Topical skin preparation

Abstract

To provide a sunscreen topical skin preparation which exhibits excellent usability while containing an anti-skin-aging component.SOLUTION: The present invention relates to a sunscreen topical skin preparation containing the following components (A) and (B): (A) 0.2 to 1.0 mass% of dipotassium glycyrrhizinate relative to the total mass of the sunscreen topical skin preparation; (B) ethylhexyl salicylate and / or tris-ethylhexyl oxycarbonyl anilinotriazine.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to a sunscreen for external use on the skin. [Background technology]

[0002] Various UV care cosmetics have been developed to prevent damage to the skin caused by ultraviolet rays. One type of UV care cosmetic is a sunscreen cosmetic (sunscreen, sun protector), which contains ultraviolet protection agents such as ultraviolet absorbers and ultraviolet scattering agents to protect the skin from the harmful effects of ultraviolet rays in sunlight.

[0003] In recent years, there has been a strong demand for sunscreen cosmetics as multifunctional preparations that contain ingredients that not only provide ultraviolet protection but also improve aging symptoms such as wrinkles caused by ultraviolet rays or the like.

[0004] Dipotassium glycyrrhizinate is known as one of the components that has a wrinkle-improving effect (Patent Document 1), but cosmetics containing dipotassium glycyrrhizinate may cause a sticky feeling. [Prior art documents] [Patent documents]

[0005] [Patent Document 1] Patent Publication 2019-108278 Summary of the Invention [Problem to be solved by the invention]

[0006] In view of the above circumstances, an object of the present invention is to provide a sunscreen for external use on the skin that contains dipotassium glycyrrhizinate but has a reduced sticky feeling. [Means for solving the problem]

[0007] The present inventors conducted studies to solve the above problems and found that by using a combination of a specific amount of dipotassium glycyrrhizinate and a specific ultraviolet absorber, a sunscreen topical skin preparation that meets the above problems can be produced, and thus completed the present invention. That is, the gist of the present invention relates to the following.

[0008] [1] The following components (A) and (B): (A) 0.2 to 1.0% by mass of dipotassium glycyrrhizinate relative to the total amount of the sunscreen skin preparation, (B) ethylhexyl salicylate and / or tris(ethylhexyloxycarbonyl)anilinotriazine, A sunscreen for skin application containing the compound. [2] The sunscreen topical skin preparation according to [1], containing 0.1 to 15 mass% of component (B) based on the total mass of the sunscreen topical skin preparation. [3] The sunscreen for topical skin preparation according to [1] or [2], wherein the mass ratio of the contents of the components (A) and (B) ((B) / (A)) is 0.5 to 15. [4] The sunscreen topical skin preparation according to any one of [1] to [3], further comprising a component (C) ultraviolet scattering agent. [5] A sunscreen for topical skin application according to [4], wherein the ultraviolet scattering agent of component (C) contains fine particle titanium dioxide and / or fine particle zinc oxide. [6] A sunscreen for topical skin application according to [4] or [5], wherein the ultraviolet scattering agent of component (C) has been subjected to a hydrophobizing treatment. [7] The sunscreen topical skin preparation according to any one of [4] to [6], containing 0.01 to 15 mass% of component (C) based on the total mass of the sunscreen topical skin preparation. [8] The sunscreen topical skin preparation according to any one of [1] to [7], further comprising a component (D) an ultraviolet absorber. [9] A sunscreen for topical skin preparation according to [8], wherein the ultraviolet absorber of component (D) contains ethylhexyl methoxycinnamate and / or dimethylaminohydroxybenzoylhexyl benzoate.

[10] The sunscreen topical skin preparation according to [8] or [9], containing 0.1 to 15 mass% of component (D) based on the total mass of the sunscreen topical skin preparation.

[11] The following components (A) and (B): (A) 0.2 to 1.0% by mass of dipotassium glycyrrhizinate relative to the total amount of the sunscreen skin preparation, (B) ethylhexyl salicylate and / or tris(ethylhexyloxycarbonyl)anilinotriazine, A method for producing a sunscreen topical skin preparation, comprising the step of blending Effect of the Invention

[0009] According to the present invention, it is possible to provide a sunscreen for external use on the skin which contains dipotassium glycyrrhizinate as an ingredient for preventing skin aging and yet has a reduced sticky feeling. Furthermore, the sunscreen composition for external use on the skin of the present invention suppresses the squeaky feeling and dry feeling, and is also excellent in suppressing crystal precipitation. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0010] The present invention will now be described. <Sunscreen for skin> One aspect of the present invention is The present invention relates to a sunscreen for external use on the skin (hereinafter, sometimes referred to as "the sunscreen for external use on the skin of the present invention") containing the following components (A) and (B): (A) dipotassium glycyrrhizinate in an amount of 0.2 to 1.0% by mass based on the total amount of the sunscreen skin preparation, (B) Ethylhexyl salicylate and / or trisethylhexyloxycarbonylanilinotriazine.

[0011] The present inventors have conducted various investigations in search of a sunscreen for external use on the skin that contains dipotassium glycyrrhizinate as an ingredient for preventing skin aging, yet is less sticky.

[0012] Among them, the present inventors have succeeded in creating a sunscreen skin topical preparation that contains dipotassium glycyrrhizinate and does not feel sticky after application and has excellent usability by combining 0.2-1.0% by mass of dipotassium glycyrrhizinate with ethylhexyl salicylate and / or trisethylhexyloxycarbonylanilinotriazine as an ultraviolet absorbing agent, based on the total amount of the sunscreen skin topical preparation. Furthermore, they have found that such a sunscreen skin topical preparation has excellent usability in terms of suppressing the squeaky feeling and dry feeling, is also excellent in suppressing crystal precipitation, and has formulation stability. Based on these findings, the present invention has been completed.

