Phosphocholine-containing cosmetic

Abstract

To provide a novel application of phosphocholine, namely in cosmetics, and further to solve the problem that, in using phosphocholine for cosmetic applications, evaporation of water tends to cause crystal precipitation of phosphocholine, and the feeling upon use is not always satisfactory.SOLUTION: This invention has been completed based on the finding that phosphocholine has useful effects in cosmetic applications, such as promoting cholesterol synthesis and exhibiting antibacterial activity, and that a cosmetic containing the following components (A) and (B) solves the problems of crystal precipitation of phosphocholine and feeling upon use: (A) phosphocholine; and (B) a compound that forms a deep eutectic solvent with the component (A).SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to a cosmetic containing phosphocholine.

Background Art

[0002] Phosphocholine is a compound in which one molecule of choline group is bonded to phosphoric acid. In vivo, it is known as an intermediate in the biosynthetic pathways such as phosphatidylcholine and sphingomyelin, and is also known to be involved in immune reactions as one of the binding targets of C-reactive protein. Thus, phosphocholine is a biocompatible component, but industrially, it is only known for use as a synthetic intermediate raw material for pharmaceuticals and the like.

[0003] Deep eutectic solvents are a general term for compositions that are liquid at room temperature obtained by mixing a hydrogen bond acceptor compound and a hydrogen bond donor compound. Even if one or both of the hydrogen bond acceptor compound and the hydrogen bond donor compound are solid at room temperature, a eutectic melting point depression occurs by mixing, and it is characterized in that a liquid state can be created at room temperature. Deep eutectic solvents are known to have characteristics similar to ionic liquids, but are excellent in that they can be obtained at a lower cost than ionic liquids and can be obtained from compounds with less environmental impact and toxicity than ionic liquids, and are expected to be used as a new solvent to replace ionic liquids. Choline chloride is generally known as a hydrogen bond acceptor compound that forms a deep eutectic solvent, but choline chloride has concerns about its use in cosmetics from the viewpoint of irritation. On the other hand, it is not known to use phosphocholine as a hydrogen bond acceptor compound of a deep eutectic solvent.

[0004] As an example of the application of deep eutectic solvents to cosmetics, Patent Document 1 describes that a deep eutectic solvent composed of one or more selected from alkyl betaine, polyhydric alcohol, urea, and urea derivatives promotes the penetration of skin condition-improving components. Patent Document 2 describes that a deep eutectic solvent composed of low-molecular betaine and polyhydric alcohol promotes the penetration of skin condition-improving components. Patent Document 3 describes that a deep eutectic solvent composed of choline chloride and urea promotes the swelling of hair fibers as a solvent for hair treatment and contributes to the modification of hair properties. Patent Document 4 describes that a deep eutectic solvent composed of citric acid and a urea compound reduces the frizz of hair and strengthens damaged hair. Further, in addition to the effects described above, the formation of a deep eutectic solvent is a phenomenon in which a compound that is usually solid at room temperature becomes liquid at room temperature. Therefore, due to such a phenomenon, it is considered that the physical and chemical properties of the compound change greatly. Thus, various useful effects are expected to be exhibited in the use of cosmetics.

Prior Art Documents

Patent Documents

[0005]

Patent Document 1

Patent Document 2

Patent Document 3

Patent Document 4

Summary of the Invention

Problems to be Solved by the Invention

[0006] An object of the present invention is to provide a new use of phosphocholine.

[0007] In addition, when the applicant of the present application uses phosphocholine for cosmetic purposes, it has been found that phosphocholine easily precipitates crystals as moisture evaporates, and the usability is not always sufficient. One of the problems to be solved by the present invention is to solve such problems.

Means for Solving the Problems

[0008] As a result of intensive studies to solve the above problems, the present inventors have found useful effects of phosphocholine in cosmetic applications and completed the present invention.

[0009] In addition, the present inventors have found that a cosmetic containing the following components (A) and (B) solves the problems such as crystal precipitation and usability of the aforementioned phosphocholine, and completed the present invention. (A) Phosphocholine (B) A compound that forms a deep eutectic solvent with component (A)

Effects of the Invention

[0010] The phosphocholine used in the present invention has excellent cholesterol synthesis promoting action and antibacterial action. Since these effects are useful effects in cosmetic applications, phosphocholine can preferably be used in cosmetics.

[0011] In addition, the phosphocholine used in the present invention forms a deep eutectic solvent with various hydrogen bond donor compounds as a hydrogen bond acceptor compound. Thereby, crystal precipitation accompanying the evaporation of moisture of phosphocholine can be suppressed, and the usability of phosphocholine can be improved.

Modes for Carrying Out the Invention

[0012] The cosmetic of the present invention is characterized by containing phosphocholine. Phosphocholine is a compound in which one molecule of choline group is bonded to phosphoric acid via a phosphoester bond. Its melting point is about 110°C, and it is a solid compound at room temperature. The phosphocholine used in the present invention may be in the form of a salt. The production method of phosphocholine is not particularly limited, and those produced by known production methods can be used. Phosphocholine is generally commercially available, and such commercial products can preferably be used in the present invention.

[0013] The phosphocholine used in the present invention has an excellent cholesterol synthesis promoting effect. Since cholesterol, together with ceramide, plays an important role in the skin barrier function as a main component of the intercellular lipids in the stratum corneum, promoting the synthesis of cholesterol leads to an improvement in the skin barrier function.

[0014] The phosphocholine used in the present invention has an excellent antibacterial effect. Therefore, phosphocholine can prevent the growth of skin bacteria, keep the skin healthy, and improve the preservative efficacy of the preparation against bacteria.

[0015] The amount of phosphocholine incorporated into the cosmetic of the present invention is not particularly limited, but is usually 0.001 to 50% by mass, preferably 0.005 to 25% by mass, and more preferably about 0.01 to 10% by mass.

[0016] Another form of the cosmetic of the present invention is characterized by containing the following components (A) and (B). (A) Phosphocholine (B) A compound that forms a deep eutectic solvent with component (A)

[0017] The details of the phosphocholine of component (A) used in the present invention are as described above. However, phosphocholine is characterized by forming a deep eutectic solvent with a hydrogen bond donor compound as a hydrogen bond acceptor compound.

[0018] As the component (B) used in the cosmetic of the present invention, there is no particular limitation as long as it is a hydrogen bond donor compound that forms a deep eutectic solvent with phosphocholine of the component (A) which is a hydrogen bond acceptor compound. More specific compounds of the component (B) are the following components (B1) to (B8). (B1) Polyhydric alcohols (B2) Sugars (B3) Organic acids (B4) Dibasic acids (B5) Aromatic alcohols or aromatic carboxylic acids (B6) Ascorbic acids (B7) Organic amines (B8) Organic amides

[0019] As the polyhydric alcohols of component (B1), more specifically, ethylene glycol, propylene glycol, 1,3-propanediol, 1,2-butylene glycol, 1,3-butylene glycol, 2,3-butylene glycol, tetramethylene glycol, hexylene glycol, octylene glycol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-decanediol, glycerin, trimethylolpropane, 1,2,6-hexanetriol, sorbitol, xylitol, erythritol, inositol, maltitol, mannitol, ethyl glycerin, butyl glycerin, hexyl glycerin, ethylhexyl glycerin, cyclohexyl glycerin, diethylene glycol, triethylene glycol, tetraethylene glycol, polyethylene glycol, dipropylene glycol, tripropylene glycol, polypropylene glycol, diglycerin, triglycerin, tetraglycerin, polyglycerin, isosorbide, etc. may be mentioned. These may be used alone or in combination of two or more. Among these, from the viewpoint of more exerting the effects of the present invention, propylene glycol, 1,3-propanediol, 1,3-butylene glycol, 1,2-pentanediol, glycerin, sorbitol, xylitol, erythritol, inositol, maltitol, mannitol, dipropylene glycol, diglycerin, isosorbide, etc. are mentioned as preferable ones.

[0020] As the saccharides of component (B2), more specifically, xylose, galactose, glucose, mannose, fructose, maltose, trehalose, lactose, sucrose, glucosamine, N-acetylglucosamine, alkyl glucoside, glyceryl glucoside, arbutin, etc. may be mentioned. These may be used alone or in combination of two or more. Among these, from the viewpoint of more exerting the effects of the present invention, glucose, fructose, maltose, trehalose, lactose, sucrose, alkyl glucoside, glyceryl glucoside, arbutin, etc. are mentioned as preferable ones.

[0021] As the organic acids of component (B3), more specifically, acetic acid, propionic acid, butyric acid, valeric acid, caproic acid, glycolic acid, lactic acid, malic acid, tartaric acid, citric acid, gluconic acid, levulinic acid, glutamic acid, aspartic acid, phytic acid, etc. can be mentioned. These may be used alone or in combination of two or more. Among these, from the viewpoint of more effectively exerting the effects of the present invention, glycolic acid, lactic acid, malic acid, tartaric acid, citric acid, gluconic acid, levulinic acid, etc. can be mentioned as preferred ones.

[0022] As the dibasic acids of component (B4), more specifically, oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, azelaic acid, sebacic acid, maleic acid, fumaric acid, cyclohexanedicarboxylic acid, etc. can be mentioned. These may be used alone or in combination of two or more. Among these, from the viewpoint of more effectively exerting the effects of the present invention, succinic acid, glutaric acid, adipic acid, azelaic acid, sebacic acid, etc. can be mentioned as preferred ones.

[0023] As the aromatic alcohols or aromatic carboxylic acids of component (B5), more specifically, phenol, cresol, benzyl alcohol, phenethyl alcohol, phenoxyethanol, dibutylhydroxytoluene, butylhydroxyanisole, thymol, hinokitiol, isopropylmethylphenol, vanillin, propyl gallate, paraoxybenzoic acid ester, benzoic acid, salicylic acid, gallic acid, phthalic acid, caffeic acid, hydroxycaffeic acid, ferulic acid, etc. can be mentioned. These may be used alone or in combination of two or more. Among these, from the viewpoint of more effectively exerting the effects of the present invention, phenoxyethanol, thymol, hinokitiol, isopropylmethylphenol, vanillin, propyl gallate, paraoxybenzoic acid ester, benzoic acid, salicylic acid, gallic acid, ferulic acid, caffeic acid, etc. can be mentioned as preferred ones.

[0024] Examples of the ascorbic acids of component (B6) include, more specifically, ascorbic acid, ascorbic acid phosphate ester, ascorbic acid glucoside, ascorbic acid monostearate, ascorbic acid monopalmitate, ascorbic acid dipalmitate and other ascorbic acid fatty acid esters, 2-O-ethyl ascorbic acid, 3-O-ethyl ascorbic acid, 3-O-cetyl ascorbic acid, 2-O-glyceryl ascorbic acid, 3-O-glyceryl ascorbic acid, 2,3-O-glyceryl ascorbic acid and other ascorbic acid alkyl ethers. These may be used alone or in combination of two or more. Among these, from the viewpoint of more effectively exerting the effects of the present invention, ascorbic acid, ascorbic acid phosphate ester, ascorbic acid glucoside, 2-O-ethyl ascorbic acid, 3-O-ethyl ascorbic acid, 3-O-cetyl ascorbic acid, 2-O-glyceryl ascorbic acid, 3-O-glyceryl ascorbic acid, 2,3-O-glyceryl ascorbic acid, etc. are mentioned as preferable ones.

[0025] Examples of the organic amines of component (B7) include, more specifically, monoethanolamine, diethanolamine, triethanolamine, lysine, arginine, histidine, ornithine, creatine, guanidine, tris(hydroxymethyl)aminomethane and the like. These may be used alone or in combination of two or more. Among these, from the viewpoint of more effectively exerting the effects of the present invention, monoethanolamine, diethanolamine, triethanolamine, tris(hydroxymethyl)aminomethane and the like are mentioned as preferable ones.

[0026] Examples of the organic amides of component (B8) include, more specifically, urea, dimethylurea, hydroxyethylurea, allantoin, nicotinamide and the like. These may be used alone or in combination of two or more. Among these, from the viewpoint of more effectively exerting the effects of the present invention, urea, hydroxyethylurea, nicotinamide and the like are mentioned as preferable ones.

[0027] Phosphocholine is a water-soluble component, but since it has crystallinity, crystals precipitate as water evaporates. Then, for example, when a preparation containing phosphocholine adheres to the mouth of a container, a nozzle, etc., there arises a problem that crystals precipitate as water evaporates. Such crystal precipitation is not preferable because it changes the appearance of the product and gives a rough feeling in use. In the cosmetic of the present invention, by blending the above-described component (B) together with phosphocholine, crystal precipitation accompanying the evaporation of water of phosphocholine can be suppressed. The mechanism is presumed to be due to the phenomenon that phosphocholine and component (B) form a deep eutectic solvent, and a compound that is solid at normal temperature in the deep eutectic solvent becomes liquid at normal temperature due to a decrease in the eutectic melting point.

[0028] In the cosmetic of the present invention, by blending the above-described component (B) together with phosphocholine, the feeling in use of phosphocholine after application and drying can be improved. The mechanism is presumed to be due to the phenomenon that phosphocholine and component (B) form a deep eutectic solvent, and a compound that is solid at normal temperature in the deep eutectic solvent becomes liquid at normal temperature due to a decrease in the eutectic melting point.

[0029] Regarding the blending ratio of component (A) and component (B) of the present invention, there is no particular limitation because part or all of phosphocholine forms a deep eutectic solvent at any ratio, and the effects of the present invention due to the formation of the deep eutectic solvent are achieved. From the viewpoint of further exerting the effects of the present invention due to the formation of the deep eutectic solvent, it is preferable to blend component (B) at a ratio of 0.1 to 15 moles, and more preferably at a ratio of 0.15 to 10 moles, per 1 mole of component (A). Depending on the type of component (B), since the range of the ratio for forming the deep eutectic solvent is different, the following blending ratios are given as more preferable ranges. When component (B) is component (B1), it is more preferable to blend component (B1) at a ratio of 0.15 moles to 15 moles, and most preferably at a ratio of 0.2 to 10 moles, per 1 mole of component (A). When component (B) is component (B2), it is more preferable to blend component (B2) in a ratio of 0.1 to 1.7 moles, and most preferably in a ratio of 0.1 to 1.5 moles, per 1 mole of component (A). When component (B) is component (B3), it is more preferable to blend component (B3) in a ratio of 0.15 to 7 moles, and most preferably in a ratio of 0.2 to 5 moles, per 1 mole of component (A). When component (B) is component (B4), it is more preferable to blend component (B4) in a ratio of 0.25 to 1.8 moles, and most preferably in a ratio of 0.33 to 1.5 moles, per 1 mole of component (A). When component (B) is component (B5), it is more preferable to blend component (B5) in a ratio of 0.25 to 2.5 moles, and most preferably in a ratio of 0.33 to 2 moles, per 1 mole of component (A). When component (B) is component (B6), it is more preferable to blend component (B6) in a ratio of 0.15 to 7 moles, and most preferably in a ratio of 0.2 to 5 moles, per 1 mole of component (A). When component (B) is component (B7), it is more preferable to blend component (B7) in a ratio of 0.15 to 7 moles, and most preferably in a ratio of 0.2 to 5 moles, per 1 mole of component (A). When component (B) is component (B8), it is more preferable to blend component (B8) in a ratio of 0.1 to 3.5 moles, and most preferably in a ratio of 0.1 to 3 moles, per 1 mole of component (A).

[0030] When components (A) and (B) are blended in the cosmetic of the present invention to exert the effects of the present invention by forming a deep eutectic solvent, it is desirable that both components (A) and (B) are contained in a volatile solvent in which components (A) and (B) can be dissolved or dispersed. When both components (A) and (B) are contained in the volatile solvent, when the volatile solvent volatilizes and is removed, components (A) and (B) form a deep eutectic solvent, and the effects of the present invention can be more exerted. The volatile solvent is preferably selected from water, ethanol, and mixtures thereof.

[0031] The cosmetic of the present invention may contain, if necessary, water and additive components usually blended in cosmetics, such as oily bases, humectants / sensory improvers, surfactants, polymers / thickeners / gelling agents, antioxidants, reducing agents, oxidizing agents, antioxidants, whitening agents, vitamins and their derivatives, plant / animal / microbial extracts, ultraviolet absorbers, antibacterial / antiseptic agents, chelating agents, pH adjusters / acids / alkalis, solvents / propellants, antipruritics, keratolytic / dissolving agents, antiperspirants, cooling agents, astringents, enzymes, nucleic acids, anti-inflammatory agents, hair growth agents / blood circulation promoters / stimulants, hormones, anti-wrinkle / anti-aging agents, irritation relievers, cooling sensates, warming sensates, powders, pigments / colorants / dyes / pigments, fragrances, etc., to an extent that does not impair the effects of the present invention.

