Implantation type manually controlled drug delivery device

Abstract

To provide an implantation type manually controlled drug delivery device including a manually controlled drive pump that enables dosage of a constant quantity of drug at a time desired by a patient.SOLUTION: An implantation type manually controlled drug delivery device is convenient in adjusting a medication schedule since drug can be subjected to precisely controlled delivery in the outside after implantation is performed by adjusting a concentration of the drug and an internal volume and a drive frequency of a drug chamber 22. Since a battery is unnecessary and an internal adjustment device for electromagnetic control is unnecessary, the device is friendly to patients and economical.SELECTED DRAWING: Figure 1

Description

[Technical field]

[0001] The present invention relates to implantable drug delivery technology, and more particularly to an implantable drug delivery device having a manually controlled actuated pump that allows a patient to administer a fixed amount of drug at a time desired by the patient. [Background technology]

[0002] Patients suffering from chronic diseases such as cancer, brain diseases, diabetes, or osteoporosis require long-term, continuous drug therapy for treatment. One type of drug therapy is called chronotherapy, which involves precisely injecting drugs at specific times to increase drug absorption and minimize side effects. Specifically, chronotherapy uses 1) oral administration, 2) injections, and 3) implantable devices.

[0003] Among these, oral administration has the disadvantage that drugs used for chronic diseases are denatured or inactivated as they pass through the gastrointestinal tract, resulting in low bioavailability and severe side effects due to exposure of the drug to the gastrointestinal tract. Injections are effective, but patients are subject to a lot of stress due to the increased number of administrations required to maintain the drug concentration in the blood for a long time. In addition, implantable devices that deliver drugs through diffusion and release them over a long period of time are capable of delivering drugs, but they have problems such as the rapid release of drugs immediately after implantation and the inability to control the amount of drug released after implantation. Implantable devices that overcome these problems are equipped with batteries and electronic circuits to control drug release, which increases their volume and may require additional implantation surgery due to the problem of replacing the battery.

[0004] US Patent Publication No. 7052488 is about an implantable drug delivery device, and discloses a tunable pulsed drug delivery technology based on multiple drug reservoirs. Each drug reservoir is filled with drug, and gold foil is sealed on top of it, and the gold foil is mechanically ruptured to release the drug. However, this device has problems in that it requires additional components such as a controller and battery inside the device to rupture the gold foil, which increases the device's volume, and it is not possible to reinject the drug.

[0005] Therefore, in order to overcome these problems, there is a need for the development of an implantable drug delivery device that can be miniaturized because it does not require internal additional devices and batteries, and that can precisely control the drug dosage and schedule according to the patient's needs externally even after implantation in the body.

[0006] Prior art documents

[0007] Patent Literature

[0008] (Patent Document 0001) U.S. Patent Publication No. 7,052,488 Summary of the Invention [Problem to be solved by the invention]

[0009] The present invention aims to solve the above-mentioned problems by providing a drug delivery device that does not require any internal additional devices or batteries, can be made small, and is manually controlled so that the patient can control the drug dosage and schedule externally even after implantation in the body. [Means for solving the problem]

[0010] The present invention provides an implantable manually controlled drug delivery device, comprising: a drug storage unit for filling and storing a drug; a drug release driver for releasing a predetermined amount of the drug from the drug storage unit to the outside of the device through the movement of a manually controlled button; and a housing in which the drug storage unit and the drug release driver are stacked to form the external form of the device. A space in the housing where the drug storage unit is stacked is formed with a drug inlet and a drug delivery port, and a space in the housing where the drug release driver is stacked is a drive pump space having an opening for the up and down movement of a drive pump for pumping a drug, and a predetermined amount of drug is filled and then released by the pumping. The device includes a drug chamber space, and the drug release driving unit includes an inlet valve connecting the drug storage unit and the drug chamber space, a drug chamber connected to one end of the inlet valve, an outlet valve connecting the drug chamber and a drug outlet, and a driving pump connected to the manual control button to apply pressure to the drug chamber, and the driving pump releases the drug in the drug chamber to the outside of the device through the outlet valve and the drug outlet in response to the movement of the manual control button, and fills the drug in the drug storage unit into the drug chamber through the inlet valve.

