Emulsified composition for external use and method for producing the same

Abstract

To provide an emulsified composition for external use having excellent stability and sense of use.SOLUTION: There is prepared an emulsified composition for external use comprising (A) a water-soluble ascorbic acid derivative; (B) a cellulose nanofiber; (C) an ultraviolet absorber; and (D) a thickener. The emulsified composition for external use can more effectively exhibit a function possessed by the water-soluble ascorbic acid derivative and a function possessed by the ultraviolet absorber. A user can apply the emulsified composition for external use evenly to the application area due to its good applicability, and the emulsified composition for external use can maintain the skin care function and UV absorbing ability of the water-soluble ascorbic acid derivative for a long time due to the high adhesiveness to the application area. Since the emulsified composition for external use can be applied uniformly, when a makeup product is applied over the emulsified composition for external use, the makeup product can be applied uniformly, enhancing the makeup effect and providing a good aesthetic appearance. The emulsified composition for external use can maintain uniform adhesion for a long time even if the application area is moved by daily activities because of its high adhesiveness to the application area. A makeup product applied on top of the emulsified composition for external use also maintains uniform adhesion even during various activities of daily life, thus enabling to maintain good makeup effects for a long period of time.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to an emulsified composition for topical use, and more particularly to an emulsified composition for topical use containing an ultraviolet absorbent and a water-soluble ascorbic acid derivative. [Background technology]

[0002] There are three types of ultraviolet rays: ultraviolet A (UV-A), ultraviolet B (UV-B), and others. Of these, UV-A has a long wavelength and penetrates deep into the skin, causing effects such as denaturing collagen, and it has been found to be closely related to the development of age spots and wrinkles.

[0003] UV-B has a short wavelength and is blocked by the ozone layer and clouds compared to UV-A, so only about 10% of the total UV rays reach the earth. However, UV-B has high energy and can damage cells on the surface of the skin and cause inflammation.

[0004] As the effects of ultraviolet light on the skin have become clearer, there has been an increasing demand for topical compositions containing ultraviolet absorbents, and various topical compositions have been proposed (Patent Document 1). [Prior art documents] [Patent documents]

[0005] [Patent Document 1] JP 2015-17080 A Summary of the Invention [Problem to be solved by the invention]

[0006] While it is preferable to have a water-soluble ascorbic acid derivative coexist in an emulsified topical composition containing an ultraviolet absorber in order to impart many functions to the composition, the incorporation of the water-soluble ascorbic acid derivative can cause the emulsion to become non-uniform, making it difficult to impart stability.

[0007] The present invention aims to provide an emulsified composition for external use containing an ultraviolet absorber and a water-soluble ascorbic acid derivative, which has good stability, usability, and / or water resistance of ultraviolet absorbing ability. [Means for solving the problem]

[0008] As a result of intensive research by the present inventors to solve this problem, (A) Water-soluble ascorbic acid derivatives; (B) Cellulose nanofibers; (C) an ultraviolet absorber; and (D) Thickener The present invention has been completed based on the discovery that by preparing an emulsified topical composition containing the above, a composition excellent in stability, usability, and / or water resistance of ultraviolet absorbing ability can be obtained.

[0009] That is, the present invention provides the emulsified topical compositions described below. Item 1(A) Water-soluble ascorbic acid derivatives; (B) Cellulose nanofibers; (C) an ultraviolet absorber; and (D) Thickener An emulsified topical composition comprising: Item 2. The emulsified composition for external use according to Item 1, wherein the content of the component (A) is 0.1 to 7.0% by mass or more. Item 3. The emulsified composition for external use according to Item 1 or 2, wherein the content of the component (B) is 0.01 to 1.5% by mass or more. Item 4. The emulsified composition for external use according to any one of Items 1 to 3, wherein the content of the component (D) is 0.1 to 1.0% by mass or more. Item 5. The emulsified composition for external use according to any one of Items 1 to 4, wherein the content of the component (C) is 4.5 to 18.0% by mass or more. Item 6. The emulsified composition for external use according to any one of Items 1 to 5, comprising 0.1 to 10.0 parts by mass of component (D) per 1 part by mass of component (B). Item 7. The emulsified composition for external use according to any one of items 1 to 6, further comprising a surfactant. Item 8. The emulsified composition for external use according to any one of Items 1 to 7, wherein the component (D) is at least one selected from the group consisting of acrylic thickeners, vinyl thickeners such as polyvinyl alcohol, polyvinylpyrrolidone, and carboxyvinyl polymers, and acidic mucopolysaccharides such as alginic acid, chondroitin sulfate, and salts thereof. Item 9. A method for improving the storage stability of an emulsified composition for external use by allowing a composition containing (A) a water-soluble ascorbic acid derivative; (C) an ultraviolet absorber; and (D) a thickener to contain (B) cellulose nanofibers. Item 10. A method for improving ultraviolet protection ability by allowing a composition containing (A) a water-soluble ascorbic acid derivative; (C) an ultraviolet absorber; and (D) a thickener to coexist with (B) cellulose nanofibers. Effect of the Invention

[0010] The present invention can provide an emulsified composition for external use that is excellent in usability and stability. [Brief description of the drawings]

[0011] [Figure 1] FIG. 13 is a diagram showing some of the evaluation results of Test Example 2. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0012] In this specification, the unit of content "mass%" is synonymous with "g / 100 g".

[0013] Although it is very useful to make water-soluble ascorbic acid derivative coexist with ultraviolet absorber in composition to give multifunctionality, when water-soluble ascorbic acid derivative is contained in emulsion composition for external use, composition becomes unstable, and further, it may have a bad influence on feeling of use.It is particularly difficult to obtain emulsion composition for external use that contains water-soluble ascorbic acid derivative and ultraviolet absorber and has good stability and feeling of use at the same time.

[0014] The emulsion composition for topical use of the present invention comprises: (A) Water-soluble ascorbic acid derivatives; (B) Cellulose nanofibers; (C) an ultraviolet absorber; and (D) Thickener It is an emulsified composition for external use containing the above.

[0015] [(A) Water-soluble ascorbic acid derivative] The water-soluble ascorbic acid derivative contained in the emulsified composition for external use of the present invention is not particularly limited as long as it is used as an ingredient of medicines, quasi-drugs, or cosmetics. The ingredient is preferably pharmaceutical or physiologically acceptable when applied to the skin. The water-soluble ascorbic acid derivative can be used as one type of compound alone or two or more types of compounds in combination. Those synthesized by known methods may be used, and can also be obtained as commercial products. Water-soluble means that 10 g or more of the ingredient dissolves in 100 g of water.

[0016] Specifically, examples of water-soluble ascorbic acid derivatives include L-ascorbic acid monoesters such as L-ascorbic acid 2-glucoside, 3-O-ethyl ascorbic acid, glyceryl ascorbic acid, 3-glyceryl ascorbic acid, bisglyceryl ascorbic acid, L-ascorbic acid 2-phosphate, L-ascorbic acid 3-phosphate, L-ascorbic acid 6-phosphate, L-ascorbic acid 2-polyphosphate, and L-ascorbic acid 2-sulfate.

[0017] Examples of salts of water-soluble ascorbic acid derivatives include sodium salts, potassium salts, magnesium salts, calcium salts, barium salts, ammonium salts, monoethanolamine salts, diethanolamine salts, triethanolamine salts, monoisopropanolamine salts, and triisopropanolamine salts.

[0018] Among these, it is preferable to use L-ascorbic acid 2-glucoside, 3-O-ethyl ascorbic acid, L-ascorbic acid 2-phosphate magnesium salt, and L-ascorbic acid 2-phosphate sodium salt, and it is particularly preferable to use L-ascorbic acid 2-glucoside, 3-O-ethyl ascorbic acid, and L-ascorbic acid 2-phosphate magnesium salt.

