Allergen-blocking gel

Abstract

To provide a nasal application agent for suppressing allergic reactions of the human body caused by water-soluble allergens.SOLUTION: A first step I comprises mixing and stirring Vaseline with a vegetable oil, and a first step II comprises mixing and stirring a sugar alcohol such as mannitol with a thickener such as finely powdered cellulose. In a second step after the first steps I and II, a gel I comprising the stirred Vaseline and vegetable oil such as olive oil, and a gel II comprising the stirred sugar alcohol and thickener are mixed and stirred together. The resulting gel has both hydrophilic and hydrophobic properties, and the allergen-blocking gel for nasal application has an effective molar osmotic pressure higher than that of body fluids, i.e., 330 mOsm / L or more. Furthermore, by adding a herb oil from the Lamiaceae family, the allergen-blocking gel can also provide "refreshing nasal sensation and, by the herb oil from the Lamiaceae family, alleviated inflammation of the nasal mucosa".SELECTED DRAWING: Figure 1

Description

[Technical Field]

[0001] This relates to means for suppressing allergies caused by water-soluble proteins in house dust and pollen. [Background technology]

[0002] There are antihistamines that suppress allergic reactions such as hay fever, and an allergen treatment device that I have applied for. [Prior art documents] [Patent documents]

[0003] [Patent Document 1] Patent No. 11-118446 [Patent Document 2] Patent Heisei 11-217703 [Non-patent literature]

[0004] [Non-Patent Document 1] The allergen treatment device I applied for was later commercialized as a treatment device that is inserted into both nasal passages to suppress allergic reactions. Allergen blocking agents are also sold at drugstores, but there are also ointments made primarily of wax and petrolatum that simply prevent the entry of allergens. [Non-Patent Document 1] Summary of the Invention [Problem to be solved by the invention]

[0005] Every spring, pollen disperses, causing suffering for allergic rhinitis sufferers. Recently, I believe that an increasing number of people are suffering from rhinitis not only due to pollen but also due to water-soluble allergens, such as house dust mites and other dead bodies. Allergic rhinitis sufferers often visit their doctor, but the medications prescribed are symptomatic antihistamines, not curatives, and must be taken annually. Drugstores also sell allergen-blocking agents, including topical ointments made primarily of wax and petrolatum that simply prevent the entry of allergens. These are primarily petrolatum-based and gel-based products. Petrolatum-based products do not blend well with mucous membranes, while gel-based products blend well but only temporarily block inflammation. [Means for solving the problem]

[0006] To block water-soluble allergens that enter through the mucous membranes of the nasal cavity or eyes, the allergen-blocking gel must have a higher osmolality than the osmolality of bodily fluids in order to prevent penetration. Therefore, the gel utilizes the difference in osmolality to "block using the osmotic pressure difference" with sugar alcohols such as "mannitol," which have a higher osmolality than the human body. The gel also "blocks" water-soluble allergens, such as pollen and house dust, with hydrophobic petrolatum and oils. Furthermore, aroma oils from the Lamiaceae family, such as mint, are added to the gel. [Effects of the Invention]

[0007] Those with allergic rhinitis often endure the painful experience of repeatedly blowing their noses during pollen season. This product offers a "two-blocking effect": the osmotic pressure difference blocks the entry of water-soluble allergens, while the hydrophobic effect of petrolatum and vegetable oil blocks water-soluble allergens. To soothe inflammation in the nose and eyelids, aromatic mint oil and peppermint oil, both of which are Lamiaceae herbs, can also produce a "relaxing effect." This invention also prevents the harmful effects of antihistamines, which suppress the immune system, and reduces the need to blow your nose repeatedly at night, allowing for better sleep. Furthermore, mint and other Lamiaceae members can also soothe inflammation of the nasal mucosa. [Brief explanation of the drawings]

[0008] [Figure 1] Explaining the mixing process of Example 1 [Figure 2] Example 2 is an illustration of the addition of herb oils according to claims 2 and 3. [Figure 3] Example 3 is an illustration of the addition of NaCl to the bill. [Figure 4] Example 4 is an explanatory diagram of the seal according to claim 4. [Figure 5] Example 7 is an explanatory diagram of a container for nasal allergen blocking gel according to claim 8. DETAILED DESCRIPTION OF THE INVENTION

[0009] [Example]

[0010] This invention is a nasal liniment for suppressing allergic reactions caused by water-soluble allergens in the human body. It involves a first step A of mixing petrolatum and a vegetable oil such as olive oil, and a first step B of mixing a sugar alcohol such as mannitol with a thickener such as finely powdered cellulose, followed by a second step of mixing two gels, Gel I of the mixed petrolatum and vegetable oil and Gel II of the mixed sugar alcohol and thickener, and mixing them together. The resulting gel has both hydrophilic and hydrophobic properties, and the allergen-blocking gel is more concentrated than body fluids, with an effective molar concentration of 0.033 mol / L or more, preventing the allergen from entering the nasal mucosa due to the "difference in osmotic pressure between the water-soluble allergen and the allergen-blocking gel" and the mixed petrolatum and vegetable oil Gel I "blocking the water-soluble allergen due to its hydrophobicity." FIG. 1 is an explanatory diagram of this embodiment. [Example]

