Medicine preparation support system and medicine preparation support program

Abstract

To provide a medicine preparation support system capable of adjusting a difference generated by excess or deficiency in an extraction amount.SOLUTION: A medicine preparation support system includes: an information processing device equipped with display control means for creating display data on preparation work contents including a medicine name, a stipulation amount, and a preparation amount based on preparation information; reading means for reading a recognition code for a supply container storing the medicine in preparation work; and measuring means for measuring the weight of the supply container. The preparation work contents include a plurality of extraction processes for measuring an extraction amount by extracting an injection medicine in a target amount by a manual inhalation device from the supply container and measuring the weight of the supply container before and after the extraction by the measuring means. When the preparation amount exceeds the target amount per supply container, the information processing device performs a re-calculation process for adjusting the target amount in a subsequent extraction process in accordance with the extraction amount by the extraction process later than the plurality of extraction processes.SELECTED DRAWING: Figure 1

Description

[Technical Field]

[0001] The present invention relates to a dispensing support system for supporting the preparation work of dispensing medicines based on prescription instructions and the pharmacists who perform that work, and more specifically, to a dispensing support system and dispensing support program that extends the scope of support beyond dispensing to administration work such as medication, and further to administering personnel such as doctors and nurses. [Background technology]

[0002] Manual dispensing work by humans is still the norm for mixed injection work, such as mixing injectable medications, and for dispensing work in small pharmacies. Several dispensing support systems have been proposed that reduce the burden on pharmacists through automation or semi-automation of dispensing work, which includes such manual tasks (see, for example, Patent Documents 1 and 2). Furthermore, when mixing anticancer drugs, which can sometimes involve handling hazardous substances, the amount of drug used is often adjusted individually to suit the patient's physique, resulting in a certain amount of residual liquid being left over after use. Alternatively, the required amount of drug may be extracted manually from multiple bottles, resulting in residual liquid being left over. While traditionally, such residual liquid was recommended for disposal, rising medical and disposal costs have led to the search for ways to reuse such residual liquid while taking safety into consideration in recent years. For example, in a fully automated co-infusion device, a method has been proposed in which the remaining liquid is retained within the device to efficiently use the remaining drug (see, for example, Patent Document 3, etc.). Furthermore, since the drug dispensing process often involves manual work as mentioned above, a method such as that described in Patent Document 4 has also been considered as a method for supporting the management of remaining drugs in a dispensing support system that involves manual work while taking safety into consideration.

[0003] In dispensing support systems that support dispensing work that involves such manual labor, when the required amount of the same drug is manually drawn from multiple containers into a syringe, support is generally provided, such as by displaying the required amount to the worker, but it is considered preferable that the actual amount drawn be measured using a balance (see, for example, Patent Document 2). Particularly in the case of manual work, the actual amount extracted may not exactly match the specified amount in the container due to accumulation of the liquid at the bottom of the container, foaming, etc. Alternatively, some pharmaceutical manufacturers are known to have containers that are designed to allow for a margin in the maximum amount that can be extracted from the container compared to the specified amount written on the drug container, so that the specified amount can be extracted even if some drug accumulates at the bottom of the container. However, when the actual amount of medicine filled is more than the specified amount, the amount is often within a specified tolerance range, such as ±10% or ±5%, but there is no uniform standard for the actual amount filled, and the maximum amount that can be inhaled varies depending on the dispensing staff's level of expertise and the shape of the tip of the manual inhaler. In other words, there are many cases where the amount of remaining medicine varies depending on the actual amount filled and the dispensing staff.

[0004] Therefore, even if an attempt is made to reuse this seemingly remaining residual liquid, conventional dispensing support systems have the problem that they only have information up to the specified amount, and drawing more than the specified amount is treated as an error.Alternatively, if there is a drug that contains more than the specified amount, for example, even if less than the specified amount is drawn from the first bottle, it is possible to draw the specified amount plus the surplus from the second and third bottles to make up the total amount, but there is no dispensing support system that takes such overfilled amounts into account and recalculates the total amount to be drawn from multiple containers, so any shortage is treated as an error. [Prior art documents] [Patent documents]

[0005] [Patent Document 1] Patent No. 5828832 [Patent Document 2] Patent No. 5743332 [Patent Document 3] Patent No. 5696822 [Patent Document 4] Japanese Patent Publication No. 2023-026916 Summary of the Invention [Problem to be solved by the invention]

[0006] The present invention is intended to solve the above technical problems, and aims to provide a dispensing support system that can adjust the difference caused by the amount of medicine extracted manually during the process. [Means for solving the problem]

[0007] In order to solve the above problems, the dispensing support system of the present invention provides a dispensing support system including: an information processing device including a drug master that stores information including drug names and prescribed amounts for various drugs as data; and display control means that obtains drug names and prescribed amounts from the drug master based on prescription information and creates display data related to dispensing work details of a dispensing person including the drug names, prescribed amounts, and prescribed amounts; display means that can display the display data visually to the dispensing person; reading means that reads an identification code of a supply container of the drug when dispensing work is performed using the drug; and measuring means that can measure the weight of the supply container containing the drug during the dispensing work. The system is characterized in that the dispensing work content includes a plurality of extraction steps in which a target amount of injection medicine is extracted from a supply container containing the medicine using a manual inhaler and the extracted amount is measured by measuring the weight of the supply container before and after extraction using the measuring means, and when the prescribed amount exceeds the target amount of the medicine per supply container, the information processing device executes a recalculation step, when a difference occurs between the extracted amount and the target amount in an earlier extraction step among the plurality of extraction steps, by a subsequent extraction step after the earlier extraction step, to vary the target amount in the later extraction step according to the extracted amount. [Effects of the Invention]

[0008] According to the dispensing support system of the present invention, the difference caused by the amount of medicine extracted manually can be recalculated midway, thereby enabling efficient use of medicines. [Brief explanation of the drawings]

