Use method of mastitis prevention sheet, mastitis prevention sheet and manufacturing method of mastitis prevention sheet

Abstract

To provide a use method of a mastitis prevention sheet capable of preventing an adhesive layer from easily peeling off from a teat, mastitis prevention sheet and manufacturing method of the mastitis prevention sheet.SOLUTION: A mastitis prevention sheet 10 for livestock includes a base material layer 11, and an adhesive layer 12 containing chitosan and supported by the base material layer 11. A surface of the adhesive layer 12, opposite to a surface facing the base material layer 11 is an adhesive surface 12S. A use method of the mastitis prevention sheet 10 includes: bringing a first part of the adhesive surface 12S into close contact with a second part of the adhesive surface to paste the mastitis prevention sheet 10 to a teat such that the mastitis prevention sheet 10 has a cylindrical shape surrounding the teat; and bringing the first part of the adhesive surface 12S into close contact with the second part of the adhesive surface 12S at a position away from a teat orifice of the teat so as to close the cylinder end of the mastitis prevention sheet 10.SELECTED DRAWING: Figure 1

Description

[Technical field]

[0001] The present disclosure relates to a method for using a mastitis prevention sheet, a mastitis prevention sheet, and a method for manufacturing a mastitis prevention sheet. [Background technology]

[0002] One example of a teat orifice protection patch for livestock includes a laminate of an elastic sheet and an adhesive layer laminated on a first surface of the elastic sheet. The laminate has a tensile stress at two times elongation within the range of 0.1 N to 5 N. The teat orifice protection patch further includes a protective film laminated on a second surface, which is the surface opposite to the first surface of the elastic sheet, and a release sheet attached to the adhesive layer. When the teat orifice protection patch is used, first, the release sheet is peeled off from the adhesive layer. Next, the adhesive layer is attached to the teat so as to cover the teat orifice located at the tip of the teat. Then, the protective sheet is removed from the elastic sheet (see, for example, Patent Document 1). [Prior art documents] [Patent documents]

[0003] [Patent Document 1] International Publication No. 2017 / 150203 Summary of the Invention [Problem to be solved by the invention]

[0004] Incidentally, milk synthesized in the mammary gland is secreted from the nipple orifice. Therefore, when a nipple orifice protection patch is attached to the nipple so as to cover the nipple orifice, milk secreted from the nipple orifice gets between the nipple and the nipple orifice protection patch. This reduces the adhesiveness of the adhesive layer to the nipple, making the nipple orifice protection patch more likely to peel off from the nipple. [Means for solving the problem]

[0005] A method of using a mastitis prevention sheet for solving the above problem is a method of using a mastitis prevention sheet for livestock having an antibacterial effect, comprising a base layer and an adhesive layer containing chitosan and supported by the base layer. In the adhesive layer, the surface opposite to the surface facing the base layer is an adhesive surface. A method of using the mastitis prevention sheet includes attaching the mastitis prevention sheet to the nipple so that the mastitis prevention sheet has a tubular shape surrounding the nipple, and closely adhering a first portion of the adhesive surface to a second portion of the adhesive surface at a position away from the nipple orifice of the nipple so as to close the tubular end of the mastitis prevention sheet.

[0006] According to the method of using the mastitis prevention sheet, the mastitis prevention sheet is attached to the nipple so as to have a tubular shape surrounding the nipple. This makes it difficult for milk secreted from the nipple opening to spread between the adhesive surface and the nipple. Also, since the first part of the adhesive surface adheres to the second part at a position away from the nipple opening, milk secreted from the nipple opening is unlikely to remain between the adhesive surface and the nipple opening. Therefore, the adhesive layer is unlikely to peel off from the nipple, and as a result, the mastitis prevention sheet is unlikely to peel off from the nipple.

[0007] In the above-mentioned method of using the mastitis prevention sheet, attaching the mastitis prevention sheet to the nipple may include adhering the third part of the adhesive surface to the fourth part of the adhesive surface, so that the mastitis prevention sheet has a tubular shape surrounding the nipple.

[0008] According to the method of using the mastitis prevention sheet described above, the adhesive portion formed by adhering the fourth portion to the third portion of the adhesive surface is less susceptible to milk secreted from the nipple opening, making it difficult for the adhesive layer to peel off from the nipple.

[0009] In the method of using the above-mentioned mastitis prevention sheet, the surface of the base layer opposite the surface facing the adhesive layer is an adhesive surface, and attaching the mastitis prevention sheet to the nipple may include adhering a third part of the adhesive surface to a first part of the adhesive surface of the base layer, thereby attaching the mastitis prevention sheet to the nipple so that the mastitis prevention sheet has a tubular shape surrounding the nipple.

[0010] According to the method of using the mastitis prevention sheet, the adhesive portion formed by adhering the third part of the adhesive surface to the first part of the non-adhesive surface is less susceptible to milk secreted from the nipple orifice, making it difficult for the adhesive layer to peel off from the nipple.

[0011] In the above-mentioned method of using the mastitis prevention sheet, the mastitis prevention sheet may have a through hole penetrating the mastitis prevention sheet in the thickness direction of the mastitis prevention sheet, and attaching the mastitis prevention sheet may include attaching the mastitis prevention sheet to the nipple so that the through hole is positioned at the tubular end of the mastitis prevention sheet.

[0012] According to the above-mentioned method of using the mastitis prevention sheet, a through hole is located at the tubular end of the mastitis prevention sheet, so that milk secreted from the nipple can be discharged from the through hole at the tubular end outside the space surrounded by the mastitis prevention sheet.

[0013] The method of using the above-mentioned mastitis prevention sheet may further include discharging milk from the through hole located at the tubular end of the mastitis prevention sheet.

[0014] According to the above-mentioned method of using the mastitis prevention sheet, the mastitis prevention sheet is even less likely to peel off from the nipple compared to when milk secreted from the nipple opening remains within the space surrounded by the mastitis prevention sheet.

[0015] The mastitis prevention sheet for solving the above problems is an antibacterial mastitis prevention sheet comprising a base layer and an adhesive layer containing 2% by mass or more of chitosan and supported by the base layer, wherein the adhesive layer has an adhesive surface on the side opposite to the surface facing the base layer, and the adhesion strength between a first portion of the adhesive surface and a second portion of the adhesive surface is 2 N / 25 mm or more and 10 N / 25 mm or less.

[0016] A method for producing a mastitis prevention sheet for solving the above problems is a method for producing a mastitis prevention sheet for livestock having an antibacterial effect, comprising a base layer and an adhesive layer containing chitosan and supported by the base layer. The method includes forming the base layer, forming the adhesive layer containing 2% by mass or more of the chitosan, and having an adhesion strength of 2 N / 25 mm or more and 10 N / 25 mm or less between a first portion of the adhesive surface, which is the surface opposite to the surface facing the base layer, and a second portion of the adhesive surface, and bonding the adhesive layer to the base layer. Forming the adhesive layer includes using an acidic aqueous solution containing the chitosan.

[0017] According to the above mastitis prevention sheet, the adhesive layer contains 2% by mass or more of chitosan, so that the mastitis prevention sheet can have an antibacterial effect. In addition, since the adhesion strength when the first part of the adhesive surface is adhered to the second part is 2N / 25mm or more, the mastitis prevention sheet can be attached to the nipple by the adhesion part formed by adhesion between the first part and the second part. In addition, since the adhesion strength between the first part and the second part of the adhesive surface is 10N / 25mm or less, when the tubular end of the mastitis prevention sheet is blocked below the nipple orifice, it is possible to form a space capable of storing milk secreted from the nipple orifice.

[0018] In the above-mentioned mastitis prevention sheet, when viewed from a viewpoint opposite to the plane in which the mastitis prevention sheet spreads, the mastitis prevention sheet may comprise a band-shaped portion along the outer edge of the mastitis prevention sheet, and a through hole that penetrates the mastitis prevention sheet along the thickness direction of the mastitis prevention sheet and is located in the band-shaped portion, the through hole having a shape extending along the outer edge of the mastitis prevention sheet.

[0019] According to the above-mentioned mastitis prevention sheet, when the mastitis prevention sheet is attached to the nipple, it is possible to position a through hole below the nipple orifice, so that milk secreted from the nipple orifice can be discharged through the through hole from the space surrounded by the mastitis prevention sheet.

[0020] In the above mastitis prevention sheet, the length of the through holes may be 1 mm or more and 4 mm or less when viewed from a viewpoint opposite to the plane along which the mastitis prevention sheet spreads.

[0021] According to the above-mentioned mastitis prevention sheet, when the length of the through holes is 1 mm or more and 4 mm or less, it is possible to increase the reliability of the mastitis prevention sheet adhering to the nipple and also to increase the reliability of milk being discharged through the through holes.

[0022] In the above mastitis prevention sheet, the adhesive layer may be in contact with the base layer, and at least a part of the sheet body composed of the adhesive layer and the base layer may have a total light transmittance of 30% or more.

