Light irradiation device

Abstract

To provide a light irradiation device capable of suppressing damage to a light shield layer consisting of one or both of metal and metal oxide of an insertion body.SOLUTION: A light irradiation device includes an insertion body that can be inserted into a living body. The insertion body includes a light transmission layer that can transmit the light output inside to the outside, a light shield layer consisting of one or both of metal and metal oxide, and a protection layer formed of resin. The insertion body includes a light transmission window part where the light transmission layer is not covered with the light shield layer and a light shield part where the light transmission layer is covered with the light shield layer. The protection layer is stacked from outside in a radial direction at least in a part of the light shield layer of the light shield part.SELECTED DRAWING: Figure 1

Description

[Technical field]

[0001] The present disclosure relates to light illumination devices. [Background technology]

[0002] A light irradiation device used to irradiate abnormal tissue with therapeutic light is known. Patent Document 1 discloses this type of light irradiation device. The light irradiation device described in Patent Document 1 includes a balloon covered with a reflective coating, which can improve the efficiency and uniformity of light distribution in the treatment area. Patent Document 1 lists titanium dioxide, aluminum, gold, and silver as materials for the reflective coating. [Prior art documents] [Patent documents]

[0003] [Patent Document 2] Patent Publication 2005-46640 Summary of the Invention [Problem to be solved by the invention]

[0004] Patent Document 1 discloses an embodiment of a light irradiation device in which a balloon as an insert is coated with a reflective coating as a light shielding layer made of metal or metal oxide. A light shielding layer made of either or both of metal and metal oxide has low durability and may be damaged by sliding or expansion and contraction operations during a procedure. However, no solutions to these problems have been considered.

[0005] An object of the present disclosure is to provide a light irradiation device capable of suppressing damage to a light shielding layer made of either or both of a metal and a metal oxide of an insert. [Means for solving the problem]

[0006] A light irradiation device according to a first aspect of the present disclosure includes: (1) An insert that can be inserted into a living body, The insert comprises: a light transmitting layer capable of transmitting light emitted from inside to the outside; a light-shielding layer made of either or both of a metal and a metal oxide; A protective layer containing a resin, The insert comprises: a light-transmitting window portion in which the light-transmitting layer is not covered by the light-shielding layer; a light-shielding portion in which the light-transmitting layer is covered with the light-shielding layer, The protective layer is a light irradiation device that is laminated on at least a part of the light shielding layer of the light shielding portion from the outside in the radial direction.

[0007] A light irradiation device according to one embodiment of the present disclosure includes: (2) The light-illuminating device according to (1) above, wherein the light-shielding layer has a thickness of 1 μm or less.

[0008] A light irradiation device according to one embodiment of the present disclosure includes: (3) The light irradiation device according to the above (1) or (2), wherein the protective layer covers the entire area of ​​the light-shielding portion.

[0009] A light irradiation device according to one embodiment of the present disclosure includes: (4) The light irradiation device according to any one of (1) to (3) above, wherein the protective layer extends across the light-shielding portion and the light-transmitting window portion and covers the light-transmitting window portion.

[0010] A light irradiation device according to one embodiment of the present disclosure includes: (5) the protective layer has an outer edge portion covering the light-transmitting window portion, The light irradiation device according to (4) above, wherein the thickness of the outer edge portion is gradually decreased toward the outer edge.

[0011] A light irradiation device according to one embodiment of the present disclosure includes: (6) The light irradiation device according to any one of (1) to (5) above, wherein the insert is an expandable / contractable balloon.

[0012] A light irradiation device according to one embodiment of the present disclosure includes: (7) a tubular body that accommodates or defines an accommodation space capable of accommodating a light irradiator that emits the light; The light irradiation device according to (6) above, wherein the balloon covers the radial circumference of the tubular body.

[0013] A light irradiation device according to one embodiment of the present disclosure includes: (8) In the light irradiation device according to any one of (1) to (7) above, the protective layer has a lower light transmittance than the light transmitting layer.

[0014] A light irradiation device according to one embodiment of the present disclosure includes: (9) When the protective layer is a first protective layer, the insert includes a second protective layer having a higher light transmittance than the first protective layer; The light-illuminating device is described in (8) above, wherein the second protective layer is laminated on at least a portion of the first protective layer from the radially outer side and extends across the light-shielding portion and the light-transmitting window portion.

[0015] A light irradiation device according to one embodiment of the present disclosure includes: (10) The light irradiation device according to (9) above, wherein the second protective layer covers the entire area of ​​the first protective layer.

[0016] A light irradiation device according to one embodiment of the present disclosure includes: (11) In the light irradiation device according to the above (9) or (10), the second protective layer covers the entire area of ​​the light transmitting window portion.

[0017] A light irradiation device according to one embodiment of the present disclosure includes: (12) The light irradiation device according to any one of (1) to (11) above, further comprising an adhesive layer in the light shielding portion for bonding the light transmitting layer and the light shielding layer. Effect of the Invention

[0018] According to the present disclosure, it is possible to provide a light irradiation device capable of suppressing damage to a light shielding layer made of either or both of a metal and a metal oxide of an insert. [Brief description of the drawings]