[0009] [Figure 1] 1 is a diagram showing an example of the overall configuration of a dispensing support system according to an embodiment of the present invention. [Figure 2] 2 is a diagram illustrating an example of a functional configuration of a control unit of the dispensing support system shown in FIG. 1. FIG. [Figure 3] FIG. 2 is a diagram showing an example of the configuration of medicine containers and a tray for carrying them in the dispensing support system shown in FIG. 1. [Figure 4] FIG. 2 is a diagram showing an example of a series of operations for dispensing work in the dispensing support system. [Figure 5] FIG. 5 is a diagram showing an example of a series of operations in the preparation process in FIG. 4. [Figure 6] FIG. 10 is a diagram showing an example of a screen displayed by the dispensing support system. [Figure 7] FIG. 10 is a diagram showing an example of a screen displayed after ideal preparation processing has been performed by the dispensing support system. [Figure 8] FIG. 10 is a diagram showing an example of a display screen after the preparation process is completed. [Figure 9] 10A and 10B are diagrams showing an example of a part left behind due to the shapes of a syringe and a vial during preparation work. [Figure 10] FIG. 10 is a diagram showing an example of a confirmation operation on a display screen when recalculation is performed by the dispensing support system. [Figure 11] FIG. 10 is a diagram showing an example of a display screen after recalculation by the dispensing support system. [Figure 12] FIG. 10 is a diagram showing an example of a display screen after recalculation by the dispensing support system in the second or subsequent sampling process. [Figure 13] FIG. 8 is a diagram showing a schematic diagram in which a different preparation result was obtained with the same formulation as shown in FIG. 7. [Figure 14] FIG. 10 is a diagram showing an example of a display screen for a prescription prepared from a plurality of liquid medications according to a second embodiment of the present invention. [Figure 15] FIG. 10 is a diagram showing an example of a confirmation operation on a display screen when recalculation is performed by the dispensing support system. [Figure 16] FIG. 10 is a diagram showing an example of a display screen after recalculation by the dispensing support system in the second or subsequent sampling process. [Figure 17] FIG. 17 is a diagram showing an example of a display screen after recalculation when a difference different from that shown in FIG. 16 is found. DETAILED DESCRIPTION OF THE INVENTION

[0010] Hereinafter, embodiments of the present invention will be described with reference to the drawings. Fig. 1 shows a dispensing support system 10 as a first embodiment of the present invention. In the following explanatory diagrams, for the sake of simplicity, the illustrations focus on those necessary for explaining the invention and those related to it.

[0011] As shown in Fig. 1, the dispensing support system 10 includes a programmable information processing device 13, a reader 11 connected to the information processing device 13 by a signal cable or the like as input devices of the information processing device 13, an electronic scale 12, an operation input device 15, a prescription information input device 16, and a display device 14 connected to the information processing device 13 by a signal cable or the like as output devices of the information processing device 13, all of which are respectively provided on a dispensing table 4a or another dispensing table 4b. When there is no need to distinguish between the dispensing tables 4a and 4b, the dispensing tables 4a and 4b will be referred to as a dispensing table 4. In addition, in the pharmacy department of a typical hospital, an inspection table 5, which is a workbench for inspections, may be provided separately from the dispensing tables 4a and 4b. In this embodiment, we will first provide an example of assistance with dispensing work, in which a solid drug M is dissolved in saline using a manual inhaler 8 such as a syringe from a supply container 6 described below, and the required amount of dissolving liquid is extracted and mixed.

[0012] The information processing device 13 is an information processing unit that receives prescription information such as prescriptions from a higher-level system 200 such as an electronic medical record as shown in Figure 2, and is an information processing terminal that has programmable general-purpose hardware such as a personal computer and programs and data installed on the hardware. The information processing device 13 is connected to a reader 11 as a reading means for reading an identification code such as a barcode displayed on a supply container 6 such as an outer box of the medicine M. Furthermore, inside or outside the information processing device 13, a database 80 is provided as a medicine master database that can refer to information on medicines, and is connected to the information processing device 13 in a manner that allows two-way communication. The dispensing support system 10 also has an electronic scale 12 as a measuring means capable of measuring the weight of the supply container 6 containing the medication M during dispensing work.

[0013] The information processing device 13 has a display control means 40 that creates display data related to the dispensing work content of the dispensing technician, including the name of the drug M, the specified amount, the prescribed amount, etc., from the input prescription information, a target amount calculation means 50 that is a calculation means that receives the prescription data and calculates the target extraction value of the drug M to display on the display control means 40, and a remaining drug determination means 60 that manages the remaining amount of the drug M left in the supply container 6.

[0014] The operation input device 15 is a device for inputting desired information into the information processing device 13 by human operation, and in this embodiment is a foot pedal arranged below the dispensing table 4. By using the foot pedal in this manner, even when the preparer's hands are occupied at the dispensing table 4, the operation input device 15 can be operated with the foot. The operation input device 15 is not limited to this configuration, and may be an existing input device such as a mouse or keyboard that is operated by fingers. Furthermore, the operation input device 15 and the display device 14 may be integrated into one unit, and a touch panel system may be adopted that allows display and input operation at the same time.

[0015] The dispensing table 4 is a workbench on which the preparer performs a series of preparation tasks, including removing the medication M from the supply container 6 shown in Figure 3 and described below, mixing or dissolving the medication, and withdrawing the required amount of the dissolved solution using the manual inhaler 8. As long as the dispensing support system 10 can be installed and dispensing tasks can be performed, the dispensing table 4 may be a simple flat desk, a dispensing shelf with a work board, a standalone piece of equipment, or an equipment attached to other equipment. It is often installed in hospitals, but may also be installed elsewhere, and may be under atmospheric pressure or in a positive or negative pressure environment, either inside or outside a clean area such as a clean room, clean bench, or safety cabinet.

[0016] A reader 11 and an electronic scale 12 are placed on the work surface of the dispensing table 4, and a supply container 6 and a manual inhaler 8 are also placed thereon during dispensing work. In addition, a display device 14, which is an image projection device, is installed at a location on the dispensing table 4 that is easily visible to the dispensing staff, and an operation input device 15 is installed at a location on the dispensing table 4 that is easily operable by the dispensing staff. In this example, for the sake of explanation, the information processing device 13 is also installed on the dispensing table 4, but the information processing device 13 and prescription information input device 16, which are not directly perceived or operated by the pharmacist, may be installed in a location separate from the dispensing table 4, or may be connected to the information processing device 13 via a network. In addition, a plurality of dispensing tables 4 may be provided.

