reference numeral 1031 in Fig. 10, the infusion liquid in which the powdered medicine is dissolved adheres to the bottom 5022, and liquid pooling may occur at the bottom 5022. In particular, when the central region 5022A of the bottom 5022 protrudes inward from the corners 5022B as shown in Fig. 10, the contact area of ​​the liquid at the corners 5022B becomes large, and liquid pooling is likely to occur at the bottom 5022.

[0105] When the infusion liquid with the powdered medicine dissolved therein is extracted from the vial 502, by tilting the vial 502 so that the vial 502 is in a second state which is closer to the horizontal plane than the first state, the infusion liquid with the powdered medicine dissolved therein adhering to the bottom 5022 is more likely to flow toward the stopper 5021 due to its own weight.

[0106] Information indicating the inclination angle when the second state is set is stored in the storage unit 200. The inclination angle may be a constant value regardless of the type of powdered medicine, or may be a value set for each type of powdered medicine. The inclination angle may be determined, for example, through an experiment, taking into consideration the ease of flow of the infusion solution in which the powdered medicine is dissolved. The same applies to the inclination angle when the third state is set, which will be described later.

[0107] In S8, the mixed injection unit control unit 144 judges whether a predetermined time has elapsed after extracting a predetermined amount of the infusion in which the powdered medicine is dissolved from the vial 502 (S10). The mixed injection unit control unit 144 waits until the predetermined time has elapsed (if NO in S10). When the mixed injection unit control unit 144 judges that the predetermined time has elapsed (if YES in S10), it controls the plunger clamping unit 417 to extract the infusion in which the powdered medicine is dissolved again from the vial 502 (S12). This allows the infusion in which the powdered medicine is dissolved to be extracted from the vial 502 by a predetermined extraction amount. The mixed injection unit control unit 144 does not perform an operation of injecting the gas in the syringe 501 into the vial 502 from the time when the mixed injection unit control unit 144 extracts the infusion in which the powdered medicine is dissolved again after extracting a predetermined amount of the infusion in which the powdered medicine is dissolved from the vial 502.

[0108] When an infusion is injected into the vial 502, bubbles may form depending on the type of powdered medicine. In order to extract the infusion in which the powdered medicine has dissolved from the vial 502, it is better to turn the bubbles into a liquid. This is because it is difficult to extract the infusion if it remains a foam.

[0109] In a state where bubbles are generated as shown by reference numeral 1041 in FIG. 11, the mixed injection unit control section 144 performs a process of extracting a predetermined amount of the infusion in which the powdered medicine has been dissolved (the process of S8 shown in FIG. 8), thereby extracting only the infusion as shown by reference numeral 1042 in FIG. 11. Then, by extracting only the infusion from the vial 502, the inside of the vial 502 can be negatively pressurized. This negative pressure can eliminate bubbles generated by the injection of the infusion and turn it into a liquid as shown by reference numeral 1043 in FIG. 11. Therefore, the infusion that has turned from a foam to a liquid can be extracted earlier than waiting for the bubbles to disappear naturally before extracting the infusion.

[0110] The predetermined amount is set to an amount less than the amount of infusion injected into the vial 502. This is to prevent the infusion that has turned into foam from being extracted. Information indicating the predetermined amount and information indicating the predetermined time are stored in the memory unit 200. The predetermined amount and the predetermined time may be constant values ​​regardless of the type of powdered medicine, or may be values ​​set for each type of powdered medicine. The predetermined amount may be determined, for example, through experiments, etc., in consideration of the proportion of the injected infusion that turns into foam. The predetermined time may be determined, for example, through experiments, etc., in consideration of the time it takes for foam to turn into liquid.

[0111] As shown by reference numeral 1044 in Fig. 11, at least the position of the tip of the needle 5014 when withdrawing the infusion may be the same as the stopper 5021. It is sufficient that only the opening of the tip of the needle 5014 is present inside the vial 502 from the stopper 5021. This makes it possible to withdraw most of the infusion in which the powdered medicine has been dissolved from the vial 502. The amount of puncture of the stopper 5021 may be determined based on the type of vial 502, the type of syringe 501, and the type of needle 5014 used for the mixed injection.

[0112] Prior to S12, the mixing unit control section 144 rotates the mixing unit 40 to tilt the vial 502 so that the stopper 5021 is in a third state in which it faces downward more than in the second state (S11).

[0113] In the second state, there is a risk that the infusion liquid containing dissolved powdered medicine will accumulate in shoulder portion 5023 (see reference numeral 1032 in FIG. 10) of vial 502. Therefore, if the infusion liquid is withdrawn while in the second state, there is a risk that the infusion liquid will remain in shoulder portion 5023. As described above, by changing the posture of vial 502 from the second state to the third state, the infusion liquid that has accumulated in shoulder portion 5023 due to the second state will easily flow toward stopper 5021 due to its own weight.

[0114] In this embodiment, the mixed injection unit control section 144 changes the attitude of the vial 502 from the second state to the first state. This makes it easier for most of the infusion liquid retained in the shoulder section 5023 to flow to the stopper 5021.

[0115] (Modification) In the initial process of S2, the mixing unit control section 144 may control the operation of the mixing unit 40 as shown in Fig. 12. After inserting the needle 5014 into the vial 502, the mixing unit control section 144 may inject the infusion in the syringe 501 into the vial 502 while rotating the mixing unit 40. Then, the mixing unit control section 144 rotates the mixing unit 40 until the vial 502 is positioned directly above the syringe 501. By performing such operation control, the time required for mixing can be shortened.

[0116] The mixing unit control section 144 may rotate the mixing unit 40 during or after injection of the infusion liquid into the vial 502. If the position of the syringe 501 directly above the vial 502 is defined as 0°, the mixing unit control section 144 may rotate the mixing unit 40 within a range of 0° to 180°. The mixing unit control section 144 may also rotate the mixing unit 40 within a range of 135° to 225°.

[0117] After the process of S12, the mixed injection unit control section 144 controls the syringe holding section 41 to remove the needle 5014 from the vial 502. The needle 5014 is removed after the syringe 501 is positioned directly above the vial 502, for example.

[0118] Before the removal operation of the needle 5014, the mixed injection unit control unit 144 may control the plunger clamping unit 417 to pull the plunger 5015 in a state in which the tip of the needle 5014 is positioned in the gas phase in the vial 502. Thereafter, the mixed injection unit control unit 144 may control the syringe holding unit 41 to remove the needle 5014 from the vial 502.

[0119] By pulling the plunger 5015 in the above state, the gas in the vial 502 can be moved into the syringe 501. This movement can create negative pressure in the vial 502 and the syringe 501. Since the inside of the syringe 501 is under negative pressure, the possibility of the infusion dripping from the needle 5014 can be reduced even when the needle 5014 is removed.

[0120] Furthermore, when extracting from vial 502 an amount of infusion liquid smaller than the amount of infusion liquid injected into vial 502 to dissolve the powdered medicine (also called fractional extraction), the inside of vial 502 is under positive pressure after the infusion liquid is extracted. The above operation can reduce the internal pressure of vial 502, thereby reducing the possibility of the infusion liquid spraying out of vial 502. The same applies when liquid medicine is extracted from vial 502.

[0121] The mixing unit control section 144 may not perform the processes from S5 onward. In this case, the mixing unit control section 144 determines in S5 whether the processes from S2 to S4 have been performed a specified number of times. If the processes from S2 to S4 have been performed a specified number of times, the mixing unit control section 144 ends this flow.

[0122] The timing for changing the attitude of the vial 502 from the first state to the second state may be, for example, after the infusion liquid is first injected into the vial 502, or after the infusion liquid is subsequently injected into the vial 502. Also, it may be before the process of S6 (before the infusion liquid is finally injected into the vial 502). The timing for changing the attitude of the vial 502 from the second state to the third state may be, for example, before the process of S3, or before the process of S8.

[0123] The mixing unit control unit 144 may not perform the process of tilting the vial 502 (the processes of S7 and S11). The mixing unit control unit 144 may not perform the process of extracting the remaining infusion from the vial 502 after a predetermined time has elapsed since a predetermined amount of infusion is injected into the vial 502 (the processes of S8, S10, and S12). The mixing unit control unit 144 may perform the processes of S8, S10, and S12 only for powdered medicine that is likely to foam when the infusion is injected into the vial 502, for example. Information indicating whether the processes of S8, S10, and S12 are required may be stored in the storage unit 200 in association with information indicating the type of medicine.

[0124] In the process of S8, the co-infusion unit control section 144 may extract the gas in the vial 502 instead of extracting a predetermined amount of the infusion liquid from the vial 502. In this case, the co-infusion unit control section 144 may extract the infusion liquid from the vial 502 after a predetermined time has elapsed after extracting the gas in the vial 502. Even in this case, the inside of the vial 502 can be negatively pressurized, so that the generated bubbles can be eliminated and turned into liquid.

[0125] Although in S1, more than the specified amount of infusion is extracted from the infusion container 503, this is not limiting, and more than the specified amount of infusion may be contained in the syringe 501 in advance. In this case, the mixed injection unit control unit 144 does not need to perform the process of S1.

[0126] In this embodiment, an operation of extracting the infusion from the vial 502 is performed, and the extracted infusion is mixed with the remaining infusion in the syringe 501. However, the extracting operation and the mixing operation may be performed independently. For example, the mixed injection unit control unit 144 may hold a syringe 501 different from the syringe 501 containing the remaining infusion in the mixed injection unit 40, and extract the infusion from the vial 502 using the syringe 501. The control unit 140 may control a mechanism for holding these two syringes 501, and mix the infusions held in one syringe 501 and the infusion held in the other syringe 501 by injecting them into one container. The mechanism for holding the two syringes 501 is an example of a mixing unit.

[0127] In this embodiment, the above two operations and the operation of injecting a part of the infusion liquid in the syringe 501 into the vial 502 are performed by the co-infusion unit 40. However, these operations may be realized by different members. That is, the co-infusion device 1 may include an injecting section that performs the above-mentioned injection operation, an extracting section that performs the above-mentioned extraction operation, and a mixing section that performs the above-mentioned mixing operation. The co-infusion unit control section 144 may function as an operation control section that performs these operations in this order multiple times.

[0128] In this embodiment, the above three operations are executed multiple times, but each may be executed once. In this case, the mixed injection unit control section 144 may only perform the processes of S2 to S4.

[0129] (summary) As described above, by injecting a part of the infusion into the vial 502, it is possible to reduce the amount of increase in the internal pressure of the vial 502. Therefore, it is possible to reduce the possibility that the infusion will gush out from the stopper 5021.

[0130] For example, the mixed injection unit control section 144 may inject the infusion liquid after removing the gas from the vial 502. Even when such control is performed, only a portion of the removed infusion liquid (e.g., 5 mL of 10 mL) is injected into the vial 502, so that the amount of gas removed from the vial 502 can be small (e.g., 5 mL). It is not necessary to remove a large amount of gas (e.g., 10 mL) from the vial 502, as is the case when the entire removed infusion liquid (e.g., 10 mL) is injected into the vial 502. Therefore, the time required for mixed injection can be shortened.

[0131] Furthermore, even if negative pressure is not applied to the inside of the vial 502 before a portion of the infusion is injected into the vial 502, the possibility of the infusion spouting out from the stopper 5021 can be reduced.

[0132] In addition, under the control of the mixing unit control unit 144, the mixing unit 40 injects a part of the infusion liquid contained in the syringe 501 into the vial 502, then extracts the infusion liquid from the vial 502 and mixes the extracted infusion liquid with the infusion liquid in the syringe 501. The mixing unit 40 first injects a part of the infusion liquid in which the powdered medicine is not dissolved into the vial 502, and then injects a part of the infusion liquid in which the remaining infusion liquid in the syringe 501 and the infusion liquid in which the powdered medicine extracted from the vial 502 is dissolved into the vial 502. As a result, as described above, the powdered medicine in the vial 502 can be dissolved with a low concentration infusion liquid, so that the powdered medicine can be dissolved efficiently.

[0133] In addition, by performing the three actions of injecting the infusion liquid into vial 502, withdrawing the infusion liquid from vial 502, and mixing the withdrawn infusion liquid with the infusion liquid in syringe 501 multiple times in this order, most of the powdered medicine in vial 502 can be collected.

[0134] <Determining the puncture position> Fig. 13 is a schematic diagram showing a cross section of the stopper 5035 (e.g., a rubber stopper) of the infusion container 503, and shows an example of the puncturing state of the needle 5014 and a through-hole (needle hole) PH formed by the puncturing of the needle 5014. Reference numeral 1051 in Fig. 13 shows the puncturing state of the needle 5014 having an inclination angle of the tip end of α1, and reference numeral 1052 shows the puncturing state of the needle 5014 having an inclination angle of the tip end of α2 (>α1).

[0135] 13, needle 5014 has, at its tip, apex (pointed end) 5141, inclined surface 5142 (also referred to as cut surface) that forms an opening, and extending portion 5143 that extends approximately parallel to the longitudinal direction of needle 5014 at a position opposite to inclined surface 5142. The inclination angle is the angle formed between a line indicating inclined surface 5142 and a line indicating extending portion 5143 in a cross section of needle 5014 when needle 5014 is cut along a plane that includes a perpendicular to inclined surface 5142 and includes the axis of needle 5014.