[0019] [Figure 1] FIG. 1 is a diagram showing a light irradiation device according to an embodiment of the present disclosure. [Figure 2A] 2 is a diagram showing a state in which an insertion portion of the light irradiation device shown in FIG. 1 is inserted into a hollow organ. FIG. [Figure 2B] 2B is a diagram showing a state in which a balloon as an insert for the light irradiation device is expanded from the state shown in FIG. 2A. FIG. [Figure 2C] 2C is a diagram showing a state in which the light irradiator emits light and the target site is irradiated with light, following the state shown in FIG. 2B. FIG. [Diagram 3] 2 is a perspective view of the light irradiation device of FIG. 1, showing a state in which a balloon as an insert is expanded. FIG. [Figure 4] 4 is a plan view of the light irradiation device shown in FIG. 3 as viewed from the distal side in the axial direction. [Diagram 5] 2 is a plan view of the light irradiation device of FIG. 1 as seen from the distal axial direction, showing a state in which a balloon as an insert is deflated. FIG. [Figure 6] FIG. 4 is a cross-sectional view of FIG. [Figure 7] 1. FIG. 4 is a perspective view showing a modified example of the light irradiation device shown in FIG. [Figure 8]8 is a cross-sectional view taken along line bb in FIG. 7 . [Figure 9] 1. FIG. 4 is a cross-sectional view showing a modified example of the light irradiation device shown in FIG. [Figure 10] 1. FIG. 4 is a cross-sectional view showing a modified example of the light irradiation device shown in FIG. [Figure 11] 1. FIG. 4 is a cross-sectional view showing a modified example of the light irradiation device shown in FIG. [Figure 12] 1. FIG. 4 is a cross-sectional view showing a modified example of the light irradiation device shown in FIG. [Figure 13] 1. FIG. 4 is a cross-sectional view showing a modified example of the light irradiation device shown in FIG. [Figure 14] 1. FIG. 4 is a cross-sectional view showing a modified example of the light irradiation device shown in FIG. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0020] Hereinafter, a light irradiation device according to the present disclosure will be illustrated and described with reference to the drawings, in which the same components are denoted by the same reference numerals.

[0021] FIG. 1 is a diagram showing a light irradiation device 1 according to an embodiment of the present disclosure. The light irradiation device 1 can be used for, for example, photodynamic therapy (PDT) and photoimmunotherapy (PIT). In this embodiment, the light irradiation device 1 is used for photoimmunotherapy, which is taught in Japanese Patent No. 6127045, in which a drug adsorbed on a target cell is irradiated with light to destroy the target cell. The target cell is a tumor cell such as a cancer cell or a cell of a precancerous lesion. In this treatment method, a photosensitive substance is used as a drug, in which an antibody that specifically binds only to a specific antigen on the surface of the tumor cell and a photosensitive substance that pairs with the antibody are adsorbed. The antibody is not particularly limited, but examples thereof include panitumumab, trastuzumab, HuJ591, pertuzumab, lapatinib, palbociclib, and olaparib. The photosensitive substance is, for example, but not limited to, hydrophilic phthalocyanine, which is a substance (IR700) that reacts to near-infrared rays with a wavelength of about 700 nm. When IR700 is exposed to near-infrared rays with a wavelength of about 660 to 740 nm, the ligand of the functional group that ensures water solubility is broken, and a structural change occurs from water solubility to hydrophobicity. This structural change pulls out membrane proteins, opening holes in the cell membrane and allowing water to enter the cells, which can rupture and destroy tumor cells. In addition, IR700 is excited by receiving near-infrared rays and emits fluorescence with a wavelength different from the excitation wavelength. For example, when IR700 is excited by receiving near-infrared rays with a wavelength of about 690 nm, it emits fluorescence with a wavelength of about 700 nm. IR700 undergoes a structural change while emitting fluorescence due to a photoreaction, and when it destroys tumor cells and plays its role as a drug, it no longer emits fluorescence. More specifically, the light irradiation device 1 is inserted into a hollow organ 80 such as the digestive tract (esophagus, stomach, small intestine, large intestine, etc.), urinary tract, blood vessel, external auditory canal, Eustachian tube, nasal cavity, etc., and is used when irradiating abnormal tissue such as cancer tissue with light from within the hollow organ 80 in a living body. As will be described in detail later, the light irradiation device 1 of this embodiment can be inserted with a light irradiator 30 (see Figs. 2A to 2C). In the light irradiation device 1 of this embodiment, the inserted light irradiator 30 irradiates abnormal tissue with light, thereby performing phototherapy.

[0022] For ease of explanation, the longitudinal direction parallel to the central axis O of the light irradiation device 1 will be referred to as the "axial direction A". In addition, in the axial direction A of the light irradiation device 1, the side inserted into the living body will be referred to as the distal side, and the opposite side will be referred to as the proximal side. Furthermore, the direction around the central axis O of the light irradiation device 1 will be referred to as the "circumferential direction B". Furthermore, the radial direction of the circle around the central axis O of the light irradiation device 1 will be referred to as the "radial direction C".

[0023] As shown in FIG. 1, the light irradiation device 1 includes an insertion portion 1a and an operation portion 1b that is connected to the proximal side of the insertion portion 1a and extends outside the living body when the insertion portion 1a is inserted into the living body.

[0024] More specifically, the light irradiation device 1 of this embodiment includes a balloon 8 as an insert 2 that can be inserted into a living body, a tubular member 20, and a hub 40. The tubular member 20 extends from the proximal end to the distal end of the light irradiation device 1. The balloon 8 as the insert 2 is attached to the distal end of the tubular member 20. Although details will be described later, the tubular member 20 of this embodiment includes a first tubular body 21 and a second tubular body 22 that are concentrically arranged. The hub 40 is attached to the tubular member 20 and includes a port portion 40a to which a fluid supply tool can be connected. The operation portion 1b of this embodiment is composed of the hub 40 and a portion of the tubular member 20 that is located proximal to the insert 2. Here, the central axis O of the light irradiation device 1 of this embodiment is the central axis of the tubular member 20. In other words, the axial direction A of the light irradiation device 1 of this embodiment is the same as the direction parallel to the central axis of the tubular member 20. Moreover, the circumferential direction B of the light irradiation device 1 of this embodiment is the same as the direction around the central axis of the tubular member 20. Furthermore, the radial direction C of the light irradiation device 1 of this embodiment is the same as the radial direction of a circle around the central axis of the tubular member 20.