[0019] In the emulsion topical composition of the present invention, the total content of component (A) relative to the total amount of the emulsion topical composition is appropriately set depending on the type of component (A), the types and contents of other blended components, the application and formulation form of the emulsion topical composition, etc. From the viewpoint of maintaining a good feeling in use, the total content of component (A) relative to the total amount of the emulsion topical composition is preferably 0.1% by mass to 7.0% by mass, more preferably 0.5% by mass to 5.0% by mass, and even more preferably 1.0% by mass to 3.0% by mass.

[0020] [(B) Cellulose nanofiber] The cellulose nanofiber contained in the emulsified topical composition of the present invention is not particularly limited as long as it is used as an ingredient of a medicine, a quasi-drug, or a cosmetic. The ingredient is preferably pharma- ceutical or physiologically acceptable when applied to the skin. The cellulose nanofiber is a fiber obtained by finely pulverizing cellulose fibers to nano size. The cellulose nanofiber can be used alone or in combination of two or more types. Here, the combination of two or more types means the combination of types with different average fiber diameters or types containing different moieties.

[0021] The number average fiber diameter of the cellulose nanofibers used in the emulsified topical composition of the present invention is about 0.1 to 500 nm, preferably about 0.6 to 200 nm, and more preferably about 1 to 150 nm. The maximum fiber diameter of the cellulose nanofibers is preferably 1000 nm or less. The number average fiber diameter and maximum fiber diameter of the cellulose nanofibers can be measured by known methods. For example, they can be measured using a transmission electron microscope (TEM), a scanning electron microscope (SEM), an atomic force microscope (AFM), or the like.

[0022] The average aspect ratio of the cellulose nanofibers used in the emulsified composition for external use of the present invention is not limited, but is about 10-10,000, and preferably about 20-1,000.

[0023] The cellulose nanofibers are preferably fibers obtained by micronizing a cellulose raw material having a crystalline structure.

[0024] The cellulose nanofibers preferably contain anionic functional groups such as carboxyl groups, carboxymethyl groups, phosphate groups, phosphonium groups, sulfonium groups, etc. The cellulose nanofibers more preferably contain carboxymethyl groups, carboxy groups, and phosphate groups.

[0025] The cellulose nanofiber may be a commercially available product, including, but not limited to, Leocrysta C-2SP (manufactured by Daiichi Kogyo Seiyaku Co., Ltd.), Aurovisco CS (manufactured by Oji Holdings Co., Ltd.), and Cellenpia CS-01C (manufactured by Nippon Paper Industries Co., Ltd.).

[0026] In the emulsion topical composition of the present invention, the content of the (B) component relative to the total amount of the emulsion topical composition (dry weight at 100% purity) is appropriately set depending on the type of the (B) component, the types and contents of other blended components, the use of the emulsion topical composition, the formulation form, etc. From the viewpoint of exerting an ultraviolet absorbing effect and maintaining a good feeling of use, the content of the (B) component relative to the total amount of the emulsion topical composition is preferably 0.01% by mass to 1.50% by mass, more preferably 0.05% by mass to 0.60% by mass, even more preferably 0.07% by mass to 0.40% by mass, and even more preferably 0.10% by mass to 0.30% by mass.

[0027] In the emulsified topical composition of the present invention, the ratio of the total content of the (B) component to the total content of the (A) component is not particularly limited, but is preferably 1.0 to 25.0 parts by mass, more preferably 3.0 to 20.0 parts by mass, and even more preferably 7.0 to 15.0 parts by mass, per 1 part by mass of the total content of the (B) component.

[0028] [(C) Ultraviolet absorber] The ultraviolet absorbing agent contained in the emulsified composition for external use of the present invention is not particularly limited as long as it is used as an ingredient of medicines, quasi-drugs or cosmetics. It is preferable that the ingredient is pharmaceutical or physiologically acceptable when applied to the skin. The ultraviolet absorbing agent can be used as one type of compound alone or two or more types of compounds in combination.

[0029] The ultraviolet absorbent may be a liquid ultraviolet absorbent at 25° C. or a solid ultraviolet absorbent at 25° C. From the viewpoint of achieving the effects of the present invention, it is preferable to use a liquid ultraviolet absorbent and a solid ultraviolet absorbent in combination.

[0030] The ultraviolet absorber may preferably be a salicylic acid-based ultraviolet absorber, a cinnamic acid-based ultraviolet absorber, a benzoylmethane-based ultraviolet absorber, a benzoic acid ester derivative ultraviolet absorber, a triazine derivative ultraviolet absorber, a benzalmalonate derivative ultraviolet absorber, an octocrylene-based ultraviolet absorber, an imidazole sulfonic acid derivative ultraviolet absorber, a benzophenone derivative ultraviolet absorber, or the like.

[0031] In detail, examples of the ultraviolet absorbing agent include salicylic acid-based ultraviolet absorbing agents such as 2-ethylhexyl salicylate, homomenthyl salicylate, and ethylene glycol salicylate; cinnamic acid-based ultraviolet absorbing agents such as glyceryl di-paramethoxycinnamate mono-2-ethylhexanoate, ethyl paradihydroxypropylbenzoate, and 2-ethylhexyl paramethoxycinnamate; and benzoylmethane-based ultraviolet absorbing agents such as 4-tert-butyl-4'-methoxydibenzoylmethane. Agents;2-[4-(diethylamino)-2-hydroxybenzoyl]benzoic acid hexyl ester and other benzoic acid ester derivatives UV absorbers;Dimethoxybenzylidene dioxoimidazolidinepropionic acid 2-ethylhexyl;2,2'-methylenebis[6-(2H-benzotriazol-2yl)-4-(1,1,3,3-tetramethylbutyl)phenol];2,4-bis-[{4-(2-ethylhexyloxy)-2-hydroxy}-phenyl]- triazine derivatives such as 6-(4-methoxyphenyl)-1,3,5-triazine, diethylhexylbutamidotriazone, and 2,4,6-tris[4-(2-ethylhexyloxycarbonyl)anilino]-1,3,5-triazine; benzalmalonate derivative ultraviolet absorbers such as dimethicodiethylbenzalmalonate; octocrylene-based ultraviolet absorbers such as 2-cyano-3,3-diphenylprop-2-enoic acid 2-ethylhexyl ester; imidazole sulfonic acid derivative ultraviolet absorbers such as 2-phenylbenzimidazole-5-sulfonic acid and disodium phenyldibenzimidazole tetrasulfonate; and benzophenone derivative ultraviolet absorbers such as 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid and salts thereof, dihydroxydimethoxybenzophenone, dihydroxybenzophenone, and tetrahydroxybenzophenone.