[0013] <Component (A) Dipotassium Glycyrrhizinate> The sunscreen skin preparation for external use of the present invention contains dipotassium glycyrrhizinate as component (A). The dipotassium glycyrrhizinate used in the present invention may be an artificially synthesized product or may be obtained from natural products such as plants. It may also be provided in the form of a plant extract containing

[0014] Dipotassium glycyrrhizinate may be a commercially available product, or may be extracted from, for example, a plant of the genus Glycyrrhiza in the family Fabaceae, such as G. glabra, G. uralensis, G. inflata, etc.

[0015] The method of extracting dipotassium glycyrrhizinate from a plant of the genus Glycyrrhiza of the family Leguminosae is not particularly limited, and may be a conventional extraction method, that is, a 1-20-fold amount of water or a lower alcohol such as ethanol is added to the plant body or a processed product thereof as a solvent, and the mixture is stirred as required, and immersed for several days at room temperature or for several hours at a temperature near the boiling point, and insoluble matter is removed by filtration or the like, and then the solvent is removed by distillation under reduced pressure or the like as required, and the mixture may be purified and fractionated by column chromatography or the like, and used. A preferable example of a plant part for preparing a plant extract is, for example, an underground stem.

[0016] In the sunscreen skin topical preparation of the present invention, the content of component (A) is 0.2-1.0% by mass based on the total sunscreen skin topical preparation. This range allows for excellent effects to be obtained in the present invention. The content of component (A) may be 0.2% by mass or more, 0.3% by mass or more, or 0.5% by mass or more based on the total sunscreen skin topical preparation, and may be 1.0% by mass or less, 0.8% by mass or less, or 0.7% by mass or less, or any combination thereof that is not contradictory. The content of component (A) may be 0.2-1.0% by mass, 0.3-0.8% by mass, or 0.5-0.7% by mass based on the total sunscreen skin topical preparation.

[0017] When the content of component (A) is 0.2% by mass or more, sufficient anti-aging effect on skin can be obtained, and when it is 1.0% by mass or less, smooth spreading is obtained, a uniform cosmetic film is easily formed, and a sticky feeling is not easily generated. In addition, by using it in such a range, it is easy to obtain a better feeling of use such as no squeaky feeling or dry feeling, and the formulation stability is also easily obtained.

[0018] Component (B): Ethylhexyl salicylate and / or tris(ethylhexyloxycarbonyl)anilinotriazine The sunscreen skin topical preparation of the present invention contains, as component (B), ethylhexyl salicylate (abbreviated name for quasi-drugs, cosmetic name) (quasi-drug name: 2-ethylhexyl salicylate) and / or trisethylhexyloxycarbonylanilinotriazine (abbreviated name for quasi-drugs) (cosmetic name: ethylhexyl triazone; quasi-drug name: 2,4,6-tris[4-(2-ethylhexyloxycarbonyl)anilino]-1,3,5-triazine). As such ethylhexyl salicylate and trisethylhexyloxycarbonylanilinotriazine, commercially available products can be used.

[0019] As component (B), one or more of the compounds selected from ethylhexyl salicylate and trisethylhexyloxycarbonylanilinotriazine may be used in combination in the present invention. That is, as component (B), only ethylhexyl salicylate may be used, only trisethylhexyloxycarbonylanilinotriazine may be used, or ethylhexyl salicylate and trisethylhexyloxycarbonylanilinotriazine may be used.

[0020] In the sunscreen topical skin preparation of the present invention, the content of component (B) is not limited, but may be, for example, 0.1% by mass or more, 0.3% by mass or more, or 1% by mass or more, and 15% by mass or less, 10% by mass or less, or 5% by mass or less, based on the total weight of the sunscreen topical skin preparation. The content of component (B) may be 0.1 to 15% by mass, 0.3 to 10% by mass, or 1 to 5% by mass based on the total weight of the sunscreen topical skin preparation. By using the component (A) in this range, the cosmetic composition will feel less sticky after application, and will also be more likely to provide a more excellent feel when used, such as no squeaky or dry feeling, and will also be more likely to provide formulation stability.

[0021] In addition, when ethylhexyl salicylate and tris(ethylhexyloxycarbonyl)anilinotriazine are used in combination as the component (B), the above content is the total amount of the two. When ethylhexyl salicylate and tris(ethylhexyloxycarbonyl)anilinotriazine are used in combination, the mass ratio is not particularly limited, but may be, for example, 10:1 to 1:10, or 5:1 to 1:1.

[0022] In addition, the mass ratio of component (A) to component (B) in the present invention, expressed as the mass ratio (B) / (A) of component (B) to component (A), is not particularly limited from the viewpoints of usability, formulation stability, and the like, and may be, for example, 0.5 to 15, 1 to 10, or 3 to 6.

[0023] <Component (C) UV scattering agent> The sunscreen skin topical preparation of the present invention may contain an ultraviolet scattering agent as component (C). The type of ultraviolet scattering agent is not particularly limited as long as it is a known agent used in the field of skin topical preparations such as cosmetics, but is not particularly limited as long as it is, for example, a fine particle metal oxide having the function of scattering ultraviolet rays and can be incorporated into an emulsion composition. Examples of metal oxides include titanium oxide, titanium dioxide, zinc oxide, zirconium oxide, and cerium oxide. The ultraviolet scattering agent may be incorporated alone or in combination of two or more types.

[0024] The fine particle metal oxide has a particle size that is referred to as fine particles in the relevant technical field, and for example, has a primary particle size as measured by observation with an electron microscope of usually 5 nm to 100 nm, preferably 10 nm to 80 nm.

[0025] The ultraviolet scattering agent used in the present invention preferably contains one or two types selected from fine particle titanium oxide and fine particle zinc oxide, because these have excellent ultraviolet scattering effects.

[0026] The ultraviolet scattering agent used in the present invention can be prepared by a conventional method such as thermally decomposing a salt of the corresponding metal in a gas phase, but commercially available products can also be used.

[0027] In the present invention, the surface of the ultraviolet scattering agent is preferably coated with an inorganic compound such as silica, alumina, etc., or an organic compound such as a surfactant such as stearic acid, isostearic acid, sodium alginate, etc., or a silicone compound such as silicone oil, etc. When the coating treatment is performed, it can be performed by a known surface treatment method.

