Nest with movable protrusions for pharmaceutical containers

Abstract

To provide a nest with movable protrusions for pharmaceutical containers.SOLUTION: A structure comprises a plurality of receptacles, in which a. the receptacles are adapted and arranged for receiving a plurality of containers, and b. each receptacle of the plurality of receptacles includes a sidewall defining an interior of the receptacle, where i. at least one protrusion is arranged on the sidewall and extends into the interior of the receptacle, and ii. the at least one protrusion has a first end and another end, where A. the first end is arranged opposite the other end, and B. the first end is attached to the sidewall, and where at least one section of the other end of the at least one protrusion is adapted and arranged to be movable with respect to the sidewall on which the protrusion is arranged.SELECTED DRAWING: Figure 1

Description

[Technical Field]

[0001] The present invention relates to a structure for receiving and transporting a plurality of containers, said containers preferably for holding pharmaceutical and / or cosmetic compositions. The present invention also relates to the use of the structure during filling of a plurality of containers received within the structure. The present invention also relates to the use of the structure for transporting a plurality of containers.

[0002] Background technology Containers, such as those for pharmaceutical and / or cosmetic compositions, are commonly received (held) and transported using structures known as nests (such as those commercially available from SCHOTT Pharma AG & Co. KGaA). The containers often have varying diameters. For example, the containers may be syringes with caps, where the barrels of the syringes have a smaller diameter compared to the diameter of the caps. Therefore, the receptacles within the nests must be sized so that containers with varying diameters can still be accommodated within the nests. However, this often results in a relatively large gap between the barrels and the receptacle sidewalls, causing the containers to tilt within the nests. Such tilting often leads to contact between the containers (e.g., between the flanges of the syringes), which often causes damage to the containers. Furthermore, tilting of the containers commonly leads to problems during filling of the containers with the composition. These problems include variations in the fill height of the composition and contact between the containers and the needles used to fill the containers. Such contact can damage the containers as well as the filling needles. A further problem associated with nests known from the prior art is that the high packing density of the containers leads to contact between the containers and damage to the containers. Prior art nests also generally have a large contact surface between the side walls of the receptacle and the containers received in said receptacle. This leads to the formation of undesirable particles on the surfaces of the containers.

[0003] Summary of the Invention The object of the present invention is to at least partially overcome at least one of the drawbacks encountered in the state of the art.

[0004] It is a further object of the present invention to provide a structure for receiving a plurality of containers, preferably for housing pharmaceutical and / or cosmetic compositions, said structure allowing for a higher packing density of said containers within the structure.

[0005] It is a further object of the present invention to provide a structure for receiving a plurality of containers, preferably for holding pharmaceutical and / or cosmetic compositions, said structure reducing tilting of the containers when they are received within the structure.

[0006] A further object of the present invention is to provide a structure for receiving multiple containers, preferably for housing pharmaceutical and / or cosmetic compositions, in which damage to the containers is reduced when said containers are inserted into and / or removed from the structure.

[0007] It is a further object of the present invention to provide a structure for receiving multiple containers, preferably for housing pharmaceutical and / or cosmetic compositions, which structure allows for easier removal of the containers from the structure.

[0008] It is a further object of the present invention to provide a structure for receiving a plurality of containers, preferably for housing pharmaceutical and / or cosmetic compositions, which structure allows for a reduction in damage to said structure during insertion of the containers into the structure.

[0009] It is a further object of the present invention to provide a structure for receiving multiple containers, preferably for holding pharmaceutical and / or cosmetic compositions, in which damage to the containers is reduced when the containers are received within the structure (e.g., during transport of the containers using the structure).

[0010] It is a further object of the present invention to provide a structure for receiving a plurality of containers, preferably for housing pharmaceutical and / or cosmetic compositions, which structure allows for a reduction in the variation in the volume of the compositions within said containers.

[0011] It is a further object of the present invention to provide a structure for receiving a plurality of containers, preferably for holding pharmaceutical and / or cosmetic compositions, which structure allows for reduced downtime of equipment used for at least one or all of inserting the containers into the structure, filling the containers received in the structure, and removing the containers from the structure.

