Inhalation irritation reducer, composition for controlling harmful microorganisms, and aerosol product for controlling harmful microorganisms

Abstract

To provide an inhalation irritation reducer having superior ability to reduce irritation resulting from inhalation of sprayed particles from an aerosol product for controlling harmful microorganisms.SOLUTION: The present invention provides an inhalation irritation reducer for reducing irritation derived from control components during use of an aerosol product for controlling harmful microorganisms, wherein the reducer comprises, as an active ingredient, at least one selected from the group consisting of: fatty acid esters; aromatic carboxylic acid esters; dibasic acid esters; saturated acyclic alcohols having 3 to 22 carbon atoms; hydrocarbon solvents; glycol solvents; and water-soluble polymers.SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to an inhalation irritation reducing agent for reducing irritation derived from a control component during the use of an aerosol product for controlling harmful microorganisms, a composition for controlling harmful microorganisms, and an aerosol product for controlling harmful microorganisms using the composition for controlling harmful microorganisms.

Background Art

[0002] Conventionally, aerosol products for controlling harmful microorganisms such as molds, bacteria, and viruses have been used.

[0003] In this type of aerosol product, when the ejected fine particles are inhaled through the nostrils, the nasal mucosa may be irritated, and an irritating odor caused by such fine particles may occur. In addition, the components contained in the fine particles may also generate an irritating odor.

[0004] In order to remove such an irritating odor caused by inhalation, it has been proposed to add glycerin acetate to an aerosol (aerosol product) (see, for example, Patent Document 1).

Prior Art Documents

Patent Documents

[0005]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0006] However, the glycerin acetate of Patent Document 1 targets irritations of pesticides, cosmetics, pharmaceuticals, etc., and cannot reduce the irritation caused by inhalation of the ejected particles of the aerosol product for controlling harmful microorganisms.

[0007] The present invention has been made in view of the above circumstances, and an inhalation irritation reducing agent excellent in reducing irritation caused by inhalation of injection particles of an aerosol product for controlling harmful microorganisms, a composition for controlling harmful microorganisms, and an aerosol product for controlling harmful microorganisms using the composition for controlling harmful microorganisms are provided.

Means for Solving the Problems

[0008] The inhalation irritation reducing agent according to the present invention for solving the above problems is an inhalation irritation reducing agent that reduces irritation derived from a control component during use of an aerosol product for controlling harmful microorganisms, and is characterized in that at least one selected from the group consisting of fatty acid esters, aromatic carboxylic acid esters, dibasic acid esters, saturated acyclic alcohols having 3 to 22 carbon atoms, hydrocarbon solvents, glycol solvents, and water-soluble polymers is used as an active ingredient.

[0009] According to the inhalation irritation reducing agent having this configuration, by using at least one selected from the group consisting of fatty acid esters, aromatic carboxylic acid esters, dibasic acid esters, saturated acyclic alcohols having 3 to 22 carbon atoms, hydrocarbon solvents, glycol solvents, and water-soluble polymers as an active ingredient, it is possible to reduce irritation derived from a control component during use of an aerosol product for controlling harmful microorganisms.

[0010] In the inhalation irritation reducing agent according to the present invention, it is preferable that the control component contains at least one selected from the group consisting of a cationic control component, a glycerin monofatty acid ester-based control component, a phenol-based control component, a quaternary ammonium salt, and an azole-based control component.

[0011] According to the inhalation irritation reducing agent of this configuration, since the aerosol product for controlling harmful microorganisms contains at least one selected from the group consisting of a cationic control component, a glycerin monofatty acid ester control component, a phenolic control component, a quaternary ammonium salt, and an azole control component as a control component, among the control components, the irritation caused by the cationic control component, the glycerin monofatty acid ester control component, the phenolic control component, the quaternary ammonium salt, and the azole control component can be reduced. Therefore, by selecting these control components, the effect of the inhalation irritation reducing agent can be more easily felt.

[0012] In the inhalation irritation reducing agent according to the present invention, The fatty acid ester preferably contains at least one selected from the group consisting of isopropyl myristate, 2-ethylhexyl palmitate, isopropyl palmitate, ethyl hexanoate, allyl heptanoate, and butyl stearate.

[0013] According to the inhalation irritation reducing agent of this configuration, since the fatty acid ester contains at least one selected from the above group, the irritation derived from the control component when using the aerosol product for controlling harmful microorganisms can be further reduced.

[0014] In the inhalation irritation reducing agent according to the present invention, The usage amount relative to 1 part by mass of the control component is preferably 0.1 to 2000 parts by mass.

[0015] According to the inhalation irritation reducing agent of this configuration, by setting the usage amount of the inhalation irritation reducing agent within the above range, the irritation derived from the control component when using the aerosol product for controlling harmful microorganisms can be further reduced.

[0016] In the inhalation irritation reducing agent according to the present invention, The aerosol product for controlling harmful microorganisms is preferably a metered-dose aerosol product.

[0017] According to the inhalation stimulus reducing agent of this configuration, since the aerosol product for controlling harmful microorganisms is a metered spray aerosol product, an appropriate amount of aerosol can be sprayed by setting the number of sprays according to the volume of the treatment space. Therefore, excessive use of the control component and the inhalation stimulus reducing agent can be suppressed, and the stimulus derived from the control component can be efficiently reduced.

[0018] Another composition for controlling harmful microorganisms according to the present invention for solving the above problems is a control component, at least one selected from the group consisting of fatty acid esters, aromatic carboxylic acid esters, dibasic acid esters, saturated acyclic alcohols having 3 to 22 carbon atoms, hydrocarbon solvents, glycol solvents, and water-soluble polymers and contains.

[0019] According to the composition for controlling harmful microorganisms of this configuration, by containing a control component and at least one selected from the group consisting of fatty acid esters, aromatic carboxylic acid esters, dibasic acid esters, saturated acyclic alcohols having 3 to 22 carbon atoms, hydrocarbon solvents, glycol solvents, and water-soluble polymers, the stimulus derived from the control component during the use of the aerosol product for controlling harmful microorganisms using the composition for controlling harmful microorganisms can be reduced.

[0020] In the composition for controlling harmful microorganisms according to the present invention, it is preferable that the control component contains at least one selected from the group consisting of cationic control components, glycerin monofatty acid ester-based control components, phenol-based control components, quaternary ammonium salts, and azole-based control components.

[0021] According to the composition for controlling harmful microorganisms of this configuration, by containing at least one selected from the group consisting of a cationic control component, a glycerin mono-fatty acid ester control component, a phenolic control component, a quaternary ammonium salt, and an azole control component as a control component, it is possible to reduce the irritation caused by the cationic control component, the glycerin mono-fatty acid ester control component, the phenolic control component, the quaternary ammonium salt, and the azole control component. Therefore, by selecting these control components, the effect of reducing the inhalation irritation of the aerosol product for controlling harmful microorganisms using the composition for controlling harmful microorganisms becomes easier to feel.

