Cosmetical use of topically applicable rinse-of composition (RC)

Abstract

To provide care products suitable for hair loss reduction in combination with improving hair structure, comprising increasing the diameter or cross-section of hair or improving keratin expression.SOLUTION: The present invention relates to the cosmetic use of a topically applicable rinse-off composition (RC) comprising as components (A) sandal pentanol (3-methyl-5-(2,2,3-trimethylcyclopent-3-en-1-yl)pentan-2-ol) and / or one or more sandal pentanol analog(s), (B) caffeine, (C) at least one C10-C18 fatty acid and / or salts thereof, (D) at least one surfactant, and (E) at least one cosmetically acceptable solvent for (i) improving hair structure, and (ii) hair loss reduction. In another aspect, the present invention relates to a non-therapeutic method for (i) improving hair structure, and (ii) hair loss using the topically applicable rinse-off composition (RC).SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to the cosmetic use of a locally applicable rinse-off composition (RC) for (i) improving hair structure and (ii) reducing hair loss, comprising as components (A) sandal pentanol (3-methyl-5-(2,2,3-trimethylcyclopent-3-en-1-yl)pentan-2-ol) and / or one or more sandal pentanol analogs, (B) caffeine, (C) at least one C10-C18 fatty acid and / or their salts, (D) at least one surfactant, and (E) at least one cosmetically acceptable solvent. In another aspect, the present invention relates to a non-therapeutic method for (i) improving hair structure and (ii) reducing hair loss using a locally applicable rinse-off composition (RC).

Background Art

[0002] Human hair growth occurs in a known manner according to a natural growth rhythm including anagen (growth phase), catagen (transition phase), telogen (resting phase), and exogen (shedding phase). The normal natural hair cycle begins when the hair root falls out before the shedding phase or the start of a new growth phase. During the anagen phase, the cells of the hair root divide rapidly and new hair is formed. The typical growth rate of scalp hair is about 0.3-0.4 millimeters per day. The anagen phase lasts about 2-6 years. The catagen phase following the anagen phase means a short transition period in which hair growth stops and the blood supply to the cells promoting hair growth is cut off. The catagen phase lasts about 10 days. The telogen phase lasts about 100 days, during which individual hairs remain in the hair follicle but stop active growth. Finally, in the exogen phase, individual hairs are shed or released. The exogen phase lasts about 2-5 months.

[0003] During normal hair growth, 80 to 100 hairs fall out from the scalp per day. This number is an approximate value, which may occur in a shorter period, and may be more or less, but it does not cause concerns regarding natural hair growth. However, if the amount of hair falling out per day exceeds this approximate normal amount, irreversible or reversible hair loss is occurring.

[0004] International Application No. 2022 / 112419 discloses a composition comprising sandal pentanol, caffeine, and one or more C10 - C18 fatty acids. This composition can be used for reducing hair loss.

[0005] As the volume of hair is lost over time, it is generally recognized as "thinning hair", but such a decrease in volume can be caused by various phenomena. One obvious reason for feeling hair thinning is hair loss, that is, a decrease in the number or areal density of hair follicles that produce hair. Another reason for feeling hair thinning is a change in the growth cycle. For example, when the proportion of hair in the growth phase and the duration of the growth phase decrease, as a result, the hair is mainly shorter, but it is recognized that the overall volume of hair is lost.

[0006] Another reason for feeling that the hair has become thinner is a change in the diameter or cross - sectional area of the hair, that is, individual hairs become thinner. The structure and size of human head hair or scalp hair vary depending on ethnic origin. Asian hair has a round and uniform shape, and the average diameter is 80 - 120 micrometers. Caucasian hair is oval, and 60 - 80 micrometers is considered the general average diameter of the hair. African hair has a flat oval shape, and 50 - 70 micrometers is considered the general average diameter. The average diameter also varies with age, increasing until the mid - 40s and then gradually decreasing.

[0007] Accordingly, an object of the present invention is to provide a care product suitable for reducing hair loss in combination with improving the hair structure, particularly including an increase in the diameter or cross-sectional area of the hair or an improvement in keratin expression. Furthermore, there is a need for a care product suitable for improving the structure of hair affected by the thinning of hair associated with aging. In particular, there is a need for such a product that can be administered locally.

Summary of the Invention

[0008] This object is achieved by (A) Sandal pentanol ((3-methyl-5-(2,2,3-trimethylcyclopent-3-en-1-yl)pentan-2-ol) and / or one or more sandal pentanol analogs, (B) Caffeine, (C) at least one C10-C18 fatty acid and / or their salts, (D) at least one surfactant, and (E) at least one cosmetically acceptable solvent comprising as components, (i) improving the hair structure, and (ii) reducing hair loss by the cosmetic use of a locally applicable rinse-off composition (RC).

[0009] According to a preferred embodiment, the subject of the present invention is the cosmetic use of a locally applicable rinse-off composition (RC) in combination with reducing hair loss (ii) for improving the hair structure, particularly the structure of mammalian hair such as human hair (i).

[0010] According to the present invention, surprisingly, it has been found that the combination of sandal pentanol, caffeine, and at least one C10-C18 fatty acid, and / or their salts is effective in improving the hair structure (i) and reducing hair loss (ii). The inventors have found that the combination of sandal pentanol, caffeine, and at least one C10-C18 fatty acid and / or their salts is suitable for reducing hair loss (ii) in combination with improving the hair structure (i), where the improvement of the hair structure preferably includes an increase in the cross-sectional area of the hair.

[0011] Furthermore, the inventors have found that the combination of sandal pentanol, caffeine, and at least one C10-C18 fatty acid and / or their salts is suitable for improving the hair structure, where the improvement of the hair structure (i) preferably includes an increase in the expression of keratin, particularly keratin 85, in combination with reducing hair loss (ii). Furthermore, the inventors have found that the combination of sandal pentanol, caffeine, and at least one C10-C18 fatty acid and / or their salts is suitable for improving the structure of hair affected by thinning of hair due to aging.

[0012] The cosmetic use of the locally applicable rinse-off composition (RC) of the present invention is suitable for improving the hair structure (i) in combination with reducing hair loss (ii). In one aspect, the cosmetic use of the locally applicable rinse-off composition (RC) of the present invention is suitable for improving the hair structure, where the improvement of the hair structure (i) includes an increase in the cross-sectional area of the hair in combination with reducing hair loss (ii). In another aspect, the cosmetic use of the locally applicable rinse-off composition (RC) of the present invention is suitable for improving the hair structure (i), where the improvement of the hair structure includes an increase in the expression of keratin, such as the expression of keratin 85, in combination with reducing hair loss (ii). In yet another aspect, the cosmetic use of the locally applicable rinse-off composition (RC) of the present invention is suitable for improving the structure of hair affected by thinning of hair due to aging in combination with reducing hair loss.

[0013] The cosmetic use of the locally applicable rinse-off composition (RC) of the present invention is further suitable for topical administration to the human scalp. The cosmetic use of the locally applicable rinse-off composition (RC) of the present invention is suitable for cosmetic and therapeutic uses in improving the hair structure (i) in combination with reducing hair loss (ii).

[0014] Definitions In the present specification, the terms "sandal pentanol" and "sandalwood" are used interchangeably. Sandal pentanol is a synthetic fragrance having a scent similar to sandalwood, and thus has been used as an inexpensive ingredient that mimics the scent of sandalwood in fragrances, skin softeners, and skin cleansers. Sandal pentanol, as well as structurally similar analogs such as the compound bulfanol, are alcohols having a completely different chemical structure from the components of natural sandalwood oil extracted by steam distillation from mature sandalwood trees, and are well-known as valuable components of fragrances. The IUPAC name of sandal pentanol is 3-methyl-5-(2,2,3-trimethylcyclopent-3-en-1-yl)pentan-2-ol.

[0015] As used in the present specification and the appended claims, the singular forms "a", "an", and "the" include plural referents unless the context clearly dictates otherwise. The term "may" in the context of the present specification means "permitted" or "able to", and is a synonym for the term "can". The term "may" as used in the present specification does not mean possibility or contingency.

[0016] The term "and / or" in the context of the present specification means either one or both. For example, an aqueous solution of A and / or B means an aqueous solution of only A, an aqueous solution of only B, and an aqueous solution of a combination of A and B.