[0012] It is a further object of the present invention to provide a structure for receiving a plurality of containers, preferably for containing pharmaceutical and / or cosmetic compositions, in which damage to the containers and / or components used to fill said containers is reduced during filling of said containers.

[0013] It is a further object of the present invention to provide a structure for receiving a plurality of containers, preferably for containing pharmaceutical and / or cosmetic compositions, said structure reducing particle formation on the surfaces of said containers when received within the structure.

[0014] It is a further object of the present invention to provide a structure for receiving a plurality of containers, preferably for containing pharmaceutical and / or cosmetic compositions, said containers having different diameters.

[0015] Means to solve the problem Contributions to at least partially meeting at least one of the above-mentioned objectives are made by any of the embodiments of the present invention.

[0016] A first embodiment of the present invention is a structure comprising a plurality of receptacles, a. the receptacle is adapted and arranged to receive a plurality of containers, the containers preferably for containing pharmaceutical and / or cosmetic compositions; b. each receptacle of the plurality of receptacles includes a sidewall defining an interior of the respective receptacle; i. at least one protrusion disposed on the side wall and extending into the interior of each receptacle; ii. at least one protrusion has a first end and another end; A. a first end is disposed opposite another end; B. the first end is attached to the side wall; At least one section of the other end of the at least one projection is a structure adapted and arranged to be movable relative to the sidewall on which said projection is disposed.

[0017] In a preferred aspect of the first embodiment, the receptacle is adapted and arranged to receive a plurality of containers, each of the plurality of containers having a first section and another section, the diameter of the another section being larger than the diameter of the first section. In this aspect, the another section is preferably the body of the container, and the another section is preferably a closure adapted and arranged to close the container. In this aspect, the first section is preferably the barrel of a syringe, and the another section is preferably the cap of the syringe.

[0018] In a preferred embodiment of the present structure, at least a segment, preferably at least one section, of at least one projection is adapted and arranged to be deformable, preferably elastically deformable.

[0019] This preferred embodiment is a second embodiment of the present invention, which is preferably dependent on the first embodiment of the present invention.

[0020] In a preferred embodiment of the structure, at least one section of the other end is adapted and arranged to rotate through an angle in the range of -90° to 90°, preferably -75° to 75°, and more preferably -60° to 60°.

[0021] This preferred embodiment is a third embodiment of the present invention, which is preferably dependent on any of the first and second embodiments of the present invention.

[0022] In a preferred embodiment of the present structure, at least one protrusion is adapted and arranged to rotate about the first end of the protrusion.

[0023] This preferred embodiment is a fourth embodiment of the present invention, which is preferably dependent on any of the first to third embodiments of the present invention. An example of the fourth embodiment is a protrusion whose first end forms a hinge.

[0024] In a preferred embodiment of the present structure, the first end of the at least one projection is adapted and arranged to form a hinge.

[0025] This preferred embodiment is a fifth embodiment of the present invention, which is preferably dependent on any of the first to fourth embodiments of the present invention.

[0026] In a preferred embodiment of the present structure, at least one protrusion comprises a polymer selected from the group consisting of polypropylene, polyoxymethylene, polyethylene, polyethylene terephthalate, polyamide, polycarbonate, cycloolefin copolymer (COC) and cycloolefin polymer (COP).

[0027] This preferred embodiment is a sixth embodiment of the present invention, which is preferably dependent on any of the first to fifth embodiments of the present invention. In the sixth embodiment, polypropylene is particularly preferred.

[0028] In a preferred embodiment of the structure, the force required to remove a container from each receptacle is equal to or less than the weight of the structure, preferably less than the weight of the structure.

[0029] This preferred embodiment is a seventh embodiment of the present invention, which is preferably dependent on any of the first to sixth embodiments of the present invention.

[0030] In a preferred embodiment of this construction, the force required to remove the container from each receptacle is 1N or less, preferably 0.5N or less, more preferably 0.1N or less, and even more preferably 0.075N or less.

[0031] This preferred embodiment is an eighth embodiment of the present invention, which is preferably dependent on any of the first to seventh embodiments of the present invention.