[0022] In the composition for controlling harmful microorganisms according to the present invention, It is preferable that the fatty acid ester contains at least one selected from the group consisting of isopropyl myristate, 2-ethylhexyl palmitate, isopropyl palmitate, ethyl hexanoate, allyl heptanoate, and butyl stearate.

[0023] According to the composition for controlling harmful microorganisms of this configuration, by containing at least one fatty acid ester selected from the above group, it is possible to further reduce the irritation derived from the control component during the use of the aerosol product for controlling harmful microorganisms using the composition for controlling harmful microorganisms.

[0024] In the composition for controlling harmful microorganisms according to the present invention, The content of at least one selected from the group consisting of the fatty acid ester, aromatic carboxylic acid ester, dibasic acid ester, saturated acyclic alcohol having 3 to 22 carbon atoms, hydrocarbon solvent, glycol solvent, and water-soluble polymer with respect to 1 part by mass of the control component is preferably 0.1 to 2000 parts by mass.

[0025] According to the composition for controlling harmful microorganisms of this configuration, by setting the content of at least one selected from the group consisting of fatty acid esters, aromatic carboxylic acid esters, dibasic acid esters, saturated acyclic alcohols having 3 to 22 carbon atoms, hydrocarbon solvents, glycol solvents, and water-soluble polymers within the above range, it is possible to further reduce the irritation derived from the control component during the use of the aerosol product for controlling harmful microorganisms using the composition for controlling harmful microorganisms.

[0026] In the composition for controlling harmful microorganisms according to the present invention, The kinematic viscosity at 20°C is preferably adjusted to be 4 to 8 mm 2 / s.

[0027] According to the composition for controlling harmful microorganisms of this configuration, by adjusting the kinematic viscosity at 20°C to be within the above range, it appropriately acts on the particle size of the spray particles when the composition for controlling harmful microorganisms is sprayed, and it is possible to further reduce the irritation derived from the control component during the use of the aerosol product for controlling harmful microorganisms using the composition for controlling harmful microorganisms.

[0028] In the composition for controlling harmful microorganisms according to the present invention, It is preferably one that reduces inhalation irritation.

[0029] Another aerosol product for controlling harmful microorganisms according to the present invention for solving the above problems is A pressure-resistant container, An aerosol composition filled in the pressure-resistant container, and has The aerosol composition contains a stock solution for controlling harmful microorganisms and a propellant, The stock solution for controlling harmful microorganisms is the above composition for controlling harmful microorganisms.

[0030] According to the aerosol product for controlling harmful microorganisms of this configuration, since the aerosol composition filled in the pressure-resistant container contains the above-mentioned composition for controlling harmful microorganisms as the undiluted solution for controlling harmful microorganisms, it is possible to reduce the irritation derived from the control component when using the aerosol product for controlling harmful microorganisms.

[0031] In the aerosol product for controlling harmful microorganisms according to the present invention, It is preferably a metered-dose aerosol product.

[0032] According to the aerosol product for controlling harmful microorganisms of this configuration, since it is a metered-dose aerosol product, an appropriate amount of the undiluted solution for controlling harmful microorganisms can be sprayed as an aerosol by setting the number of sprays according to the volume of the treatment space. Therefore, excessive use of the undiluted solution for controlling harmful microorganisms (composition for controlling harmful microorganisms) can be suppressed, and the irritation derived from the control component can be efficiently reduced.

[0033] In the aerosol product for controlling harmful microorganisms according to the present invention, It is preferably one with reduced inhalation irritation.

Mode for Carrying Out the Invention

[0034] Hereinafter, the inhalation irritation reducing agent, the composition for controlling harmful microorganisms, and the aerosol product for controlling harmful microorganisms of the present invention will be described. However, the present invention is not intended to be limited to the configurations described in the embodiments described below.

[0035] [Inhalation Irritation Reducing Agent] The inhalation irritation reducing agent of the present invention is an inhalation irritation reducing agent that reduces irritation (hereinafter, may be referred to as "inhalation irritation") derived from a control component when using an aerosol product for controlling harmful microorganisms, and comprises at least one selected from the group consisting of fatty acid esters, aromatic carboxylic acid esters, dibasic acid esters, saturated acyclic alcohols having 3 to 22 carbon atoms, hydrocarbon solvents, glycol solvents, and water-soluble polymers as an active ingredient. The inhalation irritation reducing agent is a liquid composition for controlling harmful microorganisms dissolved or dispersed in a solvent (organic solvent or water) together with a control component for controlling harmful microorganisms, and the composition for controlling harmful microorganisms is used as a stock solution for controlling harmful microorganisms (hereinafter, may be referred to as "aerosol stock solution"), and can be used as an aerosol product for controlling harmful microorganisms obtained by filling the aerosol stock solution and a propellant into a pressure container. Incidentally, the inhalation irritation reducing agent itself can also be used as a solvent for the composition for controlling harmful microorganisms.

[0036] <Harmful microorganisms> "Harmful microorganisms" means organisms or substances derived from organisms such as bacteria, molds, viruses, mites, and pollen. That is, in this specification, in addition to microorganisms such as bacteria and molds, fine substances such as viruses, mites, and pollen are also collectively referred to as "harmful microorganisms".

[0037] <Fatty acid ester> A fatty acid ester is an esterified product of a fatty acid and an alcohol. The fatty acid ester is preferably a compound represented by the following formula (1). When the fatty acid ester is a diester, it also corresponds to the dibasic acid ester described later. That is, such a diester corresponds to both a fatty acid ester and a dibasic acid ester and serves as both. R1-COO-R2 ··· (1) In formula (1), R1 is a monovalent chain hydrocarbon group having 3 to 17 carbon atoms, and R2 is a monovalent chain hydrocarbon group having 1 to 27 carbon atoms. The ratio (R1 / R2) of R1 to R2 is preferably 0.3 to 17. The above-mentioned chain hydrocarbon group may be a straight-chain hydrocarbon group or a hydrocarbon group having a branched chain, and may be a saturated hydrocarbon group or an unsaturated hydrocarbon group. The total number of carbon atoms of the fatty acid ester is preferably 8 to 45, more preferably 8 to 30. By setting R1, R2, the ratio (R1 / R2), and the total number of carbon atoms within the above ranges, the inhalation irritation during the use of the aerosol product for controlling harmful microorganisms can be further reduced.

