Topical composition

Abstract

To provide a topical composition that ensures formulation stability while offering an excellent feeling upon use on the skin, even when using (A) at least one selected from the group consisting of terpenes and their derivatives, ethanol and glycerin as a component.SOLUTION: A topical composition is prepared, comprising: (A) at least one selected from the group consisting of terpenes and their derivatives, ethanol and glycerin; and (B) a surfactant that is a fatty acid and / or its derivative and does not structurally include a polyoxyethylene structure or a hydrogenated site; where the composition is substantially free of surfactants other than the surfactant (B).SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to a topical composition. [Background technology]

[0002] In external use compositions such as cosmetics, depending on the combination of ingredients, the stability of physical properties may be impaired due to the influence of coexisting ingredients.

[0003] Among the required physical property stability, the durability of the composition when applied to the skin has a large impact on the feeling of use of the cosmetic. Generally, a cosmetic user takes a cosmetic in his / her hands, applies it to the skin, and spreads it, sensing stickiness, moistness, smoothness, skin compatibility, etc. as a feeling of use along with changes in the cosmetic state.

[0004] If the durability of the composition is impaired due to the influence of coexisting ingredients, the cosmetic will lose its shape retention when it is picked up or during storage, resulting in a poor usability of the cosmetic.

[0005] The feel of cosmetics when used is currently evaluated by sensory evaluation tests, but objective evaluation methods are also being developed.

[0006] For example, in Patent Document 1, a parallel plate type viscoelasticity measuring device is used to measure the storage modulus and loss modulus of an external skin preparation at each frequency, and the feel of the cosmetic is evaluated. [Prior art documents] [Patent documents]

[0007] [Patent Document 1] JP 2007-147342 A Summary of the Invention [Problem to be solved by the invention]

[0008] (A) At least one selected from the group consisting of terpene and its derivatives, ethanol, and glycerin is a component that is frequently used in external compositions such as cosmetics. However, a new problem has been discovered in that the durability of the composition is impaired when used in combination with a specific surfactant.

[0009] Regarding the above component (A), there has been insufficient research into the problems that arise when it is used in combination with a specific surfactant, and into the search for other components that do not cause such problems and provide a better feel when used. [Means for solving the problem]

[0010] As a result of intensive research into the above problems, the present inventors discovered that the above problems could be solved by adding a specific surfactant to the above component (A), and thus completed the present invention.

[0011] That is, the present invention provides the topical compositions described below. Section 1. (A) at least one selected from the group consisting of terpene and its derivatives, ethanol, and glycerin; and (B) A surfactant which is a fatty acid and / or a derivative thereof and does not contain a polyoxyethylene structure or a hydrogenation site in its structure. and is substantially free of any surfactants other than component (B).

[0012] Section 2. Item 2. The composition for external use according to Item 1, further comprising (C) arginine and / or lactic acid.

[0013] Section 3. Item 3. The composition for external use according to item 1 or 2, wherein the component (B) is at least one selected from the group consisting of palmitic acid, stearic acid, soybean lecithin, polyglyceryl stearate, and sorbitan trioleate.

[0014] Furthermore, the present invention relates to the following method. Section 4. (A) a composition for external use containing at least one selected from the group consisting of terpene and its derivatives, ethanol, and glycerin, A method for imparting a skin irritation reducing effect to the topical composition, characterized in that the composition contains (B) a surfactant which is a fatty acid and / or a derivative thereof and does not contain a polyoxyethylene structure or a hydrogenation site in its structure, and the composition is substantially free of any surfactants other than the component (B). Effect of the Invention

[0015] According to the present invention, even when the above-mentioned (A) component is used, it is possible to provide a composition for external use that ensures formulation stability and provides an excellent feeling on the skin when used. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0016] [External composition] The composition for external use of the present invention comprises: (A) at least one selected from the group consisting of terpene and its derivatives, ethanol, and glycerin; (B) A surfactant that is a fatty acid and / or a derivative thereof and does not contain a polyoxyethylene structure or a hydrogenation site in its structure. Contains:

[0017] (Component (A)) Terpenes (also referred to as terpenoids in this specification) are compounds having the chemical formula CH 2 =C(CH 3 )CH=CH 2 It means an organic compound having isoprene represented by the formula (I), which may have a chain structure or a ring structure. In this specification, complex terpenes partially containing an isoprene structure are also included in the terpenes. Specific examples include monoterpenes, diterpenes, triterpenes, squalene, tetraterpenes, carotenoids, and other complex terpenes such as α-carotene, β-carotene, astaxanthin, canthaxanthin, abscisic acid, vitamin A, and vitamin E.

[0018] Terpenes and their derivatives include, for example, monoterpenes, which are compounds that have a structure consisting of two isoprene units and are known as cooling agents. There are no particular limitations on the monoterpene, so long as it is physiologically or pharma- ceutically acceptable. The monoterpene may be any of d-, l- or dl-isomers.

[0019] Specific examples of monoterpenes include monocyclic monoterpenes such as menthol, eugenol, thymol, limonene, anethole, cymene, and terpineol, bicyclic monoterpenes such as camphor, borneol, cineole, pinene, camphene, isoborneol, and fenthenol, and acyclic monoterpenes such as geraniol, nerol, myrcene, myrcenol, linalool, linalool acetate, and lavandulol.

[0020] From the viewpoint of pursuing an excellent feel on the skin, the monoterpene may include at least one selected from the group consisting of monocyclic monoterpenes such as menthol, eugenol, thymol, limonene, anethole, cymene, and terpineol, and bicyclic monoterpenes such as camphor, borneol, cineol, pinene, camphene, isoborneol, and fenthenol; at least one selected from the group consisting of menthol, camphor, and borneol, and menthol and / or camphor.

