Tablet property improver and tablet property improvement method, filling property improver and filling property improvement method, and tablet and manufacturing method thereof

Abstract

To provide a tablet property improver and a tablet property improvement method, which can improve the tablet property even if a tablet contains a component which applies unfavorable effect on tablet property and tableting suitability, and a filling property improver and a filling property improvement method, which can improve filling property into a mortar of a tableting machine, and a tablet whose tablet property and filling property into the mortar of the tableting machine is improved and a manufacturing method of the tablet.SOLUTION: A tablet property improver for improving the physical property of a tablet containing a component having an angle of repose of 60° or more contains petrified seaweed powder, in which the petrified seaweed powder is blended in the tablet, in an amount of 2 to 20% by mass.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to a tablet physical property improving agent and a tablet physical property improving method, a filling property improving agent and a filling property improving method for improving the filling property of a tableting composition into a die of a tablet press, and a tablet and a method for producing the same. [Background technology]

[0002] In recent years, due to factors such as irregular eating habits and increased awareness of beauty, there has been an increasing demand for tablets such as dietary supplements and supplements that contain functional ingredients such as nutrients such as proteins, amino acids, vitamins, minerals, and extracts derived from plants and animal materials that contain various nutrients, in order to efficiently replenish necessary nutrients.

[0003] From the viewpoints of quality and manufacturing, tablets and their production require good tablet properties and tableting suitability, and therefore technologies capable of improving tablet properties and tableting suitability are being developed.

[0004] For example, a powdered flowability improver made of calcium carbonate having an average particle size of 0.4 μm or less has been proposed as a technology for providing a flowability improver that has a flowability improving effect equal to or greater than that of conventional flowability improvers such as silicon dioxide, silicic acid, and talc, and also has a nutritional improving effect (see, for example, Patent Document 1).

[0005] In order to provide a technology capable of improving the content uniformity of the active ingredient and imparting sufficient hardness to the molded body, a method for producing a molded body has been proposed, which includes a step of molding a composition containing crystalline cellulose having an average particle size of less than 30 μm and an angle of repose of 55° or more, light anhydrous silicic acid, and one or more active ingredients by direct compression (see, for example, Patent Document 2).

[0006] As a technology for providing a tablet that has good storage stability and quickly liquefies when used, particularly a tablet that quickly liquefies in the mouth when chewed and has a good taste, a tablet has been proposed that contains a water-soluble binder and is composed of an agglomerate containing at least 25% by weight of a carbohydrate-based substance and an active ingredient dispersed in the agglomerate, wherein the carbohydrate-based substance contains about 1% to about 10% by weight of binder, the tablet has a relatively hard outer shell formed from compressed agglomerates on the tablet surface, the shell is stable against liquefaction when contacted with liquid, the shell and the tablet break into fragments, and when the agglomerate under the shell comes into contact with liquid, the tablet can be quickly liquefied (see, for example, Patent Document 3).

[0007] As a technique for providing a tablet having excellent long-term sustained disintegrability when compressed and having excellent shape-retaining stability by increasing the strength of the tablet, an antacid / swallowable tablet has been proposed, which is mainly composed of magnesium oxide particles, and is characterized in that (a) the magnesium oxide particles have an average secondary particle diameter of 0.5 to 10 μm as measured by a laser diffraction scattering method, (b) the content of the magnesium oxide particles is 85 to 96 wt %, (c) the content of crystalline cellulose as a binder is 2 to 8 wt %, (d) the content of croscarmellose sodium as disintegrant-I is 0.8 to 2.5 wt %, (e) the content of insoluble polyvinylpyrrolidone as disintegrant-II is 1 to 3.5 wt %, and (f) the content of a lubricant is 0.5 to 2 wt % (see, for example, Patent Document 4). [Prior art documents] [Patent documents]

[0008] [Patent Document 1] JP 2022-74586 A [Patent Document 2] JP 2018-2695 A [Patent Document 3] Japanese Patent Application Publication No. 61-225119 [Patent Document 4] International Publication No. 2011 / 030659 Summary of the Invention [Problem to be solved by the invention]

[0009] According to the technology of the above-mentioned Patent Document 1, it is possible to provide a flowability improver that has a flowability improving effect equal to or greater than that of conventional flowability improvers such as silicon dioxide, silicic acid, talc, etc., and also has a nutritional improving effect. However, the present inventors have found that calcium carbonate with an average particle size of 0.4 μm or less has several problems in tablet production, such as a weak effect of increasing tablet hardness, a weak effect of improving disintegration time, a weak adhesion suppression effect on poorly adhesive raw materials, which makes it impossible to suppress adhesion to equipment and packaging materials during tableting, and a concern that segregation may occur during tableting due to the fine particles. In addition, commonly used calcium carbonate having an average particle size of more than 0.4 μm has problems such as a weak effect on increasing tablet hardness, a weak effect on improving disintegration time, and a weak effect on improving tableting suitability.