[0017] The term "about" is understood to mean plus or minus 10 percent of the recited number, numerical value, or numerical range. According to an embodiment, the term "about" is understood to mean plus or minus 2 percent of the recited number, numerical value, or numerical range.

[0018] As used herein, the term "optionally" means that the corresponding step or feature may or may not be present. This includes both possibilities.

[0019] The terms "parts by weight" (PBW) and "parts by volume" (PBV) are used in their ordinary sense. When used in a mixed context, for example, when the amount of a component indicated by PBW is mixed with a component indicated by PBV, the terms PBW and PBV as used herein indicate the amount in grams of the component indicated by PBW relative to the volume in milliliters of the amount of the component indicated by PBV.

[0020] The term "composition" as used herein means a mixture or blend containing at least two components. A typical composition contains at least one functional component (e.g., an active ingredient such as sandalwood pentanol) and at least one solvent component (e.g., water or alcohol). The composition can exist in any suitable physical form, such as liquids, gels, foams, creams, etc., of various viscosities. The term "composition" can refer to a product that is ready for use, unless otherwise specified in the context.

[0021] "Ready-to-use scalp and hair treatment product" means a form in which the composition is actually applied to the human scalp or the skin area including the facial hair.

[0022] The term "substantially free of" a particular component means that, based on the total weight of the entity such as a composition, each component in the entity is less than 1.0% by weight. In particular, the term "substantially free of" means that each component in the entity is less than 0.5% by weight, such as less than 0.1% by weight, less than 0.01% by weight.

[0023] The term "free of" a particular component means an amount below the detection limit, assuming a detection possibility on a ppm (parts per million) basis (by weight). In particular, the term "free of" a particular component means that each component in the entity is less than 50 ppm by weight, such as less than 10 ppm by weight, such as less than 5 ppm by weight.

[0024] The term "consisting essentially of" means that, based on the total weight of the entity, there are no additional components not specifically described in the entity, such as a composition in an amount exceeding 1.0% by weight. In particular, the term "consisting essentially of" means that additional components not specifically described are not present in the entity in an amount exceeding 0.5% by weight, such as exceeding 0.1% by weight, such as exceeding 0.01% by weight. Needless to say, the additional components not specifically described are compatible with the specifically described components and do not interfere with their functions.

[0025] The term "consisting of" means that, assuming a detection possibility on a ppm (parts per million) basis (by weight), there are no additional components not specifically described in the entity, such as a composition, in an amount below the detection limit. In particular, the term "consisting of" means that additional components not specifically described are not present in the entity in an amount exceeding 50 ppm by weight, such as exceeding 10 ppm by weight, such as exceeding 10 ppm by weight. Needless to say, the additional components not specifically described are compatible with the specifically described components and do not interfere with their functions.

[0026] As used herein, the term "hair" generally means mammalian hair, but particularly refers to human hair. More specifically, for the purposes of the present invention, the term "hair" means human "scalp hair" or "head hair", and human "facial hair". The term "facial hair" includes beard, eyebrows, and eyelashes.

[0027] The term "improvement of hair structure" means the improvement of one or more structural phenomena of hair. For example, "improvement of hair structure" includes the improvement / increase of the "diameter" or "cross-sectional area" of hair "during growth". In another example, "improvement of hair structure" includes the improvement / increase of keratin expression, particularly the improvement / increase of the expression of KRT85. The term "keratin 85" or "KRT85" means human keratin 85.

[0028] The term "thinning of hair with aging" means the decrease in the volume of human hair caused by the decrease in the diameter or cross-sectional area of hair, and this decrease typically begins in the early to mid-40s and occurs depending on aging. Scientific research has demonstrated that the decrease in the diameter or cross-sectional area of hair due to aging is correlated with the decrease in keratin expression, including the decrease in the expression of KRT85.

[0029] The term "expression of KRT85" means the expression of human keratin 85. Immediately after the proliferative zone containing stem cells (often referred to as the "germ matrix" or zone A in many studies), KRT85 occurs as one of the first keratins to be expressed in cortical cells and forms short filaments (paired with KRT35 or KRT31) in the cytoplasm of the "pre-cortical hair matrix". KRT85 promotes lateral binding so that short intermediate filaments (IFs) bundle together. These first bundles are the first signs of the ultrastructure of keratin and are usually seen in the cortex at approximately the same height as the upper part of the dermal papilla. These intermediate filaments are always seen as tightly aligned bundles. When cortical cells move to zone B, the final fiber diameter and shape are determined when the Henle layer (inner root sheath) hardens. In zone C (the beginning of the keratinization region), the final shape and position are maintained. This suggests that the expression of KRT85 is directly correlated with the quality of the hair shaft, and an increase in the expression of KRT85 leads to an increase in the cross-sectional area of the hair.

DETAILED DESCRIPTION OF THE INVENTION

[0030] The inventors of the present invention have surprisingly found that a combination of sandal pentanol (component (A)), caffeine (component (B)), and at least one C10-C18 fatty acid and / or their salts (component (C)) is effective in improving the hair structure (i) and reducing hair loss (ii). The inventors of the present invention have surprisingly found that sandal pentanol (component (A)), caffeine (component (B)), and at least one C10-C18 fatty acid and / or their salts are synergistically effective in improving the hair structure (i) and reducing hair loss (ii).

[0031] Component (A) In the present case, the terms "(A)", "component (A)", and "sandal pentanol and / or one or more sandal pentanol analogs" are used synonymously and thus preferably have the same meaning.

[0032] Sandal pentanol is one of the active ingredients used according to the present invention for improving the hair structure (i) and reducing hair loss (ii). Sandal pentanol is a synthetic fragrance used as a component that mimics the scent of sandalwood. Sandal pentanol is an alcohol having a chemical structure completely different from that of the components of natural sandalwood oil, which is usually extracted from mature sandalwood trees by steam distillation.

[0033] The IUPAC name of sandal pentanol is 3-methyl-5-(2,2,3-trimethylcyclopent-3-en-1-yl)pentan-2-ol. Sandal pentanol has been shown to have a stimulating effect on the olfactory receptor OR2AT4 expressed in the human hair follicle epithelium.

[0034] Analogs or derivatives of sandal pentanol are each considered to have a similar effect on improving the hair structure (i) and reducing hair loss, and can be used in the present disclosure instead of or in addition to sandal pentanol. Suitable sandal pentanol analogs as active ingredients include the following: ·(4Z)-3-Methyl-5-(2,2,3-trimethylcyclopenta-3-en-1-yl)penta-4-en-2-ol (sandal pentenol) ·1-Methyl-2-((1,2,2-trimethylbicyclo(3.1.0)hex-3-yl)methyl)-cyclopropane-methanol (Sandal cyclopropane) ·(E)-3,3-Dimethyl-5-(2,2,3-trimethylcyclopenta-3-en-1-yl)penta-4-en-2-ol (santol pentenol) ·2-Methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)butanol (sandal cyclopentane) ·(E)-2-Ethyl-4-(2,2,3-trimethylcyclopenta-3-en-1-yl)but-2-en-1-ol (sandalrome) ·(E)-2-Methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol (sandal butenol)

[0035] According to an embodiment, the topically applicable rinse-off composition (RC) used according to the present invention may include one or more of the above sandal pentanol analogs in addition to the active ingredient, sandal pentanol. When present, the combination of sandal pentanol and one or more sandal pentanol analogs is present in the total amount as shown below in the case of sandal pentanol alone.

[0036] According to another embodiment, the topically applicable rinse-off composition (RC) used according to the present invention may include sandal pentanol as an active ingredient and may essentially not include or may not include the above sandal pentanol analogs.

[0037] Furthermore, according to a less preferred embodiment, the topically applicable rinse-off composition (RC) used in accordance with the present invention may contain one or more of the above sandal pentanol analogs instead of sandal pentanol as the active ingredient.

[0038] The amount of sandal pentanol in the topically applicable rinse-off composition (RC) used in accordance with the present invention is not particularly critical. Typically, sandal pentanol will be present in an amount of from 0.010 to 10.0 weight percent, based on the weight of the topically applicable rinse-off composition (RC). If the amount is less than 0.010 weight percent, it may be difficult to achieve the effects required in the present disclosure. At amounts exceeding 10.0 weight percent, rather than the effect being further enhanced, the cost of the material resources of the topically applicable rinse-off composition (RC) used in accordance with the present invention may increase. According to an embodiment, sandal pentanol may be present in an amount of from 0.050 to 5.0 weight percent, based on the weight of the topically applicable rinse-off composition (RC). According to a more specific embodiment, sandal pentanol may be present in an amount of from 0.10 to 2.0 weight percent, based on the weight of the topically applicable rinse-off composition (RC). According to an even more specific embodiment, sandal pentanol may be present in an amount of from 0.50 to 1.50 weight percent, based on the weight of the topically applicable rinse-off composition (RC).