[0023] According to the above-mentioned mastitis prevention sheet, when the sheet body is attached to the nipple, it is possible to visually observe the condition of the nipple or the space formed below the nipple through the part of the sheet body having a total light transmittance of 30% or more. Effect of the Invention

[0024] According to the present disclosure, the mastitis prevention sheet having antibacterial properties is less likely to peel off from the nipple. [Brief description of the drawings]

[0025] [Figure 1] FIG. 1 is a cross-sectional view showing the structure of a mastitis prevention sheet. [Diagram 2] FIG. 2 is a plan view showing the structure of the mastitis prevention sheet. [Diagram 3] FIG. 3 is a plan view showing the structure of a first modified example of the mastitis prevention sheet. [Figure 4] FIG. 4 is a plan view showing the structure of a second modified example of the mastitis prevention sheet. [Diagram 5] FIG. 5 is a plan view showing the structure of a third modified example of the mastitis prevention sheet. [Figure 6] FIG. 6 is a process diagram showing one step included in a method of using a mastitis prevention sheet. [Figure 7] FIG. 7 is a process diagram showing one step included in a method of using a mastitis prevention sheet. [Figure 8] FIG. 8 is a process diagram showing one step included in a method of using a mastitis prevention sheet. [Figure 9] FIG. 9 is a process diagram showing one step included in a method of using a mastitis prevention sheet. [Figure 10] FIG. 10 is a process diagram showing one step included in a method of using a mastitis prevention sheet. [Figure 11] FIG. 11 is a flow chart for explaining the step of forming a base material layer, which is included in the method for producing a mastitis prevention sheet. [Figure 12] FIG. 12 is a flow chart for illustrating the adhesive layer forming step included in the method for producing a mastitis prevention sheet. [Figure 13] FIG. 13 is a flow chart showing the steps of forming a mastitis prevention sheet, which are included in the method of producing a mastitis prevention sheet. [Figure 14] FIG. 14 is a table showing the evaluation results of Test Example 1. [Figure 15] FIG. 15 is a table showing the evaluation results of Test Example 2. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0026] An embodiment of a method for using a mastitis prevention sheet, a mastitis prevention sheet, and a method for manufacturing a mastitis prevention sheet will be described with reference to Figures 1 to 15 . [Mastitis prevention sheet] The mastitis prevention sheet will be described with reference to Figures 1 to 5. Figure 1 shows the cross-sectional structure of the mastitis prevention sheet along a plane perpendicular to the plane in which the mastitis prevention sheet spreads.

[0027] As shown in FIG. 1, the mastitis prevention sheet 10 includes a base layer 11 and an adhesive layer 12 supported by the base layer 11. The mastitis prevention sheet 10 has an antibacterial effect. In the example shown in FIG. 1, the adhesive layer 12 is in contact with the base layer 11. For example, a printed layer may be located between the adhesive layer 12 and the base layer 11. In the adhesive layer 12, the surface opposite to the surface facing the base layer 11 is the adhesive surface 12S. In the example shown in FIG. 1, since the adhesive layer 12 is in contact with the base layer 11, the surface opposite to the surface of the adhesive layer 12 in contact with the base layer 11 is the adhesive surface 12S. The adhesive surface 12S is the surface that is attached to the teat of the livestock to which the mastitis prevention sheet 10 is to be attached. The livestock may be, for example, a dairy cow.

[0028] The mastitis prevention sheet 10 of the present disclosure satisfies the following conditions. (Condition 1) Contains 2% by mass or more of chitosan. (Condition 2) The adhesive strength between the first portion of the adhesive surface 12S and the second portion of the adhesive surface 12S is 2 N / 25 mm or more and 10 N / 25 mm or less.

[0029] Since the adhesive layer 12 contains 2% by mass or more of chitosan, the mastitis prevention sheet 10 can have an antibacterial effect. Furthermore, since the adhesion strength when the first part of the adhesive surface 12S is adhered to the second part is 2N / 25mm or more, the mastitis prevention sheet 10 can be attached to the nipple by the adhesion part formed by adhesion between the first part and the second part. Furthermore, since the adhesion strength between the first part and the second part of the adhesive surface 12S is 10N / 25mm or less, when the tubular end of the mastitis prevention sheet 10 is blocked below the nipple orifice, it is possible to form a space capable of storing milk secreted from the nipple orifice.

[0030] The first portion of the adhesive surface 12S may be any area within the adhesive surface 12S, and the second portion may be an area different from the first portion and may be any area within the adhesive surface 12S other than the first portion.

[0031] The chitosan content in the adhesive layer 12 is preferably 5% by mass or less from the viewpoint of suppressing the amount of chitosan used while maintaining the antibacterial effect of chitosan. Therefore, the chitosan content in the adhesive layer 12 may be 2% by mass or more and 5% by mass or less. Alternatively, the chitosan content is preferably 5% by mass or more from the viewpoint of maintaining a high level of antibacterial activity value of chitosan and suppressing the variation in antibacterial activity value due to the variation in the chitosan content. Therefore, the chitosan content in the adhesive layer 12 may be 5% by mass or more and 10% by mass or less. The chitosan content is the percentage of the mass of chitosan with respect to the sum of the mass of the solid content in the base agent for forming the adhesive layer 12, the mass of the solid content in the curing agent for forming the adhesive layer 12, and the mass of chitosan.

[0032] The antibacterial effect of chitosan is confirmed by a method conforming to JIS Z 2801:2010 "Antibacterial processed products - Antibacterial test method, antibacterial effect." The adhesive strength of the adhesive layer 12 is a value measured by a tensile test conforming to JIS K 7127:1999 "Plastics - Test method for tensile properties - Part 3: Test conditions for films and sheets."

[0033] 1, the adhesive layer 12 is in contact with the base layer 11. The sheet body 10B constituted by the adhesive layer 12 and the base layer 11 may satisfy the following conditions. (Condition 3) The total light transmittance of the sheet body 10B is 30% or more.

[0034] If the total light transmittance of the sheet body 10B is 30% or more, when the sheet body 10B is attached to the nipple, it is possible to observe the nipple through the sheet body 10B. Therefore, after the sheet body 10B is attached to the nipple, it is possible to visually check the state of the nipple without peeling off the sheet body 10B. Therefore, since it is not necessary to peel off the sheet body 10B to visually check the state of the nipple, it is possible to prevent the sheet body 10B from peeling off easily from the nipple since there is no need to peel off a part of the sheet body 10B once attached to the nipple. In addition, if the total light transmittance of the sheet body 10B is 30% or more, it is also possible to check through the sheet body 10B whether milk secreted from the nipple orifice is present in the space formed by the sheet body 10B below the nipple orifice.

[0035] The total light transmittance of the sheet body 10B is a value measured by a method in accordance with JIS K 7361-1:1997 "Plastics-Test methods for total light transmittance of transparent materials-Part 1: Single beam method".

[0036] In the example shown in Fig. 1, the mastitis prevention sheet 10 further includes a protective layer 13 and a release layer 14. Of the above-mentioned base material layer 11, the surface opposite to the surface in contact with the adhesive layer 12 is the surface 11S. The protective layer 13 is in contact with the surface 11S of the base material layer 11. The protective layer 13 covers the entire base material layer 11. The release layer 14 is in contact with the adhesive surface 12S of the adhesive layer 12. The release layer 14 covers the entire adhesive layer 12.

[0037] FIG. 2 shows the planar structure of the mastitis prevention sheet 10 as viewed from a perspective opposite to the plane on which the mastitis prevention sheet 10 spreads. As shown in FIG. 2, the mastitis prevention sheet 10 has a flat plate shape before use. When viewed from a viewpoint opposite to the plane on which the mastitis prevention sheet 10 spreads, the mastitis prevention sheet 10 has a belt-shaped portion 10S along the outer edge 10E of the mastitis prevention sheet 10 and a through hole 10H located in the belt-shaped portion 10S. In the example shown in FIG. 2, the mastitis prevention sheet 10 has a plurality of through holes 10H. When the mastitis prevention sheet 10 has a through hole 10H, the number of the through holes 10H may be one or more, and is preferably a plurality. Each through hole 10H penetrates the mastitis prevention sheet 10 along the thickness direction of the mastitis prevention sheet 10. Each through hole 10H has a shape extending along the outer edge 10E of the mastitis prevention sheet 10.

[0038] When the mastitis prevention sheet 10 is attached to the nipple, the through hole 10H can be positioned below the nipple orifice, so that milk secreted from the nipple orifice can be discharged from the space surrounded by the mastitis prevention sheet 10 through the through hole 10H.

[0039] In an example of the mastitis prevention sheet 10 shown in FIG. 2, the outer edge 10E of the mastitis prevention sheet 10 has the same shape as the outer edge of the protective layer 13 when viewed from a viewpoint opposite to the plane on which the mastitis prevention sheet 10 spreads. The outer edge 10E of the mastitis prevention sheet 10 has a rectangular shape extending along the first direction D1, which is the longitudinal direction of the mastitis prevention sheet 10. The base layer 11, the adhesive layer 12, and the peeling layer 14 have a rectangular shape extending along the first direction D1, similar to the mastitis prevention sheet 10. The base layer 11, the adhesive layer 12, and the peeling layer 14 have the same shape. Therefore, in the following, the size of the protective layer 13 will be compared with the base layer 11, and a comparison of the size of the adhesive layer 12 and the peeling layer 14 with the size of the protective layer 13 will be omitted. In addition, in the following, the position of the base layer 11 relative to the protective layer 13 will be described, and a description of the position of the adhesive layer 12 and the peeling layer 14 relative to the protective layer 13 will be omitted.

