Sensor unit and measuring instrument

Abstract

To provide a measurement system configured to comprise a sensor unit and a measuring instrument separately, improving reproducibility of a measurement result by stabilizing sensor sensitivity.SOLUTION: A sensor unit configured to be attachable / detachable with respect to a measuring instrument for executing electrochemical measurement, comprises a first cell for temporarily storing a test liquid supplied from the outside, and a second cell including a sensor electrode, where the sensor unit is so configured that the supply of the test liquid from the inside of the first cell to the inside of the second cell is triggered by attachment of the sensor unit to the measuring instrument.SELECTED DRAWING: Figure 1

Description

[Technical Field]

[0001] The present invention relates to a sensor unit and a measuring instrument. [Background technology]

[0002] There is known a measurement system that performs a voltage sweep operation on a sensor electrode that is in contact with a test liquid such as a body fluid to cause a predetermined reaction and measure the concentration of a specific component contained in the liquid. In particular, in recent years, with the aim of improving convenience, research and development has been progressing on a system in which a sensor unit equipped with a sensor electrode and a measuring device that applies a voltage (sweep, etc.) to the sensor electrode are separately configured (see, for example, Patent Document 1 and Patent Document 2).

[0003] This separate system offers various advantages to users, such as excellent handling due to the sensor unit being detachable from the measuring device, easy replacement and disposal of the sensor unit, the potential for cost reduction of the sensor unit through mass production, and the ability to share the measuring device among multiple people. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] Japanese Patent Application Publication No. 2019-12056 [Patent Document 2] Japanese Patent Application Publication No. 2022-32479 Summary of the Invention [Problem to be solved by the invention]

[0005] However, in the above-described system, measurement by the measuring instrument does not necessarily begin immediately after contacting the sensor unit with the sample liquid. After contacting the sensor unit with the sample liquid, the sensor unit may be left unattended for, for example, several minutes to several hours before measurement by the measuring instrument. If the sensor electrode is left unattended with the sample liquid attached, components in the sample liquid (e.g., proteins) may adhere to the active surface of the sensor electrode, causing significant fluctuations in sensor sensitivity. Furthermore, the amount of sensitivity fluctuation may vary significantly depending on the time the sensor is left unattended, environmental conditions, and other factors. For these reasons, stabilizing sensor sensitivity and improving the reproducibility of measurement results have become newly apparent challenges in the above-described separate-type measurement system.

[0006] The present invention has been made in consideration of the above-mentioned problems, and aims to provide a technology that stabilizes sensor sensitivity and improves the reproducibility of measurement results in a measurement system in which a sensor unit equipped with a sensor electrode and a measuring instrument that performs electrochemical measurements on the sensor unit are separately configured. [Means for solving the problem]

[0007] One aspect of the present invention is A sensor unit configured to be detachable from a measuring device for performing electrochemical measurements, a first cell for temporarily storing a test liquid supplied from the outside; a second cell containing a sensor electrode; The sensor unit is configured so that supply of the test liquid from the first cell to the second cell is triggered by attachment of the sensor unit to the measuring device. [Effects of the Invention]

[0008] According to the present invention, in a measurement system in which a sensor unit and a measuring instrument that performs electrochemical measurements on this sensor unit are configured separately, it is possible to stabilize sensor sensitivity and improve the reproducibility of measurement results. [Brief explanation of the drawings]

[0009] [Figure 1] FIG. 1(a) is a schematic diagram showing the configuration of a measurement system according to one embodiment of the present invention, and (b) is a schematic diagram for explaining attachment and detachment of a sensor unit. [Figure 2] FIG. 2(a) is a top view showing the configuration of a sensor unit according to one embodiment of the present invention, and (b) is a cross-sectional view thereof. [Figure 3] FIG. 3(a) is a diagram showing the sensor unit of FIG. 2(a) when a test liquid is stored therein, and (b) is a diagram showing the sensor unit when attached to a measuring device. [Figure 4] FIG. 4(a) is a diagram showing a sensor unit according to another embodiment of the present invention when a test liquid is stored in the sensor unit, and (b) is a diagram showing the sensor unit when attached to a measuring device. [Figure 5] FIG. 5(a) is a diagram showing a sensor unit according to another embodiment of the present invention when a test liquid is stored in the sensor unit, and (b) is a diagram showing the sensor unit when attached to a measuring device. [Figure 6] FIG. 6(a) is a diagram showing a sensor unit according to another embodiment of the present invention when a test liquid is stored in the sensor unit, and (b) is a diagram showing the sensor unit when attached to a measuring device. [Figure 7] FIG. 7(a) is a diagram showing a state in which a test liquid is stored in a sensor unit according to another embodiment of the present invention, and (b) is a diagram showing a state in which the sensor unit is attached to a measuring device. [Figure 8] FIG. 8 is a diagram showing a state in which a test liquid is stored in a sensor unit according to another embodiment of the present invention. [Figure 9] FIG. 9 is a diagram showing a state in which a test liquid is stored in a sensor unit according to another embodiment of the present invention. [Figure 10] FIG. 10 is a diagram showing a state in which a test liquid is stored in a sensor unit according to another embodiment of the present invention. [Figure 11] FIG. 11 is a perspective view showing the configuration of a sensor unit according to another embodiment of the present invention. [Figure 12]FIG. 12 is a schematic diagram for explaining the case where the measurement system is installed in a toilet. DETAILED DESCRIPTION OF THE INVENTION

[0010] <One embodiment of the present invention> An embodiment of the present invention will now be described, with a measurement system, a sensor unit, and a measuring device according to the present embodiment being described below.

[0011] (1) System configuration 1(a), the measurement system 1 of this embodiment includes a sensor unit 100, a measuring device 200, and a judgment support device 300. The measurement system 1 is configured to measure the concentrations of various components (specific substances, test substances) contained in the test liquid and to output judgment result data suggesting the health condition of the test subject based on the results.