[0032] In the present invention, such ultraviolet absorbers are not limited to, but include 2-ethylhexyl paramethoxycinnamate, 4-tert-butyl-4'-methoxydibenzoylmethane, 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoic acid hexyl ester, dimethoxybenzylidene dioxoimidazolidinepropionate 2-ethylhexyl, 2,2'-methylenebis[6-(2H-benzotriazol-2yl)-4-(1,1,3,3-tetramethylbutyl) Phenol], 2,4-bis-[{4-(2-ethylhexyloxy)-2-hydroxy}-phenyl]-6-(4-methoxyphenyl)-1,3,5-triazine, 2,4,6-tris[4-(2-ethylhexyloxycarbonyl)anilino]-1,3,5-triazine, dimethicodimethyi benzalmalonate, 2-cyano-3,3-diphenylprop-2-enoic acid 2-ethylhexyl ester, or 2-phenylbenzimidazole-5-sulfonic acid are preferred, and para- 2-Ethylhexyl toxiccinnamate, 4-tert-butyl-4'-methoxydibenzoylmethane, 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoic acid hexyl ester, 2,4-bis-[{4-(2-ethylhexyloxy)-2-hydroxy}-phenyl]-6-(4-methoxyphenyl)-1,3,5-triazine, 2,4,6-tris[4-(2-ethylhexyloxycarbonyl)anilino]-1,3,5-triazine, or 2-phenylbenzo Imidazole-5-sulfonic acid is more preferred, and 2-ethylhexyl paramethoxycinnamate, 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoic acid hexyl ester, 2,4-bis-[{4-(2-ethylhexyloxy)-2-hydroxy}-phenyl]-6-(4-methoxyphenyl)-1,3,5-triazine, and / or 2,4,6-tris[4-(2-ethylhexyloxycarbonyl)anilino]-1,3,5-triazine are even more preferred.

[0033] Specific examples of the solid ultraviolet absorber preferably include 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoic acid hexyl ester, 2,4-bis-[{4-(2-ethylhexyloxy)-2-hydroxy}-phenyl]-6-(4-methoxyphenyl)-1,3,5-triazine, and 2,4,6-tris[4-(2-ethylhexyloxycarbonyl)anilino]-1,3,5-triazine. , 2,2'-methylenebis[6-(2H-benzotriazole-2yl)-4-(1,1,3,3-tetramethylbutyl)phenol]), terephthalidene discamphor sulfonic acid, terephthalidene dicamphor sulfonic acid, drometrizole trisiloxane, phenylbenzimidazole sulfonic acid, t-butyl methoxydibenzoylmethane, dimethoxybenzylidene dioxoimidazolidine propionate 2-ethylhexyl, dihydroxydimethoxybenzophenone disulfonate sodium, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-meth At least one selected from the group consisting of oxybenzophenone-5-sulfonic acid and its salts, dihydroxydimethoxybenzophenone, dihydroxybenzophenone, tetrahydroxybenzophenone (oxybenzone-2), dihydroxybenzophenone, ferulic acid, trisbiphenyltriazine, di-paramethoxycinnamate mono-2-ethylhexanoate glyceryl, para-aminobenzoic acid (hereinafter abbreviated as "PABA") or its derivatives (ethyl PABA, ethyl-dihydroxypropyl PABA, ethylhexyl-dimethyl PABA, glyceryl PABA, etc.), More preferably, it is at least one selected from the group consisting of 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoic acid hexyl ester, 2,4-bis-[{4-(2-ethylhexyloxy)-2-hydroxy}-phenyl]-6-(4-methoxyphenyl)-1,3,5-triazine, and 2,4,6-tris[4-(2-ethylhexyloxycarbonyl)anilino]-1,3,5-triazine.

[0034] The ultraviolet absorbing agent may be a commercially available product or may be synthesized.

[0035] Commercially available products include, but are not limited to, Parsol EHS (manufactured by DSM Nutrition Japan), ESCALOL 587 (manufactured by Ashland Japan), EusolexOS (manufactured by Merk), Parsol HMS (manufactured by DSM Nutrition Japan), Uvinul MC80 (manufactured by BASF), Parsol MCX (manufactured by DSM Nutrition Japan), Parsol 1789 (manufactured by DSM Nutrition Japan), Uvinul A Plus Granular, Soft Shade DH, Tinosorb M (manufactured by BASF), Milestab 360 (manufactured by MPI), Mixxim BB / 100, Tinosorb S (manufactured by BASF), Uvasorb HEB, Uvinul T150 (manufactured by BASF), Heliosun OTZ (manufactured by O'Laughlin Industries), Parsol SLX (manufactured by DSM Nutrition Japan), Parsol 340 (manufactured by DSM Nutrition Japan), Escarol 597 (manufactured by Ashland Japan), Parsol HS (manufactured by DSM Nutrition Japan), Eusolex 232 (manufactured by Merk), NeoHeliopan AP (manufactured by Herman & Reimer), Ubinal M40, Escarol 567 (manufactured by Ashland Japan), Ubinal MS40 (manufactured by BASF), EESORB 107 (manufactured by Cipro Chemicals), SEESORB 100 (manufactured by Cipro Chemicals), and SEESORB 106 (manufactured by Cipro Chemicals).

[0036] In the emulsion topical composition of the present invention, the total content of the (C) component relative to the total amount of the emulsion topical composition is appropriately set according to the type of the (C) component, the types and contents of other blended components, the use of the emulsion topical composition, the formulation form, etc. From the viewpoint of exerting an ultraviolet absorbing effect and maintaining a good feeling of use, the total content of the (C) component relative to the total amount of the emulsion topical composition is preferably 4.5% by mass to 18.0% by mass, more preferably 5.0% by mass to 17.0% by mass, and even more preferably 8.0% by mass to 16.0% by mass.

[0037] The total content of the liquid ultraviolet absorbent relative to the total amount of the emulsified composition for external use is preferably 1.0% by mass to 15.0% by mass, more preferably 2.0% by mass to 12.0% by mass, and even more preferably 3.0% by mass to 10.0% by mass. The total content of the solid ultraviolet absorbent relative to the total amount of the emulsified composition for external use is preferably 0.1% by mass to 10.0% by mass, more preferably 0.5% by mass to 8.0% by mass, and even more preferably 1.5% by mass to 8.0% by mass.

[0038] In the emulsified topical composition of the present invention, the ratio of the total content of the (B) component to the total content of the (C) component is not particularly limited, but is preferably 30 parts by mass to 160 parts by mass, more preferably 40 parts by mass to 160 parts by mass, and even more preferably 50 parts by mass to 150 parts by mass, per 1 part by mass of the total content of the (B) component.

[0039] [(D) Thickener] The thickener contained in the emulsified topical composition of the present invention is not particularly limited as long as it is used as an ingredient of medicines, quasi-drugs or cosmetics. It is preferable that the ingredient is pharmaceutical or physiologically acceptable when applied to the skin. It may be synthesized by a known method, and it may be available as a commercial product. The thickener may be used as one type of compound alone, or two or more types of compounds in combination.

[0040] Examples of thickeners include acrylic thickeners, vinyl thickeners, cellulose thickeners excluding cellulose nanofibers, acidic mucopolysaccharides, and branched polysaccharides.

[0041] In the present invention, such thickeners are not limited, but are preferably acrylic thickeners; vinyl thickeners; cellulose thickeners other than cellulose nanofibers; and acidic mucopolysaccharides. Acrylic thickeners such as acrylic acid alkyl methacrylate copolymer, hydroxyethyl acrylate-sodium acryloyldimethyl taurate copolymer, sodium acrylate-acryloyldimethyl taurate copolymer, ammonium polyacrylate, sodium acrylate-sodium acryloyldimethyl taurate copolymer, polyacrylic acid amide, acrylamide-sodium acryloyldimethyl taurate copolymer, acrylamide-ammonium acrylate copolymer; vinyl thickeners such as polyvinyl alcohol, polyvinylpyrrolidone, carboxyvinyl polymer; acidic mucopolysaccharides such as alginic acid, chondroitin sulfate and salts thereof are more preferred, Hydroxyethyl acrylate-sodium acryloyldimethyl taurate copolymer, polyacrylamide, sodium acrylate-sodium acryloyldimethyl taurate copolymer, ammonium polyacrylate, acrylamide-sodium acryloyldimethyl taurate copolymer, and acrylamide-ammonium acrylate copolymer are more preferred.