[0011] The present invention also provides an implantable manually controlled drug delivery device, wherein the drive pump includes a piston in contact with the drug chamber; a spring applying a restoring force to a position where the piston does not apply pressure to the drug chamber; and a manually controlled button movable against the restoring force of the spring to a position where the spring applies pressure to the drug chamber.

[0012] The present invention also provides an implantable manually controlled drug delivery device, wherein the driving pump further includes a piston driving force control section, the piston driving force control section including: a notch formed in a housing fixing section supporting a piston; a guide window formed to be inclined on the manual control button; a latch which passes through the notch and moves along the guide window, and is formed on the piston in a direction perpendicular to the piston movement direction, thereby controlling the movement of the piston according to the direction of the notch; an internal spring which constitutes the spring, and when the manual control button is pressed, the latch moves horizontally at the notch while moving along the guide window, and pushes down the piston when it reaches a broken portion of the notch; and an external spring which constitutes the spring, and when the pressing force of the manual control button is removed, the position of the manual control button is returned to its original state, and in the process, the latch moves vertically at the notch while moving along the guide window, and when it reaches a broken portion of the notch, it moves horizontally to return the latch to the position before the pressing force was applied.

[0013] The present invention also provides an implantable manually controlled drug delivery device, wherein the drug storage portion comprises a drug storage cylinder for delivering the drug injected into the drug inlet to the inlet valve.

[0014] The present invention also provides an implantable manually controlled drug delivery device, wherein the housing integrally includes a drug storage tube, a drug injection port connecting tube and an inlet valve connecting tube in the drug storage space, and integrally includes the inlet valve and the outlet valve in the drug release driving space.

[0015] The present invention also provides an implantable manually controlled drug delivery device, wherein the spring-driven pump releases drug when pumped up and down.

[0016] The present invention also provides an implantable multiple-control drug delivery device, wherein the drug storage section and the drug release driving section are arranged in parallel to each other inside the housing, and the drug delivery port, the inlet valve, the drug chamber and the outlet valve are arranged in a straight line.

[0017] The present invention also provides a method for manufacturing a drug delivery device, comprising the steps of: disposing the drug delivery port, the inlet valve, and the drug chamber in a line; connecting the drug chamber and the outlet valve in different directions; and

[0018] An implantable, manually controlled drug delivery device is provided. Effect of the Invention

[0019] The device of the present invention can precisely control and deliver drugs externally after implantation by adjusting the drug concentration, the internal volume of the drug chamber, and the number of times of operation, making it easy to adjust the drug administration schedule. In addition, it is economical because it does not require an external power source such as a battery or an internal adjustment device for electromagnetic control. In addition, as long as it is pressed to a certain depth or more, the piston can be pushed out with the same pressure at all times, so that a fixed amount of drug can be released. [Brief description of the drawings]

[0020] [Figure 1] 1 is a conceptual diagram of an implantable manually controlled drug delivery device according to a first embodiment of the present invention.

[0021] [Diagram 2] FIG. 2 is a conceptual diagram showing the drug release drive of the implantable manually controlled drug delivery device according to the first embodiment of the present invention.

[0022] [Diagram 3] 1 shows the actual shape of an implantable manually controlled drug delivery device according to a first embodiment of the present invention.

[0023] [Figure 4] 1 is a conceptual diagram showing the external appearance of an implantable manually controlled drug delivery device according to a first embodiment of the present invention.

[0024] [Diagram 5]FIG. 1 is a schematic diagram showing the disassembled components of an implantable manually controlled drug delivery device according to a first embodiment of the present invention.

[0025] [Figure 6] 1 is a conceptual diagram showing an internal cross section of an implantable manually controlled drug delivery device according to a first embodiment of the present invention.

[0026] [Figure 7] FIG. 2 is a conceptual diagram of an implantable manually controlled drug delivery device according to a second embodiment of the present invention.

[0027] [Figure 8] FIG. 13 is a conceptual diagram showing the drug release drive of an implantable manually controlled drug delivery device according to a second embodiment of the present invention.

[0028] [Figure 9] FIG. 11 is a conceptual diagram showing the drug release drive of an implantable manually controlled drug delivery device having a piston driving force control function according to a second embodiment of the present invention.