[0028] The UV scattering agent is preferably dispersible in an oil phase. Since the UV scattering agent dispersible in an oil phase is uniformly dispersed in the oil phase, the sunscreen topical skin preparation of the present invention in such a form has excellent water resistance and UV protection function.

[0029] As the oil-dispersible ultraviolet scattering agent, a preferred example is one that has been hydrophobized, for example, an ultraviolet scattering agent whose surface is coated with a hydrophobic compound.As such an oil-dispersible ultraviolet scattering agent, although not limited thereto, an ultraviolet scattering agent coated with a hydrophobic organic compound is preferably used.

[0030] In the sunscreen topical skin preparation of the present invention, the content of component (C) is not limited, and may be, for example, 0.01% by mass or more, 0.1% by mass or more, or 1% by mass or more, and 15% by mass or less, 10% by mass or less, or 6% by mass or less, or any compatible combination thereof, based on the total weight of the sunscreen topical skin preparation. Also, the content of component (C) may be 0.01 to 15% by mass, 0.1 to 10% by mass, or 1 to 6% by mass, based on the total weight of the sunscreen topical skin preparation. By using it within such a range, an excellent ultraviolet ray scattering effect can be obtained without impairing the effect of the present invention. When two or more kinds of components (C) are used in combination, the above content is the total amount of the two or more kinds. When two or more kinds of components (C) are used in combination, the mass ratio is not particularly limited.

[0031] <Component (D) UV absorber> The sunscreen skin topical preparation of the present invention may contain an ultraviolet absorber as component (D). The ultraviolet absorber of component (D) is an ultraviolet absorber other than ethylhexyl salicylate and tris(ethylhexyloxycarbonylanilinotriazine) of component (B).

[0032] The type of ultraviolet absorber is not particularly limited as long as it is a known one used in the field of external skin preparations such as cosmetics, and examples thereof include cinnamic acid-based ultraviolet absorbers, benzophenone-based ultraviolet absorbers, benzoic acid-based ultraviolet absorbers, salicylic acid-based ultraviolet absorbers, dibenzoylmethane-based ultraviolet absorbers, anthranilic acid-based ultraviolet absorbers, urocanic acid-based ultraviolet absorbers, and triazine-based ultraviolet absorbers. Specifically, cinnamic acid-based ultraviolet absorbers such as paramethoxycinnamate-2-ethylhexyl, paramethoxycinnamate isopropyl, paramethoxyhydrocinnamic acid diethanolamine salt, diparamethoxycinnamate-mono-2-ethylhexanoate glyceryl, methoxycinnamate octyl, and diisopropyl cinnamate methyl; 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfuric acid, 2-hydroxy-4-methoxybenzophenone-5-sodium sulfate, 2,4-dihydroxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, 2,2',4,Benzophenone-based UV absorbers such as 4'-tetrahydroxybenzophenone and 2-hydroxy-4-n-octoxybenzophenone; benzoic acid-based UV absorbers such as para-aminobenzoic acid, ethyl para-aminobenzoate, butyl para-aminobenzoate, 2-ethylhexyl para-dimethylaminobenzoate, glyceryl para-aminobenzoate, octyl para-dimethylaminobenzoate, amyl para-aminobenzoate, dimethylaminohydroxybenzoyl hexyl benzoate, and diethylaminohydroxybenzoyl hexyl benzoate; salicylic acid-based UV absorbers such as triethanolamine salicylate, homomenthyl salicylate, dipropylene glycol salicylate, methyl salicylate, ethylene glycol salicylate, phenyl salicylate, amyl salicylate, benzyl salicylate, isopropyl benzyl salicylate, and potassium salicylate; Examples of the ultraviolet absorbing agent include dibenzoylmethane ultraviolet absorbers such as 4-tert-butyl-4'-hydroxydibenzoylmethane, 4-isopropyldibenzoylmethane, 4-methoxydibenzoylmethane, and 4-tert-butyl-4'-hydroxydibenzoylmethane; anthranilic acid ultraviolet absorbers such as menthyl-O-aminobenzoate, 2-phenyl-benzimidazole-5-sulfuric acid, 2-phenyl-5-methylbenzoxazole, 3-(4-methylbenzylidene)camphor, 2-ethylhexyl-2-cyano-3,3-diphenylacrylate, 2-ethyl-2-cyano-3,3'-diphenylacrylate, 2-(2'-hydroxy-5-methylphenyl)benzotriazole, and menthyl anthranilate; urocanic acid ultraviolet absorbers such as ethyl urocanate; and triazine ultraviolet absorbers such as bisethylhexyloxyphenol methoxyphenyl triazine.

[0033] The ultraviolet absorber of component (D) preferably contains one or more kinds selected from cinnamic acid-based ultraviolet absorbers and benzoic acid-based ultraviolet absorbers, and among them, paramethoxycinnamic acid- It is preferable to include one or two selected from 2-ethylhexyl (quasi-drug label name) (cosmetic label name: ethylhexyl methoxycinnamate; abbreviated drug label name: ethylhexyl paramethoxycinnamate) and dimethylamino hydroxybenzoyl hexyl benzoate (cosmetic label name) (quasi-drug label name: 2-[4-(dimethylamino)-2-hydroxybenzoyl]benzoic acid hexyl ester). As the ultraviolet absorbing agent, a commercially available product can be used. The ultraviolet absorbing agent may be used alone or in combination of two or more kinds.

[0034] In the sunscreen topical skin preparation of the present invention, the content of component (D) is not limited, and may be, for example, 0.1% by mass or more, 0.3% by mass or more, or 1% by mass or more, and 15% by mass or less, 10% by mass or less, or 5% by mass or less, or any compatible combination thereof, based on the total weight of the sunscreen topical skin preparation. Also, the content of component (D) may be 0.1-15% by mass, 0.3-10% by mass, or 1-5% by mass, based on the total weight of the sunscreen topical skin preparation.