[0042] In the emulsion topical composition of the present invention, the total content of the (D) component relative to the total amount of the emulsion topical composition is appropriately set according to the type of the (D) component, the types and contents of other blended components, the use of the emulsion topical composition, the formulation form, etc. From the viewpoint of exerting an ultraviolet absorbing effect and maintaining a good feeling of use, the total content of the (D) component relative to the total amount of the emulsion topical composition may be preferably 0.1% by mass to 1.0% by mass, more preferably 0.2% by mass to 0.9% by mass, and even more preferably 0.3% by mass to 0.8% by mass.

[0043] Based on the total amount of the emulsified topical composition, typically, one or more selected from the group consisting of polyvinyl alcohol; polyvinylpyrrolidone; carboxyvinyl polymer; acrylic thickener; cellulose thickener; alginic acid; and sodium chondroitin sulfate may be present in an amount of preferably 0.1% by mass to 1.0% by mass, more preferably 0.2% by mass to 0.9% by mass, and even more preferably 0.3% by mass to 0.8% by mass.

[0044] In the emulsified topical composition of the present invention, the ratio of the total content of the (D) component to the total content of the (A) component is not particularly limited, but is preferably 0.05 parts by mass to 5.0 parts by mass, more preferably 0.05 parts by mass to 3.0 parts by mass, even more preferably 0.1 parts by mass to 2.0 parts by mass, even more preferably 0.1 parts by mass to 1.0 parts by mass, and most preferably 0.1 parts by mass to 0.7 parts by mass, per 1 part by mass of the total content of the (A) component.

[0045] In the emulsified topical composition of the present invention, the ratio of the total content of the (D) component to the total content of the (B) component is not particularly limited, but from the viewpoint of achieving the effects of the present invention, it is preferably 0.1 to 10.0 parts by mass, more preferably 0.5 to 8.0 parts by mass, and even more preferably 1.0 to 6.0 parts by mass per 1 part by mass of the total content of the (B) component.

[0046] [Surfactants] The emulsion topical composition of the present invention may contain a surfactant in addition to the above-mentioned components (A), (B), (C), and (D) from the viewpoint of improving the feeling of use, improving stability, etc., as long as the effects of the present invention are not hindered. The surfactant contained in the emulsion topical composition of the present invention is not particularly limited as long as it is used as an ingredient of medicines, quasi-drugs, or cosmetics.

[0047] The surfactant may be any of a nonionic surfactant, a cationic surfactant, an anionic surfactant, an amphoteric surfactant, etc. Among these, although not limited thereto, a nonionic surfactant, an anionic surfactant, or an amphoteric surfactant is preferred, and a nonionic surfactant or an anionic surfactant is more preferred.

[0048] Examples of nonionic surfactants include sorbitan fatty acid esters (e.g., sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, diglycerol sorbitan penta-2-ethylhexyl acid, diglycerol sorbitan tetra-2-ethylhexyl acid, etc.); propylene glycol fatty acid esters (e.g., propylene glycol monostearate, etc.); hydrogenated castor oil derivatives (e.g., For example, polyoxyethylene hydrogenated castor oil 40 (HCO-40), polyoxyethylene hydrogenated castor oil 50 (HCO-50), polyoxyethylene hydrogenated castor oil 60 (HCO-60), polyoxyethylene hydrogenated castor oil 80 (HCO-80), etc.; polyoxyethylene sorbitan fatty acid esters (for example, polyoxyethylene (20) sorbitan monolaurate (polysorbate 20), polyoxyethylene (20) sorbitan monostearate (polysorbate 60), polyoxyethylene monooleate, oxyethylene (20) sorbitan (polysorbate 80), polyoxyethylene (20) sorbitan isostearate, etc.); glycerin derivatives (e.g., polyoxyethylene monococonut oil glyceryl, glycerin alkyl ether); polyoxyalkylene alkyl ethers (e.g., polyoxyethylene cetyl ether, etc.); polyethylene glycol fatty acid esters such as polyethylene glycol monostearate (2E.0.), polyethylene glycol monostearate (4E.0.), polyethylene glycol monooleate (6E.0.); glycerin fatty acid esters such as decapolyglyceryl pentastearate, glyceryl monostearate, glyceryl monoisostearate, glyceryl monooleate, etc.; silicone surfactants (e.g., polyoxyethylene-methylpolysiloxane copolymer, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, PEG-9 polydimethylsiloxyethyl dimethicone, etc.); alkyl glucosides; and the like.

[0049] Examples of cationic surfactants include benzalkonium chloride, benzethonium chloride, and the like.

[0050] Examples of anionic surfactants include fatty acid soaps (e.g., sodium laurate, sodium palmitate, potassium laurate, potassium myristate, potassium palmitate, potassium stearate, etc.); alkyl sulfates (e.g., sodium lauryl sulfate, potassium lauryl sulfate, etc.); alkyl ether sulfates (e.g., POE-lauryl triethanolamine sulfate, sodium POE-lauryl sulfate, sodium laureth sulfate, etc.); N-acylsarcosinates (e.g., sodium lauroyl sarcosinate, etc.); higher fatty acid amide sulfonates (e.g., sodium N-myristoyl-N-methyl taurate, sodium coconut oil fatty acid methyl taurate, sodium lauryl methyl taurate, etc.); phosphates (sodium POE-oleyl ether phosphate, sodium POE-stearyl ether phosphate, sodium lauryl phosphate, polyoxyethylene lauryl Sodium ether phosphate, etc.; sulfosuccinates (e.g., sodium alkyl sulfosuccinate, sodium di-2-ethylhexyl sulfosuccinate, sodium polyoxyethylene sulfosuccinate, sodium lauryl polypropylene glycol sulfosuccinate, etc.); alkylbenzene sulfonates (e.g., sodium linear dodecylbenzene sulfonate, triethanolamine linear dodecylbenzene sulfonate, linear dodecylbenzene sulfonic acid, etc.); amino acid surfactants (e.g., sodium cocoyl glutamate, N-acyl glutamate, etc.); N-acyl glutamate (e.g., potassium lauroyl glutamate, monosodium N-lauroyl glutamate, disodium N-stearoyl glutamate, monosodium N-myristoyl-L-glutamate, etc.); higher fatty acid ester sulfates (e.g., hydrogenated coconut oil fatty acid glycerin sodium sulfate, um, etc.); sulfated oils (for example, turmeric oil, etc.); ether carboxylates (for example, polyoxyethylene alkyl ether carboxylic acids, polyoxyethylene alkyl allyl ether carboxylates, sodium polyoxyethylene lauryl ether acetate, etc.); α-olefin sulfonates; higher fatty acid ester sulfonates; secondary alcohol sulfates; higher fatty acid alkylolamide sulfates; sodium lauroyl monoethanolamide succinate; N-palmitoyl aspartic acid ditriethanolamine; sodium caseinate, and lactate fatty acid esters such as calcium stearoyl lactate and sodium stearoyl lactate.

[0051] Examples of amphoteric surfactants include glycine type surfactants such as alkyldiaminoethylglycine, acetate betaine type surfactants such as lauryldimethylaminoacetate betaine, imidazoline type surfactants, and phospholipid surfactants such as lecithin.

[0052] In the emulsified topical composition of the present invention, the total content of the surfactants relative to the total amount of the emulsified topical composition is appropriately set according to the type of surfactant, the type and content of other blended ingredients, the use and formulation form of the emulsified topical composition, etc., and is not particularly limited. The total content of the surfactants relative to the total amount of the emulsified topical composition is preferably 0.5% by mass to 5.0% by mass, more preferably 1.0% by mass to 4.0% by mass, and even more preferably 1.5% by mass to 3.0% by mass.