[0017] In this embodiment, the supply container 6 is a vial-shaped container, as shown in FIG. 3, which contains and holds in a sealed state the drug M, which is a freeze-dried drug. Typical examples of such supply containers 6 include vials, bottles, ampoules, and bags. Other examples of drug M include freeze-dried drugs and injections such as liquids, but also include diluents for diluting injections, tablets or powders that are liquefied before administration, solubilizers used for liquefaction, and infusion solutions made from physiological saline. When supporting dispensing operations involving drugs other than liquids, such as tablets or boxed drugs, the supply container 6 may not be sealed. Manual inhaler 8 is a device that can be manually operated to extract drug M or a liquid medication in which drug M is dissolved from supply container 6 and inhale it into the internal space, and typical examples include a syringe with an attached needle and a syringe without a needle. For handling medications other than liquid medications, a measuring cup or the like may also be used.

[0018] The electronic scale 12 is a precision electronic balance that can accurately measure the weight of the supply container 6 containing the drug M and the manual inhaler 8 that has inhaled the drug M, and is configured to transmit the measured weight, i.e., the weight value of the measurement result, to the information processing device 13 (see, for example, Patent Document 1).

[0019] The prescription information input device 16 consists of, for example, a wired LAN interface built into the information processing device 13 and / or a wireless communication device externally attached to the information processing device 13, and is configured to obtain the contents of the prescription instructions, i.e., prescription data (prescription information in electronic data of the prescription) and dispensing instruction data (prescription information to be supported), also described above, from a higher-level system 200 such as the external prescription acceptance device or prescription order entry system described above, and provide them for data processing by the information processing device 13. In addition, since such prescription information can be input into the information processing device 13 using the operation input device 15, the operation input device 15 may also be considered as a type of prescription information input device. The prescription information input device 16, the operation input device 15, the display device 14, and the information processing device 13, which will be described in detail below, may be integrated into any of the above devices, or may all be separate devices.

[0020] The reader 11 is a barcode reader capable of reading a regular code 70, which is an identification code shown in FIG. 3 and which is marked on a supply container 6 such as an outer box of a medicine, and is placed on the dispensing table 4, for example. The reader 11 is connected to the information processing device 13, and when it reads the authorized code 70, it can transmit identification information including the type and name of the corresponding drug M according to the code to the information processing device 13. The authorized code 70 may be, for example, a one-dimensional code such as a barcode, a two-dimensional code such as a QR code (registered trademark), a color code, or an appropriate code determined by each hospital.

[0021] In this embodiment, the display device 14 is a display means for visually displaying dispensing instruction information in an easily visible position in front of the preparer when he or she sits at the dispensing table 4, and is shown as an image projection device such as a projector. The information processing device 13 transmits the display data created by the display control means 40 to the display device 14, and the display device 14 sequentially displays the display data according to the procedure, for example, in accordance with the input of the preparer. By visually checking the display data while dispensing, the preparer can safely dispense the medicine while checking dispensing instruction information such as the actual prescribed amount of the medicine M and precautions.

[0022] A method for preparation using such a dispensing support system 10 will be described with reference to FIGS. In this embodiment, the display device 14 projects an image onto the wall surface at the back of the dispensing table 4, thereby displaying the preparation procedure, the medicines and saline solution used in the preparation, and their prescribed amounts.

[0023] First, prescription data (prescription information of electronic prescription data) and dispensing instruction data (prescription information to be supported) are input from the host system 200 to the information processing device 13 via the prescription information input device 16 (prescription information acquisition step S101).

[0024] These prescription data are also simultaneously sent to various devices other than the dispensing support system 10, and the preparer manually or automatically loads the prescribed drugs, including the drug M listed in the prescription data, onto the tray 100 (preparation step S102).

[0025] The upper system 200 manages the trays 100 by numbers such as patient numbers and tray numbers, or by RP (so-called prescription) units, and in the pre-preparation step, medications are prepared for each RP according to these numbers and the name and prescription amount of the corresponding medication M. At this time, the host system 200 may notify the preparer of the drugs to be prepared via the dispensing support system 10, or may transmit the prescription data to an external device such as a known automatic dispensing device so that the drugs are dispensed onto the tray 100. Alternatively, these means may be combined.

[0026] Once these advance preparation steps have been completed and the necessary medicines have been secured in tray 100, a pre-inspection is performed to check whether the necessary medicines are available in tray 100 (pre-inspection step S103). In the pre-audit step or an earlier stage, injectable drugs such as anticancer drugs are prepared in RP units and administration units according to the dispensing instruction data, and are placed in tray 100 together with a dispensing instruction sheet on which the dispensing instructions are printed.

[0027] After the pre-audit step, the preparer brings the tray 100 into a clean environment such as the aforementioned clean room or sterile room in accordance with the prescribed procedure, and selects the prescription information for the preparation work using the operation input device 15 (step S104). According to the prescription information selected in step S104, the dispensing support system 10 displays the dispensing instruction data on the display device 14 and proceeds with the preparation process.

[0028] In this embodiment, the preparation process is a series of processes including a plurality of steps performed by a preparer, and the specific content of the work will be described with reference to FIG. In this preparation process, the display device 14 displays the dispensing instruction data for the RP unit or the administration unit prepared in the previous audit step as selectable data, and the preparer uses the operation input device 15 to select the appropriate dispensing instruction data corresponding to the dispensing instruction sheet on the tray 100 while checking the dispensing instruction data. This selection may be made by having the reader 11 read the dispensing instruction sheet on the tray 100, or may be made by the preparer using the operation input device 15, for example. After making such a selection, the preparer takes out the prescribed medicine M from the tray 100 and causes the reader 11 to read the regular code 70 of the medicine M (step S105). Then, the display device 14 displays the dispensing instruction data for the drug M (Step S106). The following explanation will specifically exemplify a case where the prescription data specifies a prescription for 100 mL of saline and 250 mg of drug M, which has a specified amount of 100 mg, as shown in Figure 6. In this case, the dispensing instruction data instructs that a specified amount of 4.90 mL of saline, which is a dissolving agent, be injected into supply container 6 containing drug M, which is a lyophilized agent, to dissolve it, and that the entire amount of the dissolving agent, 4.9 mL (5.00 mg), be withdrawn into the syringe. In this embodiment, only a typical example in which the drug M is a freeze-dried drug will be described.

