Composition

Abstract

To provide means to suppress stickiness even when a certain amount of dipotassium glycyrrhizinate is blended.SOLUTION: There is provided a composition comprising (A) dipotassium glycyrrhizinate and (B) a polyhydric alcohol, wherein the content of (A) is 0.2 to 1.0 mass% based on the total amount of the composition and (B) is one or two or more selected from 1,3-propanediol, cyclohexylglycerin, isopentyl diol, polyoxyethylene (24) polyoxypropylene (24) glyceryl ether and PEG-400.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to a composition containing dipotassium glycyrrhizinate. [Background technology]

[0002] Dipotassium glycyrrhizinate has an anti-inflammatory effect and is a component that is widely used in skin external preparations to improve rough skin, etc. It is also known as an ingredient that improves wrinkles, one of the symptoms of aging, and is incorporated into skin external preparations such as cosmetics (Patent Document 1). [Prior art documents] [Patent documents]

[0003] [Patent Document 1] JP 2019-108278 A Summary of the Invention [Problem to be solved by the invention]

[0004] Compositions containing dipotassium glycyrrhizinate tend to feel sticky. In view of the above circumstances, an object of the present invention is to provide a means for suppressing stickiness even when a certain amount of dipotassium glycyrrhizinate is blended. [Means for solving the problem]

[0005] The present inventors conducted studies to solve the above problems and found that the above problems can be solved by combining dipotassium glycyrrhizinate with a specific polyhydric alcohol, thereby completing the present invention. That is, the present invention is as follows.

[0006] [1] A composition comprising (A) dipotassium glycyrrhizinate and (B) a polyhydric alcohol, wherein the content of (A) is 0.2 to 1.0 mass% of the total composition, and (B) is one or more selected from 1,3-propanediol, cyclohexylglycerin, isopentyldiol, polyoxyethylene (24) polyoxypropylene (24) glyceryl ether, and PEG-400. [2] The composition according to [1], wherein the content of (B) is 0.01 to 20 mass % based on the total mass of the composition. [3] The composition according to [1] or [2], wherein the mass ratio of the contents of the components (A) and (B) is 1:75 to 20:1. [4] The composition described in any one of [1] to [3], which is an external preparation for skin. Effect of the Invention

[0007] According to the present invention, a composition can be provided in which the sticky feeling is suppressed even when a certain amount of dipotassium glycyrrhizinate is blended. Furthermore, the composition of the present invention suppresses squeaking sensation and provides a moist / fresh feeling, and therefore provides an excellent feel when applied to the skin. Furthermore, in the composition of the present invention, precipitation of crystals of dipotassium glycyrrhizinate is also suppressed. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0008] The present invention will now be described. The composition of the present invention contains (A) dipotassium glycyrrhizinate and (B) a polyhydric alcohol.

[0009] (A) Dipotassium glycyrrhizinate may be an artificially synthesized product or may be obtained from a natural product such as a plant. Dipotassium glycyrrhizinate may also be provided in the form of a plant extract containing the same.

[0010] Dipotassium glycyrrhizinate may be a commercially available product, or may be extracted from, for example, a plant of the genus Glycyrrhiza of the family Leguminosae. The species include Spanish licorice (G. glabra), Ural licorice (G. uralensis), Examples include G. inflata.

[0011] The method of extracting dipotassium glycyrrhizinate from a plant of the genus Glycyrrhiza of the family Leguminosae is not particularly limited, and may be a conventional extraction method, that is, a 1-20-fold amount of water or a lower alcohol such as ethanol is added to the plant body or a processed product thereof as a solvent, and the mixture is stirred as required, and immersed for several days at room temperature or for several hours at a temperature near the boiling point, and insoluble matter is removed by filtration or the like, and then the solvent is removed by distillation under reduced pressure or the like as required, and the mixture may be purified and fractionated by column chromatography or the like, and used. A preferable example of a plant part for preparing a plant extract is, for example, an underground stem.