[0035] By using it in such a range, an excellent ultraviolet absorbing effect can be obtained in combination with component (B) without impairing the effects of the present invention. When two or more kinds of components (D) are used in combination, the above content is the total amount of the two or more kinds. When two or more kinds of components (D) are used in combination, the mass ratio is not particularly limited.

[0036] <External skin preparations> The formulation of the sunscreen skin topical preparation of the present invention is not particularly limited to an aqueous formulation or an emulsion type, but is preferably an emulsion type, and may be a water-in-oil type or an oil-in-water type, but is particularly preferably a water-in-oil emulsion type. The water-in-oil emulsion type is not particularly limited as long as the outermost phase is an oil phase, and may be a W / O type, an O / W / O type, a (W1+W2) / O type, or the like.

[0037] When the sunscreen skin preparation for external use of the present invention is in the form of an emulsion, it contains an aqueous phase component and an oil phase component. The sunscreen skin topical preparation of the present invention contains water as an aqueous phase component. The aqueous phase component may be any component that dissolves in water at 25 to 90° C. The oil phase component is not limited to oils, but generally includes powders and the like, and may be any component that undergoes phase separation from water after being suspended in water at 25 to 90° C. and left to stand for 1 hour. When the sunscreen skin preparation of the present invention is an emulsion type, the mass ratio of the aqueous phase component to the oil phase component is not particularly limited, but is preferably 30:70 to 90:10, more preferably 60:40 to 85:15.

[0038] The sunscreen skin topical preparation of the present invention can be used in the form of cosmetics, including medicines and quasi-drugs. Cosmetics are particularly preferred. Specific examples of cosmetics include skin care cosmetics such as lotion, milky lotion, and cream, makeup cosmetics such as makeup base and foundation, and sunscreen cosmetics such as sunscreen milky lotion and sunscreen cream. The cosmetic can be in a variety of forms, such as liquid, milky lotion, and cream.

[0039] ≪Optional ingredients≫ Furthermore, the sunscreen skin preparation for external use of the present invention may contain optional ingredients other than the above-mentioned ingredients, so long as the effects of the preparation are not impaired. The optional components are not particularly limited and may be any known components used in the field of skin external preparations such as cosmetics. The optional components may be used in the present invention alone or in combination of two or more.

[0040] Examples of such optional components include oils, powders, alcohols, ethers, moisturizers, surfactants, sequestering agents, pearlescent agents, amino acids, organic amines, polymer emulsions, pH adjusters, vitamins, antioxidants, preservatives, water-soluble polymers, fragrances, and various active ingredients.

[0041] Examples of oils include silicone oils, polar oils, natural oils, and hydrocarbons.

[0042] Silicone oils include dimethylpolysiloxane (dimethicone), cyclopentasiloxane, decamethylcyclopentasiloxane, caprylyl methicone, trimethylsiloxysilicate, and the like.

[0043] As polar oils, synthetic ester oils include isopropyl myristate, cetyl octanoate, octyldodecyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, decyl oleate, hexyldecyl dimethyloctanoate, cetyl lactate, myristyl lactate, lanolin acetate, isocetyl stearate, isocetyl isostearate, cholesteryl 12-hydroxystearate, ethylene glycol di-2-ethylhexyl, dipentaerythritol fatty acid ester, N-alkyl glycol monoisostearate, neopentyl glycol dicaprate, diisostearyl malate, glyceryl di-2-heptylundecanoate, trimethylolpropane tri-2-ethylhexyl, trimethylolpropane triisostearate, pentaneerythritol tetra-2-ethylhexyl, Glyceryl tri-2-ethylhexanoate, trimethylolpropane triisostearate, cetyl 2-ethylhexanoate, 2-ethylhexyl palmitate, glyceryl trimyristate, tri-2-heptylundecanoic acid glyceride, castor oil fatty acid methyl ester, oleic acid oil, cetostearyl alcohol, acetoglyceride, 2-heptylundecyl palmitate, diisobutyl adipate, N-lauroy Examples of such esters include 2-octyldodecyl l-glutamate, di-2-heptylundecyl adipate, ethyl laurate, di-2-ethylhexyl sebacate, 2-hexyldecyl myristate, 2-hexyldecyl palmitate, 2-hexyldecyl adipate, diisopropyl sebacate, 2-ethylhexyl succinate, isononyl isononanoate, ethyl acetate, butyl acetate, amyl acetate, and triethyl citrate.

[0044] Examples of natural oils include avocado oil, camellia oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, persic oil, wheat germ oil, sasanqua oil, castor oil, linseed oil, safflower oil, cottonseed oil, perilla oil, soybean oil, peanut oil, tea seed oil, kaya oil, rice bran oil, Chinese giri oil, Japanese tung oil, jojoba oil, germ oil, sunflower oil, triglycerin, glyceryl trioctanoate, and glyceryl triisopalmitate.

[0045] Examples of the hydrocarbon oil include isododecane, isohexadecane, squalane, hydrogenated poly(C6-12) olefin, and hydrogenated polyisobutene.