[0025] As described above, the tubular member 20 includes the first tubular body 21 and the second tubular body 22. As described above, the first tubular body 21 and the second tubular body 22 are arranged concentrically. The second tubular body 22 is arranged outside the first tubular body 21 in the radial direction C. The first tubular body 21 protrudes distally from the second tubular body 22. The first tubular body 21 protrudes proximally from the second tubular body 22. Furthermore, the first tubular body 21 of this embodiment protrudes proximally from the hub 40 connected to the proximal side of the second tubular body 22. However, the proximal end of the first tubular body 21 may terminate in the hub 40 as long as the light irradiator 30 can be inserted therein.

[0026] The first tubular body 21 of the present embodiment defines an accommodation space 21a capable of accommodating the light irradiator 30. In addition, an inflation lumen 22a capable of supplying a fluid such as air to the balloon 8 serving as the insertion body 2 is defined between the first tubular body 21 and the second tubular body 22 of the present embodiment. More specifically, the inflation lumen 22a is defined between the outer surface of the first tubular body 21 and the inner surface of the second tubular body 22.

[0027] The light irradiator 30 can emit light to the outside in the radial direction C. The light irradiator 30 of this embodiment has a light irradiating section 30a provided on the distal side of the light irradiator 30 in the axial direction A, and a light transmission member 30b such as an optical fiber connected to the light irradiating section 30a and extending to the proximal side in the axial direction A (see Figs. 2A to 2C). The light transmission member 30b transmits light from the light source device to the light irradiating section 30a. The light irradiating section 30a can emit light transmitted from the light source device via the light transmission member 30b to the outside in the radial direction C. The light irradiator 30 may be composed of, for example, a side-emitting optical fiber from which light is emitted all around to the outside in the radial direction C. The first tubular body 21 can transmit light emitted inside to the outside. More specifically, the first tubular body 21 can transmit light from the light irradiator 30 accommodated in the accommodation space 21a toward the outside in the radial direction C of the first tubular body 21. The first tubular body 21 is made of a light-transmitting material that can transmit light, and may be made of, for example, a transparent resin material. The first tubular body 21 may have, for example, an opening that allows light to pass through.

[0028] The material for forming the first tubular body 21 and the second tubular body 22 of the tubular member 20 is not particularly limited, and may be, for example, a resin material. Examples of the resin material for forming the first tubular body 21 and the second tubular body 22 include polyolefins such as polyethylene, polypropylene, and ethylene-propylene copolymers; ethylene-vinyl acetate copolymers (EVA); polyvinyl chloride; polyvinylidene chloride; polystyrene; polyamide; polyimide; polyamideimide; polycarbonate; poly-(4-methylpentene-1); ionomers; acrylic resins; polymethyl methacrylate; acrylonitrile-butadiene-styrene copolymers (ABS resins); acrylonitrile-styrene copolymers (AS resins); butadiene-styrene copolymers; polyethylene. Examples of the resin materials include polyesters such as polyethylene terephthalate (PET), polybutylene terephthalate (PBT), and polycyclohexane terephthalate (PCT); polyether; polyether ketone (PEK); polyether ether ketone (PEEK); polyetherimide; polyacetal (POM); polyphenylene oxide; modified polyphenylene oxide; polysulfone; polyether sulfone; polyphenylene sulfide; polyarylate; aromatic polyester (liquid crystal polymer); polytetrafluoroethylene, polyvinylidene fluoride, and other fluorine-based resins. The second tubular body 22 may also be a blend containing one or more of these. The second tubular body 22 may also be a metal such as stainless steel, iron, nickel-titanium alloy, and aluminum. The second tubular body 22 may also have a structure such as a braided tube in which a reinforcing material made of braided metal wire is embedded in a resin tube, a catheter reinforced with a metal coil, or a hypotube.

[0029] The light irradiator 30 accommodated in the accommodation space 21a is inserted to a position in the insert 2 in the axial direction A. Specifically, in this embodiment, the light irradiator 30 is inserted into the accommodation space 21a until the light irradiating portion 30a is positioned in the insert 2 in the axial direction A. As shown in FIG. 1, the distal end of the accommodation space 21a in this embodiment is closed. More specifically, a blocking member 25 is disposed inside the distal end portion of the first tubular body 21 in this embodiment. The distal end of the accommodation space 21a is blocked by the blocking member 25. The light irradiator 30 is inserted into the accommodation space 21a to a position where the light irradiating portion 30a abuts against the blocking member 25. In this manner, in this embodiment, the light irradiating portion 30a of the light irradiator 30 can be disposed at a predetermined position in the balloon 8 as the insert 2.

[0030] The light irradiation device 1 of the present embodiment does not include the light irradiator 30. That is, the light irradiation device 1 of the present embodiment is used together with the light irradiator 30 separately accommodated in the accommodation space 21a of the first tubular body 21. However, the light irradiation device 1 may include the light irradiator 30. In this case, the light irradiator 30 may be integrated with the light irradiation device 1 by being accommodated in the accommodation space 21a and fixed to the first tubular body 21.

[0031] The insert 2 of this embodiment is a balloon 8 that can expand and contract. The balloon 8 as the insert 2 of this embodiment covers the circumference of the first tubular body 21 in the radial direction C. More specifically, the balloon 8 as the insert 2 is an endless membrane body that covers the entire area of ​​the first tubular body 21 in the circumferential direction B outside the radial direction C of the first tubular body 21. The distal end of this membrane body is joined to the distal end of the first tubular body 21 by adhesion or the like over the entire area of ​​the circumferential direction B. In addition, the proximal end of this membrane body is joined to the distal end of the second tubular body 22 by adhesion or the like over the entire area of ​​the circumferential direction B. The distal end and proximal end of the membrane body are not joined to the first tubular body 21, and an annular space 5 capable of accommodating a fluid is defined between the first tubular body 21 and the distal end. The distal opening of the inflation lumen 22a defined between the first tubular body 21 and the second tubular body 22 communicates with this annular space 5.