[0040] The base layer 11 is smaller than the protective layer 13, and is located within the protective layer 13 when viewed from a viewpoint opposite the plane on which the mastitis prevention sheet 10 spreads. When viewed from a viewpoint opposite the plane on which the mastitis prevention sheet 10 spreads, a part of the outer edge of the base layer 11 overlaps a part of the outer edge of the protective layer 13. In the example shown in FIG. 2, the outer edge of the protective layer 13 is composed of a first long side, a second long side, a first short side, and a second short side. The first long side and the second long side extend along a first direction D1, and the first short side and the second short side extend along a second direction D2, which is the short side direction of the mastitis prevention sheet 10. The second direction D2 is a direction perpendicular to the first direction D1. When viewed from a viewpoint opposite to the plane on which the mastitis prevention sheet 10 spreads, the outer edge of the base material layer 11 overlaps with the first long side and parts of each short side of the outer edge of the protective layer 13. In the base material layer 11, the length LLS of the long side along the first direction D1 may be, for example, 100 mm or more and 150 mm or less. In the base material layer 11, the length LSS of the short side along the second direction D2 may be, for example, 50 mm or more and 100 mm or less.

[0041] The protective layer 13 includes a first region 13R1 and a second region 13R2. The second region 13R2 is a region of the protective layer 13 that contacts the base layer 11. In contrast, the first region 13R1 is a region of the protective layer 13 that does not contact the base layer 11. Each of the regions 13R1 and 13R2 extends along a first direction D1, and the first region 13R1 and the second region 13R2 are arranged side by side along a second direction D2. In the first region 13R1, the length along the second direction D2 may be, for example, 5 mm or more and 20 mm or less.

[0042] The above-mentioned belt-shaped portion 10S is located in the second region 13R2 of the protective layer 13. That is, the belt-shaped portion 10S includes part of the protective layer 13, part of the base layer 11, part of the adhesive layer 12, and part of the peeling layer 14 of the mastitis prevention sheet 10. Therefore, each through-hole 10H located in the belt-shaped portion 10S penetrates the protective layer 13, the base layer 11, the adhesive layer 12, and the peeling layer 14 in the thickness direction of the mastitis prevention sheet 10.

[0043] The strip-shaped portion 10S has a shape along the first long side of the outer edge of the protective layer 13 and extends along the first direction D1. In the example shown in FIG. 2, the strip-shaped portion 10S is located on the opposite side of the first region 13R1 of the protective layer 13 with respect to the center of the mastitis prevention sheet 10 in the second direction D2. In the strip-shaped portion 10S, the multiple through holes 10H are arranged at equal intervals along the first direction D1. The intervals between the through holes 10H may include intervals having a first length and intervals having a second length different from the first length. That is, in the example shown in FIG. 2, the multiple through holes 10H are arranged regularly, but the multiple through holes 10H may be arranged irregularly.

[0044] 2, the multiple through holes 10H are composed of through holes 10H included in a first row 10HL1 and through holes 10H included in a second row 10HL2. Each row 10HL1, 10HL2 extends along a first direction D1, and the first row 10HL1 and the second row 10HL2 are arranged at intervals in the second direction D2. The through holes 10H belonging to the first row 10HL1 and the through holes 10H belonging to the second row 10HL2 are arranged in a staggered arrangement in one array composed of the first row 10HL1 and the second row 10HL2.

[0045] When viewed from a viewpoint facing the plane on which the mastitis prevention sheet 10 spreads, the length L10H of the through hole 10H may be 1 mm or more and 4 mm or less. In the example shown in Fig. 2, the length L10H of the through hole 10H in the first direction D1 may be 1 mm or more and 4 mm or less. When the length of the through hole 10H is 1 mm or more and 4 mm or less, it is possible to increase the reliability with which the mastitis prevention sheet 10 adheres to the nipple and to increase the reliability with which milk is discharged through the through hole 10H.

[0046] The mastitis prevention sheet 10 may have the structure shown in Figures 3 to 5, which are referred to below. Figures 3 to 5 show the planar structure of the mastitis prevention sheet 10 as viewed from a viewpoint opposite to the plane on which each mastitis prevention sheet 10 spreads.

[0047] The mastitis prevention sheet 10 of the first modified example shown in FIG. 3 has a different external shape from the mastitis prevention sheet 10 shown in FIG. As shown in FIG. 3, the mastitis prevention sheet 10 may have a trapezoid shape. The protective layer 13 has a trapezoid shape, and in the protective layer 13, a pair of short sides extending along the second direction D2 are parallel to each other. The base layer 11 has a trapezoid shape similar to the protective layer 13, and in the base layer 11, a pair of short sides extending along the second direction D2 are parallel to each other. The adhesive layer 12 and the peeling layer 14 have the same shape as the base layer 11. In the protective layer 13, the first region 13R1 and the second region 13R2 are arranged along the second direction D2. In the protective layer 13, the second region 13R2 has a trapezoid shape, and the first region 13R1 has a parallelogram shape along one long side of the second region 13R2.

[0048] The mastitis prevention sheet 10 of the second modified example shown in FIG. 4, like the mastitis prevention sheet 10 shown in FIG. 3, has a different external shape from the mastitis prevention sheet 10 shown in FIG.

[0049] As shown in FIG. 4, the mastitis prevention sheet 10 has a substantially trapezoidal shape. However, in the mastitis prevention sheet 10, each long side of the protective layer 13 has a bending point at the boundary between the first region 13R1 and the second region 13R2. In the protective layer 13, the first region 13R1 and the second region 13R2 are arranged along the first direction D1. The first region 13R1 and the second region 13R2 each have a trapezoidal shape. The first region 13R1 has a trapezoidal shape that tapers more steeply than the second region 13R2 along the direction from the second region 13R2 to the first region 13R1 in the first direction D1. The second region 13R2 has a trapezoidal shape that tapers along the direction from the second region 13R2 to the first region 13R1 in the first direction D1.

[0050] The base layer 11 has a trapezoidal shape overlapping the second region 13R2 of the protective layer 13 when viewed from a perspective facing the plane on which the mastitis prevention sheet 10 spreads. The adhesive layer 12 and the release layer 14 have the same shape as the base layer 11.

[0051] The mastitis prevention sheet 10 of the third modified example shown in FIG. 5 differs from the mastitis prevention sheet 10 shown in FIG. 2 in that the protective layer 13 of the mastitis prevention sheet 10 has a slit 13B.

[0052] As shown in FIG. 5, the protective layer 13 has two slits 13B in the first region 13R1. Each slit 13B extends from the outer edge of the protective layer 13 toward the base layer 11. The slits 13B have a length that does not reach the base layer 11. In the example shown in FIG. 5, each slit 13B extends along the second direction D2. Since the protective layer 13 has the slits 13B, when peeling the protective layer 13 from the base layer 11, it is possible to peel the protective layer 13 from the base layer 11 by splitting the protective layer 13 along the slits 13B. Therefore, it is easy to peel the protective layer 13 from the base layer 11.

[0053] The distance D13B between the slits 13B in the first direction D1 may be, for example, 3 mm or more and 40 mm or less. This makes it easy to pick up the portion located between the slits 13B. The center of the mastitis prevention sheet 10 in the first direction D1 may be located between the slits 13B. This makes it possible to split the protective layer 13 approximately in the center in the first direction D1 by splitting the protective layer 13 along the slits 13B.

[0054] The mastitis prevention sheet 10 may have only one slit 13B, or may have three or more. The mastitis prevention sheet 10 of the first modified example may also have a slit 13B. In this case, the mastitis prevention sheet 10 may have a slit 13B located in the first region 13R1 of the protective layer 13 and extending, for example, along the second direction D2. The mastitis prevention sheet of the second modified example may also have a slit 13B. In this case, the mastitis prevention sheet 10 may have a slit 13B located in the first region 13R1 of the protective layer 13 and extending, for example, along the first direction D1.

[0055] [How to use the mastitis prevention sheet] A method of using the mastitis prevention sheet 10 will be described with reference to Figures 6 to 10. Below, a method of using the mastitis prevention sheet 10 will be described when attaching the mastitis prevention sheet 10 to the nipples of a dairy cow, which is an example of a livestock. The method of using the mastitis prevention sheet 10 includes attaching the mastitis prevention sheet 10 to the nipple so that the mastitis prevention sheet 10 has a tubular shape that surrounds the nipple, and closely adhering a first portion of the adhesive surface 12S to a second portion of the adhesive surface at a position away from the nipple opening of the nipple so as to close the tubular end of the mastitis prevention sheet 10.

[0056] According to the method of using the mastitis prevention sheet 10 of the present disclosure, the mastitis prevention sheet 10 is attached to the nipple so as to have a tubular shape surrounding the nipple. This makes it difficult for milk secreted from the nipple opening to spread between the adhesive surface 12S and the nipple. Also, since the first part of the adhesive surface 12S adheres to the second part at a position away from the nipple opening, milk secreted from the nipple opening is unlikely to remain between the adhesive surface 12S and the nipple opening. Therefore, the adhesive layer is unlikely to peel off from the nipple, and as a result, the mastitis prevention sheet 10 is unlikely to peel off from the nipple. The method of using the mastitis prevention sheet 10 will be described in more detail below with reference to the drawings.