[0046] The powder may be spherical, needle-like, plate-like, or the like, and its shape is not particularly limited. Examples of the powder include inorganic white pigments (e.g., titanium dioxide, zinc oxide, etc.); inorganic red pigments (e.g., iron oxide (red oxide), iron titanate, etc.); inorganic brown pigments (e.g., γ-iron oxide, etc.); inorganic yellow pigments (e.g., yellow iron oxide, ocher, etc.); inorganic black pigments (e.g., black iron oxide, low-order titanium oxide, etc.); inorganic purple pigments (e.g., mango violet, cobalt violet, etc.); inorganic green pigments (e.g., chromium oxide, hydroxide chromium oxide, cobalt titanate, etc.); inorganic blue pigments (e.g. ultramarine, Prussian blue, etc.); pearl pigments (e.g. titanium oxide coated mica, titanium oxide coated bismuth oxychloride, titanium oxide coated talc, colored titanium oxide coated mica, bismuth oxychloride, fish scale foil, etc.); metal powder pigments (e.g. aluminum powder, copper powder, etc.); organic pigments such as zirconium, barium or aluminum lake (e.g. Red No. 201, Red No. 202, Red No. 204, Red organic pigments such as Color No. 205, Red No. 220, Red No. 226, Red No. 228, Red No. 405, Orange No. 203, Orange No. 204, Yellow No. 205, Yellow No. 401, and Blue No. 404, Red No. 3, Red No. 104, Red No. 106, Red No. 227, Red No. 230, Red No. 401, Red No. 505, Orange No. 205, Yellow No. 4, Yellow No. 5, Yellow No. 202, Yellow No. 203, Green No. 3, and Blue No. 1; natural pigments (e.g., chlorophyll, beta-carotene, etc.); inorganic powders (e.g., talc, kaolin, Mica, sericite, muscovite, phlogopite, synthetic mica, red mica, biotite, vermiculite, magnesium carbonate, calcium carbonate, aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, tungstate metal salts, magnesium, silica, alumina, zeolite, barium sulfate, calcined calcium sulfate, calcium phosphate, fluorapatite, hydroxyapatite, ceramic powder, boron nitride, etc.);Examples of the organic powders include polyamide resin powders (nylon powders), polyethylene powders, poly(methyl (meth)acrylate) powders, polystyrene powders, styrene and acrylic acid copolymer resin powders, silicone resin powders, benzoguanamine resin powders, polytetrafluoroethylene powders, cellulose powders, silicone composite spherical powders (e.g., (vinyl dimethicone / methicone silsesquioxane) crosspolymers, (diphenyl dimethicone / vinyl diphenyl dimethicone / silsesquioxane) crosspolymers, polysilicone-22, polysilicone-1 crosspolymers, etc.); metal soaps (e.g., zinc myristate, calcium palmitate, aluminum stearate); organically modified clay minerals (e.g., organically modified bentonite, organically modified hectorite, etc.);

[0047] Examples of alcohols include monohydric alcohols such as ethanol, isopropanol, cetanol, batyl alcohol, behenyl alcohol, palmitoleic alcohol, heptadecanol, 1-heptadecanol, stearyl alcohol, isostearyl alcohol, elaidyl alcohol, oleyl alcohol, linoleyl alcohol, elaidolinoleyl alcohol, linolenyl alcohol, elaidolinolenyl alcohol, ricinoleyl alcohol, nonadecyl alcohol, arachidyl alcohol, heneicosanol, and erucyl alcohol; ethylene glycol, 1,3-butylene glycol, trimethylene glycol, 1,2- Dihydric alcohols such as butylene glycol, propylene glycol, dipropylene glycol, propanediol, 1,2-pentanediol, 3-methyl-1,3-butanediol, tetramethylene glycol, 2,3-butylene glycol, pentamethylene glycol, 2-butene-1,4-diol, hexylene glycol, and octylene glycol; trihydric alcohols such as trimethylolpropane; tetrahydric alcohols such as pentaerythritol; pentahydric alcohols such as xylitol; polyhydric alcohol polymers such as triglycerin, tetraglycerin, and polyglycerin; sugar alcohols such as starch decomposition sugar reduced alcohols; polyglycerin; Alcohol alkyl ethers such as ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, ethylene glycol monophenyl ether, ethylene glycol monohexyl ether, ethylene glycol mono 2-methylhexyl ether, ethylene glycol isoamyl ether, ethylene glycol benzyl ether, and ethylene glycol isopropyl ether; alcohol alkyl ethers such as diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monobutyl ether, triethylene glycol monomethyl ether, triethylene glycol monoethyl ether, propylene glycol monomethyl ether, propylene glycol monoethyl ether, propylene glycol monobutyl ether, propylene glycol isopropyl ether, dipropylene glycol methyl ether, dipropylene glycol ethyl ether, and dipropylene glycol butyl ether; glycerin monoalkyl ethers such as xyl alcohol, selachyl alcohol, and batyl alcohol; Alcohol polymers such as diethylene glycol, triethylene glycol, polypropylene glycol, tetraethylene glycol, and polyethylene glycol; Glysolid; tetrahydrofurfuryl alcohol; POE-tetrahydrofurfuryl alcohol; POP-butyl ether; POP·POE-butyl ether; tripolyoxypropylene glycerin ether; POP-glycerin ether; POP-glycerin ether phosphate; POP·POE-pentaneerythritol ether, etc.

[0048] Examples of the ether include, in addition to those corresponding to the above-mentioned alcohols, ethylene glycol dimethyl ether, ethylene glycol diethyl ether, ethylene glycol dibutyl ether, diethylene glycol dimethyl ether, diethylene glycol diethyl ether, diethylene glycol methyl ethyl ether, ethylene glycol monomethyl ether acetate, ethylene glycol monoethyl ether acetate, ethylene glycol monobutyl ether acetate, ethylene glycol monophenyl ether acetate, ethylene glycol diadipate, ethylene glycol disuccinate, diethylene glycol monoethyl ether acetate, diethylene glycol monobutyl ether acetate, propylene glycol monomethyl ether acetate, propylene glycol monoethyl ether acetate, propylene glycol monopropyl ether acetate, and propylene glycol monophenyl ether acetate.

[0049] Examples of moisturizing agents include chondroitin sulfate and its salts, hyaluronic acid and its salts, mucoitin sulfate, caronic acid, atelocollagen, cholesteryl-12-hydroxystearate, sodium lactate, dl-pyrrolidone carboxylate, short-chain soluble collagen, diglycerin (EO)PO adduct, Rosa rugosa extract, Achillea millefolium extract, and Melilot extract.

[0050] The surfactants include anionic surfactants, cationic surfactants, amphoteric surfactants, and nonionic surfactants.