[0021] As the monoterpene, an essential oil containing a monoterpene may be used. Examples of such essential oils include cool mint oil, peppermint oil, peppermint oil, eucalyptus oil, bergamot oil, spearmint oil, rose oil and camphor oil. From the viewpoint of pursuing an excellent feeling of use on the skin, the essential oil containing a monoterpene may include at least one selected from the group consisting of eucalyptus oil, cool mint oil, peppermint oil, peppermint oil and camphor oil, at least one selected from the group consisting of eucalyptus oil, cool mint oil, peppermint oil and peppermint oil, at least one selected from the group consisting of eucalyptus oil, cool mint oil and peppermint oil, at least one selected from the group consisting of eucalyptus oil and / or cool mint oil.

[0022] From the viewpoint of pursuing an excellent feel on the skin, examples of terpenes and derivatives thereof include at least one selected from the group consisting of glycyrrhetinic acid, menthol, camphor, and eucalyptus oil, at least one selected from the group consisting of glycyrrhetinic acid, menthol, and camphor, and at least one selected from the group consisting of glycyrrhetinic acid and / or menthol.

[0023] The content of the (A) component is appropriately set depending on the balance with other components, and is not particularly limited, but examples of the content include 0.01 mass% or more, 0.05 mass% or more, 0.1 mass% or more, 0.5 mass% or more, 1 mass% or more, 2 mass% or more, 3 mass% or more, 4 mass% or more, 5 mass% or more, and the like, relative to the total amount of the composition.

[0024] The content of component (A) is, for example, 20% by mass or less, 19% by mass or less, 18% by mass or less, 17% by mass or less, 16% by mass or less, 15% by mass or less, 14% by mass or less, 13% by mass or less, based on the total amount of the composition. Lower, 12% by mass or less, 11% by mass or less, 10% by mass or less, 9% by mass or less, 8% by mass or less, 7% by mass or less, 6% by mass or less, 5% by mass or less, 4% by mass or less, 3% by mass or less, 2% by mass or less.

[0025] The content of the component (A) relative to the total amount of the composition can be, for example, 0.01 to 20 mass%, 0.01 to 15 mass%, 0.01 to 10 mass%, 0.01 to 5 mass%, 0.1 to 20 mass%, 0.1 to 15 mass%, 0.1 to 10 mass%, 0.1 to 5 mass%, 0.5 to 20 mass%, 0.5 to 15 mass%, 0.5 to 10 mass%, 0.5 to 5 mass%, 1 to 20 mass%, 1 to 15 mass%, 1 to 10 mass%, 1 to 5 mass%, and the like.

[0026] (Component (B): Surfactant) The fatty acid can be any known fatty acid, and is not particularly limited. The fatty acid can be a saturated fatty acid or an unsaturated fatty acid, and can be a straight-chain or branched-chain structure. For example, the fatty acid can be a fatty acid having 12 to 24 carbon atoms, and preferably has 12 to 22 carbon atoms.

[0027] Examples of fatty acids include linear saturated fatty acids (solid at room temperature) such as lauric acid, myristic acid, palmitic acid, stearic acid, or behenic acid; unsaturated fatty acids (liquid at room temperature) such as oleic acid, linoleic acid, linolenic acid, palmitoleic acid, eicosapentaenoic acid, vaccenic acid, or docosahexaenoic acid; or branched fatty acids such as isostearic acid or lanolin fatty acid, or 12-hydroxystearic acid.

[0028] The fatty acid derivative can be a known fatty acid, and is not particularly limited. From the viewpoint of achieving the effects of the present invention, the fatty acid derivative is preferably one that does not contain a polyoxyethylene structure or a hydrogenation site in its structure, and includes at least one selected from the group consisting of non-polyoxyethylene type nonionic surfactants, N-acylamino acid salts, and phospholipids.

[0029] Examples of non-polyoxyethylene type nonionic surfactants include: Monoglycerin fatty acid esters such as glyceryl monocaprylate, glyceryl monocaprate, glyceryl monolaurate, glyceryl monomyristate, glyceryl monopalmitate, glyceryl monostearate, glyceryl monoisostearate, glyceryl monobehenate, glyceryl monooleate, and glyceryl monoerucate; Polyglycerol fatty acid esters such as polyglyceryl monostearate, polyglyceryl monoisostearate, and polyglyceryl diisostearate; sucrose fatty acid esters such as sucrose caprylate, sucrose caprate, sucrose laurate, sucrose myristic acid ester, sucrose palmitate, sucrose stearate, sucrose oleate, sucrose isostearate, sucrose linoleate, sucrose linolenate, sucrose coconut oil fatty acid ester, sucrose behenate, and sucrose erucate; Sorbitan fatty acid esters such as sorbitan sesquioleate, sorbitan monostearate, sorbitan monooleate, and sorbitan trioleate etc.

[0030] The (B) component exemplified above is, for example, at least one selected from the group consisting of fatty acids, phospholipids, polyglycerin fatty acid esters, sorbitan fatty acid esters, and monoglycerin fatty acid esters, more preferably at least one selected from the group consisting of fatty acids, phospholipids, polyglycerin fatty acid esters, and sorbitan fatty acid esters, and even more preferably at least one selected from the group consisting of palmitic acid, stearic acid, soybean lecithin, polyglyceryl stearate, and sorbitan trioleate. In another embodiment, it is also suitable to use two or more of the (B) components exemplified above. Examples of combinations of two or more of the (B) components include a combination containing a fatty acid and a phospholipid, a combination containing two of the fatty acids, a combination containing a fatty acid and a polyglycerin fatty acid ester, a combination containing a fatty acid and a sorbitan fatty acid ester, a combination containing a fatty acid and a monoglycerin fatty acid ester, a combination containing a phospholipid and a sorbitan fatty acid ester, and a combination containing a phospholipid and a monoglycerin fatty acid ester.

