Oral composition

Abstract

To provide an oral composition that can allow enjoyment of the function of digestible oligosaccharide and suppresses the decomposition of the digestible oligosaccharide by digestive enzyme and suppresses absorption into the gastrointestinal tract.SOLUTION: Provided is a powdered beverage that is characterized by containing maltotriose, barley young leaf and inulin.SELECTED DRAWING: Figure 1

Description

Technical Field

[0001] The present invention relates to an oral composition containing a digestible oligosaccharide and a predetermined material.

Background Art

[0002] Since digestible oligosaccharides have various functions, they may be blended in food and drink products in small amounts. For example, glucosyl sucrose is used as a low-cariogenic sweetener because it does not produce insoluble glucan that causes tooth decay. (See Patent Document 1).

[0003] On the other hand, digestible oligosaccharides are decomposed by digestive enzymes and absorbed as sugars in the stomach and small intestine, so they are not preferable from the viewpoints of diet and beauty.

Prior Art Documents

Patent Documents

[0004]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0005] An object of the present invention is to provide an oral composition that can enjoy the functions of a digestible oligosaccharide and suppress the decomposition of such a digestible oligosaccharide by digestive enzymes to suppress absorption into the gastrointestinal tract.

Means for Solving the Problems

[0006] The present inventors have found that by blending two or more selected from vitamins, barley, lactic acid bacteria, and water-soluble dietary fiber together with a digestible oligosaccharide, the decomposition of the digestible oligosaccharide by digestive enzymes is suppressed, and the present invention has been completed. In particular, it has been found that even when a vitamin is blended alone, the decomposition of a digestible oligosaccharide by digestive enzymes is extremely effectively suppressed.

[0007] That is, the present invention is as follows. [1] An oral composition characterized by containing digestible oligosaccharides and two or more materials selected from vitamins, barley, lactic acid bacteria, and water-soluble dietary fiber. [2] An oral composition characterized by containing digestible oligosaccharides and vitamins.

Effect of the Invention

[0008] The oral composition of the present invention can enjoy the functions of digestible oligosaccharides and can suppress the absorption of digestible oligosaccharides into the gastrointestinal tract.

Brief Description of the Drawings

[0009]

Figure 1

Embodiments for Carrying Out the Invention

[0010] The oral composition according to the first invention contains digestible oligosaccharides and two or more materials (hereinafter sometimes referred to as the materials of the present invention) selected from vitamins, barley, lactic acid bacteria, and water-soluble dietary fiber. It is preferable to contain three or more kinds of the materials of the present invention, and it is more preferable to contain all of them. In particular, it is preferable to contain vitamins and / or barley.

[0011] The oral composition according to the second invention contains digestible oligosaccharides and vitamins. As other components, it is preferable to contain at least one of barley, lactic acid bacteria, and water-soluble dietary fiber, and it is more preferable to contain two or more kinds.

[0012] The oral composition of the present invention can enjoy the functions of digestible oligosaccharides and can suppress the absorption of such digestible oligosaccharides. That is, the oral composition of the present invention can suppress the absorption of sugars that are not preferable from the viewpoint of dieting, etc., while making use of functions such as the appropriate sweetness of digestible oligosaccharides, suppression of deterioration of the composition (improvement of shelf life), and masking of unpleasant odors. Therefore, the oral composition of the present invention is particularly useful for diet foods and the like.

[0013] Hereinafter, each material contained in the oral composition of the present invention will be described. [Digestible oligosaccharides] The digestible oligosaccharides in the present invention are oligosaccharides of three sugars or more that are decomposed by human digestive enzymes and absorbed in the stomach and small intestine to become energy. The number of constituent sugars of the digestible oligosaccharides that can be used in the present invention is preferably three sugars or more and ten sugars or less, more preferably three sugars or more and eight sugars or less, still more preferably three sugars or more and six sugars or less, and particularly preferably three sugars or more and four sugars or less from the viewpoint of effects. Examples of digestible oligosaccharides include malt oligosaccharides, isomalto oligosaccharides, soy oligosaccharides, glucosyl sucrose, etc. Malt oligosaccharides are preferred from the viewpoint of being able to enjoy the effects of the present invention more. Specific examples of malt oligosaccharides include maltotriose, maltotetraose, maltopentaose, maltohexaose, etc. Maltotriose is particularly preferred from the viewpoint of being able to enjoy the effects of the present invention more. These digestible oligosaccharides can be used alone or in combination of two or more.