[0053] [water] The emulsified topical composition of the present invention may contain water in addition to the above-mentioned components (A), (B), (C), and (D) in order to improve the feeling of use and stability, as long as the effects of the present invention are not hindered. The total content of water relative to the total amount of the emulsified topical composition is appropriately set according to the type and content of other blended components, the use and formulation form of the emulsified topical composition, etc. From the viewpoint of obtaining a good feeling of use and stability, the content of water relative to the total amount of the emulsified topical composition is preferably 20.0% by mass to 80.0% by mass, more preferably 25.0% by mass to 78.0% by mass, even more preferably 30.0% by mass to 78.0% by mass, and most preferably 45.0% by mass to 75.0% by mass.

[0054] [Polyhydric alcohol] The emulsified topical composition of the present invention may contain a polyhydric alcohol in addition to the above-mentioned components (A), (B), (C), and (D) from the viewpoint of improving the feeling of use, stability, etc., as long as the effects of the present invention are not hindered. The polyhydric alcohol used in the present invention is not particularly limited as long as it is used, for example, as a component of a skin topical agent in the fields of medicines, quasi-drugs, or cosmetics. The polyhydric alcohol preferably has 2 to 10 carbon atoms, and examples thereof include polyethylene glycol, glycerin, diglycerin, triglycerin, propylene glycol, dipropylene glycol, 1,3-butanediol, ethylene glycol, diethylene glycol, isoprene glycol, 1,3-butylene glycol, sorbitol, xylitol, erythritol, mannitol, pentanediol, hexanediol, octanediol, decanediol, and neopentyl glycol.

[0055] From the viewpoint of maintaining good stability, the content of the polyhydric alcohol relative to the total amount of the emulsified topical composition is preferably 0.5% by mass to 15.0% by mass, more preferably 0.8% by mass to 12.0% by mass, even more preferably 1.0% by mass to 10.0% by mass, and even more preferably 2.0% by mass to 10.0% by mass.

[0056] [Base or carrier] The emulsified topical composition of the present invention may contain a base or carrier in addition to the above-mentioned components (A), (B), (C), and (D) from the viewpoint of improving the feeling of use, stability, etc., so long as the effects of the present invention are not hindered. Examples of the base or carrier include glycol ethers such as ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monopropyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monopropyl ether, diethylene glycol monobutyl ether, propylene glycol monoethyl ether, propylene glycol monopropyl ether, dipropylene glycol monoethyl ether, and dipropylene glycol monopropyl ether; lower alcohols such as ethanol and isopropanol; and the like.

[0057] Examples of the base or carrier include oily components, such as paraffin, ceresin, isoparaffin, hard fat, microcrystalline wax, polybutene, polyethylene powder, liquid paraffin, liquid isoparaffin, squalane, petrolatum, gelling hydrocarbons (such as plastibase), ozokerite, α-olefin oligomers, hydrocarbons such as light liquid paraffin and light liquid isoparaffin; isopropyl myristate, cetyl octanoate, octyldodecyl myristate, isopropyl palmitate, isopropyl isostearate, octyl palmitate, isopalmitate, isopalmite, isopropyl oleate ... Octyl acrylate, Butyl stearate, Hexyl laurate, Myristyl myristate, Decyl oleate, Isodecyl oleate, Hexyldecyl dimethyloctanoate, Diisopropyl sebacate, Di-2-ethylhexyl sebacate, 2-Hexyldecyl myristate, 2-Hexyldecyl palmitate, Diisopropyl adipate, 2-Hexyldecyl adipate, Isononyl isononanoate, Isotridecyl isononanoate, Cetyl lactate, Myristyl lactate, Lanolin acetate, Isocetyl stearate, Isocetyl isostearate, Iso Isostearyl stearate, cholesteryl 12-hydroxystearate, cholesteryl stearate, cholesteryl oleate, phytosteryl macadamiate, phytosteryl oleate, hydrogenated jojoba oil, ethylene glycol di-2-ethylhexylate, dipentaerythritol fatty acid ester, N-alkyl glycol monoisostearate, neopentyl glycol dicaprate, diisostearyl malate, glycerin di-2-heptylundecanoate, tri-2-ethylhexyl trimellitate, tri-trimellitate Tridecyl, trimethylolpropane tri-2-ethylhexyl, trimethylolpropane triisostearate, pentaerythritol tetra-2-ethylhexanoate, glycerin tri-2-ethylhexanoate, trimethylolpropane triisostearate, cetyl 2-ethylhexanoate, glycerin trimyristate, tri(caprylic / capric)glyceryl, tri(caprylic / capric / myristic / stearic)glyceryl, tri-2-heptylundecanoic acid glyceride, castor oil fatty acid methyl ester,Oleyl oleate, 2-heptyl undecyl palmitate, diisobutyl adipate, di(phytosteryl / octyldodecyl) lauroyl glutamate, di(octyldodecyl / phytosteryl / behenyl) lauroyl glutamate, di-2-heptyl undecyl adipate, ethyl laurate, bisethoxydiglycol cyclohexane-1,4-dicarboxylate, 2-ethylhexyl succinate, diethoxyethyl succinate, ethyl acetate, butyl acetate, amyl acetate, triethyl citrate, dimer-dilino Ester oils such as phytosteryl / isostearyl / cetyl / stearyl / behenyl triisostearate, polyglyceryl-2 triisostearate, dimer dilinoleyl dimer dilinoleate, dipentaerythrityl tripolyhydroxystearate, and tri(behenic acid / isostearate / eicosandioic acid)glyceryl; avocado oil, linseed oil, camellia oil, macadamia nut oil, corn oil, olive oil, safflower oil, apricot kernel oil, cinnamon oil, jojoba oil, grape seed oil, sunflower oil, almond oil, southern Oils and fats such as cassia oil, rapeseed oil, sesame oil, cocoa butter, coconut oil, hardened coconut oil, palm oil, palm kernel oil, Japan wax kernel oil, Japan wax, wheat germ oil, rice germ oil, rice bran oil, cottonseed oil, soybean oil, peanut oil, tea seed oil, evening primrose oil, etc.; waxes such as candelilla wax, rice bran wax, cotton wax, carnauba wax, lanolin, shellac wax, and beeswax; methylpolysiloxane, methylphenylpolysiloxane, decamethylcyclopentasiloxane, methylcyclopentasiloxane, highly polymerized methylpolysiloxane, octamethylcyclotetra ... Examples of the silicones include siloxanes such as lasiloxane, methyl hydrogen polysiloxane, methyl trimethicone, dimethiconol, and dimethiconol crosspolymer, alkyl-modified silicones such as caprylyl methicone, crosslinked methyl polysiloxane, crosslinked alkyl-modified silicone, acrylic silicone, and silicone resin, and higher alcohols such as cetanol, cetostearyl alcohol, stearyl alcohol, behenyl alcohol, octyldodecanol, and isostearyl alcohol.

[0058] The base or carrier may be used alone or in combination of two or more.

[0059] [Additives] The emulsion composition for topical use of the present invention may contain known additives that are added to pharmaceuticals, quasi-drugs, or cosmetics, such as antioxidants, preservatives, pH adjusters, stabilizers, antiseptics, colorants, fragrances, powders, and / or gloss-imparting agents, within the scope of not impairing the effects of the present invention.

[0060] Examples of antioxidants include dibutylhydroxytoluene, butylhydroxyanisole, sorbic acid, sodium sulfite, tocopherol, tocopherol derivatives, erythorbic acid, and L-cysteine ​​hydrochloride.