[0012] In the composition of the present invention, the content of component (A) is 0.2 to 1.0% by mass based on the entire composition. Within this range, stickiness is unlikely to occur, and excellent usability such as a squeaky feeling, a moist feeling, and a fresh feeling is easily obtained, and crystal precipitation is also suppressed. If the content of component (A) is less than 0.2% by mass, the desired effect is difficult to obtain, and if it exceeds 1.0% by mass, the desired effect is not obtained or the freedom of formulation of the composition is impaired. In addition, the content of component (A) may be 0.2% by mass or more, 0.3% by mass or more, or 0.5% by mass or more based on the entire composition, and may be 1.0% by mass or less, 0.8% by mass or less, or 0.7% by mass or less, or a combination thereof that is not contradictory. In addition, the content of component (A) may be 0.2 to 1.0% by mass, 0.3 to 0.8% by mass, or 0.5 to 0.7% by mass based on the entire composition.

[0013] The polyhydric alcohol (B) contained in the composition of the present invention is selected from 1,3-propanediol, cyclohexylglycerin, isopentyldiol, polyoxyethylene (24) polyoxypropylene (24) glyceryl ether, and PEG-400, and any combination of two or more of these is used. There are no particular limitations on these polyhydric alcohols, so long as they are normally contained in cosmetic compositions, and commercially available products can be used.

[0014] In the composition of the present invention, the total content of component (B) is not particularly limited, and may be, for example, 0.01 mass% or more, 0.05 mass% or more, or 0.1 mass% or more, and 20 mass% or less, 15 mass% or less, or 10 mass% or less, or a compatible combination thereof, based on the entire composition. Also, the content of component (B) may be 0.01 to 20 mass%, 0.05 to 15 mass%, or 0.1 to 10 mass% based on the entire composition. By using the component (A) in this range, the cosmetic composition will feel less sticky after application, and will also be more likely to provide a more excellent feel when used, such as no squeaky or dry feeling, and will also be more likely to provide formulation stability.

[0015] In the composition of the present invention, the mass ratio of the contents of component (A) and component (B) is not particularly limited, but from the viewpoints of usability, formulation stability, and the like, it is, for example, preferably 1:75 to 20:1, and more preferably 1:50 to 10:1.

[0016] The formulation of the composition of the present invention is not particularly limited, and may be an emulsion type, an aqueous formulation type, an oil-based formulation type, an oil gel formulation type, etc. In the case of an emulsion type, it may be a water-in-oil type or an oil-in-water type, and may be a W / O type, an O / W / O type, a (W1+W2) / O type, an O / W type, a W / O / W type, an (O1+O2) / W type, etc.

[0017] When the composition of the present invention is in the form of an emulsion, it usually contains an aqueous phase component and an oil phase component. The aqueous phase component may be any component that dissolves in water at 25 to 90° C. The oil phase component is not limited to oils and generally includes powders, etc., and may be any component that undergoes phase separation from water after being suspended in water at 25 to 90° C. and left to stand for 1 hour. When the composition of the present invention is in the form of an emulsion, the mass ratio of the contents of the aqueous phase component and the oil phase component is not particularly limited, but is preferably 30:70 to 90:10, more preferably 60:40 to 85:15.

[0018] The composition of the present invention is suitable for use as a skin external preparation because it has an excellent feel when applied to the skin. The skin external preparation can be used, for example, as a cosmetic preparation including medicines and quasi-drugs. Particularly preferred is a cosmetic preparation. Specific examples of the cosmetic preparation include skin care cosmetics such as lotion, milky lotion, and cream, makeup cosmetics such as makeup base and foundation, and sunscreen cosmetics such as sunscreen lotion and sunscreen cream. In addition, the cosmetic preparation can be in various forms such as liquid, milky lotion, and cream.

[0019] Furthermore, the composition of the present invention may contain optional components other than the above-mentioned components, so long as the effects of the composition are not impaired. The optional components are not particularly limited and may be any known components used in the field of compositions such as cosmetics. The optional components may be used in the present invention alone or in combination of two or more.

[0020] Examples of such optional components include oils, powders, alcohols, ethers, moisturizers, surfactants, sequestering agents, pearlescent agents, amino acids, organic amines, polymer emulsions, pH adjusters, vitamins, antioxidants, preservatives, water-soluble polymers, fragrances, and various active ingredients.