[0057] As shown in Figure 6, when using the mastitis prevention sheet 10, after peeling off the release layer 14 from the adhesive layer 12, a part of the adhesive surface 12S is attached to the nipple N of the dairy cow C. This positions the mastitis prevention sheet 10 relative to the nipple N. At this time, the mastitis prevention sheet 10 is positioned relative to the nipple N so that the through-holes 10H of the mastitis prevention sheet 10 are located away from the nipple orifice NA located at the tip of the nipple N. In other words, the mastitis prevention sheet 10 is positioned relative to the nipple N so that the through-holes 10H of the mastitis prevention sheet 10 are located below the nipple orifice NA.

[0058] Next, as shown in Fig. 7, the mastitis prevention sheet 10 is folded so that the adhesive surface 12S of the mastitis prevention sheet 10 surrounds the nipple N, thereby adhering the third portion 12S3 of the adhesive surface 12S to the fourth portion 12S4 of the adhesive surface 12S. This causes the mastitis prevention sheet 10 to be attached to the nipple N so that the flat mastitis prevention sheet 10 has a cylindrical shape surrounding the nipple N. The adhered portion formed by adhering the third portion 12S3 of the adhesive surface 12S to the fourth portion 12S4 is likely to be located outside the nipple N in the radial direction of the nipple N, and is unlikely to be located below the nipple orifice NA. Therefore, the adhered portion is unlikely to come into contact with milk secreted from the nipple orifice NA.

[0059] 8, the protective layer 13 is peeled off from the base layer 11. At this time, for example, a user of the mastitis prevention sheet 10 grips the first region 13R1 of the protective layer 13. Next, the user turns the protective layer 13 away from the base layer 11 along the direction from the first region 13R1 toward the second region 13R2, thereby peeling the protective layer 13 off from the base layer 11. After peeling the protective layer 13 from the base layer 11, the user preferably grips a cylindrical portion of the mastitis prevention sheet 10 surrounding the nipple N, thereby bringing the cylindrical portion into close contact with the nipple N.

[0060] As shown in Fig. 9, the first portion 12S1 of the adhesive surface 12S is adhered to the second portion 12S2 of the adhesive surface 12S at a position away from the nipple orifice NA of the nipple N so as to close the tubular end 10TE of the sheet body 10B of the mastitis prevention sheet 10. In this way, according to the method of using the mastitis prevention sheet 10 of the present disclosure, the mastitis prevention sheet 10 is attached to the nipple N so as to have a tubular shape surrounding the nipple N. As a result, the adhesive portion formed by adhering the fourth portion 12S4 to the third portion 12S3 of the adhesive surface 12S is less susceptible to milk secreted from the nipple orifice NA, so the adhesive layer 12 is less likely to peel off from the nipple N. Therefore, the sheet body 10B of the mastitis prevention sheet 10 is less likely to peel off from the nipple N.

[0061] Since the adhesion strength on the adhesive surface 12S is approximately constant within the adhesive surface 12S, the adhesion strength between the first portion 12S1 and the second portion 12S2 is equal to the adhesion strength between the third portion 12S3 and the fourth portion 12S4.

[0062] At this time, the mastitis prevention sheet 10 may be attached to the nipple N so that the through-hole 10H is located at the tubular end 10TE of the sheet body 10B. In this case, since the through-hole 10H is located at the tubular end 10TE of the sheet body 10B, it is possible for milk secreted from the nipple N to be discharged from the through-hole 10H at the tubular end 10TE to the outside of the space surrounded by the sheet body 10B.

[0063] When closing the cylindrical end 10TE of the sheet body 10B, the contact portion formed by adhering the third portion 12S3 of the adhesive surface 12S to the fourth portion 12S4 may be wrapped around the nipple N. This prevents the contact portion from protruding in the radial direction of the nipple N, thereby preventing the contact portion from getting caught on an obstacle, for example. This prevents the sheet body 10B from coming off the nipple N.

[0064] As shown in Fig. 10, the method of using the mastitis prevention sheet 10 may further include discharging milk M from the through-hole 10H located at the tube end 10TE of the sheet body 10B. When discharging milk M from the through-hole 10H, the user of the mastitis prevention sheet 10 may grasp the sheet body 10B together with the nipple N of the dairy cow C to cause milk M to be discharged from the space surrounded by the sheet body 10B to the outside. Alternatively, milk M secreted from the nipple opening NA into the space surrounded by the sheet body 10B may seep out from the through-hole 10H due to its own weight. In this case, the sheet body 10B becomes even more difficult to peel off from the nipple N compared to the case where milk M secreted from the nipple opening NA continues to remain in the space surrounded by the sheet body 10B.

[0065] [Manufacturing method of mastitis prevention sheet] A method for producing the mastitis prevention sheet 10 will be described with reference to Figures 11 to 13. When producing the mastitis prevention sheet 10, the base material layer 11 and the adhesive layer 12 of the mastitis prevention sheet 10 are formed separately, and then the adhesive layer 12 is bonded to the base material layer 11. Below, the process for producing the base material layer 11 will be described with reference to Figure 11, the process for producing the adhesive layer 12 will be described with reference to Figure 12, and the process for producing the mastitis prevention sheet 10 by bonding the adhesive layer 12 to the base material layer 11 will be described with reference to Figure 13.

[0066] As shown in FIG. 11, the process of preparing the substrate layer 11 includes a first coating film forming step (step S11), a drying step (step S12), and an aging step (step S13). In detail, a first coating film is formed using a first coating liquid for forming the substrate layer 11 (step S11). At this time, the first coating film is formed on one surface of the protective layer 13. Next, the first coating film is dried (step S12). The thickness of the first coating film after drying may be, for example, 5 μm or more and 30 μm or less. Thereafter, the first coating film is aged to obtain the substrate layer 11 from the first coating film, and as a result, it is possible to obtain a first laminate composed of the substrate layer 11 and the protective layer 13 (step S13). The thickness of the substrate layer 11 obtained after aging is equal to the thickness of the first coating film after drying.

[0067] The protective layer 13 is formed of a synthetic resin. The protective layer 13 may be formed of, for example, a base sheet and a release layer. In this case, the release layer is laminated on the base sheet. When the protective layer 13 includes a base sheet and a release layer, the release layer is in contact with the base layer 11. The base sheet may be formed of, for example, either a polyolefin resin or a polyester resin. The polyester resin may be, for example, a polyethylene terephthalate resin. The polyolefin resin may be, for example, a polypropylene resin. The base sheet is preferably formed of a polyolefin resin. The base sheet may be any of a uniaxially oriented sheet, a biaxially oriented sheet, and a non-oriented sheet. The release layer may be formed of, for example, a silicone resin.

[0068] The protective layer 13 may be composed of only the above-mentioned base sheet. In this case, the contact surface of the base sheet that contacts the base layer 11 may be processed to facilitate peeling of the base layer 11 from the base sheet. The processing of the contact surface of the base sheet may be, for example, embossing. The thickness of the protective layer 13 may be, for example, not less than 30 μm and not more than 400 μm.

[0069] The base layer 11 is made of a synthetic resin. The synthetic resin for forming the base layer 11 may be, for example, a polyurethane resin. The polyurethane resin may be an aqueous polyurethane. This makes it possible to obtain a base layer 11 that is highly suitable for application to the skin. The thickness of the base layer 11 may be, for example, 5 μm or more and 30 μm or less. The base layer 11, which is made of a polyurethane resin and is thin, stretches well even when a small external force is applied to the base layer 11 to stretch the base layer 11. Therefore, the base layer 11 has high conformability to the nipple, which is the object to which the sheet body 10B is applied, and can have high adhesion to the nipple.

[0070] The thickness of the base layer 11 may be, for example, 5 μm or more and 30 μm or less. The tensile elongation at break of the base layer 11 may be, for example, 130% or more. The tensile elongation at break can be determined in accordance with JIS K 7161-1:2014 (ISO 527-1) "Plastics - Determination of tensile properties - Part 1: General rules" and JIS K 7127:1999 (ISO 527-3) "Plastics - Test methods for tensile properties - Part 3: Test conditions for films and sheets". When the measurement object does not have a yield point, the tensile breaking strain is measured, and when the measurement object has a yield point, the nominal tensile strain at break is measured, and the tensile breaking elongation can be determined using these measured values.

[0071] The 100% elongation tensile strength of the base layer 11 may be, for example, 4 N / cm or less. The 100% elongation tensile strength is the value obtained by dividing the magnitude of the force measured when the strain reaches a specified value (100%) as defined in JIS K 7161-1:2014 (ISO 527-1) "Plastics - Determination of tensile properties - Part 1: General" by the width of the test piece. The 100% elongation tensile strength (T) (N / cm) can be calculated by the following formula.

[0072] T = F / W In the above formula, F is the magnitude of the measured force (N) and W is the width of the test piece (cm).

