Liquid medicine administration device

Abstract

To prevent liquid medicine from leaking from a connection port due to repetition of attachment and detachment work of a device body and a cradle.SOLUTION: A connection port 40 includes: a liquid medicine introduction part 421 that introduces liquid medicine sent from a liquid sending tube 14; and a first housing part 423 mounted with a liquid sending port 16 and movably attached to the liquid medicine introduction part 421. By moving the first housing part 423 relatively to the liquid medicine introduction part 421 in a state where the liquid sending port 16 is mounted to the first housing part 423, fluid connection with the liquid sending port 16 is achieved.SELECTED DRAWING: Figure 4

Description

[Technical Field]

[0001] The present invention relates to a drug solution administration device that administers a drug solution to a target such as a living body. [Background technology]

[0002] There are known therapies in which a medicinal liquid is continuously administered into a patient's body. For example, one known treatment for diabetes patients is to continuously administer a small amount of insulin into the body. This treatment uses a portable medicinal liquid administration device that can be carried around by being fixed to the user's body or clothing. Using a portable medicinal liquid administration device, it is possible to administer medicinal liquid to the user throughout the day. An insulin pump, which administers insulin to the user, is known as this type of medicinal liquid administration device.

[0003] As one of the portable drug solution administration devices described above, a syringe pump-type drug solution administration device has been proposed, which has a syringe (reservoir) in which the drug solution is stored and a plunger (pump mechanism) that is driven inside the syringe. In the syringe pump-type drug solution administration device, a cannula is liquid-tightly connected to a liquid delivery tube extending from the syringe, and this cannula is inserted and left under the skin of the user, and the drug solution stored in the syringe is administered into the user's body by driving the plunger.

[0004] Patent Document 1 describes a technology in which a needle member (liquid delivery needle) having a needle tube for delivering liquid is provided at the tip of the liquid delivery tube, and a rubber partition (rubber stopper) is provided at a connection port having a cannula, and the liquid delivery needle is pierced through the rubber stopper to connect the liquid delivery tube and the cannula. [Prior art documents] [Patent documents]

[0005] [Patent Document 1] International Publication No. 2008 / 078318 Summary of the Invention [Problem to be solved by the invention]

[0006] However, the technology described in Patent Document 1 has the following problems. A drug solution administration device such as an insulin pump comprises a device main body and a cradle that are detachable from each other. The cradle is attached and fixed to the user's skin, and the device main body is detachable from the cradle. The reservoir, a drive unit for discharging the drug solution from the reservoir, a liquid delivery tube, and a liquid delivery needle are provided in the device main body, and the above-mentioned connection port is provided in the cradle. When the device main body is attached to the cradle, the liquid delivery needle is configured to pierce the rubber stopper.

[0007] However, while using the drug solution administration device, for some reason, such as when the user takes a bath or when filling the reservoir with drug solution, the device main body needs to be removed from the cradle. The device main body then needs to be reattached to the cradle. Therefore, the device main body and the cradle are repeatedly attached and detached during use of the drug solution administration device, and the liquid delivery needle is punctured and removed from the rubber stopper the same number of times. As a result, for example, the puncture hole in the rubber stopper may widen or the rubber stopper itself may be damaged, potentially causing the drug solution to leak from the connection between the rubber stopper and the liquid delivery needle.

[0008] At least one embodiment of the present invention has been made in consideration of the above-mentioned circumstances, and specifically, its object is to provide a drug solution administration device that can prevent leakage of drug solution from the connection port due to repeated attachment and detachment of the device main body and the cradle. [Means for solving the problem]

[0009] The drug solution administration device of this embodiment has an apparatus main body which is equipped with a connection port for holding a cannula to be inserted into a living body and which is attached to the living body, a reservoir for storing the drug solution, a liquid delivery drive unit for delivering the drug solution from the reservoir, a liquid delivery tube through which the drug solution delivered from the reservoir flows, and a hollow cylindrical liquid delivery port which communicates with the liquid delivery tube, and is a drug solution administration device in which the liquid delivery port and the connection port are detachably fluidly connected, and the connection port has a drug solution introduction section for introducing the drug solution delivered from the liquid delivery tube, and a first housing section to which the liquid delivery port is attached and which is attached movably relative to the drug solution introduction section, and is configured to be fluidly connected to the liquid delivery port by moving the first housing section relative to the drug solution introduction section when the liquid delivery port is attached to the first housing section. [Effects of the Invention]

[0010] According to at least one embodiment of the present invention, leakage of the medicinal liquid from the connection port caused by repeated attachment and detachment of the device main body and the cradle can be prevented. [Brief explanation of the drawings]

[0011] [Figure 1] 1 is a schematic perspective view of a drug solution administration device according to a first embodiment. [Figure 2] 1 is a schematic exploded perspective view of a chemical liquid administration device according to a first embodiment. FIG. [Figure 3] 1 is a schematic partial perspective view of a drug solution administration device according to a first embodiment, as viewed from the side. FIG. [Figure 4] 3 is a schematic cross-sectional view showing a sealed state of a connection port of the drug solution administration device according to the first embodiment. FIG. [Figure 5] 1 is a schematic cross-sectional view showing an open state of a connection port of a drug solution administration device according to a first embodiment; [Figure 6] 5A to 5C are schematic cross-sectional views showing the operation of the drug solution administration device according to the first embodiment during use. [Figure 7] 5A to 5C are schematic cross-sectional views showing the operation of the drug solution administration device according to the first embodiment during use. [Figure 8] 5A to 5C are schematic cross-sectional views showing the operation of the drug solution administration device according to the first embodiment during use. [Figure 9] 5A to 5C are schematic cross-sectional views showing the operation of the drug solution administration device according to the first embodiment during use. [Figure 10] FIG. 6 is a schematic cross-sectional view of a drug solution administration device according to a second embodiment. DETAILED DESCRIPTION OF THE INVENTION

[0012] Hereinafter, embodiments of the present invention will be described in detail with reference to the drawings. The embodiments shown here are merely examples for embodying the technical concept of the present invention and are not intended to limit the present invention. Furthermore, all other embodiments, examples, and operational techniques that can be conceived by those skilled in the art without departing from the spirit of the present invention are included within the scope and spirit of the present invention, as well as within the scope of the claims and their equivalents.