[0021] Examples of oils include silicone oils, polar oils, natural oils, and hydrocarbons.

[0022] Silicone oils include dimethylpolysiloxane (dimethicone), cyclopentasiloxane, decamethylcyclopentasiloxane, caprylyl methicone, trimethylsiloxysilicate, and the like.

[0023] Polar oils include synthetic ester oils such as isopropyl myristate, cetyl octanoate, octyldodecyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, decyl oleate, hexyldecyl dimethyloctanoate, cetyl lactate, myristyl lactate, lanolin acetate, isocetyl stearate, isocetyl isostearate, cholesteryl 12-hydroxystearate, ethylene glycol di-2-ethylhexylate, dipentaerythritol fatty acid esters, monoisopropyl ether, ethylhexyl ... N-Alkyl glycol isostearate, neopentyl glycol dicaprate, diisostearyl malate, glyceryl di-2-heptylundecanoate, trimethylolpropane tri-2-ethylhexylate, trimethylolpropane triisostearate, pentaneerythritol tetra-2-ethylhexylate, glyceryl tri-2-ethylhexanoate, trimethylolpropane triisostearate, cetyl 2-ethylhexanoate, 2-ethylhexyl palmitate, glyceryl trimyristate, tri-2-heptyl undecanoate Examples of suitable glycerides include undecanoic acid glyceride, castor oil fatty acid methyl ester, oleic acid oil, cetostearyl alcohol, acetoglyceride, 2-heptylundecyl palmitate, diisobutyl adipate, N-lauroyl-L-glutamic acid-2-octyldodecyl ester, di-2-heptylundecyl adipate, ethyl laurate, di-2-ethylhexyl sebacate, 2-hexyldecyl myristate, 2-hexyldecyl palmitate, 2-hexyldecyl adipate, diisopropyl sebacate, 2-ethylhexyl succinate, isononyl isononanoate, ethyl acetate, butyl acetate, amyl acetate, and triethyl citrate.

[0024] Examples of natural oils include avocado oil, camellia oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, persic oil, wheat germ oil, sasanqua oil, castor oil, linseed oil, safflower oil, cottonseed oil, perilla oil, soybean oil, peanut oil, tea seed oil, kaya oil, rice bran oil, Chinese giri oil, Japanese tung oil, jojoba oil, germ oil, sunflower oil, triglycerin, glyceryl trioctanoate, and glyceryl triisopalmitate.

[0025] Examples of the hydrocarbon oil include isododecane, isohexadecane, squalane, hydrogenated poly(C6-12) olefin, and hydrogenated polyisobutene.

[0026] The powder may be spherical, needle-like, plate-like, or the like, and its shape is not particularly limited. Examples of the powder include inorganic white pigments (e.g., titanium dioxide, zinc oxide, etc.); inorganic red pigments (e.g., iron oxide (red oxide), iron titanate, etc.); inorganic brown pigments (e.g., γ-iron oxide, etc.); inorganic yellow pigments (e.g., yellow iron oxide, ocher, etc.); inorganic black pigments (e.g., black iron oxide, low-order titanium oxide, etc.); inorganic purple pigments (e.g., mango violet, cobalt violet, etc.); inorganic green pigments (e.g., chromium oxide, chromium hydroxide, cobalt titanate, etc.); inorganic blue pigments (e.g., ultramarine, Prussian blue, etc.); pearl pigments (e.g., titanium oxide coated mica, titanium oxide coated bismuth oxychloride, titanium oxide coated talc, colored titanium oxide coated mica, bismuth oxychloride, fish scale foil, etc.); metal powder pigments (e.g., aluminum powder, copper powder, etc.); organic pigments such as zirconium, barium, or aluminum lake (e.g., For example, organic pigments such as Red No. 201, Red No. 202, Red No. 204, Red No. 205, Red No. 220, Red No. 226, Red No. 228, Red No. 405, Orange No. 203, Orange No. 204, Yellow No. 205, Yellow No. 401, and Blue No. 404; Red No. 3, Red No. 104, Red No. 106, Red No. 227, Red No. 230, Red No. 401, Red No. 505, Orange No. 205, Yellow No. 4, Yellow No. 5, Yellow 202, Yellow No. 203, Green No. 3, and Blue No. 1; natural pigments ( For example, chlorophyll, β-carotene, etc.; inorganic powders (for example, talc, kaolin, mica, sericite, muscovite, phlogopite, synthetic mica, red mica, biotite, vermiculite, magnesium carbonate, calcium carbonate, aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, tungstate metal salts, magnesium, silica, alumina, zeolite, barium sulfate, calcined calcium sulfate (calcined gypsum), etc. C), calcium phosphate, fluorapatite, hydroxyapatite, ceramic powder , boron nitride, etc.); organic powders (e.g., polyamide resin powder (nylon powder), polyethylene powder, poly(methyl (meth)acrylate powder, polystyrene powder, styrene and acrylic acid copolymer resin powder, silicone resin powder, benzoguanamine resin powder, polytetrafluoroethylene powder, cellulose powder, silicone composite spherical powder (e.g., (vinyl dimethicone / methicone silsesquioxane) crosspolymer, (diphenyl dimethicone / vinyl diphenyl dimethicone / silsesquioxane) crosspolymer, polysilicone-22, polysilicone-1 crosspolymer, etc.); metal soaps (e.g., zinc myristate, palmitate, etc.); calcium stearate, aluminum stearate); organically modified clay minerals (e.g., organically modified Bentonite, organically modified hectorite, etc.