[0136] As shown by symbols 1051 and 1052 in FIG. 13, when the needle 5014 is inserted into the stopper 5035, even if the needle 5014 is inserted perpendicularly to the stopper 5035, the needle 5014 advances at an angle opposite to the inclined surface 5142 (toward the extension portion 5143) due to the presence of the inclined surface 5142.

[0137] In addition, the larger the inclination angle of the tip of the needle 5014, the more the moving direction (penetration direction) of the needle 5014 deviates from the direction perpendicular to the puncture surface of the plug 5035. As shown by reference numerals 1051 and 1052 in FIG. 13, the angle β2 is larger than the angle β1. The angle β1 is an angle between a perpendicular line passing through the puncture position PP on the puncture surface of the plug 5035 and the moving direction of the needle 5014 when the needle 5014 with the inclination angle of α1 is punctured. The angle β2 is an angle between a perpendicular line passing through the puncture position PP on the puncture surface of the plug 5035 and the moving direction of the needle 5014 when the needle 5014 with the inclination angle of α2 is punctured. These angles are examples of the amount of deviation from the perpendicular line passing through the puncture position PP on the puncture surface of the plug 5035.

[0138] Furthermore, as shown by reference numeral 1053 in Fig. 13, when the needle 5014 is pierced into the plug 5035 multiple times, there is a risk that the through-holes PH formed by the needle 5014 will communicate with each other. If the through-holes PH communicate with each other, there is a risk that the overall size of the through-holes PH will increase, or the plug 5035 will be scraped off. The phenomenon in which the plug 5035 is scraped off is also called coring. In order to prevent the through-holes PH from communicating with each other, it is necessary to separate the puncture positions PP, but in this case, the number of puncture positions PP will decrease, and the number of punctures will decrease.

[0139] Fig. 14 is a diagram for explaining the penetration range of the needle 5014 in the plug 5035. As described above, the traveling direction of the needle 5014 differs depending on the orientation of the inclined surface 5142, so the traveling direction of the needle 5014 from one puncture position PP can be formed radially. Therefore, as shown by the reference numerals 1061 and 1062 in Fig. 14, a penetration range PA1 through which the needle 5014 can penetrate can be formed with the puncture position PP as the center.

[0140] Consider a case where a puncture-possible position (puncture position PP) for each of a plurality of puncture operations is preset at a position other than the non-punctureable range NGA for each type of infusion container 503. In this case, various problems may occur when the co-infusion unit control section 144 controls the operation of the co-infusion unit 40 to uniformly puncture the needle 5014 at the preset puncture position PP.

[0141] For example, as shown by reference numeral 1062 in Fig. 14, there is a risk that the needle 5014 will penetrate through the side surface of the stopper 5035, or the needle 5014 will penetrate through the stopper 5035 and pierce the inner wall of the neck of the infusion container 503. There is also a risk that a through hole PH will be formed in the non-punctureable area NGA. Furthermore, there is a risk that the through holes PH will communicate with each other. Furthermore, there is a risk that the number of punctures will be reduced by defining the puncture position PP so as not to cause communication between the through holes PH.

[0142] Therefore, in order to reduce the possibility of the occurrence of the various problems described above, the control unit 140 may determine the puncture position taking into consideration the orientation of the inclined surface 5142 of the needle 5014 that punctures the stopper 5035.

[0143] In this case, instead of presetting a puncture position PP for each type of infusion container 503, a temporary puncture position TPP is predefined at a position other than the non-puncture range NGA. The temporary puncture position TPP is a position for identifying a position where the needle 5014 can puncture corresponding to each of the multiple puncture operations of the needle 5014. The multiple temporary puncture positions TPP are determined by defining a penetration range PA2 on the puncture surface of the stopper 5035, as shown by reference numeral 1064 in FIG.

[0144] 14, the penetration range PA2 is a penetration range of the needle 5014 formed when the needle 5014 is pierced once into a certain position (puncture position PP) on the puncture surface of the plug 5035. For example, the length Le1 of the penetration path (through hole PH) can be calculated from information correlating the type of the needle 5014 with the amount of deviation from a perpendicular line passing through the puncture position PP on the puncture surface of the plug 5035, and information indicating the thickness of the plug 5035.

[0145] The length Le1 of the through path is the maximum length between the punctured portion and the pierced portion when the plug 5035 is viewed in plan view of the plug 5035, of the through path formed in one direction when puncturing once. In other words, the length Le1 of the through path is not the length in the thickness direction of the plug 5035, but the length in the direction horizontal to the puncture surface of the plug 5035. The deviation amount may be the above-mentioned angles β1 and β2, or may be the inclination of the traveling direction of the needle 5014 from the perpendicular line. The deviation amount is specified for each type of needle 5014, for example, through experiments or the like.

[0146] The length Le1 of the through path may be defined, for example, by using the maximum amount of deviation among the above-mentioned amounts of deviation corresponding to each type of needle 5014. The through range PA2 is defined as a circle having the length Le1 of the through path as its diameter and centered on the provisional puncture position TPP when the puncture surface of the plug 5035 is viewed in plan.

[0147] As described above, the penetration range PA1 is set as a range centered on the puncture position PP, encompassing all directions in which the needle 5014 can move. On the other hand, the penetration range PA2 defined as above is set based on the length Le1 of the penetration path formed when the needle 5014 is punctured once into the puncture position PP. Therefore, as shown by reference numerals 1061 and 1063 in FIG. 14, the penetration range PA2 can be set smaller than the penetration range PA1.

[0148] Therefore, when the penetration range PA2 is set corresponding to the multiple puncturing operations of the needle 5014, the positions of the multiple penetration ranges PA2 can be set so that each of the penetration ranges PA2 is located in an area other than the non-puncturing area NGA within the puncturing surface of the stopper 5035. Also, the positions of the multiple penetration ranges PA2 can be set so that the penetration ranges PA2 do not overlap with each other. Then, the temporary puncturing position TPP is set at the center position (penetration center) of each of the multiple penetration ranges PA2 set in this manner.

[0149] The process for setting the temporary puncture position TPP may be performed, for example, by the control unit 140 or by a control device different from the control unit 140. Information on the temporary puncture position TPP is stored in the storage unit 200 in association with the type of the infusion container 503.

[0150] When starting a mixed injection operation for a certain drug, the control unit 140 identifies the type of needle 5014 attached to the syringe 501 and the orientation of the inclined surface 5142 of the needle 5014. The type of needle 5014 may be identified, for example, by the discrimination unit 153 (see FIG. 4) described later. The orientation of the inclined surface 5142 may be identified, for example, by the needle detection unit 160 (see FIG. 18) described later.

[0151] The control unit 140 counts the number of times the needle 5014 punctures the infusion container 503, and stores the number in the memory unit 200. The memory unit 200 also stores information regarding which temporary puncture position TPP is to be selected for which puncture operation of the needle 5014. Therefore, the control unit 140 can identify the temporary puncture position TPP corresponding to the number of punctures.

[0152] The control unit 140 determines the puncture position PP so that the extension portion 5143 faces toward the identified temporary puncture position TPP when the puncture surface of the plug 5035 is viewed in plan. Specifically, the control unit 140 determines, as the puncture position PP, a position that is a predetermined distance away from the temporary puncture position TPP in the direction in which the inclined surface 5142 of the needle 5014 faces when the needle is positioned above the temporary puncture position TPP.

[0153] The predetermined distance is set so that the punctured needle 5014 penetrates within the penetration range PA2. The predetermined distance may be set so that the punctured needle 5014 penetrates beyond the penetration range PA2. In this case, however, the predetermined distance is set so that the needle 5014 does not penetrate the adjacent penetration range PA2 or the non-puncture range NGA and does not penetrate the side surface of the stopper 5035.

[0154] The predetermined distance may be set so that the length Le11 indicated by reference numeral 1063 in Fig. 14 is shorter than the length Le12 indicated by reference numeral 1061 in Fig. 14. The length Le11 is the length between the provisional puncture position TPP and the center position CN of the needle 5014 on the surface opposite to the puncture surface of the plug 5035 when the puncture surface of the plug 5035 is seen through in a plane. The length Le12 is the length between the puncture position PP and the center position CN of the needle 5014 on the surface opposite to the puncture surface of the plug 5035 when the puncture surface of the plug 5035 is seen through in a plane.

[0155] In this way, the control unit 140 determines a position a predetermined distance away from the provisional puncture position TPP as the puncture position PP, taking into consideration the direction of the identified inclined surface 5142. As a result, as shown by reference numeral 1064 in FIG. 14, the needle 5014 punctured at the puncture position PP advances in the direction of the arrow shown in the penetration range PA2. Therefore, the co-infusion unit 40 can puncture the needle 5014 in a range that is approximately the same as the penetration range PA2, which is smaller than the penetration range PA1. Therefore, the needle 5014 can be punctured multiple times while reducing the possibility of various problems such as those described above occurring. In addition, the number of times the relatively small stopper 5035 is punctured can be increased.

[0156] Although the method for determining the puncture position for the infusion container 503 has been described above, this determination method may also be adopted as a method for determining the puncture position for the vial 502.

[0157] <Modifications of Syringe Holding Part> Reference numeral 1071 in Fig. 15 is a perspective view and a bottom view showing an example of a middle-mouth syringe 501A in which the nozzle 5017 of the syringe 5011 is of a middle-mouth type. Reference numeral 1072 in Fig. 15 is a perspective view and a bottom view showing an example of a side-mouth syringe 501B in which the nozzle 5017 of the syringe 5011 is of a side-mouth type.

[0158] 15, the center-mouth syringe 501A is a syringe in which the nozzle 5017 is provided at the center of the bottom 5018 of the syringe 5011. The side-mouth syringe 501B is a syringe in which the nozzle 5017 is provided at a position offset from the center of the bottom 5018 of the syringe 5011, as shown by reference numeral 1072 in FIG.

[0159] The capacity (thickness; outer diameter of syringe 501) of medium-mouth syringe 501A and side-mouth syringe 501B may be different from each other. For example, the capacity (thickness) of side-mouth syringe 501B may be larger than the capacity (thickness) of medium-mouth syringe 501A.

[0160] FIG. 16 is a perspective view showing an example of a syringe holding part 41A which is a modified example of the syringe holding part 41. Reference numerals 1081 and 1082 in FIG. 16 are perspective views of the syringe holding part 41A. Reference numerals 1083 and 1084 in FIG. 16 are schematic views of the syringe holding part 41A as viewed from below. Reference numerals 1081 and 1083 in FIG. 16 show a state in which a middle-mouth syringe 501A is attached to the syringe holding part 41A, and reference numerals 1082 and 1084 show a state in which a side-mouth syringe 501B is attached to the syringe holding part 41A.

[0161] Syringe holding portion 41A includes sheet metal 418. Moreover, syringe holding portion 41A includes first syringe holding portions 416A and 416B instead of first syringe holding portion 416. In Fig. 16, third syringe holding portion 414 and plunger sandwiching portion 417 are not shown.

[0162] First syringe holding portions 416A, 416B are biased in directions approaching each other so as to be able to sandwich syringe 501. Metal plate 418 is a member that determines the position of syringe 501 in the insertion direction when first syringe holding portions 416A, 416B hold syringe 501. Metal plate 418 is provided with notch 418a for determining the position of syringe 501 in the insertion direction. The insertion direction here is the direction (-X axis direction) from a position spaced apart from first syringe holding portions 416A, 416B toward first syringe holding portions 416A, 416B on a horizontal plane.

[0163] The notch 418a is formed so that the position of the cylindrical tip 5017 is the same regardless of the type of syringe 501 used in the co-infusion apparatus 1. Specifically, the notch 418a has a plurality of portions with different curvatures provided according to the type of syringe 501 used in the co-infusion apparatus 1.

[0164] In this embodiment, as indicated by reference numerals 1083 and 1084 in FIG. 16, the cutout portion 418a includes a first cutout portion 418a1 and a second cutout portion 418a2 having different curvatures.

[0165] The first cutout portion 418a1 is provided in the center of the cutout portion 418a (the portion on the far side when viewed from the insertion direction of the syringe 501). The first cutout portion 418a1 comes into contact with a part of the medium-mouth syringe 501A when the medium-mouth syringe 501A is inserted into the cutout portion 418a.

[0166] Second cutout portion 418a2 is provided in a portion other than the center portion of cutout portion 418a (a portion on the front side as viewed from the insertion direction of syringe 501). Second cutout portion 418a2 abuts against a portion of side-port syringe 501B when side-port syringe 501B is inserted into cutout portion 418a.

[0167] When the first transport section 110 holds the syringe 501 transported from the syringe shelf 10, the first syringe holding sections 416A and 416B fix the syringe 501 at a position where the syringe 501 abuts against the cutout section 418a.

[0168] 16, first syringe holding portion 416A includes first holding portion 416A1 and second holding portion 416A2. First holding portion 416A1 is a portion on the tip side of first syringe holding portion 416A, and second holding portion 416A2 is a portion of first syringe holding portion 416A on the base portion 419 side of injector holding portion 41A.