[0038] Examples of such fatty acid esters include lauryl methacrylate, hexyl butyrate, ethyl hexanoate, butyl hexanoate, allyl heptanoate, cetyl 2-ethylhexanoate (cetyl octanoate), isoamyl decanoate (isopentyl decanoate), butyl decanoate, isopropyl laurate, butyl laurate, methyl laurate, isopropyl myristate (IPM), butyl myristate, octyldodecyl myristate, myristyl myristate (tetradecyl myristate), 2-ethylhexyl palmitate (octyl palmitate, IOP), isopropyl palmitate, cholesteryl isostearate, isobutyl oleate, octyl oleate, methyl oleate, stearyl stearate, butyl stearate, 2-ethylhexyl stearate (2-ethylhexyl octadecanoate), isotridecyl stearate (octadecanoic acid, isotridecyl ester), methyl stearate and other higher fatty acid esters having 8 to 30 carbon atoms. Among the above fatty acid esters, isopropyl myristate (IPM), 2-ethylhexyl palmitate (IOP), isopropyl palmitate, ethyl hexanoate, allyl heptanoate, and butyl stearate are preferred. By selecting isopropyl myristate (IPM), 2-ethylhexyl palmitate (IOP), isopropyl palmitate, ethyl hexanoate, allyl heptanoate, and butyl stearate as the fatty acid ester, the inhalation irritation during the use of the aerosol product for controlling harmful microorganisms can be further reduced. The fatty acid ester can be used alone or as a mixture of two or more kinds.

[0039] <Aromatic carboxylic acid ester> An aromatic carboxylic acid ester is an esterification product of an aromatic carboxylic acid and an alcohol. As the aromatic carboxylic acid ester, a compound represented by the following formula (2) is preferred. R3-COO-R4 ··· (2) In formula (2), R3 is a monovalent aromatic hydrocarbon group having 6 to 10 carbon atoms, which may be substituted or unsubstituted, and R4 is a monovalent aromatic hydrocarbon group having 6 to 10 carbon atoms. The total number of carbon atoms of the aromatic carboxylic acid ester is preferably 13 to 21. The above-mentioned aromatic hydrocarbon group may have only an aromatic ring structure, or may have an aromatic ring structure and a chain hydrocarbon group (a structure in which at least one hydrogen atom of the aromatic ring structure is substituted with a linear hydrocarbon group or a hydrocarbon group having a branched chain). Examples of the above-mentioned substituent include a hydroxyl group (-OH). By setting R3, R4, and the total number of carbon atoms within the above ranges, the inhalation irritation during the use of the aerosol product for controlling harmful microorganisms can be further reduced.

[0040] Examples of such aromatic carboxylic acid esters include benzyl salicylate, methyl salicylate, hexyl salicylate, benzyl benzoate, etc. Among these, benzyl salicylate is preferred as the aromatic carboxylic acid ester. By selecting benzyl salicylate as the aromatic carboxylic acid ester, the inhalation irritation during the use of the aerosol product for controlling harmful microorganisms can be further reduced. The aromatic carboxylic acid ester can be used alone as one kind, or can also be used as a mixture of two or more kinds.

[0041] <Dibasic acid ester> The dibasic acid ester is an esterification product of a dibasic acid and an alcohol. The dibasic acid ester is preferably a compound represented by the following formula (3). R5-OOC-R6-COO-R7 ··· (3) In formula (3), R5 is a monovalent chain hydrocarbon group having 6 to 10 carbon atoms, R6 is a divalent chain hydrocarbon group having 6 to 10 carbon atoms, and R7 is a monovalent chain hydrocarbon group having 6 to 10 carbon atoms. The total number of carbon atoms of the dibasic acid ester is preferably 20 to 30. The above-mentioned chain hydrocarbon group may be a linear hydrocarbon group or a hydrocarbon group having a branched chain, and may be a saturated hydrocarbon group or an unsaturated hydrocarbon group. By setting R5, R6, R7, and the total number of carbon atoms within the above ranges, the inhalation irritation during the use of the aerosol product for controlling harmful microorganisms can be further reduced.

[0042] Examples of such dibasic acid esters include di(2-ethylhexyl) sebacate, diethyl phthalate, dibutyl phthalate, dibutyl succinate, and the like. Among these, di(2-ethylhexyl) sebacate is preferred as the dibasic acid ester. By selecting di(2-ethylhexyl) sebacate as the dibasic acid ester, inhalation irritation during the use of the aerosol product for controlling harmful microorganisms can be further reduced. The dibasic acid ester can be used alone as one kind, or can also be used as a mixture of two or more kinds.

[0043] <Saturated acyclic alcohols having 3 to 22 carbon atoms> Saturated acyclic alcohols having 3 to 22 carbon atoms are, specifically, saturated aliphatic acyclic alcohols, which may be either straight-chain or branched-chain. The number of carbon atoms in the saturated acyclic alcohol is preferably 3 to 18, more preferably 4 to 15, and most preferably 5 to 13. Examples of saturated acyclic alcohols having 3 to 22 carbon atoms include n-propanol, n-butanol, 1-pentanol, 1-hexanol, 1-heptanol, 1-octanol, 2-ethylhexanol, 1-nonanol, 1-decanol, 1-undecanol, 1-lauryl alcohol, 1-tridecanol, 2-hexadecanol, behenyl alcohol, pentanediol, hexanediol, heptanediol, octanediol, nonanediol, decanediol, dodecanediol, etc. Among these saturated acyclic alcohols, 1-pentanol, 1-hexanol, 1-heptanol, 1-octanol, 2-ethylhexanol, 1-nonanol, 1-decanol, 1-undecanol, 1-lauryl alcohol, 1-tridecanol are preferred. By selecting 1-pentanol, 1-hexanol, 1-heptanol, 1-octanol, 2-ethylhexanol, 1-nonanol, 1-decanol, 1-undecanol, 1-lauryl alcohol, 1-tridecanol as the saturated acyclic alcohol, the inhalation irritation during the use of the aerosol product for controlling harmful microorganisms can be further reduced. Saturated acyclic alcohols having 3 to 22 carbon atoms can be used alone or as a mixture of two or more.

[0044] <Hydrocarbon solvent> Examples of hydrocarbon solvents include normal paraffin, isoparaffin, etc. Among these, normal paraffin is preferred as the hydrocarbon solvent. By selecting normal paraffin as the hydrocarbon solvent, the inhalation irritation during the use of the aerosol product for controlling harmful microorganisms can be further reduced. Hydrocarbon solvents can be used alone or as a mixture of two or more.