[0027] Examples of alcohols include those other than component (B), such as monohydric alcohols such as ethanol, isopropanol, cetanol, batyl alcohol, behenyl alcohol, palmitoleyl alcohol, heptadecanol, 1-heptadecanol, stearyl alcohol, isostearyl alcohol, elaidyl alcohol, oleyl alcohol, linoleyl alcohol, elaidolinoleyl alcohol, linolenyl alcohol, elaidolinolenyl alcohol, ricinoleyl alcohol, nonadecyl alcohol, arachidyl alcohol, heneicosanol, and erucyl alcohol; ethylene glycol, 1,3-butylene glycol, trimethylene glycol, and the like. dihydric alcohols such as 1,2-butylene glycol, propylene glycol, dipropylene glycol, propanediol, 1,2-pentanediol, 3-methyl-1,3-butanediol, tetramethylene glycol, 2,3-butylene glycol, pentamethylene glycol, 2-butene-1,4-diol, hexylene glycol, and octylene glycol; trihydric alcohols such as trimethylolpropane; tetrahydric alcohols such as pentaerythritol; pentahydric alcohols such as xylitol; polyhydric alcohol polymers such as triglycerin, tetraglycerin, and polyglycerin; sugar alcohols such as starch decomposition sugar reduction alcohols; polyglycerin; Alcohol alkyl ethers such as ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, ethylene glycol monophenyl ether, ethylene glycol monohexyl ether, ethylene glycol mono 2-methylhexyl ether, ethylene glycol isoamyl ether, ethylene glycol benzyl ether, and ethylene glycol isopropyl ether; alcohol alkyl ethers such as diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monobutyl ether, triethylene glycol monomethyl ether, triethylene glycol monoethyl ether, propylene glycol monomethyl ether, propylene glycol monoethyl ether, propylene glycol monobutyl ether, propylene glycol isopropyl ether, dipropylene glycol methyl ether, dipropylene glycol ethyl ether, and dipropylene glycol butyl ether; glycerin monoalkyl ethers such as xyl alcohol, selachyl alcohol, and batyl alcohol; Alcohol polymers such as diethylene glycol, triethylene glycol, polypropylene glycol, tetraethylene glycol, and polyethylene glycol; Glysolid; tetrahydrofurfuryl alcohol; POE-tetrahydrofurfuryl alcohol; POP-butyl ether; POP·POE-butyl ether; tripolyoxypropylene glycerin ether; POP-glycerin ether; POP-glycerin ether phosphate; POP·POE-pentaneerythritol ether, etc.