[0032] As the oily base, higher alcohols such as cetyl alcohol, myristyl alcohol, oleyl alcohol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol, arachyl alcohol, behenyl alcohol, jojoba alcohol, chimyl alcohol, ceraryl alcohol, batyl alcohol, hexyl decanol, isostearyl alcohol, 2-octyldodecanol, dimer diol, etc.; aralkyl alcohols such as benzyl alcohol and derivatives; higher fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, behenic acid, undecylenic acid, 12-hydroxystearic acid, palmitooleic acid, oleic acid, linoleic acid, linolenic acid, erucic acid, docosahexaenoic acid, eicosapentaenoic acid, isohexadecanoic acid, anteisoheneicosanoic acid, long-chain branched fatty acids, long-chain α-hydroxy fatty acids, dimer acid, hydrogenated dimer acid, etc., and their aluminum salts, calcium salts, magnesium salts, zinc salts, potassium, sodium salts, etc. of metal soaps, and nitrogen-containing derivatives such as amides; hydrocarbons such as liquid paraffin (mineral oil), heavy liquid isoparaffin, light liquid isoparaffin, α-olefin oligomer, polyisobutene, hydrogenated polyisobutene, polybutene, squalane, olive-derived squalane, squalene, petrolatum, solid paraffin, etc.; waxes such as candelilla wax, carnauba wax, rice wax, wood wax, beeswax, montan wax, ozokerite, ceresin, paraffin wax, microcrystalline wax, petrolatum, Fischer-Tropsch wax, polyethylene wax, ethylene-propylene copolymer, etc.; vegetable oils and fats such as coconut oil, palm oil, palm kernel oil, safflower oil, olive oil, castor oil, avocado oil, sesame oil, tea oil, evening primrose oil, wheat germ oil, macadamia nut oil, hazelnut oil, kukui nut oil, rosehip oil, meadowfoam oil, persic oil, tea tree oil, peppermint oil, corn oil, rapeseed oil, sunflower oil, wheat germ oil, linseed oil, cottonseed oil, soybean oil, peanut oil, rice bran oil, cocoa butter, shea butter, hydrogenated coconut oil, hydrogenated castor oil, jojoba oil, hydrogenated jojoba oil, etc.; animal fats and oils such as beef tallow, milk fat, horse fat, egg yolk oil, mink oil, turtle oil, etc.; animal waxes such as whale oil, lanolin, orange raffia oil, etc.;Lanolin derivatives such as liquid lanolin, reduced lanolin, adsorbed and purified lanolin, lanolin acetate, liquid lanolin acetate, hydroxy lanolin, polyoxyethylene lanolin, lanolin fatty acid, hard lanolin fatty acid, lanolin alcohol, lanolin alcohol acetate, cetyl lanolyl acetate, etc.; Sphingolipids such as lecithin, phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, sphingomyelin, etc., phospholipids such as phosphatidic acid, cyclic lysophosphatidic acid or its salts, lysophosphatidylcholine, etc.; Phospholipid derivatives such as hydrogenated soybean phospholipid, partially hydrogenated soybean phospholipid, hydrogenated egg yolk phospholipid, partially hydrogenated egg yolk phospholipid, etc.; Sterols such as cholesterol, dihydrocholesterol, lanosterol, dihydrolanosterol, phytosterol, cholanic acid, etc.; Saponins; Sapogenins; Acyl sarcosine alkyl esters such as cholesteryl acetate, cholesteryl nonanoate, cholesteryl stearate, cholesteryl isostearate, cholesteryl oleate, N-lauroyl-L-glutamic acid di(cholesteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamic acid di(cholesteryl / octyldodecyl), N-lauroyl-L-glutamic acid di(phytosteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamic acid di(phytosteryl / octyldodecyl), N-lauroyl sarcosine isopropyl, etc., sterol esters such as cholesteryl 12-hydroxystearate, cholesteryl macadamia nut oil fatty acid, phytosteryl macadamia nut oil fatty acid, phytosteryl sunflower seed oil fatty acid, phytosteryl isostearate, cholesteryl soft lanolin fatty acid, cholesteryl hard lanolin fatty acid, cholesteryl long-chain branched fatty acid, cholesteryl long-chain α-hydroxy fatty acid, etc.; Lipid complexes such as phospholipid-cholesterol complex, phospholipid-phytosterol complex, etc.;Octyldodecyl myristate, hexyldecyl myristate, octyldodecyl isostearate, cetyl palmitate, octyldodecyl palmitate, cetyl octanoate, hexyldecyl octanoate, isotridecyl isononanoate, isononyl isononanoate, octyl isononanoate, isotridecyl isononanoate, isodecyl neopentanoate, isotridecyl neopentanoate, isostearyl neopentanoate, octyldodecyl neodecanoate, oleyl oleate, octyldodecyl oleate, octyldodecyl ricinoleate, octyldodecyl lanolin fatty acid, dicaprylyl carbonate, hexyldecyl dimethyloctanoate, octyldodecyl erucate, hydrogenated castor oil isostearate, ethyl oleate, ethyl avocado oil fatty acid, isopropyl myristate, isopropyl palmitate, octyl palmitate, isopropyl isostearate, isopropyl lanolin fatty acid, methylheptyl laurate, methylheptyl myristate, methylheptyl palmitate, methylheptyl isostearate, diethyl sebacate, diisopropyl sebacate, dioctyl sebacate, diisopropyl adipate, dibutyloctyl sebacate, diisobutyl adipate, dioctyl succinate, triethyl citrate and other monoalcohol carboxylic acid esters; cetyl lactate, hydrogenated castor oil monoisostearate, γ-elaeolactone, diisostearyl malate and other oxyacid esters;Glyceryl trioctanoate, glyceryl trioleate, glyceryl triisostearate, glyceryl diisostearate, glyceryl tri(caprylic / capric acid), glyceryl tri(caprylic / capric / myristic / stearic acid), hydrogenated rosin triglyceride (hydrogenated ester gum), rosin triglyceride (ester gum), glyceryl behenate eicosanedioate, trimethylolpropane trioctanoate, trimethylolpropane triisostearate, neopentyl glycol dioctanoate, neopentyl glycol dicaprate, 2-butyl-2-ethyl-1,3-propanediol dioctanoate, propylene glycol dioleate, pentaerythrityl tetraoctanoate, hydrogenated rosin pentaerythrityl, ditrimethylolpropane triethylhexanoate, ditrimethylolpropane (isostearic / sebacic acid), pentaerythrityl triethylhexanoate, dipentaerythrityl (hydroxystearic / stearic / rosinic acid), diglyceryl diisostearate, polyglyceryl tetraisostearate, polyglyceryl-10 nonaisostearate, polyglyceryl-8 deca(erucic / isostearic / ricinoleic acid), diglyceryl oligoster ester (hexyldecanoic / sebacic acid), ethylene glycol distearate (distearic acid ethylene glycol), 3-methyl-1,5-pentanediol dineopentanoate, 2,4-diethyl-1,5-pentanediol dineopentanoate and other polyhydric alcohol fatty acid esters; alkyl ethers such as dicaprylyl ether; derivatives of dimer acid or dimer diol such as diisopropyl dimer dilinoleate, diisostearyl dimer dilinoleate, di(isostearyl / phytosteryl) dimer dilinoleate, (phytosteryl / behenyl) dimer dilinoleate, (phytosteryl / isostearyl / cetyl / stearyl / behenyl) dimer dilinoleate, dimer dilinoleyl dimer dilinoleate, diisostearyl dimer dilinoleate, hydrogenated rosin condensate of dimer dilinoleate, hydrogenated castor oil dimer dilinoleate, hydroxyalkyl dimer dilinoleyl etherFatty acid alkanolamides such as coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (palmitamide MEA), palmitic acid diethanolamide (palmitamide DEA), coconut oil fatty acid methylethanolamide (cocamide methyl MEA); silicones such as dimethicone (dimethylpolysiloxane), highly polymerized dimethicone (highly polymerized dimethylpolysiloxane), cyclomethicone (cyclic dimethylsiloxane, decamethylcyclopentasiloxane), phenyltrimethicone, diphenyldimethylsilicone, phenyldimethylsilicone, (aminoethylaminopropylmethylsilicone / dimethylsilicone) copolymer, dimethiconol, dimethiconol cross polymer, silicone resin, silicone rubber, amino-modified silicones such as aminopropyldimethylsilicone and amodimethicone, cation-modified silicone, polyether-modified silicones such as dimethicone copolyol, polyglycerin-modified silicone, sugar-modified silicone, carboxylic acid-modified silicone, phosphoric acid-modified silicone, sulfuric acid-modified silicone, alkyl-modified silicone, fatty acid-modified silicone, alkyl ether-modified silicone, amino acid-modified silicone, peptide-modified silicone, fluorine-modified silicone, cation-modified and polyether-modified silicone, amino-modified and polyether-modified silicone, alkyl-modified and polyether-modified silicone, amidoalkyl-modified silicone, aminoglycol-modified silicone, aminophenyl-modified silicone, polysiloxane-oxyalkylene copolymer; fluorine-based oils such as perfluorodecane, perfluorooctane, perfluoropolyether are preferably mentioned.;

[0033] As the humectant and feel improver, there are polyols such as glycerin, 1,3-butylene glycol, propylene glycol, 3-methyl-1,3-butanediol, 1,3-propanediol, 2-methyl-1,3-propanediol, trimethylolpropane, pentaerythritol, hexylene glycol, diglycerin, polyglycerin, diethylene glycol, polyethylene glycol, dipropylene glycol, polypropylene glycol, ethylene glycol-propylene glycol copolymer, erythritol and their polymers; glycol alkyl ethers such as diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol dibutyl ether; water-soluble esters such as (eicosanedioic acid / tetradecanedioic acid) polyglyceryl-10, tetradecanedioic acid polyglyceryl-10, cyclohexanedicarboxylic acid bisethoxydiglycol; sugar alcohols such as sorbitol, xylitol, erythritol, mannitol, maltitol; sugars and their derivatives such as glucose, fructose, galactose, mannose, threose, xylose, arabinose, fucose, ribose, deoxyribose, maltose, trehalose, glucosyltrehalose, lactose, raffinose, gluconic acid, glucuronic acid, cyclodextrins (α-, β-, γ-cyclodextrin, and modified cyclodextrins such as maltosylated, hydroxyalkylated cyclodextrin), β-glucan, chitin, chitosan, heparin and its derivatives, pectin, arabinogalactan, dextrin, dextran, glycogen, ethyl glucoside, glucosylethyl methacrylate polymer or copolymer; hyaluronic acid, sodium hyaluronate; sodium chondroitin sulfate; mucitin sulfate, caronin sulfate, keratosulfate, dermatan sulfate; extracts of Physalia utriculus, Physalia utriculus polysaccharide; fructans such as inulin, levan; fucoidan; tuberose polysaccharide, natural polysaccharide; organic acids such as citric acid, tartaric acid, lactic acid and their salts; urea; 2-pyrrolidone-5-carboxylic acid and its salts such as sodium salt;Amino acids such as betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, tyrosine, β-alanine, threonine, glutamic acid, glutamine, asparagine, aspartic acid, cysteine, cystine, methionine, leucine, isoleucine, valine, tryptophan, histidine, taurine, γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid, carnitine, carnosine, creatine and their salts; Protein peptides and their derivatives such as collagen, fish-derived collagen, atelocollagen, gelatin, elastin, collagen-degrading peptides, hydrolyzed collagen, hydroxypropylammonium chloride hydrolyzed collagen, elastin-degrading peptides, keratin-degrading peptides, hydrolyzed keratin, conchiolin-degrading peptides, hydrolyzed conchiolin, silk protein-degrading peptides, hydrolyzed silk, lauroyl hydrolyzed silk sodium, soy protein-degrading peptides, wheat protein-degrading peptides, hydrolyzed wheat protein, casein-degrading peptides, acylated peptides; Acylated peptides such as palmitoyl oligopeptide, palmitoyl pentapeptide, palmitoyl tetrapeptide; Silylated peptides; Lactic acid bacteria culture solution, yeast extract, eggshell membrane protein, bovine submandibular gland mucin, hypotaurine, sesame lignan glycoside, glutathione, albumin, whey; Choline chloride; Animal and plant extract components such as placenta extract, aerolastin, collagen, aloe extract, witch hazel water, loofah water, chamomile extract, licorice extract, comfrey extract, silk extract, rosa multiflora extract, digitalis purpurea extract, eucalyptus extract, melilot extract, natural ceramides (type 1, 2, 3, 4, 5, 6), hydroxyceramides, pseudo-ceramides, sphingosine, sphingomyelin, sphingoglycolipids, ceramides and extracts containing glycosphingolipids are preferably mentioned.;