[0032] In a preferred embodiment of the present structure, at least one protrusion has an elastic modulus in the range of 0.80 to 3.50 GPa, preferably 0.85 to 3.30 GPa, more preferably 0.90 to 3.15 GPa, and even more preferably 0.95 to 3.00 GPa.

[0033] This preferred embodiment is a ninth embodiment of the present invention, which is preferably dependent on any of the first to eighth embodiments of the present invention.

[0034] In a preferred embodiment of this structure, each receptacle has a first end and another end, and at least one protrusion is located closer to the other end of each receptacle than to the first end.

[0035] This preferred embodiment is a tenth embodiment of the present invention, which is preferably dependent on any of the first to ninth embodiments of the present invention.

[0036] In a preferred embodiment of this structure, each receptacle has a first end and another end, and at least one protrusion is disposed at a distance x1L from the other end of each receptacle, where L is the length of each receptacle, and x1 is in the range of 0 to 0.5, preferably 0 to 0.4, more preferably 0 to 0.3, and even more preferably 0 to 0.2.

[0037] This preferred embodiment is an eleventh embodiment of the present invention, preferably dependent on any of the first to tenth embodiments of the present invention. In a preferred aspect of the eleventh embodiment, at least one protrusion is located at another end of each receptacle (i.e., x1=0).

[0038] In a preferred embodiment of this structure, each receptacle has a first end and another end, and at least one protrusion is located at a distance from the other end, the distance being in the range of 0 to 8.75 mm, preferably 0 to 7.00 mm, more preferably 0 to 5.25 mm, and even more preferably 0 to 3.5 mm.

[0039] This preferred embodiment is a twelfth embodiment of the present invention, which is preferably dependent on any of the first to eleventh embodiments of the present invention.

[0040] In a preferred embodiment of the present structure, the distance that the at least one protrusion extends into the interior of the respective receptacle is greater than the maximum thickness of the at least one protrusion.

[0041] This preferred embodiment is a thirteenth embodiment of the present invention, which is preferably dependent on any of the first to twelfth embodiments of the present invention.

[0042] In a preferred embodiment of the present structure, at least one protrusion is spaced from the interior volume of the respective receptacle by a distance yD MIN where D MINis the minimum diameter of each receptacle, where y is in the range of 0.015 to 0.3, preferably 0.05 to 0.28, more preferably 0.1 to 0.27, and even more preferably 0.2 to 0.26.

[0043] This preferred embodiment is a fourteenth embodiment of the present invention, which is preferably dependent on any of the first to thirteenth embodiments of the present invention.

[0044] In a preferred embodiment of the present structure, the distance that the at least one projection extends into the interior of the respective receptacle is in the range of 0.1 to 9 mm, preferably 0.3 to 7 mm, even more preferably 0.4 to 6 mm, and even more preferably 0.5 to 5 mm.

[0045] This preferred embodiment is a fifteenth embodiment of the present invention, which is preferably dependent on any of the first to fourteenth embodiments of the present invention.

[0046] In a preferred embodiment of this structure, the maximum thickness of at least one protrusion is in the range of 0.05 mm to 4 mm, preferably 0.1 to 3 mm, more preferably 0.15 to 2.5 mm, and even more preferably 0.2 to 2.1 mm.

[0047] This preferred embodiment is a 16th embodiment of the present invention, which is preferably dependent on any of the 1 to 15 embodiments of the present invention. In a preferred aspect of the 16th embodiment, the at least one protrusion has a maximum thickness at a first end of the at least one protrusion.

[0048] In a preferred embodiment of the present structure, the ratio of the width of the at least one protrusion to the circumference C of the respective receptacle is 0.5C or less, preferably 0.25C or less, and more preferably 0.1C or less.

[0049] This preferred embodiment is a 17th embodiment of the present invention, which is preferably dependent on any of the first to sixteenth embodiments of the present invention.

[0050] In a preferred embodiment of the present structure, at least one protrusion has a width that is 6 mm or less, preferably 5.5 mm or less, more preferably 5 mm or less, and even more preferably 4.5 mm or less.