[0051] Examples of anionic surfactants include fatty acid soaps (e.g., sodium laurate, sodium palmitate, etc.); higher alkyl sulfates (e.g., sodium lauryl sulfate, potassium lauryl sulfate, etc.); alkyl ether sulfates (e.g., POE triethanolamine lauryl sulfate, sodium POE lauryl sulfate, etc.); N-acyl sarcosinates (e.g., sodium lauroyl sarcosinate, etc.); higher fatty acid amide sulfonates (e.g., sodium N-myristoyl-N-methyl taurine, sodium coconut oil fatty acid methyl tauride, sodium lauryl methyl tauride, etc.); phosphates (sodium POE oleyl ether phosphate, sodium POE stearyl ether phosphate, etc.); sulfosuccinates (e.g., sodium di-2-ethylhexyl sulfosuccinate, sodium monolauroyl monoethanolamide polyoxyethylene sulfosuccinate, sodium lauryl polypropylene glycol ... sodium citrate, etc.); alkylbenzene sulfonates (e.g., sodium linear dodecylbenzene sulfonate, triethanolamine linear dodecylbenzene sulfonate, linear dodecylbenzene sulfonic acid, etc.); higher fatty acid ester sulfate salts (e.g., sodium hydrogenated coconut oil fatty acid glycerin sulfate, etc.); N-acyl glutamates (e.g., monosodium N-lauroyl glutamate, disodium N-stearoyl glutamate, monosodium N-myristoyl-L-glutamate, etc.); sulfated oils (e.g., turmeric oil, etc.); POE alkyl ether carboxylic acids; POE alkyl allyl ether carboxylates; α-olefin sulfonates; higher fatty acid ester sulfonates; secondary alcohol sulfate salts; higher fatty acid alkylolamide sulfate salts; sodium lauroyl monoethanolamide succinate; ditriethanolamine N-palmitoyl aspartate; sodium caseinate, etc.

[0052] Examples of cationic surfactants include alkyltrimethylammonium salts (e.g., stearyltrimethylammonium chloride, lauryltrimethylammonium chloride, etc.); alkylpyridinium salts (e.g., cetylpyridinium chloride, etc.); distearyldimethylammonium chloride, dialkyldimethylammonium salts; poly(N,N'-dimethyl-3,5-methylenepiperidinium chloride); alkyl quaternary ammonium salts; alkyldimethylbenzylammonium salts; alkylisoquinolinium salts; dialkylmorphonium salts; POE alkylamines; alkylamine salts; polyamine fatty acid derivatives; amyl alcohol fatty acid derivatives; benzalkonium chloride; benzethonium chloride, etc.

[0053] Examples of amphoteric surfactants include imidazoline-based amphoteric surfactants (e.g., 2-undecyl-N,N,N-(hydroxyethylcarboxymethyl)-2-imidazoline sodium, 2-cocoyl-2-imidazolinium hydroxide-1-carboxyethyloxy disodium salt, etc.); betaine-based surfactants (e.g., 2-heptadecyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, lauryl dimethylaminoacetic acid betaine, alkyl betaine, amido betaine, sulfobetaine, etc.).

[0054] Examples of nonionic surfactants include polyether-modified silicones (e.g., polyethylene glycol-10 dimethicone, polyethylene glycol-12 dimethicone, PEG-9 polymethylsiloxyethyl dimethicone, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, PEG-9 polydimethylsiloxyethyl dimethicone, etc.); polyglycerin-modified silicones (e.g., polyglyceryl-3 disiloxane dimethicone, polyglyceryl-3 polydimethylsiloxyethyl dimethicone, etc.); sorbitan fatty acid esters (e.g., sorbitan monooleate, sorbitan monostearate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmit ... sorbitan stearate, sorbitan sesquioleate, sorbitan trioleate, diglycerol sorbitan penta-2-ethylhexyl acid, diglycerol sorbitan tetra-2-ethylhexyl acid, etc.); glycerin fatty acids (e.g., glycerin monocottonseed oil fatty acid, glycerin monoerucate, glycerin sesquioleate, glycerin monostearate, glycerin α,α'-oleic acid pyroglutamate, glycerin monostearate malate, etc.); propylene glycol fatty acid esters (e.g., propylene glycol monostearate, etc.); POE castor oil / hydrogenated castor oil derivatives (POE castor oil, POE hydrogenated castor oil, etc.); and non-hydrophilic nonionic surfactants such as glycerin alkyl ethers. Also, polyglycerol fatty acid esters (e.g., polyglyceryl monooleate, polyglyceryl monostearate, etc.); POE sorbitan fatty acid esters (e.g., POE sorbitan monooleate, POE sorbitan monostearate, POE sorbitan tetraoleate, etc.); POE sorbit fatty acid esters (e.g., POE sorbit monolaurate, POE sorbit monooleate, POE sorbit pentaoleate, POE sorbit monostearate, etc.); POE glycerin fatty acid esters (e.g., POE monooleates such as POE glycerin monostearate, POE glycerin monoisostearate, POE glycerin triisostearate, etc.);POE fatty acid esters (e.g., POE distearate, POE monodioleate, ethylene glycol distearate, etc.); POE alkyl ethers (e.g., POE lauryl ether, POE oleyl ether, POE stearyl ether, POE-behenyl ether, POE-2-octyldodecyl ether, POE cholestanol ether, etc.); POE alkyl phenyl ethers (e.g., POE nonylphenyl ether, etc.); Pluronic types (e.g., Pluronic (registered trademark), etc.); POE·POP alkyl ethers (e.g., POE·POP cetyl ether, POE·POP-2-decyltetradecyl ether, POE·POP monobutyl ether, POE·POP hydrogenated lanolin, POE·POP glycerin ether, etc.); tetra POE-tetra POP ethylenediamine condensates (e.g., Tetronic, etc.); POE castor oil hydrogenated castor oil derivatives (e.g., POE castor oil, POE hydrogenated castor oil, POE hydrogenated castor oil monoisostearate, POE hydrogenated castor oil triisostearate, POE hydrogenated castor oil monopyroglutamic acid monoisostearate diester, POE hydrogenated castor oil maleic acid, etc.); POE beeswax / lanolin derivatives (e.g., POE sorbitol beeswax, etc.); alkanolamides (e.g., coconut oil fatty acid diethanolamide, lauric acid monoethanolamide, fatty acid isopropanolamide, etc.); POE propylene glycol fatty acid esters; POE alkylamines; POE fatty acid amides; sucrose fatty acid esters; alkyl glucosides; alkyl ethoxy dimethylamine oxides; and hydrophilic nonionic surfactants such as trioleyl phosphate.