[0010] Furthermore, some of the various ingredients, such as nutrients and functional ingredients, that are mixed into tablets have undesirable effects on the physical properties and tableting suitability of the tablets. Therefore, there is a strong demand for the development of new technologies that can improve tablet properties and tableting suitability even when the tablet contains ingredients that have an unfavorable effect on these properties and tableting suitability.

[0011] The present invention aims to solve the above-mentioned problems in the prior art and to achieve the following objects: That is, the present invention aims to provide a tablet physical property improving agent and a tablet physical property improving method capable of improving tablet physical properties even when a component that has an unfavorable effect on tablet physical properties and tableting suitability is contained, a filling property improving agent and a filling property improving method capable of improving the filling property into the dies of a tablet press, and a tablet having improved tablet physical properties and filling property into the dies of a tablet press and a method for producing the same. [Means for solving the problem]

[0012] In order to solve the above problems, the inventors conducted extensive research and discovered that by adding petrified seaweed powder to ingredients that have an unfavorable effect on tablet properties and tableting suitability, tablet hardness and tablet disintegration properties can be improved, making it possible to produce tablets that have high hardness, a short disintegration time, and an excellent balance between hardness and disintegration properties, and that the ability of the tableting composition to be filled into the dies of a tablet press can be improved, thereby improving tableting suitability.

[0013] The present invention is based on the findings of the present inventors, and the means for solving the above problems are as follows. <1> A tablet physical property improver for improving the physical properties of a tablet containing a component having an angle of repose of 60° or more, Contains petrified seaweed powder, The tablet physical property improving agent is characterized in that the petrified seaweed powder is blended in an amount of 2 to 20% by mass in the tablet. <2> The improvement in the physical properties of the tablet is at least one of an improvement in tablet hardness and an improvement in tablet disintegrability. <1> The tablet physical property improving agent according to claim 1, <3> A method for improving the physical properties of a tablet containing a component having an angle of repose of 60° or more, comprising: The above <1> from <2> The present invention relates to a method for improving tablet physical properties, the method comprising the step of blending the tablet physical property improver described in any one of the above into a tableting composition. <4> A filling property improver for improving the filling property of a tableting composition containing a component having an angle of repose of 60° or more into a die of a tablet press, comprising: Contains petrified seaweed powder, The fillability improving agent is characterized in that the petrified seaweed powder is blended in an amount of 2 to 20% by mass in the tableting composition. <5> A method for improving the filling property of a tableting composition containing a component having an angle of repose of 60° or more into a die of a tablet press, comprising: The above <4> The method for improving filling property is characterized by comprising blending the filling property improver described in the above into the tableting composition. <6> Contains a component having an angle of repose of 60° or more and petrified seaweed powder, The tablet is characterized in that the content of the petrified seaweed powder in the tablet is 2 to 20% by mass. <7> The method includes tableting a composition for tableting, the composition comprising a component having an angle of repose of 60° or more and a powder of petrified seaweed, The method for producing tablets is characterized in that the content of the petrified seaweed powder in the composition for tableting is 2 to 20% by mass. Effect of the Invention

[0014] According to the present invention, it is possible to solve the above-mentioned problems in the conventional art and achieve the above-mentioned object, and to provide a tablet physical property improving agent and a tablet physical property improving method that can improve the tablet physical properties even when the tablet contains components that have an undesirable effect on the tablet physical properties and tableting suitability, a filling property improving agent and a filling property improving method that can improve the filling ability into the dies of a tablet press, and a tablet having improved tablet physical properties and filling ability into the dies of a tablet press and a method for producing the same. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0015] (tablet) The tablet of the present invention contains at least a component having an angle of repose of 60° or more and powder of petrified seaweed, and further contains other components as necessary.

[0016] <Components with a repose angle of 60° or more> Components with an angle of repose of 60° or more are powders that have very poor tableting suitability when used alone, and even when mixed with auxiliary materials and tableted, it may be difficult to achieve high hardness. These components have an unfavorable effect on the tablet properties and tableting suitability. According to the present invention, even when a component having an angle of repose of 60° or more is contained, it is possible to obtain good tablet properties and suitability for tablet compression.