[0014] The content of digestible oligosaccharides is not particularly limited, but is preferably 0.0001% by mass or more, more preferably 0.001% by mass or more, still more preferably 0.01% by mass or more, and particularly preferably 0.05% by mass or more in terms of dry mass with respect to the entire oral composition. The upper limit is not particularly limited, but is preferably 30% by mass, more preferably 10% by mass, still more preferably 5% by mass, and particularly preferably 1% by mass.

[0015] [Materials of the present invention] (Vitamin) As vitamins, various vitamins can be used, which may be water-soluble vitamins or fat-soluble vitamins. However, from the viewpoint of better enjoying the effects of the present invention, water-soluble vitamins are preferred. Examples of water-soluble vitamins include vitamin B group (vitamin B3, B5, B6, B9, B12, B13, B15, B17, etc.) and vitamin C. Among water-soluble vitamins, from the viewpoint of better enjoying the effects of the present invention, the vitamin B group is preferred, and vitamin B6 (pyridoxine) is particularly preferred. Among vitamin B6, pyridoxine hydrochloride is particularly preferred. Examples of fat-soluble vitamins include vitamin A, D, E, K, etc. These vitamins can be used alone or in combination of two or more.

[0016] The content of vitamins is not particularly limited. However, from the viewpoint of better enjoying the effects of the present invention, based on the dry mass, it is preferably 0.00001% by mass or more, more preferably 0.001% by mass or more, still more preferably 0.01% by mass or more, and particularly preferably 0.03% by mass or more with respect to the whole oral composition. The upper limit is not particularly limited, but is preferably 30% by mass, more preferably 10% by mass, still more preferably 5% by mass, and particularly preferably 3% by mass.

[0017] The blending mass ratio of digestible oligosaccharides and vitamins is not particularly limited. However, from the viewpoint of better enjoying the effects of the present invention, in terms of dry mass conversion, it is preferably 1:0.001 to 1:100, more preferably 1:0.01 to 1:10, still more preferably 1:0.05 to 1:5, and particularly preferably 1:0.1 to 1:1.

[0018] (Barley) Barley (Hordeum vulgare L.) is native to Central Asia and is an annual or biennial herb belonging to the Poaceae family. It is broadly classified into two-row barley, six-row barley, etc. according to the ear shape. Any barley such as two-row barley or six-row barley may be used as the barley used in the present invention. Also, any variety may be used. As the part used in the present invention, leaves are preferred from the viewpoint of being able to better enjoy the effects of the present invention, green leaves are preferred among the leaves, and young leaves are particularly preferred. Also, the stem may be included together with the leaves.

[0019] For barley, processed products obtained by processing barley can be used. For example, ground products, squeezed juices, extracts, etc. can be used. Examples of the ground products include dry powders, shredded pieces and their dried products (dried shredded pieces), granules, etc. The squeezed juice or extract may be in a liquid state, but can also be used as a paste or dry powder (squeezed juice powder, extract powder). The extract can be obtained by extraction using an appropriate solvent. As the solvent, for example, water (warm water, hot water), ethanol, aqueous ethanol can be used. In the present invention, from the viewpoint of being able to better enjoy the effects of the present invention, it is particularly preferred to use dry powder of young barley leaves (young barley leaf powder).

[0020] The content of barley is not particularly limited, but from the viewpoint of being able to better enjoy the effects of the present invention, based on the dry mass, 1% by mass or more is preferred, 5% by mass or more is more preferred, 10% by mass or more is further preferred, and 30% by mass or more is particularly preferred with respect to the entire oral composition. The upper limit is not particularly limited, but 90% by mass is preferred, 80% by mass is more preferred, 60% by mass is further preferred, and 50% by mass is particularly preferred.

[0021] The compounding mass ratio of the digestible oligosaccharide and barley is not particularly limited, but from the viewpoint of being able to better enjoy the effects of the present invention, in terms of dry mass conversion, it is preferably 1:0.1 to 1:10000, more preferably 1:1 to 1:1000, further preferably 1:10 to 1:300, and particularly preferably 1:50 to 1:200.