[0055] Examples of sequestering agents include 1-hydroxyethane-1,1-diphosphonic acid, 1-hydroxyethane-1,1-diphosphonic acid tetrasodium salt, disodium edetate, trisodium edetate, tetrasodium edetate, sodium citrate, sodium polyphosphate, sodium metaphosphate, gluconic acid, phosphoric acid, citric acid, ascorbic acid, succinic acid, edetic acid, and trisodium ethylenediaminehydroxyethyltriacetate.

[0056] Examples of pearlescent agents include glycol distearate and titanium mica.

[0057] Examples of the amino acid include neutral amino acids (e.g., threonine, cysteine, etc.), basic amino acids (e.g., hydroxylysine, etc.), etc. Examples of the amino acid derivatives include sodium acyl sarcosine (sodium lauroyl sarcosine), acyl glutamate, sodium acyl β-alanine, glutathione, pyrrolidone carboxylic acid, etc.

[0058] Examples of the organic amine include monoethanolamine, diethanolamine, triethanolamine, morpholine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, and 2-amino-2-methyl-1-propanol.

[0059] Examples of polymer emulsions include acrylic resin emulsions, polyethyl acrylate emulsions, acrylic resin liquids, polyacrylic alkyl ester emulsions, polyvinyl acetate resin emulsions, and natural rubber latex.

[0060] Examples of pH adjusters include buffers such as lactic acid-sodium lactate, citric acid-sodium citrate, and succinic acid-sodium succinate, and are usually used to adjust the pH of the internal phase (aqueous component).

[0061] Examples of vitamins include vitamins A, B1, B2, B6, C, E and their derivatives, pantothenic acid and its derivatives, biotin, etc.

[0062] Examples of antioxidants include tocopherols, dibutylhydroxytoluene (BHT), butylhydroxyanisole, pyrosulfite, gallic acid esters, phosphoric acid, citric acid, ascorbic acid, maleic acid, malonic acid, succinic acid, fumaric acid, cephalin, hexametaphosphate, phytic acid, and ethylenediaminetetraacetate.

[0063] Examples of preservatives include parabens and phenoxyethanol.

[0064] Examples of the water-soluble polymer include natural water-soluble polymers such as plant-based polymers (e.g., gum arabic, tragacanth gum, galactan, guar gum, carob gum, karaya gum, carrageenan, pectin, agar, quince seed, algae colloid (cassow extract), starch (rice, corn, potato, wheat), and glycyrrhizic acid); microbial polymers (e.g., xanthan gum, dextran, succinoglucan, pullulan, etc.); and animal-based polymers (e.g., collagen, casein, albumin, gelatin, etc.); semi-synthetic water-soluble polymers such as starch-based polymers (e.g., carboxymethyl starch, methylhydroxypropyl starch, etc.); cellulose-based polymers (hydroxypropylmethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, methylcellulose, ethylcellulose, hydroxypropylmethylcellulose stearoxy ether, sodium cellulose sulfate, carboxymethylcellulose, sodium carboxymethylcellulose, crystalline cellulose, cellulose powder, etc.); alginic acid-based polymers (e.g., sodium alginate, propylene glycol alginate, etc.), etc. Examples of the water-soluble synthetic polymer include polyoxyethylene polymers (for example, polyethylene glycol 20,000, 40,000, 60,000, etc.); polyethyleneimine; and cationic polymers.

[0065] Examples of the various active ingredients include anti-inflammatory agents (e.g., salicylic acid derivatives, hinokitiol, zinc oxide, allantoin, etc.); whitening agents (e.g., placenta extract, saxifrage extract, arbutin, resorcinol derivatives, etc.); various extracts (e.g., Phellodendron bark, Coptis japonica, Lithospermum root, Peony root, Swertia japonica, Birch, Sage, Loquat, Carrot, Aloe, Mallow, Iris, Grape, Coix seed, Loofah, Lily, Saffron, Cnidium rhizome, Angelica acutiloba, Hypericum perforatum, Ononis, Garlic, Capsicum annuum, Citrus chinensis, Angelica acutiloba, Seaweed, etc.), activators (e.g., Royal jelly, photosensitizers, cholesterol, etc.), sterol derivatives, etc.); blood circulation promoters (e.g., nonylic acid valenylamide, nicotinic acid benzyl ester, nicotinic acid β-butoxyethyl ester, capsaicin, zingerone, cantharides tincture, ichthammol, tannic acid, α-borneol, tocopherol nicotinate, inositol hexanicotinate, cyclandelate, cinnarizine, tolazoline, acetylcholine, verapamil, cepharanthine, γ-oryzanol, etc.); antiseborrheic agents (e.g., sulfur, thianthol, etc.); anti-inflammatory agents (e.g., tranexamic acid, thiotaurine, hypotaurine, etc.), etc.

[0066] These optional components may be added at any step in the present invention or before or after the step.

[0067] <Manufacturing method> One aspect of the present invention is The present invention relates to a method for producing a sunscreen for external use on the skin (hereinafter, sometimes referred to as the "production method of the present invention"), which comprises a step of blending the following components (A) and (B): (A) dipotassium glycyrrhizinate in an amount of 0.2 to 1.0% by mass based on the total amount of the sunscreen skin preparation, (B) Ethylhexyl salicylate and / or trisethylhexyloxycarbonylanilinotriazine. The matters explained in the section <Sunscreen for external use on skin> above are all applicable to the explanation of the production method of the present invention.