[0032] When fluid is supplied to the annular space 5 through the inflation lumen 22a, the balloon 8 as the insert body 2 expands outward in the radial direction C. Conversely, when fluid is discharged from the annular space 5 through the inflation lumen 22a, the balloon 8 as the insert body 2 contracts inward in the radial direction C.

[0033] FIG. 3 is a perspective view of the light irradiation device 1 showing a state in which the balloon 8 as the insertion body 2 is expanded. FIG. 4 is a plan view of the light irradiation device 1 shown in FIG. 3 seen from the distal side in the axial direction A. As shown in FIG. 3 and FIG. 4, the balloon 8 as the insertion body 2 of this embodiment includes a tube wall portion 2a that is substantially cylindrical in the expanded state, a proximal wall portion 2b that is continuous with the proximal side of the tube wall portion 2a, and a distal wall portion 2c that is continuous with the distal side of the tube wall portion 2a. The proximal wall portion 2b is reduced in diameter toward the proximal side. The distal wall portion 2c is reduced in diameter toward the distal side. FIG. 5 is a plan view of the light irradiation device 1 seen from the distal side in the axial direction A showing a state in which the balloon 8 as the insertion body 2 is contracted. As shown in FIG. 5, the balloon 8 as the insertion body 2 of this embodiment, in a contracted state, includes a plurality of pleats 50 protruding outward in the radial direction C, and a folded portion 51 connecting the base ends of two adjacent pleats 50 in the circumferential direction B. In this embodiment, four pleats 50 are formed so as to be aligned in the circumferential direction B. The balloon 8 in the contracted state of this embodiment is inserted into and removed from a living body in a wrapped state in which the pleats 50 are wrapped around the first tubular body 21. In this manner, the wrapping diameter, which is the diameter of the balloon 8 in the wrapped state, can be reduced. However, the shapes of the balloon 8 as the insertion body 2 in the expanded and contracted states are not limited to the above configurations.

[0034] The insert 2 includes a light-transmitting window portion 3 that can transmit light from the light irradiator 30 accommodated in the accommodation space 21a. Although details will be described later, the light-transmitting window portion 3 of this embodiment is formed in the cylindrical wall portion 2a over the entire area in the circumferential direction B of the insert 2.

[0035] As described above, the insert 2 of the present embodiment is an expandable and contractible balloon 8, but is not limited to this configuration. The insert 2 may not be configured to be expandable and contractible, for example. However, since the insert 2 is an expandable and contractible balloon, the light-transmitting window portion 3 can be easily brought into close contact with the target site X from inside the tubular organ 80 as the inside of the living body. This can increase the efficiency of light irradiation to the target site X. In addition, the light irradiation device 1 may not include the first tubular body 21. The insert 2 may be, for example, a tube that defines a hollow portion into which the light irradiator 30 can be inserted and has the light-transmitting window portion 3 provided on a part of the side wall. However, particularly when the insert 2 is a balloon, the light irradiation device 1 includes the first tubular body 21, so that the position of the light irradiator 30 in the axial direction A and the radial direction C can be stabilized.

[0036] As shown in Fig. 1, a hub 40 is attached to the proximal end of the second tubular body 22 of the tubular member 20 of this embodiment. The hub 40 has a port portion 40a to which a liquid supplying tool such as a syringe can be connected. A liquid or gas can be supplied as a fluid to the annular space 5 of the balloon 8 as the insert 2 through the inflation lumen 22a by the fluid supplying tool connected to the port portion 40a. Moreover, the hub 40 of this embodiment defines a through hole 40b through which the first tubular body 21 is inserted.

[0037] Next, an example of a treatment method using the light irradiation device 1 will be described with reference to Figs. 2A to 2C. In this example, a treatment in a tubular organ 80 as an in vivo body is targeted. First, a photosensitive substance as a drug is administered to a patient, and the photosensitive substance is adsorbed in cancer tissue. In the procedure, first, the light irradiator 30 is inserted into the accommodation space 21a of the first tubular body 21 from the proximal end side of the light irradiation device 1 (see Fig. 2A). At this time, the light irradiating section 30a of the light irradiator 30 is inserted in the axial direction A to the position where the inserting body 2 is provided. Next, the inserting section 1a of the light irradiation device 1 is inserted into the tubular organ 80 together with the light irradiator 30 (see Fig. 2A). When the inserting section 1a is inserted into the tubular organ 80, the balloon 8 as the inserting body 2 is in a contracted state. Then, the light transmission window section 3 of the balloon 8 is aligned with the target site X. Then, the balloon 8 is expanded to an expanded state (see Fig. 2B). Thereafter, the light irradiator 30 irradiates the target site X with light through the peripheral wall of the first tubular body 21 and the light-transmitting window portion 3 provided in the balloon 8 (see FIG. 2C). Thereafter, the balloon 8 is deflated, and the insertion portion 1a is pulled out from inside the hollow organ 80.

[0038] In the above-mentioned procedure, for example, the insertion portion 1a of the light irradiation device 1 may be moved in the axial direction A to irradiate the target site X with light in multiple separate steps in the axial direction A. Here, from the viewpoint of load on the tubular organ 80 including the target site X and operability, it is desirable that the balloon 8 as the insertion body 2 be in a contracted state when the insertion portion 1a is moved within the tubular organ 80. In other words, the balloon 8 as the insertion body 2 may be repeatedly expanded and contracted multiple times during the treatment.