[0013] Furthermore, for the convenience of illustration and ease of understanding, the drawings attached to this specification may be represented schematically with the scale, aspect ratio, shape, etc. appropriately changed from the actual product, but these are merely examples and do not limit the interpretation of the present invention.

[0014] Furthermore, in the following description, when ordinal numbers such as "first" and "second" are used, unless otherwise specified, they are used for convenience and do not stipulate any particular order.

[0015] For ease of explanation, the present specification uses XYZ coordinates as shown in the drawings. That is, the "Z direction" is the direction along the vertical direction, the "X direction" is a direction perpendicular to the Z direction and parallel to the horizontal plane, and the "Y direction" is another direction perpendicular to the Z direction and parallel to the horizontal plane (direction perpendicular to the X direction). Therefore, in the drug solution administration devices 100 and 110 according to this embodiment, the Z direction coincides with the thickness direction (up-down direction) of the device, the X direction coincides with the longitudinal direction (front-rear direction) along the axial direction of the device, and the Y direction coincides with the lateral direction (width direction) of the device that is perpendicular to the longitudinal direction.

[0016] The medicinal liquid administration devices 100, 110 according to the present embodiment are devices for continuously administering medicinal liquid into the body of a user. Examples of medicinal liquids administered using the medicinal liquid administration devices 100, 110 include insulin, analgesics, anticancer drugs, HIV (Human Immunodeficiency Virus) drugs, iron chelating drugs, and drugs for treating pulmonary hypertension. In the present embodiment, a portable insulin pump that administers insulin into the body of a user is assumed as an example of the medicinal liquid administration device 100, 110. The medicinal liquid administration devices 100, 110, which are insulin pumps, are used by being attached to the surface of a living body. The surface of a living body is typically the surface of the user's skin. The medicinal liquid administration devices 100, 110 are attached, for example, to the user's abdomen.

[0017] [First embodiment] FIG. 1 is a schematic perspective view showing the appearance of a medicinal liquid administration device 100 according to a first embodiment, and FIG. 2 is a schematic exploded perspective view showing the main parts of the overall configuration of the medicinal liquid administration device 100. As shown in FIG.

[0018] <Configuration> As shown in Figure 1 or 2, the drug solution administration device 100 generally comprises a first main body portion 10 that holds a reservoir 12 in which the drug solution is stored, a second main body portion 20 that holds a liquid delivery drive unit 23 for delivering the drug solution in the reservoir 12 into the living body, and a cradle 30 that holds a cannula 50 and is attached to the surface of the living body.

[0019] The first main body 10 is a disposable part. The second main body 20 is a reusable part. The first main body 10 and the second main body 20 are separable from each other and can be connected to each other. The drug solution administration device 100 is configured by connecting the cradle 30 to the device main body 101 in which the first main body 10 and the second main body 20 are connected.

[0020] <First main body part> The first main body 10 has a housing 11, a reservoir 12, an extrusion unit 13, a liquid supply tube 14, and a power supply unit 15. The housing 11 is formed in a substantially rectangular shape in a plan view (viewed in the Z direction). The housing 11 is also a substantially rectangular parallelepiped that is open at the top.

[0021] As shown in FIG. 2, the housing 11 includes a flat bottom surface 11a and a side wall 11b that rises along the entire outer periphery of the bottom surface 11a. The bottom surface 11a is a plate that divides the housing 11 in the Z direction. When the first main body 10 is attached to the cradle 30, the bottom surface 11a is disposed opposite the cradle 30. A reservoir 12, an extrusion unit 13, a liquid delivery tube 14, and a power supply unit 15 are attached to the surface of the bottom surface 11a facing the second main body 20 (the upper surface of the bottom surface 11a). The bottom surface 11a also functions as the bottom surface 101a of the device main body 101 in which the second main body 20 is attached to the first main body 10.

[0022] The outer peripheral surface of the side wall portion 11b is provided with a first guide portion 11e that engages with a second guide portion 31d, which will be described later, when the device main body 101 is attached to the cradle 30. The first guide portion 11e and the second guide portion 31d have complementary shapes, and when engaged, function as guide portions that guide the alignment of the device main body 101 when attached to the cradle 30. In the first embodiment, the first guide portion 11e is a convex portion that protrudes outward from the outer peripheral surface of the side wall portion 11b.

[0023] The housing 11 includes a first storage section 11c surrounded by a bottom surface section 11a and a side wall section 11b. The first storage section 11c is provided on the upper surface side of the bottom surface section 11a and stores a reservoir 12, a power supply section 15, etc. When the cover 21 of the second main body section 20 and the housing 11 are connected, the liquid delivery drive section 23 attached to the inside of the cover 21 is stored within the first storage section 11c.

[0024] The housing 11 includes a second storage section 11d. The second storage section 11d is recessed in the thickness direction (Z direction) of the housing 11 toward the lower surface of the bottom surface section 11a (the surface connected to the cradle 30). The second storage section 11d stores the connection port 40 of the cradle 30 and the like. The first storage section 11c and the second storage section 11d are separated by a partition wall 11f.