[0031] Furthermore, from the viewpoint of achieving the effects of the present invention, examples of fatty acid derivatives include N-acylamino acid salts, N-acyl glutamic acid salts, and at least one selected from the group consisting of potassium lauroyl glutamate, monosodium N-lauroyl glutamate, disodium N-stearoyl glutamate, and monosodium N-myristoyl-L-glutamate.

[0032] Furthermore, from the viewpoint of achieving the effects of the present invention, examples of fatty acid derivatives include phospholipids, for example, lecithin, and preferably soybean lecithin.

[0033] The content of the (B) component is appropriately set depending on the balance with other components, and is not particularly limited, but examples of the content relative to the total amount of the composition include 0.01 mass% or more, 0.05 mass% or more, 0.1 mass% or more, 0.5 mass% or more, 1 mass% or more, 2 mass% or more, 3 mass% or more, 4 mass% or more, 5 mass% or more, and the like.

[0034] The content of component (B) is, for example, 20% by mass or less, 19% by mass or less, 18% by mass or less, 17% by mass or less, 16% by mass or less, 15% by mass or less, 14% by mass or less, 13% by mass or less, based on the total amount of the composition. Lower, 12% by mass or less, 11% by mass or less, 10% by mass or less, 9% by mass or less, 8% by mass or less, 7% by mass or less, 6% by mass or less, 5% by mass or less, 4% by mass or less, 3% by mass or less, 2% by mass or less.

[0035] The content of the component (B) relative to the total amount of the composition can be, for example, 0.01 to 20 mass%, 0.01 to 15 mass%, 0.01 to 10 mass%, 0.01 to 5 mass%, 0.1 to 20 mass%, 0.1 to 15 mass%, 0.1 to 10 mass%, 0.1 to 5 mass%, 0.5 to 20 mass%, 0.5 to 15 mass%, 0.5 to 10 mass%, 0.5 to 5 mass%, 1 to 20 mass%, 1 to 15 mass%, 1 to 10 mass%, 1 to 5 mass%, and the like.

[0036] When a fatty acid is used as the (B) component, the total content of the fatty acid alone can be, for example, 0.1 to 20 mass%, 0.1 to 15 mass%, 0.1 to 10 mass%, 0.1 to 5 mass%, 0.5 to 20 mass%, 0.5 to 15 mass%, 0.5 to 10 mass%, 0.5 to 5 mass%, 1 to 20 mass%, 1 to 15 mass%, 1 to 10 mass%, and the like, relative to the total amount of the composition.

[0037] The content of the (B) component per 1 part by mass of the (A) component is not particularly limited as long as the effects of the present invention are achieved, but examples include 0.1 parts by mass or more, 0.2 parts by mass or more, 0.3 parts by mass or more, 0.4 parts by mass or more, 0.5 parts by mass or more, 0.6 parts by mass or more, and also less than 10 parts by mass, 9 parts by mass or less, 8 parts by mass or less, 7 parts by mass or less, 6 parts by mass or less, 5 parts by mass or less, 4 parts by mass or less, 3 parts by mass or less, 2 parts by mass or less, 1 part by mass or less, and the like. The content of the (B) component relative to 1 part by mass of the (A) component is not particularly limited, and may be, for example, 0.1 to 10 parts by mass, 0.1 to 9 parts by mass, 0.1 to 8 parts by mass, 0.1 to 7 parts by mass, 0.1 to 6 parts by mass, 0.1 to 5 parts by mass, 0.1 to 4 parts by mass, 0.1 to 3 parts by mass, 0.1 to 2 parts by mass, 0.1 to 1 part by mass, 0.2 to 10 parts by mass, 0.2 to 9 parts by mass, 0.2 to 8 parts by mass, 0.2 to 7 parts by mass, 0.2 to 6 parts by mass, 0.2 to 5 parts by mass, 0.2 to 4 parts by mass, 0.2 to 3 parts by mass, 0.2 to 2 parts by mass, 0.2 to 1 part by mass, 0.3 to 10 parts by mass, 0.3 to 9 parts by mass, 0.3 to 8 parts by mass, 0.3-7 parts by mass, 0.3-6 parts by mass, 0.3-5 parts by mass, 0.3-4 parts by mass, 0.3-3 parts by mass, 0.3-2 parts by mass, 0.3-1 parts by mass, 0.4-10 parts by mass, 0.4-9 parts by mass, 0.4-8 parts by mass, 0.4-7 parts by mass, 0.4-6 parts by mass, 0.4-5 parts by mass, 0.4-4 parts by mass .

[0038] The composition of the present invention preferably does not substantially contain any surfactant other than the component (B). In this specification, "substantially does not contain" means that the amount of surfactant other than the component (B) is preferably 10% by mass or less, more preferably 5% by mass or less, even more preferably 3% by mass or less, particularly preferably 1% by mass or less, and most preferably 0% by mass, based on the total amount of surfactants.