[0169] In this embodiment, as shown by reference numeral 1083 in Fig. 16, when the first syringe holding part 416A holds the middle-port syringe 501A, the first holding part 416A holds the middle-port syringe 501A between the first holding part 416A1 and the second holding part 416A2. As shown by reference numeral 1084 in Fig. 16, when the first syringe holding part 416A holds the side-port syringe 501B, the first holding part 416A1 pushes the side-port syringe 501B toward the metal plate 418.

[0170] Although not shown, the first syringe holding portion 416B also includes a first holding portion and a second holding portion. The first holding portion and the second holding portion of the first syringe holding portion 416B also sandwich the center-mouth syringe 501A and the side-mouth syringe 501B, similar to the first holding portion 416A1 and the second holding portion 416A2.

[0171] In this way, the center-port syringe 501A can be brought into contact with the first cutout portion 418a1, and the side-port syringe 501B can be brought into contact with the second cutout portion 418a2. Therefore, regardless of whether the syringe holding portion 41A holds the center-port syringe 501A or the side-port syringe 501B, the position of the nozzle 5017 (needle 5014 attached to the syringe 501) in the insertion direction can be the same.

[0172] The syringe holding part 41, not the syringe holding part 41A, may hold different types of syringes 501. In this case, the co-infusion device 1 may be provided with an adjustment mechanism for adjusting the position of the syringe 501 so that the position of the syringe 501 in the insertion direction is the same regardless of the type of syringe 501 held by the syringe holding part 41. The adjustment mechanism may be the first conveying part 110. The co-infusion device 1 may be provided with, for example, a detection part for detecting the nozzle 5017 or the needle 5014 of the syringe 501 at the same position on the horizontal plane when the syringe holding part 41 holds the syringe 501.

[0173] <Control according to needle type> Fig. 17 is a diagram showing an example of a type of needle 5014 attached to syringe 501. Fig. 17 is a schematic diagram showing an example of a tip portion of needle 5014. As shown in Fig. 17, types of needle 5014 include, for example, regular bevel 5014A and short bevel 5014B. Regular bevel 5014A and short bevel 5014B differ in the inclination angle at the tip portion and the length of the opening in the longitudinal direction of needle 5014.

[0174] The inclination angle of the tip of the regular bevel 5014A is a first angle α11 (e.g., 12°), and the inclination angle of the tip of the short bevel 5014B is a second angle α12 (e.g., 18°) that is greater than the first angle α11. The regular bevel 5014A is an example of a first needle whose inclination angle is the first angle α11, and the short bevel 5014B is an example of a second needle whose inclination angle is the second angle α12.

[0175] The mixed injection unit control section 144 may control the syringe holding section 41 to adjust the amount of the needle 5014 piercing the stopper 5021 or the stopper 5035 according to the type of the needle 5014 attached to the syringe 501. The mixed injection unit control section 144 may control the syringe holding section 41 to adjust the piercing position of the needle 5014 in the stopper 5021 or the stopper 5035 according to the type of the needle 5014 attached to the syringe 501. The syringe holding section 41 is an example of an adjustment section. This adjustment enables the mixed injection unit 40 to perform a mixed injection operation according to the type of the needle 5014 attached to the syringe 501.

[0176] The memory unit 200 stores information that associates, for example, the type of the needle 5014 with the moving distance from the position of the needle 5014 before puncturing to the position of the stopper 5021 or the stopper 5035. The co-infusion unit control unit 144 can adjust the puncturing amount according to the type of the needle 5014 (the length of the opening of the needle 5014) by referring to the information.

[0177] For example, when the type of the needle 5014 is the short bevel 5014B, the co-infusion unit control section 144 may make the puncture amount smaller than when the type of the needle 5014 is the regular bevel 5014A. As a result, whether the type is the regular bevel 5014A or the short bevel 5014B, as shown by reference numeral 1044 in FIG. 11, only the opening can be present from the stopper 5021 to the inside of the vial 502. Therefore, whether the type is the regular bevel 5014A or the short bevel 5014B, more liquid can be extracted from the vial 502.

[0178] When the type of needle 5014 is regular bevel 5014A, the process of making the puncture amount smaller than when the type of needle 5014 is short bevel 5014B may be performed when extracting the entire amount of liquid in vial 502 (also called total collection). The amount of liquid medicine or infusion with powdered medicine dissolved therein extracted from vial 502 is stored in memory unit 200.

[0179] As described above, the travel direction and penetration range of the needle 5014 in the stopper differ depending on the inclination angle and the thickness of the stopper. The co-infusion unit control unit 144 can calculate the puncture position of the needle 5014, taking into consideration the travel direction and penetration range, based on the inclination angle according to the type of needle 5014 and the thickness of the stopper. Information indicating the inclination angle is stored in the storage unit 200 for each type of needle 5014.

[0180] 4, the co-infusion device 1 includes a needle detection unit 160 (detection section) that detects the needle 5014. The control section 140 includes a discrimination section 153 that discriminates the type of the needle 5014 based on the detection result of the needle detection unit 160. This allows the co-infusion device 1 to automatically discriminate the type of the needle 5014 and perform the co-infusion operation based on the discrimination result.

[0181] The needle detection unit 160 may be provided on the way of the first transport unit 110 to the co-infusion unit 40. The needle detection unit 160 may be provided, for example, between the syringe shelf 10 and the co-infusion unit 40 in a plan view. The needle detection unit 160 may be, for example, an optical sensor having a light receiving unit that receives light reflected by the needle 5014. The optical sensor may be provided with an emission unit that emits light. Other detection units may also be realized by optical sensors. In addition, the co-infusion device 1 may be provided with an imaging unit that images the needle 5014 attached to the syringe 501 instead of the needle detection unit 160.

[0182] Fig. 18 is a diagram showing an example of the needle detection unit 160. Reference numeral 1091 in Fig. 18 is a front view of the needle detection unit 160, and reference numeral 1092 is a side view of the needle detection unit 160. In this embodiment, as shown in Fig. 18, the needle detection unit 160 includes a first needle detection section 161, a second needle detection section 162, a third needle detection section 163, and an elongated hole 164. The first needle detection section 161 includes a first light-emitting section 161a and a first light-receiving section 161b, the second needle detection section 162 includes a second light-emitting section 162a and a second light-receiving section 162b, and the third needle detection section 163 includes a third light-emitting section 163a and a third light-receiving section 163b.

[0183] The first needle detection unit 161 and the second needle detection unit 162 detect the tip of the needle 5014 when the needle 5014 is moved in the movement direction R21 by the first transport unit 110. The first needle detection unit 161 and the second needle detection unit 162 are provided so that the first light L1 emitted by the first needle detection unit 161 and the second light L2 emitted by the second needle detection unit 162 are approximately perpendicular to each other. The third needle detection unit 163 detects the tip of the needle 5014 inserted into the long hole 164 by the first transport unit 110. The needle 5014 is inserted into the needle detection unit 160 up to the detection position of the third needle detection unit 163.

[0184] The first transport unit 110 moves the needle 5014 a first distance in the pulling-out direction R11 in a state in which the needle 5014 is inserted into the long hole 164. The first distance is the distance from the detection position of the third needle detection unit 163 to a position where the first needle detection unit 161 and the second needle detection unit 162 can detect the tip of the needle 5014, which enables the type of the needle 5014 to be identified. Information indicating the first distance is stored in the memory unit 200.

[0185] In this embodiment, the discrimination unit 153 discriminates whether the needle 5014 attached to the syringe 501 is a regular bevel 5014A or a short bevel 5014B. The first transport unit 110 pulls out the needle 5014 from the long hole 164 to a position where the detection range DA of the needle 5014 shown in FIG. 17 can be detected.

[0186] Thereafter, the first transport unit 110 moves the needle 5014 a second distance in the movement direction R21. The second distance is the distance over which the needle 5014 passes through the detection ranges of the first needle detection unit 161 and the second needle detection unit 162. Information indicating the second distance is stored in the memory unit 200. The first needle detection unit 161 and the second needle detection unit 162 are provided so that a detection range is provided within a range over which the first transport unit 110 moves the needle 5014 at a constant speed.

[0187] Fig. 19 is a diagram showing an example of a state in which the needle 5014 passes through the detection ranges of the first needle detection unit 161 and the second needle detection unit 162. Reference numeral 2001 in Fig. 19 denotes the needle 5014 as viewed from the first needle detection unit 161 side when it passes through the detection ranges of the first needle detection unit 161 and the second needle detection unit 162. Reference numeral 2002 in Fig. 19 denotes the needle 5014 as viewed from the second needle detection unit 162 side when it passes through the detection ranges of the first needle detection unit 161 and the second needle detection unit 162.

[0188] As described above, the needle 5014 moves at a constant speed within the detection range. Therefore, the control unit 140 can calculate the first width W11 by multiplying the detection time of the first needle detection unit 161 by the movement speed of the needle 5014. The control unit 140 can also calculate the second width W12 by multiplying the detection time of the second needle detection unit 162 by the movement speed of the needle 5014.

[0189] Consider a case where first needle detection unit 161 and second needle detection unit 162 detect needle 5014 at detection position DP1 of needle 5014 shown in Fig. 17. In this case, for regular bevel 5014A, first needle detection unit 161 and second needle detection unit 162 detect regular bevel 5014A at a position that includes inclined surface 5142. For short bevel 5014B, first needle detection unit 161 and second needle detection unit 162 detect short bevel 5014B at a position that does not include inclined surface 5142.

[0190] The position not including the inclined surface 5142 is a position where the regular bevel 5014A and the short bevel 5014B have a common outer diameter, and is a position where the first width W11 and the second width W12 are maximum. Therefore, at least one of the first width W11 and the second width W12 of the regular bevel 5014A is smaller than the maximum value (the outer diameter of the syringe 501 at a position not including the inclined surface 5142), while the first width W11 and the second width W12 of the short bevel 5014B are maximum values.

[0191] Therefore, in this case, when at least one of the first width W11 and the second width W12 is less than the maximum value, the discrimination unit 153 discriminates that the needle 5014 is a regular bevel 5014A. When both the first width W11 and the second width W12 are at their maximum values, the discrimination unit 153 discriminates that the needle 5014 is a short bevel 5014B. The threshold value does not have to be the maximum value, and may be a value less than the maximum value, as long as it is a value that can discriminate between the two types of needles 5014.

[0192] On the other hand, consider a case where the first needle detection unit 161 and the second needle detection unit 162 detect the needle 5014 at a detection position DP2 of the needle 5014 shown in Fig. 17. In this case, the discrimination unit 153 may discriminate the type of the needle 5014 by comparing the first width W11 and the second width W12 with a threshold value corresponding to the identified orientation of the inclined surface 5142 of the needle 5014.

[0193] Fig. 20 is a schematic diagram for explaining an example of the projection width of the needle 5014 detected when the needle 5014 moves at times T1 to T3. Reference numerals 2011 and 2012 in Fig. 20 are schematic diagrams for explaining an example of the projection width of the regular bevel 5014A. Reference numerals 2013 and 2014 in Fig. 20 are schematic diagrams for explaining the projection width of the short bevel 5014B. The projection width is formed at the time when the needle 5014 is detected.

[0194] 20, whether the needle 5014 is regular bevel 5014A or short bevel 5014B, the detection time of the needle 5014 by the first needle detection unit 161 and the second needle detection unit 162 differs depending on the orientation of the inclined surface 5142. Also, even if the orientation of the inclined surface 5142 is the same, the detection time of the needle 5014 by the first needle detection unit 161 and the second needle detection unit 162 differs depending on whether the needle 5014 is regular bevel 5014A or short bevel 5014B.

[0195] Therefore, the control unit 140 can identify the orientation of the inclined surface 5142 based on the detection times of the needle 5014 by the first needle detection unit 161 and the second needle detection unit 162. Then, the discrimination unit 153 compares a threshold value corresponding to the identified orientation of the inclined surface 5142 with the first width W11 calculated based on the detection result of the first needle detection unit 161 or the second width W12 calculated based on the detection result of the second needle detection unit 162. In this way, the discrimination unit 153 discriminates whether the needle 5014 is a regular bevel 5014A or a short bevel 5014B.

[0196] As the threshold value, a threshold value for first needle detection unit 161 and a threshold value for second needle detection unit 162 are stored in storage unit 200. The threshold value may be set, for example, through an experiment or the like, so that it is possible to determine whether needle 5014 is regular bevel 5014A or short bevel 5014B.

[0197] Furthermore, the discrimination unit 153 may discriminate whether the needle 5014 is the regular bevel 5014A or the short bevel 5014B by comparing the sum of the first width W11 and the second width W12 with a threshold value. Regardless of the direction of the inclined surface 5142, the difference in the sum between the regular bevel 5014A and the short bevel 5014B is greater than the difference between the first widths W11 or the difference between the second widths W12. Therefore, the discrimination unit 153 can discriminate whether the needle 5014 is the regular bevel 5014A or the short bevel 5014B even without taking into account the direction of the inclined surface 5142.

[0198] In the above, the co-infusion unit control unit 144 adjusts the puncture amount or puncture position of the needle 5014 in the stopper 5021 or 5035 based on the discrimination result of the discrimination unit 153. Without being limited to this, the touch panel 80 may receive input of the type of the needle 5014 attached to the syringe 501. In this case, the co-infusion unit control unit 144 may adjust the puncture amount or puncture position of the needle 5014 in the stopper 5021 or 5035 according to the input type of the needle 5014.