[0012] The test liquid is not particularly limited, and examples thereof include various body fluids such as urine, saliva, sputum, nasal discharge, tears, sweat, blood, etc. When the test liquid is urine, examples of the specific substance include urea, ammonia, creatinine, uric acid, amino acids, ascorbic acid, phosphorus, oxalic acid, nitrite, sodium, potassium, calcium, protein, urinary sugar, ketone bodies, bilirubin, urobilinogen, cytokines, cortisol, red blood cells, white blood cells, platelets, etc.

[0013] (sensor unit) As shown in FIG. 1(b), the sensor unit 100 is portable enough to be carried by the subject's hand, and is detachable from the measuring device 200. As will be described later, when the sensor unit 100 is detached from the measuring device 200 and a test liquid is poured through the sensor unit 100, the sensor unit 100 is configured to isolate the test liquid from the sensor electrode 40 while retaining the test liquid. On the other hand, when the sensor unit 100 is attached to the measuring device 200, the attachment triggers contact between the test liquid and the sensor electrode 40. In this specification, a structure in which contact between the test liquid and the sensor electrode 40 occurs when the sensor unit 100 is attached to the measuring device 200 is referred to as a trigger structure.

[0014] The sensor unit 100 will now be described in detail with reference to Figures 2 and 3. Here, a case where the sensor unit 100 includes a vent pipe 60 as a trigger mechanism will be described as an example. Figure 2(a) is a top view showing the schematic configuration of a sensor unit according to one embodiment, and Figure 2(b) is a cross-sectional view thereof. Figure 3(a) is a diagram showing the sensor unit in a detached state when a test liquid is poured onto it, and Figure 3(b) is a diagram showing the sensor unit attached to a measuring device.

[0015] 2(a), the sensor unit 100 is mainly configured to include a substrate 10, a first cell 20 provided on one main surface of the substrate 10, a second cell 30, a sensor electrode 40 contained in the second cell 30, a flow path 50 that connects the inside of the first cell 20 with the inside of the second cell 30, and a vent pipe 60 that is connected to the second cell 30 and acts as a trigger structure. Although FIG. 2(a) shows a case where the first cell 20, the second cell 30, the flow path 50, the vent pipe 60, etc. are provided on the same main surface, they may also be provided on different main surfaces.

[0016] The substrate 10 is configured to support the first cell 20, the second cell 30, the sensor electrode 40, the flow path 50, and the vent pipe 60 on one of its two main surfaces. The substrate 10 is made of a sheet-like or plate-like member and is formed into a longitudinal shape.

[0017] The substrate 10 has a physical (mechanical) strength sufficient for use as the sensor unit 100, i.e., a strength sufficient to prevent bending or breakage even when a test liquid (urine) adheres to the substrate 10. The substrate 10 is made of an insulating material. Examples of insulating materials that can be used include plastic, glass epoxy resin, ceramic, and glass. The substrate 10 can be, for example, a rigid substrate or a flexible substrate.

[0018] The size of the substrate 10 is not particularly limited, but its length can be, for example, 20 mm or more and 115 mm or less, and its width can be, for example, 6 mm or more and 30 mm or less.

[0019] A first cell 20 for storing a test liquid is provided on one end of the main surface of the substrate 10. The first cell 20 is made of a water-resistant, insulating material such as plastic, and is configured as a hollow cylinder with a rectangular cross section. The internal space of the first cell 20 serves as the space for storing the test liquid. An inlet 21 is provided in the first cell 20. This inlet 21 is large enough to take in the test liquid, and serves as the opening for taking in the test liquid into the internal space when the test liquid is poured into the first cell 20.

[0020] A second cell 30 is provided on the main surface of the substrate 10, spaced apart from the first cell 20. The second cell 30 contains a sensor electrode 40. The second cell 30 is configured to inhibit the inflow of test liquid when detached from the measuring device 200, but to allow the test liquid to flow into it when attached to the measuring device 200. The internal space of the second cell 30 stores the test liquid flowing in from the first cell 20, and serves as a space where an electrochemical reaction occurs upon contact between the sensor electrode 40 and the test liquid. Like the first cell 20, the second cell 30 is made of a water-resistant, insulating material such as plastic, and is configured as a hollow cylinder with a rectangular cross section so as to be able to contain the sensor electrode 40.

[0021] From the viewpoint of ensuring that the test liquid contacts the sensor electrode 40 in the second cell 30 more reliably, it is preferable that the volume of the second cell 30 be smaller than the volume of the first cell 20 .

[0022] A flow path 50 is provided between the first cell 20 and the second cell 30 to communicate these spaces. The flow path 50 is configured to allow the test liquid to flow from the first cell 20 to the second cell 30 using a trigger structure. The flow path 50 is not particularly limited as long as it can carry the test liquid, and a plastic pipe, for example, can be used. As shown in FIG. 3(a), the flow path 50 is positioned so that the opening on the first cell 20 side is immersed in the test liquid S stored in the first cell 20.

[0023] From the viewpoint of causing the test liquid S to flow into the second cell 30 by capillary action, it is preferable that the flow path 50 has a shape that causes capillary action. For example, the inner diameter of the flow path 50 is preferably small enough to cause capillary action, and specifically, it is preferably 1 mm or more and 10 mm or less. Furthermore, it is preferable that the length of the flow path 50 is long enough to pump the test liquid from the first cell 20 to the second cell 30 by capillary action, and specifically, it is preferably 3 mm or more and 20 mm or less.

[0024] The sensor electrode 40, which generates an electrochemical reaction upon contact with the test solution S, is contained in the second cell 30. The sensor electrode 40 can be, for example, a working electrode, a counter electrode, or a reference electrode. The material of the working electrode can be selected appropriately depending on the type of specific component to be measured. The working electrode can be, for example, an electrode made of silver (Ag), Au, platinum (Pt), or Cu, a carbon electrode, or a conductive diamond electrode doped with boron (B). A functional film containing an enzyme or antibody that promotes the electrochemical reaction may be immobilized on the surface of the working electrode. The counter electrode is not particularly limited as long as it is a conductive electrode, and the same material as the working electrode can be used. The reference electrode can be, for example, a silver / silver chloride (Ag / AgCl) electrode. The sensor electrode 40 is not limited to the three-electrode type shown in FIG. 2(a) but may be a two-electrode type, for example, a working electrode and a counter electrode that also serves as a reference electrode.

