Bicarbonate bath agent and method for producing the same

Abstract

To provide a bicarbonate bath agent that does not use polyethylene glycol, and a method for producing the agent.SOLUTION: In producing a bicarbonate bath agent that consists of tablets formed by compression-molding a material containing bicarbonate (sodium hydrogencarbonate or potassium hydrogencarbonate), organic acid (citric acid, succinic acid, fumaric acid, malic acid), and a granulation promotor, polyoxyethylene-polyoxypropylene glycol, polyethylene glycol monostearate, polyvinyl pyrrolidone, polyacrylic acid, polyethyleneimine, polyvinyl alcohol, carboxymethyl cellulose, carboxyvinyl polymer, cationized polymer, styrene polymer emulsion, polyphosphoric acid, pyrophosphoric acid, alginic acid, methyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, cellulose acetate phthalate, crystalline cellulose or the like is used as the granulation promotor.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to a bicarbonate bath additive that does not use PEG (polyethylene glycol) and a method for producing the same. [Background technology]

[0002] In recent years, health concerns have become extremely high, and care is taken to ensure that anything that comes into contact with the skin does not contain unnecessary chemicals.

[0003] For example, tap water taken from a water source is disinfected with chlorine using sodium hypochlorite. The water undergoes primary chlorination at a water purification plant to disinfect and remove organic compounds, and a secondary chlorine treatment is added just before the water is supplied to homes to maintain residual chlorine and prevent diseases caused by pathogens.

[0004] However, the chlorine used to disinfect the water sources mentioned above has the property of destroying the proteins in skin and hair, so if chlorine reacts with the proteins in skin and hair, it can cause various skin problems, as well as roughening and aging the skin and hair. Furthermore, chlorine is said to generate trihalomethanes, which can cause cancer.

[0005] The effects of chlorine are felt when washing hands and faces, but in particular, chlorine must be removed when bathing, since the bather is in contact with tap water containing chlorine for a long time. Therefore, the inventor of the present application has invented a bath additive that can effectively remove chlorine from tap water (Patent Document 1 below). This bath additive is a mixed compression molded tablet of a mixture A in which bicarbonate is mixed or granulated in the presence of polyethylene glycol, and a mixture B consisting of a mixture or granulation of an organic acid and polyethylene glycol in an amount of 1 / 100 to 2 / 3 of the mixture A, and at least one selected from alkanesulfonates having 6 to 18 carbon atoms, olefinsulfonates, and sucrose fatty acid esters, at least one of the mixtures A and B contains a chlorine neutralizing compound selected from L-ascorbate, thiosulfate, sulfite, tea catechin, and erythorbate. [Prior art documents] [Patent documents]

[0006] [Patent Document 1] Patent No. 6525945 [Non-patent literature]

[0007] [Non-Patent Document 1] Nobuhiro Maruyama and Shigeji Koboshi, "No. 29 Development of bicarbonate ion-citric acid bath additives and measures to prevent illness", Journal of the Japanese Society of Balneology, Climatology, and Physical Medicine, Vol. 78, No. 1 Summary of the Invention [Problem to be solved by the invention]

[0008] The bath additives described above can effectively remove chlorine from tap water, but polyethylene glycol is usually used in bath additives as a water-soluble polymeric material (hereinafter referred to as a granulation promoter) to improve moldability and solubility of the bath additive in hot water. Since solvents such as ethylene oxide, a carcinogenic substance, and 1,4-dioxane, which is suspected to be carcinogenic, are used in the manufacturing process of this polyethylene glycol, there are concerns that it may be contaminated by these solvents. In addition, since polyethylene glycol remains in the body for a long time, there are concerns that it may cause allergies.

[0009] In light of this, there is a demand for a material to replace polyethylene glycol as a granulation promoter for bath additives.

[0010] The present invention has been made in consideration of the above problems, and its main object is to provide a bicarbonate bath additive that does not use polyethylene glycol and a method for producing the same. [Means for solving the problem]

[0011] One aspect of the present invention is a bicarbonate bath additive comprising a tablet obtained by compressing and molding a material containing a bicarbonate, an organic acid, and a chlorine-neutralizing compound using a granulation promoter, the bicarbonate being sodium hydrogen carbonate or potassium hydrogen carbonate, the organic acid being at least one selected from citric acid, succinic acid, fumaric acid, and malic acid, the chlorine-neutralizing compound being at least one selected from L-ascorbate, thiosulfate, sulfite, tea catechin, and erythorbate, and the granulation promoter being polyoxyethylene polyoxypropylene glycol, polyethylene glycol monostearate, polyvinylpyrrolidone, polyacrylic acid and salts thereof, polyethyleneimine, polyvinyl alcohol, carboxymethylcellulose and salts thereof, carboxyvinylpoly The material is characterized in that it is at least one selected from the group consisting of cellulose acetate, cellulose ester, cationic polymer, styrene polymer emulsion, polyphosphoric acid and its salts, pyrophosphoric acid and its salts, methylcellulose, hydroxyethylcellulose and its salts, hydroxypropylcellulose, cellulose acetate phthalate, crystalline cellulose, propylene glycol alginate, starch, oxidized starch, esterified starch, etherified starch, cationic starch, glue, agar, gelatin, collagen protein, liquid paraffin, casein, pectin, alginic acid and its salts, carrageenan, furcellan, tamarind gum, gum arabic, guar gum, xanthan gum, tragacanth gum, locust bean gum, karaya gum, quince seed, dextrin, and dextran.