[0022] Lactic acid bacteria The lactic acid bacteria in the present invention mean the general term for bacteria that produce lactic acid by metabolism, and is a concept including Bifidobacterium. Examples of lactic acid bacteria include Bifidobacterium bifidum, Bifidobacterium breve, Bifidobacterium infantis, Bifidobacterium lactis, Bifidobacterium longum, Bifidobacterium adolescentis, Bifidobacterium mongoliense, Lactbacillus brevis, Lactobacillus gasseri, Lactobacillus acidophilus, Lactobacillus buchneri, Lactobacillus bulgaricus, Lactobacillus delburvecki, Lactobacillus casei, Lactobacillus crispatus, Lactobacillus curvatus, Lactobacillus halivaticus, Lactobacillus pentosus, Lactobacillus plantarum, Lactobacilus paracasei, Lactobacillus rhamnosus, Lactobacillus salivarius, Lactobacillus sporogenes, Lactobacillus sakei, Lactobacillus fructivorans, Lactobacillus hilgardii, Lactobacillus reuteri, Lactobacillus fermentum, Enterococcus faecalis (sometimes referred to as Streptococcus faecalis), Enterococcus faesium (sometimes referred to as Streptococcus faesium), Streptococcus thermophilus, Lactococcus lactis (sometimes referred to as Streptococcus lactis), Leuconostoc mesenteroides, Leuconostoc oenos, Pediococcus acidilactici, PediococcusExamples include *Leuconostoc pentosaceus*, *Staphylococcus carnosus*, *Staphylococcus xylosus*, *Tetragenococcus halophilus*, *Bacillus coagulans*, *Bacillus mesentericus*, etc. *Bifidobacterium bifidum*, *Bifidobacterium breve*, *Bifidobacterium longum*, *Lactobacillus gasseri*, *Lactobacillus acidophilus*, *Lactobacillus casei*, *Lactobacillus plantarum*, *Lactobacillus paracasei*, *Lactobacillus fermentum*, *Enterococcus faecalis* (formerly *Streptococcus faecalis*), *Enterococcus faecium* (formerly *Streptococcus faecium*), *Streptococcus thermophilus*, *Lactococcus lactis* (formerly *Streptococcus lactis*), *Bacillus coagulans*, *Bacillus mesentericus* are preferred. In addition, lactic acid bacteria other than bifidobacteria can also be used. These lactic acid bacteria can be used alone or in combination of two or more. Depending on the dosage form and quality of the oral composition of the present invention, those having properties such as heat resistance, acid resistance, sugar resistance, salt resistance, spore formation, etc. can be appropriately selected. The method for obtaining lactic acid bacteria is not particularly limited, and for example, lactic acid bacteria isolated from foods such as yogurt and vegetables or commercially available products can be used. From the viewpoint of being able to enjoy the effects of the present invention more, it is particularly preferable to use lactic acid bacteria belonging to the genus *Lactobacillus*.

[0023] The content of lactic acid bacteria is not particularly limited, but from the viewpoint of more enjoying the effects of the present invention, based on the dry mass, it is preferably 0.00001% by mass or more, more preferably 0.001% by mass or more, still more preferably 0.005% by mass or more, and particularly preferably 0.01% by mass or more with respect to the whole oral composition. The upper limit is not particularly limited, but preferably 5% by mass, more preferably 1% by mass, still more preferably 0.5% by mass, and particularly preferably 0.1% by mass.

[0024] The blending mass ratio of the digestible oligosaccharide and lactic acid bacteria is not particularly limited, but from the viewpoint of more enjoying the effects of the present invention, in terms of dry mass conversion, it is preferably 1:0.001 to 1:300, more preferably 1:0.01 to 1:100, still more preferably 1:0.01 to 1:10, and particularly preferably 1:0.03 to 1:3.

[0025] (Water-soluble dietary fiber) Water-soluble dietary fiber refers to water-soluble components among indigestible components (dietary fiber) in foods that are not digested by human digestive enzymes contained in foods. The water-soluble dietary fiber in the present invention is not particularly limited, and examples thereof include indigestible dextrin, pectin, guar gum enzyme degradation product, guar gum, agarose, glucomannan, polydextrose, alginic acid and its salts, β-glucan, inulin, carrageenan, fucoidan, and derivatives thereof. These can be used alone or in combination of two or more.

[0026] In the present invention, inulin is preferred among these from the viewpoint of more enjoying the effects of the present invention. Inulin is a polysaccharide contained in plants such as agave, garlic, Chinese chives, chicory, artichoke, and Jerusalem artichoke, and these plants or those extracted from these plants can be used. Among these, inulin derived from agave is particularly preferred. In addition, inulin can also be synthesized from sucrose by a fermentation method, and such synthetic products may be used.

[0027] The content of the water-soluble dietary fiber is not particularly limited. However, from the viewpoint of better enjoying the effects of the present invention, based on the dry mass, it is preferably 0.01% by mass or more, more preferably 0.1% by mass or more, still more preferably 1% by mass or more, and particularly preferably 5% by mass or more with respect to the whole oral composition. The upper limit is not particularly limited, but preferably 90% by mass, more preferably 50% by mass, still more preferably 30% by mass, and particularly preferably 20% by mass.