[0025] Wiring 41 is connected to sensor electrode 40. Wiring 41 is arranged to connect to connection terminal 42 provided on the opposite side of sensor unit 100 from first cell 20. Sensor unit 100 can be electrically connected by inserting the side of connection terminal 42 into an insertion opening of measuring device 200, for example.

[0026] The wiring 41 can be formed using a metal such as copper (Cu) or aluminum (Al). The wiring 41 can be formed, for example, using a subtractive method in which unnecessary portions of a copper film previously applied to the substrate 10 that are not covered with resist are removed by etching to form a required conductor pattern. Furthermore, these conductor patterns formed using the subtractive method may be plated with, for example, gold (Au) or silver (Ag). Furthermore, for example, the wiring 41 can also be formed by screen printing, in which case silver or carbon-based wiring can be formed.

[0027] (measuring instrument) The measuring device 200 is configured to be connectable to the sensor unit 100 and is configured to measure an electrochemical reaction occurring when the sensor electrode 40 contacts the test liquid S using the sensor unit 100. For example, the measuring device 200 is configured to perform a predetermined voltage sweep scan or the like on the sensor electrode 40 to electrolyze a specific component contained in the test liquid, and measure the concentration of the specific component from the magnitude of the reaction that occurs during this process. Furthermore, the measuring device 200 is configured to measure the concentration of the specific component from the amount of voltage fluctuation (electromotive force) or current fluctuation that occurs due to the electrochemical reaction on the surface of the sensor electrode 40. In this embodiment, as shown in FIG. 3(b), the measuring device 200 has an insertion port for the sensor unit 100 and includes a needle-shaped member 210 positioned so that the vent tube 60 will break when the sensor unit 100 is inserted.

[0028] Preferably, the measuring device 200 is configured so that the start of electrochemical measurement is triggered by the attachment of the sensor unit to the measuring device. This allows the electrochemical reaction occurring due to contact between the test liquid S and the sensor electrode 40 to be promptly measured as soon as the test liquid S begins to flow from the first cell 20 into the second cell 30. As a result, fluctuations in sensor sensitivity can be avoided, and the reproducibility of measurement results can be improved.

[0029] Preferably, the measuring device 200 is configured to start electrochemical measurement after a predetermined time has elapsed after the sensor unit 100 is attached to the measuring device 200. After the sensor unit 100 is attached, the test liquid S begins to flow into the second cell 30, and after a predetermined time has elapsed, the second cell 30 is filled with a predetermined amount of test liquid S, and the flow of the test liquid S reaches a steady state. By performing electrochemical measurement in this state, the reproducibility of the measurement results can be further improved.

[0030] Furthermore, the measuring device 200 is configured to be able to transmit data indicating the concentration of the specific component obtained by the above-mentioned measurement to the judgment support device 300 via wireless communication means, wired communication means, or the like.

[0031] (Judgment support device) The judgment support device 300 is configured as a computer (smartphone, tablet, PC, etc.) equipped with a CPU, RAM, storage, output function, communication function, etc. The judgment support device 300 is configured to be able to output judgment result data suggesting the health condition of the subject to the subject or another information processing device based on concentration data received at a predetermined timing.

[0032] (2)Measurement method Next, the measurement method using the above-mentioned measurement system 1 will be explained using Figure 12. Figure 12 is a schematic diagram showing a measurement system for a test liquid in a toilet. Figure 12 illustrates an example in which the measurement device 200 and the judgment support device 300 are installed on the wall 400a of the toilet 400.

[0033] First, the subject prepares the sensor unit 100. For example, the subject brings the sensor unit 100 into the toilet 400, or picks up the sensor unit 100 installed in the toilet 400. Next, the subject holds the connection terminal 42 side of the sensor unit 100 at the toilet bowl 410, as shown in FIG. 2(a) or 2(b), and pours the test liquid S (e.g., urine) into the first cell 20. As a result, the test liquid S flows into the first cell 20 through the inlet 21, as shown in FIG. 3(a). At this stage, the vent pipe 60 is not opened, and the second cell 30 is airtight. Therefore, the test liquid S does not flow into the second cell 30, but remains in the first cell 20. The subject continues pouring the test liquid S until a predetermined amount of the test liquid S is stored in the first cell 20.

[0034] Next, after a predetermined amount of test liquid S has accumulated in the first cell 20, the subject inserts the sensor unit 100, with its connection terminal 42 side, into the insertion opening of the meter 200 and attaches it to the meter 200. At this time, as shown in FIG. 3(b), structural interference between the sensor unit 100 and the needle-shaped member 210 of the meter 200 causes one end of the vent tube 60 to break and open. This releases the airtight state of the vent tube 60, allowing the atmosphere in the second cell 30 to escape to the outside. As a result, the test liquid S accumulated in the first cell 20 flows into the second cell 30 via the flow path 50 due to capillary action. In the second cell 30, the test liquid S comes into contact with the sensor electrode 40, causing an electrochemical reaction.

[0035] On the other hand, the measuring device 200 performs a predetermined voltage sweep scan or the like on the sensor electrode 40 to electrolyze a specific component contained in the test liquid S, and measures the concentration of the specific component from the magnitude of the reaction that occurs at that time.

[0036] Based on the measurement data from the measuring device 200, the judgment support device 300 outputs judgment result data suggesting the health condition of the subject.

[0037] As described above, the subject can obtain measurement results using sensor unit 100 in toilet 400.

[0038] (3) Effects of this embodiment According to this embodiment, one or more of the following effects are achieved.