[0039] (water) The composition of the present invention preferably contains water. The content of water is not limited, but may be, for example, 10% by mass or more, 20% by mass or more, 30% by mass or more, 40% by mass or more, 50% by mass or more, 55% by mass or more, 60% by mass or more, 70% by mass or more, 80% by mass or more, etc., based on the total amount of the composition. The content of water may be, for example, 90% by mass or less, 85% by mass or less, 80% by mass or less, 70% by mass or less, 65% by mass or less, etc., based on the total amount of the composition. The water content, relative to the total amount of the composition, can be, for example, 10 to 90 mass%, 10 to 80 mass%, 10 to 70 mass%, 10 to 65 mass%, 20 to 90 mass%, 20 to 80 mass%, 20 to 70 mass%, 20 to 65 mass%, 30 to 90 mass%, 30 to 80 mass%, 30 to 70 mass%, 30 to 65 mass%, 40 to 90 mass%, 40 to 80 mass%, 40 to 70 mass%, 40 to 65 mass%, 50 to 90 mass%, 50 to 80 mass%, 50 to 70 mass%, 50 to 65 mass%, and the like.

[0040] ((C) Other Ingredients) In addition to the above-mentioned components, the topical composition of the present invention preferably further contains (C) arginine and / or lactic acid.

[0041] Arginine may be in a free form or in the form of a medicamentously, pharmacologically (pharmaceutical) or physiologically acceptable salt.

[0042] Specific examples of arginine salts include inorganic acid salts such as hydrochloride, etc. Arginine and its salts may be in the D-, L- or DL-form, with the L-form being preferred.

[0043] As arginine and its salts, arginine and its inorganic acid salts are preferred, arginine and arginine hydrochloride are more preferred, and arginine is even more preferred.

[0044] The arginine or salt thereof may be a commercially available product. The arginine or salt thereof may be used alone or in combination of two or more kinds.

[0045] Lactic acid may be in a free form or in the form of a medicamentically, pharmacologically (pharmaceutical) or physiologically acceptable salt.

[0046] Specific examples of salts of lactic acid include inorganic acid salts such as alkali metal salts, etc. Lactic acid and its salts may be in the D-, L- or DL-form, with the L-form being preferred.

[0047] As lactic acid and its salts, lactic acid and its inorganic acid salts are preferred, lactic acid and sodium lactate are more preferred, and lactic acid is even more preferred.

[0048] Lactic acid and its salts may be commercially available. Lactic acid and its salts may be used alone or in combination of two or more.

[0049] The type of component (C) is appropriately determined depending on the balance with other components, and is not particularly limited. From the viewpoint of significantly achieving the effects of the present invention, however, arginine and / or lactic acid are preferred, and arginine is more preferred.

[0050] The content of the (C) component is appropriately set depending on the balance with other components, and is not particularly limited, but examples of the content include 0.01 mass% or more, 0.05 mass% or more, 0.1 mass% or more, 0.5 mass% or more, 1 mass% or more, 2 mass% or more, 3 mass% or more, 4 mass% or more, 5 mass% or more, and the like, relative to the total amount of the composition.

[0051] The content of component (C) is, for example, 20% by mass or less, 19% by mass or less, 18% by mass or less, 17% by mass or less, 16% by mass or less, 15% by mass or less, 14% by mass or less, 13% by mass or less, based on the total amount of the composition. Lower, 12% by mass or less, 11% by mass or less, 10% by mass or less, 9% by mass or less, 8% by mass or less, 7% by mass or less, 6% by mass or less, 5% by mass or less, 4% by mass or less, 3% by mass or less, 2% by mass or less.

[0052] The content of the component (C) relative to the total amount of the composition can be, for example, 0.01 to 20 mass%, 0.01 to 15 mass%, 0.01 to 10 mass%, 0.01 to 5 mass%, 0.1 to 20 mass%, 0.1 to 15 mass%, 0.1 to 10 mass%, 0.1 to 5 mass%, 0.5 to 20 mass%, 0.5 to 15 mass%, 0.5 to 10 mass%, 0.5 to 5 mass%, 1 to 20 mass%, 1 to 15 mass%, 1 to 10 mass%, 1 to 5 mass%, and the like.

[0053] The content of the (A) component per 1 part by mass of the (C) component is not particularly limited as long as the effects of the present invention are achieved, but examples include 0.1 parts by mass or more, 0.5 parts by mass or more, 1 part by mass or more, 2 parts by mass or more, 3 parts by mass or more, 4 parts by mass or more, 5 parts by mass or more, and also less than 50 parts by mass, 45 parts by mass or less, 40 parts by mass or less, 35 parts by mass or less, 30 parts by mass or less, 25 parts by mass or less, and the like. The content of the (B) component per 1 part by mass of the (A) component is not particularly limited, and may be, for example, 0.1 to 50 parts by mass, 0.1 to 45 parts by mass, 0.1 to 40 parts by mass, 0.1 to 35 parts by mass, 0.1 to 30 parts by mass, 0.1 to 25 parts by mass, 0.5 to 50 parts by mass, 0.5 to 45 parts by mass, 0.5 to 40 parts by mass, 0.5 to 35 parts by mass, 0.5 to 30 parts by mass, 0.5 to 25 parts by mass, 1 to 50 parts by mass, 1 to 45 parts by mass, 1 to 40 parts by mass, 1 to 35 parts by mass, 1 to 30 parts by mass, 1 to 2 5 parts by mass, 2 to 50 parts by mass, 2 to 45 parts by mass, 2 to 40 parts by mass, 2 to 35 parts by mass, 2 to 30 parts by mass, 2 to 25 parts by mass, 3 to 50 parts by mass, 3 to 45 parts by mass, 3 to 40 parts by mass, 3 to 35 parts by mass, 3 to 30 parts by mass, 3 to 25 parts by mass, 4 ~50 parts by weight, 4-45 parts by weight, 4-40 parts by weight, 4-35 parts by weight, 4-30 parts by weight, 4-25 parts by weight, 5-50 parts by weight, 5-45 parts by weight, 5-40 parts by weight, 5-35 parts by weight, 5-30 parts by weight, 5-25 parts by weight, and the like.