[0012] Another aspect of the present invention is a method for producing a bicarbonate bath additive comprising a tablet containing a bicarbonate, an organic acid, a chlorine neutralizing compound, and a granulation promoter, wherein the bicarbonate is sodium hydrogen carbonate or potassium hydrogen carbonate, the organic acid is at least one selected from citric acid, succinic acid, fumaric acid, and malic acid, the chlorine neutralizing compound is at least one selected from L-ascorbate, thiosulfate, sulfite, tea catechin, and erythorbate, and the granulation promoter is polyoxyethylene polyoxypropylene glycol, polyethylene glycol monostearate, polyvinylpyrrolidone, polyacrylic acid and salts thereof, polyethyleneimine, polyvinyl alcohol, carboxymethylcellulose and salts thereof, carboxyvinyl polymer, cationic polymer, styrene polymer emulsion, polyphosphoric acid and salts thereof, pyrophosphoric acid, and its salts, methylcellulose, hydroxyethylcellulose and its salts, hydroxypropylcellulose, cellulose acetate phthalate, crystalline cellulose, propylene glycol alginate, starch, oxidized starch, esterified starch, etherified starch, cationic starch, glue, agar, gelatin, collagen protein, liquid paraffin, casein, pectin, alginic acid and its salts, carrageenan, furcellaran, tamarind gum, gum arabic, guar gum, xanthan gum, tragacanth gum, locust bean gum, karaya gum, quince seed, dextrin, and dextran, and the bicarbonate is coated with the granulation promoter to prepare a granulated product, and the granulated product is mixed with a mixture of the organic acid, the chlorine neutralizing compound, and the granulation promoter, and then compressed and molded to prepare the tablet.

[0013] Another aspect of the present invention is a method for producing a bicarbonate bath additive comprising a tablet containing a bicarbonate, an organic acid, a chlorine neutralizing compound, and a granulation promoter, wherein the bicarbonate is sodium hydrogen carbonate or potassium hydrogen carbonate, the organic acid is at least one selected from citric acid, succinic acid, fumaric acid, and malic acid, the chlorine neutralizing compound is at least one selected from L-ascorbate, thiosulfate, sulfite, tea catechin, and erythorbate, and the granulation promoter is polyoxyethylene polyoxypropylene glycol, polyethylene glycol monostearate, polyvinylpyrrolidone, polyacrylic acid and salts thereof, polyethyleneimine, polyvinyl alcohol, carboxymethylcellulose and salts thereof, carboxyvinyl polymer, cationic polymer, styrene polymer emulsion, polyphosphoric acid and salts thereof, pyrophosphoric acid, and its salts, methylcellulose, hydroxyethylcellulose and its salts, hydroxypropylcellulose, cellulose acetate phthalate, crystalline cellulose, propylene glycol alginate, starch, oxidized starch, esterified starch, etherified starch, cationic starch, glue, agar, gelatin, collagen protein, liquid paraffin, casein, pectin, alginic acid and its salts, carrageenan, furcellaran, tamarind gum, gum arabic, guar gum, xanthan gum, tragacanth gum, locust bean gum, karaya gum, quince seed, dextrin, and dextran, and the method is characterized in that the organic acid is coated with the granulation promoter to prepare a granulated product, and the granulated product is mixed with a mixture of the bicarbonate, the chlorine neutralizing compound, and the granulation promoter, and then compression-molded to prepare the tablet. Effect of the Invention

[0014] According to the present invention, it is possible to provide a bicarbonate bath additive that does not use polyethylene glycol and a method for producing the same.