[0025] Reservoir 12 includes an outer cylinder 12a that stores a medicinal liquid to be administered to a user, and expels the medicinal liquid from outer cylinder 12a by pressing action of extrusion unit 13. Reservoir 12 has a medicinal liquid discharge port (not shown) at its tip, and one end of liquid feed tube 14 is connected to this discharge port. The other end of liquid feed tube 14 is connected to liquid feed port 16 from the first storage unit 11c side of housing 11. Reservoir 12 has gear 12b near its end. Gear 12b rotates by receiving driving force from liquid feed drive unit 23. An end of the rotation shaft of gear 12b is engaged with feed screw 12c. Feed screw 12c is provided so as to be movable in the X direction. In reservoir 12, gear 23b and gear 12b rotate when driven by liquid feed drive unit 23, and as feed screw 12c rotates in accordance with the rotation of gear 12b, reservoir 12 moves extrusion unit 13 in the X direction. The liquid medicine in the reservoir 12 is delivered to the liquid delivery tube 14 according to the amount of pressure applied by the extrusion part 13, which moves with the rotation of the feed screw 12c. The liquid delivery tube 14 is detachably fluidly connected (a connected state in which the liquid medicine can flow) to a connection port 40, which will be described later, via the liquid delivery port 16.

[0026] The reservoir 12 is not limited to a syringe, but may be any other container capable of storing a liquid medicine, such as a soft bag, etc. The reservoir 12 may be any container capable of discharging the liquid medicine by the extrusion portion 13.

[0027] The power supply unit 15 supplies the driving power required to drive the medicinal solution administration device 100. The power supply unit 15 is composed of a battery that serves as a power source for driving, for example, the liquid delivery drive unit 23, and a battery box that houses the battery. The power supply unit 15 is connected to electrodes (not shown) on the circuit board 22. The power supply unit 15 may be disposed inside the lid 21 as a component of the second main body unit 20.

[0028] As shown in Fig. 3, the liquid supply port 16 is provided so as to protrude into the second storage section 11d. The liquid supply port 16 is a hollow cylinder with a liquid supply hole 16a formed at its tip. The base end of the liquid supply port 16 is connected to the liquid supply tube 14, and the tip is attached to a connection port 40 provided on the cradle 30. The liquid supply hole 16a is formed so as to penetrate the liquid supply port 16 along the central axis of the liquid supply port 16. The open end surface of the liquid supply hole 16a may have, for example, radial (in other words, cross-shaped) grooves centered on the liquid supply hole 16a.

[0029] <Second main body> The second main body 20 has a cover 21, a circuit board 22, and a liquid delivery drive unit 23, and is attached to the first main body 10. The second main body 20 is a portion where the electronic control functions of the medicinal liquid administration device 100 are collectively arranged. The second main body 20 is configured by accommodating electronic control function components such as the circuit board 22 and the liquid delivery drive unit 23 inside the cover 21.

[0030] The lid 21 is configured to be detachable from the housing 11 of the first main body 10. The upper surface of the lid 21 forms the top surface of the medicinal solution administration device 100. Electronic control function components such as a circuit board 22 and a liquid delivery drive unit 23 are attached to the lower surface side of the lid 21.

[0031] The liquid delivery drive unit 23 includes a motor 23a and a gear 23b. The motor 23a is a drive source for moving the extrusion unit 13 in a predetermined direction to deliver the liquid medicine from the reservoir 12. The gear 23b is made up of multiple gear stages, and the final gear stage meshes with the gear 12b. This allows the driving force (rotational force) of the motor 23a to be transmitted to the gear 12b via the gear 23b.

[0032] The second main body 20 also includes a liquid delivery amount detection unit 24 that can detect the amount of liquid medicine delivered based on the rotation speed of a motor 23a, such as an encoder, a communication unit 25 that is an interface for enabling communication with the outside, and a control unit 26 that is configured by a known microcomputer including a CPU, ROM, RAM, etc. The communication unit 25 and the liquid delivery drive unit 23 operate based on a predetermined program under the control of the control unit 26.

[0033] Cradle The cradle 30 has a holder case 31 and a connection port 40. The holder case 31 has a mounting surface 31a and a side wall 31b. The connection port 40 is attached to the upper surface (mounting surface 31a) of the holder case 31. The device main body 101 is temporarily attached to the cradle 30 from diagonally above (see FIG. 7) and then moved downward with the connection port 40 at the center to be completely attached to the cradle 30.

[0034] An adhesive portion 31c is provided on the bottom surface of the holder case 31. A portion of the adhesive portion 31c protrudes outward from the mounting surface portion 31a and is used to attach the cradle 30 to the surface of the living body (the user's skin). The mounting surface portion 31a is formed in a substantially rectangular shape in a plan view.

[0035] When the first main body 10 is attached to the cradle 30, the bottom surface 101a of the device main body 101 (bottom surface 11a of the first main body 10) is placed on the placing surface 31a. The side wall 31b is formed standing upright from three sides of the placing surface 31a in the thickness direction (Z direction) of the cradle 30, and no side wall 31b is formed on the remaining side of the placing surface 31a. The side wall 31b may be provided so as to surround the placing surface 31a on all four sides along the outer periphery.

[0036] The cradle 30 includes a second guide portion 31d for guiding the alignment of the device main body 101 when it is attached. The second guide portion 31d has a shape complementary to that of the first guide portion 11e and engages with it. In the first embodiment, the second guide portion 31d is a recessed groove provided on the inner surface of the side wall portion 31b near the connection port 40, extending from the base end side to the side wall portion 31b in a substantially vertical direction (X direction) and bending obliquely upward from the middle along the removal direction D2 of the device main body 101. In other words, the second guide portion 31d has a shape that follows the attachment path when the device main body 101 is attached to the cradle 30. When the device main body 101 is attached, the second guide portion 31d engages with the first guide portion 11e provided on the outer peripheral surface of the side wall portion 11b of the first main body portion 10 and guides the movement direction of the first guide portion 11e.