[0028] Examples of the ether include, in addition to those corresponding to the above-mentioned alcohols, ethylene glycol dimethyl ether, ethylene glycol diethyl ether, ethylene glycol dibutyl ether, diethylene glycol dimethyl ether, diethylene glycol diethyl ether, diethylene glycol methyl ethyl ether, ethylene glycol monomethyl ether acetate, ethylene glycol monoethyl ether acetate, ethylene glycol monobutyl ether acetate, ethylene glycol monophenyl ether acetate, ethylene glycol diadipate, ethylene glycol disuccinate, diethylene glycol monoethyl ether acetate, diethylene glycol monobutyl ether acetate, propylene glycol monomethyl ether acetate, propylene glycol monoethyl ether acetate, propylene glycol monopropyl ether acetate, and propylene glycol monophenyl ether acetate.

[0029] Examples of moisturizing agents include chondroitin sulfate and its salts, hyaluronic acid and its salts, muco These include lecithin sulfate, caronic acid, atelocollagen, cholesteryl-12-hydroxystearate, sodium lactate, dl-pyrrolidone carboxylate, short-chain soluble collagen, diglycerin (EO)PO adduct, Rosa rugosa extract, Achillea millefolium extract, and Melilot extract.

[0030] The surfactants include anionic surfactants, cationic surfactants, amphoteric surfactants, and nonionic surfactants.

[0031] Examples of anionic surfactants include fatty acid soaps (e.g., sodium laurate, sodium palmitate, etc.); higher alkyl sulfates (e.g., sodium lauryl sulfate, potassium lauryl sulfate, etc.); alkyl ether sulfates (e.g., POE triethanolamine lauryl sulfate, sodium POE lauryl sulfate, etc.); N-acyl sarcosinates (e.g., sodium lauroyl sarcosinate, etc.); higher fatty acid amide sulfonates (e.g., sodium N-myristoyl-N-methyl taurine, sodium coconut oil fatty acid methyl tauride, sodium lauryl methyl tauride, etc.); phosphates (sodium POE oleyl ether phosphate, sodium POE stearyl ether phosphate, etc.); sulfosuccinates (e.g., sodium di-2-ethylhexyl sulfosuccinate, sodium monolauroyl monoethanolamide polyoxyethylene sulfosuccinate, sodium lauryl polypropylene glycol ... sodium citrate, etc.); alkylbenzene sulfonates (e.g., sodium linear dodecylbenzene sulfonate, triethanolamine linear dodecylbenzene sulfonate, linear dodecylbenzene sulfonic acid, etc.); higher fatty acid ester sulfate salts (e.g., sodium hydrogenated coconut oil fatty acid glycerin sulfate, etc.); N-acyl glutamates (e.g., monosodium N-lauroyl glutamate, disodium N-stearoyl glutamate, monosodium N-myristoyl-L-glutamate, etc.); sulfated oils (e.g., turmeric oil, etc.); POE alkyl ether carboxylic acids; POE alkyl allyl ether carboxylates; α-olefin sulfonates; higher fatty acid ester sulfonates; secondary alcohol sulfate salts; higher fatty acid alkylolamide sulfate salts; sodium lauroyl monoethanolamide succinate; ditriethanolamine N-palmitoyl aspartate; sodium caseinate, etc.

[0032] Examples of the cationic surfactant include alkyl trimethyl ammonium salts (e.g., stearyl trimethyl ammonium chloride, lauryl trimethyl ammonium chloride, etc.); alkyl pyridinium salts (e.g., cetyl pyridinium chloride, etc.); distearyl dimethyl ammonium chloride, dialkyl dimethyl ammonium salts; poly(N,N'-dimethyl- 3,5-Methylenepiperidinium;Alkyl quaternary ammonium salts;Alkyl dimethyl benzyl Examples of the alkylaminoethyl ammonium salt include benzyl ammonium salts; alkyl isoquinolinium salts; dialkyl morphonium salts; POE alkyl amines; alkyl amine salts; polyamine fatty acid derivatives; amyl alcohol fatty acid derivatives; benzalkonium chloride; and benzethonium chloride.

[0033] Examples of amphoteric surfactants include imidazoline-based amphoteric surfactants (e.g., 2-undecyl-N,N,N-(hydroxyethylcarboxymethyl)-2-imidazoline sodium, 2-cocoyl-2-imidazolinium hydroxide-1-carboxyethyloxy disodium salt, etc.); betaine-based surfactants (e.g., 2-heptadecyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, lauryl dimethylaminoacetic acid betaine, alkyl betaine, amido betaine, sulfobetaine, etc.).