[0039] (a) The sensor unit 100 of this embodiment is constructed separately from the measuring device 200, and before being attached to the measuring device 200, when the test liquid S is applied, the test liquid S flows into the first cell 20 and is stored therein, but the test liquid S does not flow into the second cell 30 containing the sensor electrode 40. This makes it possible to temporarily prevent contact between the collected test liquid S and the sensor electrode 40. Therefore, even if time passes between the time the test liquid S is collected and the time it is used for measurement, it is possible to prevent components contained in the test liquid S from adhering to the sensor electrode 40, which would cause fluctuations in sensor sensitivity. The sensor unit 100 also includes a flow path 50 that connects the first cell 20 and the second cell 30, and a vent tube 60 that is connected to the second cell 30 and that allows the atmosphere in the second cell 30 to escape to the outside. The vent tube 60 is configured to open due to structural interference between components of the sensor unit 100 and components of the measuring device 200 when the sensor unit 100 is attached to the measuring device 200. Specifically, when the sensor unit 100 is attached to the measuring device 200, the end of the vent tube 60, which is a component of the sensor unit 100, is broken by a needle-shaped member 210, which is a component of the measuring device 200, thereby opening the vent tube 60. With the opening of the vent tube 60, the test liquid S stored in the first cell 20 can flow into the second cell 30 via the flow path 50 due to capillary action. In other words, the attachment to the measuring device 200 triggers the supply of the test liquid S into the second cell 30. As a result, the test liquid S and the sensor electrode 40 can be brought into contact with each other in the second cell 30, allowing an electrochemical reaction to occur. Furthermore, when the sensor unit 100 is attached to the measuring device 200, the specific component contained in the sample liquid S can be measured by performing a predetermined voltage sweep scan or the like on the sensor electrode 40 using the measuring device 200. As described above, the sensor unit 100 of this embodiment can achieve measurement with high sensor sensitivity by suppressing contact between the sample liquid S and the sensor electrode 40 from the time the sample liquid S is collected until it is used for measurement, while triggering contact between the sample liquid S and the sensor electrode 40 when the sample liquid S is attached to the measuring device 200. Furthermore, since the variation in measurement accuracy can be reduced, the reproducibility of the measurement results can be maintained at a high level.

[0040] (b) With the measurement system 1 of this embodiment, for example, the measuring device 200 can be installed inside the wall 400a of the toilet 400, and the subject can use the sensor unit 100 to perform measurements. In other words, measurements can be performed easily and with high convenience. Furthermore, by having multiple subjects each wear a sensor unit 100 for one measuring device 200, the measuring device 200 can be shared. This reduces system costs.

[0041] (c) In the sensor unit 100, the flow path 50 preferably has a shape that allows capillary action to occur. This allows the test liquid S stored in the first cell 20 to flow into the second cell 30 more reliably.

[0042] (d) In the sensor unit 100, it is preferable that the volume of the second cell 30 is smaller than the volume of the first cell 20. This allows the test liquid S to be more reliably contacted with the sensor electrode 40 in the second cell 30 even when the amount of test liquid S supplied from the second cell 30 to the first cell 20 is small.

[0043] (e) In the measurement system 1, the measuring device 200 is preferably configured to start electrochemical measurement using the attachment of the sensor unit 100 to the measuring device 200 as a trigger. This allows the test liquid S to be supplied to the second cell 30 and at the same time the test liquid S is brought into contact with the sensor electrode 40 to perform electrochemical measurement. As a result, fluctuations in sensor sensitivity can be avoided, and the reproducibility of measurement results can be improved.

[0044] (f) In the measurement system 1, the measuring device 200 is preferably configured to start electrochemical measurement a predetermined time after the sensor unit 100 is attached to the measuring device 200. This allows measurement to be performed with the flow of the test liquid S in the second cell 30 in a steady state. As a result, the reproducibility of the measurement results can be further improved.

[0045] <Other embodiments> Although the embodiments of the present invention have been described above, the present invention is not limited to the above-described embodiments and can be modified in various ways without departing from the spirit of the present invention.

[0046] In the above embodiment, a case has been described in which the subject collects the test liquid S in the sensor unit 100 and then immediately attaches it to the measuring device 200, but the present invention is not limited to this. The sensor unit 100 can prevent contact between the test liquid S and the sensor electrode 40 until it is attached to the measuring device 200. Therefore, the test liquid S may be collected, and after a predetermined time has passed, the sensor unit 100 may be attached to the measuring device 200 and measurements may be performed. For example, after sample liquids have been collected from multiple subjects, each sensor unit 100 may be attached to the measuring device 200 and measurements may be performed after a certain time has passed.

[0047] In the above embodiment, a case has been described in which the supply of the test liquid S from the first cell 20 to the second cell 30 via the flow path 50 opens the vent pipe 60 due to structural interference between components when the sensor unit 100 is attached to the measuring device 200, but the present invention is not limited to this. Below, a description will be given of modified trigger structures that are caused by structural interference.

[0048] In the above embodiment, the case where the vent pipe 60 is broken and opened by the needle-shaped member 210 has been described, but the opening of the vent pipe 60 is not limited to this. For example, the vent pipe 60 may be configured to include an openable / closable valve (not shown) at the end on the measuring device 200 side, and the valve may be opened by structural interference when the sensor unit 100 is inserted into the insertion port of the measuring device 200. Opening the valve allows the atmosphere in the second cell 30 to escape to the outside. In this way, when the sensor unit 100 is attached to the measuring device 200, the opening of the valve triggers the flow of the test liquid S into the second cell 30. Note that the valve is not particularly limited as long as it is configured to open or close physically or electrically when the sensor unit 100 is attached to the measuring device 200.

[0049] 4(a), a cutout region 62 may be formed in the sensor unit 100 in a region including one end of the vent tube 60 (the region indicated by the dashed line in the figure). In this case, as shown in FIG. 4(b), when the sensor unit 100 is inserted into the insertion port of the measuring device 200, the cutout region 62 is removed in the sensor unit 100 due to structural interference. This removes the end of the vent tube 60. This opens the vent tube 60, allowing the atmosphere in the second cell 30 to escape to the outside. As a result, the test liquid S can flow from the first cell 20 into the second cell 30 via the flow path 50. When the sensor unit 100 is attached to the measuring device 200, the removal of the cutout region 62 triggers the flow of the test liquid S into the second cell 30.