[0061] Examples of antiseptics and preservatives include benzoic acid, sodium benzoate, dehydroacetic acid, sodium dehydroacetate, isobutyl parahydroxybenzoate, isopropyl parahydroxybenzoate, butyl parahydroxybenzoate, ethyl parahydroxybenzoate, propyl parahydroxybenzoate, benzyl parahydroxybenzoate, methyl parahydroxybenzoate, phenoxyethanol, benzyl alcohol, chlorobutanol, sorbic acid and its salts, chlorhexidine gluconate, caprylhydroxysamic acid, iodopropynyl butylcarbamate, 1,2-pentanediol, 2,4-hexanediol, 1,2-hexanediol, and 1,2-octanediol.

[0062] Examples of pH adjusters include inorganic acids (such as hydrochloric acid and sulfuric acid), organic acids (such as lactic acid, sodium lactate, citric acid, sodium citrate, succinic acid and sodium succinate), inorganic bases (such as potassium hydroxide and sodium hydroxide), and organic bases (such as triethanolamine, diisopropanolamine and triisopropanolamine).

[0063] The stabilizer may, for example, be dibutylhydroxytoluene or butylhydroxyanisole.

[0064] Examples of colorants include titanium oxide, zinc oxide, iron oxide, organic pigments, chromium oxide, and powder.

[0065] Powders may also be blended to improve the feel or impart a makeup effect. Specific examples of such powders include boron nitride, silica, alumina, aluminum hydroxide, metal soap, silicone powder, amino acids, polymethyl methacrylate, talc, mica, synthetic mica, barium sulfate, sericite, and cellulose beads.

[0066] Examples of gloss-imparting agents include mica, glass flakes, and the like. The gloss-imparting agent is not limited to any particular one, but it is also preferable that the surface of mica, synthetic mica, talc, or glass flakes is coated with titanium oxide, iron oxide, silica, or the like. Examples of gloss-imparting agents include titanium oxide-coated mica in which the surface of mica is coated with titanium oxide, iron oxide-coated mica in which the surface of mica is coated with iron oxide, iron oxide / titanium oxide-coated mica in which the surface of mica is coated with titanium oxide and then further coated with titanium oxide, titanium oxide / silica-coated mica in which the surface of mica is coated with titanium oxide and then further coated with silica, titanium oxide-coated synthetic mica in which the surface of synthetic mica is coated with titanium oxide, iron oxide-coated synthetic mica in which the surface of synthetic mica is coated with iron oxide, iron oxide / titanium oxide-coated synthetic mica in which the surface of synthetic mica is coated with titanium oxide and then further coated with iron oxide, and synthetic mica in which the surface of synthetic mica is coated with titanium oxide and then further coated with silica. Titanium oxide / silica coated synthetic mica, titanium oxide coated talc having a titanium oxide surface coated on talc, iron oxide coated talc having iron oxide coated on the surface of talc, iron oxide / titanium oxide coated talc having titanium oxide coated on the surface of talc and then further coated with iron oxide, titanium oxide coated glass flakes having titanium oxide coated on the surface of glass flakes, iron oxide coated glass flakes having iron oxide coated on the surface of glass flakes, iron oxide / titanium oxide coated glass flakes having titanium oxide coated on the surface of glass flakes and then further coated with iron oxide, titanium oxide / silica coated glass flakes having titanium oxide coated on the surface of glass flakes and then further coated with silica, etc. can also be used.

[0067] The additives may be used alone or in combination of two or more.

[0068] [Other active ingredients] The emulsified topical composition of the present invention may contain other active ingredients within the scope of not impairing the effects of the present invention. Specific examples of active ingredients include cooling ingredients, moisturizing ingredients, anti-inflammatory ingredients, antibacterial or bactericidal ingredients, vitamins, amino acids or derivatives thereof, cell activating ingredients, anti-aging ingredients, blood circulation promoting ingredients, keratin softening ingredients, functional ingredients, and astringent ingredients.

[0069] [Manufacturing method] The method for producing the emulsified topical composition of the present invention is not particularly limited, and the stirring method during emulsification, emulsification temperature, order of adding the oil phase and the aqueous phase, and addition speeds thereof may be appropriately set.

[0070] Specifically, the oil phase and the aqueous phase are prepared by mixing them after heating and dissolving as necessary, and the oily component is gradually added to the aqueous phase at room temperature, and emulsified by mechanical stirring using a homogenizer or the like, but the method is not particularly limited to these. In addition, each component can be emulsified after being preliminarily prepared in advance according to its properties. For example, the (B) component is preferably dispersed in water or an aqueous phase in advance.

[0071] [Formulation] The emulsified composition for external use of the present invention can be mixed with a base or carrier that is usually used in drugs, quasi-drugs, cosmetics, etc., and, if necessary, with additives. It may be produced according to the method described in the General Provisions for Preparations of the Japanese Pharmacopoeia, 18th Edition.

[0072] The form of the emulsified topical composition is not particularly limited, and examples thereof include liquids, suspensions, emulsions, creams, ointments, gels, liniments, lotions, patches, etc. Among these, liquids, suspensions, emulsions, creams, ointments, gels, lotions, and patches are preferred, and creams, emulsions, ointments, lotions, and gels are more preferred.

[0073] The emulsified topical composition of the present invention contains an oily component and an aqueous component, and is preferably an oil-in-water type emulsified topical composition, typically in the form of a cream, emulsion, or the like.

[0074] Specific examples of the uses of the emulsion topical composition of the present invention include basic cosmetics such as emulsions, gels, creams, beauty essences, sunscreen cosmetics, hand creams, and body creams; face makeup cosmetics such as makeup bases, lip cosmetics such as lip creams; and hair cosmetics such as styling agents. The emulsion topical composition may have two or more of these uses. Among these, sunscreen cosmetics for the skin are preferred, and sunscreen cosmetics that also serve as makeup bases are more preferred. It can also be a multifunctional cosmetic that protects the skin from light such as ultraviolet rays during the day and simultaneously enables skin care. It can also be a cosmetic that improves the texture and luster of the skin. That is, the emulsion topical composition of the present invention can be a skin emulsion topical composition that is applied to the skin. The formulation form of the emulsion topical composition for skin is the same as that of the emulsion topical composition of the present invention. In addition, the base or carrier, additives, and active ingredients that can be used, as well as their preferred ones, are the same as those of the emulsion topical composition of the present invention.

[0075] Furthermore, the emulsified composition for external use of the present invention can be used once or more per day depending on the application, etc., and can be used in a known or commonly used manner and dosage.

[0076] [container] The emulsified topical composition of the present invention can be stored and used in a container of a shape and material appropriately selected according to the purpose and application of use. Specific examples of the container include a spray type, a bottle type, a tube type, a jar type, a dropper type, a dispenser type, a stick type, and a pouch bag.

[0077] [Application] The emulsified topical composition of the present invention effectively exerts the physiological activities of the ultraviolet absorber and the water-soluble ascorbic acid derivative, and is therefore useful as a formulation with multiple functions, such as anti-inflammatory effects, melanin production inhibitory effects, anti-wrinkle effects, and sunburn prevention effects.

[0078] [How to improve usability] The present invention also achieves an improvement in the feel of use of the emulsified topical composition. Here, the improvement of feel of use refers to good spreadability, uniformity of application, or adhesion when applied to the skin. When used as a makeup base, even if a makeup foundation or the like is applied to the application site, the makeup preparation is unlikely to float or adhere unevenly, resulting in a good finish (beauty), and the makeup is unlikely to break down over time, which may result in good makeup wear.

[0079] In the method of the present invention, the conditions for the emulsified composition for external use are the same as those used in the above [Emulsified composition for external use].