[0017] In this specification, the term "angle of repose" refers to the "dynamic angle of repose" and refers to the angle between the flow surface and the horizontal plane measured with an attached protractor using a cylindrical rotation method angle of repose measuring instrument FSA-100 (manufactured by Tsutsui Scientific Instruments Co., Ltd.) when 50 g of a measurement sample is placed in the attached measuring bottle and rotated at a rotation speed of 2.1 rpm.

[0018] The component having an angle of repose of 60° or more is not particularly limited and can be appropriately selected depending on the purpose, and examples thereof include dry yeast, whey protein, soy protein, powdered cellulose having an average particle size of 60 μm or less, crystalline cellulose having an average particle size of 60 μm or less, dietary fiber, ferric pyrophosphate, etc. These may be used alone or in combination of two or more. In addition, the petrified seaweed powder described below also has an angle of repose of 60° or more, but in this specification, the components having an angle of repose of 60° or more do not include petrified seaweed powder.

[0019] The method for preparing the dried yeast is not particularly limited, and any known method can be appropriately selected depending on the purpose. For example, a method in which live yeast from which impurities have been removed is washed with water and caustic soda, and then dried by drum drying can be mentioned.

[0020] The type of yeast in the dry yeast is not particularly limited and can be appropriately selected depending on the purpose. Examples of the yeast include beer yeast, happoshu yeast, yeast for beer-like beverages such as miscellaneous alcohol, sake yeast, wine yeast, whiskey yeast, other brewing yeast, baker's yeast, and the like. The genus of yeast in the dry yeast is not particularly limited and can be appropriately selected depending on the purpose. For example, the genus Saccharomyces may be mentioned. Specific examples of the yeasts of the genus Saccharomyces include Saccharomyces pastorianus.

[0021] The component having an angle of repose of 60° or more may be a commercially available product, or may be appropriately prepared.

[0022] The content of the component having an angle of repose of 60° or more in the tablet is not particularly limited and can be selected appropriately depending on the purpose, but is preferably more than 0% by mass and not more than 98% by mass, more preferably more than 0% by mass and not more than 75% by mass, and particularly preferably more than 0% by mass and not more than 50% by mass. The content of the component having an angle of repose of 60° or more in the tablet is a value rounded off to the first decimal place.

[0023] <Petrified seaweed powder> The petrified seaweed powder is a powder obtained by crushing petrified seaweed, which is a calcareous residue of seaweed, and is a raw material rich in minerals such as calcium and magnesium. The calcium content in the petrified seaweed powder is mainly calcium carbonate.

[0024] The average particle size of the petrified seaweed powder is about 2 to 10 μm. In this specification, the average particle size of the petrified seaweed powder refers to the volume average particle size. There are no particular limitations on the method for measuring the average particle diameter of the petrified seaweed powder, and it can be selected appropriately depending on the purpose. For example, the degree of particle size variation and its distribution state (particle size distribution) can be measured by irradiating the petrified seaweed powder with laser light and detecting and analyzing the intensity distribution pattern of the diffracted and scattered light emitted from it. Specifically, the measurement can be performed using a laser diffraction / scattering type particle size distribution measuring device (MT3300EXII, manufactured by Microtrack Bell).

[0025] The lithified seaweed is not particularly limited as long as it is obtained by adsorbing mineral components such as calcium and magnesium in the sea, and can be appropriately selected depending on the purpose. Calcareous residues of red algae are preferred, and calcareous residues of Corallinaceae seaweed are more preferred.

[0026] The Corallinaceae seaweed is not particularly limited and may be appropriately selected depending on the purpose, and examples thereof include Lithothamnium corallioides, Phymatolithon calcareum, Lithothamnium glaciale, etc. These Corallinaceae seaweeds are abundant in cold, calm seas, and the calcareous residues remaining after the Corallinaceae seaweeds die are 90% by mass or more inorganic and mainly consist of calcium carbonate and magnesium carbonate.

[0027] The content of mineral components in the petrified seaweed powder is not particularly limited and can be selected appropriately depending on the purpose, but it is preferable that the calcium content is 31% by mass or more and the magnesium content is 2% by mass or more.

[0028] The petrified seaweed powder may be a commercially available product or may be appropriately prepared. Examples of the commercially available products include Aqua Mineral (Biocon Japan), AQUAMIN (MARIGOT), and Seaweed Calcium IT-1 (Taiyo Kagaku).