[0199] The type of needle 5014 may be input when the syringe 501 is filled. In this case, the control unit 140 may store in the memory unit 200 information for identifying the instrument holding unit 11, information indicating the type of the syringe 501 held in the instrument holding unit 11, and information indicating the type of the needle 5014 attached to the syringe 501 in association with each other. The type of needle 5014 may also be input before the mixed injection operation by the mixed injection unit 40.

[0200] In addition, in the above, regular bevel 5014A and short bevel 5014B are given as examples of types of needle 5014, but this is not limited thereto, and the type of needle 5014 may be determined by the inclination angle at the tip of needle 5014 or the length of the opening in the longitudinal direction of needle 5014.

[0201] <Example 1 of mixed injection using the same syringe> When the same kind of drug is used in successive mixed injection operations, the same syringe 501 may be reused. Also, when the same kind of drug is used in successive mixed injection operations that have the same concentration when dissolved in an infusion, the same syringe 501 may be reused. In this case, the number of syringes 501 used can be reduced, and therefore the cost required for mixed injection can be reduced.

[0202] The needle 5014 is preset with an upper limit number of times that it can puncture the vial 502 and the infusion container 503. Information indicating the upper limit number of times is stored in the storage unit 200. The upper limit number of times may be a constant value regardless of the type of needle 5014, or may be a value set for each type of needle 5014.

[0203] The mixing unit control unit 144 determines the order of mixing so that mixing operations using the same type of medicine are performed consecutively based on the prescription data. The mixing unit control unit 144 specifies the number of puncturing operations in one mixing operation based on the type of medicine used for mixing, etc. For example, in the case of a powdered medicine, the stopper 5035 is punctured at least twice in one mixing operation. The number of puncturing operations in one mixing operation is the total value of the number of puncturing operations into the stopper 5021 and the number of puncturing operations into the stopper 5035. Information indicating the number of puncturing operations in one mixing operation for each type of medicine may be stored in the storage unit 200.

[0204] The mixing unit control unit 144 calculates the remaining number of punctures at the end of a mixing operation by subtracting the cumulative number of punctures up to the end of a mixing operation from the upper limit number of punctures. When the mixing unit control unit 144 determines that the number of punctures in the next mixing operation will exceed the remaining number of punctures, it controls the mixing unit 40 to perform the mixing operation continuously without changing the syringe 501 up to the previous operation. This allows the same syringe 501 to be reused and reduces the possibility of the mixing operation being interrupted due to exceeding the upper limit number of punctures.

[0205] <Example 2 of mixed injection using the same syringe> When the same syringe 501 is used continuously, the co-infusion unit control section 144 may control the operation as shown in Fig. 21. Fig. 21 is a diagram showing an example of the co-infusion operation when the same syringe 501 is used continuously. Reference numeral 2021 in Fig. 21 shows an example of a co-infusion operation, and reference numeral 2022 in Fig. 21 shows an example of the co-infusion operation the next time. In this co-infusion operation, an infusion container 503 (e.g., commonly known as a plastic bottle) that does not easily lose its shape is used.

[0206] As shown by reference numeral 2021 in FIG. 21, in a certain mixed injection operation, the mixed injection unit control unit 144 controls the mixed injection unit 40 to pierce the needle 5014 of the syringe 501 into the stopper 5021 of the vial 502 and extract the liquid medicine (or the infusion in which the powdered medicine is dissolved). After that, the mixed injection unit control unit 144 injects the extracted liquid medicine into the infusion container 503, and then vibrates the plunger 5015 up and down (flush operation). After that, the mixed injection unit control unit 144 extracts gas from the infusion container 503. For example, the amount of gas equivalent to the amount of the liquid medicine injected into the infusion container 503 is extracted. This allows the inside of the infusion container 503 to be negatively pressurized.

[0207] 21, in the next mixed injection operation, the mixed injection unit control section 144 pulls the plunger 5015 before puncturing the needle 5014 into the vial 502. This draws the liquid medicine near the opening of the needle 5014 into the syringe 501.

[0208] Thereafter, in state ST2, the co-injection unit control section 144 pushes out the plunger 5015 to discharge the gas in the syringe 501 until a predetermined amount (for example, 1 mL) is reached. In order to avoid positive pressure in the vial 502, it is better not to inject gas into the vial 502, but if all the gas in the syringe 501 is discharged, there is a risk that the liquid medicine in the syringe 501 will spray out. Therefore, a small amount of gas is left in the syringe 501 so that the liquid medicine in the syringe 501 will not spray out and the vial 502 will not be positively pressurized as much as possible.

[0209] Thereafter, in state ST3, the mixed injection unit control unit 144 pierces the stopper 5021 with the needle 5014, discharges the remaining gas in the syringe 501 into the vial 502, and then extracts the liquid medicine in the vial 502. Since the amount of remaining gas is small, the amount of increase in the internal pressure of the vial can be reduced. Thereafter, the mixed injection unit control unit 144 injects the extracted liquid medicine into the infusion container 503.

[0210] When liquid medicine is extracted from vial 502 while gas is contained in syringe 501, the expansion of the gas may cause the amount of plunger 5015 pulled to not match the amount of liquid medicine that can be extracted according to the amount of the plunger pulled. This may result in a decrease in the accuracy of the amount of extracted liquid medicine. In addition, the amount of liquid medicine extracted may be reduced by the amount of gas in syringe 501. As shown by reference numeral 2022 in FIG. 21, in the next mixed injection operation, the gas is discharged from syringe 501 into vial 502 before the liquid medicine is contained in syringe 501, thereby reducing the possibility of the above-mentioned problems occurring.

[0211] [Specific configuration of syringe shelf] Fig. 22 is a perspective view showing an example of the overall configuration of the syringe shelf 10 and the vial shelf 20. Reference numeral 2031 in Fig. 23 is a diagram showing an example of the configuration of one syringe shelf 10 and one vial shelf 20 when viewed from the first transporting section 110 side. Reference numeral 2032 in Fig. 23 is a diagram for explaining the vial shelf 20.

[0212] As shown in Fig. 22, the syringe shelf 10 comprises a plurality of instrument holding sections 11, an instrument transport section 12, an object detection section 13, a syringe detection section 14, a needle detection section 15, and a syringe detection section 17. Note that an instrument holding section 11 is also attached to the attachment section 1211 of the instrument transport section 12 shown in Fig. 22, but is not shown in the figure.

[0213] Prior to a mixed injection process, a user loads syringes 501 into the syringe shelf 10. The syringes 501 are loaded into the syringe shelf 10 with needle caps 5016 attached to the needles 5014.

[0214] In this embodiment, a plurality of holes 172 are formed in the plate-like member 171 that defines each syringe shelf 10. This allows, for example, air purified by the air purifying unit 130 (see FIG. 2) to flow efficiently from the top to the bottom of the co-infusion device 1.

[0215] The multiple equipment holding parts 11 are members (holding parts) capable of holding syringes 501 to be loaded into the co-infusion apparatus 1. In this embodiment, one equipment holding part 11 holds one syringe 501, but one equipment holding part 11 may hold multiple syringes 501. In this embodiment, as shown in Fig. 23, the equipment holding part 11 comprises free rollers 1111 and an equipment clamping part 1112.

[0216] The instrument clamping parts 1112 clamp the syringe 501. In this embodiment, the instrument clamping parts 1112 clamp the flange 5013 of the syringe 501. The instrument clamping parts 1112 are provided at a height such that the syringe 501 does not touch the plate-shaped member 171 when the syringe 501 is held in the instrument holding part 11. The pair of instrument clamping parts 1112 are biased in directions approaching each other so as to be able to clamp the syringe 501.

[0217] A free roller 1111, which has a rotation axis extending in the vertical direction and is rotatable on the XY plane, is provided below the tip of the instrument clamping part 1112. The free roller 1111 holds the vicinity of the flange 5013 of the syringe 5011 clamped by the instrument clamping part 1112.

[0218] The instrument transporting section 12 is a member that transports at least one of the multiple instrument holding sections 11 to the working area Ar1. In this embodiment, the instrument transporting section 12 is an endless rotating member (rotating belt) to which the multiple instrument holding sections 11 are connected. Therefore, in this embodiment, the instrument transporting section 12 transports the instrument holding sections 11 one by one to the working area Ar1. However, the instrument transporting section 12 may be a transporting section that transports multiple instrument holding sections 11 to the working area Ar1 at one time.

[0219] The working area Ar1 is an area where the user causes at least one of the multiple instrument holding parts 11 to hold the syringe 501. The working area Ar1 is also an area where the user removes the syringe 501 held in at least one of the multiple instrument holding parts 11. In this embodiment, the working area Ar1 is an area where the user causes one instrument holding part 11 to hold the syringe 501, and where the user removes the syringe 501 held in one instrument holding part 11.

[0220] The working area Ar1 may function only as an area where the user causes at least one of the plurality of instrument holding parts 11 to hold the syringe 501. In this case, the area where the user removes the syringe 501 held in the instrument holding part 11 may be provided at a position separate from the working area Ar1. The working area Ar1 may function only as an area where the user removes the syringe 501 held in the instrument holding part 11. In this case, the area where the user causes the syringe 501 to be held in the instrument holding part 11 may be provided at a position separate from the working area Ar1.

[0221] In this embodiment, the instrument transporting unit 12 transports another instrument holding unit 11 in place of the instrument holding unit 11 located in the working area Ar1 when the object detection unit 13 detects an object (e.g., the user's hand) and then stops detecting the object as a trigger. In this case, the instrument transporting unit 12 transports another instrument holding unit 11 to the working area Ar1 when the user inserts his / her hand into the working area Ar1, the user causes the instrument holding unit 11 to hold the syringe 501, and then the user's hand leaves the working area Ar1. The instrument transporting unit 12 may transport another instrument holding unit 11 to the working area Ar1 when the syringe detection unit 14 detects the syringe 501 held by the instrument holding unit 11 or when the syringe detection unit 14 can no longer detect the syringe 501 held by the instrument holding unit 11, in addition to detecting the user's action.

[0222] In response to a transport instruction from the user, the instrument transport section 12 may transport another instrument holder 11 instead of the instrument holder 11 located in the working area Ar1. In this case, the syringe transport control section 141 may receive the transport instruction from the user via the touch panel 80, for example.

[0223] The instrument transport part 12 changes the instrument holding part 11 located in the working area Ar1, for example by rotating counterclockwise. By this transport operation, in place of the instrument holding part 11 holding the syringe 501 in the working area Ar1, another instrument holding part 11 not holding the syringe 501 can be transported to the working area Ar1.

[0224] The object detection unit 13 is a member that detects an object inserted into the working area Ar1. In this embodiment, the object detection unit 13 detects the user's hand or arm inserted into the working area Ar1.

[0225] The syringe detection unit 14 is a member that detects the syringe 501 held by the instrument holding unit 11 located in the working area Ar1. In this embodiment, when the syringe 501 is held by the instrument holding unit 11, the syringe detection unit 14 detects the syringe 5011.

[0226] The needle detection unit 15 is a detection unit that detects the needle 5014 of the syringe 501 held by the instrument holding unit 11 located in the working area Ar1. In this embodiment, the needle detection unit 15 detects the needle cap 5016 attached to the needle 5014. The needle detection unit 15 may function as the syringe detection unit. In this case, the syringe detection unit 14 does not need to be provided.

[0227] The syringe detection section 17 is a member capable of detecting the thickness of the syringe 5011. The syringe detection section 17 is provided at a position capable of detecting the syringe 5011 being transported by the instrument transport section 12. The syringe detection section 17 continues to detect, for example, the syringe 5011 being transported.

[0228] 4, the syringe shelf 10 may be provided with a nozzle detection unit 18 that detects the nozzle of a syringe 5011 held in the instrument holding unit 11 located in the working area Ar1. The nozzle detection unit 18 may be provided, for example, below the syringe detection unit 14 so as to be able to detect the nozzle 5017 of the syringe 501 held in the instrument holding unit 11.

[0229] Fig. 24 is a schematic diagram showing an example of the positional relationship between the nozzle 5017 of a syringe 501 held by the instrument holding part 11 and the nozzle detection part 18. Fig. 24 is a schematic diagram of the syringe 501 held by the instrument holding part 11 in the working area Ar1 as viewed from below.

[0230] 24, the cylinder tip detection unit 18 may include a first cylinder tip detection unit 181, a second cylinder tip detection unit 182, and a third cylinder tip detection unit 183. In FIG. 24, the first cylinder tip detection unit 181 side is in the depth direction (+Y axis direction), and the syringe side door 16 is provided on the third cylinder tip detection unit 183 side.

[0231] As shown by reference numeral 2041 in Fig. 24, the second barrel tip detection unit 182 detects light L11 reflected by the barrel tip 5017 of the middle-mouth syringe 501A when the middle-mouth syringe 501A is held in the instrument holding unit 11. As shown by reference numerals 2042 and 2043 in Fig. 24, the first barrel tip detection unit 181 and the third barrel tip detection unit 183 detect light L11 reflected by the barrel tip 5017 of the side-mouth syringe 501B when the side-mouth syringe 501B is held in the instrument holding unit 11. The second barrel tip detection unit 182 detects light L11 reflected by the barrel tip 5017 of the side-mouth syringe 501B when the side-mouth syringe 501B is held in the instrument holding unit 11 in a state rotated 90 degrees around the axis from the state shown by reference numerals 2042 and 2043 in Fig. 24.