[0039] When analogs of sandal pentanol are present, at least a portion of the sandal pentanol is replaced, or in addition to the sandal pentanol, the total amount of one or more of the sandal pentanol and the sandal pentanol analogs (see above) will be within the range indicated above for the case of sandal pentanol alone.

[0040] Component (B) In the present case, the terms “(B)”, “Component (B)”, and “caffeine” are used synonymously and thus preferably have the same meaning.

[0041] Caffeine is another active ingredient used according to the present invention for the improvement of hair structure (i) and the reduction of hair loss (ii). Caffeine is a plant alkaloid also known by the names theine, methyltheobromine, and galanin. The IUPAC name is 1,3,7-trimethylxanthine. Caffeine is a well-known stimulant present, for example, in coffee and black tea, but is also included in cocoa solids and products containing cocoa solids (especially dark chocolate), or kola nuts. Caffeine has a vasodilatory effect and thus increases the blood and nutrient supply to the hair follicles. According to research, caffeine has been found to promote the elongation of the hair shaft (enlarging the hair follicle), extend the duration of the anagen phase (lengthening the growth phase of the hair), and stimulate the proliferation of hair matrix keratinocytes (increasing keratin production).

[0042] The amount of caffeine in the topically applicable rinse-off composition (RC) used according to the present invention is not particularly critical. If present, caffeine will typically be present in an amount of 0.010 to 10.0 weight percent, based on the weight of the topically applicable rinse-off composition (RC). If the amount is less than 0.010 weight percent, it may be difficult to achieve the effects required by the present disclosure. At amounts exceeding 10.0 weight percent, rather than the effect being further enhanced, the cost of the material resources of the topically applicable rinse-off composition (RC) used according to the present invention may be increased.

[0043] According to an embodiment, caffeine may be present in an amount of 0.050 to 5.0 weight percent, based on the weight of the topically applicable rinse-off composition (RC). According to a more specific embodiment, caffeine may be present in an amount of 0.10 to 2.0 weight percent, based on the weight of the topically applicable rinse-off composition (RC). According to an even more specific embodiment, caffeine may be present in an amount of 0.50 to 1.5 weight percent, based on the weight of the topically applicable rinse-off composition (RC).

[0044] Component (C) In this case, the terms "(C)", "component (C)", and "at least one C10-C18 fatty acid and / or its salts" are used synonymously and thus preferably have the same meaning. "At least one C10-C18 fatty acid and / or its salts" also means exactly one C10-C18 fatty acid and / or its salts, and a mixture of two or more different C10-C18 fatty acids and / or their salts.

[0045] Another active ingredient used according to the present invention for improving the hair structure (i) and reducing hair loss (ii) is a C10-C18 fatty acid. The (one or more) fatty acids used for improving the hair structure (i) and reducing hair loss (ii) are one or more linear and / or branched, saturated and / or unsaturated C10-C18 fatty acids. Typically, one or more C10-C18 fatty acids will be linear fatty acids. According to an embodiment, the (one or more) C10-C18 fatty acids can be selected from capric acid (C10:0), lauric acid (C12:0), myristic acid (C14:0), isomyristic acid (C14:0), palmitic acid (C16:0), palmitoleic acid (C16:1), stearic acid (C18:0), oleic acid (C18:1), linoleic acid (C18:2), linolenic acid (C18:3), parinaric acid (C18:4), petroselinic acid (C18:1), or a combination thereof, and / or their salts.

[0046] According to an embodiment, the (one or more) C10-C18 fatty acids can include lauric acid (C12:0), myristic acid (C14:0), or a combination thereof. According to a particular embodiment, the (one or more) C10-C18 fatty acids can be selected from lauric acid (C12:0), myristic acid (C14:0), or a combination thereof. For example, the fatty acid component of the combination of active ingredients can be lauric acid (C12:0), and / or its salts.

[0047] According to an embodiment, the fatty acid component may include one or more unsaturated fatty acids. According to an embodiment, the (one or more) C10-C18 fatty acids may include palmitoleic acid (C16:1), oleic acid (C18:1), linoleic acid (C18:2), linolenic acid (C18:3), parinaric acid (C18:4), petroselinic acid (C18:1), or a combination thereof. For example, the fatty acid component may include linoleic acid (C18:2), and / or salts thereof.

[0048] According to a particular embodiment, the fatty acid component can be selected from palmitoleic acid (C16:1), oleic acid (C18:1), linoleic acid (C18:2), linolenic acid (C18:3), parinaric acid (C18:4), petroselinic acid (C18:1), or a combination thereof. For example, the fatty acid component can be selected from palmitoleic acid (C16:1), and / or linoleic acid (C18:2), and / or salts thereof.

[0049] When the fatty acid component includes one or more unsaturated fatty acids, each composition preferably includes an antioxidant in order to reduce the autoxidation of double bonds.

[0050] According to an embodiment, the topically applicable rinse-off composition (RC) used according to the present invention may essentially not contain or may not contain unsaturated C10-C18 fatty acids. According to a particular embodiment, the composition according to the present disclosure may essentially not contain or may not contain the unsaturated fatty acids themselves.

[0051] When present, the (one or more) C10-C18 fatty acids may be present in the form of a free acid or in the form of a cosmetically acceptable salt, such as an alkali metal salt, an alkaline earth metal salt, an ammonium salt, or a combination thereof. For example, when present, the (one or more) C10-C18 fatty acids may be present in the form of the (one or more) free acids.

[0052] The amount of the C10-C18 fatty acid(s) in the locally applicable rinse-off composition (RC) used according to the present invention is not particularly important. When present, the C10-C18 fatty acid(s) will typically be present in an amount of 0.010 to 10.0 weight percent, based on the weight of the locally applicable rinse-off composition (RC). If the amount is less than 0.010 weight percent, it may be difficult to achieve the effects required by the present disclosure. At amounts exceeding 10.0 weight percent, rather than the effects being further enhanced, the cost of the material resources of the locally applicable rinse-off composition (RC) used according to the present invention may increase.

[0053] When the amount of the C10-C18 fatty acid(s) is large, it is also necessary to increase the amount of the surfactant (component (D)), and the appearance or the feel of the hair may become greasy. According to an embodiment, the C10-C18 fatty acid(s) may be present in an amount of 0.050 to 3.0 weight percent, based on the weight of the locally applicable rinse-off composition (RC). According to a more specific embodiment, the C10-C18 fatty acid may be present in an amount of 0.05 to 1 weight percent, based on the weight of the locally applicable rinse-off composition (RC). According to an even more specific embodiment, the C10-C18 fatty acid may be present in an amount of 0.1 to 0.3 weight percent, based on the weight of the locally applicable rinse-off composition (RC) used.

[0054] Component (D) In this case, the terms "(D)", "component (D)", and "at least one surfactant" are used as synonyms and thus preferably have the same meaning. The term "at least one surfactant" means exactly one surfactant and a mixture of two or more different surfactants.

[0055] Suitable surfactants as component (D) include anionic, cationic, amphoteric, and nonionic surfactants.

[0056] The anionic surfactant can be selected from the group consisting of salts of the following compounds (e.g., alkali salts such as sodium salts, ammonium salts, amine salts, amino alcohol salts, and magnesium salts): alkyl sulfates, alkyl ether sulfates, alkyl amide ether sulfates, alkyl aryl polyether sulfates, monoglyceride sulfates; alkyl sulfonates, alkyl phosphates, alkyl amide sulfonates, alkyl aryl sulfonates, α-olefin sulfonates, paraffin sulfonates; alkyl sulfosuccinates, alkyl amide sulfosuccinates; alkyl sulfosuccinates; alkyl sulfacetates; alkyl ether phosphates; acyl sarcosinates; acyl isethionates; N-acyl taurates; and mixtures thereof. All alkyl or acyl radicals of these various compounds contain, for example, 8 to 24 carbon atoms, and the aryl radical is selected from, for example, a phenyl group and a benzyl group. Weak anionic surfactants such as alkyl-D-galacturonates and their salts, and polyoxyalkylenated (C6-C24) alkyl ether carboxylic acids, polyoxyalkylenated (C6-C24) alkyl aryl ether carboxylic acids, polyoxyalkylenated (C6-C24) alkyl amide ether carboxylic acids and their salts (e.g., those containing 2 to 50 ethylene oxide groups, etc.), and mixtures thereof can also be used. Anionic derivatives of polysaccharides, such as carboxyalkyl ethers of alkyl polyglucosides, can also be used.