[0054] The content of the (B) component relative to 1 part by mass of the (C) component is not particularly limited as long as the effects of the present invention are exhibited, but examples thereof include 0.1 parts by mass or more, 0.5 parts by mass or more, 1 part by mass or more, 2 parts by mass or more, 3 parts by mass or more, 4 parts by mass or more, 5 parts by mass or more, etc., and less than 30 parts by mass, 25 parts by mass or less, 20 parts by mass or less, 15 parts by mass or less, 10 parts by mass or less, etc. In addition, the content of the (B) component relative to 1 part by mass of the (A) component is not particularly limited, but examples thereof include 0.1 to 30 parts by mass, 0.1 to 25 parts by mass, 0.1 to 20 parts by mass, 0.1 to 15 parts by mass, 0.1 to 10 parts by mass, 0.5 to 30 parts by mass, 0.5 to 25 parts by mass, 0.5 to 20 parts by mass, 0.5 to 15 parts by mass, 0.5 to 10 parts by mass, 1 to 30 parts by mass, 1 to 25 parts by mass, 1 to 20 parts by mass, 1 to 15 parts by mass, 1 to 15 parts by mass, 1 to 20 ... ~10 parts by mass, 2-30 parts by mass, 2-25 parts by mass, 2-20 parts by mass, 2-15 parts by mass, 2-10 parts by mass, 3-30 parts by mass, 3-25 parts by mass, 3-20 parts by mass, 3-15 parts by mass, 3-10 parts by mass, Examples include 4 to 30 parts by mass, 4 to 25 parts by mass, 4 to 20 parts by mass, 4 to 15 parts by mass, 4 to 10 parts by mass, 5 to 30 parts by mass, 5 to 25 parts by mass, 5 to 20 parts by mass, 5 to 15 parts by mass, and 5 to 10 parts by mass.

[0055] (Base, carrier, additive, etc.) From the viewpoint of improving the feeling of use, stability, etc., the composition of the present invention may contain a base, carrier, additive, etc. in addition to the above-mentioned components, so long as the effects of the present invention are not hindered.

[0056] Examples of the base, carrier, or additive include higher fatty acids, higher alcohols, hydrocarbons, fats and oils, waxes, ester oils, silicone oils, moisturizing ingredients, polyhydric alcohols, thickeners, preservatives or antiseptics, pH adjusters, chelating agents, etc. These ingredients can be used alone or in any combination of two or more.

[0057] Examples of higher alcohols include higher alcohols having 12 to 22 carbon atoms, sterols, etc. Preferred examples include linear saturated alcohols (solid at room temperature) such as lauryl alcohol, myristyl alcohol, cetanol, cetostearyl alcohol, stearyl alcohol, arachyl alcohol, and behenyl alcohol; unsaturated alcohols (liquid at room temperature) such as oleyl alcohol and selachyl alcohol; or hexyldecanol, isostearyl alcohol, octyldodecanol, decyltetradecanol, and lanolin alcohol.

[0058] Examples of hydrocarbons include petrolatum, paraffin, ceresin, isoparaffin, hard fat, microcrystalline wax, polybutene, polyethylene powder, liquid paraffin, squalane, gelled hydrocarbons (such as plastibase), ozokerite, α-olefin oligomers, light liquid paraffin, and hydrocarbons such as light liquid paraffin.

[0059] Examples of fats and oils include avocado oil, linseed oil, camellia oil, macadamia nut oil, corn oil, olive oil, safflower oil, apricot kernel oil, jojoba oil, grape seed oil, sunflower oil, almond oil, camellia oil, rapeseed oil, sesame oil, castor oil, cacao butter, coconut oil, hardened coconut oil, palm oil, palm kernel oil, Japan wax kernel oil, wheat germ oil, rice germ oil, rice bran oil, cottonseed oil, soybean oil, peanut oil, tea seed oil, evening primrose oil, kukui nut oil, hazelnut oil, shea butter, orange oil, and chamomile oil.

[0060] Examples of waxes include candelilla wax, rice bran wax, cotton wax, carnauba wax, lanolin, lanoline fatty acid isopropyl, POE lanolin alcohol ether, POE lanolin alcohol acetate, lanoline fatty acid polyethylene glycol, POE hydrogenated lanolin alcohol ether, shellac wax, beeswax, and Japan wax.