[0037] <Connection port> 4 or 5, the connection port 40 is provided on the upper surface of the mounting surface 31a of the cradle 30. The connection port 40 includes a port main body 41, a first connection part 42, and a second connection part 43. The connection port 40 is a port that is connected to the liquid feed tube 14 via the first connection part 42.

[0038] The first connecting part 42 is disposed on the side wall of the port main body 41 opposite the liquid supply port 16, and functions as an introduction port for introducing the medicinal liquid delivered through the liquid supply port 16 into the connection port 40 when the first main body part 10 is attached to the cradle 30. The second connecting part 43 is disposed above the connection port 40, and is punctured with a known puncture tool (not shown) when the cannula 50 is placed in the living body. The second connecting part 43 functions as a puncture port from which only the puncture needle is removed after the cannula 50 is placed.

[0039] A holding portion 44 is provided at the bottom of the port body 41 of the connection port 40 to hold the proximal side of a cannula 50 that is placed in the living body and delivers a medicinal liquid into the living body. The cannula 50 protrudes from the holding portion 44 toward the user's body, and at least the tip portion is placed in the living body. The cannula 50 is made of a resin material such as polyurethane, nylon, or ethylene-tetrafluoroethylene copolymer (ETFE). After the cannula 50 is inserted into the living body, the puncture tool is removed from the cradle 30 and discarded.

[0040] Holding portion 44 is formed in a funnel shape to guide the medicinal liquid that has flowed in from a communication passage 421a of medicinal liquid introduction portion 421, which will be described later, to cannula 50. A predetermined internal space 45 is provided above holding portion 44, and is in communication with first connection portion 42. The medicinal liquid introduced from first connection portion 42 is introduced into internal space 45, and then flows down holding portion 44 to cannula 50.

[0041] First connecting portion 42 includes a drug solution introducing portion 421, a first sealing portion 422, a first housing portion 423, a support portion 424, and a second housing portion 425. First connecting portion 42 communicates with internal space 45 of port main body 41.

[0042] Liquid medicine introduction part 421 has a communication passage 421a extending outward from internal space 45. Liquid medicine introduction part 421 is a flow path for guiding the liquid medicine delivered from liquid delivery port 16 through first housing part 423 to holding part 44. The base end of communication passage 421a of liquid medicine introduction part 421 communicates with internal space 45, and a hollow cylindrical stopper 421b is disposed at the tip (the end opposite internal space 45).

[0043] Cylindrical stopper 421b is a hollow member having opening 421c at its tip. Cylindrical stopper 421b is attached to the tip of communicating passage 421a with a portion of its tip exposed to the outside. When first housing portion 423 is in the closed position, opening 421c of cylindrical stopper 421b comes into close contact with sealing portion 423d provided on the base end surface of first housing portion 423. This blocks communication between chemical solution introduction portion 421 and the outside. Cylindrical stopper 421b can be made of a flexible and sealing material, similar to first seal portion 422. This allows cylindrical stopper 421b to come into close contact with the end surface of first housing portion 423, where second communication hole 423c is provided, when first housing portion 423 is in the open position, thereby achieving a liquid-tight connection between chemical solution introduction portion 421 and first housing portion 423. Furthermore, when first housing portion 423 is in the closed position, cylindrical plug 421b can be tightly fitted to sealing portion 423d, thereby reliably closing chemical solution introduction portion 421 and sealing internal space 45.

[0044] The aforementioned "closed position" is a position to which the first housing part 423 is moved to close the communication passage 421a and cut off the fluid connection between the liquid supply port 16 and the connection port 40 when the device main body 101 is not attached to the cradle 30. The "open position" is a position to which the first housing part 423 is moved to open the communication passage 421a and fluidly connect the liquid supply port 16 and the connection port 40 when the device main body 101 is attached to the cradle 30.

[0045] The first housing part 423 is a hollow cylindrical member having an inner cavity 423a, and is rotatably supported by a support part 424 relative to the port body 41. The shape of the base end side of the first housing part 423 is formed to fit the outline of the surface of the port body 41 facing the liquid feed port 16. As a result, during a rotation operation, the first housing part 423 can pivot in the Z direction with the support part 424 as a fulcrum without getting caught on the port body 41.

[0046] A first communication hole 423b communicating with the outside is provided on the distal end surface of first housing part 423, and a second communication hole 423c that can communicate with communication passage 421a of medicinal liquid introduction part 421 is provided on the proximal end side. Lumen 423a of first housing part 423 communicates with liquid delivery hole 16a of liquid delivery port 16 attached to first communication hole 423b. As a result, when first housing part 423 is in the open position, the medicinal liquid delivered from liquid delivery port 16 flows into medicinal liquid introduction part 421 through second communication hole 423c.

[0047] First housing portion 423 includes sealing portion 423d on the base end side. Sealing portion 423d blocks communication between chemical solution introduction portion 421 and the outside. Specifically, sealing portion 423d is provided around the opening of chemical solution introduction portion 421. When first housing portion 423 is in the closed position, sealing portion 423d comes into close contact with cylindrical stopper 421b that covers the inner circumferential surface of the opening of chemical solution introduction portion 421, thereby blocking communication between chemical solution introduction portion 421 and the outside. In the first embodiment, sealing portion 423d is provided on the inner surface side of connecting portion 424b, which will be described later, on the base end side of first housing portion 423.

[0048] When the first housing portion 423 is in the closed position as shown in FIG. 4, the sealing portion 423d and the cylindrical stopper 421b come into close contact with each other. More specifically, when the support portion 424 is rotated and the tip (first communication hole 423b) of the first housing portion 423 linked to the support portion 424 faces obliquely upward as shown in FIG. 4, the sealing portion 423d and the cylindrical stopper 421b come into close contact with each other. When the first housing portion 423 is in the closed position, the sealing portion 423d covers the end face (opening hole 421c) of the cylindrical stopper 421b and comes into close contact with each other. This seals the internal space 45 when the device main body 101 is not attached to the cradle 30.