[0051] This preferred embodiment is an 18th embodiment of the present invention, which is preferably dependent on any of the first to seventeenth embodiments of the present invention. In a preferred aspect of the 18th embodiment, the width is in the range of 0.05 to 6 mm, preferably 0.1 to 5 mm, and more preferably 0.15 to 4.5 mm.

[0052] In a preferred embodiment of the present structure, the length of at least one protrusion is measured between a first end and another end of said protrusion, and the thickness of at least one protrusion measured at the first end is different from the thickness of the protrusion measured at the other end.

[0053] This preferred embodiment is a 19th embodiment of the present invention, preferably dependent on any of the first to eighteenth embodiments of the present invention. In a preferred aspect of the 19th embodiment, the thickness decreases from the first end to the other end. In a preferred aspect of the 19th embodiment, the thickness measured at the first end varies from the thickness measured at the other end by at least 10%, more preferably at least 30%, even more preferably at least 50%, and even more preferably at least 70%. In a preferred aspect of the 19th embodiment, the thickness measured at the first end varies from the thickness measured at the other end by less than 150%, more preferably less than 130%, even more preferably less than 110%, and even more preferably less than 100%. In a preferred aspect of the 19th embodiment, the thickness at the first end is 2 mm or less, more preferably 1.8 mm or less, and even more preferably 1.6 mm or less. In this aspect, the thickness at the other end is preferably 0.2 mm.

[0054] In a preferred embodiment of the present structure, the length of at least one protrusion is measured between a first end and another end of said protrusion, and the thickness of the at least one protrusion varies by less than 10%, preferably less than 5%, and more preferably less than 3% along the length of the at least one protrusion.

[0055] This preferred embodiment is a twentieth embodiment of the present invention, which is preferably dependent on any of the first to nineteenth embodiments of the present invention.

[0056] In a preferred embodiment of the present structure, the geometric shape of at least one portion of at least one protrusion is selected from the group consisting of a flap, a curved surface, and a pin.

[0057] This preferred embodiment is a 21st embodiment of the present invention, which is preferably dependent on any of the first to 20th embodiments of the present invention.

[0058] In a preferred embodiment of the present structure, the at least one protrusion is adapted and arranged to create a gap between a first segment of the side wall and a first segment of the container when the container is received (e.g., held) in the respective receptacle.

[0059] This preferred embodiment is a 22nd embodiment of the present invention, preferably dependent on any of the 1st to 21st embodiments of the present invention. In a preferred aspect of the 22nd embodiment, at least one protrusion is adapted and arranged to create said gap at least at another end of the respective receptacle.

[0060] In a preferred embodiment of this structure, each receptacle comprises at least two protrusions, more preferably at least three protrusions, and even more preferably three protrusions.

[0061] This preferred embodiment is a 23rd embodiment of the present invention, which is preferably dependent on any of the first to 22nd embodiments of the present invention.

[0062] In a preferred embodiment of the structure, each receptacle comprises a first set of protrusions, said protrusions being arranged in positions that vary by less than 10%, preferably less than 7.5%, and more preferably less than 5% when measured parallel to another direction.

[0063] This preferred embodiment is a 24th embodiment of the present invention, which is preferably dependent on any of the first to 23rd embodiments of the present invention.

[0064] In a preferred embodiment of the present structure, the first set of protrusions comprises at least one protrusion, preferably at least two protrusions, more preferably at least three protrusions, and even more preferably three protrusions.

[0065] This preferred embodiment is a 25th embodiment of the present invention, which is preferably dependent on the 24th embodiment of the present invention.

[0066] In a preferred embodiment of this structure, a. each receptacle has at least one separate set of protrusions; b. The first set is positioned a distance from the other set.

[0067] This preferred embodiment is a 26th embodiment of the present invention, preferably dependent on any of the 24th to 25th embodiments of the present invention. In the 26th embodiment, the distance is measured parallel to the other direction based on an average position of the protrusions of the set. In a preferred aspect of the 26th embodiment, the other set of protrusions comprises at least two protrusions, more preferably at least three protrusions, and even more preferably three protrusions. In the 26th embodiment, when the other set comprises at least two protrusions, the protrusions are positioned at positions that vary by less than 10%, preferably less than 7.5%, and even more preferably less than 5% when measured parallel to the other direction.