[0073] The base layer 11 may be made of a synthetic resin other than polyurethane resin. The synthetic resin other than polyurethane resin may be, for example, polyvinylidene fluoride resin, ethylene-vinyl acetate copolymer resin, polypropylene resin, polyethylene terephthalate resin, or the like.

[0074] As shown in FIG. 12, the process of preparing the adhesive layer 12 includes an acidic aqueous solution preparation step (step S21), a second coating liquid preparation step (step S22), a second coating film formation step (step S23), and a drying step (step S24). In detail, when forming the adhesive layer 12, first, an acidic aqueous solution containing chitosan is prepared (step S21). Next, a second coating liquid for forming the adhesive layer 12 is prepared using an acidic aqueous solution containing a main agent of the adhesive for forming the adhesive layer 12, a curing agent of the adhesive, and chitosan (step S22). Since the acidic aqueous solution containing chitosan is prepared before mixing the main agent with the adhesive, it is possible to make the chitosan molecules exist uniformly in the second coating liquid. As a result, the chitosan molecules exist uniformly in the adhesive layer formed using the second coating liquid. The second coating liquid may contain a solvent different from the acidic aqueous solution. In this case, it is possible to adjust the viscosity of the second coating liquid by a solvent other than the acidic aqueous solution.

[0075] In this way, the adhesive layer 12 is formed by mixing an acidic aqueous solution containing chitosan with the base agent and curing agent contained in the adhesive. Chitosan is soluble in an acidic aqueous solution, and in the acidic aqueous solution, the amino group of chitosan has a positive charge, which allows chitosan to have antibacterial activity. As described above, chitosan dissolved in an acidic aqueous solution and having antibacterial activity is used to form the adhesive layer 12, so that the adhesive layer 12 can contain chitosan having antibacterial activity. The acidic aqueous solution that dissolves the chitosan powder may contain an inorganic acid or an organic acid. The inorganic acid may be, for example, hydrochloric acid, nitric acid, sulfuric acid, or the like. The organic acid may be, for example, formic acid, acetic acid, lactic acid, citric acid, or the like.

[0076] Next, a second coating film is formed on one surface of the release layer 14 using the second coating liquid (step S23). The second coating film is then dried to obtain the adhesive layer 12 from the second coating film (step S24). This results in the adhesive layer 12 satisfying the above-mentioned conditions 1 and 2. Since the second coating liquid for forming the adhesive layer 12 contains an acidic compound, the adhesive layer 12 formed using the second coating liquid also contains an acidic compound. The thickness of the adhesive layer 12 may be, for example, 5 μm or more and 30 μm or less. According to this method for forming the adhesive layer 12, it is possible to increase the certainty that the chitosan has an antibacterial effect in the adhesive layer 12 containing 2 mass % or more of chitosan.

[0077] The peeling layer 14 may be configured so that the peel strength between the peeling layer 14 and the adhesive layer 12 is smaller than the peel strength between the protective layer 13 and the base layer 11. The peeling layer 14 is made of a synthetic resin. The peeling layer 14 is made of, for example, a base sheet and a release layer. The release layer is laminated on the base sheet. When the peeling layer 14 includes a base sheet and a release layer, the release layer is in contact with the adhesive layer 12. The base sheet may be made of, for example, a polyethylene terephthalate resin. The base sheet may be any one of a uniaxially oriented sheet, a biaxially oriented sheet, and a non-oriented sheet. The release layer may be made of, for example, a silicone resin.

[0078] The release layer 14 may be composed of only the above-mentioned base sheet. In this case, the contact surface of the base sheet that contacts the adhesive surface 12S of the adhesive layer 12 may be processed to facilitate peeling of the adhesive layer 12 from the base sheet. The processing of the contact surface of the base sheet may be, for example, embossing. The thickness of the release layer 14 may be, for example, not less than 12 μm and not more than 350 μm.

[0079] The adhesive layer 12 may be formed from various adhesives. The adhesive for forming the adhesive layer 12 may be, for example, any one of a rubber-based adhesive, an acrylic-based adhesive, a silicone-based adhesive, and a urethane-based adhesive. The adhesive layer 12 may be formed from a two-liquid mixed adhesive. The thickness of the adhesive layer 12 may be, for example, 5 μm or more and 30 μm or less. In the adhesive layer 12, when the adhesion strength between the first portion 12S1 and the second portion 12S2 of the adhesive surface 12S is changed from a first value to a second value, for example, the adhesive forming the adhesive layer 12 may be changed from a first material to a second material. In addition, the adhesion strength of the adhesive layer 12 tends to increase as the thickness of the adhesive layer 12 is increased. In addition, the adhesion strength of the adhesive layer 12 tends to decrease by drying the adhesive layer 12 and then aging the adhesive layer 12 in an environment at a higher temperature than when the adhesive layer 12 was dried. When aging the adhesive layer 12, for example, the adhesive layer 12 may be left to stand in an environment at 80° C. for 7 days or more.

[0080] Chitosan may be a powder. The maximum particle size of chitosan may be, for example, 50 μm or less. From the viewpoint of suppressing recovery of chitosan on the plate used for coating the second coating film, the maximum particle size of chitosan is preferably smaller than the thickness of the second coating film before drying. From the viewpoint of making it easier for the chitosan contained in the adhesive layer 12 to come into contact with the nipples N, the maximum particle size of chitosan is preferably larger than the thickness of the adhesive layer 12 formed by drying the second coating film. The maximum particle size of chitosan can be grasped, for example, by the size of the openings of a sieve used to separate the chitosan.

[0081] As shown in FIG. 13, the process of obtaining the mastitis prevention sheet 10 from the first laminate and the second laminate includes a bonding step (step S31) and an aging step (step S32). In detail, when obtaining the mastitis prevention sheet 10, first, the adhesive layer 12 of the second laminate is bonded to the base layer 11 of the first laminate (step S31). Next, the laminate composed of the first laminate and the second laminate is aged (step S32). In this way, the mastitis prevention sheet 10 can be obtained. In the obtained mastitis prevention sheet 10, the protective layer 13, the base layer 11, the adhesive layer 12, and the peeling layer 14 are laminated in the order described above.

[0082] [Test example] A test example will be described with reference to FIGS. [Test Example 1] [Test Example 1-1] A biaxially oriented polypropylene (OPP) film (Futamura Chemical Co., Ltd., FOR-MP) was prepared as a protective layer, one of a pair of surfaces facing each other in the thickness direction, with one surface being a matte surface. Then, a first coating liquid, an aqueous polyurethane containing an ether-based polyol (Mitsui Chemical Co., Ltd., Takelac WS-6021) (Takelac is a registered trademark), was applied to the matte surface of the OPP film, thereby forming a first coating film. Next, the first coating film was dried to obtain a first coating film after drying with a thickness of 15 μm. Next, the first coating film after drying was aged at room temperature for 48 hours to obtain a base layer. This resulted in a first laminate consisting of a protective layer and a base layer.

[0083] A release film (Toray Film Processing Co., Ltd., Therapeel WZ) (Therapeel is a registered trademark) consisting of a polyethylene terephthalate (PET) film and a release layer was prepared as a release layer. In addition, a urethane adhesive (Toyochem Co., Ltd., SP-205), a curing agent (Toyochem Co., Ltd., T-501B), and a dilution solvent (Toyo Ink Co., Ltd., NC401 Solvent C) were prepared as the main agent. In addition, chitosan powder (Hokkaido Soda Co., Ltd., chitosan powder, deacetylation degree 83.5%, molecular weight about 220,000) selected with a 0.6 mm sieve was dispersed in water so that the mass of the chitosan powder was 5 mass%, thereby obtaining a chitosan aqueous solution. Next, in order to dissolve the chitosan powder, acetic acid of the same mass as the chitosan powder was added to the chitosan aqueous solution to prepare an acetic acid aqueous solution containing chitosan.

[0084] When the sum of the mass of the solid content in the base agent, the mass of the chitosan, and the mass of the solid content in the curing agent is 100 mass%, an aqueous acetic acid solution containing chitosan was added to the base agent so that the mass of chitosan was 2 mass%, and then the base agent and the aqueous acetic acid solution containing chitosan were mixed. Next, a dilution solvent was added to the first mixture of the base agent and the aqueous acetic acid solution containing chitosan to adjust the viscosity of the second mixture consisting of the base agent, the aqueous acetic acid solution containing chitosan, and the solvent. Next, a curing agent was added to the second mixture, and the second mixture to which the curing agent was added was stirred to obtain a second coating liquid for forming an adhesive layer.

[0085] Next, the second coating liquid was applied to the release layer of the release film to obtain a second coating film. At this time, the coating amount of the second coating liquid was 100 g / m 2 The second coating film was then dried to obtain an adhesive layer having a thickness of 15 μm, thereby obtaining a second laminate composed of a release layer and an adhesive layer.

[0086] The adhesive layer of the second laminate was attached to the base layer of the first laminate to obtain a laminate. The laminate had a layer structure in which a protective layer, a base layer, an adhesive layer, and a release layer were laminated in the order described above. The laminate was then aged at 50°C for 72 hours to obtain a mastitis prevention sheet of Test Example 1-1.