[0034] As the surfactant, anionic surfactants, nonionic surfactants, cationic surfactants, amphoteric surfactants, polymer surfactants, etc. are preferably exemplified. There is no particular limitation on the HLB of the surfactant, and those with a low HLB of about 1 to those with a high HLB of about 20 can be used, and it is also preferable to combine those with a low HLB and those with a high HLB. Examples of preferable surfactants include, among anionic surfactants, fatty acid salts such as potassium laurate and potassium myristate; alkyl sulfate ester salts such as sodium lauryl sulfate, triethanolamine lauryl sulfate, and ammonium lauryl sulfate; polyoxyethylene alkyl sulfate salts such as sodium laureth sulfate and triethanolamine laureth sulfate; acyl N-methyl amino acid salts such as sodium cocoyl methyl taurate, potassium cocoyl methyl taurate, sodium lauroyl methyl taurate, sodium myristoyl methyl taurate, sodium lauroyl methyl alaninate, sodium lauroyl sarcosinate, triethanolamine lauroyl sarcosinate, and sodium lauroyl glutamate methyl alaninate; acyl amino acid salts such as sodium cocoyl glutamate, triethanolamine cocoyl glutamate, sodium lauroyl glutamate, sodium myristoyl glutamate, sodium stearoyl glutamate, ditriethanolamine palmitoyl aspartate, triethanolamine cocoyl alaninate, and lysine Na dilauroyl glutamate; polyoxyethylene alkyl ether acetate salts such as sodium laureth acetate; succinate ester salts such as sodium lauroyl monoethanolamide succinate; fatty acid alkanolamide ether carboxylate salts; acyl lactate salts; polyoxyethylene fatty amine sulfate salts; fatty acid alkanolamide sulfate salts; fatty acid glyceride sulfate salts such as sodium hydrogenated palm oil fatty acid glycerol sulfate; polyoxyethylene alkylbenzene sulfate salts; olefin sulfonate salts such as sodium α-olefin sulfonate; alkyl sulfosuccinate salts such as sodium lauryl sulfosuccinate and sodium dioctyl sulfosuccinate;Alkyl ether sulfosuccinates such as disodium lauryl sulfosuccinate, sodium monolaurylmonoethanolamine polyoxyethylene sulfosuccinate, sodium lauryl polypropylene glycol sulfosuccinate; alkylbenzene sulfonates such as sodium tetradecylbenzenesulfonate, triethanolamine tetradecylbenzenesulfonate; alkylnaphthalene sulfonates; alkane sulfonates; α-sulfo fatty acid methyl ester salts; acyl isethionates; alkyl glycidyl ether sulfonates; alkyl sulfacetates; alkyl ether phosphate ester salts such as sodium lauryl phosphate, disodium lauryl phosphate, trisodium lauryl phosphate, sodium monooleyl phosphate; alkyl phosphate ester salts such as potassium lauryl phosphate; sodium caseinate; alkylaryl ether phosphates; fatty acid amide ether phosphates; phospholipids such as phosphatidylglycerol, phosphatidylinositol, phosphatidic acid, cyclic lysophosphatidic acid or its salts; silicone-based anionic surfactants such as carboxylic acid-modified silicone, phosphate-modified silicone, sulfate-modified silicone, etc.; In the case of nonionic surfactants, various polyoxyethylene addition number of polyoxyethylene alkyl ethers such as laures (polyoxyethylene lauryl ether) types, cetes (polyoxyethylene cetyl ether) types, steares (polyoxyethylene stearyl ether) types, behenes (polyoxyethylene behenyl ether), isosteares (polyoxyethylene isostearyl ether) types, octyldeces (polyoxyethylene octyldodecyl ether) types; polyoxyethylene alkyl phenyl ether; polyoxyethylene hydrogenated castor oil, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, polyoxyethylene hydrogenated castor oil monopyroglutamic acid monoisostearic acid diester, polyoxyethylene hydrogenated castor oil maleic acid and other castor oil and hydrogenated castor oil derivatives; polyoxyethylene phytosterol; polyoxyethylene cholesterol; polyoxyethylene cholestanol; polyoxyethylene lanolin; polyoxyethylene reduced lanolin;Polyoxyethylene-polyoxypropylene cetyl ether, polyoxyethylene-polyoxypropylene 2-decyltetradecyl ether, polyoxyethylene-polyoxypropylene monobutyl ether, polyoxyethylene-polyoxypropylene hydrogenated lanolin, polyoxyethylene-polyoxypropylene glycerin ether and other polyoxyethylene-polyoxypropylene alkyl ethers; polyoxyethylene-polyoxypropylene glycol; (poly)glycerin polyoxypropylene glycol such as PPG-9 diglyceryl; glycerin fatty acid partial esters such as glyceryl stearate, glyceryl isostearate, glyceryl palmitate, glyceryl myristate, glyceryl oleate, glyceryl coconut oil fatty acid, glyceryl mono-cottonseed oil fatty acid, glyceryl mono-elaidic acid, glyceryl sesquioleate, glyceryl α,α'-oleic acid pyroglutamate, glyceryl monostearate malate; polyglyceryl fatty acid esters such as polyglyceryl-2 stearate, polyglyceryl-3 stearate, polyglyceryl-4 stearate, polyglyceryl-5 stearate, polyglyceryl-6 stearate, polyglyceryl-8 stearate, polyglyceryl-10 stearate, polyglyceryl-6 distearate, polyglyceryl-10 distearate, polyglyceryl-2 tristearate, polyglyceryl-10 decastearate, polyglyceryl-2 isostearate, polyglyceryl-3 isostearate, polyglyceryl-4 isostearate, polyglyceryl-5 isostearate, polyglyceryl-6 isostearate, polyglyceryl-8 isostearate, polyglyceryl-10 isostearate, polyglyceryl-2 diisostearate (diglyceryl diisostearate), polyglyceryl-3 diisostearate, polyglyceryl-10 diisostearate, polyglyceryl-2 triisostearate, polyglyceryl-2 tetraisostearate, polyglyceryl-10 decaisostearate, polyglyceryl-2 oleate, polyglyceryl-3 oleate, polyglyceryl-4 oleate, polyglyceryl-5 oleate, polyglyceryl-6 oleate, polyglyceryl-8 oleate, polyglyceryl-10 oleate, polyglyceryl-6 dioleate, polyglyceryl-2 trioleate, polyglyceryl-10 decaoleate; ethylene glycol monofatty acid esters such as ethylene glycol monostearate; propylene glycol monofatty acid esters such as propylene glycol monostearate; pentaerythritol partial fatty acid esters; sorbitol partial fatty acid esters; maltitol partial fatty acid esters; maltitol ether;Sorbitan fatty acid esters such as sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, diglycerol sorbitan penta-2-ethylhexanoate, diglycerol sorbitan tetra-2-ethylhexanoate; sucrose fatty acid esters such as sucrose laurate, sucrose myristate, sucrose palmitate, sucrose dilaurate, sucrose dimyristate, sucrose dipalmitate, sugar derivative partial esters such as methyl glucoside fatty acid ester, trehalose undecylenate; alkyl glucosides such as caprylyl glucoside; alkyl polyglycosides; glycolipids such as mannosylerythritol lipid; lanolin alcohol; reduced lanolin; polyoxyethylene fatty acid mono- and diesters such as polyoxyethylene distearate, polyethylene glycol diisostearate, polyoxyethylene monooleate, polyoxyethylene dioleate; polyoxyethylene-propylene glycol fatty acid ester; polyoxyethylene glycerol fatty acid esters such as polyoxyethylene glycerol monostearate, polyoxyethylene glycerol monoisostearate, polyoxyethylene glycerol triisostearate; polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan tetraoleate; polyoxyethylene sorbitol fatty acid esters such as polyoxyethylene sorbitol monolaurate, polyoxyethylene sorbitol monooleate, polyoxyethylene sorbitol pentaoleate, polyoxyethylene sorbitol monostearate; polyoxyethylene methyl glucoside fatty acid ester; polyoxyethylene alkyl ether fatty acid ester; polyoxyethylene animal and vegetable oils and fats such as polyoxyethylene sorbitol beeswax; alkyl glyceryl ethers such as isostearyl glyceryl ether, chimyl alcohol, ceralkyl alcohol, batyl alcohol; polyhydric alcohol alkyl ethers;Polyoxyethylene alkylamine; tetra-polyoxyethylene·tetra-polyoxypropylene-ethylenediamine condensates; natural surfactants such as saponin, surfactin, rhamnolipid, sophorolipid; polyoxyethylene fatty acid amide; fatty alkanolamides such as coconut fatty acid monoethanolamide (cocamide MEA), coconut fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (paltamide MEA), palmitic acid diethanolamide (paltamide DEA), coconut fatty acid methylethanolamide (cocamide methyl MEA); alkyl dimethylamine oxides such as lauramine oxide, cocamine oxide, stearamine oxide, behenamine oxide; alkyl ethoxydimethylamine oxide; polyoxyethylene alkyl mercaptan; silicone-based nonionic surfactants such as polyether-modified silicone like dimethicone copolyol, polysiloxane·oxyalkylene copolymer, polyglycerin-modified silicone, sugar-modified silicone, etc.; for cationic surfactants, alkyl trimethyl ammonium chlorides such as behentrimonium chloride, stearyltrimonium chloride, cetrimonium chloride, lauryltrimonium chloride; alkyl trimethyl ammonium bromides such as stearyltrimonium bromide; dialkyl dimethyl ammonium chlorides such as distearyldimonium chloride, dicocodimonium chloride; fatty amide amines and their salts such as stearamide propyldimethylamine, stearamide ethyldiethylamine; alkyl ether amines and their salts or quaternary salts such as stearoxypropyldimethylamine; fatty amide type quaternary ammonium salts such as long-chain branched fatty acid (12 - 31) aminopropyl ethyldimethyl ammonium ethyl sulfate, lanolin fatty acid aminopropyl ethyldimethyl ammonium ethyl sulfate; polyoxyethylene alkylamine and its salts or quaternary salts; alkylamine salts; fatty amide guanidinium salts; alkyl ether amine monium salts; alkyl trialkylene glycol ammonium salts; benzalkonium salts;Benzethonium salts; pyridinium salts such as cetylpyridinium chloride; imidazolinium salts; alkylisoquinolinium salts; dialkylmorphonium salts; polyamine fatty acid derivatives; amino-modified silicones such as aminopropyldimethylsilicone and amodimethicone, cation-modified silicones, cation-modified and polyether-modified silicones, amino-modified and polyether-modified silicones, and other silicone-based cationic surfactants; for amphoteric surfactants, N-alkyl-N,N-dimethylamino acid betaines such as lauryl betaine (lauryldimethylaminoacetic acid betaine); fatty acid amide alkyl-N,N-dimethylamino acid betaines such as cocamidopropyl betaine and lauramidopropyl betaine; imidazoline-type betaines such as sodium cocoamphoacetate and sodium lauroamphoacetate; alkylsulfobetaines such as alkyldimethyltaurine; sulfate-type betaines such as alkyldimethylaminoethanol sulfate ester; phosphate-type betaines such as alkyldimethylaminoethanol phosphate ester; sphingolipids such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, sphingomyelin; phospholipids such as lysophosphatidylcholine, hydrogenated soybean phospholipid, partially hydrogenated soybean phospholipid, hydrogenated egg yolk phospholipid, partially hydrogenated egg yolk phospholipid, hydroxylated lecithin; silicone-based amphoteric surfactants; for polymer surfactants, polyvinyl alcohol, sodium alginate, starch derivatives, tragacanth gum, acrylic acid·methacrylic acid alkyl copolymers; various silicone-based surfactants are preferably mentioned.

[0035] Examples of polymers, thickeners, and gelling agents include guar gum, locust bean gum, carob seed, carrageenan, galactan, gum arabic, tara gum, tamarind, farselan, karaya gum, velvetleaf, carrageenan, tragacanth gum, pectin, pectic acid and salts such as sodium salts, alginic acid and salts such as sodium salts, mannan; starches such as rice, corn, potato, and wheat; xanthan gum, dextran, succinoglucan, curdlan, hyaluronic acid and its salts, xanthan gum, pullulan, gellan gum, chitin, chitosan, agar, cassou extract, chondroitin sulfate, casein, collagen, gelatin, albumin; methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose and salts such as its sodium salt, methyl hydroxypropyl cellulose, carboxylated cellulose nanofiber, carboxymethylated cellulose nanofiber, phosphoric acid esterified cellulose nanofiber, sulfonated cellulose nanofiber, sodium cellulose sulfate, dialkyldimethylammonium sulfate cellulose, crystalline cellulose, cellulose powder and other celluloses and their derivatives; soluble starch, carboxymethyl starch, methyl hydroxypropyl starch, methyl starch and other starch-based polymers, starch derivatives such as hydroxypropyltrimonium chloride starch, octenyl succinic acid corn starch aluminum; alginic acid derivatives such as sodium alginate, propylene glycol alginate; polyvinyl pyridone (PVP), polyvinyl alcohol (PVA), vinyl pyridone-vinyl alcohol copolymer, polyvinyl methyl ether; polyethylene glycol, polypropylene glycol, polyoxyethylene-polyoxypropylene copolymer; amphoteric methacrylic acid ester copolymers such as (methacryloyloxyethyl carboxybetaine / methacrylic acid alkyl) copolymer, (acrylates / stearyl acrylate / ethylamine oxide methacrylate) copolymer; (dimethyl silicone / vinyl dimethyl silicone) cross-polymer, (alkyl acrylate / diacetone acrylamide) copolymer, (alkyl acrylate / diacetone acrylamide) copolymer AMP;Partially saponified polyvinyl acetate, maleic acid copolymer; vinylpyrrolidone-dialkylaminoalkyl methacrylate copolymer; acrylic resin alkanolamine; polyester, water-dispersible polyester; polyacrylamide; polyacrylate ester copolymer such as polyethyl acrylate, carboxyvinyl polymer, polyacrylic acid and its salts such as sodium salt, acrylic acid-methacrylic acid ester copolymer; acrylic acid-alkyl methacrylate copolymer; cationized cellulose such as polyquaternium-10, diallyldimethylammonium chloride-acrylamide copolymer such as polyquaternium-7, acrylic acid-diallyldimethylammonium chloride copolymer such as polyquaternium-22, acrylic acid-diallyldimethylammonium chloride-acrylamide copolymer such as polyquaternium-39, acrylic acid-cationized methacrylate ester copolymer, acrylic acid-cationized methacrylamide copolymer, acrylic acid-methyl acrylate-methacrylamidopropyltrimethylammonium chloride copolymer such as polyquaternium-47, choline methacrylate chloride polymer; cationized oligosaccharide, cationized dextran, cationized polysaccharide such as guar hydroxypropyltrimonium chloride; polyethyleneimine; cationic polymer; polymer of 2-methacryloyloxyethyl phosphorylcholine such as polyquaternium-51 and copolymer with butyl methacrylate etc.; acrylic resin emulsion, polyethyl acrylate emulsion, polyalkyl acrylate emulsion, polyvinyl acetate resin emulsion, natural rubber latex, synthetic latex and other polymer emulsions; nitrocellulose; polyurethanes and various copolymers; various silicones; various silicone copolymers such as acrylic-silicone graft copolymer; various fluorine-based polymers; 12-hydroxystearic acid and its salts; dextrin fatty acid esters such as dextrin palmitate, dextrin myristate;Anhydrous silicic acid, fumed silica (ultrafine anhydrous silicic acid), magnesium aluminum silicate, magnesium sodium silicate, metal soap, metal dialkyl phosphate, bentonite, hectorite, organically modified clay minerals, sucrose fatty acid ester, and fructooligosaccharide fatty acid ester are preferably mentioned.;

[0036] Examples of the antioxidant include tocopherol (vitamin E), tocopherol derivatives such as tocopheryl acetate; BHT, BHA; gallic acid derivatives such as propyl gallate; vitamin C (ascorbic acid) and / or its derivatives; erythorbic acid and its derivatives; sulfites such as sodium sulfite; bisulfites such as sodium bisulfite; thiosulfates such as sodium thiosulfate; metabisulfites; thiotaurine, hypotaurine; thioglycerol, thiourea, thioglycolic acid, cysteine hydrochloride. Examples of the reducing agent include thioglycolic acid, cysteine, cysteamine and the like. Examples of the oxidizing agent include hydrogen peroxide solution, ammonium persulfate, sodium bromate, percarbonate and the like. Examples of the antioxidant include ascorbic acid phosphate ester salts such as ascorbic acid, sodium ascorbic acid phosphate ester and magnesium ascorbic acid phosphate ester; ascorbic acid fatty acid esters such as ascorbic acid monostearate, ascorbic acid monopalmitate, ascorbic acid dipalmitate, ascorbic acid tetraisopalmitate; ascorbic acid ethers such as 3-O-ethylascorbic acid, 2-O-ethylascorbic acid, cetyl ascorbic acid, glyceryl ascorbic acid, hexyl glyceryl ascorbic acid; ascorbic acid glucosides such as ascorbic acid-2-glucoside and its fatty acid esters; ascorbic acid derivatives such as ascorbic acid sulfate ester, tocopheryl ascorbyl phosphate; vitamin A compounds such as retinol, retinol acetate, retinol palmitate, hydrogenated retinol; vitamin E compounds such as tocopherol, tocopheryl acetate, tocotrienol; carotenoids such as carotene, lycopene, astaxanthin, lutein; polyphenols such as phlorotannin, curcumin, anthocyanin, proanthocyanidin, catechin, ellagic acid, quercetin, apple polyphenol; coenzyme Q10, lipoic acid, lactoferrin, sesamin, hesperidin, proanthocyanidin, lignan, chlorogenic acid, rutin, fullerene, platinum nanocolloid and the like.

[0037] Examples of skin-whitening agents include hydroquinone glycosides such as arbutin and α-arbutin and their esters; ascorbic acid phosphate ester salts such as ascorbic acid, sodium ascorbic acid phosphate ester, and magnesium ascorbic acid phosphate ester; ascorbic acid fatty acid esters such as ascorbic acid monostearate, ascorbic acid monopalmitate, ascorbic acid dipalmitate, and ascorbic acid tetraisopalmitate; ascorbic acid ethers such as 3-O-ethyl ascorbic acid, 2-O-ethyl ascorbic acid, cetyl ascorbic acid, glyceryl ascorbic acid, and hexyl glyceryl ascorbic acid; ascorbic acid glucosides such as ascorbic acid-2-glucoside and their fatty acid esters; ascorbic acid derivatives such as ascorbic acid sulfate ester and tocopheryl ascorbyl phosphate; tranexamic acid derivatives such as tranexamic acid, cetyl tranexamic acid, and tranexamic acid amide; licorice extract-related substances such as glabridin, glabrene, liquiritin, and isoliquiritin; plant extracts such as kojic acid, ellagic acid, ferulic acid and its derivatives, placenta extract, glutathione, oryzanol, butylresorcinol, oil-soluble chamomile extract, oil-soluble licorice extract, tamarix chinensis extract, and saxifraga stolonifera extract are preferably mentioned.

[0038] Examples of vitamins and their derivatives include vitamin A such as retinol, retinol acetate, retinol palmitate; vitamin B group such as thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, pyridoxine dipalmitate, flavin adenine dinucleotide, cyanocobalamin, folic acids, nicotinic acids such as nicotinamide, benzyl nicotinate, cholines; vitamin C such as ascorbic acid and its salts such as sodium ascorbate; vitamin D; vitamin E such as α, β, γ, δ-tocopherol; other vitamins such as pantothenic acid, biotin; ascorbic acid phosphate salts such as sodium ascorbic acid phosphate ester salt and magnesium ascorbic acid phosphate ester salt, ascorbic acid fatty acid esters such as ascorbic acid tetraisopalmitate, stearyl ascorbate, palmitoyl ascorbate, dipalmitoyl ascorbate, ascorbic acid alkyl ethers such as ascorbic acid ethyl ether, ascorbic acid glucosides such as ascorbic acid-2-glucoside and its fatty acid esters, ascorbic acid derivatives such as ascorbyl phosphate tocopherol; vitamin derivatives such as tocopherol derivatives such as nicotinic acid tocopherol, tocopherol acetate, tocopherol linoleate, tocopherol ferulate, tocopherol phosphate ester, tocotrienol, and other various vitamin derivatives are preferably mentioned.

[0039] Examples of plant, animal, and microbial extracts include iris extract, ashitaba extract, asunaro extract, asparagus extract, avocado extract, amacha extract, almond extract, hollyhock extract, arnica extract, aloe extract, apricot extract, apricot kernel extract, ginkgo extract, licorice extract, wikyo extract, turmeric extract, oolong tea extract, Japanese lacquer extract, eiju extract, etinashi leaf extract, enmei mushroom extract, gold extract, oubaku extract, uren extract, barley extract, otane carrot extract, viola extract, odoricoso extract, ononis extract, Dutch horseradish extract, orange extract, dried seafood, seaweed extract, oyster leaf extract, kakiok extract, hydrolyzed elastin, hydrolyzed wheat flour, hydrolyzed silk, kakkon extract, chamomile extract, oil-soluble chamomile extract, carrot extract, kawarayomogi extract, karasumugi extract, calcade extract, kanso extract, oil-soluble kanso extract, kiwi extract, kio extract, shiitake mushroom extract, quinine extract, cucumber extract, oak leaf extract, guanosine, guava extract, kujin extract, gardenia extract, kuma sasae extract, clara extract, walnut extract, chestnut extract, grapefruit extract, clematis extract, black rice extract, black sugar extract, black vinegar extract, chlorella extract, kuwa extract, gentiana extract, genno shoko extract, black tea extract, yeast extract, koboaku extract, coffee extract, burdock extract, rice extract, fermented rice extract, rice bran fermented extract, rice germ oil, comfrey extract, collagen, kokemomo extract, saicin extract, saiko extract, saibai extract, saffron extract, salvia extract, soapwort extract, sasae extract, Japanese medlar extract, sansha extract, sansho extract, shiitake mushroom extract, dio extract, shikon extract, perilla extract, sinano oak extract, shimotsuke so extract, jatoba extract, peony extract, shokyu extract, shobu root extract, shirakaba extract, white shiitake mushroom extract, sugina extract, stevia extract, fermented stevia, tamarix chinensis extract, European ivy extract, European medlar extract, European pansy extract, European mint extract, sage extract, zeniaoi extract, senkyu extract, senburi extract, sohakuhi extract, daiou extractExtracts such as soybean extract, spinach extract, thyme extract, dandelion extract, lichen extract, tea extract, clove extract, chigaya extract, chinpi extract, tea tree oil, sweet tea extract, capsicum extract, toki extract, toki nsenka extract, tou'nin extract, thuja extract, dokudami extract, tomato extract, natto extract, carrot extract, garlic extract, rosa multiflora extract, hibiscus extract, buckmoundou extract, lotus extract, parsley extract, birch extract, honey, witch hazel extract, Parietaria extract, hikiokoshi extract, bisabolol, hinoki extract, bifidobacterium extract, loquat extract, fuki dandelion extract, fuki notou extract, bukuryou extract, butcher's bloom extract, grape extract, grape seed extract, propolis, loofah extract, safflower extract, peppermint extract, bodaiju extract, button extract, hop extract, mykaika extract, pine extract, maronier extract, mizubashou extract, mulberry extract, Melissa extract, mozuku extract, peach extract, yaguruma giku extract, eucalyptus extract, snowdrop extract, yuzu extract, lily extract, yokuin'nin extract, mugwort extract, lavender extract, green tea extract, eggshell membrane extract, apple extract, rooibos tea extract, raisin extract, lettuce extract, lemon extract, rengyou extract, renge sou extract, rose extract, rosemary extract, roman chamomile extract, royal jelly extract, waremokou extract, etc. are preferably listed as such.