[0061] Ester oils include isopropyl myristate, butyl myristate, decyl myristate, myristyl myristate, cetyl myristate, isopropyl palmitate, cetyl palmitate, ethyl stearate, butyl stearate, stearyl stearate, isocetyl stearate, hexyl laurate, ethyl oleate, ethyl linoleate, isopropyl linoleate, cetyl caprylate, decyl oleate, oleyl oleate, isodecyl oleate, cetyl octanoate, 2-octyldodecyl myristate, 2-Octyldodecyl Dimethyloctanoate, Hexyldecyl Dimethyloctanoate, 2-Hexyldecyl Myristate, 2-Hexyldecyl Palmitate, Diisopropyl Adipate, 2-Hexyldecyl Adipate, Diethyl Sebacate, Diisopropyl Sebacate, Isocetyl Isostearate, Isostearyl Isostearate, Isononyl Isononanoate, Isotridecyl Isononanoate, Cholesteryl 12-Hydroxystearate, Cholesteryl Stearate, Cholesteryl Oleate, Phytos Macadamia Nut Fatty Acid teryl, phytosteryl oleate, inulin stearate, ethylene glycol di-2-ethylhexanoate, cetyl 2-ethylhexanoate, N-alkyl glycol monoisostearate, neopentyl glycol dicaprate, glycerin di-2-heptylundecanoate, tri-2-ethylhexyl trimellitate, tritridecyl trimellitate, trimethylolpropane tri-2-ethylhexylate, trimethylolpropane triisostearate, pentaerythritol tetra-2-ethylhexanoate, tri-2-ethylhexyl Glyceryl xanthate, trimethylolpropane triisostearate, cetyl 2-ethylhexanoate, glyceryl trimyristate, tri(caprylic / capric)glyceryl, tri(caprylic / capric / myristic / stearic)glyceryl, medium chain triglyceride, castor oil fatty acid methyl ester, di(phytosteryl / octyldodecyl) lauroyl glutamate, di(octyldodecyl / phytosteryl / behenyl) lauroyl glutamate, cetyl lactate, myristyl lactate, cyclohexane-1,Examples of suitable glyceryl triglyceride include bisethoxydiglycol 4-dicarboxylate, lanolin acetate, ethyl acetate, butyl acetate, amyl acetate, triethyl citrate, dimer dilinoleate (phytosteryl / isostearyl / cetyl / stearyl / behenyl), dimer dilinoleyl dimer dilinoleate, dipentaerythrityl tripolyhydroxystearate, and tri(behenic acid / isostearic acid / eicosanedioic acid)glyceryl.

[0062] Examples of silicone oils include siloxanes such as methylpolysiloxane, methylphenylpolysiloxane, decamethyltetrasiloxane, methylcyclopentasiloxane, highly polymerized methylpolysiloxane, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, methylhydrogenpolysiloxane, methyltrimethicone, dimethiconol, dimethiconol crosspolymer, alkyl-modified silicones such as caprylyl methicone, amino-modified silicones such as aminopropyl dimethicone and amodimethicone, crosslinked methylpolysiloxane, crosslinked alkyl-modified silicone, amino-modified silicone, polyether-modified silicone, polyglycerin-modified silicone, crosslinked polyether-modified silicone, crosslinked alkyl polyether-modified silicone, silicone / alkyl chain co-modified polyether-modified silicone, silicone / alkyl chain co-modified polyglycerin-modified silicone, polyether-modified branched silicone, polyglycerin-modified branched silicone, acrylic silicone, phenyl-modified silicone, and silicone resin.

[0063] Examples of moisturizing components include hyaluronic acid (including hydrolyzed hyaluronic acid, low molecular weight hyaluronic acid, etc.); salts of hyaluronic acid (for example, sodium hyaluronate, zinc hyaluronate, low molecular weight zinc hyaluronate, etc.); hyaluronic acid derivatives (acetylated hyaluronic acid or its salts (for example, sodium acetylated hyaluronate, zinc acetylated hyaluronate, etc.), crosslinked hyaluronic acid derivatives (sodium hyaluronate crosspolymer, etc.), sodium carboxymethyl hyaluronate, unsaturated hyaluronic acid or its salts, hydrolyzed hyaluronic acid, etc.), and the like. Alkyl (C12-13) glyceryl hyaluronate, cationic hyaluronic acid derivatives (hydroxypropyltrimonium hyaluronate, etc.), dimethylsilanol hyaluronate, etc.); chondroitin sulfate or its salts (sodium chondroitin sulfate, potassium chondroitin sulfate, sodium dermatan sulfate, potassium dermatan sulfate, etc.); heparinoids, amino acids such as alanine, serine, aspartic acid, glycine, proline, hydroxyproline, glucosamine, theanine, arginine, and their derivatives. Conductors; polyhydric alcohols; alkylene oxides such as PPG-17 buteth-17, PPG-25 sorbitol, polyoxyalkylene alkyl glucosides, PEG / PPG / polybutylene glycol-8 / 5 / 3 glycerin, polyoxyalkylene diglyceryl; glycosyl trehalose, trehalose; ceramide, glucosyl ceramide, cholesterol, phytosterol, cholesterol derivatives, phytosterol derivatives; 2-methacryloyloxyethyl phosphorylcholine-butyl methacrylate copolyester Examples of such ingredients include 2-methacryloyloxyphosphorylcholine-containing polymers such as polymer liquid and polymethacryloyloxyethyl phosphorylcholine; NMF-derived components such as lactic acid, sodium lactate, sodium pyrrolidone carboxylate, and urea; collagen, elastin, keratin, chitin, chitosan, and the like and their hydrolysates; hydroxyethyl urea; and components derived from plants (for example, aloe, seaweed, pueraria lobata, chlorella, lemongrass, chamomile, witch hazel, tea, shiso, grapefruit, and gynostemma pentaphyllum).

[0064] Examples of polyhydric alcohols include low molecular weight alcohols having two or more hydroxyl groups, such as glycerin, diglycerin, triglycerin, propylene glycol, dipropylene glycol, 1,3-butanediol, ethylene glycol, diethylene glycol, isoprene glycol, 1,3-butylene glycol, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, decanediol, neopentyl glycol, sorbitol, xylitol, erythritol, and mannitol.