[0045] <Glycol solvent> Examples of glycol solvents include glycol solvents having 3 to 10 carbon atoms. Specifically, propylene glycol, 1,3-butylene glycol, pentylene glycol, hexylene glycol, dipropylene glycol, glycerin, etc. may be mentioned. Among these, as the glycol solvent, propylene glycol and glycerin are preferred. By selecting propylene glycol and glycerin as the glycol solvent, the inhalation irritation during the use of the aerosol product for controlling harmful microorganisms can be further reduced. The glycol solvent can be used alone or as a mixture of two or more kinds.

[0046] <Water-soluble polymer> As the water-soluble polymer, various natural products, synthetic products or semi-synthetic products can be used. For example, various gums such as heteropolysaccharides such as guar gum, locust bean gum, quince seed gum, tara gum, tragacanth gum, karaya gum, xanthan gum, welan gum, rhamsan gum, carrageenan, gum arabic, etc., alginic acid derivatives such as sodium alginate, ammonium alginate, propylene glycol alginate ester, vinyl-based water-soluble polymer compounds such as polyvinyl alcohol, polyvinyl pyrrolidone, polyvinyl methacrylate, synthetic organic water-soluble polymer compounds such as polyethylene oxide, polyacrylic acid, sodium polyacrylate, polyacrylamide, etc., natural water-soluble polymer compounds such as dextrin, pectin, gelatin, casein, glue, albumin, etc., cellulose derivatives such as methyl cellulose, carboxymethyl cellulose, carboxyethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, starch derivatives such as sodium carboxymethyl starch, hydroxyethyl starch, etc. can be exemplified. Among these, polyvinyl pyrrolidone which is a vinyl-based water-soluble polymer compound is preferable. The water-soluble polymer is preferably used in a state dissolved in a solvent (for example, ethanol, etc.). The water-soluble polymer acts as a thickener in the composition for controlling harmful microorganisms described later and can increase its viscosity. It is considered that the water-soluble polymer can reduce the inhalation irritation derived from the control component due to such an improvement in viscosity. Further, when the composition for controlling harmful microorganisms is applied to an aerosol product as described later, if the viscosity of the composition for controlling harmful microorganisms becomes too high, there is a risk of poor spraying. Therefore, in this case, it is preferable to appropriately set the blending amount of the water-soluble polymer in consideration of the balance between inhalation reduction and poor spraying. The water-soluble polymer can be used alone or as a mixture of two or more kinds.

[0047] <Usage amount of inhalation irritation reducing agent for control component> The amount (addition amount) of the inhalation irritation reducing agent relative to 1 part by mass of the controlling ingredient is preferably from 0.1 to 2000 parts by mass, more preferably from 0.2 to 2000 parts by mass, and even more preferably from 4 to 56 parts by mass. That is, the mass ratio (a / b) of the controlling ingredient (a) to the inhalation irritation reducing agent (b) is preferably from 1 / 2000 to 1 / 0.1, more preferably from 1 / 2000 to 1 / 0.2, and even more preferably from 1 / 56 to 1 / 4. By setting the addition amount of the inhalation irritation reducing agent within the above range, the inhalation irritation during the use of the aerosol product for controlling harmful microorganisms can be further reduced.

[0048] <Application form of the inhalation irritation reducing agent> The inhalation irritation reducing agent of the present embodiment can be used as one component of the composition for controlling harmful microorganisms together with the controlling ingredient, and can be used as an aerosol product for controlling harmful microorganisms using the composition for controlling harmful microorganisms. For example, a liquid composition for controlling harmful microorganisms in which the controlling ingredient and the inhalation irritation reducing agent are dissolved or dispersed in a solvent (organic solvent) is used as an aerosol stock solution, and the aerosol stock solution and a propellant are filled into a pressure container to obtain an aerosol product for controlling harmful microorganisms. The aerosol product for controlling harmful microorganisms to which the inhalation irritation reducing agent is applied is preferably a metered spray type aerosol product. Since the aerosol product for controlling harmful microorganisms is a metered spray type aerosol product, an appropriate amount of aerosol can be sprayed by setting the number of sprays according to the volume of the treatment space. Therefore, excessive use of the controlling ingredient and the inhalation irritation reducing agent can be suppressed, and the irritation derived from the controlling ingredient can be efficiently reduced.

[0049] [Composition for controlling harmful microorganisms] The composition for controlling harmful microorganisms of the present embodiment contains a controlling ingredient and at least one selected from the group consisting of a fatty acid ester, an aromatic carboxylic acid ester, a dibasic acid ester, a saturated acyclic alcohol having 3 to 22 carbon atoms, a hydrocarbon solvent, a glycol solvent, and a water-soluble polymer.

[0050] According to the harmful microorganism control composition, by containing a control component and at least one selected from the group consisting of a fatty acid ester, an aromatic carboxylic acid ester, a dibasic acid ester, a saturated acyclic alcohol having 3 to 22 carbon atoms, a hydrocarbon solvent, a glycol solvent, and a water-soluble polymer, it is possible to reduce the inhalation irritation during the use of an aerosol product for harmful microorganism control using the harmful microorganism control composition.

[0051] <Control component> The control component is capable of exerting an effect (control effect) of controlling harmful microorganisms. In the present embodiment, in addition to the effect of preventing propagation by creating an environment in which harmful microorganisms are unlikely to grow or exist, the effect of preventing propagation by killing harmful microorganisms is referred to as the control effect. For example, when controlling mold, the anti-mold effect and the fungicidal effect are included in the control effect. The control component can be used alone as one kind, or can also be used as a mixture of two or more kinds. In addition, in the control component, when there are optical isomers based on asymmetric carbon or geometric isomers based on double bonds, each of them and any mixture thereof are also included in the present invention.