[0015] The reason is that when bicarbonate (sodium hydrogen carbonate or potassium hydrogen carbonate), organic acid (at least one selected from citric acid, succinic acid, fumaric acid, and malic acid), and chlorine neutralizing compound (at least one selected from L-ascorbate, thiosulfate, sulfite, tea catechin, and erythorbate) are compressed and molded using a granulation promoter, polyoxyethylene polyoxypropylene glycol, polyethylene glycol monostearate, polyvinylpyrrolidone, polyacrylic acid and its salts, polyethyleneimine, polyvinyl alcohol, carboxymethylcellulose and its salts, carboxyvinyl polymer, cationic polymer, styrene polymer emulsion, etc. are used as the granulation promoter. This is because one material selected from the group consisting of cellulose acetate, polyphosphoric acid and its salts, pyrophosphoric acid and its salts, methylcellulose, hydroxyethylcellulose and its salts, hydroxypropylcellulose, cellulose acetate phthalate, crystalline cellulose, propylene glycol alginate, starch, oxidized starch, esterified starch, etherified starch, cationic starch, glue, agar, gelatin, collagen protein, liquid paraffin, casein, pectin, alginic acid and its salts, carrageenan, furcellan, tamarind gum, gum arabic, guar gum, xanthan gum, tragacanth gum, locust bean gum, karaya gum, quince seed, dextrin, and dextran is used. [Brief description of the drawings]

[0016] [Figure 1] FIG. 1 is a schematic diagram illustrating the mechanism by which blood flow is increased by bicarbonate ions. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0017] The effect of bicarbonate ions will be explained. Generally, carbon dioxide dissolved in water exists as dissolved inorganic carbon, but this dissolved inorganic carbon exists in three forms due to bicarbonate equilibrium, and it is said that the form changes depending on the pH of the solution. It is known that the abundance ratio of the three types of dissolved inorganic carbon depending on the pH is such that in the region where the pH of the solution is weakly acidic or lower, the proportion of bicarbonate ions is low and the proportion of carbonic acid is high, in the neutral to weakly alkaline region, the proportion of bicarbonate ions is highest, and in the alkaline region, the bicarbonate ions are low and the carbonate ions are high, symmetrically.

[0018] In addition, carbon dioxide is said to migrate from the skin surface to the capillaries via an accessory organ pathway that passes through the pores and sweat glands of the skin. Since the pH range of blood coincides with the pH range in which bicarbonate ions are present at their highest concentration, the inventors of the present application focused on the possibility that much of the carbon dioxide that migrates from the skin into the blood may exert physiological activity as bicarbonate ions and have beneficial effects on the living body, and investigated the effects of bicarbonate ions on the living body (see non-patent document 1).

[0019] As a result, in vivo tests showed a significant increase in blood flow in mice compared to the control group, and a tendency for an increase in the amount of bicarbonate ions in the blood and NO production via phosphorylation of endothelial nitric oxide synthase in peripheral blood vessels was observed. Furthermore, in in vitro tests using human umbilical artery endothelial cells, the presence of neutral bicarbonate ion water promoted phosphorylation of endothelial nitric oxide synthase and increased NO production, and the reactive oxygen species scavenging activity of neutral bicarbonate ion water was significantly higher than that of the control. In addition, a double-blind randomized controlled study conducted on middle-aged men and women with subjective symptoms of chilliness showed that neutral bicarbonate ion water had the effect of increasing body temperature and improving chilliness symptoms and sleep quality.

[0020] These findings demonstrate that bicarbonate ions, when absorbed percutaneously, phosphorylate endothelial nitric oxide synthase through their direct action on the vascular endothelium, thereby promoting blood flow by increasing NO production, suggesting their usefulness in improving various clinical symptoms in the cardiovascular field associated with poor circulation.

[0021] In order to efficiently absorb bicarbonate ions, it is important that the pH of the water in which the bath additives are dissolved be in the neutral range (a pH of around 7) and that the bicarbonate ions in the water be at a high concentration. Therefore, the inventors of the present application have invented a method for producing tablets of a certain level of hardness by compression molding bicarbonate (sodium bicarbonate, potassium bicarbonate), organic acids (citric acid, succinic acid, fumaric acid, malic acid), and chlorine neutralizing compounds (L-ascorbate, thiosulfate, sulfite, tea catechin, erythorbate) in the presence of polyethylene glycol (Patent Document 1).

[0022] In the bicarbonate bath additive produced by this method, a neutralization reaction occurs vigorously and efficiently, and by continuously releasing the smallest possible carbon dioxide bubbles for a certain period of time, most of the generated carbon dioxide can be dissolved in the bath water without escaping into the air. In addition, by designing the pH to be neutral immediately after dissolution, the bicarbonate ions in the bath water become highly concentrated, and further, by making the pH neutral, the carbon dioxide that comes into contact with the skin easily becomes bicarbonate ions, which, combined with the bicarbonate ions that are naturally present, make the bicarbonate ions highly concentrated, allowing the absorption of bicarbonate ions from the skin into the blood vessels to be maximized, and the blood flow can be promoted by increasing NO production. Furthermore, the chlorine contained in tap water can be effectively removed by the chlorine neutralizing compound, preventing the destruction of proteins in the skin and hair.

[0023] However, this bath additive uses polyethylene glycol as a granulation promoter, and polyethylene glycol may be contaminated with ethylene oxide, a carcinogen, or 1,4-dioxane, which is suspected to be carcinogenic. In addition, polyethylene glycol may cause allergies because it remains in the body for a long time.