[0232] Reference numeral 2044 in Fig. 24 indicates an example of the above-mentioned positional relationship when the side-port syringe 501B is held by the instrument holding part 11 in a state rotated 90 degrees around the axis from the state indicated by reference numerals 2042 and 2043 in Fig. 24. Reference numeral 2044 in Fig. 24 indicates a case in which, when the side-port syringe 501B is viewed from below, the nozzle 5017 is located closer to the second nozzle detection part 182 than the center of the bottom part 5018 of the syringe 5011. When the side-port syringe 501B is viewed from below in a state rotated 90 degrees around the axis from the state indicated by reference numerals 2042 and 2043 in Fig. 24, the nozzle 5017 may be located at a position farther from the second nozzle detection part 182 than the center of the bottom part 5018.

[0233] <Identifying the type of syringe> As shown in FIG. 4, the control unit 140 may include a first determination unit 151 that determines whether the syringe 501 used for mixed injection is a center-mouth syringe 501A or a side-mouth syringe 501B.

[0234] Based on the determination by the first determination unit 151, the control unit 140 can adjust the positional relationship between the syringe 501 and the vial 502 or the infusion container 503 in the mixed injection operation, for example, depending on the type of the syringe 501 (type of the nozzle 5017).

[0235] In the case of a configuration in which rotation about an axis is permitted for the syringe 501 in the held state, such as the instrument holding part 11, the position of the nozzle 5017 is not determined for the side-port syringe 501B. Therefore, for example, when it is determined that the syringe 501 to be used for mixed injection is the side-port syringe 501B, the control part 140 may adjust the above-mentioned positional relationship based on the detected position of the nozzle 5017 or the needle 5014.

[0236] In this case, the co-infusion device 1 may include an adjustment mechanism for adjusting the position of the nozzle 5017. The positional relationship may be determined in advance, and information indicating the positional relationship may be stored in the storage unit 200. Therefore, the control unit 140 may control the adjustment mechanism to adjust the position of the nozzle 5017 or the needle 5014 based on the detected position of the nozzle 5017 or the needle 5014 and the information indicating the positional relationship.

[0237] The adjustment mechanism may be provided in the base 44, or in the instrument holding part 11. When the adjustment mechanism is provided in the instrument holding part 11, the adjustment mechanism may adjust the position of the nozzle 5017 or the needle 5014 by rotating the syringe 501 held in the instrument holding part 11 around an axis.

[0238] Furthermore, the control unit 140 can determine, for example, whether the syringe 501 used when mixing and injecting a certain drug into an infusion is an appropriate syringe 501 for that use, based on the determination by the first determination unit 151. Then, the syringe transport control unit 141 can transport an appropriate syringe 501 to be used for mixing and injecting, to a removal position from which the first transport unit 110 removes the syringe 501. The control unit 140 can realize the transportation of the appropriate syringe 501 by storing, in the memory unit 200, information (e.g., a number) for identifying each instrument holding unit 11 and information indicating the type of the syringe 501 held in the instrument holding unit 11 in association with each other.

[0239] Also, consider a case where the control unit 140 determines that the syringe 501 used for mixed injection is not an appropriate syringe 501, and determines that an appropriate syringe 501 to be used for mixed injection is not held in the instrument holding unit 11. In this case, the touch panel control unit 150 can notify via the touch panel 80 that an appropriate syringe 501 to be used for mixed injection is not held in the instrument holding unit 11.

[0240] The first determination section 151 may determine the type of the syringe 501 held in the instrument holding section 11 based on the detection results of the needle detection section 15, the nozzle detection section 18, or the syringe detection section 17. This makes it possible to identify the type of the syringe 501 held in the instrument holding section 11.

[0241] For example, the first judgment unit 151 may determine whether the syringe 501 held in the instrument holding unit 11 is a center-mouth syringe 501A or a side-mouth syringe 501B based on the detection results of the first barrel tip detection unit 181, the second barrel tip detection unit 182, and the third barrel tip detection unit 183.

[0242] As described above, when the side-ported syringe 501B is held in the instrument holding part 11 in the state shown by reference numeral 2042 in Fig. 24, the first barrel tip detection part 181 detects light L11. When the side-ported syringe 501B is held in the instrument holding part 11 in the state shown by reference numeral 2043 in Fig. 24, the third barrel tip detection part 183 detects light L11. Therefore, when the first barrel tip detection part 181 or the third barrel tip detection part 183 detects light L11, the first judgment part 151 judges that the syringe 501 held in the instrument holding part 11 is the side-ported syringe 501B.

[0243] On the other hand, as described above, when a center-mouth syringe 501A is held in the instrument holding part 11 in the state shown by reference numeral 2041 in Fig. 24, the second barrel tip detection part 182 detects light L11. Also, when a side-mouth syringe 501B is held in the instrument holding part 11 in the state shown by reference numeral 2044 in Fig. 24, the second barrel tip detection part 182 detects light L11. Therefore, when the second barrel tip detection part 182 detects light L11, the syringe 501 held in the instrument holding part 11 may be either the center-mouth syringe 501A or the side-mouth syringe 501B.

[0244] However, a first time taken for the light emitted by second barrel tip detection unit 182 to be reflected by middle-mouth syringe 501A and return to second barrel tip detection unit 182, and a second time taken for the light to be reflected by side-mouth syringe 501B and return to second barrel tip detection unit 182 are different from each other.

[0245] When the side-port syringe 501B is held in the instrument holding part 11 in the state shown by reference numeral 2044 in Fig. 24, the distance between the barrel tip 5017 of the side-port syringe 501B and the second barrel tip detection part 182 is shorter than the distance between the barrel tip 5017 and the second barrel tip detection part 182 of the middle-port syringe 501A when held in the instrument holding part 11. Therefore, when the side-port syringe 501B is held in the instrument holding part 11 in the state shown by reference numeral 2044 in Fig. 24, the second time is shorter than the first time.

[0246] On the other hand, consider a case where the side-port syringe 501B is held in the instrument holding part 11 with the tip 5017 located at a position farther from the second tip detection part 182 than the center of the bottom part 5018 when viewed from below. In this case, the distance between the tip 5017 of the side-port syringe 501B and the second tip detection part 182 is longer than the distance between the tip 5017 of the middle-port syringe 501A and the second tip detection part 182 when held in the instrument holding part 11. Therefore, when the side-port syringe 501B is held in the instrument holding part 11 with the tip 5017 located at a position farther from the second tip detection part 182 than the center of the bottom part 5018, the second time is longer than the first time.

[0247] Therefore, when the second barrel tip detection unit 182 detects light L11, the first judgment unit 151 can determine whether the syringe 501 held in the instrument holding unit 11 is a center-mouth syringe 501A or a side-mouth syringe 501B based on the time it takes for the emitted light to be reflected by the syringe 501 and return to the second barrel tip detection unit 182.

[0248] Specifically, the control unit 140 measures the time it takes for the light emitted by the second barrel tip detection unit 182 to be reflected by the syringe 501 and return to the second barrel tip detection unit 182. When the second barrel tip detection unit 182 detects the light L11, the first determination unit 151 determines whether the syringe 501 held in the instrument holding unit 11 is a center-mouth syringe 501A or a side-mouth syringe 501B by determining whether the measured time is between a first threshold value T11 and a second threshold value T12.

[0249] Specifically, when the first determination unit 151 determines that the measured time is between the first threshold value T11 and the second threshold value T12 (when T11 ≤ measured time ≤ T12), it determines that the syringe 501 held by the instrument holding unit 11 is the middle-port syringe 501A. On the other hand, when the first determination unit 151 determines that the measured time is less than the first threshold value T11 or greater than the second threshold value T12 (when the measured time < T11 or T12 < measured time), it determines that the syringe 501 held by the instrument holding unit 11 is the side-port syringe 501B.

[0250] The information indicating the first threshold value T11 and the second threshold value T12 is stored in the storage unit 200. The first threshold value T11 and the second threshold value T12 may be determined, for example, through experiments or the like, as long as it is possible to determine whether the syringe 501 held by the instrument holding unit 11 is the middle-port syringe 501A or the side-port syringe 501B when the second barrel tip detection unit 182 detects the light L11.

[0251] Also, three needle detection units 15 may be provided, such as the barrel tip detection unit 18. In this case, the first determination unit 151 may determine whether the syringe 501 held by the instrument holding unit 11 is the middle-port syringe 501A or the side-port syringe 501B based on the detection results of the three needle detection units 15.

[0252] Also, for example, the storage unit 200 stores information indicating the speed of the instrument transport unit 12 in front of the syringe detection unit 17 and information indicating the thickness of various syringes 5011 that can be used in admixture injection. The control unit 140 calculates the thickness of the syringe 5011 that has passed in front of the syringe detection unit 17 based on the detection time of the syringe 5011 by the syringe detection unit 17 and the speed of the instrument transport unit 12. Thereby, the control unit 140 can specify the thickness of the syringe 5011 that has passed in front of the syringe detection unit 17 (the type of the syringe 501 held by the instrument holding unit 11).

[0253] As described above, the thicknesses of the center-mouth syringe 501A and the side-mouth syringe 501B used in the co-infusion apparatus 1 may be different from each other. In this case, the first determination unit 151 can determine whether the syringe 501 held in the equipment holding unit 11 is the center-mouth syringe 501A or the side-mouth syringe 501B, depending on the thickness of the syringe 5011 that has passed in front of the syringe detection unit 17.

[0254] Furthermore, for example, the co-infusion device 1 may be provided with a camera that captures an image of the syringe 501 held in the equipment holding section 11. In this case, for example, an image of a middle-mouth syringe 501A and an image of a side-mouth syringe 501B are stored in the memory section 200. The first determination section 151 may determine whether the syringe 501 held in the equipment holding section 11 is the middle-mouth syringe 501A or the side-mouth syringe 501B based on the image captured by the camera and the image stored in the memory section 200.

[0255] In this embodiment, the first determination section 151 determines whether the syringe 501 held by the equipment holding section 11 is a center-mouth syringe 501A or a side-mouth syringe 501B. This makes it possible to determine the type of the syringe 501 before the start of the mixed injection operation by the mixed injection unit 40 (during standby for the mixed injection operation). Therefore, the time required for mixed injection can be shortened, compared to, for example, determining the type of the syringe 501 during the mixed injection operation and adjusting its position.

[0256] However, the present invention is not limited thereto, and the first determination unit 151 may determine, for example, whether the syringe 501 held in the syringe holding unit 41 (holding unit) is a middle-mouth syringe 501A or a side-mouth syringe 501B. In this case, for the determination by the first determination unit 151, a detection unit for detecting the syringe 5011, the needle 5014, or the nozzle 5017 of the syringe 501 held in the mixed injection unit 40 is provided at a position where the syringe 5011, the needle 5014, or the nozzle 5017 can be detected.

[0257] <Judgment of syringe fitting suitability> 4, the control section 140 may include a second determination section 152 that determines whether the side-port syringe 501B is properly attached to the instrument holding section 11. This allows the touch panel control section 150 to notify the user that the side-port syringe 501B is not properly attached via the touch panel 80 when the side-port syringe 501B is not properly attached. This allows the user to properly reattach the side-port syringe 501B.

[0258] Figure 25 is a diagram showing an instrument holding part 11A which is a modified example of the instrument holding part 11. Reference numeral 2051 in Figure 25 is a perspective view of the instrument holding part 11A, and reference numeral 2052 in Figure 25 is a bottom view of the instrument holding part 11A. Figure 25 shows an example in which a side-mouth syringe 501B is attached to the instrument holding part 11A. Reference numeral 2053 in Figure 25 is a diagram for explaining the rotation of the side-mouth syringe 501B.

[0259] 25, the instrument holding part 11A is provided with a fixing member 19 that fixes the position of the syringe 501 held in the instrument holding part 11A. The fixing member 19 fixes the side-ported syringe 501B held in the instrument holding part 11A so that the side-ported syringe 501B does not rotate around the axis of the side-ported syringe 501B.

[0260] In this embodiment, the fixing member 19 includes a first insertion portion 191 into which the syringe 5011 is inserted, and a second insertion portion 192 into which the cylindrical tip 5017 is inserted.

[0261] The first insertion portion 191 has a shape and size that allows the insertion of the center-mouth syringe 501A and the side-mouth syringe 501B. Specifically, the shape and size of the first insertion portion 191 are specified so that the nozzle 5017 (needle cap 5016) is inserted into the second insertion portion 192 whether the center-mouth syringe 501A or the side-mouth syringe 501B is inserted.

[0262] The second insertion part 192 has a shape and size into which the nozzles 5017 of the center-port syringe 501A and the side-port syringe 501B inserted into the first insertion part 191 can be inserted, and which can restrict rotation around the axis of the side-port syringe 501B inserted into the first insertion part 191. As indicated by reference numeral 2052 in Fig. 25, the second insertion part 192 may be in the shape of a groove extending in the insertion direction of the syringe 501 into the instrument holding part 11A.