[0052] As the controlling ingredient, quaternary ammonium salts (e.g., benzalkonium chloride, benzalkonium methosulfate, benzalkonium organic acid salts such as benzalkonium salts, benzetonium chloride, benzetonium methosulfate, benzetonium organic acid salts such as benzetonium salts, cetylpyridinium chloride, cetylpyridinium methosulfate, cetylpyridinium organic acid salts such as cetylpyridinium salts, didecyldimethylammonium chloride, didecyldimethylammonium methosulfate such as didecyldimethylammonium salts, dilauryl dimethylammonium chloride, dilauryl dimethylammonium methosulfate such as dilauryl dimethylammonium salts, distearyldimethylammonium chloride, distearyldimethylammonium methosulfate such as distearyldimethylammonium salts), 1,4-bis[3,3´-(1-decylpyridinium)methyloxy]butane dibromide, 1,4-bis[3,3´-(1-decylpyridinium)methyloxy]butane dichloride, 1,4-bis[3,3´-(1-decylpyridinium)methyloxy]butane dimethosulfate and other 1,4-bis[3,3´-(1-decylpyridinium)methyloxy]butane salts and other cationic controlling ingredients (more specifically, cationic surfactant-based controlling ingredients), glyceryl monolaurate (monolaurin), glyceryl monocaprylate (monocaprylin), glyceryl monocaprate (monocaprin) and other glyceryl monofatty acid ester-based controlling ingredients, isopropylmethylphenol (IPMP), carvacrol, thymol, triclosan, methylparaben, ethylparaben, propylparaben, butylparaben, 4-chloro-3,Phenolic control components such as 5 - dimethylphenol, orthophenylphenol, o - cresol, m - cresol, and p - cresol, biguanide - based control components, azole - based control components such as tebuconazole and enilconazole, fruit seed extract - based control components such as grapefruit seed extract, kaki seed extract, and grape seed extract, chlorhexidine salts such as chlorhexidine gluconate and chlorhexidine hydrochloride, chlorhexidine - based control components such as chlorhexidine, silicon - based control components such as octadecyldimethyl(3 - triethoxysilylpropyl)ammonium chloride, dodecyldimethyl(3 - triethoxysilylpropyl)ammonium chloride, dodecyldiisopropyl(3 - triethoxysilylpropyl)ammonium chloride, tetradecyldimethyl(3 - triethoxysilylpropyl)ammonium chloride, tetradecyldiethyl(3 - triethoxysilylpropyl)ammonium chloride, tetradecyldi - n - propyl(3 - triethoxysilylpropyl)ammonium chloride, pentadecyldimethyl(3 - triethoxysilylpropyl)ammonium chloride, pentadecyldiethyl(3 - triethoxysilylpropyl)ammonium chloride, pentadecyldi - n - propyl(3 - triethoxysilylpropyl)ammonium chloride, hexadecyldimethyl(3 - triethoxysilylpropyl)ammonium chloride, hexadecyldiethyl(3 - triethoxysilylpropyl)ammonium chloride, hexadecyldi - n - propyl(3 - triethoxysilylpropyl)ammonium chloride, octadecyldiethyl(3 - triethoxysilylpropyl)ammonium chloride, octadecyldi - n - propyl(3 - triethoxysilylpropyl)ammonium chloride, carboxylic acid - based control components or their salts such as benzoic acid, salicylic acid, sorbic acid, ethylenediaminetetraacetic acid (EDTA), glycine, alkyldiethylaminoglycine, polylysine, silver - based control components such as dehydroacetic acid, chloramine, 3 - iodo - 2 - propyl - N - butylcarbamate (IPBC), phenoxyethanol, silver zeolite, zinc pyrithione, thiamine lauryl sulfate, white egg protein, hydroxyalkyl chitosan or its salts, etc. are included.,

[0053] Among these control components, cationic control components, glycerin monofatty acid ester-based control components, phenolic control components, quaternary ammonium salts, and azole-based control components are preferable, and benzalkonium chloride, 1,4-bis[3,3´-(1-decylpyridinium)methyloxy]butane dibromide, glyceryl monolaurate (monolaurin), and glyceryl monocaprylate (monocaprylin) are more preferable. By including at least one selected from the group consisting of cationic control components, glycerin monofatty acid ester-based control components, phenolic control components, quaternary ammonium salts, and azole-based control components as the control component in the harmful microorganism control composition, the inhalation irritation caused by cationic control components, glycerin monofatty acid ester-based control components, phenolic control components, quaternary ammonium salts, and azole-based control components can be reduced. Therefore, by selecting these control components, the inhalation irritation reduction effect of the aerosol product for harmful microorganism control using the harmful microorganism control composition and the effect of the above-described inhalation irritation reducing agent can be more easily felt.

[0054] <At least one selected from the group consisting of fatty acid esters, aromatic carboxylic acid esters, dibasic acid esters, saturated acyclic alcohols having 3 to 22 carbon atoms, hydrocarbon solvents, glycol solvents, and water-soluble polymers> Fatty acid esters, aromatic carboxylic acid esters, dibasic acid esters, saturated acyclic alcohols having 3 to 22 carbon atoms, hydrocarbon solvents, glycol solvents, and water-soluble polymers can be expected to have the same effects as the active ingredients of the above-described inhalation irritation reducing agent, and the same ones as the fatty acid esters, aromatic carboxylic acid esters, dibasic acid esters, saturated acyclic alcohols having 3 to 22 carbon atoms, hydrocarbon solvents, glycol solvents, and water-soluble polymers which are the active ingredients can be used. Also, similar to the inhalation irritation reducing agent, it can itself be used as the solvent of the harmful microorganism control composition. Therefore, in order to avoid duplicate descriptions, detailed explanations of these components are omitted.

[0055] <Content of the controlling ingredient, and content of at least one selected from the group consisting of fatty acid esters, aromatic carboxylic acid esters, dibasic acid esters, saturated acyclic alcohols having 3 to 22 carbon atoms, hydrocarbon solvents, glycol solvents, and water-soluble polymers> The content of at least one selected from the group consisting of fatty acid esters, aromatic carboxylic acid esters, dibasic acid esters, saturated acyclic alcohols having 3 to 22 carbon atoms, hydrocarbon solvents, glycol solvents, and water-soluble polymers per 1 part by mass of the controlling ingredient is preferably 0.1 to 2000 parts by mass, more preferably 0.2 to 2000 parts by mass, and even more preferably 4 to 56 parts by mass. That is, the mass ratio (a / b) of the controlling ingredient (a) to at least one (b) selected from the group consisting of fatty acid esters, aromatic carboxylic acid esters, dibasic acid esters, saturated acyclic alcohols having 3 to 22 carbon atoms, hydrocarbon solvents, glycol solvents, and water-soluble polymers is preferably 1 / 2000 to 1 / 0.1, more preferably 1 / 2000 to 1 / 0.2, and even more preferably 1 / 56 to 1 / 4, similar to the mass ratio (a / b) of the above-mentioned controlling ingredient (a) to the inhalation irritation reducing agent (b). By setting the content of at least one selected from the group consisting of fatty acid esters, aromatic carboxylic acid esters, dibasic acid esters, saturated acyclic alcohols having 3 to 22 carbon atoms, hydrocarbon solvents, glycol solvents, and water-soluble polymers within the above range, the irritation derived from the controlling ingredient during the use of the aerosol product for controlling harmful microorganisms using the composition for controlling harmful microorganisms can be further reduced.