[0068] In a preferred embodiment of the present structure, each receptacle has a first end and another end; a. a first set of protrusions is located closer to the other end than to the first end; b. another set of at least one protrusion is located closer to the first end than to the other end; At least one or all of the following applies:

[0069] This preferred embodiment is a 27th embodiment of the present invention, which is preferably dependent on the 26th embodiment of the present invention. In one aspect of the 27th embodiment, all possible combinations of feature a and feature b are preferred aspects of the embodiment. These combinations are, for example, a; b; a + b.

[0070] In a preferred embodiment of the present structure, each receptacle has a first end and another end; a. a first set of protrusions is positioned a distance x1L from another end of each receptacle, where L is the length of each receptacle and x1 is in the range of 0 to 0.5, preferably 0 to 0.4, more preferably 0 to 0.3, and even more preferably 0 to 0.2; b. another set of at least one protrusion is positioned at a distance x2L from the first end of each receptacle, where L is the length of each receptacle and x2 is in the range of 0 to less than 0.5, preferably 0 to 0.4, more preferably 0 to 0.3, and even more preferably 0 to 0.2; At least one or all of the following applies:

[0071] This preferred embodiment is a 28th embodiment of the present invention, which is preferably dependent on any of the 26th to 27th embodiments of the present invention. In one aspect of the 28th embodiment, all possible combinations of feature a and feature b are preferred aspects of the embodiment. These combinations are, for example, a; b; a + b.

[0072] In a preferred embodiment of this structure, the sidewall of each receptacle has at least one section with a curved surface, the at least one section forming at least one ridge that extends into the interior of the respective receptacle.

[0073] This preferred embodiment is a 29th embodiment of the present invention, which is preferably dependent on any of the 1st to 28th embodiments of the present invention.

[0074] In a preferred embodiment of the present structure, each receptacle comprises at least two ridges, with at least one protrusion disposed between the at least two ridges.

[0075] This preferred embodiment is a 30th embodiment of the present invention, which is preferably dependent on the 29th embodiment of the present invention. In a preferred aspect of the 30th embodiment, when each receptacle comprises two or more protrusions, each protrusion is disposed between two ridges.

[0076] In preferred embodiments of the present structure, at least one ridge extends along at least 5%, preferably at least 10%, more preferably at least 25%, and even more preferably at least 50% of the length of each receptacle.

[0077] This preferred embodiment is a 31st embodiment of the present invention, which is preferably dependent on any of the 29th to 30th embodiments of the present invention.

[0078] In a preferred embodiment of the present structure, each receptacle comprises at least two, preferably at least four, more preferably at least six ridges.

[0079] This preferred embodiment is the 32nd embodiment of the present invention, which is preferably dependent on any of the 29th to 31st embodiments of the present invention.

[0080] In a preferred embodiment of this structure, the internal diameter varies along the length of each receptacle, and preferably a first internal diameter measured at a first end of each receptacle is greater than another internal diameter measured at another end of each receptacle.

[0081] This preferred embodiment is a 33rd embodiment of the present invention, which is preferably dependent on any of the first to 32nd embodiments of the present invention.

[0082] In a preferred embodiment of the structure, the structure further comprises a plurality of containers containing less than 0.1 ml, preferably less than 0.05 ml, and more preferably less than 0.01 ml of composition.

[0083] This preferred embodiment is a 34th embodiment of the present invention, which is preferably dependent on any of the 1st to 33rd embodiments of the present invention.

[0084] In a preferred embodiment of the structure, the structure further comprises a plurality of containers that are at least 20%, preferably at least 35%, more preferably at least 50% filled with the composition, said percentages being relative to the internal volume of the container.

[0085] This preferred embodiment is a 35th embodiment of the present invention, which is preferably dependent on any of the first to 34th embodiments of the present invention.