[0068] The manufacturing method of the present invention is characterized by producing a sunscreen topical preparation for skin with reduced stickiness by blending specific components (A) and (B). The specific ranges of the blending amounts and blending ratios of components (A) and (B) are the same as those explained in the above section on <Sunscreen topical preparation for skin>.

[0069] The method for producing the sunscreen skin preparation of the present invention can be carried out according to a conventional method, except that the above-mentioned essential components are contained. For example, the oil phase component is heated and dissolved, a powder component containing component (B) is added, and the aqueous phase component containing component (A) that has been heated and dissolved is added to the dispersed oil phase component, and emulsified with stirring to obtain a water-in-oil emulsion-type topical skin preparation. EXAMPLES

[0070] The present invention will be specifically described below with reference to examples. However, these are merely illustrative of the present invention and the scope of the present invention is not limited to these examples.

[0071] According to the formulation shown in Table 1, the oil phase components were heated to 70°C and dissolved, and the powder components were added and dispersed. The aqueous phase components, which had also been heated and dissolved at 70°C, were added to the oil phase, and emulsified while stirring with a homomixer to prepare a water-in-oil emulsion cosmetic. The obtained cosmetics were evaluated for the following items. The results are shown in Table 1.

[0072] (Non-sticky) An appropriate amount of the cosmetic product was applied to the skin, and a specialist evaluator scored the stickiness of the skin one minute after application according to the following criteria. 5 points: No sticky feeling 4 points: Almost no stickiness 3 points: Feels slightly sticky 2 points: Sticky feeling 1 point: Very sticky The average scores of the 10 evaluators were assigned to the following ratings. ◎: More than 4 points: Very good ○: More than 3 points and 4 points or less: Good △: More than 2 points, 3 points or less: slightly poor × : 2 points or less : Defective

[0073] (No creaking sensation) An appropriate amount of the cosmetic was applied to the skin, and the feeling of squeaking on the skin during application was scored by a specialist evaluator according to the following criteria. 5 points: No creaking sensation 4 points: Almost no creaking sensation 3 points: Slight creaking sensation 2 points: Creaking sensation 1 point: Very squeaky The average scores of the 10 evaluators were assigned to the following ratings. ◎: More than 4 points: Very good ○: More than 3 points and 4 points or less: Good △: More than 2 points, 3 points or less: slightly poor × : 2 points or less : Defective

[0074] (Moisturizing) An appropriate amount of the cosmetic product was applied to the skin, and the moist feeling of the skin one minute after application was scored by a specialist evaluator according to the following criteria. 5 points: Very moist feeling 4 points: Feels moist 3 points: Feels slightly moist 2 points: Almost no moist feeling 1 point: No moist feeling The average scores of the 10 evaluators were assigned to the following ratings. ◎: More than 4 points: Very good ○: More than 3 points and 4 points or less: Good △: More than 2 points, 3 points or less: slightly poor × : 2 points or less : Defective

[0075] (Stability of formulation) Each cosmetic product was placed in a standard glass bottle and stored in a thermostatic chamber set at 0°C for one month, after which a specialist evaluator visually evaluated the product on the following four-point scale. ◎: No crystal precipitation is observed ○: Very little crystallization is observed △: A small amount of crystals was observed. ×: Crystal precipitation is observed

[0076] [Table 1]

[0077] The cosmetic compositions of the examples containing components (A) and (B) were found to be excellent in terms of non-stickiness. Furthermore, they also had excellent usability, such as a non-squeaky feeling and a moist feeling (non-dry feeling), and excellent formulation stability, such as suppression of crystal precipitation. On the other hand, Comparative Example 1, which did not contain component (B), and Comparative Example 2, in which component (A) exceeded the specified range, had an insufficient feel when used.Furthermore, the stability of the preparation was also insufficient. [Industrial Applicability]

[0078] The present invention can be applied to external skin preparations, medicines, cosmetics including quasi-drugs, and the like.

Claims

1. The following components (A) and (B): (A) dipotassium glycyrrhizinate in an amount of 0.2 to 1.0% by mass based on the total amount of the sunscreen skin preparation, (B) ethylhexyl salicylate and / or tris(ethylhexyloxycarbonylanilinotriazine), A sunscreen for skin application containing the compound.

2. 2. The sunscreen topical skin preparation according to claim 1, comprising 0.1 to 15% by mass of component (B) based on the total mass of the sunscreen topical skin preparation.

3. 2. The sunscreen skin preparation according to claim 1, wherein the mass ratio of the contents of the components (A) and (B) ((B) / (A)) is 0.5 to 15.

4. 2. The sunscreen skin preparation according to claim 1, further comprising an ultraviolet scattering agent as component (C).

5. 5. The sunscreen for external use on skin according to claim 4, wherein the ultraviolet scattering agent of component (C) contains fine particle titanium dioxide and / or fine particle zinc oxide.

6. 5. The sunscreen composition for external use on the skin according to claim 4, wherein the ultraviolet scattering agent of component (C) has been subjected to a hydrophobizing treatment.

7. 5. The sunscreen topical skin preparation according to claim 4, comprising 0.01 to 15% by mass of component (C) based on the total mass of the sunscreen topical skin preparation.

8. 2. The sunscreen skin preparation according to claim 1, further comprising a component (D) an ultraviolet absorbing agent.

9. 9. The sunscreen skin preparation according to claim 8, wherein the ultraviolet absorbing agent of component (D) contains ethylhexyl methoxycinnamate and / or dimethylaminohydroxybenzoylhexyl benzoate.

10. 9. The sunscreen topical skin preparation according to claim 8, comprising 0.1 to 15 mass % of component (D) based on the total mass of the sunscreen topical skin preparation.

11. The following components (A) and (B): (A) dipotassium glycyrrhizinate in an amount of 0.2 to 1.0% by mass based on the total amount of the sunscreen skin preparation, (B) ethylhexyl salicylate and / or tris(ethylhexyloxycarbonylanilinotriazine), A method for producing a sunscreen topical skin preparation, comprising the step of blending

Images