[0029] The preparer first places the supply container 6 of the drug M taken out from the tray 100 on the electronic scale 12 and measures its weight (step S107). Here, the specification data of the drug M handled by the dispensing support system 10, such as the drug capacity, is pre-registered in the drug master within the database 80, and the preparer can confirm from the specification data displayed on the display device 14 whether the drug M in the supply container 6 contains the specified amount required for the prescription. For example, in the examples of Figures 6 and 7, the specified amount per vial is 100 mg for an ordered amount of 250 mg of drug M, so it is displayed so that it can be understood that three vials of drug M are required. Furthermore, the preparation amount column displays two 1V vials, each representing one vial, and one 0.5V vial, representing 0.5 vials, for a total of three vials.

[0030] At the same time, the display device 14 displays as a target value the target amount of drug M to be extracted from the supply container 6. Here, the target value is shown as a target volume, a target weight, and a target amount of components, but it may be just one of the appropriate items. In this embodiment, the dispensing support system 10 calculates and displays the target volume and target weight from the data of the drug M stored in the database 80 based on the target component amounts.

[0031] The preparer performs the sampling work in accordance with a predetermined procedure based on the dispensing instruction data visually displayed by the display device 14 (sampling process step S108). Specific examples of the dispensing instruction data may be those described in, for example, Japanese Patent No. 5828832. For example, if the supply container 6 for the drug M is in the shape of a vial, the procedure may be displayed in order, such as a method for maintaining negative pressure when sampling from the vial to a syringe.

[0032] Electronic scale 12 measures the change in weight of supply container 6 before and after the preparation step. Information processing device 13 records the measured change in weight of supply container 6 as the amount taken out from supply container 6 (step S109). At this time, the display device 14 prompts the preparer to place the supply container 6 after extracting the target amount of extraction, for example, on the electronic scale 12. In this way, the preparation's extraction work is performed by the preparer, and the preparation's weight is measured before and after the extraction work by the dispensing support system 10. Even in such manual extraction work, the preparation is supported in an appropriate operation by displaying instructions from the dispensing support system 10.

[0033] When the preparer follows the instructions, extracts the injection medication from the supply container 6 using the manual inhaler 8 and places the supply container 6 on the electronic scale 12, the dispensing support system 10 measures the weight and determines whether it is within a predetermined range (e.g., ±5%) of the extraction target value calculated in step S107 (determination step S110). For example, in the preparation screen example shown in Figure 6, a target volume of 4.90 mL and a target weight of 5.00 g corresponding to a target component amount of 100 mg are displayed, and a result weight of 4.00 g and a result volume of 3.92 mL are displayed as the amount extracted as a record of the preparation result in the actual preparation step. Furthermore, the dispensing support system 10 further estimates the amount of drug M actually present in the medicinal solution from the extracted amount based on the concentration of the medicinal solution when the procedure is followed, and displays 80.00 mg as the component weight value of drug M contained in the medicinal solution. It is preferable that the dispensing support system 10 also records the preparer, preparation time, and preparation content. In addition, the dispensing support system 10 may be provided with a photographing unit such as a camera to record the preparation work as image data. In this way, the results of operations such as the sampling process carried out during preparation are recorded as the result volume, result weight, result component amount, etc. in the table shown in FIG.

[0034] If it is determined in step S110 from the change in weight measured in step S109 that the amount of drug M is within a predetermined range from the target extraction value, the dispensing support system 10 records the extracted amount of drug M and moves to the next preparation step, which is the extraction step of a second bottle of drug M. At this time, the dispensing support system 10 checks whether or not there are other drugs included in the prescription data (step S119), and ends the process when the preparation steps have been completed for all drugs. As already mentioned, the table of Fig. 6 initially displayed on the display device 14 lists three bottles of drug M for the prescribed amount of 250 mg to be extracted. Therefore, in this example, by repeating each of the steps S105 to S110 three times, the preparation work for all of the drug M is completed. When the ideal sampling process is performed for all three bottles, the sampling results for the three bottles of medicine M that fall within a predetermined range from the sampling target value are recorded, as shown in FIG.

[0035] The injection medication Mb thus prepared using the manual inhaler 8 is placed on a tray 100 together with the supply container 6 and brought to the final inspection table 5 located near the dispensing table 4 (step S120). As an example, the case where the final inspection is performed at the final inspection table 5 separate from the dispensing table 4 is described here, but the present invention is not limited to this configuration, and the inspection may be performed at the dispensing table 4 by a final inspector other than the preparer, or the inspection may be performed in a completely separate location.

[0036] In step S120, the final inspector determines whether the preparation record made in the preparation step for the injection drug Mb in the tray 100 matches the prescription data. Specifically, the dispensing support system 10 uses a display means such as the display device 14 or the monitor 17 to enable confirmation of the preparation results as shown in Figure 8, and enables reference to the preparer, preparation time, and preparation contents of the prepared injection drug Mb. The final auditor checks the preparer, preparation time, and preparation contents of the injection medication from the screen displayed on the monitor 17, which is a display means installed on the final inspection table 5, for example, and also checks the actual supply container 6 and manual inhaler 8 stored in the tray 100 to confirm that the prescribed order information and the preparation record match. If the final inspector determines that the preparation performed in the preparation step matches the prescription data, he or she records that the inspection was successful using the operation input device 15. Provided that such an operation has been performed, the information processing device 13 records the details of the final inspection (the inspector in charge and the time of the inspection). After the final inspector has completed the inspection, the injection drug Mb in the tray 100 is transported to a hospital ward or the like along with the tray 100.

[0037] Although an ideal sampling process would be carried out in this manner, in actual preparation work, there may be cases where the amount sampled is either too much or too little compared to the target amount. For example, as shown in Figure 9, there are cases where the medicinal liquid has accumulated in the shoulder part of the vial shape and cannot be removed, or when the medicinal liquid foams when dissolving the freeze-dried agent, and the foamy part of the medicinal liquid cannot be removed. If the drug solution cannot be completely removed, several countermeasures are known that the preparer may take, such as changing the size of the manual inhaler 8 or leaving it to stand until the bubbling subsides and then removing the drug M again. However, the use of extra equipment and the increased time required for preparation are undesirable, particularly in hospital pharmacies where large quantities of medicines are prepared.