[0024] Therefore, the inventors of the present application conducted experiments to prepare bicarbonate bath additives using various materials that can be used as granulation promoters, and as a result, found that the following materials were effective: polyoxyethylene polyoxypropylene glycol, polyethylene glycol monostearate, polyvinylpyrrolidone, polyacrylic acid and its salts, polyethyleneimine, polyvinyl alcohol, carboxymethylcellulose and its salts, carboxyvinyl polymer, cationic polymer, styrene polymer emulsion, polyphosphoric acid and its salts, pyrophosphoric acid and its salts, methylcellulose, hydroxyethylcellulose and its salts, hydroxypropylcellulose, cellulose acetate phthalate, crystalline cellulose, The inventors have found that propylene glycol alginate, starch, oxidized starch, esterified starch, etherified starch, cationic starch, glue, agar, gelatin, collagen protein, liquid paraffin, casein, pectin, alginic acid and its salts, carrageenan, furcellaran, tamarind gum, gum arabic, guar gum, xanthan gum, tragacanth gum, locust bean gum, karaya gum, quince seed, dextrin, dextran, and the like can be used as granulation promoters in place of polyethylene glycol, and have confirmed that the use of these granulation promoters makes it possible to produce bicarbonate bath additives that can exert the effects of bicarbonate ions described above. EXAMPLES

[0025] In order to explain the above-mentioned embodiment of the present invention in more detail, a bicarbonate bath additive and a method for producing the same according to one embodiment of the present invention will be described.

[0026] FIG. 1 shows a schematic diagram of the structure of a human blood vessel, in which the dermis / subcutaneous adipose tissue 2 is located inside the epidermis 1, and the blood vessel 5 is located inside the dermis / subcutaneous adipose tissue 2. The blood vessel 5 is composed of a blood vessel wall 6 having smooth muscle 7 and vascular endothelial cells 8 on the inside of the blood vessel wall 6, and the inside of the vascular endothelial cells 8 is the inside of the blood vessel 9. When a person bathes in hot water containing dissolved bicarbonate ions, as shown in FIG. 1, the bicarbonate ions penetrate into the blood vessel 9 through sweat pores 4 and the like, phosphorylating endothelial nitric oxide synthase (eNOS) present in the vascular endothelial cells 8 (P-eNOS), which acts on L-arginine (L-Al) to generate nitric oxide (NO). The generated NO is converted to cyclic guainosine monophosphate (cGMP) by guanosine triphosphate (GTP) via guanylate cyclase enzyme (sGC). The cyclic guainosine monophosphate (cGMP) relaxes the smooth muscle 7 in the blood vessel wall 6, which results in the expansion of the blood vessel 5 and an increase in blood flow.

[0027] Therefore, by increasing the concentration of bicarbonate ions in the bath water using bicarbonate bath additives that dissolve the bicarbonate ions in the bath water to a neutral pH level, the secretion of nitric oxide into the vascular endothelium becomes more active due to the effects of the bicarbonate ions described above, and blood flow can be dramatically improved. Below, we will explain the bicarbonate bath additives that provide the effects of bicarbonate ions.

[0028] The bicarbonate bath additive of this embodiment is made by compressing and molding bicarbonate (sodium bicarbonate or potassium bicarbonate), organic acid (citric acid, succinic acid, fumaric acid, malic acid), and chlorine neutralizing compound (L-ascorbate, thiosulfate, sulfite, tea catechin, erythorbate) using a granulation promoter other than polyethylene glycol.

[0029] The bicarbonate salts, especially sodium hydrogen carbonate (sodium bicarbonate), act as foaming agents, and when dissolved in hot water together with an organic acid, they undergo a neutralization reaction to produce carbon dioxide foam, while dissociating into bicarbonate ions and hydrogen ions depending on the pH of the water in which they are dissolved, and dissolve in the water. These bicarbonate ions have the ability to clean mineral sebum dirt in pores, which is the source of so-called odor. The content of bicarbonate salts in bicarbonate bath additives is specified in relation to other ingredients. If the content is less than the specified amount, the pH value when dissolved in hot water will not be the specified value, and the amount of bicarbonate ions dissolved in hot water will be significantly reduced. On the other hand, if the content exceeds the specified amount, the foaming of carbon dioxide gas will be significantly reduced.

[0030] In addition, the organic acids, particularly citric acid, succinic acid, fumaric acid, and malic acid, neutralize bicarbonate and generate carbon dioxide gas effervescence, and when dissolved in hot water, they also have a skin cleansing effect and a skin softening effect. In particular, when citric acid is used, the neutralization reaction occurs more effectively than when other organic acids are used. The content of the organic acid is specified in relation to the other components, as described above. If the content is less than the specified amount, the amount of carbon dioxide gas effervescence during the dissolution of the tablet decreases, the amount of bicarbonate ions dissolved decreases, and the blood flow enhancement effect decreases. On the other hand, if the content exceeds the specified amount, the amount of carbon dioxide gas effervescence increases, but the diameter of the bubbles increases, making it difficult to neutralize the gas, and the amount of bicarbonate ions dissolved decreases.