[0050] Alternatively, for example, the supply of the test liquid S from the first cell 20 to the second cell 30 may be initiated by forming a flow path 50 through structural interference, instead of opening the vent pipe 60. Specifically, as shown in FIG. 5(a), a blocked portion 51 (the area indicated by the dashed line in the figure) is provided in a portion of the flow path 50 connecting the first cell 20 and the second cell 30. The blocked portion 51 can be provided, for example, by forming the flow path 50 from a flexible material and bending or bending a portion of the flow path. The test liquid S taken into the first cell 20 will stagnate due to the blocked portion 51, rather than flowing into the second cell 30. In this case, as shown in FIG. 5(b), when the sensor unit 100 is attached to the measuring device 200, the flow path 50 may be deformed to a straight line through structural interference between the measuring device 200 and the sensor unit 100, thereby opening the flow path 50. As a result, for example, by capillary action, the test liquid S flows from the first cell 20 to the second cell 30 via the flow path 50. In Fig. 5(a), the second cell 30 is provided with a hole (not shown) that allows air in the atmosphere to escape to the outside, and is configured so that when the test liquid flows into the second cell 30, the atmosphere in the second cell 30 escapes to the outside.

[0051] Furthermore, instead of providing the blocked portion 51 in the flow path 50, a stopper (not shown) that physically blocks the flow path 50 may be provided. The flow path 50 may be configured so that the stopper can be opened, opened, or broken by structural interference. The stopper can be made of resin, plastic, or the like. For example, when the sensor unit 100 is inserted into the measuring device 200, heat, vibration, or impact can be applied to the flow path 50, destroying the stopper and opening the flow path 50. The stopper may also be made of, for example, a magnetic material, in which case the stopper can be opened and closed by magnetism as structural interference.

[0052] Furthermore, as shown in FIG. 6(a), the first cell 20 may be configured to be compressible by structural interference. The first cell 20 may be formed of, for example, a flexible material (e.g., resin, plastic, etc.). The first cell 20 may be configured to take in the test liquid S through an inlet, but prevent the test liquid S from flowing out of the inlet when compressed. For example, a check valve may be provided at the inlet of the first cell 20. Meanwhile, the second cell 30 may be provided with a hole (not shown) that allows air in the atmosphere to escape to the outside. The flow path 50 may have a diameter that prevents the test liquid S from being drawn up by capillary action. In this case, the test liquid S is taken in by the first cell 20, but remains there without flowing into the second cell 30. Then, as shown in FIG. 6(b), compression of the first cell 20 pressure-feeds the test liquid S through the flow path 50 to the second cell 30. Here, the supply of the test liquid S to the second cell 30 can be triggered by the compression of the first cell 20 when the sensor unit 100 is attached to the measuring device 200 .

[0053] Alternatively, as shown in FIG. 7( a), the second cell 30 may be configured to expand due to structural interference. The second cell 30 may be formed, for example, from a flexible material (such as resin or plastic). The second cell 30 may be configured to have an airtight interior. In this case, the test liquid S is taken into the first cell 20, but because the second cell 30 is airtight, the test liquid S does not flow into the second cell 30 but remains in the first cell 20. As shown in FIG. 7( b), the second cell 30 expands due to structural interference, and the negative pressure generated within the second cell 30 draws the test liquid S from the first cell 20 into the second cell 30 via the flow path 50. In this case, the expansion of the second cell 30 due to structural interference can be used as a trigger to supply the test liquid S to the second cell 30.

[0054] In the above-described embodiment, structural interference caused by mounting the sensor unit 100 on the measuring device 200 has been described as an example of a trigger for causing the test liquid S to flow from the first cell 20 to the second cell 30. However, the present invention is not limited to this. The trigger is not limited to mounting the sensor unit 100 on the measuring device 200. The supply of the test liquid from the first cell 20 to the second cell 30 may be caused by structural interference with components of the sensor unit 100 through external manipulation, such as by hand or with a jig. For example, the sensor unit 100 may store the test liquid S in the sensor unit 100, and the test liquid S may flow into the second cell 30 by external manipulation, such as breaking the end of the vent pipe 60 or removing the cutout region 62, before mounting the sensor unit 100 on the measuring device 200. Alternatively, the supply of the test liquid to the second cell 30 may be caused by non-contact structural interference, such as by a magnet. For example, the sensor unit 100 may be attached to the measuring device 200 after the test liquid S is allowed to flow into the second cell 30 by opening a valve with a magnet or removing a plug.

[0055] Furthermore, in the above-described embodiment, the sensor unit 100 is described as having a flow path 50, but the present invention is not limited to this. For example, as shown in FIG. 8 , the first cell 20 and the second cell 30 may be configured so that their respective spaces are separated by a partition wall 52. In this case, it is preferable to break the partition wall 52 when the sensor unit 100 is attached to the measuring device 200. The crack in the partition wall 52 serves as a flow path, allowing the test liquid S to be supplied from the first cell 20 to the second cell 30.

[0056] In the above embodiment, the sensor electrode 40 is used to measure an electrochemical reaction that occurs upon contact with the test liquid S, but the present invention is not limited to this. For example, a test sheet that changes color upon reaction with a specific component contained in the test liquid S may be used in combination with the sensor electrode 40. In this case, for example, as shown in FIG. 9, a test sheet 70 may be placed inside the second cell 30 together with the sensor electrode 40.

[0057] The test sheet 70 is configured so that the working surface changes color upon contact with the test liquid S. The test sheet 70 makes it possible to measure components in a manner different from that of the sensor electrode 40. Therefore, by using the sensor electrode 40 and the test sheet 70 together, it becomes possible to measure, for example, components that are difficult to measure with the sensor electrode 40 with the test sheet 70. In other words, it becomes possible to simultaneously measure multiple components contained in the test liquid S. There are no particular limitations on the test sheet 70, as long as it changes color upon contact with specific components, and conventionally known test sheets can be used.

[0058] When the test sheet 70 is used, the same problems as those of the sensor electrode 40 may occur. If the test sheet 70 is left in contact with the test liquid S, certain components (such as proteins) in the test liquid S may deposit on the contact surface, causing a change in the degree of discoloration. Furthermore, the amount of change in the degree of discoloration may vary greatly depending on the contact time and environmental conditions. In this regard, by using the configuration shown in FIG. 9, the supply of the test liquid S to the test sheet 70 can be adjusted to coincide with the supply to the sensor electrode 40. As a result, the reproducibility of the measurement results can be further improved.