[0056] The content of each at least one selected from the group consisting of a control component, a fatty acid ester, an aromatic carboxylic acid ester, a dibasic acid ester, a saturated acyclic alcohol having 3 to 22 carbon atoms, a hydrocarbon solvent, a glycol solvent, and a water-soluble polymer in the composition for controlling harmful microorganisms can be appropriately set so that the above-mentioned mass ratio (a / b) is within the above range. For example, the content of the control component in the composition for controlling harmful microorganisms is preferably 0.05 to 50 w / v%, more preferably 0.1 to 30 w / v%. By setting the content of the control component within the above range, the control effect of the aerosol product for controlling harmful microorganisms using the composition for controlling harmful microorganisms can be further enhanced. The content of at least one selected from the group consisting of a fatty acid ester, an aromatic carboxylic acid ester, a dibasic acid ester, a saturated acyclic alcohol having 3 to 22 carbon atoms, a hydrocarbon solvent, a glycol solvent, and a water-soluble polymer in the composition for controlling harmful microorganisms is preferably 0.1 to 99.9 w / v%, more preferably 5 to 99.9 w / v%, and even more preferably 10 to 99.9 w / v%. By setting the content of at least one selected from the group consisting of a fatty acid ester, an aromatic carboxylic acid ester, a dibasic acid ester, a saturated acyclic alcohol having 3 to 22 carbon atoms, a hydrocarbon solvent, a glycol solvent, and a water-soluble polymer within the above range, the inhalation irritation during the use of the aerosol product for controlling harmful microorganisms using the composition for controlling harmful microorganisms can be further reduced.

[0057] (Solvent) A composition for controlling harmful microorganisms is usually in a state where an active ingredient is dissolved or dispersed in an organic solvent as a solvent. Examples of the organic solvent include alcohols having 2 carbon atoms (ethanol), alcohols having a branched chain of 3 carbon atoms (isopropanol), glycol ether solvents having 3 to 10 carbon atoms such as diethylene glycol monobutyl ether, ketone solvents such as acetone and methyl isobutyl ketone, and the like. Among these, from the viewpoint of the feeling of use such as stickiness after treatment, it is preferable to contain ethanol and isopropanol, and it is more preferable to contain ethanol. When the composition for controlling harmful microorganisms is used as an aerosol product, if water is used as a solvent, the compatibility between water and the propellant is extremely poor, and it may be difficult to appropriately form spray particles of the composition for controlling harmful microorganisms during spraying. In this case, it is preferable that the composition for controlling harmful microorganisms does not contain water as a solvent. The solvent can be used alone or as a mixture of two or more kinds.

[0058] (Other components) The composition for controlling harmful microorganisms is at least one selected from the group consisting of the above-described control components, fatty acid esters, aromatic carboxylic acid esters, dibasic acid esters, saturated acyclic alcohols having 3 to 22 carbon atoms, hydrocarbon solvents, glycol solvents, and water-soluble polymers. As components other than the solvent, if necessary, it may contain pest control components, pH adjusters, nonionic surfactants, anionic surfactants, cationic surfactants, synergists for pest control components such as synergists for pyrethroid compounds, fragrances, etc. In addition, it may contain antioxidants such as butylhydroxytoluene, stabilizers such as monoethanolamine, triethanolamine, citric acid, citrate, sodium edetate, ascorbic acid, inorganic powders such as talc and silicic acid, deodorants, pigments, feel imparting agents, UV absorption inhibitors, antistatic agents, defoaming agents, excipients, fragrances, etc.

[0059] (Kinematic viscosity of the composition for controlling harmful microorganisms at 20°C) The kinematic viscosity of the composition for controlling harmful microorganisms (aerosol stock solution) at 20°C is 4 to 8 mm 2It is preferably adjusted to be 4.5 to 7 mm / s, more preferably 5 to 6.5 mm / s, and even more preferably 5 to 6.5 mm / s. By setting the kinematic viscosity within the above range, when the composition for controlling harmful microorganisms is sprayed, it appropriately acts on the particle size of the spray particles, and the inhalation irritation during the use of the aerosol product for controlling harmful microorganisms using the composition for controlling harmful microorganisms can be further reduced. The above kinematic viscosity can be calculated by the following formula (I). 2 / s is more preferable, and 5 to 6.5 mm 2 / s is even more preferable. By setting the kinematic viscosity within the above range, when the composition for controlling harmful microorganisms is sprayed, it appropriately acts on the particle size of the spray particles, and the inhalation irritation during the use of the aerosol product for controlling harmful microorganisms using the composition for controlling harmful microorganisms can be further reduced. The above kinematic viscosity can be calculated by the following formula (I). The kinematic viscosity of the aerosol stock solution at 20 ° C [mm 2 / s = cSt] = (viscosity η of the aerosol stock solution at 20 ° C [mPa · s]) / (density of the aerosol stock solution at 20 ° C [g / mL]) ··· (I)

[0060] The viscosity η of the composition for controlling harmful microorganisms (aerosol stock solution) at 20 ° C can be measured by various viscometers. For example, the composition for controlling harmful microorganisms placed in a beaker is adjusted to 20 ° C in a constant temperature water bath (manufactured by IWAKI Co., Ltd.), and a B-type viscometer (manufactured by Tokyo Keiki Co., Ltd., rotor No. 1) is used to measure the viscosity at 20 ° C (measurement conditions: 60 rpm, 30 seconds). In addition, the density of the composition for controlling harmful microorganisms at 20 ° C can be calculated from the mass and volume (capacity) of the adjusted composition for controlling harmful microorganisms, or it may be calculated in consideration of the blending ratio based on each component contained in the composition for controlling harmful microorganisms.

[0061] [Form of application of the composition for controlling harmful microorganisms] The composition for controlling harmful microorganisms can be prepared as an aerosol product for controlling harmful microorganisms by enclosing the composition for controlling harmful microorganisms and a propellant in a pressure-resistant container.

[0062] [Aerosol product for controlling harmful microorganisms] The aerosol product for controlling harmful microorganisms of the present embodiment has a pressure-resistant container and an aerosol composition filled in the pressure-resistant container. The aerosol composition contains a stock solution for controlling harmful microorganisms and a propellant. The stock solution for controlling harmful microorganisms is the above-described composition for controlling harmful microorganisms. The volume ratio (A / B) of the stock solution for controlling harmful microorganisms (aerosol stock solution) (A) to the propellant (B), the injection volume per injection (also referred to as "injection volume"), the injection force, etc. can be set as appropriate.

[0063] According to the aerosol product for controlling harmful microorganisms of the present embodiment, since the aerosol composition filled in the pressure-resistant container contains the above-described composition for controlling harmful microorganisms as a stock solution for controlling harmful microorganisms, the irritation derived from the control component during the use of the aerosol product for controlling harmful microorganisms can be reduced.