[0031] The chlorine neutralizing compounds include L-ascorbic acid salts, thiosulfates, sulfites, tea catechins, erythorbic acid salts, etc. Any known ascorbic acid salts can be used without any particular restrictions. Examples of salts include sodium salts and calcium salts, with sodium salts being preferred. L-ascorbic acid is widely known as vitamin C, and when added to tap water, it can remove chlorine contained in tap water through the reactions shown in the following reaction formulas 1 and 2. Reducing agents such as sodium thiosulfate, thiosulfates, sulfites, and tea catechins can also neutralize and detoxify chlorine through a similar reaction.

[0032] [Reaction 1] C6H8O6 + NaClO → C6H6O6 + H2O + NaCl (Reaction in which vitamin C reduces and removes sodium hypochlorite, which is added for primary sterilization)

[0033] [Reaction 2] C6H8O6 + Cl2 → C6H6O6 + 2HCl (Reaction in which chlorine added to maintain chlorine is removed by vitamin C)

[0034] When ascorbic acid dissolves in tap water through the reactions shown in Reactions 1 and 2, the chlorine contained in the tap water is removed. This prevents the problems caused by residual chlorine on the skin, such as oxidation, aging, and dandruff. In addition, ascorbic acid itself has the effects of increasing skin firmness, preventing fine wrinkles, beautifying the skin, whitening, and anti-aging. As shown in Reaction 2, a small amount of hydrochloric acid is generated when chlorine is removed, but the pH of the dissolved water is buffered by the buffering effect of bicarbonate ions and organic acids, so the pH of shower water and bath water does not become acidic, and the pH of tap water remains stable.

[0035] The granulation promoter plays the role of compressing and molding materials such as bicarbonate, organic acid, and chlorine neutralizing compound to produce tablets, of making tablets more soluble in hot water, and of maximally dissolving carbon dioxide gas components as bicarbonate ions when the tablets are dissolved in hot water. The granulation promoter is polyoxyethylene polyoxypropylene glycol, polyethylene glycol monostearate, polyvinylpyrrolidone, polyacrylic acid and its salts, polyethyleneimine, polyvinyl alcohol, carboxymethylcellulose and its salts, carboxyvinyl polymer, cationic polymer, styrene polymer emulsion, polyphosphoric acid and its salts, pyrophosphoric acid and its salts, methylcellulose, hydroxyethylcellulose and its salts, hydroxypropylcellulose, cellulose acetate phthalate, crystalline cellulose, propylene alginate, ... polyoxyethylene polyoxypropylene glycol, polyoxyethylene polyoxypropylene glycol, polyoxyethylene polyoxypropylene glycol, polyoxyethylene polyoxypropylene glycol, polyoxyethylene polyoxypropylene glycol, polyoxyethylene polyoxypropylene glycol, polyoxyethylene polyoxypropylene glycol, polyoxyethylene polyoxypropylene glycol, polyoxyethylene polyoxypropylene glycol, polyoxyethylene polyoxypropylene glycol, polyoxyethylene polyoxypropylene glycol, polyoxyethylene polyoxypropylene glycol, polyoxyethylene polyoxypropylene glycol, polyoxyethylene polyoxypropylene glycol, polyoxyethylene polyoxypropylene glycol, polyoxyethylene polyoxypropylene glycol, polyoxyethylene polyoxypropylene glycol, polyoxyethylene polyoxypropylene glycol, polyoxyethylene polyoxypropylene glycol, polyoxyethylene polyoxypropylene glycol, polyoxyethylene polyoxypropylene glycol, polyoxyethylene polyoxypropylene glycol, polyoxyethylene polyoxypropylene glycol, polyoxy It is preferable to select from the group consisting of glycol esters, starch, oxidized starch, esterified starch, etherified starch, cationic starch, glue, agar, gelatin, collagen protein, liquid paraffin, casein, pectin, alginic acid and its salts, carrageenan, furcellan, tamarind gum, gum arabic, guar gum, xanthan gum, tragacanth gum, locust bean gum, karaya gum, quince seed, dextrin, and dextran, and can be appropriately selected depending on the tablet hardness, ease of compression molding, compatibility with the granulator, and the degree of carbon dioxide gas bubble generation. The content of this granulation promoter is specified in relation to the other components as described above. If the content is less than the specified amount, the diameter of the carbon dioxide gas bubbles will be large and the foaming time will be shortened, making it difficult to increase the amount of carbon dioxide gas components dissolved in hot water. On the other hand, if the content exceeds the specified amount, the amount of bubbles generated will be suppressed, and similarly, the amount of carbon dioxide gas components dissolved in hot water will be reduced.