[0065] Examples of thickeners include vinyl thickeners such as polyvinyl alcohol, polyvinylpyrrolidone, polyvinyl methyl ether, and carboxyvinyl polymers; cellulose thickeners such as methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxymethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, carboxymethylcellulose, carboxyethylcellulose, and hydrophobized hydroxypropylmethylcellulose; guar gum, sclerotium gum, tamarind gum, xanthan gum, dextran, pectin, pullulan, gelatin, locust bean gum, carrageenan, agar, biosaccharide gum, acrylic acid alkyl methacrylate copolymer, sodium polyacrylate, bentonite, dextrin fatty acid ester, dimethyl distearyl ammonium hectorite, sodium alginate, polyethylene glycol, trimethylammonium chloride hydroxypropyl guar gum, trimethylammonio chloride hydroxypropyl hydroxyethyl cellulose, (hydroxyethyl acrylate / Na acryloyldimethyl taurate) copolymer, (ammonium acryloyldimethyl taurate / vinylpyrrolidone) copolymer, and the like.

[0066] Examples of preservatives or antiseptics include benzoic acid, sodium benzoate, dehydroacetic acid, sodium dehydroacetate, isobutyl parahydroxybenzoate, isopropyl parahydroxybenzoate, butyl parahydroxybenzoate, ethyl parahydroxybenzoate, propyl parahydroxybenzoate, benzyl parahydroxybenzoate, methyl parahydroxybenzoate, phenoxyethanol, benzyl alcohol, methylisothiazoline, iodopropynyl butylcarbamate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, or 1,2-octanediol, and essential oils other than those mentioned above (such as turpentine oil and lavender oil).

[0067] Examples of pH adjusters include inorganic acids (hydrochloric acid, sulfuric acid, etc.), organic acids (lactic acid, citric acid, tartaric acid, malic acid, succinic acid), organic bases (triethanolamine, diisopropanolamine, triisopropanolamine, etc.), as well as salts thereof, inorganic bases (potassium hydroxide, sodium hydroxide, etc.), and the like.

[0068] Examples of chelating agents include ethylenediaminetetraacetic acid (edetic acid), ethylenediaminetetraacetate (sodium salt (sodium edetate: Japanese Pharmacopoeia, EDTA-2Na, etc.), potassium salt, etc.), phytic acid, gluconic acid, polyphosphoric acid, metaphosphoric acid, etc.

[0069] Although not limited, the topical composition of the present invention is preferably a composition consisting of only natural raw materials or naturally derived raw materials. Here, the term "natural raw materials" refers to raw materials obtained from animals, plants, or minerals and not intentionally chemically modified, which is the same as the term "natural raw materials" defined in ISO 16128. The term "natural raw materials" refers to raw materials obtained from animals, plants, or minerals and intentionally chemically modified. Alternatively, the topical composition of the present invention preferably has a natural origin index of 95% or more, more preferably 98% or more, even more preferably 99% or more, and particularly preferably 100%.

[0070] [Manufacturing method] The method for producing the topical composition of the present invention is not particularly limited and can be appropriately determined.

[0071] Specifically, the components may be heated to dissolve as necessary, mixed, and then stirred while cooling in a water bath, and then allowed to stand at room temperature, but the method is not particularly limited thereto.

[0072] [Formulation] The composition of the present invention is prepared into a composition for external use by mixing with, for example, a base or carrier usually used in pharmaceuticals or quasi-drugs, and, if necessary, with additives.

[0073] The form of the composition of the present invention is not particularly limited, but it is preferably in the form of a composition for external use.Such forms include, for example, cream, suspension, emulsion, gel, liniment, lotion, patch, etc.These preparations can be manufactured according to the method described in the General Provisions of Preparations of the Japanese Pharmacopoeia, 18th Edition.

[0074] [pH] The pH of the composition for external use of the present invention is usually pH 4.0 to 8.0, and may be pH 4.5 to 7.5, pH 5.0 to 7.5, pH 5.5 to 7.5, pH 6.0 to 7.5, pH 6.5 to 7.5, pH 7.0 to 7.5, etc. The pH can be adjusted, for example, by using a pH adjuster. However, this does not apply to formulations in which pH measurement is impossible or difficult.

[0075] [container] The topical composition of the present invention can be stored and used in a container of a shape and material appropriately selected according to the purpose and application. Specific examples of the container include a container with a nozzle, a container with a pump, a jar container, a tube container, a container with a hole in the inner plug, a container with a hinge cap, a sponge head container, a roll-on container, etc. Among these, a tube container is particularly preferable. By storing in these containers, the topical composition of the present invention can be applied directly or indirectly to the desired affected area. The nozzle or sponge can be designed to have a tapered or large diameter so that it can be applied to a narrow or wide area of ​​the affected area. After applying the composition according to this embodiment to the affected area, it can also be used by spreading it with a nonwoven fabric, fingers, etc.

[0076] Examples of materials for the container include polyethylene terephthalate, polybutylene terephthalate, polyethylene naphthalate, polypropylene, polyethylene (HDPE, LDPE, LLDPE, etc.), ABS resin, polycarbonate, fluororesin, polyvinyl chloride, polyamide, ethylene vinyl alcohol resin, polystyrene, glass, and metal (aluminum, etc.). Taking into consideration strength, flexibility, weather resistance, stability of components, etc., these materials can be used as container materials by performing various coating treatments, combining these materials by, for example, mixing them, or laminating them.

[0077] [Method of imparting a skin irritation reduction effect] The present invention also relates to a method for imparting a skin irritation reducing effect to an external use composition, comprising (A) at least one member selected from the group consisting of terpene and its derivatives, ethanol, and glycerin, and (B) a surfactant which is a fatty acid and / or a derivative thereof and does not contain a polyoxyethylene structure or a hydrogenation site in its structure, and which is substantially free of surfactants other than component (B). The contents, ratios, and other conditions of each component herein are in accordance with those described in [External Composition]. EXAMPLES

[0078] Next, the present invention will be specifically described with reference to examples, but the present invention is not limited to the following examples.