[0263] When the side-port syringe 501B is held in the instrument holding section 11A in an appropriate orientation, the nozzle 5017 of the side-port syringe 501B is inserted into the second insertion section 192, as shown by reference numeral 2052 in FIG. 25. The side-port syringe 501B being held in an appropriate orientation in the instrument holding section 11A means that the side-port syringe 501B can be used in a mixed injection operation without rotating the side-port syringe 501B around its axis. However, even when the side-port syringe 501B is held in the instrument holding section 11A in an orientation 180 degrees opposite to the appropriate orientation, the nozzle 5017 of the side-port syringe 501B is inserted into the second insertion section 192, as shown by reference numeral 2052 in FIG.

[0264] Therefore, by using the fixing member 19 having the second insertion portion 192, the nozzle 5017 of the side-port syringe 501B is located at the position shown by either of the reference symbols 2042 and 2043 in Fig. 24. This means that when the side-port syringe 501B is inserted into the fixing member 19, the nozzle 5017 is not located at a position rotated 90 degrees from the state shown by the reference symbols 2042 and 2043 in Fig. 24, for example.

[0265] Consider a case where, when the side-mouth syringe 501B is held in an appropriate orientation in the instrument holding section 11A, the position of the nozzle 5017 of the side-mouth syringe 501B is substantially the same as the position of the nozzle 5017 of the middle-mouth syringe 501A in a direction perpendicular to the insertion direction of the nozzle 5017 and the axial direction. In this case, for example, the needle detection section 15 can detect the needle cap 5016 of the middle-mouth syringe 501A inserted into the second insertion section 192 and the needle cap 5016 of the side-mouth syringe 501B inserted into the second insertion section 192 in an appropriate orientation. The needle detection section 15 is disposed at a position where it can detect the needle caps 5016 of the middle-mouth syringe 501A and the side-mouth syringe 501B inserted in this manner.

[0266] When the needle detection unit 15 detects light reflected by the needle cap 5016 of the syringe 501, if the syringe 501 inserted into the fixing member 19 is a side-port syringe 501B, the second determination unit 152 determines that the side-port syringe 501B is properly held in the instrument holding unit 11A. The determination of whether the syringe 501 is a center-port syringe 501A or a side-port syringe 501B may be made using, for example, the syringe detection unit 17, as described above.

[0267] Furthermore, the second determination unit 152 does not have to determine whether the side-port syringe 501B is properly attached to the instrument holding part 11 based on the detection result of the needle detection part 15. For example, the second determination unit 152 may perform the above determination based on the detection result of the nozzle detection part 18, or the imaging result of a camera that images the nozzle 5017 or the needle cap 5016. In this case, when the side-port syringe 501B is held in the instrument holding part 11A in an appropriate orientation, the position of the nozzle 5017 of the side-port syringe 501B does not have to be approximately the same as the position of the nozzle 5017 of the middle-port syringe 501A in the direction perpendicular to the insertion direction of the nozzle 5017 and the axial direction.

[0268] When using the cylinder tip detection unit 18, the co-infusion device 1 does not need to include either the first cylinder tip detection unit 181 or the third cylinder tip detection unit 183. For example, when the first cylinder tip detection unit 181 is arranged so that the first cylinder tip detection unit 181 can detect the light L11 when the side-mouth syringe 501B is properly attached to the instrument holding unit 11A, the co-infusion device 1 does not need to include the third cylinder tip detection unit 183.

[0269] When the side-port syringe 501B is held in the instrument holding part 11A in the appropriate orientation, the first barrel tip detection part 181 detects the light L11. Therefore, when the first barrel tip detection part 181 detects the light L11, the second judgment part 152 judges that the side-port syringe 501B is appropriately attached to the instrument holding part 11. On the other hand, when neither the first barrel tip detection part 181 nor the second barrel tip detection part 182 detects the light L11 even though the instrument holding part 11A holds the syringe 501, the second judgment part 152 judges that the side-port syringe 501B is not appropriately attached to the instrument holding part 11.

[0270] As shown by the reference numeral 2053 in FIG. 25, when the side-mouth syringe 501B rotates in the axial direction, the position of the needle cap 5016 (the tip of the side-mouth syringe 501B) differs depending on the orientation in which the side-mouth syringe 501B is attached. Therefore, if the orientation in which the side-mouth syringe 501B is attached is not appropriate, the puncture position of the needle 5014 into the vial 502 or the infusion container 503 may be shifted during the mixed injection operation, and the liquid medicine or the infusion may not be able to be extracted. By the determination by the second determination unit 152, the side-mouth syringe 501B can be held in the equipment holding unit 11A so that the orientation of the side-mouth syringe 501B is appropriate. Therefore, the possibility of the puncture position being shifted can be reduced. In other words, the possibility of the mixed injection operation being performed in a state in which the orientation of the side-mouth syringe 501B is not appropriate can be reduced.

[0271] In addition, the fixing member 19 regulates the position of the tip of the side-port syringe 501B held by the instrument holding part 11A. This allows the instrument holding part 11A to hold the filled side-port syringe 501B in a position in which the position of the tip of the side-port syringe 501B is within a certain range. In addition, by using the instrument holding part 11A, the second judgment part 152 can judge whether the side-port syringe 501B is properly attached to the instrument holding part 11A based on the detection result of the tip of the side-port syringe 501B. Therefore, the co-infusion device 1 does not need to be provided with a detection part that detects the positional deviation of the side-port syringe 501B due to the rotation of the side-port syringe 501B in the axial direction, and the processing time can be shortened by the operation time of the detection part.

[0272] Since the instrument holding part 11A is provided with the fixing member 19 and the needle detection part 15 or the cylinder tip detection part 18, the processing of the second judgment part 152 is performed while the instrument holding part 11A is holding the side-mouth syringe 501B. This is not limiting, and the processing of the second judgment part 152 may be performed before the mixed injection operation. Therefore, the detection part that detects the fixing member 19 and the tip of the side-mouth syringe 501B may be provided in the mixed injection unit 40, for example.

[0273] <Assistance with filling or retrieving syringes> As described above, a light emitting member may be provided corresponding to each syringe shelf 10. In this case, the control unit 140 may light up the light emitting member corresponding to one syringe shelf 10 when syringes 501 are held in all the instrument holding parts 11 provided in one syringe shelf 10. Furthermore, the control unit 140 may light up the light emitting member corresponding to one syringe shelf 10 when syringes 501 are not held in all the instrument holding parts 11 provided in one syringe shelf 10 (for example, when all the syringes 501 held in the instrument holding parts 11 have been removed).

[0274] This allows the user to recognize the timing of completion of filling or withdrawal of the syringe 501 without visually checking the holding state of the syringe 501 in all of the instrument holding parts 11. Therefore, the user can close the syringe-side door 16 at the timing of completion of filling or withdrawal of the syringe 501.

[0275] The first transport unit 110 can only remove the syringe 501 from the syringe shelf 10 in which the syringe side door 16 is in the locked state. Therefore, the first transport unit 110 cannot remove the syringe 501 from the syringe shelf 10 in which the syringe side door 16 is provided unless the syringe side door 16 is closed and locked. As described above, by issuing a notification to close the syringe side door 16 at the above-mentioned timing via the light-emitting member, it is possible to reduce the standby time of the first transport unit 110.

[0276] The control unit 140 manages the positions of the instrument holding units 11. For example, the control unit 140 manages the instrument holding units 11 located in the working area Ar1. The control unit 140 can determine whether the instrument holding units 11 located in the working area Ar1 are holding a syringe 501 based on the detection result of the syringe detection unit 14. The control unit 140 can determine whether the syringe 501 is being held in all of the instrument holding units 11 by correlating information identifying each instrument holding unit 11 with information indicating whether or not the syringe 501 is being held in the memory unit 200.

[0277] Furthermore, when the control unit 140 causes the first transport unit 110 to take out the syringe 501 to be removed, if the syringe side door 16 of the syringe shelf 10 holding the syringe 501 is in an open state, the control unit 140 may turn on the light emitting member corresponding to the syringe shelf 10. This makes it possible to reduce the standby time of the first transport unit 110.

[0278] <Transport control of equipment holder> The control section 140 may manage the instrument holding section 11 that last held the syringe 501 (information identifying the instrument holding section 11). The syringe transport control section 141 transports to the working area Ar1 the instrument holding section 11 that is closest to the instrument holding section 11 that last held the syringe 501 and that does not hold the syringe 501 (empty instrument holding section 11) on the rear side in the transport direction of the instrument holding section 11. When the user closes the syringe side door 16 after completing filling of the syringe 501 and then opens the syringe side door 16 to fill the syringe 501 again, the empty instrument holding section 11 may be transported to the working area Ar1.

[0279] This reduces the possibility of uneven frequency of use of the instrument holding parts 11. Also, syringes 501 filled at the same time can be managed together on the syringe shelf 10. Furthermore, since the empty instrument holding part 11 closest to the instrument holding part 11 that last held the syringe 501 in the transport direction is transported to the working area Ar1, the waiting time for the filling operation of the syringe 501 can be reduced.

[0280] [Specific configuration of vial shelf] As indicated by reference numeral 2031 in Figures 22 and 23, the vial shelf 20 comprises a plurality of instrument holding parts 21, an instrument transport part 22, an object detection part 23, and a vial detection part 24. Also, as indicated by reference numeral 2031 in Figure 23, the vial shelf 20 comprises a first reading part 25, and a roller driving part 26. Note that an instrument holding part 21 is also attached to the attachment part 221 of the instrument transport part 22 shown in Figure 22, but this is not shown in the figure.

[0281] Prior to the mixed injection process, the vial shelf 20 is filled with vials 502 by a user. The vials 502 are provided with stoppers (rubber stoppers) 5021 (see FIG. 5) that close the openings and lids that cover the stoppers 5021. The vials 502 are filled in the vial shelf 20 with the lids removed. Similarly to the syringe shelf 10, a plurality of holes 172 are formed in the plate-like member 171 that defines each vial shelf 20.

[0282] The instrument holding part 21 is a member capable of holding a vial 502. In this embodiment, one instrument holding part 21 holds one vial 502, but one instrument holding part 21 may hold a plurality of vials 502.

[0283] In this embodiment, as shown in FIG. 23, the object holding part 21 includes free rollers 211, an object clamping part 212, a driving roller 213, and a first magnet gear 214.

[0284] The instrument clamping part 212 clamps the vial 502. In this embodiment, the instrument clamping part 212 clamps the neck part of the vial 502. The instrument clamping part 212 is provided at a height such that the vial 502 does not touch the plate-like member 171 when the vial 502 is held by the instrument holding part 21.

[0285] The pair of instrument clamping parts 212 are biased in a direction approaching each other so as to be able to clamp the vial 502. A free roller 211 is provided at the tip of the instrument clamping part 212, which has a rotation axis extending in the vertical direction and is rotatable on the XY plane. As indicated by reference numeral 2032 in FIG. 23, the free roller 211 supports the neck of the vial 502 at three points together with a drive roller 213 provided at a position opposite the center of the free roller 211 on the side on which the instrument clamping part 212 is axially supported. In this way, the instrument clamping part 212 holds the vial 502. When the drive roller 213 rotates while holding the vial 502, the vial 502 also rotates. In conjunction with this rotation, the free roller 211 also rotates.

[0286] A first magnet gear 214 is provided on the upper part of the driving roller 213. The driving roller 213 and the first magnet gear 214 are connected to a common rotation shaft extending in the vertical direction and are rotatable on the XY plane. When the first magnet gear 214 rotates in accordance with the rotation of the second magnet gear 261 provided in the roller driving unit 26, the driving roller 213 also rotates.

[0287] The instrument transporting section 22 is a member that transports at least one of the multiple instrument holding sections 21 to the working area Ar2. In this embodiment, the instrument transporting section 22 is an endless rotating member to which the multiple instrument holding sections 21 are connected. Therefore, in this embodiment, the instrument transporting section 22 transports the instrument holding sections 21 one by one to the working area Ar2. However, the instrument transporting section 22 may be a transporting section that transports multiple instrument holding sections 21 to the working area Ar2 at one time.

[0288] Like the working area Ar1, the working area Ar2 is an area where the user causes at least one of the multiple equipment holders 21 to hold the vial 502. Also, the working area Ar2 is an area where the user removes the vial 502 held in at least one of the multiple equipment holders 21. Also, like the working area Ar1, the working area Ar2 may be an area that functions only as an area for holding the vial 502, or an area that functions only as an area for removing the vial 502.

[0289] In this embodiment, the instrument transporting section 22 has the same function as the instrument transporting section 12. Specifically, the instrument transporting section 22 transports another instrument holding section 21 in place of the instrument holding section 21 located in the working area Ar2 when the object detection section 23 detects an object (e.g., the user's hand) and then stops detecting the object, which is a trigger. The instrument transporting section 12 may transport another instrument holding section 11 to the working area Ar2 when the vial detection section 24 detects the vial 502 held in the instrument holding section 21 or when the vial detection section 24 can no longer detect the vial 502 held in the instrument holding section 21, in addition to detecting the user's movement. The instrument transporting section 12 changes the instrument holding section 21 located in the working area Ar2 by, for example, rotating counterclockwise.

[0290] Furthermore, like the syringe transport control unit 141, the vial transport control unit 142 may transport another instrument holding unit 21 in place of the instrument holding unit 21 located in the working area Ar2, for example, in response to a transport instruction from the user.