[0034] Nonionic surfactants include sucrose fatty acid esters, alkyl glycosides, polyether-modified silicones (e.g., polyethylene glycol-10 dimethicone, polyethylene glycol-12 dimethicone, PEG-9 polymethylsiloxyethyl dimethicone, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, PEG-9 polydimethyl Siloxyethyl dimethicone, etc.; polyglycerin modified silicones (e.g., polyglyceryl-3 disiloxane dimethicone, polyglyceryl-3 polydimethylsiloxyethyl dimethicone, etc.); sorbitan fatty acid esters (e.g., sorbitan monooleate, sorbitan monostearate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, diglycerol sorbitan penta-2-ethylhexyl acid, tetra-2-ethyl diglycerol sorbitan dihexylate, etc.); glycerin fatty acids (for example, glycerin monocottonseed oil fatty acid, glycerin monoerucate, glycerin sesquioleate, glycerin monostearate, glycerin α,α'-oleic acid pyroglutamate, glycerin monostearate malate, etc.); propylene glycol fatty acid esters (for example, propylene glycol monostearate, etc.); POE castor oil / hydrogenated castor oil derivatives (POE castor oil, POE hydrogenated castor oil, etc.); and non-hydrophilic nonionic surfactants such as glycerin alkyl ethers.Also, polyglycerol fatty acid esters (e.g., polyglyceryl monooleate, polyglyceryl monostearate, etc.); POE sorbitan fatty acid esters (e.g., POE sorbitan monooleate, POE sorbitan monostearate, POE sorbitan tetraoleate, etc.); POE sorbit fatty acid esters (e.g., POE sorbitan monolaurate, POE sorbit monooleate, POE sorbit pentaoleate, POE sorbit monostearate, etc.); POE glycerin fatty acid esters (e.g., POE monooleates such as POE glycerin monostearate, POE glycerin monoisostearate, POE glycerin triisostearate, etc.); POE fatty acid esters (e.g., POE distearate, POE monodioleate, ethylene glycol distearate, etc.); POE alkyl ethers (e.g., POE lauryl ether, POE oleyl ether, POE stearyl ether, POE-behenyl ether, POE-2-octyldodecyl ether, POE cholestanol ether, etc.); POE alkyl phenyl ethers (e.g., POE nonylphenyl ether, etc.); Pluronic types (e.g., Pluronic (registered trademark), etc.); POE·POP alkyl ethers (e.g., POE·POP cetyl ether, POE·POP-2-decyltetradecyl ether, POE·POP monobutyl ether, POE·POP hydrogenated lanolin, POE·POP glycerin ether, etc.); tetra POE·tetra POP ether. Hydrophilic nonionic surfactants such as ethylenediamine condensates (e.g., Tetronic, etc.); POE castor oil hydrogenated castor oil derivatives (e.g., POE castor oil, POE hydrogenated castor oil, POE hydrogenated castor oil monoisostearate, POE hydrogenated castor oil triisostearate, POE hydrogenated castor oil monopyroglutamic acid monoisostearate diester, POE hydrogenated castor oil maleic acid, etc.); POE beeswax / lanolin derivatives (e.g., POE sorbitol beeswax, etc.); alkanolamides (e.g., coconut oil fatty acid diethanolamide, lauric acid monoethanolamide, fatty acid isopropanolamide, etc.); POE propylene glycol fatty acid esters; POE alkylamines; POE fatty acid amides; alkyl glucosides; alkyl ethoxydimethylamine oxides; and trioleyl phosphate.

[0035] Examples of sequestering agents include 1-hydroxyethane-1,1-diphosphonic acid, 1-hydroxyethane-1,1-diphosphonic acid tetrasodium salt, disodium edetate, trisodium edetate, tetrasodium edetate, sodium citrate, sodium polyphosphate, sodium metaphosphate, gluconic acid, phosphoric acid, citric acid, ascorbic acid, succinic acid, edetic acid, and trisodium ethylenediaminehydroxyethyltriacetate.