[0028] The blending mass ratio of the digestible oligosaccharide and the water-soluble dietary fiber is not particularly limited. However, from the viewpoint of better enjoying the effects of the present invention, in terms of dry mass conversion, it is preferably 1:0.1 to 1:1000, more preferably 1:3 to 1:500, still more preferably 1:5 to 1:100, and particularly preferably 1:10 to 1:60.

[0029] The oral composition of the present invention can be used as so-called health foods such as functional foods whose efficacy display has been approved by a prescribed institution such as specific health foods, nutrient function foods, and foods with function claims, in addition to general foods, food additives, feeds, etc., and also as pharmaceuticals (including quasi-drugs).

[0030] Although the oral composition of the present invention contains a digestible oligosaccharide, based on the α-glucosidase inhibitory action of the material of the present invention, the absorption of such a digestible oligosaccharide into the gastrointestinal tract is suppressed, so it is useful as a diet food or the like.

[0031] That is, the oral composition of the present invention can be used as an oral composition for diet (anti-obesity) such as so-called health foods and pharmaceuticals. Such an oral composition for diet contains digestible oligosaccharides and the material of the present invention, and is not particularly limited as long as it can be distinguished from other products as a product in terms of being used for diet. For example, any of the main body, packaging, instruction manual, and promotional materials of the product according to the present invention that displays the fact that it has a diet function is included in the scope of the present invention. Note that the oral composition for diet of the present invention is not limited to those in which the material of the present invention is displayed as an active ingredient for diet on the packaging of the product or the like. For example, it may not specify the active ingredient, or it may display a specific material as the active ingredient.

[0032] Specific examples of the oral composition for diet of the present invention include so-called health foods that display "For those who are concerned about their weight", "Boost metabolism", "Help reduce body fat in those who are overweight", "Enhance the ability to metabolize fat", "Support style", "For those who are concerned about body fat", "For those who are overweight", "For those who are concerned about their weight (BMI)", "Reduce weight and abdominal fat (visceral fat and subcutaneous fat)", "Reduce waist circumference", "Lose weight", "Towards an ideal body", "Diet", "Slim", "Towards a healthy daily life", "Support health", etc.

[0033] In addition, since the oral composition of the present invention has an α-glucosidase inhibitory effect, an effect of suppressing sugar digestion and absorption, an effect of suppressing blood glucose level rise, and an effect of preventing diabetes and diabetes complications can be expected. Therefore, the oral composition of the present invention can also be used as a composition for inhibiting α-glucosidase, a composition for suppressing sugar digestion and absorption, a composition for suppressing blood glucose level rise, and a composition for preventing diabetes and diabetes complications.

[0034] Examples of the form of the oral composition of the present invention include, for example, tablet form, capsule form, powder form, granule form, liquid form, granular form, rod form, plate form, block form, solid form, round form, paste form, cream form, caplet form, gel form, chewable form, stick form, etc. Among these, in terms of being able to better enjoy the effects of the present invention, tablet form, capsule form, powder form, granule form, and liquid form are preferred. Specifically, supplements, container-packed beverages filled in PET bottles, cans, bottles, etc., instant beverages (powdered beverages) to be dissolved in water (hot water), milk, fruit juice, green juice, etc. for drinking, and food additives can be exemplified. These are preferred in that they can be easily drunk during meals, etc., and can enhance palatability. Also, when the present invention is a powdered beverage, since the oral composition of the present invention has the characteristic of being easily dispersed in water, it is particularly preferred that it is a powdered beverage.

[0035] The oral composition of the present invention can be produced by adding other components other than the components of the present invention, if necessary, and by known methods. Examples of other components other than the components of the present invention include, for example, minerals such as calcium, magnesium, phosphorus, iron; sulfur-containing compounds contained in taurine, garlic, etc.; flavonoids or flavonoid-like substances such as hesperidin, quercetin; proteins such as collagen; peptides; amino acids; animal fats; vegetable fats; pulverized or extracted products of animals and plants, etc.