[0029] The method for preparing the fossilized seaweed powder is not particularly limited and can be appropriately selected depending on the purpose. The fossilized seaweed can be used in a state where it has been dredged from the seabed, but since it contains impurities such as sand and shells, it is preferable that the impurities have been removed by washing some or all of the seaweed with seawater or fresh water, or by sieving or manually selecting the impurities, either alone or in combination. In addition, it is more preferable that the fossilized seaweed is, for example, dredged from the seabed, after removing the impurities, and then sterilized by hydrogen peroxide treatment or heat treatment, and dried.

[0030] The method for drying the fossilized seaweed is not particularly limited and can be appropriately selected depending on the purpose, and examples include sun drying, hot air drying, etc. The degree of drying may be such that the moisture content of the fossilized seaweed is sufficiently reduced, and for example, the moisture content is preferably 10% by mass or less, more preferably 5% by mass or less.

[0031] The method for powdering the fossilized seaweed is not particularly limited and can be appropriately selected depending on the purpose, and examples thereof include a method of pulverizing the fossilized seaweed using a ball mill, a hammer mill, a roller mill, etc. The order of powdering and drying is not particularly limited and can be appropriately selected depending on the purpose.

[0032] The content of the petrified seaweed powder in the tablet is not particularly limited as long as it is 2 to 20% by mass and can be appropriately selected depending on the purpose, but is preferably 2 to 12% by mass, and more preferably 3 to 12% by mass. The content of the petrified seaweed powder in the tablet is rounded to the nearest tenth.

[0033] <Other ingredients> The other components in the tablet are not particularly limited as long as they do not impair the effects of the present invention, and can be appropriately selected depending on the purpose. For example, functional components other than the above-mentioned components having an angle of repose of 60° or more; lubricants such as stearic acid, calcium stearate, magnesium stearate, sodium stearyl fumarate, sucrose fatty acid esters, talc, vegetable oils and fats, and hardened oils; disintegrants such as partially pregelatinized starch, sodium starch glycolate, croscarmellose sodium, and agar; excipients such as starch, lactose, dextrin, and corn starch; powdered cellulose; crystalline cellulose; hydroxypropyl cellulose, and hydroxypropyl methylcellulose. water-soluble polymers such as polyvinylpyrrolidone and polyvinyl alcohol; sugar alcohols such as reduced maltose syrup, xylitol, sorbitol, mannitol, and maltitol; disaccharides such as trehalose, palatinose, and isomalt; soybean polysaccharides; binders such as corn protein; silicon, such as anhydrous silicic acid, calcium silicate, light anhydrous silicic acid, hydrated silicon dioxide, and silicon dioxide, or a salt or oxide thereof; adhesives; colorants such as titanium oxide and iron oxide; pH adjusters or buffers such as phytic acid, citric acid, succinic acid, sodium citrate, sodium acetate, DL-malic acid, phosphoric acid, and disodium phosphate; and antioxidants.

[0034] The functional ingredient other than the ingredient having an angle of repose of 60° or more is not particularly limited, and ingredients used in nutritional supplements and the like can be appropriately selected according to the purpose. For example, vitamins such as vitamin A, vitamin B group, vitamin C, vitamin D, vitamin E, vitamin K, hesperidin, inositol, etc.; amino acids or salts thereof; peptide-containing substances containing milk-derived peptides such as casein hydrolysates, peptide-containing substances containing animal-derived peptides such as chicken cartilage-derived extracts and pig-derived extracts, peptide-containing substances containing plant-derived peptides such as maca extract and sesame extract, peptide-containing substances containing seaweed-derived peptides such as wakame extract and kombu extract, shark cartilage extract, salmon nasal cartilage extract, tuna Examples of such substances include peptide-containing substances such as peptide-containing substances containing peptides derived from fishes such as extracts and ray-derived extracts; animal extracts such as placenta extracts and collagen-containing extracts; minerals such as calcium, magnesium, zinc, iron, manganese, copper, selenium, chromium, and molybdenum; coenzyme Q10, α-lipoic acid, L-carnitine, collagen, hyaluronic acid, elastin, turmeric, glucosamine hydrochloride, chondroitin sulfate, silymarin, lutein, fermented soybean germ extract powder, pomegranate extract powder, and the like; components containing various polyphenols derived from ginkgo leaves, apples, guava, tea, pine, grapes, and salacia; plant extracts such as vegetable fermentation powder and Japanese and Chinese plant extract powder; and lactic acid bacteria powder. These may be used alone or in combination of two or more.

[0035] The other ingredients in the tablet may be used alone or in combination of two or more. Other ingredients in the tablet may be appropriately selected from commercially available products.

[0036] The content of other ingredients in the tablet is not particularly limited and can be appropriately selected depending on the purpose.