[0087] [Test Example 1-2] A mastitis prevention sheet of Test Example 1-2 was obtained in the same manner as Test Example 1-1, except that an aqueous acetic acid solution containing chitosan was added to the main ingredient so that the mass of chitosan was 5 mass%.

[0088] [Test Example 1-3] A mastitis prevention sheet of Test Example 1-3 was obtained in the same manner as Test Example 1-1, except that an aqueous acetic acid solution containing chitosan was added to the main ingredient so that the mass of chitosan was 10 mass%.

[0089] [Test Example 1-4] An external nipple seal (Teetoner, manufactured by Tokuyama Corporation) (Teetoner is a registered trademark) was used as the mastitis prevention sheet in Test Examples 1-4. In the external nipple seal, a transparent film, a urethane layer, an adhesive layer formed from butyl acrylate, and a release paper were laminated in the order shown.

[0090] [Test Example 1-5] A mastitis prevention sheet of Test Example 1-5 was obtained in the same manner as Test Example 1-1, except that an aqueous acetic acid solution containing chitosan was added to the main ingredient so that the mass of chitosan was 0.1 mass%.

[0091] [Test Example 1-6] A mastitis prevention sheet of Test Example 1-6 was obtained in the same manner as Test Example 1-1, except that an aqueous acetic acid solution containing chitosan was added to the main ingredient so that the mass of chitosan was 1 mass%.

[0092] [Test Example 1-7] A mastitis prevention sheet of Test Example 1-7 was obtained by the same method as Test Example 1-1, except that the method of forming the adhesive layer in Test Example 1-1 was changed as follows. In Test Example 1-7, a release film (same as above) was prepared as a peeling layer when forming the adhesive layer. In addition, a urethane adhesive (same as above) as a base agent, a curing agent (same as above), and fibrous chitosan (manufactured by Hokkaido Soda Co., Ltd.) were prepared. Next, chitosan was added to the base agent so that the mass of chitosan was 30 mass% when the sum of the mass of the solid content in the base agent, the mass of chitosan, and the mass of the curing agent was 100 mass%, and then the base agent and chitosan were mixed to obtain a first mixture. A curing agent was added to the first mixture, and then the first mixture to which the curing agent was added was stirred to obtain a second coating liquid for forming an adhesive layer.

[0093] Next, the second coating liquid was applied to the release layer of the release film to obtain a second coating film. At this time, the coating amount of the second coating liquid was 100 g / m 2 The second coating film was then dried to obtain an adhesive layer having a thickness of 15 μm, thereby obtaining a second laminate composed of a release layer and an adhesive layer.

[0094] [Test Example 1-8] A mastitis prevention sheet of Test Example 1-8 was obtained in the same manner as Test Example 1-1, except that the method of forming the adhesive layer in Test Example 1-1 was changed as follows. In Test Example 1-8, a release film (same as above) was prepared as a peeling layer when forming the adhesive layer. In addition, a urethane adhesive (same as above) as a base agent and a hardener (same as above) were prepared. Next, the hardener was added to the base agent, and the base agent to which the hardener was added was stirred to obtain a second coating liquid for forming the adhesive layer.

[0095] Next, the second coating liquid was applied to the release layer of the release film to obtain a second coating film. At this time, the coating amount of the second coating liquid was 100 g / m 2 The second coating film was then dried to obtain an adhesive layer having a thickness of 15 μm, thereby obtaining a second laminate composed of a release layer and an adhesive layer.

[0096] [Test Example 1-9] A mastitis prevention sheet of Test Example 1-9 was obtained by the same method as Test Example 1-1, except that the method of forming the adhesive layer was changed as follows. In Test Example 1-9, a release film (same as above) was prepared as a peeling layer when forming the adhesive layer. In addition, a urethane adhesive (same as above), a curing agent (same as above), and chitosan powder (same as above) were prepared as the main agent. Next, chitosan was added to the main agent so that the mass of chitosan was 10 mass% when the sum of the mass of the solid content in the main agent, the mass of chitosan, and the mass of the solid content in the curing agent was 100 mass%, and then the main agent and chitosan were mixed to obtain a first mixture. A curing agent was added to the first mixture, and then the first mixture to which the curing agent was added was stirred to obtain a second coating liquid for forming an adhesive layer.

[0097] Next, the second coating liquid was applied to the release layer of the release film to obtain a second coating film. At this time, the coating amount of the second coating liquid was 100 g / m 2 The second coating liquid was then dried to obtain an adhesive layer having a thickness of 15 μm, thereby obtaining a second laminate composed of the release layer and the adhesive layer.

[0098] [Evaluation method] [Adhesion strength] When measuring the adhesion strength between the first and second parts on the adhesive surface, two second laminates consisting of a peeling layer and an adhesive layer were prepared for each mastitis prevention sheet of the test example. Then, a test piece was prepared by attaching the adhesive layer of the second second laminate to the adhesive layer of the first second laminate. Then, the adhesion strength between the two adhesive layers of the test piece was measured by a tensile test in accordance with JIS K 7127:1999 "Plastics - Test method for tensile properties - Part 3: Test conditions for films and sheets". At this time, an autograph tester (Shimadzu Corporation, Autograph AGS-X load cell 1kN) (Autograph is a registered trademark) was used as the tensile tester, and the test speed was set to 300 mm / min. In addition, three test pieces were prepared for each mastitis prevention sheet of the test example, and the average value of the adhesion strength of the three test pieces was set as the adhesion strength of each test example.

[0099] [Peel strength] The peel strength between the base layer and the protective layer of the mastitis prevention sheet of each test example was measured. At this time, the peel strength between the base layer and the protective layer was measured by the same method as that used to measure the adhesion strength on the adhesive surface. That is, the peel strength between the base layer and the protective layer of the mastitis prevention sheet was measured by a tensile test in accordance with JIS K 7127:1999 "Plastics - Test methods for tensile properties - Part 3: Test conditions for films and sheets". At this time, an autograph tester (same as above) was used as the tensile tester, and the test speed was set to 300 mm / min. For each mastitis prevention sheet of each test example, three sheets were prepared, and the average value of the peel strengths of the three sheets was set as the peel strength of each test example.

[0100] [Adhesive strength] The adhesive strength of the adhesive layer of each test example of the mastitis prevention sheet was measured. At this time, the adhesive strength of the adhesive layer to the SUS plate was measured by the same method as that for measuring the adhesion strength of the adhesive surface. That is, the adhesive strength of the adhesive layer in the mastitis prevention sheet was measured by a tensile test in accordance with JIS K 7127:1999 "Plastics - Test methods for tensile properties - Part 3: Test conditions for films and sheets". At this time, an autograph tester (same as above) was used as the tensile tester, and the test speed was set to 300 mm / min. For each test example of the mastitis prevention sheet, three sheets were prepared, and the average value of the adhesive strengths of the three sheets was set as the adhesive strength of each test example.

[0101] [Total light transmittance] A laminate of the base material layer and the adhesive layer of the mastitis prevention sheet of each test example was formed on a paper frame to form a test piece for the mastitis prevention sheet of each test example. The total light transmittance of the test piece was measured by a method conforming to JIS K 7361-1:1997 "Plastics - Test method for total light transmittance of transparent materials - Part 1: Single beam method". At this time, a haze meter (Murakami Color Research Institute Co., Ltd., Haze meter HM-150) was used. Three test pieces were prepared for each mastitis prevention sheet of the test example, and the average value of the total light transmittance of the three test pieces was set as the total light transmittance of each test example.

[0102] [Applicability] The mastitis prevention sheet of each test example was attached to the silicon nipple of a milk bottle for dairy cows. At this time, the mastitis prevention sheet of each test example was attached to the silicon nipple by the method of use described above with reference to Figures 6 to 9. The attachment property of the mastitis prevention sheet of each test example when attached to the silicon nipple was evaluated according to the following two stages.

[0103] The mastitis prevention sheet could be attached to the silicone nipple with a space below the nipple opening in which water supplied from the baby bottle could remain. ×: There was a space below the nipple opening of the silicone nipple, and the mastitis prevention sheet could not be attached to the silicone nipple.

[0104] [Antibacterial effect] The antibacterial activity value against Escherichia coli of each test example mastitis prevention sheet was measured using a method in accordance with JIS Z 2801:2010 "Antibacterial processed products - Antibacterial test method, antibacterial effect." The antibacterial effect of each mastitis prevention sheet was evaluated using the following two-level scale.

[0105] ○ The antibacterial activity value is 2.0 or higher, and the mastitis prevention sheet has antibacterial effects. × The antibacterial activity value is less than 2.0, and the mastitis prevention sheet has no antibacterial effect.

[0106] [Evaluation Results] The evaluation results of each mastitis prevention sheet in terms of adhesion strength, peel strength, adhesive strength, total light transmittance, application property, and antibacterial effect are shown in Figure 14. As shown in Figure 14, the adhesive strength of the adhesive layer was found to be 3.7 N / 25 mm in Test Example 1-1, 3.1 N / 25 mm in Test Example 1-2, and 2.9 N / 25 mm in Test Example 1-3. The adhesive strength of the adhesive layer was found to be 11.6 N / 25 mm in Test Example 1-4, 3.4 N / 25 mm in Test Example 1-5, and 2.6 N / 25 mm in Test Example 1-6. The adhesive strength of the adhesive layer was found to be 1.3 N / 25 mm in Test Example 1-7, 2.2 N / 25 mm in Test Example 1-8, and 3.1 N / 25 mm in Test Example 1-9.