[0040] Examples of ultraviolet absorbers include benzoic acid - based ultraviolet absorbers such as para - aminobenzoic acid, monoglycerin ester of para - aminobenzoic acid, ethyl N,N - dipropoxy para - aminobenzoate, ethyl N,N - diethoxy para - aminobenzoate, ethyl N,N - dimethyl para - aminobenzoate, butyl N,N - dimethyl para - aminobenzoate, ethyl N,N - dimethyl para - aminobenzoate; anthranilic acid - based ultraviolet absorbers such as homomenthyl - N - acetylanthranilate; salicylic acid and its sodium salt, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p - isopropanolphenyl salicylate and other salicylic acid - based ultraviolet absorbers; cinnamic acid - based ultraviolet absorbers such as octyl cinnamate, ethyl - 4 - isopropyl cinnamate, methyl - 2,5 - diisopropyl cinnamate, ethyl - 2,4 - diisopropyl cinnamate, methyl - 2,4 - diisopropyl cinnamate, propyl - p - methoxy cinnamate, isopropyl - p - methoxy cinnamate, isoamyl - p - methoxy cinnamate, 2 - ethylhexyl p - methoxy cinnamate (octyl paramethoxycinnamate), 2 - ethoxyethyl - p - methoxy cinnamate (sinoxate), cyclohexyl - p - methoxy cinnamate, ethyl - α - cyano - β - phenyl cinnamate, 2 - ethylhexyl α - cyano - β - phenyl cinnamate (octocrylene), glyceryl mono - 2 - ethylhexanoyl - diparamethoxy cinnamate, ferulic acid and its derivatives;Benzophenone-based ultraviolet absorbers such as 2,4-dihydroxybenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone, 2,2',4,4'-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone (oxybenzone-3), 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4'-phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone; 3-(4'-methylbenzylidene)-d,l-camphor, 3-benzylidene-d,l-camphor; 2-phenyl-5-methylbenzoxazole; 2,2'-hydroxy-5-methylphenylbenzotriazole; 2-(2'-hydroxy-5'-t-octylphenyl)benzotriazole; 2-(2'-hydroxy-5'-methylphenylbenzotriazole; dibenzalazine; dianisoylmethane; 5-(3,3-dimethyl-2-norbornylidene)-3-pentan-2-one; dibenzoylmethane derivatives such as 4-t-butylmethoxydibenzoylmethane; octyltriazone; urocanic acid derivatives such as urocanic acid and ethyl urocanate; 2-(2'-hydroxy-5'-methylphenyl)benzotriazole, 1-(3,4-dimethoxyphenyl)-4,4-dimethyl-1,3-pentanedione, hydantoin derivatives such as 2-ethylhexyl dimethoxybenzylidene dioxoimidazolidine propionate, phenylbenzimidazolesulfonic acid, terephthalylidene dicamphor sulfonic acid, droxmetrizole trisiloxane, methyl anthranilate, rutin and its derivatives, oryzanol and its derivatives are preferably mentioned.;

[0041] Examples of antibacterial and preservative agents include parabens (hydroxybenzoic acid esters) such as methylparaben, ethylparaben, propylparaben, and butylparaben; phenoxyethanol; 1,2-alkanediols such as 1,2-pentanediol, 1,2-hexanediol, and 1,2-octanediol; alkyl glyceryl ethers such as 2-ethylhexyl glyceryl ether (ethylhexyl glycerin); salicylic acid; lanolin fatty acids and their salts; sodium benzoate; isothiazolinone derivatives such as methylchloroisothiazolinone and methylisothiazolinone; imidazolinium urea; dehydroacetic acid and its salts; phenols; halogenated bisphenols such as triclosan, acid amides, quaternary ammonium salts; trichlorocarbanide, zinc pyrithione, benzalkonium chloride, benzethonium chloride, sorbic acid, chlorhexidine, chlorhexidine gluconate, halocarban, hexachlorophene, hinokitiol; other phenols such as phenol, isopropylphenol, cresol, thymol, parachlorophenol, phenylphenol, and sodium phenylphenol; phenylethyl alcohol, photosensitizers, antibacterial zeolites, and silver ions. However, when used as an antibacterial or preservative agent for the purpose of preservation, from the perspective of the safety of cosmetics or topical skin preparations, it is more preferable to use phenoxyethanol; 1,2-alkanediols such as 1,2-pentanediol, 1,2-hexanediol, and 1,2-octanediol; and alkyl glyceryl ethers such as 2-ethylhexyl glyceryl ether.

[0042] Chelating agents include preferably edetates such as EDTA, EDTA2Na, EDTA3Na, EDTA4Na (ethylenediaminetetraacetate); hydroxyethylethylenediaminetriacetates such as HEDTA3Na; pentetates (diethylenetriaminepentaacetate); phytic acid; phosphonic acids such as etidronic acid and salts thereof such as sodium salts; sodium oxalate; polyamino acids such as polyaspartic acid and polyglutamic acid; sodium polyphosphate, sodium metaphosphate, phosphoric acid; sodium citrate, citric acid, alanine, dihydroxyethylglycine, gluconic acid, ascorbic acid, succinic acid, tartaric acid.

[0043] pH adjusters, acids, and alkalis include preferably citric acid, sodium citrate, lactic acid, sodium lactate, glycolic acid, succinic acid, acetic acid, sodium acetate, malic acid, tartaric acid, fumaric acid, phosphoric acid, hydrochloric acid, sulfuric acid, monoethanolamine, diethanolamine, triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propanediol, arginine, sodium hydroxide, potassium hydroxide, aqueous ammonia, guanidine carbonate, ammonium carbonate.

[0044] As solvents and propellants, lower alcohols such as ethanol, 2-propanol (isopropyl alcohol), butanol, isobutyl alcohol; glycols such as propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol, isopentyl diol; glycol ethers such as diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, triethylene glycol monoethyl ether, diethylene glycol diethyl ether, diethylene glycol dibutyl ether, propylene glycol monoethyl ether, dipropylene glycol monoethyl ether; glycol ether esters such as ethylene glycol monoethyl ether acetate, diethylene glycol monoethyl ether acetate, propylene glycol monoethyl ether acetate; glycol esters such as diethoxyethyl succinate, ethylene glycol disuccinate; benzyl alcohol, benzyloxyethanol, propylene carbonate, dialkyl carbonate, acetone, ethyl acetate, N-methylpyrrolidone; toluene; fluorocarbons, next-generation chlorofluorocarbons; propellants such as LPG, dimethyl ether, carbon dioxide gas are preferably mentioned.

[0045] Examples of antipruritics include diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, substance-P inhibitors, etc. Examples of keratolytic and resolvent agents include salicylic acid, sulfur, resorcinol, selenium sulfide, pyridoxine, glycolic acid, etc. Examples of antiperspirants include hydroxyaluminum chloride, aluminum chloride, zinc oxide, zinc paraphenolsulfonate, etc. Examples of cooling agents include menthol, methyl salicylate, etc. Examples of astringents include citric acid, tartaric acid, lactic acid, aluminum potassium sulfate, tannic acid, caffeine, etc. Examples of enzymes include superoxide dismutase, catalase, lysozyme chloride, lipase, papain, pancreatin, protease, etc. Preferred examples of nucleic acids include ribonucleic acid and its salts, deoxyribonucleic acid and its salts, and disodium adenosine triphosphate.

[0046] As anti-inflammatory agents, glycyrrhizic acid and its derivatives, glycyrrhetinic acid derivatives, salicylic acid and its derivatives, azelaic acid and its derivatives, hinokitiol, guaiazulene, allantoin, indomethacin, zinc oxide, hydrocortisone acetate, prednisone, diphenhydramine hydrochloride, chlorpheniramine maleate; plant extracts such as peach leaf extract and mugwort leaf extract are preferably mentioned. As hair growth agents, blood circulation promoters, and stimulants, plant extracts and tinctures such as centella extract, capsicum tincture, ginger tincture, ginger extract, cantharis tincture; capsaicin, nonivamide, zingerone, ichthyol, tannic acid, borneol, cyclandelate, cinnarizine, tolazoline, acetylcholine, verapamil, cephalanthin, γ-oryzanol, cephalanthin, derivatives such as vitamin E and tocopheryl nicotinate·tocopheryl acetate, γ-oryzanol, nicotinic acid and derivatives such as nicotinamide·benzyl nicotinate·inositol hexanicotinate, nicotinyl alcohol, allantoin, photosensitizer 301, photosensitizer 401, capronium chloride, monoglyceride pentadecanoate, flavanonol derivatives, stigmasterol or stigmastanol and its glycosides, minoxidil are preferably mentioned. As hormones, estradiol, estrone, ethinyl estradiol, cortisone, hydrocortisone, prednisone, etc. are preferably mentioned.

[0047] Examples of anti-wrinkle and anti-aging agents include ascorbic acid phosphate salts such as ascorbic acid, sodium ascorbic acid phosphate ester, and magnesium ascorbic acid phosphate ester; ascorbic acid fatty acid esters such as ascorbic acid monostearate, ascorbic acid monopalmitate, ascorbic acid dipalmitate, and ascorbic acid tetraisopalmitate; ascorbic acid ethers such as 3-O-ethylascorbic acid, 2-O-ethylascorbic acid, cetyl ascorbic acid, glyceryl ascorbic acid, and hexyl glyceryl ascorbic acid; ascorbic acid glucosides such as ascorbic acid-2-glucoside and their fatty acid esters; ascorbic acid derivatives such as ascorbic acid sulfate ester and tocopheryl ascorbyl phosphate; vitamin A compounds such as retinol, retinol acetate, retinol palmitate, and hydrogenated retinol; nicotinamide, glutathione, cysteine, crocin, sericin, geraniol, glycerin glucoside, lactoferrin, proanthocyanidin, pantothenic acid, panthenol, soybean saponin, levesterol, isoflavone, coenzyme Q10, chondroitin sulfate, N-acetylglucosamine, glycerophosphatidylcholine, hydrolyzed hyaluronic acid, collagen peptide, conchiolin hydrolyzate, adenosine 5'-phosphate, phosphatidylinositol, isopropyl oxopropylamino carbonyl pyrrolidine carbonyl methyl propylamino carbonyl benzoyl amino acetic acid Na, tranexamic acid and its derivatives, etc. are preferably mentioned.

[0048] Preferred examples of the soothing agent include mannosylerythritol lipid, diethylene glycol oligomer diester of dimer linoleic acid, diisostearyl malate, N-acyl-L-glutamic acid, trehalose monofatty acid ester, fatty acid amide amine oxide, alkyldimethylamine oxide, phenylethyl glucoside, lauryl glucoside, ferulic acid glucoside, salicin, cedrol, polyethylene glycol, polypropylene glycol and the like. Preferred examples of the cooling agent include menthol, camphor, menthyl lactate, monomethyl succinate, menthyl acetate, borneol, cineole, thymol, peppermint oil, mint oil and derivatives thereof. Preferred examples of the warming agent include vanillin and its derivatives, vanillyl amide of nonanoic acid, gingerol, zingerone, capsicum tincture, capsicum extract, benzyl nicotinate, methyl nicotinate, phenyl nicotinate, nicotinic acid derivatives such as tocopherol nicotinate, capsaicin, Dutch pepper extract, sansho extract, ginger extract, cantharides extract and the like.

[0049] Examples of powders include mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, muscovite, phlogopite, synthetic mica, red mica, biotite, vermiculite, magnesium carbonate, calcium carbonate, aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, metal tungstates, magnesium, zeolite, barium sulfate, calcined calcium sulfate, calcium phosphate, fluorapatite, hydroxyapatite, ceramic powder, bentonite, smectite, clay, mud, metal soaps (e.g., zinc myristate, calcium palmitate, aluminum stearate), calcium carbonate, red iron oxide, yellow iron oxide, black iron oxide, ultramarine, navy blue, carbon black, titanium oxide, particulate and ultrafine particulate titanium oxide, zinc oxide, particulate and ultrafine particulate zinc oxide, alumina, silica, fumed silica (ultrafine anhydrous silicic acid), mica titanium, fish scale foil, boron nitride, photochromic pigments, synthetic fluorophlogopite, particulate composite powders, gold, aluminum, and other inorganic powders of various sizes and shapes, and inorganic powders such as those obtained by treating these with various surface treatment agents such as hydrogen silicone, cyclic hydrogen silicone, or other silanes or titanium coupling agents to render them hydrophobic or hydrophilic; organic powders and surface-treated powders, and organic-inorganic composite powders of various sizes and shapes such as starch, cellulose, nylon powder, polyethylene powder, polymethyl methacrylate powder, polystyrene powder, copolymer resin powder of styrene and acrylic acid, polyester powder, benzoguanamine resin powder, laminated powder of polyethylene terephthalate and polymethyl methacrylate, laminated powder of polyethylene terephthalate, aluminum, and epoxy, etc., urethane powder, silicone powder, Teflon (registered trademark) powder, etc. are preferred.Examples of inorganic salts include sodium chloride-containing salts such as table salt, refined salt, rock salt, sea salt, and natural salt; potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, bittern, zinc chloride, ammonium chloride; sodium sulfate, aluminum sulfate, aluminum potassium sulfate (alum), aluminum ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate, zinc sulfate, iron sulfate, copper sulfate; sodium phosphates such as monosodium phosphate, disodium phosphate, trisodium phosphate, potassium phosphates, calcium phosphates, and magnesium phosphates are preferably mentioned.

[0050] As pigments, colorants, dyes, and pigments, there are legal pigments such as Brown No. 201, Black No. 401, Purple No. 201, Purple No. 401, Blue No. 1, Blue No. 2, Blue No. 201, Blue No. 202, Blue No. 203, Blue No. 204, Blue No. 205, Blue No. 403, Blue No. 404, Green No. 3, Green No. 201, Green No. 202, Green No. 204, Green No. 205, Green No. 3, Green No. 401, Green No. 402, Red No. 102, Red No. 104-1, Red No. 105-1, Red No. 106, Red No. 2, Red No. 3, Red No. 201, Red No. 202, Red No. 203, Red No. 204, Red No. 205, Red No. 206, Red No. 207, Red No. 208, Red No. 213, Red No. 214, Red No. 215, Red No. 218, Red No. 219, Red No. 220, Red No. 221, Red No. 223, Red No. 225, Red No. 226, Red No. 227, Red No. 228, Red No. 230-1, Red No. 230-2, Red No. 231, Red No. 232, Red No. 3, Red No. 401, Red No. 404, Red No. 405, Red No. 501, Red No. 502, Red No. 503, Red No. 504, Red No. 505, Red No. 506, Orange No. 201, Orange No. 203, Orange No. 204, Orange No. 205, Orange No. 206, Orange No. 207, Orange No. 401, Orange No. 402, Orange No. 403, Yellow No. 201, Yellow No. 202-1, Yellow No. 202-2, Yellow No. 203, Yellow No. 204, Yellow No. 205, Yellow No. 4, Yellow No. 401, Yellow No. 402, Yellow No. 403-1, Yellow No. 404, Yellow No. 405, Yellow No. 406, Yellow No. 407, Yellow No. 5, etc.; other acid dyes such as Acid Red 14; basic dyes such as Arianor Sienna Brown, Arianor Madder Red, Arianor Steel Blue, Arianor Straw Yellow, etc.; nitro dyes such as HC Yellow 2, HC Yellow 5, HC Red 3, 4-hydoxypropylamino-3-nitrophenol, N,N’-bis(2-hydroxyethyl)-2-nitro-p-phenylenediamine, HC Blue 2, Basic Blue 26, etc.; disperse dyes; inorganic white pigments such as titanium dioxide, zinc oxide, etc.; inorganic red pigments such as iron oxide (red iron oxide), iron titanate, etc.; inorganic brown pigments such as γ-iron oxide, etc.; inorganic yellow pigments such as yellow iron oxide, loess, etc.; inorganic black pigments such as black iron oxide, lower-order titanium oxide, etc.Inorganic purple pigments such as mango violet and cobalt violet; inorganic green pigments such as chromium oxide, chromium hydroxide, and cobalt titanate; inorganic blue pigments such as ultramarine and navy blue; pearl pigments such as titanium oxide-coated mica, titanium oxide-coated bismuth oxychloride, titanium oxide-coated talc, colored titanium oxide-coated mica, bismuth oxychloride, and fish scale foil; metal powder pigments such as aluminum powder, copper powder, and gold; anthraquinones such as astaxanthin and alizarin, anthocyanidins, β-carotene, catenares, capsanthin, chalcones, carthamin, quercetin, crocin, chlorophyll, curcumin, cochineal, and shikonin, naphthoquinones such as bixin, flavones, betacyanidin, henna, hemoglobin, lycopene, riboflavin, and rutin, natural pigments and dyes; oxidation dye intermediates and couplers such as p-phenylenediamine, toluene-2,5-diamine, o-, m-, or p-aminophenol, m-phenylenediamine, 5-amino-2-methylphenol, resorcinol, 1-naphthol, 2,6-diaminopyridine, and their salts; auto-oxidation type dyes such as indoline; dihydroxyacetone is preferably mentioned.;