[0064] The aerosol product for controlling harmful microorganisms is preferably a metered-dose aerosol product. Since the aerosol product for controlling harmful microorganisms is a metered-dose aerosol product, an appropriate amount of aerosol can be injected by setting the number of injections according to the volume of the treatment space. Therefore, excessive use of the stock solution for controlling harmful microorganisms (composition for controlling harmful microorganisms) can be suppressed, and inhalation irritation can be reduced efficiently.

[0065] <Propellant> Examples of the propellant include liquefied gases such as liquefied petroleum gas (LPG), dimethyl ether (DME), and hydrofluoroolefins such as HFO1234ze, nitrogen gas, carbon dioxide gas, nitrous oxide, compressed air, and the like.

[0066] <Treatment space> The space to be treated by the aerosol product for controlling harmful microorganisms of the present embodiment can be applied to either outdoor or indoor spaces. As the indoor space, a gap space of less than 2.0 m 3 a narrow space of about 2.0 to 18.8 m 3 a small indoor space with a volume corresponding to a room of about 4.5 to 8 tatami mats of 18.8 to 33.3 m 3 a volume corresponding to a room of about 8 to 16 tatami mats of 33.3 to 66.6 m 3Examples include relatively large indoor spaces and the like. Specifically, for example, closets, cupboards, chests of drawers, sideboards, toilets, bathrooms, storage rooms, living rooms, dining rooms, warehouses, the interiors of vehicles, furniture, and gaps between furniture can be mentioned, but it is not particularly limited. Among these spaces, use in narrow spaces with a volume of 2.0 to 18.8 m 3 is more effective. For example, sealed or semi-sealed spaces such as bathrooms, dressing rooms, washrooms, toilets, cupboards, closets, automobiles, tents, warehouses, storage rooms, garages, and entrances can be mentioned. More specifically, for example, narrow spaces with a volume of 2.0 to 3.0 m 3 include toilets and the like as narrow spaces, and bathrooms and the like can be mentioned as narrow spaces with a volume of 3.0 to 18.8 m 3 .

Examples

[0067] Hereinafter, the present invention will be described in more detail with reference to examples and comparative examples, but the present invention is not limited to the examples.

[0068] [Examples 1 to 46, Comparative Examples 1 to 7] According to the formulations shown in Tables 1 to 9, 100 mL of the harmful microorganism control composition (aerosol stock solution) of Examples 1 to 46 and Comparative Examples 1 to 7 was prepared by making up to the mark in a 100 mL volumetric flask. 20 mL of the aerosol stock solution (A) and 20 mL of liquefied petroleum gas (B) as a propellant were pressure-filled into an aerosol container (pressure-resistant container) with a metering valve having an injection volume of 0.4 mL so that the volume ratio (A / B) was 50 / 50, to prepare the aerosol products for controlling harmful microorganisms of Examples 1 to 46 and Comparative Examples 1 to 7. As the control component, 1,4-bis[3,3´-(1-decylpyridinium)methyloxy]butane dibromide (Compound A), which is commercially available under the product name Hygienia S-100 (manufactured by Tama Chemical Industry Co., Ltd.), was used as a cationic control component. Also, as a glycerin mono-fatty acid ester-based control component, glyceryl monocaprate (monocaprate), which is commercially available under the product name Poem M-200 (manufactured by Riken Vitamin Co., Ltd.), and glyceryl monolaurate, which is commercially available under the product name Poem M-300 (manufactured by Riken Vitamin Co., Ltd.), were used. As the quaternary ammonium salt, benzalkonium chloride, which is commercially available under the product name Cation F2-50R (manufactured by NOF Corporation), was used. As an azole-based control component, tebuconazole, which is commercially available under the product name Bioside R-BP20 (manufactured by Taisho Technos Co., Ltd.), was used. Anhydrous ethanol was used as the ethanol of the solvent. p-Menthan-3,8-diol was used as a saturated cyclic alcohol having 3 to 22 carbon atoms (saturated aliphatic cyclic alcohol having 3 to 22 carbon atoms).

[0069] Using the aerosol products for controlling harmful microorganisms of Examples 1 to 46 and Comparative Examples 1 to 7, the effect of reducing inhalation irritation by an inhalation irritant reducer was evaluated according to the following evaluation method. The results are shown in Tables 1 to 9. Among the above Examples 1 to 46 and Comparative Examples 1 to 7, the kinematic viscosity (unit: mm 2 / s) of the aerosol stock solutions of Examples 2, 3, 5, 8, 19, 38, 39, 40 to 46 and Comparative Examples 1, 4 to 7 at 20 °C was measured according to the following measurement method. The results are shown in Tables 7 to 9. Table 7 shows the transcribed contents of Examples 2, 3, 5, 8, 19, 38, 39 and Comparative Example 1 in Tables 1, 3, 6.

[0070] [Inhalation Stimulation Reduction Effect Evaluation Test] Volume 4 m 3 (Area 2 m 2 , height 2 m), after spraying the aerosol product for controlling harmful microorganisms 5 times from the entrance into the space in the bathroom, 4 pre-trained professional evaluators entered the bathroom and conducted a sensory evaluation on the stimulation (inhalation stimulation) when inhaling. In the sensory evaluation, the stimulation recognized by each evaluator was scored (pointed) with one of 1 point, 3 points, 5 points, and 7 points according to the following evaluation criteria, and after calculating the average value of the scores of the 4 evaluators, it was evaluated according to the following judgment criteria.

[0071] [Evaluation Criteria for Inhalation Stimulation] Score 1: Feeling there is inhalation stimulation Score 3: Feeling a certain degree of stimulation Score 5: Slightly feeling stimulation Score 7: Not feeling stimulation

[0072] [Judgment Criteria for Average Value] - : Average value is 1.0 or more and less than 2.0 (poor) ± : Average value is 2.0 or more and less than 3.0 (ordinary) + : Average value is 3.0 or more and less than 5.0 (slightly good) ++ : Average value is 5.0 or more and less than 6.0 (good) +++ : Average value is 6.0 or more and 7.0 or less (extremely good)

[0073] [Measurement of Kinematic Viscosity of Aerosol Stock Solution at 20 °C] As described above, before preparing the aerosol stock solution (composition for controlling harmful microorganisms) by making it up to the mark in a 100 mL volumetric flask, the mass S0 (tare) of the volumetric flask used at 20 °C was measured in advance. Then, after making it up to the mark, the mass S1 of the aerosol stock solution and the volumetric flask at 20 °C was measured, and the density [g / mL] of the aerosol stock solution at 20 °C was calculated by the following formula (II). Note that 100 mL corresponds to 100 cm 3 corresponding to. Density of aerosol stock solution at 20°C [g / mL] = (Mass S1 - Mass S0) / (100) ··· (II) Put the aerosol stock solution into a 100 mL screw tube, adjust the temperature to 20°C in a constant temperature water bath (manufactured by IWAKI Co., Ltd.), use a B-type viscometer (manufactured by Tokyo Keiki Inc., rotor No. 1), and measure the viscosity η [mPa·s] of the aerosol stock solution at 20°C (measurement conditions: 60 rpm, 30 seconds). Then, according to the measurement method of the kinematic viscosity of the above-mentioned composition for controlling harmful microorganisms (aerosol stock solution) at 20°C, the kinematic viscosity (mm 2 / s) at 20°C was calculated by the above-mentioned formula (I).