[0059] Furthermore, when the test sheet 70 is provided, the meter 200 preferably further includes an imaging means for imaging the active surface of the test sheet 70, and is configured so that the imaging of the test sheet 70 is triggered by the attachment of the sensor unit 100 to the meter 200. This allows the color change of the test sheet 70 to be measured in addition to the measurement of the electrochemical reaction at the sensor electrode 40. Alternatively, the meter 200 is preferably configured to start imaging the test sheet 70 after a predetermined time has elapsed since the sensor unit 100 was attached to the meter 200. This allows the color change of the test sheet 70 to be photographed after the inflow of the test liquid S into the second cell 30 has completed and the second cell 30 has reached a steady state. As a result, the reproducibility of the measurement results can be further improved. The measuring means and imaging means for performing electrochemical measurement may be configured as the same device or as separate devices.

[0060] 9, an odor sensor may be used instead of the test sheet 70, or the sensor electrode 40, the test sheet 70, and the odor sensor may be used together. Since odors also change over time, the same problems as with the sensor electrode 40 may arise, but by incorporating the odor sensor into the second cell 30, the above problems can be solved.

[0061] 9 shows the case where the sensor electrode 40 and the test sheet 70 are used together, but it is also possible to use only the test sheet 70. As mentioned above, even in the case of the test sheet 70, variation in measurement accuracy may occur over time due to contact with the test liquid S. In this regard, by adopting the configuration of the above-mentioned embodiment, variation in measurement accuracy with the test sheet 70 can be reduced, and high reproducibility of measurement results can be maintained. It is preferable to use a measuring device 200 that is equipped with an imaging means for imaging the active surface of the test sheet 70.

[0062] 10, a third cell 80 for temporarily storing the test liquid S may be provided on the flow path 50 between the first cell 20 and the second cell 30. The third cell 80 can function as a flow rate regulator that adjusts the time it takes for the test liquid S to flow from the first cell 20 to the second cell 30, or as a reaction unit that contains a predetermined reagent and reacts with the test liquid S. When functioning as a reaction unit, the third cell 80 may contain, for example, a reagent 81 that reacts with a component contained in the test liquid S. Depending on the component contained in the test liquid S, it may be difficult to measure the electrochemical reaction directly. In this regard, the test liquid S can be supplied from the first cell 20 to the second cell 30 via the third cell 80 containing a reagent or the like. This allows the test liquid S to be subjected to electrochemical measurement after reaction.

[0063] Although the above-described embodiment has been described with reference to a single second cell 30, the present invention is not limited thereto. For example, as shown in FIG. 11 , multiple second cells 30 may be configured to communicate with one first cell 20 via a flow path 50. In this case, a vent pipe 60 may be connected to each second cell 30, and the vent pipe 60 may be configured to open due to structural interference. With this configuration, multiple components contained in the test solution S can be measured in parallel by changing the measurement conditions for the sensor electrodes 40 contained in the multiple second cells 30. Note that FIG. 11 illustrates a case in which three second cells 30 each contain a sensor electrode 40 corresponding to three connection terminals 42, and one second cell 30 contains a test sheet 70. The arrangement of the multiple second cells 30 is not particularly limited. For example, the first cell 20 may be centrally positioned, and multiple second cells 30 may be radially positioned around it. Although FIG. 11 illustrates a case in which the number of second cells 30 is four, the number is not particularly limited. Furthermore, although FIG. 11 shows a case where the inflow of the test liquid S is triggered by the opening of the vent pipe 60, the above-mentioned compression of the first cell 20 or expansion of the second cell 30 may also be used as the trigger.

[0064] Furthermore, when multiple second cells 30 are provided, the lengths of the flow paths 50 connected to each of them may be the same or different. When the lengths of the flow paths 50 are the same, the timing at which the test liquid S flows into each of the second cells 30 can be simultaneous. On the other hand, when the lengths of the flow paths 50 are configured to be different, the time it takes for the test liquid S to flow into each of the second cells 30 can be intentionally staggered.

[0065] Furthermore, when multiple second cells 30 are provided, at least one of the multiple flow paths 50 may be provided with a third cell between the first cell 20 and the second cell 30. This allows the time for the test liquid S to flow into the second cell 30 to be adjusted so that it is relatively long for a system that passes through the third cell and relatively short for a system that does not pass through the third cell. Alternatively, in a system in which the test liquid S passes through the third cell, the test liquid S is reacted with a reagent contained in the third cell before being allowed to flow into the second cell 30, while in a system in which the test liquid S does not pass through the third cell, the test liquid S can be allowed to flow directly into the second cell 30.

[0066] 9 illustrates the case where the sensor electrode 40 and the test sheet 70 are contained in one second cell 30. However, when multiple second cells 30 are provided, the sensor electrode 40 and the test sheet 70 may each be contained in a separate second cell 30. If the sensor electrode 40 and the test sheet 70 are present in the same space, they may interfere with each other's measurements. However, by separating them into separate second cells 30, this interference can be reduced.

[0067] Furthermore, in the above embodiment, the case where the test liquid S is poured into the sensor unit 100 before the sensor unit 100 is attached to the measuring device 200 has been described, but the present invention is not limited to this. The test liquid S may be poured into the first cell 20 while the sensor unit 100 is attached to the measuring device 200. In this case, the test liquid S flows into the second cell 30 via the flow path 50 at the same time as the test liquid S is stored in the first cell 20. In other words, the sensor unit 100 can automatically cause the test liquid S to flow into the second cell 30 while attached to the measuring device 200.

[0068] Furthermore, in the above embodiment, the first cell 20 is provided with an inlet 21, and is configured to take in the test liquid S through the inlet 21 and store the test liquid S in its internal space. However, the present invention is not limited to this. For example, the first cell 20 may be configured such that, instead of the inlet 21, a tube capable of taking in the test liquid S from the outside by, for example, capillary action is connected. Also, for example, the first cell 20 may be formed from a moisture-absorbent material and configured to retain and store the test liquid S that is flowing through it.