Examples

[0036] Hereinafter, the present invention will be described based on examples. [Example 1] (Test substance) As the vitamin, vitamin B6 (pyridoxine hydrochloride) was used. As the barley, barley young leaf powder produced by the method described in Patent No. 3277181 was used. Specifically, the harvested barley young leaves were subjected to blanching treatment with hot water, then dried until the moisture content was 5% by weight or less, coarsely pulverized, and then further heated at 110 °C or higher and finely pulverized to produce the barley young leaf powder. As the lactic acid bacterium, Lactobacillus gasseri prepared at 50 mg / mL was used, which was incubated at 70 °C for 30 min. As the water-soluble dietary fiber, agave inulin extracted from the stem of agave, dried, and powdered was used.

[0037] [Test for Inhibiting Absorption of Digestible Oligosaccharides] Using maltotriose as the digestible oligosaccharide, a test for inhibiting the absorption of digestible oligosaccharides was conducted. Specifically, it was tested how much the decomposition of maltotriose by α-glucosidase was inhibited. Details are as follows.

[0038] (1) Weighed each test substance into a 1.5 mL tube, added 56 mM maleic acid buffer (solvent) to make it 50 mg / mL, and vortexed for 60 min. (2) After centrifugation with a centrifuge (10,000 rpm, room temperature, 5 min), the supernatant was collected to obtain the test substance solution. (3) Each test substance solution was mixed at the ratios shown in Table 1 below to prepare a sample solution.

[0039] [Table 1]

[0040] (4) Added 15 μL of each sample to a new 1.5 mL tube. The solvent was used for the control. (5) Added 15 μL of the crude enzyme solution to the test tube and 15 μL of the crude enzyme solution inactivated by heating at 98 °C for 2 min to the blank tube, vortexed gently, and flushed, then pre-incubated at 37 °C for 5 min.

[0041] (6) After adding 90 μL of the substrate solution to the test and blank tubes, vortexed and incubated at 37 °C for 30 min. (7) Heated each tube at 98 °C for 2 min and cooled on ice to obtain the reaction solution. (8)40 μL of each reaction solution was added to a 96-well plate, and 300 μL of the color-developing agent attached to the commercially available kit "Glucose CII Test Wako" was added. After incubation at 37 °C for 5 min, the absorbance at 505 nm was measured using a plate reader. (9)Using the measured absorbance, the inhibition rate was calculated using the following formula.

[0042] Inhibition rate (%) =(1 - [(Sample test - Sample blank ) / (Control test - Control blank )]) × 100

[0043] Note that 1.56 mM maltotriose was used as the substrate solution. As the enzyme solution, 100 mg of rat intestinal acetone powder and 900 μL of 56 mM maleic acid buffer were suspended, homogenized on ice for 2 min, centrifuged at 3,000 rpm, 4 °C for 10 min, and the supernatant diluted 4-fold with 56 mM maleic acid buffer was used.

[0044] The results (inhibition rate %) are shown in Figure 1.

[0045] As shown in Figure 1, the composition of Example 1 containing vitamins showed extremely high α-glucosidase inhibitory activity. In addition, for the compositions of Examples 2 to 5 containing two or more kinds of the materials of the present invention, a synergistic improvement in the α-glucosidase inhibition rate was observed compared to the case where one kind of the material of the present invention was used.

[0046] [Formulation Example] According to the following formulation, the oral composition of the present invention was produced.

[0047] The raw materials were mixed to obtain the amounts shown in Table 2 below to obtain a powdered beverage (Formulation Example 1). The powdered beverage was sub-packaged so that each pack was 3 g and designed to be suspended in 100 mL of water for drinking. The obtained powdered beverage has the effects of the present invention and is a powdered beverage with good dispersibility and excellent taste.

[0048]

Table 2

[0049] After mixing each component shown in Table 3 below, tablets with a weight of 250 mg per tablet and a tablet diameter of 8 mm were produced using a tableting machine (Formulation Example 2). The obtained tablets have the effects of the present invention and are further tablets with good lubricity and easy to swallow.

[0050]

Table 3

[0051] The mixture shown in Table 4 below was encapsulated in hard capsules to produce a capsule preparation (300 mg) (Formulation Example 3). Five of the obtained hard capsules are taken per day. The obtained hard capsules have the effects of the present invention.

[0052]

Table 4

[0053] After mixing the components described in Table 5 below, the mixture was sterilized at 90°C for 10 minutes to produce a beverage (Formulation Example 4). The obtained liquid preparation has the effects of the present invention and is further excellent in flavor and taste and is a beverage with a good throat feel.

[0054]

Table 5

Industrial Applicability

[0055] Since the oral composition of the present invention can be used as so-called health foods and the like, it is industrially useful.

Claims

[Claim 1] A powdered beverage comprising maltotriose, young barley leaves, inulin and vitamin B6.

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