[0049] Furthermore, when the first housing part 423 is in the closed position, the first communication hole 423b faces the removal direction D2 of the device main body 101. This makes it easy for the user to insert the liquid supply port 16 into the first communication hole 423b, and therefore makes it easy to attach the device main body 101 to the cradle 30.

[0050] As shown in FIG. 5, when the first housing portion 423 is in the open position, the second communication hole 423c communicates with the opening hole 421c of the cylindrical stopper 421b. Specifically, when the support portion 424 is rotated and the tip (first communication hole 423b) of the first housing portion 423 linked to the support portion 424 faces the X direction, the second communication hole 423c communicates with the opening hole 421c of the cylindrical stopper 421b. When the first housing portion 423 is in the open position, the sealing portion 423d covers at least a portion of the end face of the cylindrical stopper 421b and exposes the opening hole 421c to the inner cavity 423a. This allows the opening hole 421c to communicate with the second communication hole 423c. In the open position, the device main body 101 and the cradle 30 are fully attached to each other. The internal space 45 is in communication with the liquid supply port 16 when the device main body 101 is completely attached to the cradle 30, thereby establishing a liquid medicine flow path. In other words, the liquid supply port 16 (liquid supply tube 14) and the connection port 40 are fluidly connected.

[0051] An engagement groove 423e that engages with an engagement claw 425b of the second housing part 425 (described later) is provided on the outer periphery of the first housing part 423. The engagement groove 423e is at least one annular groove that runs around the outer periphery of the first housing part 423.

[0052] The first seal portion 422 is disposed near the first communication hole 423b in the inner cavity 423a of the first housing portion 423. The first seal portion 422 comes into close contact with the outer periphery of the tip of the liquid feed port 16 attached to the first communication hole 423b. Therefore, the first seal portion 422 can improve the liquid-tightness when the liquid feed port 16 and the first housing portion 423 are connected. The first seal portion 422 can be an O-ring made of a flexible and sealing material such as a rubber material or a thermoplastic elastomer.

[0053] The support portion 424 is supported rotatably in the circumferential direction of a support shaft 41a provided on the port main body 41 and is connected to the first housing portion 423. In the first embodiment, the support portion 424 is provided integrally with the first housing portion 423. The support portion 424 has a generally U-shaped plan view (shape viewed from the Z direction) so as to cover at least a portion of the periphery of the port main body 41 in three directions. The support portion 424 includes a pair of base portions 424a arranged opposite each other with the port main body 41 therebetween, and a connecting portion 424b provided continuous with the distal ends of the pair of base portions 424a so as to be integral with the base portions 424a. The first housing portion 423 is provided with a generally central portion of the connecting portion 424b. The second communication hole 423c of the first housing portion 423 is provided to penetrate the connecting portion 424b. In connection part 424b, a part that is located below second communication hole 423c and that is formed in a shape that follows the periphery of the opening of chemical solution introduction part 421 functions as sealing part 423d.

[0054] The shape of the support portion 424 is not particularly limited as long as it has the function of supporting the first housing portion 423 so that it can move between the closed position and the open position relative to the port main body 41. In addition, although the first housing portion 423 and the support portion 424 are described as having separate configurations in the first embodiment, they may also be one member that configures the first housing portion 423.

[0055] The second housing part 425 is attached to cover the tip portion of the first housing part 423. An attachment hole 425a, into which the liquid feed port 16 is inserted and which communicates with the first communication hole 423b, is provided in the approximate center of the second housing part 425. When the second housing part 425 and the first housing part 423 are in the open position, the attachment hole 425a and the opening position of the first communication hole 423b coincide with each other in the axial direction of the first housing part 423. As a result, when the second housing part 425 is attached to the first housing part 423, the attachment hole 425a communicates with the first communication hole 423b. The first seal part 422 is held between the second housing part 425 and the first housing part 423, and a liquid-tight seal is formed between this first seal part 422 and the outer periphery of the liquid feed port 16.

[0056] A plurality of engagement claws 425b are provided on the outer periphery of second housing part 425, protruding toward the base end. When second housing part 425 is attached to first housing part 423, hook-shaped portions on the tip side of engagement claws 425b engage with engagement grooves 423e of first housing part 423. Note that the number and formation positions of engagement claws 425b are not particularly limited, but in consideration of mounting stability during attachment, it is preferable to provide engagement claws at equal angular intervals in the circumferential direction of second housing part 425.

[0057] The second connecting part 43 includes an opening 431 and a stopper 432, and after the cannula 50 is inserted into the living body together with the puncture needle, only the puncture needle is inserted and removed. The opening 431 is provided on the upper surface of the port main body 41. The stopper 432 is disposed directly below the opening 431.

[0058] Stopper 432 is disposed above holding portion 44 at a position facing the proximal end of cannula 50. Stopper 432 can be made of a flexible, sealing material, such as various rubber materials such as silicone rubber or natural rubber, or various thermoplastic elastomers such as polyurethane-based, polyester-based, polyamide-based, olefin-based, or styrene-based. After the puncture needle that has penetrated stopper 432 is removed, stopper 432 seals second connecting portion 43 to isolate internal space 45 from the external environment.

[0059] <Operation> Next, the operations performed when attaching the first main body part 10 to the cradle 30 and when detaching the first main body part 10 from the cradle 30 in the drug solution administration device 100 of the first embodiment will be explained with reference to Figures 6 to 9.

[0060] As a preliminary step before using the drug solution administration device 100, the user attaches the cradle 30 to the surface of the living body and places the cannula 50 inside the living body. When placing the cannula 50, the user attaches the adhesive portion 31c of the cradle 30 to the skin, and inserts the cannula 50 into the living body by puncturing the second connecting portion 43 with a puncture needle. In this way, the cradle 30 is attached to the surface of the living body with the cannula 50 placed inside the living body.