[0029] [Figure 10] FIG. 11 is an exploded perspective view of a piston driving force control function portion according to a second embodiment of the present invention.

[0030] [Figure 11] 1 is a graph showing the correlation between the amount of drug delivered and the number of times the implantable manually controlled drug delivery device of the present invention is used. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0031] Prior to the detailed description of the present invention, the terms and words used in the following specification and claims should not be interpreted as being limited in their ordinary or dictionary sense. Therefore, the embodiments described in this specification and the configurations illustrated in the drawings are merely the most preferred embodiments of the present invention and do not represent the entire technical idea of ​​the present invention, so it should be understood that there may be various equivalents and modifications that can replace them at the time of this application.

[0032] Hereinafter, the present invention will be described with reference to the accompanying drawings, in which:

[0033] 1 to 6 are conceptual diagrams of an implantable manually controlled drug delivery device having a parallel structure according to a first embodiment of the present invention. FIG. 1 is a conceptual diagram of an implantable manually controlled drug delivery device in which a drug storage unit and a drug release drive unit of the implantable manually controlled drug delivery device of the present invention are arranged in parallel. FIG. 2 is a conceptual diagram showing the drug release drive of the implantable manually controlled drug delivery device of the first embodiment of the present invention. The implantable manually controlled drug delivery device according to one embodiment of the present invention includes a drug storage unit 10 for filling and discharging a drug; a drug release drive unit 20 for releasing a drug from the drug storage unit in a predetermined amount outside the device; and a housing 30 in which the drug storage unit and the drug release drive unit are spatially separated and stacked adjacent to each other inside, forming the external form of the device. In one embodiment of the present invention, the drug storage unit 10 and the drug release drive unit 20 are arranged in parallel with each other inside the housing, and the drug delivery port, the inlet valve, the drug chamber, and the outlet valve may be arranged in a straight line.

[0034] The drug storage section 10 of the housing 30 according to one embodiment of the present invention is a space for filling and storing a drug, and may have a drug inlet 11 on an outer wall and a drug delivery port 15 on an inner wall facing the drug release driver. The space in which the drug release driver 20 of the housing is placed includes a drive pump space having an opening for vertical movement for pumping the drug delivered from the drug delivery port 15, and a drug chamber 22 space for filling a predetermined amount of drug by the pumping and then releasing it to the outside. In one embodiment of the present invention, the drug inlet 11 may protrude from the housing 30 so that the drug can be injected even after the device is implanted in the body.

[0035] The drug storage unit 10 in one embodiment of the present invention includes a drug reservoir 13 that receives drug from the drug injection port 11 and transmits the drug to the drug transmission port 15, a drug injection port connecting pipe 12 that connects the drug injection port 11 and the drug storage reservoir 13, and a drug transmission port connecting pipe 14 that connects the drug storage reservoir 13 and the drug transmission port 15.

[0036] The drug release driving unit 20 includes an inlet valve 21 connected to the drug delivery port 15 so that the drug can proceed in one direction, a drug chamber 22 connected at one end to the drug outlet of the inlet valve, an outlet valve 23 connecting the drug outlet 16 through which the drug is released from the drug chamber to the outside of the device, and a spring-driven pump 25 that applies pressure to the drug chamber 22 to release the drug in the drug chamber to the outlet valve 23 and removes the pressure applied to the chamber to fill the drug in the drug chamber 22 from the inlet valve 21. The driving pump can release the drug in the drug chamber 22 to the outside of the device through the outlet valve 23 and the drug outlet 16 and fill the drug in the drug storage unit 10 to the drug chamber 22 through the inlet valve 21 by the movement of a manual control button. In one embodiment of the present invention, the inlet valve 21 and the outlet valve 23 are funnel-shaped to allow the drug to flow in one direction, and may be provided with a backflow prevention membrane at the drug outlet to prevent the drug from flowing in the opposite direction to the forward direction.

[0037] The housing in one embodiment of the present invention may include the drug storage cylinder 13, the drug main inlet connecting pipe 12 and the drug outlet connecting pipe 14 integrated into the drug storage section 10 space, and may include the inlet valve 21 and the outlet valve 23 integrated into the drug release driving section space.