[0057] Suitable (one or more) anionic surfactants (component (D)) can contain at least one anionic functional group selected from sulfates, sulfonates, phosphates, and carboxylates at its head. To avoid overlap with the combinations of the active ingredients of the present disclosure, the (one or more) anionic surfactants used in the compositions according to the present disclosure do not include fatty acids or their salts.

[0058] Suitable alkyl sulfates include ammonium lauryl sulfate, sodium lauryl sulfate (sodium dodecyl sulfate, SLS, or SDS), and alkyl ether sulfates such as sodium laureth sulfate (sodium lauryl ether sulfate or SLES), and sodium myreth sulfate. Further suitable anionic surfactants include doxate (dioctyl sodium sulfosuccinate), alkyl-aryl ether phosphate, alkyl ether phosphate, sodium lauroyl sarcosinate, ammonium laureth sulfate, disodium lauryl sulfosuccinate, and sodium lauryl sulfoacetate.

[0059] Preferred anionic surfactants can be selected from the group consisting of sodium lauryl ether sulfate, sodium laureth ether sulfate, sodium dodecyl sulfate, ammonium laureth ether sulfate, ammonium dodecyl sulfate, alkylbenzene sulfonate, and combinations thereof.

[0060] The surfactant can be a nonionic surfactant. The nonionic surfactant can be selected from the group consisting of lanolin alcohol, polyoxyethylene ethers of fatty alcohols, and mixtures thereof. The nonionic surfactant is preferably ceteth-n, where n is 2 to 100, or 10 to 30. Suitable nonionic surfactants are well-known compounds (for example, for this point, see "Handbook of Surfactants" by M. R. Porter, published by Blackie & Son (Glasgow and London), 1991, pp. 116-178). Preferred surfactants include nonionic surfactants, particularly those containing polyoxyethylated fatty alcohols or oils. Particularly preferred nonionic surfactants include polyoxyethylated castor oil and hydrogenated polyoxylated castor oil. Specific examples of nonionic surfactants that can be used in the compositions of the present disclosure are PEG-35 castor oil, PEG-40 hydrogenated castor oil, and combinations thereof.

[0061] Component (D) is preferably present in an amount of 5 to 30% by weight, more preferably 10 to 25% by weight, and particularly preferably 12 to 20% by weight, where the value of % by weight is based on the total weight of the locally applicable rinse-off composition (RC).

[0062] Component (E) In the present case, the terms “(E)”, “component (E)”, and “at least one cosmetically acceptable solvent” are used synonymously and thus preferably have the same meaning. The term “at least one cosmetically acceptable solvent” means exactly one cosmetically acceptable solvent and a mixture of two or more different cosmetically acceptable solvents.

[0063] The cosmetically acceptable solvent used in the locally applicable rinse-off composition (RC) is preferably water-based, alcohol-based, or water-alcohol-based. Typically, the cosmetically acceptable solvent comprises water and one or more monohydric and / or polyhydric C1-C4 alcohols. According to an embodiment, the solvent comprises water and an alcohol selected from ethanol, n-propanol, isopropanol, glycerol, ethylene glycol, propylene glycol, or a combination thereof.

[0064] Preferred as component (E) is water, glycerol, or a mixture of water and glycerol.

[0065] Component (E) is preferably present in an amount of 45 to 94.97% by weight based on the total weight of the locally applicable rinse-off composition (RC).

[0066] In a preferred embodiment, component (E) comprises at least 50% by weight, more preferably at least 70% by weight, and particularly preferably at least 80% by weight of water based on the total weight of component (E) contained in the locally applicable rinse-off composition (RC).

[0067] In another preferred embodiment, component (E) contains at least 50% by weight, more preferably at least 70% by weight, particularly preferably at least 80% by weight of glycerol, based on the total weight of component (E) contained in the locally applicable rinse-off composition (RC).

[0068] Optionally additional components The locally applicable rinse-off composition (RC) used according to the present invention can optionally contain additional components that enhance, supplement, or add to the benefits obtained by santal pentanol alone or in combination of active ingredients. Such additional optional components are hereinafter referred to as support components, oil components, and mineral components. Support components cover a wide range of substances that have diverse effects on physiological or metabolic processes. Oil components cover the range of natural essential oils and modified oils. Modified oils particularly include hydrogenated oils and oil components. Mineral components cover the range of minerals in water-soluble or alcohol-soluble forms.

[0069] According to an embodiment, the composition according to the present disclosure may further contain a support component. Examples of such support components include, in particular, vasodilators, blood circulation stimulants, antioxidants, vitamins, provitamins, etc. When present, the amount of the support component or a combination thereof will be in the range of 0.0010 to 5.0 weight percent, particularly 0.010 to 3.0 weight percent, based on the weight of the locally applicable rinse-off composition (RC).

[0070] The support component can include, for example, one or more of tocopherol, tocotrienol, tocopherol ester, nicotinic acid, nicotinamide, nicotin ester, vasodilatory plant extracts, camphor, royal jelly, biotin, vitamin B3, vitamin B12, vitamin C, vitamin D2, vitamin D3, vitamin E, vitamin K1, vitamin K2, panthenol (provitamin B5), omega-3 fatty acids, omega-6 fatty acids, folic acid, cannabidiol, amino acids, or a combination thereof.

[0071] According to an embodiment, the supporting component includes a vasodilator selected from tocopherols (alpha-, beta-, gamma-, or delta-tocopherol), particularly alpha-tocopherol, tocopherol esters (such as tocopherol acetate, tocopherol succinate, tocopherol nicotinate, including tocopherol succinate poly(oxyethylene)), nicotinic acid, nicotinamide, nicotinic ester, camphor; antioxidants such as vitamin C or polyphenols; testosterone-5α-reductase inhibitors such as arachidonic acid which is an omega-6 fatty acid; substances beneficial to hair health such as nicotinamide (niacinamide); or a combination thereof. According to an embodiment, the supporting component includes tocopherol or tocopherol acetate (vitamin E acetate), and / or niacinamide. Suitable vasodilatory plant extracts include roasted or distilled nettle extract (Urtica Diocia), roasted chestnut extract (Aesculus Hippocastanum), arnica extract (Arnica Montana), or hemp extract.

[0072] The oil component may include, for example, peppermint oil, rosemary essential oil, lavender essential oil, tea tree oil, ylang-ylang, thyme oil, cedarwood oil, clarifying essential oil, bergamot oil, jojoba oil, sunflower oil, hydrogenated ethylhexyl olivate, or a combination thereof. When present, the oil component will be present in the composition of the present disclosure in an amount of 0.0010 to 1.0 weight percent, particularly 0.010 to 0.50 weight percent, based on the weight of the locally applicable rinse-off composition (RC).

[0073] According to an embodiment, the oil component includes peppermint oil and / or hydrogenated ethylhexyl olivate.

[0074] The mineral component contains metal ions that have beneficial effects on the health of hair and / or scalp. The mineral component can include, for example, iron, zinc, or a combination thereof. When present, the mineral component will be present in the composition of the present disclosure at a molar concentration of 0.0050 to 0.50, for example 0.010 to 0.25.

[0075] The topically applicable rinse-off composition (RC) used according to the present invention can contain a support component, an oil component, or a mineral component alone or in any combination.

[0076] The topically applicable rinse-off composition (RC) used according to the present invention can optionally contain cosmetically acceptable additives that can contribute to the achievement or enhancement of the required properties or effects. According to an embodiment, the cosmetically acceptable additives can be selected from fragrances, emulsifiers, preservatives, pH adjusters, chelating agents, hair care materials or skin care materials, physiologically compatible silicone derivative compounds, light protectants, anti-peeling agents, hair gloss agents, combability improvers, degreasing agents, moisturizers, conditioning agents, viscosity adjusters, and cooling agents. The cosmetically acceptable additives can be used in any combination as needed.