[0086] In a preferred embodiment of the present structure, each container of the plurality of containers has a first section and another section, the diameter of the another section being larger than the diameter of the first section.

[0087] This preferred embodiment is a 36th embodiment of the present invention, which is preferably dependent on the 35th embodiment of the present invention. In a preferred aspect of the 36th embodiment, the separate section is a body of a container and the separate section is a closure adapted and arranged to close the container. In a preferred aspect of the 36th embodiment, the first section is a barrel of a syringe and the separate section is a cap of the syringe.

[0088] A 37 embodiment of the present invention is a method for at least partially filling a plurality of containers with a composition, preferably a pharmaceutical and / or cosmetic composition, comprising the steps of: a. Providing a structure according to the present invention, preferably a structure according to any of the first to thirty-third embodiments of the present invention; b. Inserting a plurality of containers into a plurality of receptacles of the structure, wherein at least one protrusion preferably deforms during said insertion, and the containers preferably are according to any of the 34th to 36th embodiments of the present invention; c. at least partially filling the container with the composition; The method includes:

[0089] In a preferred aspect of the thirty-seventh embodiment, each container of the plurality of containers has a first section and another section, the diameter of the another section being larger than the diameter of the first section. In this aspect, the another section is preferably the body of the container, and the another section is preferably a closure adapted and arranged to close the container. In this aspect, the first section is preferably the barrel of a syringe, and the another section is preferably the cap of the syringe.

[0090] In a preferred embodiment of the method for at least partially filling a plurality of containers with a composition, the method further comprises: d. Removing the plurality of containers from the structure, wherein at least one protrusion preferably deforms during said removal. Includes:

[0091] This preferred embodiment is the 38th embodiment of the present invention, which is preferably dependent on the 37th embodiment of the present invention.

[0092] A 39th embodiment of the present invention is a plurality of containers at least partially filled with a composition, obtainable by a method (according to the present invention) for filling a plurality of containers with a composition, preferably by a method according to any of the 37th to 38th embodiments of the present invention.

[0093] A 40th embodiment of the present invention is a method for transporting a plurality of containers, comprising the steps of: a. Providing a structure according to the present invention, preferably a structure according to any of the first to thirty-third embodiments of the present invention; b. Inserting a plurality of containers into the structure, the containers preferably being according to any of the 34th to 36th embodiments of the present invention; c. transporting the structure and the plurality of containers from the first location to another location; The method includes:

[0094] In a preferred aspect of the fortieth embodiment, each container of the plurality of containers has a first section and another section, the diameter of the another section being larger than the diameter of the first section. In this aspect, the another section is preferably the body of the container, and the another section is preferably a closure adapted and arranged to close the container. In this aspect, the first section is preferably the barrel of a syringe, and the another section is preferably the cap of the syringe.

[0095] In a preferred embodiment of the method for transporting a plurality of containers, the method comprises: A. Inserting the structure into yet another structure, e.g., a tab, that at least partially surrounds the structure; B. sealing the opening of the further structure with a film, preferably a gas permeable film; C. Sterilizing the structure and the container received therein, preferably while sealed within a further structure, e.g., a tub; and further comprising at least one or all of:

[0096] This preferred embodiment is a 41st embodiment of the present invention, which is preferably dependent on the 40th embodiment of the present invention. In one aspect of the 41st embodiment, all possible combinations of Features A to C are preferred aspects of the embodiment. These combinations are, for example, A; B; C; A+B; A+C; B+C; A+B+C. In the 41st embodiment, the "tab" should be understood as being used in the pharmaceutical industry. In a preferred aspect of the 41st embodiment, one or more of Steps A to C are performed at a first location, and one or more of Steps A to C are performed at another location. For example, Steps A and B are performed at a first location after performing Step B in the 40th embodiment, and then the structure with the container is transported to another location (Step C in the 40th embodiment), and then Step C is performed at the other location.

[0097] A 42nd embodiment of the present invention is a. reducing contact between a plurality of receptacles and a plurality of containers received within said receptacles, preferably reducing contact between the plurality of receptacles and another end of a plurality of containers received within said receptacles; b. Reducing contact between adjacent vessels housed within the structure; and c. Reducing particle counts on the surfaces of containers received within the structure; and d. Reducing damage to the container when it is received within the structure; and (b) use of a structure according to the present invention, preferably a structure according to any of the first to thirty-sixth embodiments of the present invention, to perform at least one or all of the following.