[0038] The spring-driven pump (actuator) 25 according to one embodiment of the present invention includes a piston 26 in contact with the drug chamber 22, a spring 27 that applies a restoring force to the position where the piston does not apply pressure to the drug chamber, and a manual control button 28 that moves the spring to a position where it applies pressure to the drug chamber against the restoring force of the spool. The drug release process through the operation of the spring-driven pump 25 is as follows: (1) when the manual control button 28 is pressed, (2) the piston 26 inside the spring-driven pump 25 moves downward to push out the drug filled in the drug chamber 22, and (3) the drug is released to the outside through the drug outlet 16 by the outlet valve 23. Then, (4) the piston 26 returns to its original position by the restoring force of the spring 27, and at this time, the drug in the drug storage tube 13 is refilled into the drug chamber 22 through the inlet valve 21.

[0039] In a first embodiment of the present invention, the driving pump further includes a piston driving force control unit, and the piston driving force control unit may include: a notch formed in a housing fixing part supporting a piston; a guide window formed to be inclined toward the manual control button; a latch that passes through the notch and moves along the guide window, and is formed on the piston in a direction perpendicular to the piston movement direction to control the movement of the piston according to the direction of the notch; an internal spring that constitutes the spring, and when the manual control button is pressed, the latch moves horizontally at the notch while moving along the guide window and then reaches a broken portion of the notch to push down the piston; and an external spring that constitutes the spring, and when the pressing force of the manual control button is removed, the position of the manual control button is returned to its original state, and in the process, the latch moves vertically at the notch while moving along the guide window, and then moves horizontally when it reaches a broken portion of the notch to return the latch to a position before the pressing force was applied.

[0040] Fig. 3 shows the actual shape of the implantable manually controlled drug delivery device according to the first embodiment of the present invention, and Fig. 4 shows the external appearance of the implantable manually controlled drug delivery device according to the first embodiment of the present invention. Fig. 5 shows the disassembled state of the components of the implantable manually controlled drug delivery device according to the first embodiment of the present invention, and Fig. 6 shows the internal cross section of the implantable manually controlled drug delivery device according to the first embodiment of the present invention. The actual structures corresponding to each component part of Figs. 1 and 2 are shown with the drawing numbers.

[0041] 7 to 10 are conceptual diagrams of an implantable manually controlled drug delivery device according to a second embodiment of the present invention, which relates to a serial drug delivery device. FIG. 7 is a conceptual diagram of an implantable manually controlled drug delivery device in which a drug storage unit and a drug release driving unit are arranged in series. In one embodiment of the present invention, the drug storage unit 110 and the drug release driving unit 120 are arranged in series inside the housing 130, the drug delivery port 115, the inlet valve 121, and the drug chamber 122 are arranged in a straight line, and the directions of connecting the drug chamber 122 and the outlet valve 123 may be formed in different directions. In one embodiment, the direction of connecting the drug delivery port 115, the inlet valve 121, and the drug chamber 122 and the direction of connecting the drug chamber 122 and the outlet valve 123 may be perpendicular to each other, and the drug outlet directions of the inlet valve 121 and the outlet valve 123 may also be perpendicular to each other. 8 is a conceptual diagram showing the drug release drive of an implantable manually controlled drug delivery device according to a second embodiment of the present invention. The implantable manually controlled drug delivery device according to one embodiment of the present invention includes a drug storage unit 110 for filling and discharging drugs, a drug release drive unit 120 for releasing the drug from the drug storage unit in predetermined amounts outside the device, and a housing 130 in which the drug storage unit and the drug release drive unit are spatially separated and stacked adjacent to each other inside, forming the external form of the device.

[0042] According to one embodiment of the present invention, the space in which the drug storage unit 110 of the housing 130 is placed includes a drug inlet 111 on an outer wall surface and a drug delivery port 115 on an inner wall surface facing the drug release driver, and the space in which the drug release driver 120 of the housing is placed includes a drive pump space having an opening for vertical movement to pump the drug delivered from the drug delivery port 115, and a drug chamber 122 space that fills a predetermined amount of drug by pumping and then releases it. In one embodiment of the present invention, the drug inlet 111 may protrude from the housing 130 so that the drug can be injected even after the device is implanted in the body.