[0069] Furthermore, in the above embodiment, the measurement system 1 is described as including the sensor unit 100, the measuring device 200, and the judgment support device 300, but the judgment support device 300 may be provided as needed, and may also be omitted.

[0070] In addition, a preferred embodiment is a measurement system for measuring a subject's urine, the measurement system comprising: a portable sensor unit that is detachable from a measuring device for performing electrochemical measurements and configured to store the subject's urine when it is flushed; a measuring device that is installed on the inner wall of the toilet and can be connected to the sensor unit and configured to perform electrochemical measurements; and a judgment support device that is configured to be able to output the measurement results from the measuring device.

[0071] With this measurement system, the measuring device is installed in the wall of the toilet, while the sensor unit is portable by the subject, allowing the subject to collect urine in the toilet and provide the urine to the measuring device with simple operations. Furthermore, since one measuring device can be used to measure urine samples from multiple subjects, system costs can be reduced. Furthermore, with the determination support device, for example, after registering the subject's individual ID, the measurement results can be associated with the ID, allowing the measurement results of a specific subject to be output even when multiple subjects use the device.

[0072] <Preferred aspects of the present disclosure> Preferred aspects of the present disclosure are described below.

[0073] (Appendix 1) A sensor unit configured to be detachable from a measuring device for performing electrochemical measurements, a first cell for temporarily storing a test liquid supplied from the outside; a second cell containing a sensor electrode; The sensor unit is configured so that supply of the test liquid from the first cell to the second cell is triggered by attachment of the sensor unit to the measuring device.

[0074] (Appendix 2) When the test liquid is supplied to the sensor unit in a state where the sensor unit is detached from the measuring device, the test liquid is configured to remain in the first cell without flowing into the second cell. 2. The sensor unit according to claim 1.

[0075] (Appendix 3) a trigger is configured to be generated by structural interference between components of the measuring device and components of the sensor unit when the sensor unit is attached to the measuring device; 10. The sensor unit according to claim 1 or 2.

[0076] (Appendix 4) a vent pipe provided in the second cell for venting the atmosphere in the second cell to the outside; When the sensor unit is attached to the measuring device, structural interference between the components opens the vent pipe, and the test liquid starts to flow into the second cell. 4. The sensor unit according to claim 3.

[0077] (Appendix 5) When the sensor unit is attached to the measuring device, a flow path that connects the first cell and the second cell is formed by structural interference of the components, and the test liquid starts to flow into the second cell via the flow path. 4. The sensor unit according to claim 3.

[0078] (Appendix 6) The first cell and the second cell are separated by a partition wall, When the sensor unit is attached to the measuring device, the partition wall is broken due to structural interference between the components, and a crack formed in the partition wall becomes the flow path. 6. The sensor unit according to claim 5.

[0079] (Appendix 7) When the sensor unit is attached to the measuring device, structural interference between the components causes compression of the first cell, thereby initiating pressure-feeding of the test liquid into the second cell. 4. The sensor unit according to claim 3.

[0080] (Appendix 8) When the sensor unit is attached to the measuring device, the second cell is expanded by structural interference of the components, and the negative pressure generated in the second cell starts suction of the test liquid into the second cell. 4. The sensor unit according to claim 3.

[0081] (Appendix 9) a flow path that connects the first cell and the second cell; the flow path has a shape that causes capillary action when the test liquid is introduced from the first cell into the second cell; The sensor unit according to any one of Supplementary notes 4 to 8.

[0082] (Appendix 10) When the test liquid is supplied to the sensor unit while it is attached to the measuring device, The test liquid is configured to flow from the first cell into the second cell. 10. The sensor unit according to any one of appendices 1 to 9.

[0083] (Appendix 11) The volume of the second cell is smaller than the volume of the first cell. 11. The sensor unit according to any one of claims 1 to 10.

[0084] (Appendix 12) a flow path that connects the first cell and the second cell; a third cell disposed on the flow path for temporarily storing the test liquid; The test liquid is configured to flow into the second cell via the flow path and the third cell. The sensor unit according to any one of appendices 4 to 7.

[0085] (Appendix 13) The third cell contains a reaction reagent capable of reacting with a specific component in the test liquid. 15. The sensor unit of claim 14.

[0086] (Appendix 14) A plurality of second cells for one first cell; a vent pipe provided in each of the plurality of second cells for venting the atmosphere in each second cell to the outside, When the sensor unit is attached to the measuring device, structural interference between the components opens the vent pipe, and the test liquid begins to flow into the second cells. 4. The sensor unit according to claim 3.

[0087] (Appendix 15) a plurality of flow paths that communicate the first cell with each of the plurality of second cells; The plurality of flow paths are configured to have the same or different lengths. 15. The sensor unit of claim 14.

[0088] (Appendix 16) At least one of the plurality of flow paths is provided with a third cell for temporarily storing the test liquid, The test liquid is configured to flow from the first cell into the second cell via the flow path and the third cell. 16. The sensor unit of claim 15.

[0089] (Appendix 17) A test sheet configured such that its active surface changes color upon contact with the test liquid is placed in the second cell. 17. The sensor unit according to any one of claims 1 to 16.

[0090] (Appendix 18) A measuring device configured to be connectable to the sensor unit according to any one of Supplementary Note 1 to Supplementary Note 17, and including a measuring means for performing electrochemical measurement, The measuring device is configured to start the electrochemical measurement using attachment of the sensor unit to the measuring device as a trigger.

[0091] (Appendix 19) A measuring device configured to be connectable to the sensor unit according to any one of Supplementary Note 1 to Supplementary Note 17, and including a measuring means for performing electrochemical measurement, The measuring device is configured to start the electrochemical measurement after a predetermined time has elapsed after the sensor unit is attached to the measuring device.

[0092] (Appendix 20) A measuring device configured to be connectable to the sensor unit described in Supplementary Note 17, and including an imaging means for imaging the active surface of the test sheet, The measuring instrument is configured to photograph the check sheet using attachment of the sensor unit to the measuring instrument as a trigger.

[0093] (Appendix 21) A measuring device configured to be connectable to the sensor unit described in Supplementary Note 17, and including an imaging means for imaging the active surface of the test sheet, The measuring device is configured to photograph the check sheet after a predetermined time has elapsed since the sensor unit was attached to the measuring device.