[0039] Next, further details of the insert 2 will be described. FIG. 6 is a cross-sectional view of FIG. 3 taken along line aa. As shown in FIG. 1 and FIG. 6, the film body forming the insert 2 includes a light-transmitting layer 10, a light-shielding layer 11, and a protective layer 12. The light-shielding layer 11 covers the light-transmitting layer 10. More specifically, the light-shielding layer 11 is laminated on the light-transmitting layer 10 from the outside in the radial direction C. In other words, the insert 2 includes a film body formed of the light-transmitting layer 10 and the light-shielding layer 11 made of a coating material coated on the outside of the light-transmitting layer 10 in the radial direction C. The protective layer 12 covers the light-shielding layer 11. More specifically, the protective layer 12 is laminated on at least a part of the light-shielding layer 11 from the outside in the radial direction C. That is, the protective layer 12 may cover the entire area of ​​the light-shielding portion 4 up to the boundary between the light-transmitting window portion 3 and the light-shielding portion 4 or beyond this boundary to the light-transmitting window portion 3.

[0040] The light transmitting layer 10 can transmit light emitted from inside to the outside. Specifically, the light transmitting layer 10 can transmit light from the light irradiator 30 accommodated in the accommodation space 21a of the first tubular body 21 to the outside in the radial direction C. Here, the light from the light irradiator 30 is appropriately selected depending on the treatment, and may be visible light such as near infrared light. The light transmitting layer 10 is formed of a light transmitting material. Specifically, examples of materials for forming the light transmitting layer 10 include resin materials such as polyethylene terephthalate, polyurethane, polyamide, and nylon.

[0041] The light-shielding layer 11 is made of either or both of a metal and a metal oxide. The light-shielding layer 11 is less likely to transmit light from the light irradiator 30 than the light-transmitting layer 10. More specifically, the light-shielding layer 11 has a lower transmittance of light from the light irradiator 30 than the light-transmitting layer 10. Specifically, examples of materials for forming the light-shielding layer 11 include aluminum, silver, gold, titanium, nickel, copper, aluminum oxide, titanium oxide, barium sulfate, and zinc oxide. The light-shielding layer 11 may also be a blend containing one or more of these. The light-shielding layer 11 may also be a laminate consisting of multiple layers containing one or more of these. By making the light-shielding layer 11 a blend or a laminate consisting of multiple layers, it is possible to appropriately shield light according to the treatment.

[0042] The insert 2 of the light irradiation device 1 may be inserted into a forceps channel of an endoscope or the like to be used as an endoscope system. In order to facilitate insertion into a forceps channel of an endoscope or the like, it is preferable that the thickness of the laminate laminated on the light transmission layer 10 is small. Therefore, it is preferable that the thickness of the light shielding layer 11 is also small. Specifically, it is preferable that the thickness of the light shielding layer 11 is 1 μm or less. It is more preferable that the thickness of the light shielding layer 11 is 300 nm or less. It is even more preferable that the thickness of the light shielding layer 11 is 200 nm or less. On the other hand, in order to sufficiently shield light, it is preferable to ensure a certain degree of thickness of the laminate laminated on the light transmission layer 10. For example, the thickness of the light shielding layer 11 may be 150 nm or more. The light shielding layer 11 may be formed, for example, by a vapor deposition method. The vapor deposition method is a method of forming a thin film on a target surface by heating and evaporating a metal or the like. However, the method of forming the light shielding layer 11 is not limited thereto. The light-shielding layer 11 may be formed, for example, by coating the surface of the light-transmitting layer 10. The coating method is not particularly limited, and for example, a dipping method, a spray coating method, a roll coating method, a screen printing method, or the like may be used. However, according to the deposition method, both sides of the light-shielding layer 11 can be mirror-finished to increase the reflectance, and a part of the light emitted from the light irradiator 30 can be reflected and emitted to the outside in the radial direction C through the light-transmitting window portion 3. This allows the light irradiation by the light irradiation device 1 to be performed more efficiently, and the light-shielding layer 11 having a thickness of 1 μm or less can be easily formed.

[0043] As shown in FIG. 1, FIG. 3, FIG. 6, etc., the insert 2 includes a light-transmitting window 3 and a light-shielding portion 4. The light-transmitting window 3 is a portion where the light-transmitting layer 10 is not covered by the light-shielding layer 11. The light-shielding portion 4 is a portion where the light-transmitting layer 10 is covered by the light-shielding layer 11. The light-transmitting window 3 allows the light of the light irradiator 30 accommodated in the accommodation space 21a of the first tubular body 21 to transmit to the outside. On the other hand, in the light-shielding portion 4, the light-transmitting layer 10 is covered by the light-shielding layer 11, so that the light of the light irradiator 30 accommodated in the accommodation space 21a is less likely to transmit to the outside than the light-transmitting window 3. More specifically, the light-shielding portion 4 has a smaller transmittance of light of the light irradiator 30 accommodated in the accommodation space 21a than the light-transmitting window 3.

[0044] As shown in FIG. 3 and FIG. 6, the insert 2 of this embodiment includes a light-transmitting window portion 3 extending over the entire area in the circumferential direction B. The light-shielding portion 4 is disposed at both ends of the balloon 8, which are adjacent to the light-transmitting window portion 3 in the axial direction A. The insert 2 of this embodiment includes the light-shielding portion 4 except for the portion in which the light-transmitting window portion 3 is formed. Therefore, the light of the light irradiator 30 emitted inside the insert 2 and the first tubular body 21 passes through the first tubular body 21 and is irradiated toward the outside in the radial direction C of the insert 2 through the light-transmitting window portion 3 formed in a part of the insert 2. Conversely, at the position of the light-shielding portion 4, the intensity of the light of the light irradiator 30 irradiated toward the outside in the radial direction C of the insert 2 is smaller than the intensity of the light of the light irradiator 30 irradiated by the light-transmitting window portion 3. In this way, the insert 2 includes the light-transmitting window portion 3 capable of irradiating light toward the outside in the radial direction C as a part of the insert 2, so that the light irradiation by the light irradiation device 1 can be clearly recognized by the surgeon.