[0107] The peel strength between the base layer and the protective layer was found to be 0.08 N / 25 mm in Test Example 1-1, 0.09 N / 25 mm in Test Example 1-2, and 0.09 N / 25 mm in Test Example 3. The peel strength between the base layer and the protective layer was found to be 0.10 N / 25 mm in Test Example 1-4, 0.08 N / 25 mm in Test Example 1-5, and 0.08 N / 25 mm in Test Example 1-6. The peel strength between the base layer and the protective layer was found to be 0.12 N / 25 mm in Test Example 1-7, 0.08 N / 25 mm in Test Example 1-8, and 0.08 N / 25 mm in Test Example 1-9.

[0108] The adhesive strength of the adhesive layer was found to be 5.5 N / 25 mm in Test Example 1-1, 4.4 N / 25 mm in Test Example 1-2, and 6.0 N / 25 mm in Test Example 1-3. The adhesive strength of the adhesive layer was found to be 7.2 N / 25 mm in Test Example 1-4, 5.5 N / 25 mm in Test Example 1-5, and 6.4 N / 25 mm in Test Example 1-6. The adhesive strength of the adhesive layer was found to be 1.9 N / 25 mm in Test Example 1-7, 3.8 N / 25 mm in Test Example 1-8, and 3.4 N / 25 mm in Test Example 1-9.

[0109] The total light transmittance in the sheet body was found to be 92.0% in Test Example 1-1, 92.1% in Test Example 1-2, and 92.0% in Test Example 3. The total light transmittance in the sheet body was found to be 28.5% in Test Example 1-4, 92.1% in Test Example 1-5, and 92.1% in Test Example 1-6. The total light transmittance in the sheet body was found to be 79.8% in Test Example 1-7, 92.0% in Test Example 1-8, and 91.5% in Test Example 1-9.

[0110] The application of the mastitis prevention sheet was evaluated as "○" in Test Examples 1-1 to 1-3, 1-5, 1-6, 1-8, and 1-9, and as "×" in Test Examples 1-4 and 1-7.

[0111] The antibacterial effect of the mastitis prevention sheet was found to be "○" in Test Examples 1-1 to 1-3, and "×" in Test Examples 1-5 to 1-9. In detail, the antibacterial activity value of Test Example 1-1 was 4.4, the antibacterial activity value of Test Example 1-2 was 6.2, and the antibacterial activity value of Test Example 1-3 was 6.1. The antibacterial activity value of Test Example 1-4 was not measurable, the antibacterial activity value of Test Example 1-5 was 1.0, and the antibacterial activity value of Test Example 1-6 was 0.8. The antibacterial activity value of Test Example 1-7 was 0.0, and the antibacterial activity value of Test Example 1-9 was -0.2. In calculating the antibacterial activity value, the test result of Test Example 1-8, which does not contain chitosan, was set as the control.

[0112] Thus, it was found that in the mastitis prevention sheets of Test Examples 1-1 to 1-3, both the application property and the antibacterial effect were rated as "○", while in the mastitis prevention sheets of Test Examples 1-4 to 1-6, at least one of the application property and the antibacterial effect was rated as "×".

[0113] That is, it was confirmed that the sheet has suitable adhesion when the adhesion strength is within the range of 2.6N / 25mm to 3.7N / 25mm. It was also confirmed that the protective layer can be peeled off from the base layer when the peel strength is within the range of 0.08N / 25mm to 0.10N / 25mm. It was also confirmed that the mastitis prevention sheet can be attached to the nipple in a cylindrical shape surrounding the nipple when the adhesive strength is within the range of 3.4N / 25mm to 7.2N / 25mm.

[0114] In addition, it was confirmed that the condition of the nipples could be visually observed through the sheet body attached to the nipples in the mastitis prevention sheets of Test Examples 1-1 to 1-3 and Test Examples 1-5 to 1-9. In contrast, it was confirmed that the condition of the nipples could not be visually observed through the sheet body attached to the nipples in the mastitis prevention sheet of Test Example 1-4.

[0115] [Test Example 2] [Test Example 2-1] A mastitis prevention sheet of Test Example 2-1 was obtained in the same manner as Test Example 1-1. In this case, the length of the long side of the sheet body of the mastitis prevention sheet was set to 120 mm, and the length of the short side was set to 70 mm. Then, of the pair of long sides of the sheet body, a belt-shaped portion was set along the second long side facing the first long side that is the boundary between the first region of the protective layer and the sheet body. In this case, the width of the belt-shaped portion in the direction in which the short side extends was set to 10 mm based on the second long side. Then, two rows of through holes were formed in the belt-shaped portion. In this case, the distance between the rows was set to 2 mm, the length of the through holes in the direction in which the long sides extend was set to 1 mm, and the distance between the through holes in the direction in which the long sides extend was set to 1 mm.

[0116] [Test Example 2-2] A mastitis prevention sheet of Test Example 2-2 was obtained in the same manner as Test Example 2-1, except that the length of the through hole in the direction in which the long side extends was set to 2 mm.

[0117] [Test Example 2-3] A mastitis prevention sheet of Test Example 2-3 was obtained in the same manner as Test Example 2-1, except that the length of the through hole in the direction in which the long side extends was set to 3 mm.

[0118] [Test Example 2-4] A mastitis prevention sheet of Test Example 2-4 was obtained in the same manner as Test Example 2-1, except that the length of the through hole in the direction in which the long side extends was set to 4 mm.

[0119] [Test Example 2-5] A mastitis prevention sheet of Test Example 2-5 was obtained in the same manner as Test Example 2-1, except that the length of the through hole in the direction in which the long side extends was set to 5 mm.

[0120] [Evaluation method] [Paste] When each mastitis prevention sheet was attached to the silicone nipple of a dairy cow's feeding bottle, whether or not the mastitis prevention sheet broke was evaluated using the following three-point scale.

[0121] No tears occurred in the mastitis prevention sheet between the through holes in the direction of the long side. △: Tears were observed in the mastitis prevention sheet in some areas between the through-holes in the direction in which the long side extends, but no widening of the through-holes was observed. × When the mastitis prevention sheet was attached to the silicone nipple, the through holes expanded in the direction of the short side, causing part of the mastitis prevention sheet to tear.

[0122] [leak] After filling a milk bottle with water, each mastitis prevention sheet was attached to a silicone nipple that would discharge water from the nipple opening over time. Then, 10 minutes after the mastitis prevention sheet was attached, whether water was leaking from the mastitis prevention sheet was evaluated using the following two-point scale.

[0123] ○ No water was leaking from the holes in the mastitis prevention sheet. △ Water was leaking from the holes in the mastitis prevention sheet.

[0124] [Emission] After pouring water into a milk bottle for dairy cows, each mastitis prevention sheet was attached to a silicone nipple that discharged water from the nipple opening over time. Next, 10 minutes after the mastitis prevention sheet was attached, the silicone nipple was squeezed with the right hand. Whether water could be discharged from the through hole of the mastitis prevention sheet was evaluated on the following two-point scale.

[0125] Water drained out of the holes without resistance. △: Although it is possible for water to be discharged through the through holes, the resistance to the water's discharge from the through holes is high, making it difficult for the water to be discharged, or, although it is possible for water to be discharged through the through holes, parts of the mastitis prevention sheet are torn as the water is discharged.

[0126] [Evaluation Results] The evaluation results for application, leakage, and discharge of the mastitis prevention sheets of each test example are shown in Figure 15.

[0127] As shown in Figure 15, the evaluation results for application of the mastitis prevention sheets were "○" for the mastitis prevention sheets of Test Example 2-1 to Test Example 2-3, "△" for the mastitis prevention sheet of Test Example 2-4, and "×" for the mastitis prevention sheet of Test Example 2-5. Note that, since the evaluation result for application of the mastitis prevention sheet of Test Example 2-5 was "×", the mastitis prevention sheet of Test Example 2-5 was not evaluated for leakage and discharge.

[0128] The evaluation results for water leakage were found to be "○" for the mastitis prevention sheets of Test Examples 2-1 to 2-4.

[0129] The evaluation results for water discharge were "○" for the mastitis prevention sheets of Test Example 2-2 and Test Example 2-3. In contrast, the mastitis prevention sheet of Test Example 2-1 had high resistance when water was discharged from the through holes, which made it difficult for water to be discharged, and the evaluation result was "△". Furthermore, the mastitis prevention sheet of Test Example 2-4 was evaluated as "△" because parts of the mastitis prevention sheet were torn as water was discharged.

[0130] From these results, it was confirmed that application, leakage, and discharge were all within the acceptable range in Test Examples 2-1 to 2-4, and the evaluation results of Test Examples 2-1 to 2-4 were "○". On the other hand, since the evaluation result of application in Test Example 2-5 was "×", the evaluation result of Test Example 2-5 itself was also confirmed to be "×". Therefore, it can be said that the length of the through hole is preferably 1 mm or more and 4 mm or less, and more preferably 2 mm or more and 3 mm or less.