[0291] The object detection unit 23 is a member that detects an object inserted into the working area Ar2. In this embodiment, the object detection unit 23 detects the user's hand or arm inserted into the working area Ar2. The vial detection unit 24 detects the vial 502 held in the instrument holder 21 located in the working area Ar2.

[0292] The first reading unit 25 is a member that reads type information indicating the type of drug contained in the vial 502, which is indicated on the surface of the vial 502, in a part of the transport path along which the instrument transporting unit 22 transports the multiple instrument holding units 21. The vial 502 may be provided with a barcode on which the type information is recorded. In this case, the first reading unit 25 may be a barcode reader. As indicated by reference numeral 2031 in FIG. 23, the first reading unit 25 is disposed at a position where it can read the barcode of the vial 502 transported to the removal position PO11. The removal position PO11 is a position where the first transporting unit 110 removes the vial 502.

[0293] The roller driving unit 26 is a motor that rotates the second magnet gear 261 attached to the roller driving unit 26 in order to rotate the driving roller 213 of the instrument holding unit 21. When the vial transport control unit 142 drives the roller driving unit 26, the second magnet gear 261 also rotates. The first magnet gear 214 rotates in conjunction with the rotation of the second magnet gear 261. The driving roller 213 connected to a common rotation shaft with the first magnet gear 214 rotates in conjunction with the rotation of the first magnet gear 214, thereby rotating the vial 502 that is in contact with the driving roller 213. By rotating the vial 502 in this manner, the first reading unit 25 can read the barcode no matter where the barcode is attached on the surface of the vial 502.

[0294] <Example 1 of vial recovery> The control unit 140 may receive an instruction to collect the vial 502, for example, via the touch panel 80. When the vial transport control unit 142 receives the instruction to collect the vial 502, it controls the instrument transport unit 22 to transport the vial 502 to the work area Ar2 in the vial shelf 20 storing the vial 502 to be collected. When a plurality of vials 502 to be collected are stored, the vial transport control unit 142 may control the instrument transport unit 22 to preferentially transport the instrument holding unit 21 that holds the vial 502 that is held last in the instrument holding unit 21 to the work area Ar2. In this case, the memory unit 200 stores information indicating the holding order of the vials 502 in association with the position of the instrument holding unit 21 (information identifying the instrument holding unit 21).

[0295] <Example 2 of vial recovery> Depending on the type of the vial 502, there may be a vial 502 (hereinafter referred to as a separation vial) that needs to be discarded separately from other vials 502. The first transport unit 110 may not transport the separation vial to the trash box unit 70 after the co-infusion operation is completed. In this case, the touch panel control unit 150 may notify the user via the touch panel 80 that the vial 502 used for the co-infusion is a separation vial, or that the vial 502 should be removed from the co-infusion device 1. This allows the user to remove the separation vial from the co-infusion device 1 without discarding it in the trash box unit 70.

[0296] The trash can section 70 may have a trash can section for separation only for separation vials and a trash can section for normal use only for vials 502 other than separation vials (hereinafter referred to as normal vials). The first transport control section 143 may control the first transport section 110 to transport the vial 502 to the trash can section for separation when the vial 502 used for mixed injection is a separation vial. The first transport control section 143 may transport the vial 502 to the normal trash can section when the vial 502 used for mixed injection is a normal vial. In this operation, the information indicating the type of the vial 502 may include information indicating a normal vial or a separation vial.

[0297] <Vial filling or recovery support / instrument holding section transport control> As described above, a light emitting member may be provided corresponding to each of the vial shelves 20. In this case, the control unit 140 may light up the light emitting member corresponding to one vial shelf 20 when vials 502 are held in all the equipment holding units 21 provided in one vial shelf 20. Furthermore, the control unit 140 may light up the light emitting member corresponding to the vial shelf 20 when vials 502 are not held in all the equipment holding units 21 provided in one vial shelf 20 (for example, when all the vials 502 held in the equipment holding units 21 have been removed). A specific description will be omitted because it is sufficient to replace the terms related to the syringe shelf 10 in the above description of "Support for filling or collecting syringes" with the terms related to the vial shelf 20.

[0298] Furthermore, the vial transport control section 142 may transport to the working area Ar2 the equipment holding section 21 that is closest to the equipment holding section 21 that last held the vial 502 in the transport direction of the equipment holding sections 21 and that is not holding a vial 502 (an empty equipment holding section 21). A specific explanation is omitted here because it is sufficient to replace the terms related to the syringe shelf 10 in the above explanation of "Transport control of equipment holding sections" with terms related to the vial shelf 20.

[0299] [Specific configuration of the second conveying section] Fig. 26 is a diagram showing an example of the configuration of the second transport section 120. As indicated by reference numeral 2061 in Fig. 26, the second transport section 120 includes an adsorption section 121 and a third reading section 122.

[0300] The suction part 121 is a member that suctions the body part 5031 of the infusion container 503. The suction part 121 is an example of a holding member that holds the infusion container 503, and as long as the second transport unit 120 can hold the infusion container 503, the holding member does not have to be the suction part 121. The second transport control unit 145 detaches the infusion container 503 by controlling the air pressure in the suction part 121.

[0301] In this embodiment, three suction parts 121 are provided along the up-down direction at positions facing the infusion container 503 in the second transporting part 120. The three suction parts 121 include a main suction part 121A and two sub suction parts 121B. The suction part 121 may include a plurality of main suction parts 121A, and may include only one or three or more sub suction parts 121B.

[0302] The main suction part 121A is always used to adsorb the infusion container 503 when the second transport part 120 holds the infusion container 503. The main suction part 121A is provided at a position capable of facing all of the infusion containers 503 of different sizes that can be stored in the co-infusion device 1. The two sub-suction parts 121B adsorb the infusion container 503 together with the main suction part 121A depending on the vertical size of the infusion container 503. Therefore, at least one of the two sub-suction parts 121B may not adsorb the infusion container 503 depending on the size of the infusion container 503.

[0303] The type (size) of the infusion container 503 and the suction part 121 used to suction the infusion container 503 are determined in advance, and information associating them is stored in the storage unit 200. Therefore, the second transport control unit 145 can specify the type of the infusion container 503 used for mixed injection based on the preparation / administration data, thereby specifying the suction part 121 used to suction the infusion container 503. In addition, the positional relationship between the suction location of the infusion container 503 (e.g., the infusion shelf 30 and the mixed injection unit 40) and the second transport unit 120 is determined in advance so that the main suction part 121A is always used when the second transport unit 120 holds the infusion container 503.

[0304] As indicated by reference numeral 2062 in Fig. 26, the main suction part 121A is a member that expands and contracts in the direction in which it adheres to the infusion container 503, and is flexible. In this embodiment, the main suction part 121A has a bellows structure. The auxiliary suction part 121B does not have to be a member that expands and contracts in the direction in which it adheres to the infusion container 503, and is flexible. In addition, the length of the main suction part 121A in the adsorption direction is greater than the length of the auxiliary suction part 121B.

[0305] When the second conveying section 120 adsorbs the infusion container 503, it approaches the storage location of the infusion container 503. At this time, the main adsorption section 121A comes into contact with the infusion container 503 before the sub-adsorption section 121B. Since the main adsorption section 121A is a member that expands and contracts and bends, the main adsorption section 121A can make the adsorption port (suction port) follow the direction of the surface of the infusion container 503 regardless of the direction of the surface. Therefore, the surface of the infusion container 503 can be adsorbed regardless of the direction of the infusion container 503. When the surface of the infusion container 503 is obliquely oriented with respect to the second conveying section 120, the main adsorption section 121A tries to return to a state where it is no longer bent, so that the surface (largest surface) of the infusion container 503 can be oriented toward the second conveying section 120.

[0306] On the other hand, since the main suction part 121A is made of the above-mentioned material, the main suction part 121A is more flexible than the sub suction part 121B. Or, the suction force of the main suction part 121A is weaker than that of the sub suction part 121B. Therefore, when only the main suction part 121A is used for suction, the infusion container 503 may fall during transportation. In addition, since the infusion container 503 may wobble when the second transport part 120 accelerates or decelerates, there is a risk that the infusion container 503 cannot be delivered to the transport destination until the wobbling stops.

[0307] In this embodiment, even after the main suction part 121A comes into contact with the surface of the infusion container 503, the second transport part 120 moves toward the infusion container 503. At this time, the main suction part 121A contracts, and the sub suction part 121B comes into contact with the infusion container 503. Unlike the main suction part 121A, the sub suction part 121B cannot make the suction port follow the direction of the infusion container 503, but can suction the infusion container 503 because the infusion container 503 is fixed to some extent by the main suction part 121A.

[0308] The auxiliary suction part 121B is less likely to bend than the main suction part 121A. Or, the suction force of the auxiliary suction part 121B is stronger than that of the main suction part 121A. Therefore, the possibility that the infusion container 503 falls during transportation can be reduced. Also, the possibility that the infusion container 503 wobble due to acceleration or deceleration of the second transport part 120 can be reduced.

[0309] The third reading unit 122 reads information contained in a first label attached to the body 5031 of the infusion container 503. When the information contained in the first label is contained in a barcode, the third reading unit 122 may be realized by a barcode reader.

[0310] [Configuration of infusion shelf] Fig. 27 is a perspective view showing an example of the configuration of the infusion shelf 30. As shown in Fig. 27, the infusion shelf 30 includes a pusher section 31, a pusher transport section 35, and a rail section 36. In addition, as shown in Fig. 3, the infusion shelf 30 includes a shutter 37.

[0311] Prior to the mixed injection process, the infusion shelf 30 is filled with infusion containers 503 by the user. Similarly to the syringe shelf 10 and the vial shelf 20, the plate-like member 301 defining each infusion shelf 30 has a plurality of holes 302 formed therein.

[0312] The rail portion 36 is a member provided inside the infusion shelf 30 and extending from the infusion side door 34 (see FIG. 1) side toward the back of the co-infusion device 1 (i.e., in the +Y-axis direction). In the rail portion 36, the end portion located on the infusion side door 34 side can be called the door side end portion 361, and the end portion located on the back side of the co-infusion device 1 can be called the back side end portion 362. The infusion container 503 is loaded into the rail portion 36 from the door side end portion 361, and is taken out by the second conveying unit 120 from the back side end portion 362. At least one infusion container 503 can be hung on the rail portion 36. In this embodiment, the neck portion of the infusion container 503 can be hung between a pair of rail portions 36. Specifically, a flange 5034 (see FIG. 26 for the neck portion 5033 and the flange 5034) which is a part of the neck portion 5033 of the infusion container 503 can be hung between the pair of rail portions 36.

[0313] In this embodiment, each infusion shelf 30 is provided with three rail portions 36. However, the number of rail portions 36 provided on each infusion shelf 30 is not limited to three. In this embodiment, each of the rail portions 36 is filled with the same type of infusion containers 503 (infusion containers having the same type of infusion contained in the infusion container 503 and the same size of the infusion container 503). The infusion containers 503 to be filled are determined for each infusion shelf 30. However, each of the rail portions 36 may be filled with different types of infusion containers 503.

[0314] The pushing unit 31 is a member that can move along the rail portion 36 and pushes the infusion container 503 suspended from the rail portion 36 from the door side end portion 361 to the back side end portion 362. In this embodiment, the pushing unit 31 is connected to the pushing transport portion 35. The pushing transport portion 35 is provided along the rail portion 36. The pushing transport portion 35 can move the pushing unit 31 along the rail portion 36 by operating under the control of the pushing control unit 147. The pushing transport portion 35 may be, for example, an endless rotating member. The size of the pushing unit 31 and the positional relationship between the rail portion 36 and the pushing transport portion 35 are specified so that the infusion container 503 suspended from the rail portion 36 can be pushed in by the movement of the pushing unit 31.

[0315] When the infusion side door 34 is unlocked or open, the pushing unit 31 is located at a position PO31 on the door side end 361 side and does not interfere with the filling (hanging on the rail portion 36) of the infusion container 503. The pushing control unit 147 may move the pushing unit 31 to the position PO31 by controlling the pushing transport unit 35 when, for example, a button 90 (see FIG. 1) on the infusion shelf 30 is pressed (when the infusion side door 34 is unlocked).

[0316] When the infusion side door 34 is locked, the pushing unit 31 pushes the infusion container 503 suspended from the rail unit 36 ​​from the door side end 361 to the back end 362. In this embodiment, when the infusion side door 34 is locked after being closed, the pushing control unit 147 controls the pushing transport unit 35 to move the pushing unit 31 from the position PO31 to the back end 362. The back end 362 of the wall constituting the infusion shelf 30 is provided with a detection unit (not shown) for detecting the infusion container 503 present at the back end 362. The pushing control unit 147 moves the pushing unit 31 toward the back end 362 until the detection unit detects the infusion container 503.

[0317] Also, consider a case where the second transport unit 120 removes an infusion container 503 located at the rear end 362 while multiple infusion containers 503 are suspended from the rail unit 36. After the second transport unit 120 removes the infusion container 503, the pushing unit 31 pushes the remaining infusion containers 503 suspended from the rail unit 36 ​​from the door side end 361 to the rear end 362. In this embodiment, when the second transport unit 120 removes the infusion container 503 located at the rear end 362, the pushing control unit 147 controls the pushing transport unit 35 to move the pushing unit 31 further to the rear end 362.