[0043] The drug reservoir 110 according to an embodiment of the present invention includes a drug reservoir 113 for receiving a drug from the drug inlet 111 and delivering the drug to the drug delivery port 115, a drug inlet connection pipe 112 for connecting the drug inlet 111 and the drug reservoir 113, and a drug delivery port connection pipe 114 for connecting the drug reservoir 113 and the drug delivery port. The drug release driver 120 includes an inlet valve 121 connected in series with the drug delivery port 115 to allow the drug to travel in one direction, a drug chamber 122 having one end connected to the drug outlet of the inlet valve, an outlet valve 123 for connecting the drug chamber and the drug delivery port 116, and a spring-driven pump 125. The spring-driven pump applies pressure to the drug chamber 122 to transfer the drug in the drug chamber to the outlet valve 123 and release it to the outside of the device through the drug outlet 116, and removes the pressure applied to the chamber to fill the drug chamber 122 with drug through the inlet valve 121. The inlet valve 121 and the outlet valve 123 according to one embodiment of the present invention are funnel-shaped to allow the drug to flow in one direction, and may be provided with a backflow prevention membrane at the drug outlet to prevent the drug from flowing in the opposite direction to the forward direction.

[0044] The housing according to one embodiment of the present invention may integrally include the drug storage cylinder 113, the drug inlet connecting pipe 112, and the drug delivery port connecting pipe 114 in the drug storage section 110 space, and may integrally include the inlet valve 121 and the outlet valve 123 in the drug release actuator space. The spring-driven pump (actuator) 125 according to one embodiment of the present invention includes a piston 126 in contact with the drug chamber 122, a spring 127 that applies a restoring force to a position where the piston does not apply pressure to the drug chamber, and a manual control button 128 that moves the spring to a position where it applies pressure to the drug chamber against the restoring force of the spring.

[0045] The drug release process through the operation of the spring driven pump 25 is as follows: (1) When the manual control button 128 is pressed, (2) the piston 126 inside the spring driven pump 125 moves downward to push out the drug filled in the drug chamber 122, and (3) the drug is released to the outside through the outlet valve 123. Then, (4) the piston 126 returns to its original position due to the restoring force of the spring 127, and at this time, the drug in the drug storage cylinder 113 is refilled into the drug chamber 122 through the inlet valve 121.

[0046] Figure 9 is a conceptual diagram showing the drug release drive of an implantable manually controlled drug delivery device having a piston driving force control function according to the second embodiment of the present invention, and Figure 10 is an exploded oblique view of the piston driving force control function part according to the second embodiment of the present invention. In one embodiment of the present invention, the spring driven pump further includes a piston driving force control unit, which includes a notch 220 formed in the shape of a "┐" on a housing fixing portion supporting a piston; a guide window 200 formed to be inclined on the manual control button; a latch 210 which passes through the notch and moves along the guide window, and is formed on the piston in a direction perpendicular to the piston movement direction to control the movement of the piston according to the direction of the notch; an inner spring 127-2 which constitutes the spring and which, when the manual control button is pressed, moves the latch horizontally at the notch while moving along the guide window and then reaches a broken portion of the notch to push down the piston; and an outer spring 127-1 which, when the pressing force on the manual control button is removed, returns the position of the manual control button to its original state, and in the process, the latch moves vertically at the notch while moving along the guide window and then moves horizontally when it reaches a broken portion of the notch to return the latch to its position before the pressing force was applied.

[0047] In one embodiment of the present invention, the manual control button 128 of the spring-driven pump 125 is not driven unless it is pressed to a predetermined depth or more, and the piston 126 can be pushed out with the same force only when it is pressed to the predetermined depth or more. For this purpose, the spring 127 of the spring-driven pump 125 includes an outer spring 127-1 and an inner spring 127-2, and the outer spring 127-1 returns the manual control button 128 to its original state, and the inner spring 127-2 pushes down the piston 126. The piston 126 has a latch 210 formed in a direction perpendicular to the piston movement direction, and when the piston is not driven, the latch 210 is engaged with a notch 220 of a housing fixing part that supports the piston, so that even if the inner spring 127-2 pushes the piston, the piston does not move and does not apply pressure to the drug chamber 122. The operation principle will be described below.