[0131] As described above, according to one embodiment of the method of using a mastitis prevention sheet, the mastitis prevention sheet, and the method of manufacturing a mastitis prevention sheet, the effects described below can be obtained. (1) The mastitis prevention sheet 10 is attached to the nipple N so as to have a cylindrical shape surrounding the nipple N. This makes it difficult for milk M secreted from the nipple orifice NA to spread between the adhesive surface 12S and the nipple N. Also, because the first portion 12S1 of the adhesive surface 12S adheres to the second portion 12S2 at a position away from the nipple orifice NA, milk M secreted from the nipple orifice NA is unlikely to remain between the adhesive surface 12S and the nipple orifice NA. Therefore, the adhesive layer 12 is unlikely to peel off from the nipple N, and as a result, the sheet body 10B is unlikely to peel off from the nipple N.

[0132] (2) The adhesive portion formed by adhering the fourth portion 12S4 to the third portion 12S3 of the adhesive surface 12S is less susceptible to the spread of milk M secreted from the nipple orifice NA, making it difficult for the adhesive layer 12 to peel off from the nipple N.

[0133] (3) Since the through hole 10H is located at the tubular end 10TE of the mastitis prevention sheet 10, milk M secreted from the nipple N can be discharged from the through hole 10H at the tubular end 10TE to outside the space surrounded by the sheet body 10B.

[0134] (4) When milk M is discharged through the through-hole 10H, the sheet body 10B is even less likely to peel off from the nipple N than when milk M secreted from the nipple opening NA remains within the space surrounded by the sheet body 10B.

[0135] (5) The adhesive layer 12 contains 2% by mass or more of chitosan, so that the mastitis prevention sheet 10 can have an antibacterial effect. In addition, since the adhesion strength when the first portion 12S1 of the adhesive surface 12S is adhered to the second portion 12S2 is 2N / 25mm or more, the mastitis prevention sheet 10 can be attached to the nipple N by the adhesion part formed by the adhesion between the third portion 12S3 and the fourth portion 12S4. In addition, since the adhesion strength between the first portion 12S1 and the second portion 12S2 of the adhesive surface 12S is 10N / 25mm or less, when the tube end 10TE of the mastitis prevention sheet 10 is blocked below the nipple orifice NA, it is possible to form a space in which the milk M secreted from the nipple orifice NA can accumulate.

[0136] (6) When the mastitis prevention sheet 10 is attached to the nipple N, the through hole 10H can be positioned below the nipple orifice NA, so that milk secreted from the nipple orifice NA can be discharged from the space surrounded by the sheet body 10B through the through hole 10H.

[0137] (7) When the length of the through hole 10H is 1 mm or more and 4 mm or less, it is possible to increase the reliability of the mastitis prevention sheet 10 adhering to the nipple N and also to increase the reliability of milk M being discharged through the through hole 10H.

[0138] (8) In the case where the total light transmittance of the sheet body 10B is 30% or more, when the sheet body 10B is attached to the nipple N, it is possible to observe the nipple N through the sheet body 10B.

[0139] The above-described embodiment can be modified as follows. [How to use the mastitis prevention sheet] The mastitis prevention sheet 10 may be attached to the nipple N by the following method. First, as shown in FIG. 6, a part of the mastitis prevention sheet 10 is positioned on the nipple N. Next, the protective layer 13 is peeled off from the base layer 11 while wrapping the mastitis prevention sheet 10 around the nipple N. The surface of the base layer 11 that contacts the adhesive layer 12 and from which the protective layer 13 has been peeled off is the adhered surface. A first portion of the adhesive surface 12S of the adhesive layer 12 is brought into close contact with a first portion of the adhered surface of the base layer 11, whereby the sheet body 10B can be attached to the nipple N in a state in which the sheet body 10B has a tubular shape that surrounds the nipple N.

[0140] According to the above-mentioned method, the following effects can be obtained. (9) The adhesive portion formed by adhering the first portion of the adhesive surface 12S to the first portion of the adhered surface is less susceptible to the spread of milk M secreted from the nipple orifice, and therefore the adhesive layer 12 is less likely to peel off from the nipple N.

[0141] [Through hole] The mastitis prevention sheet 10 does not have to have through holes 10H. Even in this case, if the mastitis prevention sheet 10 satisfies conditions 1 and 2, the effect equivalent to (1) above can be obtained.

[0142] The mastitis prevention sheet 10 may have through holes extending along the short sides. Even in this case, it is possible to discharge milk M through the through holes by squeezing the teats N of the dairy cow C together with the mastitis prevention sheet 10.

[0143] [Total light transmittance] The total light transmittance may be 30% or more in only a part of the sheet body 10B. That is, the sheet body 10B may have a transmitting portion that is a part of the sheet body 10B and has a total light transmittance of 30% or more. In this case, the following effects can be obtained.

[0144] (10) Through the transparent portion, it is possible to visually observe the state of the nipple N or the state of the space formed below the nipple N.

[0145] The total light transmittance of the sheet body 10B may be less than 30%. Even in this case, the mastitis prevention sheet 10 can achieve the effect equivalent to that of (1) above by satisfying conditions 1 and 2. [Explanation of symbols]

[0146] 10. Mastitis prevention sheet 10B…Seat body 10H...Through hole 11...Base material layer 12…adhesive layer 12S…adhesive surface 12S1…Part 1 12S2…Second part 12S3…3rd part 12S4…4th part 13...Protective layer 14…Release layer

Claims

1. A method for using a mastitis prevention sheet for livestock having an antibacterial effect, the method comprising: a base layer; and an adhesive layer that contains chitosan and is supported on the base layer, the method comprising: In the adhesive layer, a surface opposite to a surface facing the base layer is an adhesive surface, Attaching the mastitis prevention sheet to the nipple so that the mastitis prevention sheet has a tubular shape surrounding the nipple; and and adhering a first portion of the adhesive surface to a second portion of the adhesive surface at a position away from a nipple opening of the nipple so as to close a tubular end of the mastitis prevention sheet. How to use mastitis prevention sheets.

2. Attaching the mastitis prevention sheet to the nipple includes attaching the mastitis prevention sheet to the nipple such that the mastitis prevention sheet has a tubular shape surrounding the nipple by adhering the third portion of the adhesive surface to the fourth portion of the adhesive surface. A method for using the mastitis prevention sheet according to claim 1.

3. In the base material layer, a surface opposite to a surface facing the adhesive layer is an adhesive surface, Attaching the mastitis prevention sheet to the nipple includes attaching the mastitis prevention sheet to the nipple so that the mastitis prevention sheet has a tubular shape surrounding the nipple by closely adhering the third portion of the adhesive surface to the first portion of the adhesive surface of the base layer. A method for using the mastitis prevention sheet according to claim 1.

4. The mastitis prevention sheet has a through hole penetrating the mastitis prevention sheet in a thickness direction of the mastitis prevention sheet, The step of attaching the mastitis prevention sheet includes attaching the mastitis prevention sheet to the nipple so that the through-hole is positioned at the tubular end of the mastitis prevention sheet. A method for using the mastitis prevention sheet according to any one of claims 1 to 3.

5. The method further includes discharging milk from the through-holes located at the tubular end of the mastitis prevention sheet. A method for using the mastitis prevention sheet according to claim 4.

6. A base layer; A mastitis prevention sheet having an antibacterial effect, comprising: an adhesive layer supported on the base layer, the adhesive layer containing 2% by mass or more of chitosan, In the adhesive layer, a surface opposite to a surface facing the base layer is an adhesive surface, The adhesive strength between the first portion of the adhesive surface and the second portion of the adhesive surface is 2 N / 25 mm or more and 10 N / 25 mm or less. Mastitis prevention sheet.

7. When viewed from a perspective opposite to the plane on which the mastitis prevention sheet spreads, The mastitis prevention sheet is A belt-shaped portion along the outer edge of the mastitis prevention sheet; a through hole that penetrates the mastitis prevention sheet along the thickness direction of the mastitis prevention sheet and is located in the belt-shaped portion, the through hole having a shape that extends along the outer edge of the mastitis prevention sheet. The mastitis prevention sheet according to claim 6.

8. When viewed from a viewpoint opposite to the plane on which the mastitis prevention sheet is spread, the length of the through hole is 1 mm or more and 4 mm or less. The mastitis prevention sheet according to claim 7.

9. The adhesive layer is in contact with the base layer, The total light transmittance in at least a part of the sheet body composed of the adhesive layer and the base layer is 30% or more. A mastitis prevention sheet according to any one of claims 6 to 8.

10. A method for producing a mastitis prevention sheet for livestock having an antibacterial effect, comprising: a base layer; and an adhesive layer containing chitosan and supported on the base layer, forming the substrate layer; forming the adhesive layer containing 2% by mass or more of the chitosan, and having an adhesion strength of 2 N / 25 mm or more and 10 N / 25 mm or less between a first portion of the adhesive surface, which is the surface opposite to the surface facing the base layer, and a second portion of the adhesive surface; and bonding the adhesive layer to the base layer; Forming the adhesive layer includes using an acidic aqueous solution containing the chitosan. A method for manufacturing mastitis prevention sheets.

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