[0077] Suitable cosmetically acceptable additives not specifically described below are described in the International Cosmetics Ingredient Dictionary and Handbook, (8th ed.; The Cosmetics, Toiletry, and Fragrance Association). In particular, Volume 2, Sections 3 (Chemical Classes) and 4 (Functions) are useful for identifying specific additives for achieving specific or multi-purpose objectives. Some of these additives are discussed below, but the disclosure is of course not exhaustive.

[0078] The appropriate amount ranges of fragrance, emulsifier, preservative, pH adjuster, chelating agent, hair care material or skin care material, physiologically compatible silicone derivative compound, sunscreen, anti-peeling agent, hair gloss enhancer, combability improver, degreaser, moisturizer, conditioning agent, viscosity modifier, and coolant are shown for the additives discussed below. These cosmetically acceptable additives can be present in a total amount of up to 20.0, particularly up to 15.0 weight percent, based on the weight of the topically applicable rinse-off composition (RC). Typically, the total amount of these cosmetically acceptable additives can be in the range of 0.010 to 10.0 weight percent, conveniently in the range of 0.010 to 7.0 weight percent, based on the weight of the topically applicable rinse-off composition (RC). For example, the total amount of these cosmetically acceptable additives can be in the range of 0.010 to 5.0 weight percent, conveniently in the range of 0.010 to 3.0 weight percent, based on the weight of the topically applicable rinse-off composition (RC).

[0079] The topically applicable rinse-off composition (RC) used according to the present invention may contain a fragrance or perfume. For example, the topically applicable rinse-off composition (RC) may contain 0.0010 to 1.50 weight percent, particularly 0.010 - 0.50 weight percent, of fragrance based on the weight of the topically applicable rinse-off composition (RC). The fragrance can provide an improved user experience by imparting a pleasant smell to the composition and / or evoking emotions such as a relaxing or exciting smell.

[0080] Alternatively, the topically applicable rinse-off composition (RC) used according to the present invention may be substantially free of fragrance and / or perfume. Some consumers prefer compositions that do not contain fragrance. The fragrance can be an animal-based fragrance or a plant-based fragrance. The animal-based fragrance can be selected from the group consisting of musk oil, civet, castoreum, ambergris, and mixtures thereof.

[0081] The plant-based fragrance can be selected from the group consisting of nutmeg extract, cardamom extract, ginger extract, cinnamon extract, patchouli oil, geranium oil, orange oil, mandarin oil, orange flower extract, cedarwood, vetiver, lavandin, ylang-ylang extract, tuberose extract, sandalwood oil, bergamot oil, rosemary oil, spearmint oil, peppermint oil, lemon oil, lavender oil, citronella oil, chamomile oil, clove oil, sage oil, neroli oil, labdanum oil, eucalyptus oil, verbena oil, mimosa extract, narcissus extract, carrot seed extract, jasmine extract, olibanum extract, rose extract, and mixtures thereof.

[0082] The perfumes are acetophenone, adoxal, aldehyde C-12, aldehyde C-14, aldehyde C-18, allyl caproate, ambroxan, amyl acetate, dimethyl indane derivative, α-amyl cinnamaldehyde, anethole, anisaldehyde, benzaldehyde, benzyl acetate, benzyl alcohol and ester derivative, benzyl propionate, benzyl salicylate, borneol, butyl acetate, camphor, carbitol, cinnamaldehyde, cinnamyl acetate, cinnamyl alcohol, cis-3-hexanol and ester derivative, cis-3-hexenyl methyl carbonate, citral, citronellol and ester derivative, cumin aldehyde, cyclamen aldehyde, cyclogalbanate, damascone, decalactone, decanol, estragole, dihydromyrcenol, dimethyl benzyl carbinol, 6,8-dimethyl-2-nonanol, dimethyl benzyl carbinyl butyrate, ethyl acetate, ethyl isobutyrate, ethyl butyrate, ethyl propionate, ethyl caprylate, ethyl cinnamate, ethyl hexanoate, ethyl valerate, ethyl vanillin, eugenol, exaltolide, fencon, fruity ester such as ethyl 2-methylbutyrate, galaxolide, geraniol and ester derivative, helional, 2-heptanone, hexenol, α-hexyl cinnamaldehyde, hydroxycitronellal, indole, isoamyl acetate, isoeugenol acetate, ionone, isoeugenol, isoamyl isovalerate, iso E super, limonene, linalool, lilial, linalyl acetate, liral, majantol, myol, melonal, menthol, p-methylacetophenone, methyl anthranilate, methyl cedrylone, methyl dihydrojasmonate, methyl eugenol, methyl ionone, methyl-α-naphthyl ketone, methyl phenyl vinyl carbinyl acetate, mugetanol, γ-nonalactone, octanal, phenylethyl acetate, phenyl-acetaldehyde dimethyl acetate, phenoxyethyl isobutyrate, phenylethyl alcohol, pinene, sandalol, santalol, stemone, thymol, terpene, triplal, triethyl citrate, 3,3,It may contain one or more scents selected from the group consisting of 5-trimethylcyclohexanol, γ-undecalactone, undecenal, vanillin, vertoone, verdox, and mixtures thereof.,

[0083] The topically applicable rinse-off composition (RC) used in accordance with the present disclosure may contain an opacifying agent, which may also be denoted by the term "clouding inducer". For example, the composition may contain from 0.10 to 5.0 weight percent, particularly from 0.50 to 2.0 weight percent, of an opacifying agent based on the weight of the topically applicable rinse-off composition (RC). Suitable opacifying agents include, for example, mineral pigments such as titanium dioxide, alumina, calcium carbonate. Other suitable opacifying agents include fatty alcohols and fatty acid esters, such as cetearyl alcohol, cetyl alcohol, ethylene glycol distearate, glyceryl stearate, glyceryl oleate, stearyl stearate, and the like.,

[0084] The topically applicable rinse-off composition (RC) used in accordance with the present disclosure may contain a preservative or a mixture of preservatives. The composition may contain the (one or more) preservatives in an amount of up to 1.0, for example from 0.0010 to 1.0, particularly from 0.010 to 0.50 weight percent based on the weight of the topically applicable rinse-off composition (RC). Cosmetically acceptable preservatives include organic acids such as para-hydroxybenzoic acid; organic acid salts such as sodium benzoate; compounds such as benzyl alcohol, phenoxyethanol, 1,3-bis(hydroxymethyl)-5,5-dimethylimidazolidine-2,4-dione; and mixtures thereof.,

[0085] The topically applicable rinse-off composition (RC) used in accordance with the present disclosure may contain a pH adjuster and / or a buffer in an amount sufficient to effectively adjust the pH of the composition. For example, the composition may contain up to 1.0, such as from 0.000010 to 1.0, particularly from 0.0010 to 0.50 weight percent of a pH adjuster, based on the weight of the topically applicable rinse-off composition (RC). Suitable pH adjusters and / or buffers for use in the present invention include ammonia, alkanolamines such as monoethanolamine, diethanolamine, triethanolamine, monopropanolamine, dipropanolamine, tripropanolamine, tripropanolamine, 2-amino-2-methyl-1-propanol, and 2-amino-2-hydroxymethyl-1,3,-propanediol and guanidinium salts, hydroxides and carbonates of alkali metals and ammonium such as sodium hydroxide, sodium silicate, sodium metasilicate, and ammonium carbonate, and acids such as organic and inorganic acids, for example, ascorbic acid, citric acid, acetic acid, or tartaric acid, phosphoric acid, hydrochloric acid, and mixtures thereof, but are not limited thereto.

[0086] Preferred alkaline pH adjusters include ammonia, ethanolamine, and alkali metal hydroxides, particularly sodium hydroxide. Preferred acidic pH adjusters include hydrochloric acid, ascorbic acid, or citric acid.

[0087] The locally applicable rinse-off composition (RC) used in accordance with the present invention may further comprise one or more chelating agents (also referred to as "chelators", "sequestering agents", or "sequestrants") in an amount sufficient to reduce the amount of metal available for interaction with the formulation components. Chelating agents are well known in the art, and a non-exhaustive list thereof is described in AE Martell & RM Smith, Critical Stability Constants, Vol. 1, Plenum Press, New York & London (1974) and AE Martell & RD Hancock, Metal Complexes in Aqueous Solution, Plenum Press, New York & London (1996). Typically, the composition may comprise one or more chelating agents in a total amount of from 0.0010 to 1.0 weight percent, particularly from 0.010 to 0.50 weight percent, based on the weight of the locally applicable rinse-off composition (RC).