[0037] The shape, structure and size of the tablet are not particularly limited and can be appropriately selected depending on the purpose.

[0038] The tablets can be suitably used as dietary supplements or dietary supplements.

[0039] According to the present invention, by blending petrified seaweed powder with ingredients having an angle of repose of 60° or more, tablets with improved tablet properties and tableting suitability can be produced.

[0040] The method for producing the tablet is not particularly limited and can be appropriately selected depending on the purpose, but the tablet can be preferably produced by the tablet production method of the present invention described below.

[0041] (Tablet manufacturing method) The method for producing tablets of the present invention includes at least a tableting step, and may further include other steps as necessary.

[0042] <Tableting process> The tableting step is a step of tableting a composition for tableting containing a component having an angle of repose of 60° or more and petrified seaweed powder, thereby making it possible to obtain tablets.

[0043] The composition for tableting (hereinafter sometimes referred to as "tabletting powder") contains at least a component having an angle of repose of 60° or more and petrified seaweed powder, and further contains other components as necessary. The components having a repose angle of 60° or more, the petrified seaweed powder, and other components in the tablet powder are respectively the same as the components having a repose angle of 60° or more, the petrified seaweed powder, and other components in the tablet described in the (Tablet) section of the present invention above, and the preferred aspects are also the same. The content of each component in the composition for tableting is the same as the content of each component in the tablet described in the (Tablet) section of the present invention.

[0044] The method of tableting is not particularly limited and can be appropriately selected depending on the purpose. Examples of the method include direct tableting and granule compression. According to the present invention, by adding petrified seaweed powder to ingredients with an angle of repose of 60° or more, it is possible to improve tablet properties and tableting suitability without modifying powder properties by granulation, etc. Therefore, in the tablet manufacturing method of the present invention, direct tableting can also be suitably used.

[0045] The tableting can be carried out using known equipment, such as tablet presses (e.g., HT-APSS type, HT-AP-MS type, HT-X-SS type, HT-X-MS type (all manufactured by Hata Iron Works Co., Ltd.); VEL5, VIRGO, AQUARIUS, LIBRA (all manufactured by Kikusui Seisakusho Co., Ltd.); AUTOTAB-200 (manufactured by Ichihashi Seiki Co., Ltd.)).

[0046] The conditions for the tableting such as the tableting pressure are not particularly limited and can be appropriately selected depending on the purpose.

[0047] <Other processes> Other steps in the manufacturing method of the tablets are not particularly limited as long as they do not impair the effects of the present invention and can be appropriately selected depending on the purpose. For example, there can be a mixing step for preparing the powder for tableting.

[0048] <<Mixing process>> The mixing step is a step of mixing the above-mentioned component having a repose angle of 60° or more with the above-mentioned petrified seaweed powder to obtain a tablet powder. In the mixing step, the above-mentioned other components may be further mixed as necessary.

[0049] In the mixing process, the component having an angle of repose of 60° or more, the petrified seaweed powder, and, if necessary, the other components may be mixed together in one go, or any desired component may be mixed in multiple batches.

[0050] The mixing can be carried out using a known device, and examples of the device include a container tumbler, a V-type mixer, a Boley container mixer, and a rocking mixer. The mixing conditions such as temperature and time are not particularly limited and can be appropriately selected.

[0051] According to the tablet manufacturing method of the present invention, by blending petrified seaweed powder with ingredients having an angle of repose of 60° or more, tablets with improved tablet properties and tableting suitability can be produced easily and efficiently.

[0052] (Tablet property improver) The tablet property improving agent of the present invention is intended to improve the properties of tablets containing a component with an angle of repose of 60° or more, and contains at least petrified seaweed powder, and further contains other components as necessary. The components having a repose angle of 60° or more, the petrified seaweed powder, and other components in the tablet property improver are respectively the same as the components having a repose angle of 60° or more, the petrified seaweed powder, and other components in the tablet described in the (Tablet) section of the present invention above, and the preferred aspects are also the same.

[0053] The amount of the tablet property improving agent used is not particularly limited, and can be appropriately selected depending on the purpose, as long as the petrified seaweed powder is used in an amount that is 2 to 20% by mass in the tablet. However, it is preferable that the petrified seaweed powder is used in an amount that is 2 to 12% by mass in the tablet, and it is more preferable that the petrified seaweed powder is used in an amount that is 3 to 12% by mass in the tablet. The amount of the petrified seaweed powder in the tablet is rounded off to the first decimal place.