[0079] [Test Example 1. Evaluation test of stability and hardness] Compositions for topical use of the examples and comparative examples were prepared. The components and contents of each composition are as shown in Table 1.

[0080] Each Example containing component (A) and component (B), and Comparative Examples 1-1 and 1-2 using a surfactant containing a polyoxyethylene structure or a hydrogenation site in its structure instead of component (B) were prepared. Each topical composition was evaluated for structural durability, high temperature durability, and hardness.

[0081] (Method of evaluating structural durability) Using a rheometer (MCR102, manufactured by Anton Paar, MESURING CONE CP35-1 D; 35 mm; ANGLE 1°), the storage modulus and loss modulus were measured by changing the shear strain (γ) of the measurement sample logarithmically from 0.01 to 100% at a measurement temperature of 25°C and a constant frequency of strain amplitude of 1 Hz.

[0082] The evaluation was performed according to the following evaluation criteria, and the results are shown in Table 1. The value of the shear strain γ at the intersection of the storage modulus and the loss modulus represents the shear required to change from solid (semi-solid) to liquid properties. On the other hand, the value of the shear strain γ 1% / 0.1% of the storage modulus represents the shear required for the structure to begin to break down in the solid (semi-solid) state. Therefore, when the above two values ​​satisfy the following evaluation criteria, it is judged that the tested composition for external use can stably maintain the emulsion structure. When the above test shows that the composition has high structural stability, for example, when filled in a tube container or a jar container, dripping or leakage can be suppressed. In addition, when the composition for external use is applied to the skin, it is judged that the composition adheres to the skin more closely, the medicinal effect is more strongly felt, and dripping is less likely to occur during application, resulting in an excellent usability. ○: The shear strain γ at the intersection of the storage modulus and loss modulus is 1% or more, and the shear strain γ 1% / 0.1% of the storage modulus is 0.15 or more. △: The shear strain γ at the intersection of the storage modulus and loss modulus is 1% or more, and the shear strain γ 1% / 0.1% of the storage modulus is less than 0.15. ×: The shear strain γ at the intersection of the storage modulus and loss modulus is less than 1%, and the shear strain γ 1% / 0.1% of the storage modulus is less than 0.15.

[0083] (Method of evaluating high temperature durability) The composition was visually inspected. After one day of preparation and storage at room temperature, 15 g of each composition was placed in a 30 mL glass bottle, stored at 40°C for 48 hours, and visually inspected. The composition was evaluated as having shape retention as a formulation, as ○, and as being liquefied, as ×. The results are shown in Table 1.

[0084] (Hardness evaluation method) The hardness of the prepared topical composition was measured using a rheometer (product name "SUN RHEO METER CR-100", manufactured by Sun Scientific Co., Ltd.). The hardness was measured by inserting a cylindrical adapter (adapter) with a diameter of 20 mm into the center of the cylindrical container at a speed of 20 mm / min, and the maximum value (unit: g) was measured for 30 seconds from the insertion. The results are also shown in Table 1.

[0085] [Table 1]

[0086] As shown in Table 1, in Comparative Examples 1-1 and 1-2, a surfactant containing a polyoxyethylene structure or a hydrogenation site on its structure was used, and therefore, when used in combination with component (A), the structural durability and high temperature durability were reduced, and the stability and feeling of use were impaired. On the other hand, in each Example, since component (A) and component (B) coexist, structural durability and high temperature durability were maintained at a high level, and the stability during use was good. Although not limited thereto, in particular, in Examples that satisfy the evaluation criteria of a shear strain γ at the intersection of the storage modulus and the loss modulus being 1% or more, and a shear strain γ 1% / 0.1% of the storage modulus being 0.15 or more, the emulsion structure was stably maintained, and, for example, dripping and leakage were suppressed when filling a container. Furthermore, when applied to the skin, the feeling of adhesion was enhanced, and a feeling of medicinal efficacy was felt to be high.

[0087] [Prescription example] Formulation examples are shown in Table 2 below. All units are mass %. In the case of a cream formulation, it can be stored in a jar container made of polypropylene or polyethylene terephthalate, or a tube container made of polyethylene, polypropylene, polyethylene terephthalate, or aluminum laminate.

[0088] In the case of a milky lotion or emulsion form, the composition can be stored in a bottle container made of polypropylene, polyethylene, or polyethylene terephthalate, or a pump container made of polypropylene, polyethylene, or polyethylene terephthalate.

[0089] [Table 2]

Claims

1. (A) at least one selected from the group consisting of terpene and its derivatives, ethanol, and glycerin; and (B) A surfactant which is a fatty acid and / or a derivative thereof and does not contain a polyoxyethylene structure or a hydrogenation site in its structure. and is substantially free of any surfactant other than (B).

2. The composition according to claim 1, further comprising (C) arginine and / or lactic acid.

3. The composition for external use according to claim 1 or 2, wherein the component (B) is at least one selected from the group consisting of palmitic acid, stearic acid, soybean lecithin, polyglyceryl stearate, and sorbitan trioleate.

4. (A) a composition for external use containing at least one selected from the group consisting of terpene and its derivatives, ethanol, and glycerin, A method for imparting a skin irritation reducing effect to the topical composition, characterized in that the composition contains (B) a surfactant which is a fatty acid and / or a derivative thereof and does not contain a polyoxyethylene structure or a hydrogenation site in its structure, and the composition does not substantially contain any surfactants other than the (B) component.

Images