[0036] Examples of pearlescent agents include glycol distearate and titanium mica.

[0037] Amino acids include, for example, neutral amino acids (e.g., threonine, cysteine, etc.); Examples of amino acid derivatives include sodium acyl sarcosine (sodium lauroyl sarcosine), Examples of such antibacterial agents include sodium glutamate, sodium acyl β-alanine, glutathione, and pyrrolidone carboxylic acid.

[0038] Examples of the organic amine include monoethanolamine, diethanolamine, triethanolamine, morpholine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, and 2-amino-2-methyl-1-propanol.

[0039] Examples of polymer emulsions include acrylic resin emulsions, polyethyl acrylate emulsions, acrylic resin liquids, polyacrylic alkyl ester emulsions, polyvinyl acetate resin emulsions, and natural rubber latex.

[0040] Examples of pH adjusters include buffers such as lactic acid-sodium lactate, citric acid-sodium citrate, and succinic acid-sodium succinate, and are usually used to adjust the pH of the internal phase (aqueous component).

[0041] Examples of vitamins include vitamins A, B1, B2, B6, C, E and their derivatives, pantothenic acid and its derivatives, biotin, etc.

[0042] Examples of antioxidants include tocopherols, dibutylhydroxytoluene (BHT), butylhydroxyanisole, pyrosulfite, gallic acid esters, phosphoric acid, citric acid, ascorbic acid, maleic acid, malonic acid, succinic acid, fumaric acid, cephalin, hexametaphosphate, phytic acid, and ethylenediaminetetraacetate.

[0043] Examples of preservatives include parabens and phenoxyethanol.

[0044] Examples of water-soluble polymers include plant-based polymers (e.g., gum arabic, tragacanth gum, galactan, guar gum, carob gum, karaya gum, carrageenan, pectin, agar, quince seed, algae colloid (cassou extract), starch (coco), etc. (corn, potato, wheat), glycyrrhizic acid); microbial polymers (e.g. natural water-soluble polymers such as xanthan gum, dextran, succinoglucan, pullulan, etc.; animal polymers (e.g., collagen, casein, albumin, gelatin, etc.); semi-synthetic water-soluble polymers such as starch-based polymers (e.g., carboxymethyl starch, methylhydroxypropyl starch, etc.); cellulose-based polymers (hydroxypropylmethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, methylcellulose, ethylcellulose, hydroxypropylmethylcellulose stearoxy ether, sodium cellulose sulfate, carboxymethylcellulose, sodium carboxymethylcellulose, crystalline cellulose, cellulose powder, etc.); alginic acid-based polymers (e.g., sodium alginate, propylene glycol alginate, etc.), etc. Examples of the water-soluble synthetic polymer include polyoxyethylene polymers (for example, polyethylene glycol 20,000, 40,000, 60,000, etc.); polyethyleneimine; and cationic polymers.

[0045] Examples of the various active ingredients include anti-inflammatory agents (e.g., salicylic acid derivatives, hinokitiol, zinc oxide, allantoin, etc.); whitening agents (e.g., placenta extract, saxifrage extract, arbutin, resorcinol derivatives, etc.); various extracts (e.g., Phellodendron bark, Coptis japonica, Lithospermum root, Peony root, Swertia japonica, Birch, Sage, Loquat, Carrot, Aloe, Mallow, Iris, Grape, Coix seed, Loofah, Lily, Saffron, Cnidium rhizome, Angelica acutiloba, Hypericum perforatum, Ononis, Garlic, Capsicum annuum, Citrus chinensis, Angelica acutiloba, Seaweed, etc.), activators (e.g., Examples of such agents include royal jelly, photosensitizers, cholesterol derivatives, etc.; blood circulation promoters (e.g., nonylic acid valenylamide, nicotinic acid benzyl ester, nicotinic acid β-butoxyethyl ester, capsaicin, zingerone, cantharides tincture, ichthammol, tannic acid, α-borneol, tocopherol nicotinate, inositol hexanicotinate, cyclandelate, cinnarizine, tolazoline, acetylcholine, verapamil, cepharanthine, γ-oryzanol, etc.); antiseborrheic agents (e.g., sulfur, thianthol, etc.); and anti-inflammatory agents (e.g., tranexamic acid, thiotaurine, hypotaurine, etc.).