[0318] The shutter 37 is located at the rear side of the infusion shelf 30 when the infusion side door 34 is open, and blocks the rear end 362 from the area on the rear side (+Y axis direction) so that the user cannot touch the second transport section 120 even if he or she puts his or her hand into the infusion shelf 30 from the infusion side door 34 side. The shutter 37 is controlled by the shutter control section 148 to be movable in the vertical direction.

[0319] For example, when the infusion side door 34 is opened, the shutter 37 is controlled by the shutter control unit 148 to be located at the back side of the infusion shelf 30 corresponding to the infusion side door 34. For example, when the shutter control unit 148 receives a user operation on a button 90, the shutter control unit 148 moves the shutter 37 to a position facing the back end 362 of the infusion shelf 30 corresponding to the button 90.

[0320] Furthermore, when the second transport unit 120 removes an infusion container 503, the shutter 37 moves to an infusion shelf 30 other than the infusion shelf 30 in which the infusion container 503 is stored. For example, when the shutter 37 is located at a position facing the infusion shelf 30 in which the infusion container 503 to be removed by the second transport unit 120 is held, the shutter control unit 148 moves the shutter 37 to a position facing another infusion shelf 30. The memory unit 200 stores information indicating the storage position of the infusion container 503 on the infusion shelf 30, for example, in association with infusion type information.

[0321] <Conveying method of the second conveying section> 28 is a diagram for explaining an example of a transport method of the second transport unit 120. In this embodiment, two infusion shelves 30 are provided, but three or more infusion shelves 30 may be provided. For example, when three infusion shelves 30 are provided in the vertical direction, the second transport unit 120 may be controlled as follows.

[0322] Fig. 28 is a diagram for explaining an example of a transport method of the second transport section 120. In Fig. 28, the upper infusion shelf 30 is referred to as the first infusion shelf 30A, the middle infusion shelf 30 is referred to as the second infusion shelf 30B, and the lower infusion shelf 30 is referred to as the third infusion shelf 30C.

[0323] 28, when the shutter 37 is located at a position facing the rear end 362 of any one of the infusion shelves 30, the second transport unit 120 can access the other infusion shelves 30. In this example, when the shutter 37 is located at a position facing the second infusion shelf 30B, the second transport unit 120 can access the first infusion shelf 30A and the third infusion shelf 30C.

[0324] 28, when the second transport unit 120 is in the second infusion shelf 30B, the shutter control unit 148 does not move the shutter 37 covering the third infusion shelf 30C. In this state, even when the shutter 37 covers the first infusion shelf 30A, the shutter control unit 148 does not move the shutter 37.

[0325] On the other hand, as shown by the symbol 2073 in Figure 28, when the second transport section 120 is inserted into the first infusion shelf 30A, the shutter control section 148 may move the shutter 37 between a position facing the second infusion shelf 30B and a position facing the third infusion shelf 30C.

[0326] Therefore, even when the second transport unit 120 is in the first infusion shelf 30A, the shutter control unit 148 can position the shutter 37 at a position facing the second infusion shelf 30B or the third infusion shelf 30C. Therefore, the control unit 140 can unlock the infusion side door 34 of the second infusion shelf 30B or the third infusion shelf 30C, allowing the user to access the second infusion shelf 30B or the third infusion shelf 30C. Cut.

[0327] Furthermore, when the second transport unit 120 is in the third infusion shelf 30C, the shutter control unit 148 may move the shutter 37 between a position facing the first infusion shelf 30A and a position facing the second infusion shelf 30B. Therefore, even when the second transport unit 120 is in the third infusion shelf 30C, the user can access the first infusion shelf 30A or the second infusion shelf 30B in the same manner as described above.

[0328] When the second transport unit 120 is in one of the infusion shelves 30, if the shutter control unit 148 does not move the shutter 37, there is a risk that the user will not be able to access the infusion shelf 30 that he or she wishes to access until the second transport unit 120 moves away from the infusion shelf 30. As described above, even when the second transport unit 120 is in one of the infusion shelves 30, the user can access the infusion shelf 30 that he or she wishes to access by making the shutter 37 movable depending on the position. This increases the possibility of reducing the waiting time of the user accessing the infusion shelf 30.

[0329] <How to remove the infusion container> Fig. 29 is a diagram for explaining an example of a method for removing the infusion container 503. As shown in Fig. 29, the infusion shelf 30 may be provided with a stopper 38. The stopper 38 is a member for regulating the orientation of the infusion container 503 located at the rear end 362. When the infusion container 503 abuts against the stopper 38, the rail portion 36 can hold the infusion container 503 such that the surface of the infusion container 503 is approximately perpendicular to the extension direction of the suction portion 121. The stopper 38 may function as a member for preventing the infusion container 503 located at the rear end 362 from moving in the rear direction.

[0330] The position, shape and size of the stopper 38 are determined so that a part of the infusion container 503 located at the rear end 362 comes into contact with the stopper 38 and does not impede the second transport unit 120 from removing the infusion container 503. In this embodiment, the stopper 38 is provided at the rear end 362 on the plate-like member 301 that defines the bottom of the infusion shelf 30. In addition, the tip of the stopper 38 is inclined toward the rear so that the infusion container 503 can be easily removed.

[0331] When the second transport unit 120 picks up the infusion container 503 and removes the infusion container 503 from the infusion shelf 30, the second transport control unit 145 may move the second transport unit 120 substantially vertically and then substantially parallel to the depth direction, as shown by a path C1 in Fig. 29. Thereafter, the second transport control unit 145 moves the second transport unit 120 to the depth direction and diagonally upward. The respective movement distances of the second transport unit 120 when it moves substantially vertically, when it moves substantially parallel to the depth direction, and when it moves diagonally upward are preset based on, for example, the positional relationship between the rail unit 36 ​​and the stopper 38.

[0332] By controlling the movement of the second transport unit 120 as described above, it is possible to smoothly remove the infusion container 503 without increasing the height of the infusion shelf 30 (while saving the space of the infusion shelf 30).

[0333] [Control when power is off] The control unit 140 stores in a volatile memory the type of the syringe 501 or vial 502 being transported by the first transport unit 110. Therefore, if the power supply of the co-infusion device 1 is turned off due to a power outage or the like while the first transport unit 110 is transporting the syringe 501 or the vial 502, the control unit 140 may not be able to manage whether the equipment held by the first transport unit 110 is the syringe 501 or the vial 502. Therefore, after the power supply is restored, the control unit 140 removes the equipment held by the first transport unit 110 when the power supply was turned off from the first transport unit 110, making it possible to redo the co-infusion operation.

[0334] The co-infusion device 1 may include, for example, a camera that captures the syringe 501 and the vial 502 being transported by the first transport unit 110. The control unit 140 may determine whether the equipment being transported by the first transport unit 110 is the syringe 501 or the vial 502 based on an image captured by the camera during operation of the co-infusion device 1 after power is restored. The control unit 140 performs the above determination, for example, by comparing a silhouette image of the equipment shown in the image with the silhouette images of the syringe 501 and the vial 502 stored in the storage unit 200. As long as the first transport unit 110 can detect the equipment being transported and the control unit 140 can perform the above determination, the member that detects the equipment being transported may be a member other than a camera.

[0335] After the power is restored, if the control unit 140 determines that the object being transported is a syringe 501, the touch panel control unit 150 displays on the touch panel 80 a notification image that prompts the user to remove the syringe 501 from the co-infusion device 1. This is because the needle attached to the syringe 501 being transported by the first transport unit 110 has no needle cap attached, and the needle is exposed. On the other hand, if the control unit 140 determines that the object being transported is a vial 502, the first transport control unit 143 transports the vial 502 to the waste bin unit 70.

[0336] In addition, the control unit 140 stores in a volatile memory the type of the infusion container 503 being transported by the second transport unit 120. Therefore, if the power supply of the co-infusion device 1 is turned off due to a power outage or the like while the second transport unit 120 is transporting the infusion container 503, the control unit 140 may not be able to manage the type of the infusion container 503 held by the second transport unit 120. Therefore, after the power supply is restored, the control unit 140 removes the infusion container 503 held by the co-infusion unit 40 when the power supply was turned off from the co-infusion unit 40, so that the co-infusion operation can be redone.

[0337] After the power is restored, the second transport control unit 145 may transport the second transport unit 120 to a position facing the infusion container 503 held in the mixing unit 40. Then, the control unit 140 may specify the type (size) of the infusion container 503 by having the third reading unit 122 read information on the first label attached to the infusion container 503.

[0338] As described above, information associating the type of the infusion container 503 with the suction unit 121 used to suction the infusion container 503 is stored in the storage unit 200. Therefore, the control unit 140 specifies the type of the infusion container 503 held in the mixing unit 40, thereby specifying the suction unit 121 used to suction the infusion container 503. This allows the second transport unit 120 to transport the infusion container 503 to the infusion receiving shelf 60, so that the user can take out the infusion container 503 stored in the infusion receiving shelf 60.

Claims

1. an injection unit that injects a portion of the infusion solution contained in the syringe into a medicine container containing powdered medicine; an extracting unit that extracts the infusion liquid containing the powdered medicine from the medicine container into which the infusion liquid has been injected by the injecting unit using a syringe; A co-infusion device comprising: a mixing unit that mixes the infusion liquid extracted by the extraction unit with the remaining infusion liquid that was not injected into the drug container by the injection unit.

2. The injection device described in Claim 1, wherein the injection section injects a portion of the mixed infusion into the drug container.

3. 2. The co-infusion device according to claim 1, wherein the extraction unit extracts the infusion solution containing dissolved powdered medicine from the drug container into which the injection unit injected the infusion solution using the same syringe as the syringe into which the injection unit injected the infusion solution, thereby realizing the operation of the mixing unit.

4. The co-infusion device according to claim 1, wherein the injection unit injects the infusion solution contained in the syringe into the drug container with the tip of the needle of the syringe facing upward and puncturing the stopper of the drug container.

5. 5. The co-infusion device according to claim 4, further comprising a tilting portion that tilts the drug container so that the stopper faces downward from a first state to a second state facing a horizontal surface after the injection portion has injected the infusion into the drug container.

6. The co-infusion device according to claim 5 , wherein the tilting portion tilts the drug container so that the stopper is in a third state facing downward more than in the second state.

7. The extraction unit is After the infusion unit extracts the infusion liquid containing dissolved powdered medicine from the medicine container into which the infusion liquid has been injected, the infusion liquid containing dissolved powdered medicine is extracted again from the medicine container after a predetermined time has elapsed, or The co-infusion device according to claim 1, wherein the injecting unit uses a syringe to remove gas from the medicine container into which the infusion liquid has been injected, and then removes the infusion liquid in which the powdered medicine has been dissolved after a predetermined time has elapsed.

8. A co-infusion device that co-injects a drug contained in a drug container into an infusion contained in an infusion container, A co-infusion device comprising a first determination unit that determines whether a syringe that extracts an infusion contained in the infusion container, a syringe that injects a liquid medicine or infusion into the infusion container, a syringe that extracts a liquid medicine or infusion contained in the medicine container, or a syringe that injects an infusion into the medicine container is a medium-mouth type syringe or a side-mouth type syringe.

9. a holder for holding the syringe; The co-infusion device according to claim 8, wherein the first determination unit determines whether the syringe held in the holding unit is a medium-mouth syringe or a side-mouth syringe.

10. The co-infusion device according to claim 9, further comprising a second determination unit that determines whether the side-mouth type syringe is properly attached to the holder.

11. The co-infusion device according to claim 9 or 10, wherein the holding part is a member capable of holding the syringe to be loaded into the co-infusion device.

12. A co-infusion device that co-injects a drug contained in a drug container into an infusion contained in an infusion container, A co-infusion device comprising an adjustment unit that adjusts the amount of needle puncture into the stopper of the medicine container or the stopper of the infusion container, or the puncture position of the needle in the stopper of the medicine container or the stopper of the infusion container, depending on the type of needle attached to the syringe that extracts the infusion contained in the infusion container, the syringe that injects the liquid medicine or infusion into the infusion container, the syringe that extracts the liquid medicine or infusion contained in the medicine container, or the syringe that injects the infusion into the medicine container.

13. a detection unit that detects the needle; a discrimination unit that discriminates the type of the needle based on the detection result of the detection unit, The co-infusion device according to claim 12, wherein the adjustment unit adjusts the needle puncture amount or the needle puncture position according to the type of the needle determined by the determination unit.

14. The types of needles include a first needle having a tip end portion of the needle with a first inclination angle and a second needle having a second inclination angle that is larger than the first angle, The co-infusion apparatus according to claim 12 or 13, wherein the adjustment unit reduces the puncture depth of the needle when the type of the needle is the second needle compared to when the type of the needle is the first needle.

15. a mixing unit that mixes and injects a drug contained in a drug container into an infusion solution contained in an infusion solution container; The co-infusion unit includes a pair of moving units that move between positions close to each other and positions spaced apart from each other, Each of the pair of moving parts has a clamping portion that clamps the needle of the syringe used for co-infusion at the positions close to each other, and a non-clamping portion other than the clamping portion, The clamping portion is an insulating member, and at least a portion of the non-clamping portion has a conductive member.

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