[0036] Next, a method for producing a bicarbonate bath additive using these ingredients will be described.

[0037] Methods for mixing the bicarbonate, organic acid, and granulation aid that are the basic ingredients of bicarbonate bath additives include: (1) coating the bicarbonate with a granulation aid to create a granule, and then mixing the granule with a mixture of the organic acid and granulation aid; (2) coating the organic acid with a granulation aid to create a granule, and then mixing the granule with a mixture of the bicarbonate and granulation aid; and (3) coating the bicarbonate with a granulation aid to create a granule and coating the organic acid with a granulation aid to create a granule, and then mixing the granules.

[0038] Methods for adding a chlorine neutralizing compound to a basic component include (A) adding the chlorine neutralizing compound when mixing the granulated material with a mixture or when mixing two granulated materials together, and (B) adding the chlorine neutralizing compound when preparing the granulated material.

[0039] Either method can be used to produce a bicarbonate bath agent that exerts the effect of bicarbonate ions, but as for the method of mixing the basic components, method (1) can foam micro-sized bubbles for a long time, maximize the amount of carbon dioxide gas dissolved in the hot water, and greatly reduce the number of steps. As for the method of adding the chlorine neutralizing compound, method (A) can utilize the existing manufacturing method for the basic components and simplify the steps. Therefore, as the method of producing the bicarbonate bath agent of this embodiment, a combination of methods (1) and (A) is preferable, that is, a method in which the bicarbonate is coated with a granulation promoter to produce a granule, and the chlorine neutralizing compound is added to the mixture of the organic acid and the granulation promoter and mixed with the granule. The following explanation will be based on this method.

[0040] First, the bicarbonate is coated with a granulation promoter to prepare a granulated product. When the bicarbonate is granulated in a fluidized bed to obtain a granulated product, a mechanical fluidized bed granulator that does not substantially use air for stirring can be used to significantly increase the hardness of the tablet. In a mechanical fluidized bed granulator, air is not used for stirring, and the powder is fluidized using mechanical blades such as a propeller, so that moisture brought in from humid air during granulation is not absorbed during granulation, and it is also possible to apply a vacuum with a vacuum pump during granulation. As a result, granulation can be performed with a reduced amount of granulation promoter, which can reduce the diameter of the foaming bubbles while making the neutralization reaction more active, and is preferably used because it can produce tablets with high hardness.

[0041] A mechanical fluidized bed granulator that does not substantially use air for agitation is a mixer that has a plough-like shovel inside a horizontal drum to generate centrifugal diffusion and vortex flow effects, resulting in three-dimensional fluidization. For example, models manufactured by Deutsche Loedige AG or Matsuzaka Giken Co., Ltd. are sold on the market.

[0042] It is more preferable that the present granulator is equipped with a vacuum pump for reducing the pressure. That is, by reducing the pressure during cooling and operating so as to remove as much moisture as possible, the effect of the present invention can be improved. Furthermore, it is preferable that the present granulator is equipped with a chopper for preventing the granulated granules from becoming coarse particles during cooling. That is, by operating the chopper during cooling to regulate the size, the effect of reducing the diameter of the carbon dioxide gas bubbles of the present invention to micro-size can be achieved.

[0043] Next, a mixture of organic acid and granulation promoter is prepared. In this case, the weight ratio of the organic acid to the granulated bicarbonate salt or the mixture of organic acid and granulation promoter, and the weight ratio of the granulation promoter to the organic acid can be appropriately set according to the material used as the granulation promoter. In addition, when the mixture of organic acid and chlorine neutralizing compound is not granulated, the effect of the present invention can be obtained without adding a granulation promoter, but it is preferable to add a granulation promoter to improve tableting.

[0044] Next, add chlorine neutralizing compound to the mixture of organic acid and granulation promoter. The amount of chlorine neutralizing compound is preferably about 0.005g per 15g tablet. If it is less than 0.005g, the chlorine removal ability may decrease, and if it exceeds 1.0g, it is not only more difficult to solidify the tablet, but also disadvantageous in terms of cost.

[0045] Next, the mixture (organic acid, chlorine neutralizing compound, and granulation promoter) is mixed with the granulated material (bicarbonate and granulation promoter) and compressed to produce tablets. A known compression molding machine can be used for the compression molding to produce tablets, but for example, a hydraulic press, a single punch tablet press, a rotary tablet press, a briquetting machine, etc. can also be used.

[0046] The size of the punch used in the tablet press or the like is preferably 10 mm or more in diameter if the punch is circular, and preferably 10 mm or more in diameter if the punch is triangular or rectangular, when converted into a circular punch. The same applies to the thickness of the punch. When making a circular tablet, the diameter of the tablet is preferably 10 mm or more, and the thickness is also preferably 10 mm or more. When making a triangular or rectangular tablet, the diameter and thickness are each preferably 10 mm or more when converted into a circular tablet. The tablet does not necessarily have to be circular with a flat surface, and there is no restriction on the shape as long as it is a solid object of 10 mm or more, whether it is elliptical, tablet, or spherical.