[0011] Menthol or mint oil or peppermint oil, a Labiatae herbal oil, is added to the nasal allergen blocking gel at a ratio of 0.01 to 1 per 100 parts of allergen blocking gel. The menthol or herbal oil is added in the first step A, where it is added to the petrolatum and vegetable oil and mixed together. The oil is added in step A because it is the same oil as the petrolatum and vegetable oil in step A, making it easy to blend. Furthermore, the "Lamia herbal oil relieves inflammation of the nasal mucosa." Figure 2 is an explanatory diagram of the content of claims 2 and 3, which show the addition of menthol and Labiatae herbal oil. [Example]

[0012] Sodium chloride (NaCI) is added to 100 parts of allergen-blocking gel at a ratio of 0.5 to 3 parts per 100 parts of gel to create a gel specifically for the nasal cavity. The sodium chloride is dissolved and mixed in during the sugar alcohol and finely powdered cellulose process in step II. NaCI (0.154 mol / L) has a high effective molarity, similar to mannitol (0.4 mol / L). Since the molarity of body fluids is 0.031 mol / L, the gel has a higher molarity than body fluids. The difference in osmotic pressure prevents water-soluble allergens from penetrating the mucous membranes. Figure 3 is an explanatory diagram of this solution. [Example]

[0013] Use the viscosity of the allergen blocking gel within the range of 300 to 30,000 mpa. The viscosity of 30,000 mpa is best for nasal allergen blocking gel, and the viscosity of 300 mpa is best for eyelid allergen blocking gel. [Example]

[0014] The sticker (1) contains a gel made by adding menthol or mint family herbal oil to 100 parts of allergen blocking gel at a ratio of 0.003 to 0.01 per 100 parts of allergen blocking gel for the eyelids, and is applied to the lower eyelids.The amount of oil used for this product is less than that added to the allergen blocking gel for the nasal cavity, because the mucous membrane of the eyelids is more sensitive than the mucous membrane of the nasal cavity. FIG. 4 is an explanatory diagram of a sticker (1) containing gel according to claim 5 being applied to the lower eyelid. [Example]

[0015] This is a container for allergen-blocking gel for nasal passages, and the nozzle at the tip of the container has a soft silicone spatula-shaped tip (3) in front of the two outlets (2) on the front and back from which the gel comes out. By pressing the bottom of the container, the allergen-blocking gel comes out from the outlet (2), so by inserting the spatula (3) into the nasal passage and pressing it left and right, the allergen-blocking gel can be applied to the mucous membrane of the nasal passage. FIG. 5 is an explanatory diagram of an allergen-blocking gel container. [Industrial Applicability]

[0016] This product can suppress allergen reactions caused by water-soluble allergens without the use of antihistamines. [Explanation of symbols]

[0017] (1) Seal (2) Two outlets (3) Spatula

Claims

1. This allergen blocking gel is an allergen blocking gel for nasal application to suppress allergic reactions in the human body, and is characterized in that it is an allergen blocking gel for nasal application, which is produced by performing a first step A of mixing petrolatum and vegetable oil together and mixing it, and a first step B of mixing a sugar alcohol and a thickener together, followed by a second step of mixing two gels, Gel I of the mixed petrolatum and vegetable oil and Gel II of the mixed sugar alcohol and thickener together and mixing them to form a gel, which has hydrophobic and hydrophilic properties and is an allergen blocking gel for nasal application with an effective molar concentration of 0.033 mol / L or more, which is stronger than body fluids.

2. 2. The allergen blocking gel according to claim 1, further comprising a trace amount of menthol.

3. The allergen blocking gel according to claim 1, characterized in that mint oil or peppermint oil, a herbal oil of the Lamiaceae family, is added in a ratio of 0.01 to 1 per 100 parts of the allergen blocking gel, for use exclusively with the nasal cavity.

4. An allergen blocking gel according to any one of claims 1, 2, and 3, characterized in that sodium chloride NaCI is added to 100 parts of the allergen blocking gel in a ratio of 0.5 to 3 parts, making it suitable for use exclusively in the nasal cavity.

5. The allergen blocking gel according to claim 1, characterized in that the seal (1) containing a gel in which mint oil, peppermint oil or other herbal oil of the Lamiaceae family is added at a ratio of 0.003 to 0.01 per 100 parts of allergen blocking gel is applied to the lower eyelid.

6. The allergen blocking gel according to any one of claims 1 to 5, characterized in that the viscosity of the allergen blocking gel is within the range of 300 mPa.s to 30,000 mPa.s.

7. An allergen blocking gel as described in any one of claims 1, 2, 3, 5 and 6, which is a container for an allergen blocking gel for the nasal cavity, characterized in that the shape of the nozzle at the tip of the container has a soft silicone spatula-shaped (3) shape beyond the two outlets (2) on the front and back of the gel.

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