[0038] Therefore, in this embodiment, if the sampling amount differs from the sampling target value in step S110, that is, if a difference of more than a predetermined value occurs, the sampling target value is recalculated in other sampling processes that handle the same drug M, so that the final injection drug Mb is prepared at the specified concentration and amount. Specifically, when the sampling amount is less than the sampling target value in the determination process of step S110, the dispensing support system 10 displays a selection screen for whether or not to perform recalculation together with a warning that the sampling amount is less than the sampling target value (step S111), as shown in Fig. 10. In this way, step S111 is a confirmation process for confirming whether or not to perform the recalculation process after completing the sampling process. In step S111, if "Yes" is selected to perform recalculation, the dispensing support system 10 recalculates the sampling target value for subsequent sampling processes based on the result of step S109 of the first sampling process in which the sampling amount fell short of the sampling target value (recalculation process step S112).

[0039] In step S112, if the amount extracted in the extraction of the first vial of drug M falls short of the extraction target value, the dispensing support system 10 recalculates the extraction target values for the subsequent extraction steps of the second and third vials of drug M to increase them by the shortfall. For example, as shown in FIG. 11, if the amount extracted in the first vial is 4.00 g, this is calculated as 0.8 V, and it can be calculated that the manual inhaler 8 contains 80.00 mg of drug M as an ingredient. Furthermore, since the second vial of drug M is one vial, or 1 V, and the extraction target value cannot be increased any further, the dispensing support system 10 changes the extraction target values for the third vial, which has a remainder of the initial preparation amount, from the initial 0.5 V and target weight of 2.50 g to 0.7 V and target weight of 3.50 g. Here, the target extraction value was calculated as a weight to match the amount measured by electronic scale 12, but dispensing support system 10 has the function of converting the weight value into a volume and displaying it to facilitate extraction using manual inhaler 8, so it is also possible to display the corresponding target extraction value as 3.43 ml, as shown in Figure 11. Similarly, changing the component weight from 50.00 mg to 70.00 mg has the same meaning as the process.

[0040] When the recalculation is performed in step S112, the dispensing support system 10 determines whether the result of the recalculation is within a predetermined range, i.e., within a range in which the aforementioned shortfall amount can be extracted in a subsequent extraction process (step S113). If it is determined in step S113 that the recalculation result is within a predetermined range, the dispensing support system 10 proceeds to step S119 to continue processing. However, as already mentioned, the dispensing support system 10 executes the recalculation step S112 if there is another subsequent sampling process that handles the same drug M. Therefore, in step S119, there will always be subsequent dispensings, and processing will continue for the second and third drugs.

[0041] Furthermore, a case where the amount extracted from the first tube is 4.00 g and the amount extracted from the second tube is also 4.00 g will be described. At this time, similarly to the first sampling process, a selection screen for whether or not to perform recalculation is displayed in step S111, and then recalculation is performed in step S112. In the second extraction process, i.e., the second preparation process loop, the only process that can be recalculated is the third one, so in the recalculation process in step S112, as shown in Figure 12, the extraction target value in the extraction process of the third drug M is further changed from the previous 0.7V and target weight of 3.50g to 0.9V and target weight of 4.50g.

[0042] In this way, when the sampling amount in an earlier sampling step among the multiple sampling steps included in the preparation work step is insufficient for the sampling target value, the dispensing support system 10 executes a recalculation step to recalculate and change the sampling target value in the later sampling step before the later sampling step is performed. Furthermore, in this recalculation process, if there is a chemical of the same type with a remainder or fraction in the same RP, the target sampling value is set so that the balance is balanced using the chemical with the remainder or fraction, so that preparation can be continued through this recalculation process without having to prepare spare chemicals, etc. in advance. This recalculation not only determines whether the value measured using the electronic scale 12 is acceptable or not based on a threshold value, but also enables preparation of an accurate amount while shortening the preparation time.

[0043] In step S113, in unusual cases such as when the actual extraction amount is significantly lower than the extraction target value for the first bottle, the recalculation may result in the extraction target value being greater than the specified amount of drug M. In this way, when the recalculation result falls outside the adjustable range due to changes in the extraction target values for the second and third bottles due to a significant shortage of the actual extraction amount or the like (No in step S113), the dispensing support system 10 may display an error screen indicating that the recalculation of drug M has failed (step S114) and interrupt the process. Even in such a case, the preparation can be continued by displaying a message on the screen and then having the preparer go and get a new spare drug M. According to this configuration, if it is determined in the recalculation process that the changed target amount cannot be extracted from the supply container 6, an error will be reported in that process, and since it becomes clear that the required target value cannot be met through recalculation, the preparation work can be carried out more efficiently.

[0044] In this embodiment, the first bottle is set to 1V, the second bottle to 1V, and the third bottle to 0.5V based on the contents of the selected prescription information, and so a case where there is a shortage is described. However, for example, if 0.5V is extracted from the first bottle, it is possible that too much will be extracted, resulting in an amount greater than the target value. In that case, in step S112, which is the recalculation process, the target sampling value for the second or third bottle can be displayed by subtracting the excess amount extracted due to the difference between the target sampling value for the first bottle and the sampling amount.

[0045] Finally, when the preparer completes the third extraction process, the dispensing support system 10 will be in a state where the amount extracted for each extraction process performed on the drug M has been calculated from the weight values measured by the electronic scale 12, as shown in Figure 13. If the prescribed amount of injection drug Mb obtained by these extraction steps matches the total value of the final extraction amount within a predetermined range (for example, within 5%), the dispensing support system 10 determines that the finished injection drug Mb has been prepared in the correct prescribed amount, completes the adjustment step, and proceeds to step S120.

[0046] In conventional automatic dispensing support devices, even if a deviation from the target value specified in the prescription occurred, it was often treated as an error or the device would automatically continue sampling until the correct target value was reached. However, the dispensing support system 10 of the present invention includes a step of recalculating the sampling target value for a subsequent sampling step when a single RP contains multiple identical drugs and the previous sampling step results in a surplus or deficiency relative to a preset sampling target value. By carrying out such control, even when preparation is carried out manually, it is possible to shorten the preparation time while still being able to prepare the correct amount.

[0047] When the audit is completed in step S120, the dispensing support system 10 completes the preparation and moves on to the next RP or prescription procedure, as described above.

[0048] Now, as a second embodiment of the present invention, as shown in FIG. 14, a case will be considered in which 200 mg of medicine N, which is a liquid medicine contained in ampoules each containing 100 mg, is prescribed. The dispensing support system 10 of the present invention functions as a system that supports shortening preparation time and preparing accurate amounts by recalculating the target extraction value for the freeze-dried drug described in the first embodiment, but when a liquid drug is used as in the second embodiment, the time-saving effect and amount adjustment effect of recalculation are even greater due to the tendency for liquid drugs to be overfilled.