[0045] The light-transmitting window 3 of this embodiment is formed in the tube wall 2a over the entire area in the circumferential direction B of the insert 2. However, the area in which the light-transmitting window 3 is formed is not limited to this area. The light-transmitting window 3 may be formed, for example, from the tube wall 2a to the distal wall 2c. Also, the light-transmitting window 3 may be formed, for example, from the tube wall 2a to the proximal wall 2b.

[0046] FIG. 7 is a perspective view showing a modified example of the light irradiation device 1. FIG. 8 is a cross-sectional view taken along the line bb in FIG. 7. As shown in FIGS. 7 and 8, the balloon 8 as the insert 2 may have a light-transmitting window portion 3 only in a part of the circumferential direction B. This allows the light irradiation range of the light irradiation device 1 to be limited to a part of the circumferential direction B. In this case, a part of the light emitted from the light irradiator 30 is reflected by the light-shielding layer 11 made of either or both of a metal and a metal oxide in the light-shielding portion 4, and is emitted to the outside in the radial direction C through the light-transmitting window portion 3. This allows the light irradiation by the light irradiation device 1 to be performed more efficiently.

[0047] The protective layer 12 contains a resin. More specifically, the protective layer 12 is a sheet-like member containing a resin and has flexibility. As described above, the protective layer 12 covers the light-shielding layer 11. By being covered with the protective layer 12, the light-shielding layer 11 is less likely to be subjected to external forces due to sliding when moving within a living body, when moving within an insertion hole of a medical instrument such as a forceps channel of an endoscope used together, etc. As a result, damage to the light-shielding layer 11 can be suppressed. The protective layer 12 of this embodiment covers the entire area of ​​the light-shielding layer 11. By covering the entire area of ​​the light-shielding layer 11 with the protective layer 12, damage to the light-shielding layer 11 can be suppressed over a wider area than when the protective layer 12 covers only a part of the light-shielding layer 11.

[0048] As described above, the light-shielding layer 11 is made of either or both of a metal and a metal oxide. The light-shielding layer 11 made of either or both of a metal and a metal oxide can be formed as a thin film of, for example, 1 μm or less by a deposition method or the like, but tends to be easily damaged by an external force. However, in the light irradiation device 1 of the present embodiment, the light-shielding layer 11 is covered with a protective layer 12, so that damage to the light-shielding layer 11 can be suppressed. In addition, by making the protective layer 12 out of a material having a light-shielding property, it becomes possible to shield light that could not be completely shielded by the light-shielding layer 11 with a higher light-shielding rate.

[0049] The protective layer 12 may have a transmittance of the light of the light irradiator 30 equal to or greater than that of the light transmission layer 10. However, it is preferable that the protective layer 12 has a smaller transmittance of the light of the light irradiator 30 than that of the light transmission layer 10. More specifically, the protective layer 12 may have a smaller transmittance of the light of the light irradiator 30 than that of the light transmission layer 10 by being formed by adding a shielding material to a resin. Specifically, the shielding material is carbon black powder or the like. When the insert 2 is an expandable and contractible balloon 8, the light shielding layer 11 of a thin film made of either or both of a metal and a metal oxide is easily damaged by the expansion and contraction of the balloon 8. Specifically, when the balloon 8 as the insert 2 is contracted from an expanded state, and when it is contracted and then re-expanded, cracks may occur in the light shielding layer 11. In particular, cracks are likely to occur at the folded portion 51 formed in the contracted state of the balloon 8. If light is emitted from the light irradiator 30 while a crack is occurring in the light-shielding layer 11, light may leak from the crack and be irradiated to a site other than the target site X (see FIGS. 2A to 2C). It is preferable that the light irradiation device 1 not irradiate normal tissue other than the target site X with light as much as possible. In contrast, by making the transmittance of the protective layer 12 smaller than that of the light-transmitting layer 10, the light leaking from the crack can be blocked by the protective layer 12. In this way, by providing the insertion body 2 with both the light-shielding layer 11 and the protective layer 12 having a light transmittance smaller than that of the light-transmitting layer 10, it is possible to make it difficult for light to be irradiated to a site other than the target site X.

[0050] 9 to 14 are cross-sectional views showing modified examples of the light irradiation device 1. The balloon 8 as the insert 2 in the light irradiation device 1 shown in FIG. 9 to FIG. 14 has a light-transmitting window portion 3 only in a part of the circumferential direction B, similar to the modified examples shown in FIG. 7 and FIG. 8. The positions of the cutting lines in the cross-sectional views of FIG. 9 to FIG. 14 are the same as those in the cross-sectional view of FIG. 8. In the modified example shown in FIG. 9, the protective layer 12 extends across the light-shielding portion 4 and the light-transmitting window portion 3, and covers the light-transmitting window portion 3 in addition to the light-shielding portion 4. At this time, the protective layer 12 covers the light-shielding layer 11 and the light-transmitting layer 10 in a manner in which the protective layer 12 is in close contact with each of them. In this way, the end face in the circumferential direction B of the light-shielding layer 11 can be covered with the protective layer 12. That is, the end face in the circumferential direction B of the light-shielding layer 11 can be prevented from being exposed. This can prevent the light-shielding layer 11 from peeling off from the end face in the circumferential direction B.