[0047] In addition, during compression molding, the tablet hardness (breaking strength and Vickers hardness) must be at or above a specified value. The higher the hardness, the more effectively carbon dioxide gas is generated in the tablet, and the more efficiently the carbon dioxide gas dissolves in the water, resulting in finer bubbles and more favorable results. The diametric breaking strength (kgf) can be measured using the New Speed ​​Checker TS75NL digital tablet hardness tester manufactured by Okada Seiko Co., Ltd. The Vickers hardness (Hv, kgf / mm 2 ) can be measured using a micro Vickers hardness tester, Mitutoyo HM-221, which is a type of hardness tester.

[0048] The above is the basic composition and manufacturing method of bicarbonate bath additives, but surfactants such as sodium alkanesulfonate and sodium olefinsulfonate having 6 to 18 carbon atoms and sucrose fatty acid esters may be added to the bicarbonate bath additives. In addition, compounds that are preferably used include sodium lauryl sulfate, sodium lauroyl sarcosinate, sodium myristoyl methylalanine, sodium lauryl sulfonate, sodium n-(normal)octanesulfonate, sodium tetradecenesulfonate, a mixture of sodium alkanesulfonates having 14 to 18 carbon atoms, sucrose laurate, sucrose myristate, and sucrose palmitate. Among these, sodium n-(normal)octanesulfonate and sodium n-heptanesulfonate are particularly preferred.

[0049] In addition, anhydrides such as anhydrous sodium carbonate, anhydrous potassium carbonate, anhydrous calcium carbonate, and anhydrous magnesium carbonate may be added to the bicarbonate bath agent. By adding an anhydride, the bubble size of the carbon dioxide gas can be made optimally small while the foaming amount can be made larger and last for a long time, and the above effect can be exhibited significantly when anhydrous sodium carbonate is added as the anhydride. This anhydride can be added at any step before compression molding, such as the step of preparing a granulated product or the step of mixing the granulated product with a mixture, but it is preferable to add the anhydride at the stage of mixing the mixture of an organic acid, a chlorine neutralizing compound, and a granulation promoter with the granulated product of bicarbonate, and it is particularly preferable to cool the granulated product, add the organic acid, the chlorine neutralizing compound, the granulation promoter, and the anhydride at the same time, mix them, and immediately tablet them. The weight ratio of the anhydride to the bicarbonate is preferably 1 / 100 to 1 / 10, and particularly preferably 1 / 50 to 1 / 10. If the amount of anhydride is too large, the amount of foam produced will be small, while if the amount is too small, carbon dioxide gas will be generated in the water, which is undesirable. In addition, by specifying the amount of organic acid and the amount of anhydride relative to the bicarbonate granules to produce tablets of a certain size and hardness, a neutralization reaction occurs in the tablet, and the aqueous solution in which the tablet is dissolved can be made neutral to weakly alkaline.

[0050] In addition, the bicarbonate bath agent can be added with a lubricant for tableting, and it is preferable to add an organic acid, a chlorine neutralizing compound, and an anhydride to the bicarbonate granules, add a lubricant, mix, and compress to obtain tablets. In addition, the bicarbonate bath agent can be used with a release agent for tableting. As the release agent, sucrose, magnesium stearate, etc. are generally used, but magnesium stearate is the most preferable because it can be compressed stably, continuously, and at high speed to produce tablets. In addition, other ingredients can be mixed with the bicarbonate bath agent as necessary. Examples of other ingredients include health ingredients such as hyaluronic acid, fragrances, colorants, surfactants, etc.

[0051] The present invention is not limited to the above-described embodiment, and the configuration can be modified as appropriate without departing from the spirit of the present invention.

[0052] For example, in the above examples, a method was described in which a granulated material was prepared by coating a bicarbonate with a granulation accelerator, and then a mixture of an organic acid, a chlorine neutralizing compound, and the granulation accelerator was mixed. However, a method in which a granulated material was prepared by coating an organic acid with a granulation accelerator, and then a mixture of a bicarbonate, a chlorine neutralizing compound, and the granulated material was mixed with the mixture of the bicarbonate, the chlorine neutralizing compound, and the granulation accelerator can also be used. [Industrial Applicability]

[0053] INDUSTRIAL APPLICABILITY The present invention is applicable to bicarbonate bath additives and methods for producing the same, and in particular to bicarbonate bath additives that do not use PEG (polyethylene glycol) and methods for producing the same. [Explanation of symbols]

[0054] 1 epidermis 2 Dermis / subcutaneous adipose tissue 3 Pores 4. Sweat pores 5 blood vessels 6 Blood vessel wall 7 Smooth Muscle 8 Vascular endothelial cells 9 Intravascular