[0048] 9 shows in detail the drug release actuation process of the implantable manually controlled drug delivery device with piston actuation force control function. The latch 210 protrudes through the notch 220 and is restricted in position so that it can only move along the guide window 200 formed at an angle on the manual control button 128. (a) When the manual control button 128 is pressed, (b) the internal spring 127-2 is compressed, but (c) the latch 210 moves along the guide window 200 but cannot deviate from the horizontal direction of the notch 220, so that the piston 126 cannot apply pressure to the drug chamber 122. The piston 126 remains unable to apply pressure to the drug chamber 122 due to the latch until the upper surface position of the manual control button 128 moves from A to B. (d) When the latch 210 continues to move along the guide window 200 and the upper surface position of the manual control button 128 passes B, the latch 210 reaches the vertical opening of the notch, the internal spring is released from the movement restriction, and the piston 126 starts to move, and the piston always applies a uniform pressure to the drug chamber 122 with the same force. (e) When the drug chamber is pressurized, a fixed amount of drug is released to the outlet valve 123. (h) When the hand is released from the manual control button 128, (g) the piston 126 returns due to the force of the external spring 127-1 being pressed and then restored, and (f) the drug is filled again as the inlet valve 121 is opened. During this process, (i) the latch 210 moves along the guide window 200 and moves along the horizontal direction of the notch 200. Through the above operation, the spring-driven pump 125 with driving force control function will not operate unless it is pressed to a certain depth or more, and as long as it is pressed to a certain depth or more, it is possible to always push the piston with the same pressure, thereby enabling the drug to be released in a fixed amount.

[0049] Working Example

[0050] 11 is a graph showing the correlation between the amount of drug delivered and the number of times the device is used. To test the performance of the device, the drug injection performance was tested in an experimental setting (in vitro) rather than in a state where the device was inserted into the body. As a result of testing the amount of drug injected according to the number of manually controlled compressions, it was confirmed that 10±1 μl of drug was injected per compression.

[0051] The device of the present invention can be implanted into various body parts or tissues of an animal, e.g., a mammal, either in the body part itself in need of treatment or in a part capable of communicating to other parts through the body's functions, e.g., subcutaneously, intramuscularly, or in an organ, abdomen, or arm area.

[0052] Thus, the device of the present invention can be implanted at various sites in an animal to deliver drugs, and in another aspect, the present invention also relates to a method for delivering drugs to a body site or tissue of an animal using the drug delivery device of the present invention.

[0053] Although the exemplary embodiments of the present invention have been described in detail above, the scope of the present invention is not limited thereto, and various modifications and improvements made by those skilled in the art using the basic concept of the present invention defined in the claims below also fall within the scope of the present invention.

[0054] Unless otherwise defined, all technical terms used in the present invention are used in the same meaning as commonly understood by a person of ordinary skill in the art in the relevant field of the present invention. The contents of all publications mentioned as references in this specification are incorporated herein by reference. [Explanation of symbols]

[0055] 10, 110: Drug storage section

[0056] 11, 111: Drug injection port

[0057] 12, 112: drug injection port connecting tube

[0058] 13, 113: Drug storage cylinder

[0059] 14, 114: Drug delivery port connecting tube

[0060] 15, 115: Drug delivery port

[0061] 16, 116: Drug outlet

[0062] 20, 120: Drug release drive unit

[0063] 21, 121: Inlet valve

[0064] 22, 122: Drug chamber

[0065] 23, 123: Outlet valve

[0066] 25, 125: Spring-driven pump

[0067] 26, 126: Piston

[0068] 27, 127: Spring

[0069] 127-1: External spring

[0070] 127-2: Internal spring

[0071] 200: Guide window

[0072] 210: Bet

[0073] 220:Notch

[0074] 28, 128: Manual control buttons

[0075] 30, 130: Housing

[0076] (1) Press the manual control button (28, 128)

[0077] (2) The piston (26, 126) moves downward.

[0078] (3) Drug release to outlet valve (23, 123)

[0079] (49) The restoring force of the spring (27, 127) recharges the drug chamber (22, 122).