[0049] First, the concept of overfilling will be explained. In liquid preparations, the amount of active ingredients contained in the liquid preparation is important, so the concentration and amount must be appropriately controlled as a product. On the other hand, with liquid medication, as already shown in FIG. 9, it may remain in the shoulder part of supply container 6, or the liquid medication inside supply container 6 may not be completely removed depending on the size of the syringe needle. To solve these problems, manufacturers of liquid medications sometimes fill supply container 6 with a specified amount of a prescribed concentration and then add a certain amount of excess so that the specified amount can be appropriately withdrawn with a syringe. This excess is called an overfill. While the specific ratio and quantity will naturally differ between manufacturers, for example, suppose that Drug N used in the second embodiment contains 120 mg of Drug N, which is an ampoule containing a specified amount of 100 mg plus an overfill of 20 mg. That is, depending on the type of medicine, there may be cases where the manual inhaler 9 can extract an amount of medicine that is greater than the specified amount and the extraction target value. Although the manufacturer knows the exact amount of such overfilled medicine, it is not publicly available information, making it difficult to utilize. However, the dispensing support system 10 of the present invention pre-registers the overfilled amount in the medicine master database 80, and when the recalculated target amount for sampling is equal to or greater than the specified amount but less than the overfilled amount, the system refers to the overfilled amount to determine whether sampling is possible.

[0050] Specific control will be described below in Figures 14 and 16, similarly to Figure 11. Note that, since the specific steps of the preparation process are the same as those in the first embodiment shown in Figure 5, the same parts are numbered the same and the description will be omitted as appropriate. First, as in the first embodiment, prescription data (prescription information of electronic data of prescription) and dispensing instruction data (prescription information to be supported) are input from the upper system 200 to the information processing device 13 via the prescription information input device 16 (prescription information acquisition step S101).

[0051] These prescription data are also simultaneously sent to various devices other than the dispensing support system 10, and the preparer manually or automatically places the prescribed drugs, including drug N listed in the prescription data, on the tray 100 (preparation step S102). Once the advance preparation step is completed and the necessary medicines are secured in tray 100, a pre-inspection is performed to check whether the necessary medicines are available in tray 100 (pre-inspection step S103). In the pre-audit step or an earlier stage, injectable drugs such as anticancer drugs are prepared in RP units and administration units according to the dispensing instruction data, and are placed in tray 100 together with a dispensing instruction sheet on which the dispensing instructions are printed. After the pre-audit step, the preparer brings the tray 100 into a clean environment such as the aforementioned clean room or sterile room in accordance with the prescribed procedure, and selects the prescription information for the preparation work using the operation input device 15 (step S104).

[0052] As in the first embodiment, in this preparation process, the display device 14 displays the dispensing instruction data for the RP unit or the administration unit prepared in the pre-audit step as selectable data, and the preparer uses the operation input device 15 to select the appropriate dispensing instruction data corresponding to the dispensing instruction sheet on the tray 100 while checking the dispensing instruction data. This selection may be made by having the reader 11 read the dispensing instruction sheet on the tray 100, or may be made by the preparer using the operation input device 15, for example. After making such a selection, the preparer takes out a predetermined drug N from the tray 100 and causes the reader 11 to read the regular code 70 of the drug N (step S105). Then, the dispensing instruction data for the drug N is displayed on the display device 14 (Step S106). In the following explanation, as shown in Figure 14, a specific example will be given in which the prescription data specifies a prescription for 100 mL of saline and 200 mg of drug N, which has a specified weight of 5 g and an ingredient amount of 100 mg per specified weight. The volume of drug N when the specified amount of 100 mg is extracted is assumed to be 20 mL. In this case, the dispensing instruction data specifies that the entire amount of drug N, 20 mL (specified amount of 100 mg), should be extracted from supply container 6, which contains liquid drug N, into manual inhaler 8.

[0053] The preparer places the supply container 6 of the drug N taken out from the tray 100 on the electronic scale 12 and measures its weight (step S107). At the same time, the display device 14 displays the target amount of drug N to be extracted from the supply container 6 as a target value. The preparer performs sampling work in accordance with a predetermined procedure based on the dispensing instruction data thus visually displayed on the display device 14 (sampling step S108).

[0054] Electronic scale 12 measures the change in weight of supply container 6 before and after the preparation step. Information processing device 13 records the measured change in weight of supply container 6 as the amount taken out from supply container 6 (step S109). At this time, the display device 14 prompts the preparer to place the supply container 6 after extracting the target amount of extraction onto the electronic scale 12, for example.

[0055] When the preparer follows the instructions, extracts the injection drug from the supply container 6 using the manual inhaler 8 and places the supply container 6 on the electronic scale 12, the dispensing support system 10 measures the weight and determines whether the measured value is within a predetermined range (e.g., ±5%) of the extraction target value calculated in step S107 (step S110). Thus, step S110 is a determination step for determining whether the amount extracted in the extraction step satisfies the target amount. In the second embodiment, as shown in Figure 16, a target volume of 20 mL and a target weight of 5.00 g corresponding to a target component amount of 100 mg are displayed, and a result weight of 6.00 g and a result volume of 24 mL as the amount extracted are displayed as a record of the preparation results in step S108, which is the actual extraction process. Furthermore, the dispensing support system 10 further estimates the component amount of drug N from the extracted amount based on the drug master information in the database 70, and displays 120.00 mg as the weight value of drug N contained in the medicinal liquid. As in the first embodiment, the dispensing support system 10 preferably records the preparer, preparation time, and preparation contents. In addition, the dispensing support system 10 may be provided with a photographing unit such as a camera to record the preparation work as image data.

[0056] In the second embodiment, a case will be described in which the amount of extraction is greater than the target extraction value in step S110. In this case, as in the first embodiment, the target extraction value is recalculated in other extraction processes that handle the same drug N, so that the final injection drug Nb is prepared at the specified concentration and amount. Specifically, when the sampling amount is greater than the sampling target value, the dispensing support system 10 issues a warning that the sampling amount is greater than the sampling target value, as shown in FIG. 15, and displays a selection screen for whether or not to perform recalculation (confirmation step S111). In step S111, if "Yes" is selected to perform recalculation, the dispensing support system 10 recalculates the sampling target value for subsequent sampling steps based on the result of step S109 of the first sampling step, in which the sampling amount was greater than the sampling target value (recalculation step S112).