[0054] The improvement in the physical properties of the tablet is not particularly limited and can be appropriately selected depending on the purpose, but it is preferable to improve at least one of the tablet hardness and the tablet disintegration property, and it is more preferable to improve the tablet hardness and the tablet disintegration property.

[0055] (Method for improving tablet properties) The method for improving the physical properties of a tablet of the present invention is a method for improving the physical properties of a tablet containing an ingredient having an angle of repose of 60° or more, and includes at least a blending step, and may further include other steps as necessary.

[0056] <Blending process> The blending step in the method for improving tablet physical properties is a step of blending the tablet physical property improving agent of the present invention into a composition for tableting. The blending step in the method for improving the physical properties of a tablet can be carried out in the same manner as the <<mixing step>> described in the section (Tablet manufacturing method) of the present invention above.

[0057] <Other processes> The other steps in the method for improving the physical properties of a tablet are not particularly limited and can be appropriately selected depending on the purpose as long as they do not impair the effects of the present invention. For example, the other steps include the <tabletting step> described in the above section (Tablet manufacturing method) of the present invention.

[0058] According to the tablet physical property improving agent and tablet physical property improving method of the present invention, by blending a tablet physical property improving agent containing at least a powder of petrified seaweed with a component having an angle of repose of 60° or more, it is possible to improve at least one of tablet hardness and tablet disintegration property. In addition, it is also possible to achieve a good balance between tablet disintegration time and hardness.

[0059] (Filling improver) The filling property improving agent of the present invention is intended to improve the filling property of a tableting composition containing a component with an angle of repose of 60° or more into the dies of a tablet press, and contains at least petrified seaweed powder, and further contains other components as necessary. The components having a repose angle of 60° or more, the petrified seaweed powder, and other components in the filling property improvement agent are respectively the same as the components having a repose angle of 60° or more, the petrified seaweed powder, and other components in the tablets described in the (tablet) section of the present invention above, and the preferred aspects are also the same.

[0060] The amount of the filling improvement agent used is not particularly limited, and can be appropriately selected depending on the purpose, so long as the petrified seaweed powder is blended in an amount of 2 to 20% by mass in the tableting composition; however, it is preferable that the petrified seaweed powder is blended in an amount of 2 to 12% by mass in the tableting composition, and it is more preferable that the petrified seaweed powder is blended in an amount of 3 to 12% by mass. The amount of the petrified seaweed powder in the composition for tableting is rounded off to the first decimal place.

[0061] (Method for improving filling properties) The method for improving filling property of the present invention is a method for improving the filling property of a tableting composition containing a component having an angle of repose of 60° or more into the dies of a tablet press, and includes at least a blending step, and may further include other steps as necessary.

[0062] <Blending process> The blending step in the method for improving filling property is a step of blending the filling property improver of the present invention into a composition for tableting. The blending step in the method for improving filling property can be carried out in the same manner as the <<mixing step>> described in the section (Tablet manufacturing method) of the present invention above.

[0063] <Other processes> The other steps in the filling property improvement method are not particularly limited as long as they do not impair the effects of the present invention, and can be appropriately selected depending on the purpose. For example, there can be mentioned the <tabletting step> described in the above section of the present invention (tablet manufacturing method).

[0064] According to the filling property improvement method of the present invention, by blending a filling property improvement agent containing at least petrified seaweed powder with a component having an angle of repose of 60° or more, the filling property of the tableting composition into the dies of a tablet press can be improved, and the tableting suitability can be improved. EXAMPLES

[0065] The present invention will be specifically explained below by way of test examples, but the present invention is not limited to these test examples.

[0066] (Test Example 1) - Preparation of tablet powder - As an example of a component with an angle of repose of 60° or more, dried yeast (product name "Dried Brewer's Yeast YT", manufactured by Asahi Group Foods Co., Ltd., dynamic angle of repose 62.5°) was used and mixed with each of the raw materials listed in Tables 1 to 2 below (total of 100 parts by mass) and 0.6 parts by mass of calcium stearate to form each tablet powder. The details of the components used are as follows: Petrified seaweed powder (product name: Aqua Mineral T, manufactured by Japan Biocon Co., Ltd.) Calcium carbonate A (product name: CoroCalso-EX, manufactured by Shiraishi Kogyo Co., Ltd.) Calcium carbonate B (product name: "Scallop powder", manufactured by NC Corporation) Calcium carbonate C (product name "Cal Essen-P", manufactured by Shiraishi Kogyo Co., Ltd.) Dolomite (product name: "Dolomite", manufactured by NC Corporation)

[0067] -Tableting- Using a single punch tablet press (AUTOTAB-200, manufactured by Ichihashi Seiki Co., Ltd.), the tablet powder was packed and compressed at a pressure (tabletting pressure) of 15 kN, 20 kN, or 25 kN to produce tablets with a diameter of 10 mm, a radius of curvature (R) of 8.5 mm, and a weight of 400 mg per tablet.