[0080] (a) Pressing the manual control button 128

[0081] (b) Inner spring 127-2 is crimped together

[0082] (c) the latch 210 moves along the guide window 200 but cannot deviate from the horizontal orientation of the notch 220, so that the piston 126 cannot apply pressure to the medication chamber 122;

[0083] (d) When the latch 210 continues to move along the guide window 200 and the upper surface position of the manual control button 128 passes B, the latch 210 reaches the vertical opening of the notch, the internal spring is released from the movement restriction, and the piston 126 starts to move, and the piston always applies a uniform pressure to the drug chamber 122 with the same force.

[0084] (e) When the drug chamber is pressurized, it releases a fixed amount of drug into the outlet valve 123.

[0085] (f) Inlet valve 121 is opened and refilled with drug.

[0086] (g) The piston 126 returns to its original position due to the force of the external spring 127-1 being pressed.

[0087] (h) Release the manual control button 128

[0088] (i) The latch 210 moves along the guide window 200 while moving in the horizontal direction of the notch 200.

Claims

1. 1. An implantable manually controlled drug delivery device comprising: The device comprises a drug reservoir for loading and storing a drug; a drug release driver for releasing the drug from the drug reservoir in predetermined amounts out of the device through the movement of a manual control button; and The drug storage unit and the drug release drive unit are stacked inside a housing that constitutes an external form of the device, The space in the housing where the drug storage unit is placed is provided with a drug inlet and a drug delivery port, The space in the housing where the drug release driving unit is installed includes a driving pump space having an opening for vertical movement of a driving pump for pumping a drug, and a drug chamber space which is filled with a predetermined amount of drug by the pumping and then released, the drug release driving unit includes an inlet valve connecting the drug storage unit and a drug chamber space, a drug chamber connected to one end of the inlet valve, an outlet valve connecting the drug chamber and a drug outlet, and a driving pump connected to the manual control button to apply pressure to the drug chamber; The drive pump is a piston (126) in contact with the medication chamber; a spring (127) that exerts a restoring force on the piston to a position where it exerts no pressure on the drug chamber; a manual control button (128) operable to move the spring to a position where it applies pressure to the medication chamber against the restoring force of the spring; and a notch (220) formed in the housing fixing part supporting the piston; a guide window (200) formed inclined on the manual control button; a latch (210) that passes through the notch and moves along the guide window, and is formed on the piston in a direction perpendicular to the piston movement direction to control the movement of the piston along the direction of the notch; an internal spring (127-2) that constitutes the spring and that, when the manual control button is pressed, the latch moves along the guide window, and when it reaches the broken portion of the notch after moving horizontally in the notch, pushes down the piston; and and an external spring (127-1) which constitutes the spring and returns the position of the manual control button to its original state when the pressing force is removed from the manual control button, and in the process, the latch moves along the guide window, moves vertically at the notch, and when it reaches the broken portion of the notch, moves horizontally to return the latch to the position before the pressing force was applied, The driving pump releases the drug in the drug chamber to the outside of the device through the outlet valve and the drug outlet by the movement of the manual control button, and fills the drug in the drug storage section into the drug chamber through the inlet valve, thereby forming an implantable manually controlled drug delivery device.

2. 2. The implantable manually controlled drug delivery device of claim 1, wherein the drug storage unit comprises a drug storage tube for delivering the drug injected into the drug inlet to the inlet valve.

3. the housing includes a drug storage cylinder, a drug injection port connecting pipe, and an inlet valve connecting pipe in a space of the drug storage part, the drug storage cylinder being integral with the drug injection port connecting pipe; The implantable manually controlled drug delivery device according to claim 1 , wherein the inlet valve and the outlet valve are integrally included in the space of the drug release drive unit.

4. 2. The implantable manually controlled drug delivery device of claim 1, wherein the driving pump releases the drug when it moves up and down.

5. The drug storage unit and the drug release driver are arranged in parallel with each other inside the housing, 2. The implantable manually controlled drug delivery device of claim 1, wherein the drug delivery port, the inlet valve, the drug chamber and the outlet valve are arranged in a straight line.

6. the drug storage portion and the drug release driver are disposed in series with each other within the housing; The implantable manually controlled drug delivery device of claim 1 , wherein the drug delivery port, the inlet valve, and the drug chamber are arranged in a straight line, and the directions connecting the drug chamber and the outlet valve are formed in different directions from each other.

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