[0080] [Stability improvement method] The emulsified composition for external use of the present invention is also excellent in stability. Here, excellent in stability means, but is not limited to, that the composition has little change in properties even under high temperature heat stress. Alternatively, it means that the composition has little change in properties under heat fluctuation stress. More specifically, it means that even when the emulsified composition for external use is stored, separation and the like are suppressed, the decrease in the uniformity of emulsion is suppressed, and a good emulsion state is maintained.

[0081] The stability improving method of the present invention can be a method for improving the storage stability of an emulsified topical composition by coexisting a composition containing (A) a water-soluble ascorbic acid derivative; (C) an ultraviolet absorber, and (D) a thickener with (B) cellulose nanofibers. In the method of the present invention, the conditions for the emulsified composition for external use are the same as those used in the above [Emulsified composition for external use].

[0082] [How to improve UV protection ability] The emulsified topical composition of the present invention also has excellent UV protection ability (including water resistance). Here, water resistance refers to the fact that the UV absorbing effect is maintained or the decrease in the effect is suppressed even when the emulsified topical composition is applied to a target such as the skin and then contacted with water. The method for improving UV protection ability of the present invention can be a method for improving UV protection ability by causing (B) cellulose nanofibers to coexist with a composition containing (A) a water-soluble ascorbic acid derivative; (C) an UV absorber; and (D) a thickener.

[0083] In the method of the present invention, the conditions for the emulsified composition for external use are the same as those used in the above [Emulsified composition for external use]. EXAMPLES

[0084] Next, the present invention will be specifically described with reference to examples, but the present invention is not limited to the following examples.

[0085] The emulsified compositions for external use shown in Tables 1 to 3 were prepared. The compositions were prepared by preparing the oil phase and the water phase by heating, dissolving and mixing, respectively, and then gradually incorporating the oil phase into the water phase at room temperature while thoroughly stirring using a homomixer to obtain the desired emulsified composition for external use. The cellulose nanofibers were first dispersed in water and allowed to blend before being used for preparation. It was confirmed that Comparative Example 1-1 and Example 1-1 had similar viscosities after preparation. The content of cellulose nanofiber in Tables 1 to 3 indicates the content in the composition. The unit of the amount of each component is mass%.

[0086] [Test Example 1] Evaluation of Usability Three expert panelists applied the compositions to the skin and evaluated the composition's spreadability and adhesion to the skin according to the evaluation criteria. The results of the discussion by the three panelists are shown in Table 1. In this test example, the thickness of the spread of the composition specifically refers to the thickness of the composition felt on the fingertips when applying the composition, compared to when water is applied using the same application method, and the adhesion to the skin refers to the feeling of the composition adhering tightly to the skin.

[0087] <Evaluation criteria> × The coating spreads thinly and does not feel adhesive. △ The coating spreads thinly and feels tightly adherent. 〇 The coating spreads thickly and feels tightly attached. ◎ The coating spreads thickly and feels very adhesive

[0088] [Test Example 2] Evaluation of makeup smudging 0.1 g of the emulsified external composition shown in Table 1 was evenly spread on a Bioskin plate (black, manufactured by Bealux) in a circle with a diameter of 8 cm, and then dried for 3 minutes. Then, face powder was taken on a circular puff with a diameter of 4 cm, and pressed against the part to which the composition was applied, so that the face powder was adhered. Next, face powder that did not adhere was removed from the Bioskin plate using a brush. The entire 3 cm circle with the same center as the circle to which the composition was applied was rubbed with the fingertips in a circular motion. The state of adhesion of the face powder and the appearance of the part after rubbing were visually observed, and evaluated according to the evaluation criteria.

[0089] In this test example, makeup smudging refers to the state of adhesion of face powder layered on top of the composition after the composition has been applied to the skin. Makeup smudging refers to a state in which the face powder layered on top of the composition adheres unevenly, resulting in uneven coloring that is poor in terms of makeup effects, or in which the powder clumps together and is observed to be lumpy. Makeup smudging impairs the makeup effects and results in a poor appearance. The results are shown in Table 1. The appearance of the test results is illustrated in Figure 1. (From the left: Example 1-1, Comparative Example 1-2)

[0090] <Evaluation criteria> ×: The face powder is not applied evenly and clumps are observed. Clumpy clumps are observed in the rubbed areas. △ The face powder is not evenly applied and the makeup effect is poor. No clumps are observed in the rubbed area. ○ Face powder adheres slightly unevenly, but the makeup effect is good. The rubbed area is slightly uneven, but the makeup effect is good. ◎ The face powder is applied evenly all over the face, and there is no unevenness in the rubbed areas, so the makeup effect is good.

[0091] [Table 1] *1 LeoCrysta C-2SP (manufactured by Daiichi Kogyo Seiyaku Co., Ltd.) *2 AuroVisco CS (manufactured by Oji Holdings and Nikko Chemicals) *3 Cellenpia CS-01C (manufactured by Nippon Paper Industries Co., Ltd.) *4 Contains SEPIGEL 305 (manufactured by SEPPIC SA), polyacrylic acid amide (40%), light liquid isoparaffin (24%), polyoxyethylene lauryl ether (6%) and purified water (30%). *5 Contains Nikomulus 41 (manufactured by Nikko Chemicals), behenyl alcohol (50%), decaglyceryl pentastearate (38%) and sodium stearoyl lactylate (12%).

[0092] As shown in Table 1, the comparative composition not containing the (B) component had a thin spread thickness, poor adhesion, and poor makeup smudging. The compositions of the examples containing cellulose nanofibers had a good feel when used and suppressed makeup smudging. Since Comparative Example 1-1 and Example 1-1 have the same viscosity, it is believed that the effect of the present invention in terms of feel when used and suppression of makeup smudging is not due to viscosity, but rather that the inclusion of cellulose nanofibers improves spread thickness, improves adhesion, and suppresses makeup smudging. Although the mechanism of action is unclear, it is believed that cellulose nanofibers interact with the (A), (C), and (D) components contained in the aqueous phase and oil phase of the composition in an emulsified state, contributing to uniform dispersion, increased affinity with the skin, and increased affinity with makeup preparations. Three panelists commented that Comparative Example 1-1 felt sticky after application, but Example 1-1 did not feel sticky, and the skin surface had a smooth and tidy feel and appearance. This suggests that cellulose nanofibers interact with the thickener (D) in the composition to change the viscous properties of the composition, suppressing the poor usability of the thickener (D), improving application and adhesion, and making the skin look smooth and silky. Furthermore, makeup smudging was evaluated on the cheeks of panelists. Specifically, 0.05 g of the composition was applied to the cheek in a circle with a diameter of 4 cm, and a circular puff with a diameter of 3 cm that had taken face powder was pressed against the composition application area, and the entire 2.5 cm circle with the same center as the composition application area was rubbed with fingertips in a circular motion. As a result, in Example 1-1, the face powder was uniformly attached overall, and even after rubbing with fingers, the makeup effect was good, makeup smudging did not occur, and makeup lifting did not occur. When Comparative Example 1-2 was similarly evaluated on the cheeks of panelists, it was observed that the face powder was not uniformly applied to Comparative Example 1-2 and clump-like aggregation was observed. As shown in Figure 1, the composition of Comparative Example showed uneven color and clump-like aggregation, which were poor in terms of makeup effect, and in addition to the insufficient makeup effect, the state of the composition of Comparative Example caused severe makeup breakdown in actual use, and it was considered to be inferior in convenience for users.In one embodiment of the emulsion topical composition of the present invention, the emulsion topical composition can be applied uniformly, and therefore, when a makeup product is applied over the emulsion topical composition, the makeup product can be applied uniformly, enhancing the makeup effect and providing a good aesthetic appearance. In one embodiment of the emulsion topical composition of the present invention, the emulsion topical composition has high adhesion to the application area, so that the uniform adhesion can be maintained for a long time even if the application area moves during daily activities. Furthermore, the makeup product applied over the emulsion topical composition also maintains uniform adhesion even during various daily activities, so that a good makeup effect can be maintained for a long time.