[0068] <Evaluation> [Tablet hardness] The hardness (N) of the produced tablets was measured using a fully automatic tablet measuring machine Multicheck5.1 (manufactured by ERWEKA) and evaluated according to the following evaluation criteria. The results are shown in Table 3. -Evaluation criteria- ○: A hardness of 40N or more is achieved with a maximum tableting pressure of 25kN. △: At a tableting pressure of up to 25 kN, the hardness is between 31 N and 40 N. ×: Hardness of 31N or more cannot be achieved with a tableting pressure of up to 25kN. -: Evaluation is not possible because tablets cannot be pressed using a single-shot tablet press (the powder is not fully filled into the die even after the powder shooter goes back and forth nine times).

[0069] [Balance between disintegration time and tablet hardness] The disintegration time of the produced tablets was measured using a fully automatic disintegration tester ZT322 (manufactured by ERWEKA) with water as the solvent and a water temperature of 37°C (with an auxiliary plate). The balance between the disintegration time and the tablet hardness was evaluated according to the following evaluation criteria. The results are shown in the column for evaluation of the disintegration time item in Table 3. -Evaluation criteria- ○: When tablet hardness and disintegration time are plotted on a scatter diagram and connected with a straight line, the hardness at which the disintegration time is 6 minutes 30 seconds is 40N or more. Or, the disintegration time is less than 6 minutes 30 seconds when the tablet hardness is 40N or more. △: When tablet hardness and disintegration time are plotted on a scatter diagram and connected with a straight line, the hardness at the point where the disintegration time is 6 minutes 30 seconds is 30 N or more and less than 40 N. Or, when the tablet hardness is 30 N or more and less than 40 N, the disintegration time is less than 6 minutes 30 seconds, and does not meet the above evaluation criteria for ○. ×: When tablet hardness and disintegration time are plotted on a scatter diagram and connected with a straight line, the hardness at the point where the disintegration time is 6 minutes 30 seconds is less than 30 N. Or, the tablet hardness at a tableting pressure of 25 kN is less than 30 N. -: Evaluation is not possible because tablets cannot be pressed using a single-shot tablet press (the powder is not fully filled into the die even after the powder shooter goes back and forth nine times).

[0070] [Filling ability of the composition for tableting into the die of the tablet press] The tableting compositions were evaluated for their ability to be filled into the die of a tablet press according to the following criteria. The results are shown in Table 4. -Evaluation criteria- ○: When using a single-shot tablet press and tableting at a pressure of 25 kN, the powder shooter must reciprocate six or fewer times before the tablet powder is completely filled into the die. △: When using a single-shot tablet press and tableting at a pressure of 25 kN, the powder shooter reciprocated 7 to 9 times before the tablet powder was completely filled into the die. ×: When using a single-shot tablet press and tableting at a pressure of 25 kN, tablets could not be produced (the tablet powder was not completely filled into the die even after the powder shooter went back and forth nine times).

[0071] [Table 1]

[0072] [Table 2]

[0073] [Table 3]

[0074] [Table 4]

[0075] (Test Example 2) - Preparation of tablet powder - As an example of an ingredient with an angle of repose of 60° or more, whey protein (product name "Wheyco W80", manufactured by wheyco GmbH, dynamic angle of repose 71°) was used and mixed with each of the raw materials listed in Tables 5 to 6 below (total of 100 parts by mass) and 1.0 part by mass of calcium stearate to obtain each tablet powder. The details of the components used are as follows: Petrified seaweed powder (product name: Aqua Mineral T, manufactured by Japan Biocon Co., Ltd.) Calcium carbonate B (product name: "Scallop powder", manufactured by NC Corporation) Calcium carbonate C (product name "Cal Essen-P", manufactured by Shiraishi Kogyo Co., Ltd.)

[0076] -Tableting- Tablets were produced in the same manner as in Test Example 1, except that the above-mentioned tableting powder was used and the tableting pressure was 10 kN or 20 kN.

[0077] <Evaluation> [Tablet hardness] The hardness (N) of the produced tablets was measured using a fully automatic tablet measuring machine Multicheck5.1 (manufactured by ERWEKA) and evaluated according to the following evaluation criteria. The results are shown in Table 7. -Evaluation criteria- ○: At a tableting pressure of 10 kN, a hardness of 70 N or more is achieved. ×: A hardness of 70N or more was not achieved at a tableting pressure of 10 kN. -: Evaluation is not possible because tablets cannot be pressed using a single-shot tablet press (the powder is not fully filled into the die even after the powder shooter goes back and forth nine times).