[0046] The composition of the present invention can be manufactured according to a conventional method in accordance with the dosage form. EXAMPLES

[0047] The present invention will be described in detail below with reference to examples. However, these are merely illustrative of the present invention and the scope of the present invention is not limited to these examples.

[0048] An oil-in-water emulsion type composition was prepared according to the formulation shown in Table 1 by a conventional method. According to the formulation shown in Table 2, an aqueous formulation was prepared by a conventional method. A water-in-oil emulsion type composition was prepared according to the formulation shown in Table 3 by a conventional method.

[0049] The obtained compositions were evaluated for the following items, and the results are shown in Table 1.

[0050] (Crystallization) Each composition was placed in a glass standard bottle and left to stand in a thermostatic chamber set at 0° C. for one month, after which a specialist evaluator visually evaluated the composition on the following four-point scale. ◎: No crystal precipitation is observed ○: Very little crystallization is observed △: A small amount of crystals was observed. ×: Crystal precipitation is observed

[0051] (Sticky feeling) An appropriate amount of the cosmetic product was applied to the skin, and a specialist evaluator scored the stickiness of the skin one minute after application according to the following criteria. 5 points: No sticky feeling 4 points: Almost no stickiness 3 points: Feels slightly sticky 2 points: Sticky feeling 1 point: Very sticky The average scores of the 10 evaluators were assigned to the following ratings. ◎: More than 4 points: Very good ○: More than 3 points and 4 points or less: Good △: More than 2 points, 3 points or less: slightly poor × : 2 points or less : Defective

[0052] (creaking sensation) An appropriate amount of the cosmetic was applied to the skin, and the feeling of squeaking on the skin during application was scored by a specialist evaluator according to the following criteria. 5 points: No creaking sensation 4 points: Almost no creaking sensation 3 points: Slight creaking sensation 2 points: Creaking sensation 1 point: Very squeaky The average scores of the 10 evaluators were assigned to the following ratings. ◎: More than 4 points: Very good ○: More than 3 points and 4 points or less: Good △: More than 2 points, 3 points or less: slightly poor × : 2 points or less : Defective

[0053] (Moisturizing / freshness) An appropriate amount of the cosmetic product was applied to the skin, and expert evaluators scored the skin's moisturizing / moisturizing feeling one minute after application according to the following criteria. 5 points: Very moist / feels fresh 4 points: Moist / feels fresh 3 points: Slightly moist / feels fresh 2 points: Almost no moist feeling 1 point: Not moist / refreshing The average scores of the 10 evaluators were assigned to the following ratings. ◎: More than 4 points: Very good ○: More than 3 points and 4 points or less: Good △: More than 2 points, 3 points or less: slightly poor × : 2 points or less : Defective

[0054] [Table 1-1]

[0055] [Table 1-2]

[0056] [Table 2-1]

[0057] [Table 2-2]

[0058] [Table 3-1]

[0059] [Table 3-2]

[0060] The compositions of the examples containing components (A) and (B) are less likely to become sticky. Furthermore, it was found that the product had an excellent feel when used, such as a lack of squeaking sensation and a moist / fresh feeling, and also had excellent formulation stability, with crystal precipitation being suppressed. [Industrial Applicability]

[0061] The composition of the present invention can be preferably applied to external preparations for the skin, such as cosmetics, cosmetics including quasi-drugs, and medicines.

Claims

1. A composition comprising (A) dipotassium glycyrrhizinate and (B) a polyhydric alcohol, The content of (A) is 0.2 to 1.0 mass% based on the total mass of the composition, The composition, wherein (B) is one or more selected from 1,3-propanediol, cyclohexylglycerin, isopentyldiol, polyoxyethylene (24) polyoxypropylene (24) glyceryl ether, and PEG-400.

2. The composition according to claim 1, wherein the content of (B) is 0.01 to 20 mass% based on the total mass of the composition.

3. The composition according to claim 1, wherein the mass ratio of the contents of component (A) and component (B) is 1:75 to 20:

1.

4. The composition according to any one of claims 1 to 3, which is an external preparation for skin.

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