[0051] As spices, there are acetyl cedrene, amyl cinnamaldehyde, allyl amyl glycolate, β-ionone, isoeugenol, isobutyl quinoline, iris oil, iron, indole, ylang-ylang oil, undecanal, undecenal, γ-undecalactone, estragole, eugenol, oakmoss, opoponax resinoid, orange oil, eugenol, aurantiol, galaxolide, carvacrol, L-carboxylic, camphor, canon, carrot seed oil, clove oil, methyl caffeate, geraniol, geranyl nitrile, isobornyl acetate, geranyl acetate, dimethyl benzyl carbinyl acetate, styrallyl acetate, cedryl acetate, terpinyl acetate, p-t-butyl cyclohexyl acetate, vetiveryl acetate, benzyl acetate, linalyl acetate, isopentyl salicylate, benzyl salicylate, sandalwood oil, santalol, cyclamen aldehyde, cyclopentadecanolide, methyl dihydrojasmonate, dihydromyrcenol, jasmine absolute, jasmine lactone, cis-jasmone, citral, citronellol, citronellal, cinnamon bark oil, 1,8-cineole, cinnamaldehyde, styrax resinoid, cedarwood oil, cedrene, cedrol, celery seed oil, thyme oil, damascone, damasconene, thymol, tuberose absolute, decanal, decalactone, terpineol, γ-terpinene, triplal, nerol, nonanal, 2,6-Nonadienol, nonalactone, patchouli alcohol, vanilla absolute, vanillin, basil oil, patchouli oil, hydroxycitronellal, α-pinene, piperitone, phenethyl alcohol, phenylacetaldehyde, ptychopetalum oil, hexylcinnamaldehyde, cis-3-hexenol, peru balsam, vetiver oil, vetiverol, peppermint oil, pepper oil, heliotropin, bergamot oil, benzyl benzoate, borneol, myrrh resinoid, musk ketone, methyl nonyl acetaldehyde, γ-methyl ionone, menthol, L-menthol, L-menthone, eucalyptus oil, β-ionone, lime oil, lavender oil, D-limonene, linalool, lilial, lilyal, lemon oil, rose absolute, rose oxide, rose oil, rosemary oil, synthetic fragrances and natural fragrances such as various essential oils, and various compounded fragrances are preferably mentioned.

[0052] As water, in addition to ordinary water and purified water, hard water, soft water, natural water, deep ocean water, electrolyzed alkaline ionized water, electrolyzed acidic ionized water, ionized water, and cluster water are preferably mentioned.

[0053] In addition to these, ingredients described in cosmetic raw material standards, ingredient specifications for different types of cosmetics, the list of ingredient display names of the Japan Cosmetic Industry Association, the INCI Dictionary (The International Cosmetic Ingredient Dictionary and Handbook), raw material specifications for quasi-drugs, the Japanese Pharmacopoeia, pharmaceutical additive specifications, the Food Additive Codex, etc., and ingredients described in Japanese and foreign patent gazettes and patent published gazettes (including published gazettes and re-published gazettes) belonging to the classifications of A61K7 and A61K8 in the International Patent Classification IPC, etc., known cosmetic ingredients, pharmaceutical ingredients, food ingredients, etc. can be contained in known combinations, mixing ratios, and amounts.

[0054] Examples of the types of cosmetics of the present invention include hair cosmetics, skin cosmetics, makeup cosmetics, fragrance cosmetics, body cosmetics, etc. The cosmetics of the present invention can be manufactured according to ordinary methods.

[0055] When the types of the cosmetics of the present invention are described in more detail, as hair cosmetics, shampoos such as oil shampoo, cream shampoo, conditioning shampoo, dandruff shampoo, shampoo for hair color, integrated rinse shampoo, etc.; hair care agents such as rinse, conditioner, treatment, hair pack, leave-on treatment, hair mist, hair oil, etc.; hair styling agents such as hair foam, hair mousse, hair spray, hair wax, hair gel, hair cream, water grease, setting lotion, pomade, tic, etc.; hair dyes such as color lotion, hair color treatment, hair manicure, oxidative hair dye, etc.; hair tonic, hair liquid, hair blow, sideburn coat, permanent wave agent, straight perm agent, hair bleach, hair color pretreatment, hair color aftertreatment, perm pretreatment, perm aftertreatment, hair growth agent are preferably mentioned.

[0056] Examples of skin cosmetics include lotions such as softening lotion, astringent lotion, cleansing lotion, multi-layered lotion, liposome lotion, etc., emulsions such as emollient emulsion, moisturizing emulsion, milky lotion, nourishing lotion, nourishing milk, skin moisturizer, moisturizing emulsion, massage lotion, cutin smoother, elbow lotion, hand lotion, body lotion, etc., creams such as emollient cream, nourishing cream, nourishing cream, vanishing cream, moisturizing cream, night cream, massage cream, cleansing cream, makeup cream, base cream, pre-makeup cream, sunscreen cream, suntan cream, hair removal cream, deodorant cream, shaving cream, cutin softening cream, etc., gels such as moisturizing gel, whitening gel, all-in-one gel, etc., and skin care cosmetics such as beauty essences such as moisturizing essence, whitening essence, moisturizing serum, whitening serum, etc.; sunscreen cosmetics such as sun protect, sun protector, UV care milk, sunscreen, etc.; pack - mask products such as peel-off pack, powder pack, washing pack, oil pack, cleansing mask, etc.; cleansing cosmetics such as cleansing foam, cleansing cream, cleansing milk, cleansing lotion, cleansing gel, cleansing oil, etc.; facial cleansers such as paste facial cleansing foam, gel facial cleansing foam, foaming facial cleansing foam, facial cleansing powder, cosmetic soap, transparent soap, medicinal soap, liquid soap, beard shaving soap, etc. are preferably mentioned.

[0057] Examples of makeup cosmetics preferably include lipstick, lip gloss, foundation, blush, powder, concealer, eyeliner, mascara, eyeshadow, eyebrow pencil, eyebrow brush, nail enamel, enamel remover, nail treatment.

[0058] Examples of fragrance cosmetics preferably include perfume, perfume, parfum, eau de parfum, eau de toilette, eau de cologne, compound perfume, fragrant powder, perfume soap, body lotion, bath oil.

[0059] Examples of body cosmetics include body cleansing products such as body shampoos, deodorant lotions, deodorant powders, deodorant sprays, deodorant sticks and other anti - odor cosmetics, depigmenting agents, hair removal and hair - removing agents, bath agents, and insect repellents such as insect repellent sprays.

[0060] Examples of the types of the external skin preparations of the present invention preferably include ointments, lotions, creams or gel - like external skin preparations, patches, liniments, liquid coating agents, etc. Further, it can also be used as oral cosmetics such as toothpaste and mouthwash.

[0061] Examples of the dosage forms of the cosmetics or external skin preparations of the present invention preferably include emulsion - type cosmetics such as oil - in - water (O / W) type, water - in - oil (W / O) type, W / O / W type, O / W / O type, oily cosmetics, solid cosmetics, liquid cosmetics, paste - like cosmetics, stick - like cosmetics, volatile oil - type cosmetics, powdery cosmetics, jelly - like cosmetics, gel - like cosmetics, paste - like cosmetics, emulsion polymer - type cosmetics, sheet - like cosmetics, mist - like cosmetics, spray - type cosmetics, etc.

[0062] The present invention will be described in more detail with reference to the following examples, but the present invention is not limited thereto.

[0063] <Cholesterol synthesis promoting effect> Normal human epidermal keratinocytes were seeded in a 24 - well flat - bottom plate at a concentration of 1.0×10 5 cells / well, cultured in HuMedia - KB2 medium (manufactured by Kurabo Industries Ltd.) for 16 hours, then phosphorylcholine was added to the medium at a concentration of 100 ppm, and further cultured for 24 hours. Then, the gene expression level of hydroxymethylglutaryl CoA reductase (HMGCR) (normalized by GAPDH) was measured by real - time PCR. As a control, the gene expression level without the test substance added was measured in the same manner. The results are shown in Table 1 as relative values using the average value of 3 wells with the expression level of the control set to 100.

[0064]

Table 1

[0065] From the results in Table 1, it was found that phosphocholine significantly increased the gene expression level of HMGCR compared to the control. HMGCR is the rate-limiting enzyme in the cholesterol biosynthesis process, and it is known that intracellular cholesterol synthesis is regulated by the activity of HMGCR. Therefore, the increase in HMGCR gene expression in the epidermis leads to the promotion of cholesterol synthesis in the epidermis.

[0066] <Antibacterial effect> For the phosphocholine aqueous solution, a preservation efficacy test was conducted according to the method described in the Japanese Pharmacopoeia. In the test, Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa were used as bacteria, and Candida albicans and Aspergillus brasiliensis were used as fungi. The results are shown in Table 2.

[0067]

Table 2

[0068] From the results in Table 2, it was found that phosphocholine exhibits an antibacterial effect against bacteria and some fungi.

[0069] <Confirmation of the formation of deep eutectic solvents 1> Using phosphocholine and various components (B) listed in Table 3, the presence or absence of the formation of deep eutectic solvents was confirmed by the following method. The results are also shown in Table 3. Method for confirming the presence or absence of deep eutectic solvent formation Component (A) and (B) were weighed into an eggplant flask at the ratios shown in Table 3, and ethanol three times the total mass of components (A) and (B) was added. The mixture was heated and dissolved at 70 °C. Then, the ethanol was distilled off using an evaporator. After cooling to room temperature, the appearance of the resulting composition was visually observed. Those showing a liquid state at room temperature were judged to have formed a deep eutectic solvent, and those not showing it were judged not to have formed a deep eutectic solvent (in the table, the case of forming a deep eutectic solvent is indicated by ○, and the case of not forming is indicated by ×).

[0070]

Table 3

[0071] From the results in Table 3, it was confirmed that all the compounds of component (B) described in Table 3 formed deep eutectic solvents.

[0072] <Confirmation of Deep Eutectic Solvent Formation 2> Using phosphocholine and various components (B) described in Table 4, the formation of deep eutectic solvents when changing the blending ratio of components (A) and (B) was confirmed by the same method as above.

[0073]

Table 4

[0074] From the results in Table 4, it was confirmed that the range of the ratio of forming deep eutectic solvents differed depending on the type of component (B).

[0075] <Crystal Precipitation Inhibition> Lotions containing components (A) and (B) were prepared with the compositions described in Table 5. For the obtained lotions, the inhibition of phosphocholine crystal precipitation was confirmed by the following method. Method for confirming suppression of crystal precipitation 3 g of each lotion was added to a petri dish with a diameter of 3.5 cm and dried at 40 °C for 24 hours. The appearance of the petri dish after drying was visually observed, and the inhibition of crystal precipitation was evaluated according to the following evaluation criteria. Evaluation Criteria ○: No crystal precipitation △: Crystal precipitation was suppressed compared to Comparative Example 1 ×: The same amount of crystals as in Comparative Example 1 precipitated

[0076]

Table 5

[0077] From the results in Table 5, it was confirmed that by combining and formulating components (A) and (B), the crystal precipitation of phosphocholine was suppressed.

[0078] <Evaluation of Use Feeling> Lotions containing components (A) and (B) were prepared with the compositions described in Table 6. For the obtained lotions, the feeling of use when applied to the skin or hair by the following method was evaluated. Method for evaluating usability (Skin) 0.05 g of each lotion was dropped onto the inner part of the forearm, and while spreading it on the skin with a finger, the feeling of smoothness, moistness, and stickiness after drying was evaluated based on the senses of 5 panelists according to the following evaluation criteria. The results were shown as the average score of the 5 panelists' scores. (Hair) 0.5 g of each lotion was evenly applied to 3 g of a bundle of healthy black human hair while kneading it with a finger, and the feeling of smoothness, moistness, and stiffness after drying was evaluated based on the senses of 5 panelists according to the following evaluation criteria. The results were shown as the average score of the 5 panelists' scores. Evaluation Criteria 5 points: Considerably better than Comparative Example 2 4 points: Better than Comparative Example 2 3 points: Equivalent to Comparative Example 2 2 points: Worse than Comparative Example 2 1 point: Considerably worse than Comparative Example 2

[0079]

Table 6

[0080] From the results in Table 6, although the improved usability varies depending on the components, it was confirmed that by combining and formulating components (A) and (B), the usability was improved as compared with the case of formulating component (A) alone.

[0081] Example 18 Lotion Component Blending amount (wt%) ---------------------------------------- Part A Phosphocholine (70% aqueous solution) 1.0 1,3-Butylene glycol 4.0 Inositol 0.5 Glycyrrhizic acid 2K 0.01 Ethanol 3.0 Phenoxyethanol 0.2 Methylparaben 0.15 Citric acid 0.1 Sodium citrate Amount to make pH 4.5 Purified water Amount to make a total of 100 Part B Xanthan gum 0.05 Glycerin 3.0 Purified water 20.0 Part C 3-O-Ethyl ascorbic acid (Nippon Fine Chemical) 0.1 Purified water 5.0 ---------------------------------------- (Preparation method) Part B was mixed to prepare a viscous liquid. Part A was heated to about 80 °C and uniformly dissolved. Part B was slowly added to Part A with stirring, cooled to 40 °C, and then Part C was added to make a uniform liquid.

[0082] Example 19 Lotion Component Blending amount (wt%) ---------------------------------------- Part A Phytopresome MEL (Nippon Seika) 3.0 Dipropylene glycol 3.0 Glycerin 1.0 Part B Purified water 20.0 Part C Phosphocholine (70% aqueous solution) 2.0 Neosolue-Aqulio (Nippon Seika) 0.5 Nicotinamide 5.0 Tranexamic acid (Nippon Seika) 1.0 Betaine 1.0 Phenoxyethanol 0.2 Methylparaben .15 Purified water in an amount to make a total of 100 ---------------------------------------- (Preparation method) The components of Part A were mixed and slowly added to Part B with stirring. Further, the pre-mixed Part C was added to make a uniform liquid.

[0083] Example 20 Skin Lotion Components Blending amount (wt%) --------------------------------------- Part A Phosphocholine (70% aqueous solution) 2.0 Diglycerin 3.0 Erythritol 1.0 Hydrolyzed hyaluronic acid 0.01 Arginine 0.05 Neosolue-AquaS (Nippon Seika) 1.0 Betaine 0.5 Pullulan 0.5 Hydroxyethyl cellulose 0.03 Carbomer 0.05 Arginine 0.05 Phenoxyethanol 0.2 Methylparaben 0.15 Purified water in an amount to make a total of 100 Part B Tremoist-TP 0.01 Inulin-SC (Nippon Seika) 1.0 Sodium hyaluronate 0.01 Purified water 10.0 --------------------------------------- (Preparation method) Part A was heated to about 80 °C and mixed uniformly. Part B was added to make a uniform liquid.

[0084] Example 21 Skin lotion Ingredient Blending amount (wt%) ---------------------------------------- Part A Phosphocholine (70% aqueous solution) 1.0 Diglycerin 3.0 Trehalose 0.5 Nicotinamide 5.0 Neosolue-AquaS (Nippon Seika) 1.0 PEG / PPG / Polybutylene glycol - 8 / 5 / 3 glycerin 0.5 Glucosylceramide 0.5 Glucosylrutin 0.01 Polyquaternium-51 0.5 Acetyl hexapeptide-8 0.001 Hydrolyzed collagen 0.05 Carbomer 0.05 Arginine 0.05 Phenoxyethanol 0.2 Methylparaben 0.15 Xanthan gum 0.1 Purified water in an amount to make a total of 100 Part B Tremoist-TP (Nippon Seika) 0.01 Inulin-SC (Nippon Seika) 0.1 Purified water 10.0 ---------------------------------------- (Preparation method) Part A was uniformly dissolved at about 80°C, and Part B was added to make a uniform liquid.

[0085] Example 22 Lotion Ingredient Dosage (wt%) ---------------------------------------- Part A Phosphocholine (70% aqueous solution) 1.0 Neosolue-Aqulio (Nippon Seika) 1.0 PEG / PPG / Polybutylene glycol-8 / 5 / 3 glycerin 0.5 Sorbitol 0.3 Carbomer 0.05 Arginine 0.05 Urea 0.2 Phenoxyethanol 0.4 Xanthan gum 0.1 EDTA-2Na 0.05 Purified water Amount to make a total of 100 Part B Tremoist-TP (Nippon Seika) 0.01 Fucoidan 0.01 Purified water 10.0 ---------------------------------------- (Preparation method) Part A was uniformly dissolved at about 80°C, and Part B was added to make a uniform liquid.