[0088] The one or more chelating agents can be selected from the group consisting of carboxylic acids (such as aminocarboxylic acids), phosphonic acids (such as aminophosphonic acids), polyphosphoric acids (such as linear polyphosphoric acids), their salts, and mixtures thereof. "Their salts" in the context of chelating agents means all salts containing the same functional structure as the chelating agent, including alkali metal salts, alkaline earth metal salts, ammonium salts, substituted ammonium salts, and mixtures thereof; or sodium salts, potassium salts, calcium salts, magnesium salts, ammonium salts, and mixtures thereof; or monoethanolammonium salts, diethanolammonium salts, triethanolammonium salts, and mixtures thereof, including these.

[0089] One or more chelating agents can be one or more aminocarboxylic acid chelating agents containing one or more carboxylic acid moieties (-COOH) and one or more nitrogen atoms. The one or more aminocarboxylic acid chelating agents can be selected from the group consisting of diethylenetriaminepentaacetic acid (DTPA), ethylenediaminedisuccinic acid (EDDS), ethylenediamine-N,N'-diglutaric acid (EDDG), 2-hydroxypropylenediamine-N-N'-disuccinic acid (HPDDS), glycineamide-N,N'-disuccinic acid (GADS), ethylenediamine-N-N'-diglutaric acid (EDDG), 2-hydroxypropylenediamine-N-N'-disuccinic acid (HPDDS), ethylenediaminetetraacetic acid (EDTA), ethylenedicysteic acid (EDC), ethylenediamine-N-N'-bis(orthohydroxyphenylacetic acid) (EDDHA), diaminoalkyldi(sulfosuccinic acid) (DDS), N,N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid (HBED), their salts, and mixtures thereof. Conveniently, the chelating agent used in the composition according to the present disclosure can be, if any, EDTA.

[0090] The topically applicable rinse-off composition (RC) used according to the present disclosure can include a viscosity modifier called a "thickener" in the art. When present, such a viscosity modifier is typically used in the topically applicable rinse-off composition (RC) in an amount of 0.010 to 3.0 weight percent, particularly 0.50 to 1.0 weight percent, based on the weight of the topically applicable rinse-off composition (RC). Suitable cosmetically acceptable viscosity modifiers include nonionic polymers such as polysaccharides like cellulose, cellulose gum, or xanthan gum, and nonionic viscosity modifiers based on polyethers-1 such as the commercially available viscosity modifier Pure Thix1442.

[0091] The topically applicable rinse-off composition (RC) used in accordance with the present disclosure may further contain care materials such as plant or vegetable extracts, cationic polymers or cationic surfactants that provide hair care or skin care. Typical amounts of care materials in the compositions according to the present disclosure will be in the range of 0.010 to 5.0 weight percent, particularly 0.050 to 2.0 weight percent, based on the weight of the topically applicable rinse-off composition (RC).

[0092] Additional cosmetically acceptable additives that may be present in the topically applicable rinse-off composition (RC) used in accordance with the present invention include the following: · Physiologically compatible silicone derivative compounds, such as volatile or non-volatile silicones, or high molecular weight siloxane polymers, such as quaternium-80 (in an amount typically of 0.05 to 20 weight percent, particularly 0.10 to 5.0 weight percent, based on the weight of the composition) · Photoprotective agents, such as octyl methoxycinnamate, etc. · Anti-peeling agents (typically in an amount of about 0.01 to 2 weight percent) · Hair gloss agents, such as phenyltrimethicone, etc. · Combing improvers, such as cationic surfactants such as behentrimonium chloride, or cationic polymers such as polyquaternium-10 · Degreasing agents · Conditioning agents · Humectants, such as sodium lactate, sodium PCA, glycine, fructose, urea, niacinamide, inositol, etc. · Cooling agents, such as menthol, eucalyptol, geraniol, linalool, isopulegol, cubedol, p-menthane-3,8-diol, hydroxycitronellal, and their esters and derivatives; ketones such as mentone and carvone; carboxamides, or evaporative cooling agents, etc.

[0093] Cosmetically acceptable additives can be used in any combination, optionally or as necessary, in the topically applicable rinse-off composition (RC) used according to the present invention.

[0094] Substances that may be excluded The topically applicable rinse-off composition (RC) used according to the present invention may essentially not contain or may not contain a certain class of substances or compounds.

[0095] According to an embodiment, the topically applicable rinse-off composition (RC) used according to the present invention may essentially not contain biotin. According to an embodiment, the topically applicable rinse-off composition (RC) used according to the present invention may not contain biotin. According to a particular embodiment, the concentration of biotin can be less than 5 ppm by weight.

[0096] According to an embodiment, the topically applicable rinse-off composition (RC) used according to the present invention may essentially not contain quaternary ammonium compounds. According to an embodiment, the topically applicable rinse-off composition (RC) used according to the present invention may not contain quaternary ammonium compounds. According to a particular embodiment, the concentration of quaternary ammonium compounds can be less than 5 ppm by weight.

[0097] According to an embodiment, the topically applicable rinse-off composition (RC) used according to the present invention may essentially not contain silicone. According to an embodiment, the composition according to the present disclosure may not contain silicone. According to a particular embodiment, the concentration of silicone can be less than 5 ppm by weight.

[0098] According to an embodiment, the topically applicable rinse-off composition (RC) used in accordance with the present invention may essentially not contain a quaternary ammonium compound and a silicone. According to an embodiment, the topically applicable rinse-off composition (RC) used in accordance with the present invention may not contain a quaternary ammonium compound and a silicone. According to a particular embodiment, the concentration of the quaternary ammonium compound and the silicone may be less than 5 ppm by weight.

[0099] According to an embodiment, the polymer compound present in the topically applicable rinse-off composition (RC) exclusively used in accordance with the present invention is a film-forming polymer. In other words, according to an embodiment, the topically applicable rinse-off composition (RC) used in accordance with the present invention may essentially not contain a non-film-forming polymer. According to an embodiment, the topically applicable rinse-off composition (RC) used in accordance with the present invention may not contain a non-film-forming polymer. According to a particular embodiment, the concentration of the non-film-forming polymer may be less than 5 ppm by weight.

[0100] According to an embodiment, the topically applicable rinse-off composition (RC) used in accordance with the present invention may essentially not contain or may not contain a non-film-forming polymer selected from acrylate / steareth-20 methacrylate copolymer, carbomer, polyacrylamide, hydroxyethyl cellulose, xanthan gum, and polymers having similar chemical properties.

[0101] According to an embodiment, the topically applicable rinse-off composition (RC) used in accordance with the present invention may essentially not contain or may not contain an unsaturated fatty acid.

[0102] Topically applicable rinse-off composition (RC) Typically, sandal pentanol (Component (A)) will be present in an amount of from 0.010 to 10.0 weight percent, based on the weight of the topically applicable rinse-off composition (RC). Typically, caffeine (Component (B)) will be present in an amount of from 0.010 to 10.0 weight percent, based on the weight of the topically applicable rinse-off composition (RC). At least one C10-C18 fatty acid and / or their salts (Component (C)) will typically be present in an amount of from 0.010 to 2.0 weight percent, based on the weight of the topically applicable rinse-off composition (RC). For simplicity, based on the weight of the topically applicable rinse-off composition (RC) respectively, sandal pentanol (Component (A)) is present in an amount of from 0.10 to 5.0 weight percent, caffeine (Component (B)) is present in an amount of from 0.10 to 5.0 weight percent, and at least one C10-C18 fatty acid (Component (C)) will be present in an amount of from 0.050 to 3.0 weight percent.

[0103] According to an embodiment, based on the weight of the topically applicable rinse-off composition (RC) respectively, sandal pentanol (Component (A)) is present in an amount of from 0.50 to 2.0 weight percent, caffeine (Component (B)) is present in an amount of from 0.50 to 2.0 weight percent, and at least one C10-C18 fatty acid (Component (C)) will be present in an amount of from 0.10 to 2.0 weight percent. According to a more specific embodiment, based on the weight of the topically applicable rinse-off composition (RC) respectively, sandal pentanol (Component (A)) is present in an amount of from 0.80 to 1.50 weight percent, caffeine (Component (B)) is present in an amount of from 0.80 to 1.50 weight percent, and at least one C10-C18 fatty acid (Component (C)) will be present in an amount of from 0.10 to 1.0 weight percent.