[0074]

Table 1

[0075]

Table 2

[0076]

Table 3

[0077]

Table 4

[0078]

Table 5

[0079]

Table 6

[0080]

Table 7

[0081]

Table 8

[0082]

Table 9

[0083] It has been shown that the aerosol products for controlling harmful microorganisms in Examples 1 to 46 using an inhalation irritation reducing agent containing a fatty acid ester, an aromatic carboxylic acid ester, a dibasic acid ester, a saturated acyclic alcohol having 3 to 22 carbon atoms, a hydrocarbon solvent, a glycol solvent, or a water-soluble polymer as an active ingredient have reduced inhalation irritation. Also, it has been shown that inhalation irritation is reduced by the inhalation irritation reducing agent whether one kind of control component is used alone or a mixture of two or more kinds is used. Furthermore, in the aerosol products for controlling harmful microorganisms in Examples 1 to 46, although the results show that inhalation irritation is reduced when one kind of compound is used alone as the active ingredient of the inhalation irritation reducing agent, it is reasonably inferred that inhalation irritation is also reduced when a plurality of kinds of compounds are mixed and used, similar to the case of using one kind of compound alone.

[0084] On the other hand, the aerosol products for controlling harmful microorganisms in Comparative Examples 1 to 7 that do not use an inhalation irritation reducing agent resulted in no reduction of inhalation irritation.

[0085] From the comparison between Examples 2, 3, 5, 8, 19, 38, 39, 40 to 46 and Comparative Examples 1, 4 to 7, it has been shown that by adjusting the kinematic viscosity at 20°C of the composition for controlling harmful microorganisms (aerosol stock solution) to 4 to 8 mm 2 / s, inhalation irritation can be more effectively suppressed. Also, from the comparison between Example 44 and Example 46 and the comparison between Example 1 and Example 46, it has been shown that a synergistic effect can be exerted by the combination of the inhalation irritation reducing agent and the water-soluble polymer.

[0086] Note that water has extremely poor compatibility with the propellant. When they are combined, the spray particles of the composition for controlling harmful microorganisms cannot be properly formed during spraying. Therefore, it is preferable that the aerosol product for controlling harmful microorganisms does not contain water as a solvent. Also, although detailed experimental results are omitted, when the content of a water-soluble polymer such as polyvinyl alcohol increases to about 1.5 w / v%, the viscosity becomes too high and injection failure tends to occur. Therefore, the content of the water-soluble polymer is preferably appropriately set so that injection failure does not occur.

Industrial Applicability

[0087] The inhalation stimulant reducer, the composition for controlling harmful microorganisms, and the aerosol product for controlling harmful microorganisms of the present invention can reduce the irritation caused by inhalation of the spray particles from the aerosol product for controlling harmful microorganisms, and thus can be used for the purpose of extensive control of harmful microorganisms.

Claims

1. An inhalation irritation reducer that reduces irritation caused by a control component when using an aerosol product for controlling harmful microorganisms, The inhalation irritation reducer comprises, as an active ingredient, at least one selected from the group consisting of fatty acid esters, aromatic carboxylate esters, dibasic acid esters, saturated acyclic alcohols having 3 to 22 carbon atoms, hydrocarbon solvents, glycol solvents, and water-soluble polymers.

2. The inhalation irritation reducer according to claim 1, wherein the control component comprises at least one selected from the group consisting of a cationic control component, a glycerin mono fatty acid ester control component, a phenolic control component, a quaternary ammonium salt, and an azole control component.

3. 2. The inhalation irritation reducing agent according to claim 1, wherein the fatty acid ester comprises at least one selected from the group consisting of isopropyl myristate, 2-ethylhexyl palmitate, isopropyl palmitate, ethyl hexanoate, allyl heptanoate, and butyl stearate.

4. The inhalation irritation reducing agent according to claim 1, wherein the amount used is 0.1 to 2000 parts by mass per 1 part by mass of the control component.

5. The inhalation irritation reducing agent according to claim 1, wherein the aerosol product for controlling harmful microorganisms is a metered-dose aerosol product.

6. A pest control component, At least one selected from the group consisting of fatty acid esters, aromatic carboxylate esters, dibasic acid esters, saturated acyclic alcohols having 3 to 22 carbon atoms, hydrocarbon solvents, glycol solvents, and water-soluble polymers; A composition for controlling harmful microorganisms comprising the compound.

7. The harmful microorganism control composition according to claim 6, wherein the control component comprises at least one selected from the group consisting of a cationic control component, a glycerin mono fatty acid ester control component, a phenolic control component, a quaternary ammonium salt, and an azole control component.

8. The harmful microorganism control composition according to claim 6, wherein the fatty acid ester comprises at least one selected from the group consisting of isopropyl myristate, 2-ethylhexyl palmitate, isopropyl palmitate, ethyl hexanoate, allyl heptanoate, and butyl stearate.

9. The harmful microorganism control composition according to claim 6, wherein the content of at least one selected from the group consisting of fatty acid esters, aromatic carboxylic acid esters, dibasic acid esters, saturated acyclic alcohols having 3 to 22 carbon atoms, hydrocarbon solvents, glycol solvents, and water-soluble polymers is 0.1 to 2000 parts by mass per part by mass of the control component.

10. Dynamic viscosity at 20°C is 4 to 8 mm ２ The harmful microorganism control composition according to claim 6, wherein the pesticide concentration is adjusted to be / s.

11. The harmful microorganism control composition according to claim 6, which has reduced inhalation irritation.

12. A pressure vessel; an aerosol composition filled in the pressure-resistant container; having The aerosol composition comprises a harmful microorganism control concentrate and a propellant, The harmful microorganism control concentrate is an aerosol product for controlling harmful microorganisms, which is a harmful microorganism control composition according to any one of claims 6 to 11.

13. The aerosol product for controlling harmful microorganisms according to claim 12, which is a metered dose aerosol product.

14. The aerosol product for controlling harmful microorganisms according to claim 12, which has reduced inhalation irritation.

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