[0086] Example 23 Lotion Ingredient Dosage (wt%) --------------------------------------- Part A Phosphocholine (70% aqueous solution) 1.0 Neosolue-Aqulio (Nippon Fine Chemical) 1.0 Inositol 1.5 Isosorbide 1.0 PPG-6 Decyltetradeceth-30 0.2 PEG-60 Hydrogenated Castor Oil 0.2 PEG-30 Phytosterol 0.1 Coconut Oil Hydrolyzed Collagen K 0.5 Carbomer 0.05 Arginine 0.05 Phenoxyethanol 0.4 Hydroxyethyl Cellulose 0.1 Purified Water in an amount to make a total of 100 Part B Sodium Hyaluronate 0.01 Carrageenan 0.05 Citric Acid 0.01 Sodium Citrate 0.05 Purified Water 10.0 Part C Fragrance Appropriate amount Ethanol 3.0 --------------------------------------- (Preparation Method) Part A was uniformly dissolved at about 80°C, and Parts B and C were added to make a uniform liquid.

[0087] Example 24 Skin Lotion Ingredients Blending Amount (wt%) ---------------------------------------- Part A Neosolue-AquaS (Nippon Fine Chemical) 1.0 Diglycerin 2.0 Polyglyceryl-10 Laurate 0.3 Polyglyceryl-10 Decamachadamia Nut Fatty Acid 0.6 Betaine 1.0 Pyridoxine palmitate 0.1 Part B Phosphocholine (70% aqueous solution) 2.0 Arbutin (Nippon Seika) 1.5 Glycyrrhizic acid 2K 0.1 Phenoxyethanol 0.4 Purified water in an amount to make a total of 100 Part C Tremoist-TP (Nippon Seika) 0.01 Purified water 10.0 ---------------------------------------- (Preparation method) Parts A and B were heated to form a uniform liquid. While stirring Part A, Part B was gradually added to form a uniform liquid. After cooling, Part C was added and made uniform.

[0088] Example 25 Skin lotion Component Blending amount (wt%) ---------------------------------------- Part A Phosphocholine (70% aqueous solution) 2.0 Glycerin 10.0 Xanthan gum 0.05 (Acrylates / Alkyl acrylate (C10-30)) Crosspolymer 0.08 KOH 0.04 Cellulose gum 0.04 Purified water in an amount to make a total of 100 Part B Plandool-LG3 (Nippon Seika) 0.1 Carinodendron orinocense seed oil 0.1 PEG-40 hydrogenated castor oil 0.1 Dimethicone 0.2 Stearyl glycyrrhetinate 0.05 Part C β-Glucan 0.1 Inulin-SC (Nippon Seika) 0.5 Phenoxyethanol 0.4 Purified water 10.0 ---------------------------------------- (Preparation method) Parts A and B were heated to form a uniform liquid. While stirring Part A, Part B was gradually added to form a uniform liquid. After cooling, Part C was added to make it uniform.

[0089] Example 26 Gel Component Blending amount (wt%) ------------------------------------ Part A Phytocompo-PP (Nippon Seika) 1.0 Glycerin 5.0 Sorbitol solution (70% aqueous solution) 5.0 Glyceryl behenate 0.8 Stearic acid 0.3 PEG-10 dimethicone 0.4 Part B Phosphocholine (70% aqueous solution) 3.0 Phenoxyethanol 0.3 Pullulan 0.2 Ethylhexylglycerin 0.2 Polymethacryloyl lysine 0.05 Crystalline cellulose powder 0.1 Locust bean gum 0.03 Hydroxyethyl cellulose 0.05 Sodium hyaluronate 0.01 Carbomer 0.06 Sodium benzoate 0.05 Potassium hydroxide 0.05 Purified water An amount that totals 100 Part C Tremoist-TP (Nippon Seika) 0.1 Purified water 10.0 ------------------------------------- (Preparation method) The A part was heated to about 70 °C and uniformly dispersed. The B part was mixed, stirred well to make it uniform, and then heated to about 70 °C. The B part was added to the A part, and stirred using a homomixer at about 70 °C, cooled to about 40 °C, and the C part was added.

[0090] Example 27 Gel Component Dosage (wt%) --------------------------------------- Part A Phosphocholine (70% aqueous solution) 2.0 Glycerin 3.0 Polyglycerin 0.2 Methyl gluceth - 10 1.0 Phenoxyethanol 0.3 Pyridoxine hydrochloride 0.05 Ethylhexylglycerin 0.2 Hydroxyethyl cellulose 0.05 Hydrolyzed collagen 0.01 Purified water An amount to make a total of 100 Part B (Dimethyl taurine ammonium acrylate / vinyl pyrrolidone) copolymer 0.05 (Acrylates / acrylic acid alkyl (C10 - 30)) cross - polymer 0.15 Arginine 0.25 Purified water 30.0 ---------------------------------------- (Preparation method) The A part was stirred to make a uniform liquid. The B part was mixed to make a viscous liquid. The B part was added to the A part and made uniform.

[0091] Example 28 Emulsion Component Dosage (wt%) --------------------------------------- A part Plandool-DP (Nippon Seika) 1.0 Cetyl ethylhexanoate (Nippon Seika) 10.0 Cetanol 1.2 Phenyltrimethicone 3.0 Ethylparaben 0.1 Myristyl alcohol 2.0 Oleyl alcohol 1.0 Part B Stearoxyhydroxypropylmethylcellulose 0.1 Xanthan gum 0.1 Purified water 20.0 Part C Phytocompo-PP (Nippon Seika) 1.0 1,2-Pentanediol 3.0 Glycerin 8.0 Part D 3-O-Ethylascorbic acid (Nippon Seika) 1.0 Purified water 5.0 Part E Phosphocholine (70% aqueous solution) 1.0 Phenoxyethanol 0.2 Methylparaben 0.15 Phytic acid 0.5 Citric acid 0.1 Sodium citrate Amount to adjust pH to 4.5 Purified water Amount to make a total of 100 --------------------------------------- (Preparation method) Part A and Part E were each heated to approximately 70°C and dissolved uniformly. Part B was stirred to form a viscous liquid. Part C was heated to approximately 70°C and dispersed uniformly. While stirring Part C with a homodisper, Part A was added, and then Part E was added while stirring. At approximately 50°C, Part D and Part B were added and stirred to dissolve uniformly.

[0092] Example 29 Emulsion Component Dosage (wt%) ------------------------------------- Part A Glycerin 3.0 Diglycerin 1.0 1,3 - Butylene Glycol 7.0 Phytocompo - C (Nippon Seika) 1.0 LP70H (Nippon Seika) 0.1 Part B LUSPLAN PI - DA (Nippon Seika) 3.0 LUSPLAN DD - DHR (Nippon Seika) 0.5 Hydrogenated Polyisobutene 3.5 Isododecane 1.5 Cetostearyl Alcohol 1.0 Arachidyl Alcohol 0.1 Jojoba Alcohol 3.0 Kimil Alcohol 0.3 Cerakyl Alcohol 0.1 Hexyldecanol 0.5 Part C (Hydroxyethyl Acrylate / Acryloyldimethyl Taurine Na) Copolymer 0.2 Tremoist - TP (Nippon Seika) 0.03 Carbomer 0.1 Purified Water 20.0 Part D Phosphocholine (70% Aqueous Solution) 1.0 Neosolue - AquaS (Nippon Seika) 0.5 Polyquaternium - 51 1.0 Ascorbic Acid Glucoside 1.0 Potassium Hydroxide 0.2 Phenoxyethanol 0.2 Methylparaben 0.15 Purified Water in an amount to make a total of 100 ------------------------------------- (Preparation Method) The A part, B part, and D part were each mixed, heated to about 70 °C, and uniformly dissolved and dispersed. The C part was mixed and stirred to form a viscous liquid. While stirring the A part with a homodisper, the B part was added, and then the D part was added and emulsified. After cooling to about 50 °C, the C part was added and stirred until cooled to about 40 °C.

[0093] Example 30 Skin Care Cream Component Blending amount (wt%) ------------------------------------- Part A Glycerin 9.0 Dipropylene glycol 5.0 Phytocompo-PP (Nippon Seika) 1.0 Part B Petrolatum 10.0 Pentaerythrityl tetraisostearate 5.0 LUSPLAN DD-DA7 (Nippon Seika) 1.0 Cetyl PG-hydroxyethyl palmitamide 0.05 Sodium cyclic lysophosphatidic acid 0.01 Dipentaerythrityl hexahydroxystearate 1.0 Part C Carbomer 0.1 Potassium hydroxide 0.07 Xanthan gum 0.1 Purified water 10.0 Part D Phosphocholine (70% aqueous solution) 1.0 Phenoxyethanol 0.4 Malic acid 0.1 Ethylhexylglycerin 0.2 Methylparaben 0.05 Purified water An amount to make a total of 100 ------------------------------------- (Preparation method) Parts A, B, and D were each mixed, heated to about 70 °C, and uniformly dissolved and dispersed. Part C was mixed and stirred to form a viscous liquid. While stirring Part A with a homodisper, Part B was added, and then Part D was added and emulsified. After cooling to about 50 °C, Part C was added and stirred until cooled to about 40 °C.

[0094] Example 31 Skin Care Cream Component Blending Amount (wt%) ------------------------------------- Part A Squalane 10.0 Stearic Acid 1.0 Plandool-ISS (Nippon Seika) 1.0 Macadamia Nut Oil 3.0 Hydrogenated Rapeseed Oil Alcohol 2.0 Cetearyl Olive Oil Fatty Acid 1.0 Sorbitan Olive Oil Fatty Acid 0.8 Polyglyceryl-10 Oleate 1.0 Part B Acrylic Acid / Alkyl Methacrylate Copolymer 0.1 Potassium Hydroxide 0.07 (Acryloyldimethyltaurine Ammonium / Beheneth-25 Methacrylate) Crosspolymer 0.2 Tremoist-SL (Nippon Seika) 1.0 Purified Water 10.0 Potassium Hydrolyzed Polyγ-Glutamic Acid 0.1 Sodium Polyglutamate 0.1 Oligopeptide-24 0.05 Part C Phosphocholine (70% Aqueous Solution) 1.0 Glycerin 9.0 Propanediol 10.0 PEG-8 5.0 Methylparaben 0.1 Phenoxyethanol 0.3 Purified Water An amount to make 100 in total ------------------------------------- (Preparation Method) Part A and Part C were each mixed, heated to about 70°C, and uniformly dissolved and dispersed. Part B was mixed and stirred to form a viscous liquid. While stirring Part C with a homomixer, Part A was added and emulsified. After cooling to about 50°C, Part B was added and stirred until cooled to about 40°C.

[0095] Example 32 Skin Care Cream Ingredient Dosage (wt%) ------------------------------------- Part A Plandool-MAS (Nippon Seika) 2.0 Plandool-LG1 (Nippon Seika) 1.0 Plandool-LG4 (Nippon Seika) 1.0 Paraffin Wax 3.0 Shea Butter 3.0 Squalane 8.0 Cetanol 1.8 Hydrogenated Cocoglyceryl 0.8 Glyceryl Stearate 1.0 Behenyl Alcohol 1.5 Sorbitan Stearate 1.0 Methyl Glucose Sesquistearate 1.5 Part B Xanthan Gum 0.1 Hydroxyethyl Cellulose 0.1 Crystalline Cellulose Powder 0.3 Stearoxy Hydroxypropyl Methylcellulose 0.1 Purified Water 20.0 Part C Phosphocholine (70% Aqueous Solution) 1.0 Glycerin 8.0 Dipropylene Glycol 5.0 Sorbitol 2.0 Methylparaben 0.15 Purified water in an amount totaling 100 ------------------------------------- (Preparation method) Part A and Part C were each mixed, heated to about 70°C, and uniformly dissolved and dispersed. Part B was mixed and stirred to form a viscous liquid. While stirring Part C with a homomixer, Part A was added and emulsified. After cooling to about 50°C, Part B was added and stirred until cooled to about 40°C.

[0096] Example 33 Skin Care Cream Ingredient Dosage (wt%) -------------------------------------- Part A Glycerin 9.0 Phytocompo-C (Nippon Seika) 1.0 Glucosylrutin 0.001 Part B Argania spinosa kernel oil 1.0 Theobroma grandiflorum seed butter 1.0 Astaxanthin 0.005 Ethylhexyl stearate 3.0 Plandool-ISS (Nippon Seika) 2.0 Carnauba wax 0.5 Steareth-2 2.5 Steareth-21 1.8 Cetyl alcohol 3.0 Tocopheryl acetate 0.03 Squalane 3.0 Part C Carbomer 0.1 Arginine 0.1 Hydroxypropyl chitosan 0.2 Ethanol 3.0 Purified water 10.0 Panthenol 0.5 Retinol palmitate 0.05 Part D Phosphocholine (70% aqueous solution) 1.0 Succinic acid 0.1 Sodium succinate 0.15 Methylparaben 0.15 Purified water in an amount to make 100 in total -------------------------------------- (Preparation method) Parts A, B, and D were each mixed, heated to about 70°C, and uniformly dissolved and dispersed. Part C was mixed and stirred to form a viscous liquid. While stirring Part A with a homodisper, Part B was added, and then Part D was added and emulsified. After cooling to about 50°C, Part C was added and stirred until cooled to about 40°C.

[0097] Example 34 Skin care cream Ingredient Blending amount (wt%) ------------------------------------- Part A Glycerin 12.0 1,3-Butylene glycol 6.0 Phytocompo-PP (Nippon Seika) 2.5 Part B Olive fruit oil 3.0 Olive oil 1.5 Shea butter 1.0 Neosolue-DiSM (Nippon Seika) 3.0 Sucrose stearate 0.8 Cetearyl glucoside 1.2 Behenyl alcohol 1.5 Ascorbyl tetrahexyldecanoate 7.0 Isopropyl lauroyl sarcosinate 2.0 Hydrogenated coco-glyceryl 3.0 Cetanol 2.5 Sorbitan stearate 0.8<\ Part C Xanthan gum 0.05 Tremoist-SL (Nippon Seika) 1.0 Tuberose polysaccharide 0.01 Water-soluble collagen 0.05 Hydrolyzed collagen 0.5 Sodium pyrosulfite 0.03 Arbutin (Nippon Seika) 1.0 Tranexamic acid (Nippon Seika) 1.0 Part D Phosphocholine (70% aqueous solution) 1.0 Neosolue-Aqulio (Nippon Seika) 1.0 Propanediol 3.0 Methylparaben 0.1 Purified water in an amount to make a total of 100 --------------------------------------- (Preparation method) Parts A, B, and D were each mixed, heated to about 70°C, and uniformly dissolved and dispersed. Part C was mixed and stirred to form a viscous liquid. After adding Part B while stirring Part A with a homodisper, Part D was added and emulsified. After cooling to about 50°C, Part C was added and stirred to cool to about 40°C.

[0098] Example 35 Skin care cream Ingredient Blending amount (wt%) ------------------------------------- Part A Plandool-SUN (Nippon Seika) 1.0 Diethylhexyl sebacate 10.0 Stearic acid 1.0 Moringa oil 3.0 Argania spinosa kernel oil 0.5 Hydrogenated rapeseed oil alcohol 2.0 Glyceryl stearate 1.0 Sorbitan sesquioleate 0.8 PEG-40 hydrogenated castor oil 1.0 Part B Acrylic acid / methacrylic acid alkyl copolymer 0.1 Potassium hydroxide 0.07 Polyacrylate Crosspolymer-11 0.2 Tremoist-SL (Nippon Seika) 1.0 Purified Water 10.0 Palmitoyl Tetrapeptide-7 0.05 Part C Phosphocholine (70% Aqueous Solution) 1.0 Glycerin 5.0 PEG-8 5.0 Methylparaben 0.1 Phenoxyethanol 0.3 Purified Water in an amount to make 100 in total ------------------------------------- (Preparation Method) Parts A and C were each mixed, heated to about 70°C, and uniformly dissolved and dispersed. Part B was mixed and stirred to form a viscous liquid. While stirring Part C with a homomixer, Part A was added and emulsified. It was cooled, and at about 50°C, Part B was added and stirred until cooled to about 40°C.

[0099] Example 36 Hand Cream Ingredient Dosage (wt%) --------------------------------- Part A Neosolue-DiSM 8.0 Plandool-MAS (Nippon Seika) 5.0 LUSPLAN DD-DHR (Nippon Seika) 0.1 Squalane 8.0 Macadamia Nut Oil 0.5 Rose Hip Oil 1.0 Meadowfoam Oil 1.0 Petrolatum 15.0 Microcrystalline Wax 2.0 Glyceryl Stearate 2.0 Cetanol 2.0 Cetyl Phosphate 1.0 Beeswax 3.0 Propylparaben 0.1 Tocopherol 0.05 Perfluoropolyether 1.0 Part B Phosphocholine (70% aqueous solution) 1.0 Glycerin 8.0 Propanediol 5.0 Methylparaben 0.1 Ethylhexylglycerin 0.5 Phenoxyethanol 0.3 Sodium hydroxide 0.5 Water in an amount to make 100 in total [[ID=#]]--------------------------------- (Preparation method) Part B was heated to about 70 °C and dissolved. Part A was taken in another container and heated to about 80 °C and dissolved. Part A was added to Part B with stirring using a homomixer and emulsified. After emulsification, it was cooled to about 40 °C.