[0104] According to embodiments comprising a combination of sandal pentanol (component (A)), caffeine (component (B)), and at least one C10-C18 fatty acid (component (C)), the weight ratio of sandal pentanol to caffeine can be from 1:2 to 2:1, more specifically from 1:1.5 to 1.5:1, particularly 1:1.2 to 1.2:1. In such embodiments, the weight ratio of sandal pentanol to at least one C10-C18 fatty acid can be from 10:1 to 1:1, more specifically from 8:1 to 1.5:1, particularly 5:1 to 2:1. Further, the weight ratio of caffeine to at least one C10-C18 fatty acid can similarly be from 10:1 to 1:1, more specifically from 8:1 to 1.5:1, particularly 5:1 to 2:1. Given that the molecular weights of sandal pentanol, caffeine, and C10-C18 fatty acids are fairly similar, the molar ratio will be similar to the weight ratio.

[0105] The topically applicable rinse-off composition (RC) used in the present disclosure can have a pH in the range of 3.0 to 8.0. According to embodiments, the pH can be within the range of 4.0 to 6.5, for example within the range of 4.5 to 6.0.

[0106] The topically applicable rinse-off composition (RC) used in the present invention is preferably at least one composition selected from the group consisting of hair lotions, hair conditioners, hair creams, hair shampoos, dry shampoos, hair foams, and shampoo bars.

[0107] In a preferred embodiment, the topically applicable rinse-off composition (RC) is a shampoo or a conditioner.

[0108] Non-therapeutic method Another aspect of the present invention is a non-therapeutic method for (i) improving hair structure and (ii) reducing hair loss, the following steps: a) rinsing the hair and scalp with water, b) Topically apply the rinse-off composition (RC) described herein to the hair and scalp for at least 1 minute, preferably for at least 2 minutes. c) Rinse the hair and scalp with water to remove the rinse-off composition (RC) described herein from the hair and scalp. comprising wherein steps a), b, and c) are performed at least once within a 48-hour period, preferably at least once within a 24-hour period. is a method.

[0109] The terms "topically applicable rinse-off composition (RC)" and "composition (RC)" are hereinafter used synonymously. The topically applicable rinse-off composition (RC) used according to the present invention can be used according to a method of applying the composition (RC) to at least a part of the scalp region or at least a part of the skin region including facial hair. Briefly, the composition (RC) can be applied to at least a part of the scalp region or at least a part of the skin region including facial hair and then or simultaneously gently massaged in.

[0110] Preferably, the composition (RC) is gently massaged in after rinsing the hair and scalp with water. The composition (RC) used according to the present invention is applied in an amount sufficient to obtain the desired effects (i and ii). In particular, to deliver a combination of effective amounts of active ingredients, namely sandal pentanol (component (A)), caffeine (component (B)), and at least one fatty acid and / or their salts (component (C)), the composition (RC) can be applied to at least a part of the scalp region or at least a part of the skin region including facial hair.

[0111] For example, to deliver a combination of effective amounts of active ingredients, namely sandal pentanol (component (A)), caffeine (component (B)) and at least one fatty acid and / or their salts (component (C)) daily, the composition (RC) used according to the present invention can be applied to at least a part of the scalp region or at least a part of the skin region including facial hair once, twice, or more than three times a day.

[0112] For example, a combination of active ingredients, namely, sandal pentanol (component (A)), caffeine (component (B)) and at least one fatty acid and / or their salts (component (C)), can be applied once or twice a day (24 hours) to at least a part of the scalp area or at least a part of the skin area including the facial hair.

[0113] When the composition (RC) is a shampoo, it has been found that applying the composition (RC) once a day (24 hours) is sufficient.

[0114] The composition (RC) used according to the present invention is preferably applied locally to at least a part of the scalp area or at least a part of the skin area including the facial hair for at least 1 minute, preferably at least 1.5 minutes, more preferably at least 2 minutes, in order to obtain the desired effects (i and ii).

[0115] In particular, the composition (RC) is preferably removed by applying water to the hair and scalp after use.

[0116] A further subject of the present disclosure is the use of the composition (RC) for the improvement of hair structure (i) and the reduction of hair loss (ii). For example, the present invention contemplates the use of the composition (RC) for the improvement of hair structure (i), where the improvement of hair structure includes an increase in the cross-sectional area of the hair. Furthermore, the present invention contemplates the use of the composition (RC) for the improvement of hair structure (i) and the reduction of hair loss (ii), where the improvement of hair structure includes an increase in the expression of keratin, particularly keratin 85. Furthermore, the present invention contemplates the use of the composition (RC) according to the present disclosure to improve the structure (i) of hair affected by the thinning of hair associated with aging.

[0117] The following examples illustrate the present invention in more detail, but the details of these examples should not be construed as limiting the scope of the claims.

[0118] Embodiment 1. The cosmetic use of a locally applicable rinse-off composition (RC) for (i) improving hair structure, and (ii) reducing hair loss comprising, for (A) sandalwood pentanol ((3-methyl-5-(2,2,3-trimethylcyclopent-3-en-1-yl)pentan-2-ol) and / or one or more sandalwood pentanol analogs, (B) caffeine, (C) at least one C10-C18 fatty acid and / or their salts, (D) at least one surfactant, and (E) at least one cosmetically acceptable solvent as components. Cosmetic use.

[0119] 2. The locally applicable rinse-off composition (RC) contains component (A) in an amount of 0.010 - 10 wt%, component (B) in an amount of 0.010 - 10 wt%, component (C) in an amount of 0.010 - 5 wt%, component (D) in an amount of 5.0 - 30 wt%, and component (E) in an amount of 45 - 94.97 wt% wherein the wt% values are based on the total weight of the locally applicable rinse-off composition (RC). Cosmetic use. Cosmetic use.

[0120] 3. The cosmetic use according to embodiment 1 or 2, wherein the improvement (i) in hair structure includes an increase in the cross-sectional area of the hair.

[0121] 4. The cosmetic use according to any one of embodiments 1 - 3, wherein the improvement (i) in hair structure includes an increase in the expression of keratin.

[0122] 5. The cosmetic use according to any one of embodiments 1 - 4, wherein the improvement (i) in hair structure includes an increase in the expression of keratin 85.

[0123] 6. The cosmetic use according to any one of Embodiments 1 to 5, wherein the reduction of hair loss (ii) is the reduction of androgenetic alopecia.

[0124] 7. The cosmetic use according to any one of Embodiments 1 to 6, wherein the weight ratio of component (A) to component (B) is in the range of 1:2 to 2:1, more specifically in the range of 1:1.5 to 1.5:1, and particularly in the range of 1:1.2 to 1.2:1.

[0125] 8. The cosmetic use according to any one of Embodiments 1 to 7, wherein component (D) is at least one surfactant for cleaning selected from the group consisting of anionic surfactants for cleaning, cationic surfactants for cleaning, and nonionic surfactants for cleaning, wherein fatty acid surfactants are excluded.

[0126] 9. The cosmetic use according to any one of Embodiments 1 to 8, wherein one or more sandal pentanol analogs that may be contained in component (A) are at least one sandal pentanol analog selected from the group consisting of sandal pentenol ((4Z)-3-methyl-5-(2,2,3-trimethylcyclopenta-3-en-1-yl)penta-4-en-2-ol), sandal cyclopropane (1-methyl-2-((1,2,2-trimethylbicyclo(3.1.0)hex-3-yl)methyl)-cyclopropane-methanol), santol pentenol ((E)-3,3-dimethyl-5-(2,2,3-trimethylcyclopenta-3-en-1-yl)penta-4-en-2-ol), sandal cyclopentane (2-methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)butanol), sandal lome ((E)-2-ethyl-4-(2,2,3-trimethylcyclopenta-3-en-1-yl)but-2-en-1-ol), and sandal butenol ((E)-2-methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol).

[0127] 10. Cosmetic use according to any one of Embodiments 1 to 9, comprising improving the structure of hair (i) that has been affected by thinning of hair associated with aging.

[0128] 11. Cosmetic use according to any one of Embodiments 1 to 10, wherein component (C) comprises at least 50% by weight of lauric acid and / or their salts based on the total amount of component (C) contained in a locally applicable rinse-off composition (RC).