Claims

1. A bicarbonate bath agent comprising a tablet obtained by compressing a material containing a bicarbonate salt, an organic acid, and a chlorine neutralizing compound using a granulation promoter, the bicarbonate is sodium bicarbonate or potassium bicarbonate; The organic acid is at least one selected from citric acid, succinic acid, fumaric acid, and malic acid; the chlorine-neutralizing compound is at least one selected from L-ascorbate, thiosulfate, sulfite, tea catechin, and erythorbate; The granulation promoter is at least one selected from polyoxyethylene polyoxypropylene glycol, polyethylene glycol monostearate, polyvinylpyrrolidone, polyacrylic acid and its salts, polyethyleneimine, polyvinyl alcohol, carboxymethylcellulose and its salts, carboxyvinyl polymer, cationic polymer, styrene polymer emulsion, polyphosphoric acid and its salts, pyrophosphoric acid and its salts, methylcellulose, hydroxyethylcellulose and its salts, hydroxypropylcellulose, cellulose acetate phthalate, crystalline cellulose, propylene glycol alginate, starch, oxidized starch, esterified starch, etherified starch, cationic starch, glue, agar, gelatin, collagen protein, liquid paraffin, casein, pectin, alginic acid and its salts, carrageenan, furcellan, tamarind gum, gum arabic, guar gum, xanthan gum, tragacanth gum, locust bean gum, karaya gum, quince seed, dextrin, and dextran; A bicarbonate bath additive characterized by:

2. A method for producing a bicarbonate bath agent comprising a tablet containing a bicarbonate salt, an organic acid, a chlorine neutralizing compound, and a granulation promoter, the bicarbonate is sodium bicarbonate or potassium bicarbonate; The organic acid is at least one selected from citric acid, succinic acid, fumaric acid, and malic acid; the chlorine-neutralizing compound is at least one selected from L-ascorbate, thiosulfate, sulfite, tea catechin, and erythorbate; the granulation promoter is at least one selected from polyoxyethylene polyoxypropylene glycol, polyethylene glycol monostearate, polyvinylpyrrolidone, polyacrylic acid and its salts, polyethyleneimine, polyvinyl alcohol, carboxymethylcellulose and its salts, carboxyvinyl polymer, cationic polymer, styrene polymer emulsion, polyphosphoric acid and its salts, pyrophosphoric acid and its salts, methylcellulose, hydroxyethylcellulose and its salts, hydroxypropylcellulose, cellulose acetate phthalate, crystalline cellulose, propylene glycol alginate, starch, oxidized starch, esterified starch, etherified starch, cationic starch, glue, agar, gelatin, collagen protein, liquid paraffin, casein, pectin, alginic acid and its salts, carrageenan, furcellan, tamarind gum, gum arabic, guar gum, xanthan gum, tragacanth gum, locust bean gum, karaya gum, quince seed, dextrin, and dextran; The bicarbonate is coated with the granulation promoter to prepare a granule, and the granule is mixed with a mixture of the organic acid, the chlorine neutralizing compound, and the granulation promoter, and then compressed to prepare the tablet. A method for producing a bicarbonate bath additive comprising the steps of:

3. A method for producing a bicarbonate bath agent comprising a tablet containing a bicarbonate salt, an organic acid, a chlorine neutralizing compound, and a granulation promoter, the bicarbonate is sodium bicarbonate or potassium bicarbonate; The organic acid is at least one selected from citric acid, succinic acid, fumaric acid, and malic acid; the chlorine-neutralizing compound is at least one selected from L-ascorbate, thiosulfate, sulfite, tea catechin, and erythorbate; the granulation promoter is at least one selected from polyoxyethylene polyoxypropylene glycol, polyethylene glycol monostearate, polyvinylpyrrolidone, polyacrylic acid and its salts, polyethyleneimine, polyvinyl alcohol, carboxymethylcellulose and its salts, carboxyvinyl polymer, cationic polymer, styrene polymer emulsion, polyphosphoric acid and its salts, pyrophosphoric acid and its salts, methylcellulose, hydroxyethylcellulose and its salts, hydroxypropylcellulose, cellulose acetate phthalate, crystalline cellulose, propylene glycol alginate, starch, oxidized starch, esterified starch, etherified starch, cationic starch, glue, agar, gelatin, collagen protein, liquid paraffin, casein, pectin, alginic acid and its salts, carrageenan, furcellan, tamarind gum, gum arabic, guar gum, xanthan gum, tragacanth gum, locust bean gum, karaya gum, quince seed, dextrin, and dextran; The organic acid is coated with the granulation promoter to prepare a granulation product, and the granulation product is mixed with a mixture of the bicarbonate, the chlorine neutralizing compound, and the granulation promoter, and then compressed to prepare the tablet. A method for producing a bicarbonate bath additive comprising the steps of:

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