[0100] Example 37 Cleansing Gel[[ID=3#]] Components Blending amount (wt%) --------------------------------- Part A Diethylhexyl succinate (Nippon Fine Chemical) 10.0 Plandool-H (Nippon Fine Chemical) 1.0 LUSPLAN DD-IS (Nippon Fine Chemical) 8.0 PEG-25 hydrogenated castor oil 20.0 Octyldodeceth-20 15.0 Part B Phosphocholine (70% aqueous solution) 1.0 Glycerin 10.0 Xylitol 2.0 1,3-Butylene glycol 5.0 Phenoxyethanol 0.5 Purified water in an amount to make 100 in total --------------------------------- (Preparation method) Part A and Part B were each heated to about 80 °C and dissolved. They were mixed and heated to about 80 °C. While stirring, Part B was gradually added to Part A, and after mixing, it was cooled to 40 °C.

[0101] Example 38 Cleansing Cream Component Dosage (wt%) --------------------------------- Part A Neosolue-DE (Nippon Seika) 5.0 Glycerin 3.0 Plandool-LG2 (Nippon Seika) 1.0 Neosolue-Aqulio (Nippon Seika) 1.0 Ceresin 6.0 Mineral oil 28.0 PEG-12 isostearate 3.0 Sorbitan sesquioleate 1.5 Polyoxyethylene sorbitan oleate 0.3 Microcrystalline wax 2.0 Tocopherol 0.05 Propylparaben 0.05 Part B Phosphocholine (70% aqueous solution) 1.0 Dipropylene glycol 5.0 Methylparaben 0.2 Trisodium edetate 0.02 Phenoxyethanol 0.2 Purified water An amount that totals 100 --------------------------------- (Preparation method) Part A and Part B were each heated to about 80 °C and dissolved. They were mixed and heated to about 80 °C. While stirring, Part B was gradually added to Part A, and after mixing, it was cooled to 40 °C.

[0102] Example 39 Facial Wash Foam Component Dosage (wt%) ----------------------------------- Part A Potassium stearate 10.0 Potassium palmitate 10.0 Potassium myristate 10.0 Potassium laurate 4.0 Isopropyl lauroyl sarcosinate 0.8 PEG1500 10.0 Glycerin 15.0 Glyceryl monostearate 1.0 POE(20) sorbitan monostearate 2.0 Part B Phosphocholine (70% aqueous solution) 1.0 Trehalose 0.5 Polyquaternium-7 0.5 Polyquaternium-39 0.5 Methylparaben 0.1 Purified water in an amount to make 100 in total ----------------------------------- (Preparation method) Part A was heated to about 80 °C and dissolved. Part B was heated to about 80 °C. While stirring, Part B was gradually added to Part A, and after mixing, it was cooled to 40 °C.

[0103] Example 40 Facial wash foam Ingredient Blending amount (wt%) --------------------------------- Part A (Coconut fatty acid / hydrogenated tallow fatty acid) Sodium glutamate 30.0 Cocoyl glycine potassium 5.0 Plandool-LG2 (Nippon Seika) 0.2 Lauric acid diethanolamide 3.0 Tocopherol 0.1 PEG-8 5.0 PEG-32 10.0 Glycerin 14.0 Propylparaben 0.1 Part B Phosphocholine (70% aqueous solution) 1.0 Isopropylmethylphenol 0.15 Methylparaben 0.2 Polyquaternium-51 1.0 Crystalline cellulose 0.3 Polyquaternium-7 0.8 Purified water in an amount to make a total of 100 Part C Tremoist-TP (Nippon Seika) 0.02 Purified water 10.0 --------------------------------- (Preparation method) Part A was heated to about 80°C and dissolved. Part B was heated to about 80°C. While stirring, Part B was gradually added to Part A, and after mixing, it was cooled to 40°C. Part C was added and mixed uniformly.

[0104] Example 41 Body shampoo Ingredient Blending amount (wt%) --------------------------------- Part A Potassium cocoate, Potassium myristate 10.0 Cocoyl methyl taurine Na 1.5 Cocamide DEA 5.0 EDTA-2Na 0.1 Ethyl glycerin 1.0 Glycerin 10.0 Phosphocholine (70% aqueous solution) 3.0 Cocamidopropyl betaine 5.0 Phenoxyethanol 0.4 Purified water in an amount to make a total of 100 --------------------------------- (Preparation method) Part A was heated at about 80°C and stirred and mixed uniformly.

[0105] Example 42 Body Shampoo Ingredient Dosage (wt%) --------------------------------- Part A Coconut oil methyl taurine Na 10.0 Lauroyl hydrolyzed silk Na 6.0 Lauroyl methyl alanine Na 10.0 Cocoa amphoacetate Na (30%) 4.0 Cocamidopropyl betaine (30%) 10.0 Olefin (C14-16) sulfonic acid Na 5.0 Polyquaternium-10 1.3 Guar hydroxypropyltrimonium chloride 0.8 Sodium acetyl hyaluronate 0.02 Cocamide DEA 3.0 Phosphocholine (70% aqueous solution) 1.0 Glycerin 5.0 Methylparaben 0.2 Purified water An amount to make a total of 100 Part B Tremoist-TP (Nippon Seika) 0.02 Purified water 10.0 --------------------------------- (Preparation method) Part A was heated at about 80 °C and stirred and mixed uniformly. It was cooled to about 40 °C, and Part B was added and mixed uniformly.

[0106] Example 43 Non-silicone Shampoo Ingredient Dosage (wt%) --------------------------------- Part A Plandool-LG2 (Nippon Seika) 0.03 Neosolue-AquaS (Nippon Seika) 0.1 Phosphocholine (70% aqueous solution) 1.0 Malic acid 0.5 Sodium laures-4-carboxylate (28%) 10.0 Lauric-6-carboxylic acid 4.0 Cocamidopropyl betaine (30%) 10.0 Sodium lauroyl methyl alaninate (30%) 5.0 Cocamidomethyl MEA 3.0 PEG-7 glyceryl coconut oil fatty acid 5.0 1% NaOH solution 0.5 Polyquaternium-10 0.8 Glycol distearate 0.5 Polyquaternium-7 0.5 EDTA-2Na 0.05 Methylparaben 0.2 Phenoxyethanol 0.4 Purified water in an amount to make a total of 100 --------------------------------- (Preparation method) Part A was heated at about 80°C and stirred and mixed uniformly.

[0107] Example 44 Non-rinse hair treatment Ingredient Dosage (wt%) ------------------------------------- Part A Polyquaternium-37 2.0 Squalane 2.0 PPG-3 caprylyl ether 2.0 Microcrystalline wax 0.1 Lanolin alcohol 0.2 Montan wax 0.1 Polyethylene wax 0.1 Beeswax 0.1 Carnauba wax 0.2 Ceresin 0.1 PG dicaprylate 1.0 Almond oil 0.5 Ethylhexyl ethylhexanoate 1.0 Candelilla wax extract 0.1 Octyldodecyl erucate 4.5 Tocopherol acetate 0.02 Erucalactone MCT (Nippon Seika) 2.0 Dipentaerythrityl tripolyhydroxystearate 1.5 PPG-5 phytosterol 0.5 Glycerin 4.0 Sorbitol 2.0 Phenoxyethanol 0.5 Part B Phosphocholine (70% aqueous solution) 1.0 Succinic acid 0.1 Hydrolyzed conchiolin 0.1 Panthenol 0.1 Hydroxypropyltrimonium hyaluronate 0.01 Polyquaternium-11 0.2 Glycosyl trehalose 0.1 Glyceryl glucoside 0.3 Arginine 0.1 Part C Purified water in an amount to make a total of 100 Hydroxypropyl starch phosphate 1.0 -------------------------------------- (Preparation method) Part C was uniformly dispersed and heated to about 80°C. Next, Part A was heated to about 80°C and dissolved. While stirring Part C, Part A was added, and after uniformly mixing, it was cooled to about 40°C. Then, Part B was added and uniformly mixed.

[0108] Example 45 Hair treatment Ingredient Blending amount (wt%) ------------------------------------ Part A Dodecane 1.5 Neosolue-Aqulio (Nippon Seika) 0.2 Plandool-H (Nippon Seika) 1.0 Candelilla wax 0.2 Cetyl esters 0.3 Stearyl ethylhexanoate 1.0 Ceteareth-3.5 PEG-200 0.5 Hydroxyethyl cellulose 0.4 Cetrimonium chloride (30%) 1.0 Behentrimonium chloride (80%) 1.0 Trideceth-6 0.3 BHT 0.03 Part B Phosphocholine (70% aqueous solution) 1.0 Methylparaben 0.2 Citric acid 0.05 Purified water in an amount to make a total of 100 Part C PPG-3 myristyl ether 0.5 Diethylhexyl sebacate (Nippon Seika) 1.0 Part D Tremoist-TP (Nippon Seika) 0.02 Purified water 10.0 ------------------------------------- (Preparation method) Part B was heated to about 80 °C and dissolved. Part A was added to a separate container, heated, and dissolved. Part B was gradually added to Part A and mixed uniformly. Parts C and D were added with stirring at about 50 °C to make it uniform.

[0109] Example 46 Hair treatment Ingredient Dosage (wt%) -------------------------------------- Part A Plandool-LG2 (Nippon Seika) 0.5 Propanediol 3.0 Behenamidopropyl Dimethylamine 1.5 Cetanol 2.2 Stearyl Alcohol 0.8 Hydrogenated Rapeseed Oil Alcohol 0.5 Neopentyl Glycol Diethylhexanoate 0.8 Jojoba Seed Oil 1.0 Glyceryl Stearate 0.4 Propylparaben 0.1 Cocamide MEA 0.8 Caesalpinia Spinosa Hydroxypropyltrimonium Chloride 0.1 Rice Bran Wax 0.5 Glycerin 1.0 Part B Phosphocholine (70% Aqueous Solution) 1.0 Methylparaben 0.1 Malic Acid 0.4 Purified Water in an amount to make a total of 100 Part C Amodimethicone 3.0 Methylheptyl Caprylate 1.0 Polyquaternium-7 0.15 PPG-3 Benzyl Ether Myristate 0.5 Part D Tremoist-TP (Nippon Seika) 0.005 Purified Water 10.0 -------------------------------------- (Preparation Method) Part A was uniformly mixed at about 80°C. Separately taken Part B was heated to about 60°C and made uniform. Part B was gradually added to Part A while stirring, and after uniformly mixing, it was cooled to about 50°C. Further, Part C and Part D were added and uniformly mixed.

[0110] Example 47 Hair Treatment Ingredient Dosage (wt%) ------------------------------------ Part A Dodecane 1.5 Neosolue - Aqulio (Nippon Seika) 0.2 Candelilla wax 0.2 Cetyl esters 0.3 Stearyl ethylhexanoate 1.0 Ceteareth - 20 3.5 PEG - 200 0.5 Hydroxyethyl cellulose 0.4 Cetrimonium chloride (30%) 1.0 Behentrimonium chloride (80%) 1.0 Trideceth - 6 0.3 BHT 0.03 Part B Phosphatidylcholine (70% aqueous solution) 1.0 Methylparaben 0.2 Citric acid 0.05 Purified water in an amount to make a total of 100 Part C Dimethicone (3 million cs) 1.0 Dimethicone (100 cs) 3.0 PPG - 3 myristyl ether 0.5 Isodecyl neopentanoate (Nippon Seika) 1.0 ------------------------------------- (Preparation method) Part B was heated to about 80°C and dissolved. Part A was added to a separate container, heated, and dissolved. Part B was gradually added to Part A and mixed uniformly. Part C was added with stirring at about 50°C to make it uniform.

[0111] Example 48 Shampoo Ingredient Dosage (wt%) ------------------------------------ Part A Sodium lauroyl methyl alaninate (30%) 13.0 Cocamidopropyl betaine (30%) 20.0 TEA - cocoyl glutamate (30%) 5.0 Cocamide DEA 1.0 Glycerin 1.0 Glyceryl Caprylate 0.4 Glyceryl Undecylenate 0.1 Neosolue - AquaS (Nippon Seika) 1.0 Sorbitol 1.6 Polyquaternium - 7 0.3 Part B Phosphocholine (70% aqueous solution) 1.0 Sodium Benzoate 0.4 Salicylic Acid 0.2 Sodium Chloride 0.2 Purified Water in an amount to make 100 in total Part C Assembly Extract 3.0 Polyquaternium - 10 0.2 Guar Hydroxypropyltrimonium Chloride 0.1 Polyquaternium - 47 0.1 Purified Water 9.7 Part D Tremoist - TP (Nippon Seika) 0.01 Purified Water 10.0 ------------------------------------ (Preparation Method) Part B was heated to about 80°C and dissolved uniformly. Part A was taken in a separate container, heated, and dissolved. Part B was gradually added to Part A, mixed uniformly, and Part C was added at about 60°C. It was cooled to about 40°C, Part D was added, and mixed uniformly.

[0112] Example 49 Shampoo Ingredient Dosage (wt%) ---------------------------------- Part A PPG - 3 Caprylyl Ether 0.2 Ammonium Lauryl Sulfate 5.0 Sodium Lauryl Sulfate (25%) 10.0 Lauryl hydroxysultaine (30%) 10.0 Potassium laurate 1.0 Glycol distearate 0.5 Toluenesulfonic acid 0.3 Stearoxypropyl dimethylamine 0.5 PPG-17 0.3 Dimethicone 0.1 PEG-9 dimethicone 0.1 Amodimethicone 0.1 Diethylhexyl sebacate (Nippon Fine Chemical) 1.0 Neopentyl glycol diethylhexanoate 0.4 Lanolin fatty acid 0.3 Isodecyl glyceryl ether 0.4 Miconazole nitrate 0.75 Cocamide MEA 1.0 Laureth-4 0.3 Laureth-16 0.2 Steareth-6 0.2 Phenoxyethanol 0.3 Part B Phosphocholine (70% aqueous solution) 1.0 Malic acid 0.1 Methylparaben 0.2 Azelaic acid 0.03 Sodium benzoate 0.3 Purified water in an amount to make a total of 100 Part C Polyquaternium-10 0.2 Guar hydroxypropyltrimonium chloride 0.1 Purified water 6.7 ---------------------------------- (Preparation method) Part A was uniformly mixed at about 80°C. Separately taken Part B was heated to about 60°C and made uniform. Part B was gradually added to Part A with stirring, and after uniformly mixing, it was cooled to about 50°C. Further, Part C was added and uniformly mixed.

[0113] Example 50 Shampoo Component Blending amount (wt%) ---------------------------------- Part A Coconut oil methyl taurine Na (30%) 10.0 Lauryl hydroxysultaine (30%) 10.0 Glycol distearate 0.5 Naphthalenesulfonic acid 0.1 Isopropylmethylphenol 0.1 Stearoxypropyl dimethylamine 0.5 PEG-10 dimethicone 0.3 Cocamidomethyl MEA 1.0 Coconut oil fatty acid PEG-7 glyceryl 0.5 Polyglyceryl-2 diisostearate 0.3 PEG-50 lanolin 0.3 Phenoxyethanol 0.3 Part B Phosphocholine (70% aqueous solution) 1.0 Malic acid 0.1 Succinic acid 0.1 Sodium benzoate 0.3 Purified water An amount to make 100 in total Part C Polyquaternium-10 0.2 Guar hydroxypropyltrimonium chloride 0.1 Amodimethicone 0.3 Tremoist-SL (Nippon Seika) 3.0 Purified water 6.7 ---------------------------------- (Preparation method) Part A was uniformly mixed at about 80°C. Separately taken Part B was heated to about 60°C and made uniform. Part B was gradually added to Part A with stirring, and after uniformly mixing, it was cooled to about 50°C. Further, Part C was added and uniformly mixed.

[0114] Example 51 Leave-on Hair Treatment Component Dosage (wt%) ---------------------------------- Part A Neosolue-Aqulio (Nippon Fine Chemical) 2.0 Cetrimonium Chloride (25%) 3.8 Caprylyl Glucoside (50%) 0.8 Glycerin 4.0 Phenoxyethanol 0.5 Part B Ethanol 5.0 Part C Polyquaternium-6 0.6 Polyquaternium-7 0.4 Polyquaternium-39 0.5 Purified water Amount to make 100 in total Part D Phosphocholine (70% aqueous solution) 1.0 3-O-Ethyl Ascorbic Acid (Nippon Fine Chemical) 0.1 Inulin-SC (Nippon Fine Chemical) 0.1 Tremoist-TP (Nippon Fine Chemical) 0.005 Purified water 10.0 ---------------------------------- (Preparation Method) Part C was heated to about 80 °C and dissolved. Next, Part A was heated to about 80 °C and dissolved. While stirring Part C, Part A was added, and after uniformly mixing, it was cooled to about 40 °C. Then, Part B and Part D were added and uniformly mixed.

[0115] Example 52 Mousse Component Dosage (wt%) --------------------------------- Ethanol 5.0 Polyethylene Glycol Oleyl Ether (20) 1.0 Acrylic Resin Alkanolamine Solution 3.0 Diethylaminopropylamide stearate 0.5 Pyrrolidone carboxylic acid 0.2 Preservative, fragrance 1.0 Purified water in an amount to make 100 in total Phosphocholine (70% aqueous solution) 1.0 1,3-Butylene glycol 3.0 Tremoist-TP (Nippon Seika) 0.005 --------------------------------- (Preparation method) The above components were mixed, and the obtained base and LPG were mixed at a ratio of base:LPG = 92:8 to form an aerosol mousse.