[0078] [Balance between disintegration time and tablet hardness] The disintegration time of the produced tablets was measured using a fully automatic disintegration tester ZT322 (manufactured by ERWEKA) with water as the solvent and a water temperature of 37°C (with an auxiliary plate). The balance between the disintegration time and the tablet hardness was evaluated according to the following evaluation criteria. The results are shown in the column for evaluation of the disintegration time item in Table 7. -Evaluation criteria- ○: When tablet hardness and disintegration time are plotted on a scatter diagram and connected by a straight line, the hardness at the point where the disintegration time is 37 minutes is 100 N or more. If there is no point where the disintegration time is 37 minutes, the hardness was judged by the point where the extension of the straight line intersects with 37 minutes. △: When tablet hardness and disintegration time are plotted on a scatter diagram and connected by a straight line, the hardness at the point where the disintegration time is 37 minutes is 80 N or more and less than 100 N. If there is no point where the disintegration time is 37 minutes, the hardness was judged by the point where the extension of the straight line intersects with 37 minutes. ×: When tablet hardness and disintegration time were plotted on a scatter diagram and connected by a straight line, the hardness at the point where the disintegration time was 37 minutes was less than 80 N. If there was no point where the disintegration time was 37 minutes, the hardness was judged by the point where the extension of the straight line intersected with 37 minutes. -: Evaluation is not possible because tablets cannot be pressed using a single-shot tablet press (the powder is not fully filled into the die even after the powder shooter goes back and forth nine times).

[0079] [Filling ability of the composition for tableting into the die of the tablet press] The tableting compositions were evaluated for their ability to be filled into the die of a tablet press according to the following criteria. The results are shown in Table 8. -Evaluation criteria- ○: When using a single-shot tablet press and tableting at a pressure of 20 kN, the powder shooter must reciprocate six or fewer times before the tablet powder is completely filled into the die. △: When using a single-shot tablet press and tableting at a pressure of 20 kN, the powder shooter reciprocated 7 to 9 times before the tablet powder was completely filled into the die. ×: When using a single-shot tablet press and tableting at a pressure of 20 kN, tablets could not be produced (the tablet powder was not completely filled into the die even after the powder shooter went back and forth nine times).

[0080] [Table 5]

[0081] [Table 6]

[0082] [Table 7]

[0083] [Table 8]

[0084] As described above, according to the present invention, it was confirmed that the use of petrified seaweed powder can improve the filling property of a tableting composition containing a component with an angle of repose of 60° or more into the die of a tablet press. It was also confirmed that the physical properties of the tablet can be improved, for example, the tablet hardness and disintegration property can be improved, and a tablet with a good balance between disintegration time and hardness can be obtained.

Claims

1. A tablet physical property improver for improving the physical properties of a tablet containing a component having an angle of repose of 60° or more, Contains petrified seaweed powder, The tablet physical property improving agent is characterized in that the petrified seaweed powder is blended in an amount of 2 to 20% by mass in the tablet.

2. The tablet physical property improving agent according to claim 1, wherein the improvement in the tablet physical property is at least one of an improvement in tablet hardness and an improvement in tablet disintegrability.

3. A method for improving the physical properties of a tablet containing a component having an angle of repose of 60° or more, comprising: A method for improving tablet physical properties, comprising blending the tablet physical property improver according to claim 1 or 2 into a tableting composition.

4. A filling property improver for improving the filling property of a tableting composition containing a component having an angle of repose of 60° or more into a die of a tablet press, comprising: Contains petrified seaweed powder, The filling property improving agent is characterized in that the petrified seaweed powder is blended in the tableting composition in an amount of 2 to 20% by mass.

5. A method for improving the filling property of a tableting composition containing a component having an angle of repose of 60° or more into a die of a tablet press, comprising: A method for improving filling properties, comprising blending the filling property improver according to claim 4 into the tableting composition.

6. The present invention comprises a component having an angle of repose of 60° or more and a powder of petrified seaweed, A tablet characterized in that the content of the petrified seaweed powder in the tablet is 2 to 20 mass%.

7. The method includes tableting a composition for tableting, the composition comprising a component having an angle of repose of 60° or more and a powder of petrified seaweed, A method for producing tablets, characterized in that the content of the petrified seaweed powder in the tableting composition is 2 to 20 mass%.

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