[0057] In step S112, if the sampling amount in the sampling of the first bottle of drug N is greater than the sampling target value, the dispensing support system 10 recalculates the sampling target values in the subsequent sampling steps of the second and third bottles of drug N so as to reduce the sampling target values by the excess amount. In other words, step S112 is a recalculation step. As shown in Figure 16, if the amount of the first bottle extracted is 6.00 g, the dispensing support system 10 can calculate that the manual inhaler 8 contains 120.00 mg of drug N as an ingredient, which corresponds to 1.2 V. Furthermore, because the original amount of drug N extracted from the second bottle was 1 V and 5.0 g, the dispensing support system 10 changes the extraction target values for the second bottle from 1 V and a target weight of 5.0 g to 0.8 V and a target weight of 4.0 g. Note that the dispensing support system 10 has the function of converting and displaying weight values into volumes to facilitate extraction using the manual inhaler 8. Therefore, it is possible to display the corresponding extraction target value as 16.00 ml, as indicated by the diagonal lines in Figure 16. Similarly, changing the ingredient weight from 100.00 mg to 80.00 mg has the same meaning.

[0058] In this way, when a difference occurs between the sampling target value and the actual sampling amount in an earlier sampling step among multiple sampling steps, the dispensing support system 10 executes a recalculation step to change the sampling target value according to the sampling amount before the later sampling step of the same drug. With this configuration, even when the actual amount extracted is less than or equal to the target amount, the chemical can be used efficiently.

[0059] In step S113, in unusual cases, such as when the actual amount extracted is significantly lower (or higher) than the target amount for extraction for the first bottle, the recalculation may result in a larger target value for extraction even when the overfilled amount of drug N is taken into account. In this way, when the recalculation result falls outside the adjustable range due to changes in the target values for extraction for the second and third bottles due to a significantly lower (or higher) amount of the actual amount extracted, etc. (No in step S113), the dispensing support system 10 displays an error screen indicating that the recalculation of drug M has failed (step S114) and suspends processing. In this case, as in the first embodiment, the dispensing support system 10 can continue preparation by displaying a message on the screen and then having the preparer go and obtain a new spare drug M, so further explanation will be omitted. In particular, in such a case, it is also possible to notify the preparer of an error that the recalculation of the drug N has failed.

[0060] Finally, when the preparer has completed all the sampling steps and finished the preparation process, the dispensing support system 10 will have calculated the amount of each sampling step performed on drug N from the weight values measured by the electronic scale 12 before and after the sampling step. If the prescribed amount of injection drug Mb obtained by these extraction steps matches the total value of the final extraction amount within a predetermined range (for example, within 5%), the dispensing support system 10 determines that the finished injection drug Mb has been prepared in the correct prescribed amount, completes the adjustment step, and proceeds to step S120.

[0061] Furthermore, when liquid medication N is used as in the second embodiment, the amount of medication extracted the first time may be small, as shown in FIG. At this time, in addition to calculating the amount of ingredients for 1V from the specified amount, if the overfill amount is registered in advance in the database 80, the dispensing support system 10 may calculate the sampling target value in the recalculation process by taking into account the overfill amount in addition to the specified amount.

[0062] Specifically, if the amount extracted from the first bottle is 0.9V, or 90mg of components, the second bottle should not be able to extract any more than this amount because the initial extraction target is 1V, or the specified amount is 100mg. However, as in this embodiment, if the overfill amount is registered in advance in the database 80 and it is known that 1.2 vials of the ingredient can be extracted from one vial of drug N, then up to 1.2V can be extracted, taking into account the overfill amount, as shown in Figure 17. In such a case, the dispensing support system 10 recalculates the sampling target value in the recalculation step based on a value that takes into account the overfill amount instead of the specified amount. Note that, as a general term, the overfill amount refers to an amount that is filled by approximately 5 to 20% in addition to the specified amount, so the total amount filled in the supply container 6 is expressed as the "value that takes into account the overfill amount."

[0063] That is, as shown in Figure 17, even if the sampling target value exceeds the specified amount of 100 mg, if it is smaller than the component amount of 120 mg including the overfilled amount, it is not regarded as an error, but the sampling target value is recalculated taking into account the overfilled amount, and the results are displayed as the target component amount of 110 mg, target volume of 22 mL, and target weight of 5.5 g. In this way, when it is determined in step S113 whether the sampling target value recalculated in step S112 is within the predetermined range, the determination is made taking into account the overfill amount.

[0064] According to this configuration, even when the actual amount extracted is less than or equal to the target amount, the chemical can be used efficiently.

[0065] In step S120 of the inspection process, the final inspector may use remaining medicine determination means 60 to perform remaining medicine registration processing for any remaining medicines that were used in the preparation processing step and still contain medicines. Explanation of the registration of such remaining medicines will be omitted.

[0066] <1> As described above, the dispensing support system 10 in this embodiment includes: a database 80 that stores information including drug names and prescribed amounts for various drugs; an information processing device 16 that includes display control means that obtains the drug name and prescribed amount from the database 80 based on prescription information and creates display data related to the dispensing work content of the dispensing person including the drug name, prescribed amount, and prescribed amount; a display means 14 that can display the display data visually to the dispensing person; a reading means that reads the recognition code 70 of the drug supply container 6 when dispensing work is performed using the drug; and an electronic scale 12 that can measure the weight of the supply container 6 containing the drug during dispensing work. Furthermore, the dispensing support system 10 is characterized in that the dispensing work content includes multiple extraction steps in which a target amount of injection medicine is extracted from a supply container 6 containing the medicine using a manual inhaler 8 and the extracted amount is measured by measuring the weight of the supply container 6 before and after extraction using an electronic scale 12, and when the prescribed amount exceeds the target amount per drug supply container, the information processing device 16 executes a recalculation step, by a subsequent extraction step among the multiple extraction steps, to vary the target amount in the subsequent extraction step according to the extracted amount, when the extracted amount in an earlier extraction step is either too much or too little compared to the target amount. According to this configuration, even when the actual amount extracted is less than or equal to the target amount, the chemical can be used efficiently.