[0061] Next, the user attaches the second main body 20 to the first main body 10 to assemble the device main body 101. As shown in FIG. 6, the first housing portion 423 of the connection port 40 faces diagonally upward (toward the upper right in the figure), which is the removal direction D2 of the device main body 101, before the device main body 101 is attached to the cradle 30. That is, before the device main body 101 is attached to the cradle 30, the first housing portion 423 of the connection port 40 is located in the closed position. As a result, the cylindrical plug 421b is tightly fitted to the sealing portion 423d of the first housing portion 423, thereby blocking the communication passage 421a and blocking communication with the outside. Therefore, the internal space 45 of the connection port 40 is sealed.

[0062] As shown in FIG. 7, the user brings the assembled device main body 101 close to the cradle 30 from diagonally upward (upper right in the figure) in the mounting direction D1 (lower right in the figure), engages the first guide portion 11e with the second guide portion 31d, and inserts the liquid supply port 16 into the mounting hole 425a of the second housing portion 425 to mount it to the first housing portion 423. This temporarily mounts the device main body 101 to the cradle 30. As shown in FIG. 7, when the device main body 101 and the cradle 30 are temporarily mounted, the liquid supply port 16 is mounted to the first housing portion 423 and communicates with it. However, because the first housing portion 423 is in the closed position as shown in FIG. 7, the cylindrical stopper 421b and the sealing portion 423d are in close contact with each other, resulting in a closed state for the communication passage 421a. Therefore, the internal space 45 of the connection port 40 remains sealed even in the state shown in FIG. 7.

[0063] 8, from the state in which the device main body 101 and the cradle 30 are temporarily attached, the user moves the bottom surface 101a (bottom surface 11a) of the device main body 101 toward the mounting surface 31a of the cradle 30, and attaches the device main body 101 onto the cradle 30. In detail, the user moves the device main body 101, which has been temporarily attached to the cradle 30 from diagonally above, downward with the support portion 424 as the center of rotation, and places the bottom surface 101a of the device main body 101 on the mounting surface 31a. In addition, the support portion 424 rotates in conjunction with the movement of the device main body 101, and moves the orientation of the first housing portion 423 so that it faces in the X direction from diagonally above. As a result, the first housing portion 423 moves from the closed position to the open position. As a result, the connection port 40 is opened, a liquid medicine flow path is formed that connects the internal space 45 and the liquid delivery port 16, and the liquid medicine administration device 100 can administer the liquid medicine.

[0064] The medicinal liquid flow path is a flow path that connects to cannula 50 within connection port 40. Therefore, liquid feed tube 14 that connects to reservoir 12 and cannula 50 that is punctured into a living body are fluidly connected. Therefore, when a user starts medicinal liquid administration device 100, liquid feed drive unit 23 is driven at a predetermined timing to cause the medicinal liquid stored in reservoir 12 to flow from liquid feed port 16 into the inside of first housing portion 423 via liquid feed tube 14. The medicinal liquid that has flowed into the inside of first housing portion 423 then passes through medicinal liquid introduction portion 421 and flows from internal space 45 of port main body 41 into cannula 50, and is introduced into the living body.

[0065] When the first main body unit 10 is to be detached from the cradle 30 while the medicinal solution administration device 100 is in use, the user lifts the device main body 101 upward around the support portion 424 as the rotation center, in the direction opposite to the state in which the device main body 101 is completely attached to the cradle 30, as shown in FIG. 9 , and then moves the device main body 101 away from the cradle 30 in a detachment direction D2 (upper right direction in the figure), which is the opposite direction to the attachment direction D1. This detaches the device main body 101 from the cradle 30, and the liquid delivery port 16 disengages from the second housing portion 425 of the first connection portion 42, thereby releasing the connection. Furthermore, as the device main body 101 is detached, the first housing portion 423 moves from the open position to the closed position. When the first housing portion 423 moves to the closed position, the cylindrical stopper 421b comes into close contact with the sealing portion 423d. This seals the connection port 40, sealing the internal space 45 and blocking communication with the outside.

[0066] [Second embodiment] Next, a drug solution administration device 110 according to a second embodiment will be described with reference to Fig. 10. In the second embodiment, components having the same functions as those in the first embodiment described above are denoted by the same reference numerals, and detailed description thereof will be omitted. Configurations, members, and usage methods that are not specifically mentioned may be similar to those in the above-described embodiment.

[0067] <Configuration> In the drug solution administration device 110 according to the second embodiment, the support portion 424 is configured to be biased by a biasing member 424c so that the first housing portion 423 is positioned at the closed position.

[0068] 10, the support portion 424 includes a biasing member 424c. The biasing member 424c is disposed on the support shaft 41a and is configured as a member (e.g., a torsion coil spring) capable of applying a biasing force to the support portion 424 in a predetermined direction. When the device main body 111 and the cradle 30 are not yet attached to each other, the support portion 424 is biased by the biasing force of the biasing member 424c so that the first communication hole 423b of the first housing portion 423 faces the removal direction D2. This allows the first housing portion 423 to be always positioned in the closed position when the device main body 111 and the cradle 30 are not yet attached to each other. Therefore, the sealing portion 423d and the cylindrical stopper 421b are in close contact with each other, maintaining the closed state of the drug solution introduction portion 421. Furthermore, when the device main body 111 is completely attached to the cradle 30, the support portion 424 rotates against the biasing force of the biasing member 424c, and moves the first housing portion 423 to the open position.

[0069] In the medicinal solution administration device 110 according to the second embodiment, the attachment direction D1 when the first main body unit 10 is attached to the cradle 30 is a direction that faces diagonally downward from above the cradle 30. Therefore, in the medicinal solution administration device 110 according to the second embodiment, the operations when temporarily attaching and attaching the device main body 111 to the cradle 30 are the same as those in the first embodiment (see FIGS. 6 to 8).