[0051] In addition, resin and metal, and resin and metal oxide generally tend not to adhere to each other. Therefore, when the light-transmitting layer 10 is made of a resin material and the protective layer 12 covers only the light-shielding layer 11, the light-shielding layer 11 made of either or both of metal and metal oxide may peel off from the light-transmitting layer 10 made of a resin material due to an external force caused by the sliding of the insert 2. On the other hand, as in the modified example shown in FIG. 9, the protective layer 12 is laminated on the light-transmitting layer 10 constituting the light-transmitting window portion 3 in addition to the light-shielding layer 11, and a portion is provided where the light-transmitting layer 10 made of a resin material and the protective layer 12 containing resin are in contact with each other, thereby preventing the light-shielding layer 11 from peeling off from the insert 2. In the modified example shown in FIG. 9, the protective layer 12 has an outer edge portion 12a including an outer edge end 12a1 that covers the light-transmitting window portion 3, but may not have the outer edge portion 12a. In particular, when the protective layer 12 has a transmittance equal to or greater than that of the light transmitting layer 10, the protective layer 12 may be an endless layer in the circumferential direction B. In this way, the protective layer 12 does not have an end face in the circumferential direction B, and peeling of the protective layer 12 in the circumferential direction B can be suppressed.

[0052] In the modification shown in FIG. 10, the protective layer 12 extends across the light-shielding portion 4 and the light-transmitting window portion 3, and the thickness of the outer edge portion 12a of the protective layer 12 that covers the light-transmitting window portion 3 gradually decreases toward the outer edge end 12a1. The protective layer 12 covers the light-shielding layer 11 and the light-transmitting layer 10 in a manner that adheres closely to each other. Since the protective layer 12 extends across the light-shielding portion 4 and the light-transmitting window portion 3 and forms the outer edge portion 12a of the protective layer 12 that covers the light-transmitting window portion 3, it is possible to suppress the light-shielding layer 11 from peeling off from the light-transmitting layer 10, as in the modification shown in FIG. 9. Furthermore, since the thickness of the outer edge portion 12a gradually decreases toward the outer edge end 12a1, the external force applied to the outer edge portion 12a due to the sliding of the insert 2 can be reduced compared to a case in which the thickness of the outer edge portion 12a does not gradually decrease toward the outer edge end 12a1. As a result, peeling of the outer edge portion 12a of the protective layer 12 from the light transmitting layer 10 and peeling of the light shielding layer 11 together with the outer edge portion 12a of the protective layer 12 from the light transmitting layer 10 can be suppressed more effectively than in the case where the thickness of the outer edge portion 12a does not gradually decrease toward the outer edge end 12a1.

[0053] In the modified example shown in FIG. 11, the insert 2 includes, in addition to the configuration shown in FIG. 8, another protective layer that further covers the protective layer 12 that covers the light-shielding layer 11. For convenience of explanation, the protective layer 12 that covers the light-shielding layer 11 is referred to as the first protective layer 12, and the protective layer that further covers the first protective layer 12 is referred to as the second protective layer 14. The first protective layer 12 shown in FIG. 11 is less likely to transmit the light of the light irradiator 30 than the light-transmitting layer 10. More specifically, the first protective layer 12 is formed by adding a shielding material to a resin, and the light transmittance of the light irradiator 30 is smaller than that of the light-transmitting layer 10. In contrast, the second protective layer 14 is made of a transparent material, and the light transmittance of the light irradiator 30 is larger than that of the first protective layer 12. The material forming the second protective layer 14 may be the same as the material forming the light-transmitting layer 10 described above.

[0054] As shown in FIG. 11, the first protective layer 12 covers the light-shielding layer 11 in the light-shielding portion 4, but is not provided in the region of the light-transmitting window portion 3. In other words, the first protective layer 12 covers only the light-shielding portion 4. As described above, the first protective layer 12 contains a shielding material, and the light transmittance of the light irradiator 30 is smaller than that of the light-transmitting layer 10. Therefore, when the first protective layer 12 is provided in the light-transmitting window portion 3, the efficiency of light irradiation in the light-transmitting window portion 3 may decrease. To avoid this, the first protective layer 12 covers only the light-shielding portion 4. In contrast, the second protective layer 14 extends across the light-shielding portion 4 and the light-transmitting window portion 3. That is, the second protective layer 14 covers the light-transmitting window portion 3 in addition to the light-shielding portion 4. This is because the second protective layer 14 has a higher light transmittance for the light irradiator 30 than the first protective layer 12, and is less likely to reduce the efficiency of light irradiation at the light-transmitting window portion 3 even when provided in the light-transmitting window portion 3.

[0055] In the modification shown in FIG. 11, the second protective layer 14 extends across the light-shielding portion 4 and the light-transmitting window portion 3, so that the light-shielding layer 11 can be prevented from peeling off from the light-transmitting layer 10, as in the modification shown in FIG. 9 and FIG. 10. That is, the second protective layer 14 is laminated from the outside in the radial direction C (toward the outside in the radial direction C) on the first protective layer 12 covering the light-shielding portion 4 and on at least a part of the light-transmitting layer 10 in the light-transmitting window portion 3, and a portion where the light-transmitting layer 10 and the second protective layer 14 are in contact with each other is provided, so that the light-shielding layer 11 and the first protective layer 12 can be prevented from peeling off from the light-transmitting layer 10. Note that the second protective layer 14 may be laminated from the outside in the radial direction C on at least a part of the light-transmitting layer 10 in the light-transmitting window portion 3 so as to cover at least the end face (outer edge portion) of the light-shielding layer 11 and the end face (outer edge portion) of the first protective layer 12.

[0056] 12, the second protective layer 14 extends across the light-shielding portion 4 and the light-transmitting window portion 3, and covers the entire light-shielding portion 4. In the modification shown in Fig. 12, since the second protective layer 14 covers the entire light-shielding portion 4, in addition to the effect obtained in the modification shown in Fig. 11, the entire light-shielding layer 11 of the light-shielding portion 4 and the first protective layer 12 laminated on the light-shielding portion 4 can be protected by the second protective layer 14. Therefore, the light-shielding layer 11 of the light-shielding portion 4 and the first protective layer 12 laminated on the light-shielding portion 4 can be prevented from peeling off.