[0094] (Appendix 22) the test liquid is urine, The measuring device is installed in a toilet. A measuring device according to any one of Supplementary Notes 18 to 21.

[0095] (Appendix 23) A sensor unit configured to be detachable from a measuring device, a first cell for temporarily storing a test liquid supplied from the outside; a second cell containing a test sheet configured such that the active surface changes color upon contact with the test liquid; The sensor unit is configured so that supply of the test liquid from the first cell to the second cell is triggered by attachment of the sensor unit to the measuring device.

[0096] (Appendix 24) 1. A measurement system for measuring urine of a subject, comprising: a portable sensor unit that is detachable from a measuring device for performing electrochemical measurements and configured to store urine from the subject when the urine is flushed; a measuring device connectable to the sensor unit and configured to perform electrochemical measurements; The measuring device is installed on the inner wall of the toilet. Urine measurement system.

[0097] (Appendix 25) The sensor unit includes: a first cell for temporarily storing urine from the subject; a second cell containing a sensor electrode; supply of the test liquid from the first cell to the second cell is triggered by attachment of the sensor unit to the measuring device; The measuring device is configured to start the electrochemical measurement using attachment of the sensor unit to the measuring device as a trigger. 25. The urine measurement system of claim 24. [Explanation of symbols]

[0098] 1. Measurement System 100 sensor units 200 measuring instruments 300 Judgment support device 400 toilet 10 Base material 20 Cell 1 21 Intake port 30 Cell 2 40 Sensor Electrode 41 Wiring 42 Connection terminal 50 flow paths 51 Blockage 60 Vent pipe 61 Valve 62 Cutout Area 70 Inspection Sheet 80 Cell 3 81 Reagents S Test liquid

Claims

1. A sensor unit configured to be detachable from a measuring device for performing electrochemical measurements, A substrate; a first cell disposed on the substrate and configured to temporarily store a test liquid supplied from an external source; a second cell disposed on the substrate and containing a sensor electrode; The sensor unit is configured so that supply of the test liquid from the first cell to the second cell is triggered by attachment of the sensor unit to the measuring device.

2. When the test liquid is supplied to the sensor unit in a state where the sensor unit is detached from the measuring device, the test liquid is configured to remain in the first cell without flowing into the second cell. The sensor unit according to claim 1 .

3. a trigger is configured to be generated by structural interference between components of the measuring device and components of the sensor unit when the sensor unit is attached to the measuring device; The sensor unit according to claim 1 .

4. a vent pipe provided in the second cell for venting the atmosphere in the second cell to the outside; When the sensor unit is attached to the measuring device, structural interference between the components opens the vent pipe, and the test liquid starts to flow into the second cell. The sensor unit according to claim 3 .

5. the vent pipe is configured to be partially broken and opened due to structural interference with the measuring instrument when the sensor unit is attached to the measuring instrument. The sensor unit according to claim 4 .

6. a cutout area configured to be able to cut out an area including a portion of the vent pipe; the vent pipe is configured such that, when the sensor unit is attached to the measuring device, structural interference with the measuring device causes the notched region to be removed and a portion of the vent pipe to be opened. The sensor unit according to claim 4 .

7. When the sensor unit is attached to the measuring device, a flow path is formed that connects the first cell and the second cell due to structural interference between the components, and the test liquid begins to flow into the second cell via the flow path. The sensor unit according to claim 3 .

8. When the sensor unit is attached to the measuring device, structural interference between the components causes compression of the first cell, thereby starting pressure-feeding of the test liquid into the second cell. The sensor unit according to claim 3 .

9. When the sensor unit is attached to the measuring device, the second cell is expanded by structural interference of the components, and the negative pressure generated in the second cell starts suction of the test liquid into the second cell. The sensor unit according to claim 3 .

10. a flow path that communicates the first cell with the second cell, the flow path has a shape that causes capillary action when the test liquid is introduced from the first cell into the second cell; The sensor unit according to claim 4 .

11. a flow path that connects the first cell and the second cell; a third cell provided on the substrate and configured to temporarily store the test liquid on the flow path; The test liquid is configured to flow from the first cell into the second cell via the third cell. The sensor unit according to claim 3 .

12. a plurality of second cells for one first cell; a vent pipe provided in each of the plurality of second cells for venting the atmosphere in each second cell to the outside, When the sensor unit is attached to the measuring device, structural interference between the components opens the vent pipe, and the test liquid begins to flow into the second cells. The sensor unit according to claim 3 .

13. a plurality of flow paths that communicate the first cell with each of the plurality of second cells; The plurality of flow paths are configured to have the same or different lengths. The sensor unit according to claim 12.

14. When the test liquid is supplied to the sensor unit while it is attached to the measuring device, The test liquid is configured to flow from the first cell into the second cell. The sensor unit according to claim 1 .

15. A test sheet configured such that its working surface changes color upon contact with the test liquid is disposed in the second cell. The sensor unit according to claim 1 .

16. A measuring device configured to be connectable to the sensor unit according to claim 1 and equipped with a measuring means for performing electrochemical measurements, The measuring device is configured to start the electrochemical measurement using attachment of the sensor unit to the measuring device as a trigger.

17. A measuring device configured to be connectable to the sensor unit according to claim 1 and equipped with a measuring means for performing electrochemical measurements, The measuring device is configured to start the electrochemical measurement after a predetermined time has elapsed after the sensor unit is attached to the measuring device.

18. A measuring device configured to be connectable to the sensor unit according to claim 15 and including an imaging means for imaging the active surface of the test sheet, The measuring instrument is configured to photograph the check sheet using attachment of the sensor unit to the measuring instrument as a trigger.

19. A measuring device configured to be connectable to the sensor unit according to claim 15 and including an imaging means for imaging the active surface of the test sheet, The measuring device is configured to photograph the check sheet after a predetermined time has elapsed since the sensor unit was attached to the measuring device.

20. the test liquid is urine, The measuring device is installed in a toilet. The measuring device according to any one of claims 16 to 19.

Images