[0070] In the chemical solution administration device 110 of the second embodiment, a removal direction D2 in which the device body 111 is removed from the cradle 30 is a direction along the X direction (rightward in FIG. 10 ). In the chemical solution administration device 110 of the second embodiment, the support portion 424 is biased by the biasing member 424c so that the first housing portion 423 is positioned in the closed position. Therefore, even if the removal direction D2 of the device body 111 is a direction along the X direction, the support portion 424 can move the first housing portion 423 from the open position to the closed position by the biasing force of the biasing member 424c after the device body 111 is removed. Therefore, in the chemical solution administration device 110 of the second embodiment, when the device body 111 is to be removed from the cradle 30, it is only necessary to slide the attached device body 111 along the X direction, which simplifies the attachment and detachment operation. Furthermore, since the support portion 424 is biased by the biasing member 424c so that the first housing portion 423 is positioned in the closed position, even when the device main body 111 is not attached to the cradle 30, communication between the connection port 40 and the outside is always blocked, and the internal space 45 can be kept sealed.

[0071] In the second embodiment, the removal direction D2 of the device main body 111 is set to the direction along the X direction, but similar to the first embodiment, it may be set to the direction opposite to the mounting direction D1.

[0072] The operation of the medicinal liquid administration device 110 of the second embodiment having the above-described configuration until the device main body 111 is completely attached to the cradle 30 is the same as the operation of the medicinal liquid administration device 100 of the first embodiment described above (see Figures 6 to 8).

[0073] When removing the first main body portion 10 from the cradle 30 while using the medical solution administration device 110, the user slides the device main body 111 away from the cradle 30 in a removal direction D2 along the X direction. This causes the device main body 111 to be removed from the cradle 30, and the liquid delivery port 16 is disengaged from the first housing portion 423 of the first connection portion 42, thereby releasing the connection. Furthermore, when the device main body 111 is removed, the first housing portion 423 moves from the open position to the closed position in response to the rotational movement of the support portion 424 biased by the biasing member 424c. When the first housing portion 423 moves to the closed position, the cylindrical stopper 421b comes into close contact with the sealing portion 423d. This seals the connection port 40, sealing the internal space 45 and blocking communication with the outside.

[0074] [Action and effect] As described above, the drug solution administration devices 100, 110 of this embodiment have a device main body 101, 111 which includes a cradle 30 attached to the living body and to which a connection port 40 for holding a cannula 50 to be inserted into the living body is attached, a reservoir 12 for storing the drug solution, a liquid delivery drive unit 23 for delivering the drug solution from the reservoir 12, a liquid delivery tube 14 through which the drug solution delivered from the reservoir 12 flows, and a hollow cylindrical liquid delivery port 16 communicating with the liquid delivery tube 14, and are devices in which the liquid delivery port 16 and the connection port 40 are detachably fluidly connected. The connection port 40 comprises a drug solution introduction section 421 for introducing the drug solution delivered from the liquid delivery tube 14, and a first housing section 423 to which the liquid delivery port 16 is attached and which is movably attached relative to the drug solution introduction section 421. With the liquid delivery port 16 attached to the first housing section 423, the first housing section 423 is moved relative to the drug solution introduction section 421 to achieve fluid connection with the liquid delivery port 16.

[0075] In conventional technology, a liquid delivery needle with a sharp tip is repeatedly inserted into and removed from a rubber stopper (septum) provided in a connection port to perform fluid connection. As a result, with the conventional technology, as the number of times the device body and the cradle are attached and detached increases, for example, the puncture hole in the rubber stopper widens or the rubber stopper itself becomes damaged, which can lead to leakage of the medicinal solution from the connection point between the rubber stopper and the liquid delivery needle. Furthermore, if the liquid delivery needle is not inserted into the rubber stopper in the correct direction due to an operational error or other reason, the rubber stopper is further damaged. In contrast, the medicinal solution administration devices 100 and 110 according to the present embodiment are configured to deliver medicinal solution to the connection port 40 via the liquid delivery port 16 of the device body 101 and 111, and are configured to fluidly connect the liquid delivery port 16 and the connection port 40 by attaching the liquid delivery port 16 to a first housing portion 423. As a result, the medicinal liquid administration devices 100, 110 according to the present embodiment prevent leakage of medicinal liquid from the connection port due to damage and deterioration of the rubber stopper, which has been a problem in the prior art. Furthermore, the medicinal liquid administration devices 100, 110 can fluidly connect with the liquid delivery port 16 by moving the first housing part 423 relative to the medicinal liquid introduction part 421 in a state in which the liquid delivery port 16 is attached to the first housing part 423 (more specifically, a state in which the liquid delivery port 16 of the device main body 101, 111 is attached to the connection port 40 of the cradle 30). As a result, the medicinal liquid administration devices 100, 110 can appropriately control the fluid connection between the liquid delivery port 16 and the connection port 40 depending on whether the device main body 101, 111 and the cradle 30 are attached or not.

[0076] Furthermore, in the drug solution administration devices 100 and 110 according to this embodiment, the first housing portion 423 comprises an inner cavity 423a, a first communication hole 423b communicating with one end of the inner cavity 423a and into which the liquid delivery port 16 is attached, and a second communication hole 423c communicating with the other end of the inner cavity 423a and capable of communicating with the drug solution introduction portion 421, and the connection port 40 comprises a support portion 424 that supports the first housing portion 423 rotatably relative to the drug solution introduction portion 421, and the connection port 40 may be configured such that, with the liquid delivery port 16 attached to the first housing portion 423, the second communication hole 423c communicates with the drug solution introduction portion 421 and is fluidly connected to the liquid delivery port 16 by rotating the support portion 424 in a predetermined direction.