[0116] Example 53 Styling milk Component Blending amount (wt%) --------------------------------- Part A LUSPLAN SR-DM4 (Nippon Seika) 1.0 Stearyl alcohol 1.7 Isopropyl palmitate (Nippon Seika) 1.2 Stearamidopropyldimethylamine 1.0 Plandool-H (Nippon Seika) 0.2 Cetes-20 0.3 Part B Phosphocholine (70% aqueous solution) 1.0 Phenoxyethanol 0.4 Lactic acid 0.4 Purified water in an amount to make 100 in total Part C Hydroxyethyl cellulose 0.4 1,3-Butylene glycol 2.0 --------------------------------- (Preparation method) Part A and Part B were each mixed at about 80°C. Part B was added to Part A for emulsification, cooled to about 60°C, and then Part C was added.

[0117] Example 54 Hair Color Treatment Component Dosage (wt%) -------------------------------------- Part A Neosolue-Aqulio (Nippon Fine Chemical) 1.0 Steartrimonium Chloride (70%) 2.5 Cation NH (Nippon Fine Chemical) 0.3 Cocamide DEA 1.0 Inulin Stearate 0.5 Lanolin Alcohol 0.2 Montan Wax 0.1 Polyethylene Wax 0.1 Beeswax 0.1 Dextrin Palmitate 0.3 Ceresin 0.1 PPG-3 Caprylate 1.0 PG Dicaprylate 1.0 Ethylhexyl Ethylhexanoate 1.0 Dicaprylyl Carbonate 1.5 Glycerin 4.0 Ceteareth-7 1.0 Isostearyl Alcohol 0.3 Rice Bran Oil 0.5 Glyceryl Stearate 0.5 Elucaractone DES (Nippon Fine Chemical) 1.5 Hydrogenated Polydecene 0.1 Ethyl Macadamiate 1.0 Lysine Na Dilauroyl Glutamate 0.1 Stearyl Behenedimonium Ethylphosphate 0.1 Tocopherol 0.05 Phenoxyethanol 0.3 Part B Phosphocholine (70% Aqueous Solution) 1.0 Purified Water 10.0 1,3-Butylene Glycol 2.0 Acylated hydrolyzed collagen 0.1 Panthenol 0.1 Hydroxyethyl cellulose 0.1 Polyquaternium-64 0.1 Polyquaternium-51 0.01 Polyquaternium-49 0.2 Phenoxyethanol 0.4 PCA-Na 0.1 Part C Purified water in an amount to make a total of 100 Basic Blue 99 0.1 Basic Brown 16 0.13 HC Blue 2 0.05 HC Yellow 2 0.03 HC Red 3 0.1 Hydroxyethyl urea 0.5 Arginine 0.2 Ammonium bicarbonate 1.0 -------------------------------------- (Preparation method) Part A was heated to about 80°C and dissolved. In a separate container, Part C was heated to about 80°C and dissolved. Part C was gradually added to Part A with stirring and uniformly mixed, and then rapidly cooled (Part D). Part B was added to Part D, which had reached about 40°C, to make it uniform.

[0118] Example 55 Hair manicure Ingredient Dosage (wt%) -------------------------------------- Part A Ethanol 10.0 Carnauba wax 0.01 Ceteareth-10 1.0 Elurolactone DES (Nippon Seika) 2.5 PPG-3 caprylyl ether 1.0 Diisopropyl sebacate (Nippon Seika) 1.0 PPG-3 caprylate 0.5 PG Dicaprylate 0.5 Dicaprylyl Carbonate 0.5 Part B Violet 401 0.2 Black 401 0.1 Orange 205 0.1 Red 102 0.1 Benzyl Alcohol 8.0 Ethanol 10.0 Part C Purified Water in an amount to make a total of 100 Phosphocholine (70% aqueous solution) 1.0 Citric Acid 2.0 (Acryloyldimethyltaurine Ammonium / VP) Copolymer 3.0 Glycolic Acid 2.0 Xanthan Gum 0.2 -------------------------------------- (Preparation Method) Part A and Part C were each mixed and made uniform. While stirring, Part C was added to Part B, and after uniformly mixing, Part A was added at about 60 °C and uniformly mixed.

[0119] Example 56 Water-containing Gloss Component Dosage (wt%) --------------------------------- Part A Octyldodecanol 27.0 Ethyl Cellulose 2.5 Neosolue-DiSM 10.0 LUSPLAN PI-DA (Nippon Fine Chemical) 2.0 LUSPLAN DD-DHR (Nippon Fine Chemical) 2.0 Plandool-MAS (Nippon Fine Chemical) 0.1 Plandool-H (Nippon Fine Chemical) 0.1 Dimethylsilylated Silica 0.2 Inulin Stearate 0.3 PEG-60 Hydrogenated Castor Oil 1.0 Red No. 202 Appropriate amount Yellow No. 4, appropriate amount Titanium oxide, appropriate amount Sorbitan stearate, sucrose cocoate mixture (manufactured by Croda Co., Ltd., ALACEL2121) 3.0 Part B Glycerin 7.0 Neosolue-AquaS (manufactured by Nippon Fine Chemical Co., Ltd.) 0.4 Maltose 2.0 Phenoxyethanol 0.2 Phosphocholine (70% aqueous solution) 1.0 Purified water, an amount to make a total of 100 ---------------------------------- (Preparation method) Heat and dissolve Part A and Part B respectively, add Part B to Part A, mix, and then cool to about 40°C.

[0120] Example 57 Liquid foundation Ingredient Blending amount (wt%) --------------------------------- Part A Plandool-G (manufactured by Nippon Fine Chemical Co., Ltd.) 5.0 Glyceryl stearate (SE) 1.0 PG stearate (SE) 1.0 Tocopherol 0.1 Propylparaben 1.0 Part B Titanium oxide - iron oxide mixture (manufactured by Toagosei Co., Ltd., FDP-W-007) 18.0 Mica 7.0 1,3-Butylene glycol 5.0 Phosphocholine (70% aqueous solution) 1.0 Methylparaben 0.2 Purified water, an amount to make a total of 100 Part C Cellulose gum (2% aqueous dispersion) 5.0 Xanthan gum (2% aqueous dispersion) 5.0 --------------------------------- (Preparation method) Part A, Part B, and Part C were heated and mixed. Part B was added to Part A and emulsified, then cooled to about 50 °C, and Part C was added and stirred until uniform.

[0121] Example 58 Liquid foundation Component Dosage (wt%) --------------------------------- Part A Purified water An amount that totals 100 Phosphocholine (70% aqueous solution) 1.0 Carboxyvinyl polymer 0.1 Potassium hydroxide Appropriate amount Dipropylene glycol 5.0 Preservative Appropriate amount Part B Polyoxyethylene-modified dimethylpolysiloxane 1.0 Trimethylsiloxysilicate 3.0 Phenylmethicone 1.0 Cyclomethicone 9.0 Part C Zinc white 10.0 Sericite 0.36 Titanium oxide 8.32 Iron oxide yellow 0.8 Iron oxide red 0.36 Iron oxide black 0.16 --------------------------------- (Preparation method) Part A was heated and stirred at 70 °C, then Part C was added and dispersed. This was preheated to 70 °C and added to Part B for emulsification and dispersion. It was cooled to about 40 °C and mixed uniformly.

[0122] Example 59 Sunscreen cosmetic Component Dosage (wt%) ---------------------------------- Part A Quaternium-18 Hectorite 1.0 Part B Cyclomethicone 13.7 Diphenyldimethylsilicone 2.0 Cyclopentasiloxane 10.0 Plandool-H (Nippon Seika) 1.0 Plandool-G (Nippon Seika) 0.5 Plandool-MAS (Nippon Seika) 2.0 Dicaprylyl Carbonate 1.0 Dimethicone Copolyol 5.5 Part C Silicone Treated Titanium Dioxide Fine Particles 3.9 Silicone Treated Zinc Oxide 2.1 Part D Aluminum Stearate 0.7 Aluminum Hydroxide 0.5 Isononyl Isononanoate 2.5 Diethyl Sebacate (Nippon Seika) 1.0 Neosolue-MP (Nippon Seika) 1.0 Neosolue-DE (Nippon Seika) 1.0 Part E Trimethylsiloxysilicic Acid 1.2 Stearyl Glycyrrhetinate 0.02 Sorbitan Sesquioleate 2.0 Tocopherol 0.02 Part F Phosphocholine (70% Aqueous Solution) 1.0 Glucose 0.5 Trehalose 0.5 Sodium Chloride 1.0 Methylparaben 0.15 Purified Water in an amount that totals 100 --------------------------------- (Preparation Method) Part A was added to part B and stirred. C was then added and dispersed using a roller mill. Part D was heated and melted and added to the mixture of parts A, B, and C, and then part E was added and the temperature was raised to about 70°C. Part F was heated and gradually emulsified into the mixture of parts A to E while stirring.

[0123] Example 60 Sunscreen Cosmetic Component Amount (% by weight) --------------------------------- Part A Phytocompo-PP (Nippon Fine Chemical) 1.0 1,3-butylene glycol 10.0 Glycerin 9.0 Part B Ethylhexyl methoxycinnamate 7.0 Diethylaminohydroxybenzoylhexyl benzoate 7.0 Behenyl Alcohol 4.0 Plandool-LG1 (Nippon Fine Chemical) 0.5 Plandool-MAS (Nippon Fine Chemical) 1.0 C part Phosphocholine (70% aqueous solution) 1.0 Methylparaben 0.15 Purified water (amount to make a total of 100) D part Xanthan gum 0.2 Sodium Hyaluronate 0.01 Purified water 10.0 --------------------------------- (Preparation method) Part A was dispersed uniformly. Parts B and C were each heated to approximately 70°C and dissolved. Part B was gradually added to Part A, and then Part C was gradually added and emulsified. The mixture was cooled with stirring, and at 45°C, parts D and E were added and mixed uniformly.

[0124] Example 61 Skin Care Oil Component Amount (% by weight) ----------------------------------- Part A Macadamia nut oil 24.0 Squalane 24.0 Neosolue-MCT (Nippon Seika) 10.0 Plandool-SUN (Nippon Seika) 2.0 Tocopherol 0.1 Part B Phosphocholine (70% aqueous solution) 0.5 Neosolue-AquaS (Nippon Seika) 0.5 NaCl 0.1 Methylparaben 0.1 Phenoxyethanol 0.4 Water in an amount to make 100 in total ----------------------------------- (Preparation method) Part A was heated to 50°C, uniformly dissolved, and cooled to room temperature. Part B was heated to 80°C, uniformly dissolved, and cooled to about 40°C. Part A and Part B were mixed.

[0125] Example 62 Oil-droplet dispersed lotion Ingredient Blending amount (wt%) ----------------------------------- Part A YOFCO CLC-678 (Nippon Seika) 1.0 Part B Gellan gum 0.1 Glycerin 2.0 1,3-Butylene glycol 5.0 Phosphocholine (70% aqueous solution) 1.0 Methylparaben 0.1 Phenoxyethanol 0.3 Water in an amount to make 100 in total ----------------------------------- (Preparation method) The B part was heated to about 80 °C and uniformly dissolved. The A part was added and cooled to about 40 °C while stirring.

[0126] In the above formulation, the details of the ingredients described by the product name are as follows. 〇Inulin-SC: Inulin 〇LP70H: Hydrogenated lysophosphatidylcholine 〇LUSPLAN DD-IS: Dimer dilinoleyl diisostearate 〇LUSPLAN PI-DA: Di(isostearyl / phytosteryl) dimer dilinoleate 〇LUSPLAN DD-DHR: Dimer dilinoleyl hydrogenated rosin condensate 〇LUSPLAN DD-DA7: Dimer dilinoleyl dimer dilinoleate 〇LUSPLAN SR-DM4: Dimer dilinoleyl dimer dilinoleate, glyceryl tri(caprylate / caprate) 〇Neosolue-Aqulio: Bis(ethoxydiglycol) cyclohexanedicarboxylate 〇Neosolue-AquaS: Polyglyceryl-10 (eicosanedioic acid / tetradecanedioic acid) 〇Neosolue-MCT: Glyceryl tri(caprylate / caprate) 〇Neosolue-MP: Methylpentaerythritol dineopentanoate 〇Neosolue-DE: Diethylpentaerythritol dineopentanoate 〇Plandool-ISS: Phytosteryl isostearate 〇Plandool-SUN: Phytosteryl sunflower seed oil fatty acid 〇Plandool-MAS: Phytosteryl macadamia nut oil fatty acid 〇Plandool-LG1: Di(phytosteryl / octyldodecyl / behenyl) lauroyl glutamate 〇Plandool-LG2: Di(phytosteryl / octyldodecyl) lauroyl glutamate Plandool-LG3: Phytosteryl / Octyldodecyl / Behenyl Lauroyl Glutamate Plandool-LG4: Phytosteryl / Octyldodecyl / Behenyl Lauroyl Glutamate Plandool-DP: Bis-diglyceryl polyacyladipate-2 Plandool-G: Dimer dilinoleyl bis(behenyl / isostearyl / phytosteryl) dimer dilinoleate Plandool-H: Dimer dilinoleic acid (phytosteryl / isostearyl / cetyl / stearyl / behenyl) Phytopresome MEL: glycolipids, hydrogenated lecithin, BG, purified water Phytocompo-PP: Hydrogenated lecithin, phytosterol Phytocompo-C: Hydrogenated lecithin, phytosterol, ceramide 2, ceramide 3, ceramide 6II Tremoist-TP: Tremella fuciformis polysaccharide Tremoist-SL: Tremella fuciformis polysaccharide 1% aqueous solution YOFCO CLC-678: Dihydrocholesteryl oleate, cholesteryl nonanoate, dihydrocholesteryl butyrate, cholesteryl butyrate, phytosteryl oleate Erucalactone DES: γ-docosalactone, diethyl sebacate Erucalactone MCT: γ-docosalactone, caprylic / capric triglyceride Cation NH: Quaternium-33

Claims

1. A cosmetic containing phosphocholine.

2. A cosmetic containing the following components (A) and (B). (A) Phosphocholine (B) A compound that forms a deep eutectic solvent with component (A)

3. The cosmetic according to claim 2, wherein component (B) is a compound that forms a deep eutectic solvent with component (A) and is selected from the following components (B1) to (B8). (B1) Polyhydric alcohols (B2) Sugars (B3) Organic acids (B4) Dibasic acids (B5) Aromatic alcohols or aromatic carboxylic acids (B6) Ascorbic acids (B7) Organic amines (B8) Organic amides

4. The cosmetic according to claim 3, wherein component (B) is component (B1), and component (B1) is one or more selected from ethylene glycol, propylene glycol, 1,3 - propanediol, 1,2 - butylene glycol, 1,3 - butylene glycol, 2,3 - butylene glycol, tetramethylene glycol, hexylene glycol, octylene glycol, 1,2 - pentanediol, 1,2 - hexanediol, 1,2 - heptanediol, 1,2 - octanediol, 1,2 - decanediol, glycerin, trimethylolpropane, 1,2,6 - hexanetriol, sorbitol, xylitol, erythritol, inositol, maltitol, mannitol, ethyl glycerin, butyl glycerin, hexyl glycerin, ethylhexyl glycerin, cyclohexyl glycerin, diethylene glycol, triethylene glycol, tetraethylene glycol, polyethylene glycol, dipropylene glycol, tripropylene glycol, polypropylene glycol, diglycerin, triglycerin, tetraglycerin, polyglycerin and isosorbide.

5. The cosmetic according to claim 3, wherein component (B) is component (B2), and component (B2) is one or more selected from xylose, galactose, glucose, mannose, fructose, maltose, trehalose, lactose, sucrose, glucosamine, N - acetylglucosamine, alkyl glucoside, glyceryl glucoside and arbutin.

6. The cosmetic according to claim 3, wherein component (B) is component (B3), and component (B3) is one or more selected from acetic acid, propionic acid, butyric acid, valeric acid, caproic acid, glycolic acid, lactic acid, malic acid, tartaric acid, citric acid, gluconic acid, levulinic acid, glutamic acid, aspartic acid, and phytic acid.

7. The cosmetic according to claim 3, wherein component (B) is component (B4), and component (B4) is one or more selected from oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, azelaic acid, sebacic acid, maleic acid, fumaric acid, and cyclohexanedicarboxylic acid.

8. The cosmetic according to claim 3, wherein component (B) is component (B5), and component (B5) is one or more selected from phenol, cresol, benzyl alcohol, phenethyl alcohol, phenoxyethanol, dibutylhydroxytoluene, butylhydroxyanisole, thymol, hinokitiol, isopropylmethylphenol, vanillin, propyl gallate, paraoxybenzoic acid ester, benzoic acid, salicylic acid, gallic acid, phthalic acid, caffeic acid, hydroxycaffeic acid, ferulic acid, and caffeic acid.

9. The cosmetic according to claim 3, wherein component (B) is component (B6), and component (B6) is one or more selected from ascorbic acid, ascorbic acid phosphate ester, ascorbic acid glucoside, ascorbic acid fatty acid ester, and ascorbic acid alkyl ether.

10. The cosmetic according to claim 3, wherein component (B) is component (B7), and component (B7) is one or more selected from monoethanolamine, diethanolamine, triethanolamine, lysine, arginine, histidine, ornithine, creatine, guanidine, and tris(hydroxymethyl)aminomethane.

11. The cosmetic according to claim 3, wherein component (B) is component (B8), and component (B8) is one or more selected from urea, dimethylurea, hydroxyethylurea, allantoin, and nicotinamide.

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