[0057] In the modification shown in FIG. 13, the second protective layer 14 made of a light-transmitting material extends across the light-shielding portion 4 and the light-transmitting window portion 3, and covers the entire area of ​​each of the light-transmitting window portion 3 and the light-shielding portion 4. Since the second protective layer 14 covers the entire area of ​​the light-transmitting window portion 3, the outer edge of the second protective layer 14 is not formed on the light-transmitting window portion 3. Therefore, in the modification shown in FIG. 13, in addition to the effect obtained in the modification shown in FIG. 12, the second protective layer 14 can be prevented from peeling off starting from the outer edge on the light-transmitting window portion 3. As a result, the light-shielding layer 11 of the light-shielding portion 4 and the first protective layer 12 laminated on the light-shielding portion 4 can be prevented from peeling off together with the second protective layer 14. In particular, as shown in FIG. 13, the second protective layer 14 is preferably an endless layer in the circumferential direction B. In this manner, the second protective layer 14 does not have an end surface in the circumferential direction B, and peeling of the second protective layer 14 in the circumferential direction B can be further suppressed.

[0058] In the modification shown in FIG. 14, the light irradiation device 1 includes an adhesive layer 18 that bonds the light transmitting layer 10 and the light shielding layer 11 in the light shielding portion 4. In other words, the light transmitting layer 10 and the light shielding layer 11 are connected in the radial direction C via the adhesive layer 18 provided between them. The adhesive layer 18 is formed of a material that easily adheres to any of metals, metal oxides, and resins. Specifically, examples of the material for forming the adhesive layer 18 include synthetic resins such as cyanoacrylate and epoxy resin. However, the material for forming the adhesive layer 18 is not limited thereto. In this way, by providing the adhesive layer 18 between the light transmitting layer 10 and the light shielding layer 11, it is possible to suppress the light shielding layer 11 from peeling off from the light transmitting layer 10. The adhesive layer 18 may have a thickness of, for example, 1 μm. It is preferable that the adhesive layer 18 has a thickness that provides a rigidity that allows the balloon 8 to expand and contract.

[0059] The light irradiation device according to the present disclosure is not limited to the specific configurations shown in the above-mentioned embodiments and modifications, and various modifications, changes, and combinations are possible without departing from the scope of the claims. For example, in the modification shown in Fig. 14, in addition to the light shielding layer 11, the protective layer 12 may be laminated directly or via an adhesive layer 18 on the light transmitting layer 10 constituting the light transmitting window portion 3, and the light transmitting layer 10 made of a resin material and the protective layer 12 containing resin may be provided at a location where they are in contact with each other, thereby preventing the light shielding layer 11 from peeling off from the insert 2. [Industrial Applicability]

[0060] The present disclosure relates to light illumination devices. [Explanation of symbols]

[0061] 1: Light irradiation device 1a: Insertion section 1b: Operation section 2: Insert 2a: Cylinder wall part 2b: Proximal wall 2c: Distal wall 3: Light-transmitting window 4: Shading section 5: Annular space 8: Balloon 10: Light transmission layer 11: Light shielding layer 12: Protective layer (1st protective layer) 12a: Outer edge 12a1:Outer edge 14:Second protective layer 18: Adhesive layer 20: Tubular member 21: First tubular body 21a: Containment space 22:Second tubular body 22a: Inflation lumen 25: Closure member 30: Light emitting body 30a: Light irradiation part 30b: Optical transmission component 40: Hub 40a: Port section 40b: Through hole 50: Folds 51: Folding section 80: Luminal organs A: Axial direction of the light irradiation device (axial direction along the central axis of the tubular member) B: Circumferential direction of the light irradiation device (circumferential direction around the central axis of the tubular member) C: Radial direction of the light irradiation device (radial direction of a circle around the central axis of the tubular member) O: central axis of tubular member X: Target area

Claims

1. An insert that can be inserted into a living body, The insert comprises: a light transmitting layer capable of transmitting light emitted from inside to the outside; a light-shielding layer made of either or both of a metal and a metal oxide; A protective layer containing a resin, The insert comprises: a light-transmitting window portion in which the light-transmitting layer is not covered by the light-shielding layer; a light-shielding portion in which the light-transmitting layer is covered with the light-shielding layer, The protective layer is laminated on at least a part of the light-shielding layer of the light-shielding portion from the outside in the radial direction. Light emitting device.

2. The light-illuminating device according to claim 1 , wherein the light-shielding layer has a thickness of 1 μm or less.

3. The light irradiation device according to claim 1 , wherein the protective layer covers an entire area of ​​the light shielding portion.

4. The light irradiation device according to claim 1 , wherein the protective layer extends across the light-shielding portion and the light-transmitting window portion and covers the light-transmitting window portion.

5. the protective layer has an outer edge portion covering the light-transmitting window portion, The light emitting device according to claim 4 , wherein the outer periphery has a gradually decreasing thickness towards the outer edge.

6. The light irradiation device according to claim 1 or 2, wherein the insert is an expandable / contractable balloon.

7. a tubular body that accommodates or defines an accommodation space capable of accommodating a light irradiator that emits the light; The light irradiation device according to claim 6 , wherein the balloon covers a radial circumference of the tubular body.

8. The light irradiation device according to claim 1 , wherein the protective layer has a lower light transmittance than the light transmitting layer.

9. When the protective layer is a first protective layer, the insert includes a second protective layer having a higher light transmittance than the first protective layer; The light illumination device according to claim 8 , wherein the second protective layer is laminated on at least a part of the first protective layer from a radially outer side and extends across the light-shielding portion and the light-transmitting window portion.

10. The light irradiation device according to claim 9 , wherein the second protective layer covers the entire area of ​​the first protective layer.

11. The light illumination device according to claim 9 , wherein the second protective layer covers an entire area of ​​the light-transmitting window portion.

12. The light irradiation device according to claim 1 , wherein the light shielding portion comprises an adhesive layer that bonds the light transmitting layer and the light shielding layer.

Images