[0129] 12. Cosmetic use according to any one of Embodiments 1 to 11, wherein component (A) comprises at least 50% by weight of sandal pentanol based on the total amount of component (A) contained in a locally applicable rinse-off composition (RC).

[0130] 13. Cosmetic use according to any one of Embodiments 1 to 12, wherein component (E) is at least one cosmetically acceptable solvent selected from the group consisting of water, ethanol, propanol, glycerol, ethylene glycol, and propylene glycol.

[0131] 14. Cosmetic use according to any one of Embodiments 1 to 13, wherein the locally applicable rinse-off composition (RC) is at least one composition selected from the group consisting of hair lotion, hair conditioner, hair cream, hair shampoo, dry shampoo, hair foam, and shampoo bar.

[0132] 15. A non-therapeutic method for (i) improving hair structure and (ii) reducing hair loss, a) rinsing the hair and scalp with water, b) locally applying the rinse-off composition (RC) according to any one of Embodiments 1 to 14 to the hair and scalp for at least 1 minute, preferably at least 2 minutes, c) rinsing the hair and scalp with water to remove the rinse-off composition (RC) according to any one of Embodiments 1 to 14 from the hair and scalp comprising, Steps a), b, and c) are carried out at least once within a period of 48 hours, preferably at least once within a period of 24 hours. Method.

Example

[0133] Research method In a single-center randomized clinical trial, the hair condition of the subjects was evaluated using Trichoscale®: Hair was cut using a clipper in a small area of about 2 cm. 2 The designated area located at the parietal-temporal region was shaved with a clipper, and a template was placed in that area to enable accurate shaving. When there is one subject, the area to be tested remains the same throughout the study period. Three days later, the hair was dyed, and a video image magnified 20 times was saved. This image was taken in an area of 0.903 cm 2 (measurement area). Trichoscale® measurement provides data on hair thickness; telogen rate; anagen rate; the number of anagen and telogen hairs, and anagen / telogen ratio.

[0134] The anagen rate was measured at the start (T0), as well as after 12 weeks (T3M), 24 weeks (T6M), 36 weeks (T9M), and 48 weeks (T12M).

[0135] The hair thickness was measured at the start (T0) and after 48 weeks (T12M).

[0136] Research subjects Regarding the anagen rate, the number of subjects included per leg was 33. All the subjects included had a telogen rate of over 20% at the start of the study. The number of subjects who completed the study after 48 weeks was 30, with 50% women and 50% men aged 35 to 65 years per leg.

[0137] Regarding hair thickness, the number of subjects included per leg was 30. All the subjects included had a telogen rate exceeding 20% at the start of the study. The number of subjects who completed the study after 48 weeks was 30, with 50% women and 50% men aged 35 to 65 years per leg.

[0138] Study setup The participants selected as study subjects used the product at home once a day for 48 weeks, massaging it into the hair and scalp for 2 minutes.

[0139] The formulation of the product used is shown below: TIFF2025081233000001.tif90170

[0140] Evaluation criteria At the above time point, experts performed Trichoscale (registered trademark) measurements. Both the anagen rate (percentage of hairs in the anagen phase) and hair thickness were analyzed.

[0141] The anagen phase is the active growth phase of the hair follicle. During the anagen phase, the cells of the hair root divide rapidly and the hair shaft increases. An increase in the anagen rate suggests a reduction in hair loss as the number of hairs in the anagen phase increases.

[0142] Results The comparison of hair thickness and anagen rate before and after is statistically significant at all time points compared to the initial ("T0") anagen rate.

[0143] The hair thickness also increases, and the measured average after 48 weeks (T12M) of using the product is statistically significantly higher compared to the initial ("T0") hair thickness: TIFF2025081233000002.tif50170TIFF2025081233000003.tif38170

Claims

1. A cosmetic use of a topically applicable rinse-off composition (RC), comprising: (i) improving hair structure, and (ii) reduction in hair loss for, (A) sandalpentanol ((3-methyl-5-(2,2,3-trimethylcyclopent-3-en-1-yl)pentan-2-ol) and / or one or more sandalpentanol analogues; (B) caffeine, (C) at least one C10 to C18 fatty acid and / or salt thereof; (D) at least one surfactant, and (E) at least one cosmetically acceptable solvent Contains as an ingredient Cosmetic use.

2. A topically applicable rinse-off composition (RC) comprising: Component (A) in an amount of 0.010 to 10% by weight, Component (B) in an amount of 0.010 to 10% by weight, Component (C) in an amount of 0.010 to 5% by weight, Component (D) in an amount of 5.0 to 30% by weight, and Component (E) in an amount of 45 to 94.97% by weight Including, The weight percent values ​​are based on the total weight of the topically applicable rinse-off composition (RC).

2. The cosmetic use according to claim 1.

3. 3. The cosmetic use according to claim 1 or 2, wherein the improvement of hair structure (i) comprises an increase in the cross-sectional area of ​​the hair.

4. 4. The cosmetic use according to any one of claims 1 to 3, wherein the improvement of hair structure (i) comprises an increase in the expression of keratin.

5. 5. The cosmetic use according to any one of claims 1 to 4, wherein the improvement of hair structure (i) comprises an increase in the expression of keratin 85.

6. 6. The cosmetic use according to any one of claims 1 to 5, wherein the reduction in hair loss (ii) is a reduction in androgenetic alopecia.

7. 7. The cosmetic use according to any one of claims 1 to 6, wherein the weight ratio of component (A) to component (B) is in the range of 1:2 to 2:1, more particularly in the range of 1:1.5 to 1.5:1, in particular in the range of 1:1.2 to 1.2:

1.

8. 8. The cosmetic use according to any one of claims 1 to 7, wherein component (D) is at least one cleansing surfactant selected from the group consisting of anionic cleansing surfactants, cationic cleansing surfactants, and non-ionic cleansing surfactants, excluding fatty acid surfactants.

9. The one or more sandalpentanol analogs that may be included in component (A) are sandalpentenol ((4Z)-3-methyl-5-(2,2,3-trimethylcyclopent-3-en-1-yl)pent-4-en-2-ol), sandalcyclopropane (1-methyl-2-((1,2.2-trimethylbicyclo(3.1.0)hex-3-yl)methyl)-cyclopropane-methanol), santholpentenol ((E)-3,3-dimethyl-5-(2,2,3-trimethylcyclopent-3-en-1-yl)pent-4-en-2-ol), 9. The cosmetic use according to any one of claims 1 to 8, wherein the at least one analogue of sandalpentanol is selected from the group consisting of sandalcyclopentane (2-methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)butanol), sandalrom ((E)-2-ethyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)but-2-en-1-ol), and sandalbutenol ((E)-2-methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol).

10. 10. The cosmetic use according to any one of claims 1 to 9, wherein improving hair structure (i) comprises improving the structure of hair affected by age-related thinning of hair.

11. 11. The cosmetic use according to any one of claims 1 to 10, wherein component (C) comprises at least 50% by weight of lauric acid and / or salts thereof, based on the total amount of component (C) contained in the topically applicable rinse-off composition (RC).

12. A cosmetic use according to any one of claims 1 to 11, wherein component (A) comprises at least 50% by weight of sandalpentanol, based on the total amount of component (A) contained in the topically applicable rinse-off composition (RC).

13. 13. The cosmetic use according to any one of claims 1 to 12, wherein component (E) is at least one cosmetically acceptable solvent selected from the group consisting of water, ethanol, propanol, glycerol, ethylene glycol, and propylene glycol.

14. 14. The cosmetic use according to any one of claims 1 to 13, wherein the topically applicable rinse-off composition (RC) is at least one composition selected from the group consisting of a hair lotion, a hair conditioner, a hair cream, a hair shampoo, a dry shampoo, a hair foam, and a shampoo bar.

15. (i) improving hair structure and (ii) reducing hair loss, comprising the steps of: a) rinsing the hair and scalp with water; b) topically applying a rinse-off composition (RC) according to any one of claims 1 to 14 to the hair and scalp for at least 1 minute, preferably at least 2 minutes, c) rinsing the hair and scalp with water to remove the rinse-off composition (RC) according to any one of claims 1 to 14 from the hair and scalp. Including, A method wherein steps a), b) and c) are carried out at least once within a 48 hour period, preferably at least once within a 24 hour period.

Images