[0093] [Test Example 3] UV protection effect test The composition shown in Table 2 was applied to a polymethyl methacrylate (PMMA) plate at a concentration of 1.3 mg / cm 2 After drying in a dark place for 15 minutes, the absorbance at 280 to 400 nm was measured using an SPF analyzer (manufactured by Labsphere). The absorbance was measured at nine different points on the same PMMA plate, and the average value was taken as the absorbance of the composition. Next, the area under the absorbance curve was calculated. (Area under the absorbance curve before water treatment) Next, the PMMA plate was immersed in tap water in a stainless steel container for 10 seconds, then removed from the container, and the water remaining on the surface was removed with a tissue or the like without rubbing the PMMA plate (water treatment). The absorbance of the composition was measured in the same manner as above, and the area under the absorbance curve was calculated. (Area under the absorbance curve after water treatment)

[0094] The remaining absorbance rate after water treatment was calculated using formula 1. The results are shown in the table. [Formula 1] Absorbance remaining rate after water treatment (%) = [(area under the absorbance curve after water treatment) / (area under the absorbance curve before water treatment) × 100]

[0095] The conditions in this test example are more severe than those in which an emulsified topical composition applied in actual use comes into contact with tap water, rain, a swimming pool, sweat, and the like.

[0096] <Evaluation criteria> × Residual absorbance rate is less than 50% △ Residual absorbance rate is 50% or more but less than 60% ○ Residual absorbance rate is 60% or more but less than 70% ◎ Residual absorbance rate is 70% or more and less than 80% ◎◎Remaining absorbance rate is 80% or more

[0097] [Table 2] As shown in Table 2, the comparative example not containing the (B) component had a low absorbance retention rate, while the example containing cellulose nanofiber had a high absorbance retention rate and improved UV protection effect. Although the mechanism of action is unclear, it was thought that the inclusion of cellulose nanofibers could suppress the effect of contact with water on the emulsified state of the UV absorber in the emulsion composition. As can be seen from this test example, the emulsion composition of the present invention has excellent water resistance, so that the UV protection effect is not easily reduced even when applied to skin wet with water or sweat, making it suitable for reapplication during the day. In addition, the emulsion composition of the present invention can maintain a high UV protection effect even when it comes into contact with sweat or water such as in a pool after application, and is therefore convenient for users.

[0098] [Test Example 4] Evaluation of thermal stability The compositions shown in Table 3 were prepared, and the emulsified state immediately after preparation and after storage was observed. The emulsified state of the composition immediately after preparation and the degree of change in the emulsified state of the composition after storage were visually evaluated. Next, for compositions in which a change in appearance was observed, the glass bottles in which the composition immediately after preparation and the composition after storage were contained were each shaken to mix the compositions, and then the emulsified state of the composition immediately after preparation and the degree of change in the emulsified state of the composition after storage were evaluated.

[0099] Specifically, the compositions of each Example and Comparative Example were filled into a 30 mL glass bottle, sealed, and stored in a thermostatic chamber at 60°C for two weeks. After storage, the compositions were left to stand overnight at room temperature, and the appearance of the compositions at room temperature was visually observed and evaluated according to the evaluation criteria for the emulsified state. Next, the glass bottle was moved back and forth vertically over a distance of 30 cm three times, and immediately thereafter, the fluidity of the compositions was observed and evaluated. The results are shown in Table 3.

[0100] <Evaluation criteria for emulsion state> × Separation or syneresis is observed, and the emulsified state cannot be maintained. Even when the glass bottle is shaken to mix the composition, the emulsified state is not uniform, and the appearance is poor compared to the composition immediately after preparation. △: No separation or syneresis is observed, but the emulsified state is partially non-uniform. Even when the glass bottle is shaken to mix the composition, the emulsified state is non-uniform and the appearance is poor compared to the composition immediately after preparation. ○ No separation or syneresis was observed, but the emulsified state was slightly non-uniform. When the glass bottle was shaken to mix the composition, the emulsified state was uniform and good, the same as the composition immediately after preparation. ◎ No separation or syneresis was observed, and a uniform emulsified state was maintained throughout. When the glass bottle was shaken to mix the composition, the emulsified state was uniform throughout, and was good, the same as the composition immediately after preparation.

[0101] [Table 3]

[0102] As shown in Table 3, in the comparative example not containing component (B), separation occurred and the thermal stability of the emulsion was significantly low. The examples containing cellulose nanofibers had high thermal stability. Although the mechanism of action is unclear, it is thought that the components (A), (C), and (D) contained in the aqueous phase and oil phase, respectively, in the emulsion composition interact with each other to deteriorate the emulsion state, whereas the inclusion of cellulose nanofibers maintained the emulsion state uniformly.

[0103] The emulsion composition for external use according to one embodiment of the present invention had a good emulsion state immediately after production, and separation of the composition due to high-temperature storage was suppressed. It was also shown to have excellent usability. In addition, the emulsion composition for external use according to one embodiment of the present invention was shown to have good usability, in that it is easy to apply because the uniform thickness can be felt when applied, and the application area can be easily recognized and applied uniformly because the adhesion of the composition to the skin can be felt. In addition, the emulsion composition for external use according to one embodiment of the present invention was shown to have excellent usability, in that the face powder applied over it is uniformly attached, thereby suppressing makeup smudges and providing a good makeup effect (Figure 1). Although the mechanism of action is unclear, it is believed that the dispersion state of the (B) component in the mesh of the gel network structure of the (D) component in the emulsion composition for external use contributes to the effect of the invention. The formation and maintenance of the gel network structure of the (D) component is affected by the interaction of the (A) component with the (D) component, and therefore it is believed to be affected by the dispersion state of the (B) component within the structure. The interaction between components (A), (B), (C), and (D) produces the effect of preventing makeup from smudging according to the present invention, and provides users with a new sensation of excellent application and adhesion.

[0104] It has been shown that the emulsified topical composition according to one embodiment of the present invention has excellent water resistance in terms of its ultraviolet ray absorption protection effect. When the composition is used in daily life and comes into contact with tap water, rain, swimming pools, sweat, etc., the emulsified topical composition according to one embodiment of the present invention has high water resistance, so that the ultraviolet ray absorption protection effect is sustained.

Claims

1. (A) a water-soluble ascorbic acid derivative; (B) Cellulose nanofiber; (C) an ultraviolet absorber; and (D) Thickener An emulsified topical composition comprising:

2. The emulsified topical composition according to claim 1 , wherein the content of the component (A) is 1.0% by mass or more.

3. The emulsified topical composition according to claim 1, comprising 0.1 to 0.7 parts by mass of component (D) per 1 part by mass of component (B).

4. The emulsified topical composition according to claim 1, wherein the component (D) is at least one selected from the group consisting of acrylic thickeners consisting of acrylic acid / alkyl methacrylate copolymers, hydroxyethyl acrylate / sodium acryloyldimethyltaurate copolymers, sodium acrylate / sodium acryloyldimethyltaurate copolymers, ammonium polyacrylate, sodium acrylate / sodium acryloyldimethyltaurate copolymers, polyacrylic acid amides, acrylamide / sodium acryloyldimethyltaurate copolymers, and acrylamide / ammonium acrylate copolymers, vinyl thickeners consisting of polyvinyl alcohol, polyvinylpyrrolidone, and carboxyvinyl polymers, and acidic mucopolysaccharides consisting of alginic acid, chondroitin sulfate, and salts thereof.

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