[0077] With the medicinal liquid administration devices 100, 110 configured in this manner, the user can easily fluidly connect the liquid delivery port 16 and the connection port 40 by attaching the liquid delivery port 16 to the first housing portion 423 and rotating the support portion 424 in a predetermined direction.

[0078] Furthermore, in the drug solution administration devices 100 and 110 according to this embodiment, the drug solution introduction portion 421 is provided with a hollow cylindrical stopper body 421b that can communicate with the second communication hole 423c, and the first housing portion 423 further has a sealing portion 423d at the base end side that tightly contacts the cylindrical stopper body 421b to block the drug solution introduction portion, and is configured to be rotatable by the support portion 424 between an open position for fluidly connecting the liquid delivery port 16 and the connection port 40 and a closed position for blocking the fluid connection between the liquid delivery port 16 and the connection port 40, and the connection port 40 may be configured so that when the support portion 424 is rotated with the liquid delivery port 16 attached to the first housing portion 423 and the first housing portion 423 is moved to the closed position, the cylindrical stopper body 421b and the sealing portion 423d tightly contact each other to block the fluid connection with the liquid delivery port 16.

[0079] With the thus configured drug solution administration devices 100, 110, the user can attach the liquid delivery port 16 to the first housing portion 423 and then rotate the support portion 424 so that the first housing portion 423 moves to the closed position, thereby causing the sealing portion 423d to adhere tightly to the tubular stopper body 421b, easily blocking the fluid connection between the liquid delivery port 16 and the connection port 40.

[0080] In the drug solution administration device 110 according to this embodiment, the support portion 424 may be configured to include a biasing member 424c that biases the first housing portion 423 toward the closed position.

[0081] In the drug solution administration device 110 configured in this manner, the support part 424 is provided with a biasing member 424c that biases the first housing part 423 toward the closed position, and therefore, after the device main body 111 is detached from the cradle 30, the first housing part 423 can be moved from the open position to the closed position by the biasing force of the biasing member 424c. Therefore, even when the device main body 111 is not attached to the cradle 30, the connection port 40 is always blocked from communication with the outside, and the internal space 45 can be kept sealed.

[0082] In addition, in the drug solution administration devices 100, 110 of this embodiment, the first housing portion 423 may be configured to have a first seal portion 422 that is in close contact with the outer surface of the attached liquid delivery port 16 near the first communication hole 423b in the inner cavity 423a.

[0083] According to the thus configured medicinal liquid administration devices 100, 110, the first sealing portion 422 is in close contact with the outer periphery of the tip of the liquid delivery port 16 attached to the first communicating hole 423b, thereby improving the liquid-tightness when the liquid delivery port 16 and the first housing portion 423 are connected.

[0084] This application is based on Japanese Patent Application No. 2021-050937, filed on March 25, 2021, the disclosure of which is incorporated by reference in its entirety. [Explanation of symbols]

[0085] 10 first body portion, 12 reservoirs, 14. Fluid delivery tube, 16 fluid transfer ports, 20 second body portion, 23 liquid delivery drive unit, 30 cradles, 40 connection ports, 42 first connecting portion (421 drug solution introducing portion, 421b cylindrical plug body, 422 first sealing portion, 423 first housing portion, 423a inner cavity of first housing portion, 423b first communicating hole, 423c second communicating hole, 423d sealing portion, 424 support portion, 424c urging member), 43 second connection part, 50 cannulae, 100, 110 Drug administration device; 101, 111 device body (101a bottom part), D1 mounting direction, D2 Departure direction.

Claims

1. a cradle having a connection port for holding a cannula to be inserted into a living body; a device body including a reservoir for storing a liquid medicine, a liquid delivery drive unit for delivering the liquid medicine from the reservoir, a liquid delivery tube through which the liquid medicine delivered from the reservoir flows, and a hollow cylindrical liquid delivery port communicating with the liquid delivery tube; A drug solution administration device in which the liquid delivery port and the connection port are detachably fluidly connected, the connection port includes a liquid medicine introduction section that introduces the liquid medicine delivered from the liquid delivery tube, and a first housing section that has the liquid delivery port attached thereto and is movably attached relative to the liquid medicine introduction section, A drug solution administration device, wherein the first housing portion is movable relative to the drug solution introduction portion between an open position for fluidly connecting the liquid delivery port and the connection port and a closed position for blocking the fluid connection between the liquid delivery port and the connection port.

2. the first housing portion includes a cavity, a first communication hole that communicates with one end of the cavity and to which the liquid delivery port is attached, and a second communication hole that communicates with the other end of the cavity and can communicate with the drug solution introduction portion, the connection port includes a support portion coupled to the first housing portion and supporting the first housing portion rotatably relative to the drug solution introducing portion; The drug solution administration device of claim 1, wherein the connection port is fluidly connected to the drug solution delivery port by rotating the support portion in a predetermined direction while the drug solution delivery port is attached to the first housing portion, so that the second communication hole communicates with the drug solution introduction portion and is fluidly connected to the drug solution delivery port.

3. the drug solution introduction section includes a hollow cylindrical plug that can communicate with the second communication hole, the first housing portion further includes a sealing portion on a base end side thereof that comes into close contact with the cylindrical plug body to close the drug solution introduction portion, and is configured to be rotatable by the support portion between the open position and the closed position, The drug solution administration device of claim 2, wherein when the support portion is rotated and the first housing portion is moved to the closed position with the liquid delivery port attached to the first housing portion, the tubular stopper body and the sealing portion come into close contact with each other, thereby cutting off the fluid connection with the liquid delivery port.

4. The drug solution administration device according to claim 3 , wherein the support portion includes a biasing member that biases the first housing portion toward the closed position.

5. A drug solution administration device as described in any one of claims 2 to 4, wherein the first housing portion is provided with a first seal portion that is in close contact with the outer surface of the attached liquid delivery port near the first communicating hole in the inner cavity.

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