[0067] <2> Furthermore, the dispensing support system 10 in this embodiment includes: <1> In addition to the configuration described above, the database 80 can store information on the overfill amount actually filled in the supply container 6 in addition to the drug name and specified amount, and when the target amount in the subsequent sampling step is changed in the recalculation step to match the sampling amount in the previous sampling step, the target amount is calculated based on the overfill amount. According to this configuration, even when the actual amount extracted is less than or equal to the target amount, the chemical can be used efficiently.

[0068] <3> Furthermore, the dispensing support system 10 in this embodiment includes: <1> , <2> In addition to the configuration described above, when the information processing device determines that the changed target amount cannot be extracted from the supply container 6 in the recalculation step, it notifies an error in that step. According to this configuration, if the required amount of medication cannot be extracted even after recalculation, the preparer is notified, thereby enabling the correct amount of injection medication to be prepared.

[0069] <4> In addition, the dispensing support system 10 in this embodiment includes: <1> ~ <3> In addition to the above, the target amount recalculated in the recalculation step is applied to the latest sampling step among the plurality of sampling steps. According to this configuration, the sampling target values can be readjusted all at once in the final sampling process, so that the sampling target values do not need to be repeatedly recalculated, and a high-speed dispensing support system 10 can be provided.

[0070] <5> Furthermore, the dispensing support system 10 in this embodiment includes: <1> ~ <4> In addition to the configuration described in any one of the above, the display control means executes a confirmation step of confirming whether or not the recalculation step is to be performed when the sampling step is completed. According to this configuration, recalculation can be performed only when the dispensing staff determines that such recalculation is necessary, thereby reducing the calculation load and providing a high-speed dispensing support system 10.

[0071] <6> Furthermore, the program introduced into the dispensing support system 10 in this embodiment is a dispensing support program executed on an information processing device that includes a database 80 that stores information including drug names and specified amounts for various drugs as data, and a display control means that obtains the drug names and specified amounts from the database 80 based on prescription information and creates display data related to the dispensing work content of the dispensing staff member, including the drug names, specified amounts, and prescribed amounts. The program causes the information processing device to execute at least a plurality of extraction steps as the dispensing work content, in which a target amount of injection drug is extracted using a manual inhaler from a supply container containing the drug and the extracted amount is measured by measuring the weight of the supply container before and after extraction; a determination step that determines whether the extracted amount is more or less than the target amount in the extraction step; and a recalculation step that, when it is determined in the determination step that the amount is more or less than the target amount, varies the target amount according to the extracted amount by the time of the next extraction step that is executed after the relevant extraction step among the plurality of extraction steps. With this configuration, even when the amount actually extracted by the dispensing technician is more or less than the target amount, the dispensing support system 10 can provide support for efficient use of medicines.

[0072] Although the preferred embodiment of the present invention has been described above, the present invention is not limited to such a specific embodiment, and unless otherwise specifically limited in the above description, various modifications and changes are possible within the spirit and scope of the present invention as set forth in the claims.

[0073] For example, in this embodiment, an embodiment of a system in which a reader 11, an electronic scale 12, an information processing device 13, a display device 14, etc. are connected is shown as the dispensing support system 10, but for example, these systems may be executed by a program that executes each of the means described above in steps S101 to S120 or by various storage media on which the program is stored. Furthermore, the terminals and devices for executing these functions may be installed in separate locations and connected to each other via a network.

[0074] The effects described in the embodiments of the present invention are merely a list of the most favorable effects resulting from the present invention, and the effects of the present invention are not limited to those described in the embodiments of the present invention. [Explanation of symbols]

[0075] 6…Supply container 8...Manual inhaler (syringe) 10...Pharmacy support system 11...Reading means 12…Measurement means 13...Information processing device 14...Display means 40...Display control means 60…Method for determining remaining medicines 70...Regular code 80...Drug master (database) S108…Sampling process S110…Judgment process S111…Confirmation process S112…Recalculation process

Claims

1. A medicine master that stores information including the names and prescribed amounts of various medicines as data; an information processing device including a display control means for determining a drug name and a prescribed amount from the drug master based on prescription information, and for creating display data relating to the dispensing work content of a dispensing person, including the drug name, the prescribed amount, and the prescribed amount; a display means for visually displaying the display data to the pharmacist; a reading means for reading the identification code of the drug supply container when performing a dispensing operation using the drug; a measuring means for measuring the weight of the supply container containing the medicine during the preparation work, a dispensing support system characterized in that the dispensing work content includes a plurality of sampling steps in which a target amount of injection medicine is extracted from a supply container containing the medicine using a manual inhaler and the extracted amount is measured by measuring the weight of the supply container before and after extraction using the measuring means, and when the prescribed amount exceeds the target amount of the medicine per supply container, the information processing device executes a recalculation step, by a subsequent sampling step among the plurality of sampling steps, to change the target amount in the subsequent sampling step according to the extracted amount when a difference occurs between the extracted amount and the target amount in an earlier sampling step among the plurality of sampling steps.

2. The dispensing support system according to claim 1, The medicine master can store information on the overfill amount actually filled in the supply container in addition to the medicine name and the specified amount, When the target amount in the subsequent sampling step is varied in the recalculation step to match the sampling amount in the previous sampling step, the target amount is calculated based on the overfill amount.

3. The dispensing support system according to claim 1, When the information processing device determines that the changed target amount cannot be extracted from the supply container in the recalculation step, the information processing device notifies an error in the recalculation step.

4. The dispensing support system according to claim 1, The dispensing support system is characterized in that the target amount recalculated in the recalculation step is applied to the sampling step performed most recently among the plurality of sampling steps.

5. The dispensing support system according to claim 1, The dispensing support system is characterized in that the display control means executes a confirmation step of whether or not to perform the recalculation step after completing the sampling step.

6. A medicine master that stores information including the names and prescribed amounts of various medicines as data; a display control means for obtaining a drug name and a prescribed amount from the drug master based on prescription information, and for creating display data relating to a dispensing operation content of a dispensing person, the display control means including the drug name, the prescribed amount, and the prescribed amount, The dispensing work includes at least a plurality of steps of extracting a target amount of injection medicine from a supply container containing the medicine using a manual inhaler and measuring the amount extracted by measuring the weight of the supply container before and after extraction; a determination step of determining whether the amount of the sampled product satisfies the target amount in the sampling step; a recalculation step of varying the target amount in accordance with the sampling amount until a sampling step to be executed after the sampling step among the plurality of times when an excess or deficiency is determined in the determination step; A dispensing support program characterized by executing the following.

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