[0098] In one aspect of the forty-second embodiment, all possible combinations of features a through d are preferred aspects of the embodiment, such as a; b; c; d; a+b; a+c; a+d; b+c; b+d; c+d; a+b+c; a+b+d; a+c+d; b+c+d; a+b+c+d.

[0099] Detailed Description of the Invention Features described as preferred in one category of the invention, for example due to structure, are equally preferred in other categories of embodiments according to the invention, such as the use of the structure according to the invention.

[0100] Throughout this specification, disclosures of ranges should preferably be understood to include both endpoints of the range. Moreover, each disclosure of a range herein should preferably be understood to also disclose preferred subranges in which one endpoint or both endpoints are excluded. For example, the disclosure of a range from X1 to X2 should be understood to disclose a range inclusive of both endpoints X1 and X2. Furthermore, the disclosure of a range from X1 to X2 should be understood to also disclose ranges inclusive of endpoint X1 but excluding endpoint X2, ranges inclusive of endpoint X1 but including endpoint X2, and ranges excluding both endpoints X1 and X2.

[0101] Some preferred embodiments and aspects have various combinations of features as alternatives. Where various combinations are disclosed, these combinations are separated by semicolons (";"). For example, a list of preferred embodiments of features "a; a+b; a+c+d" discloses preferred embodiments including feature "a," preferred embodiments including features "a" and "b," and preferred embodiments including features "a," "c," and "d."

[0102] In one embodiment of the present invention, a structure "comprises a plurality of receptacles, each receptacle of the plurality of receptacles comprising a sidewall defining an interior of the respective receptacle, the sidewall comprising at least one protrusion disposed on the sidewall and extending into the interior of the respective receptacle, the at least one protrusion having a first end and another end, the first end disposed opposite the other end, the first end attached to the sidewall, and at least one section of the other end of the at least one protrusion adapted and arranged to be movable relative to the sidewall on which the protrusion is disposed." This should not be understood to mean that a structure can have only receptacles having protrusions with at least one section that is movable relative to the receptacle sidewall. In addition to the above-mentioned plurality of receptacles, the structure may further include, for example, another plurality of receptacles, the side walls of which do not include protrusions, or the protrusions of which do not include movable separate ends.

[0103] In one aspect of the invention, it is preferred that at least 70%, more preferably at least 85%, even more preferably at least 95%, and even more preferably all of the receptacles of the first structure form part of a plurality of receptacles (i.e., have a sidewall with at least one protrusion having at least one section that is movable relative to the receptacle sidewall). Preferred embodiments and aspects of "each receptacle" should be understood to be at least 70%, more preferably at least 85%, even more preferably at least 95%, and even more preferably all of the preferred embodiments and aspects of the receptacles that form the plurality of receptacles.

[0104] An example of a container received within a receptacle is a container held within said receptacle.

[0105] structure The structure preferably comprises a polymer. Examples of preferred polymers include polypropylene, polyoxymethylene, polyethylene, polyethylene terephthalate, polystyrene, cycloolefin copolymer (COC) and cycloolefin polymer (COP). Here, polypropylene is particularly preferred for the structure.

[0106] The structure may be obtained by deep drawing, preferably injection molding, and / or 3D printing. The structure is preferably manufactured as a single piece. A structure for receiving a container, said container being for containing a pharmaceutical composition and / or a cosmetic composition, is often called a "nest". Here, "nest" should preferably be understood as being used in the pharmaceutical industry.

[0107] The structure preferably includes 5 to 250, more preferably 10 to 200, even more preferably 20 to 190, even more preferably 40 to 180, even more preferably 60 to 180, even more preferably 80 to 180, even more preferably 100 to 160 receptacles.

[0108] The structure preferably has a mass in the range of 40 to 400 g, more preferably 55 to 250 g, and even more preferably 75 to 100 g.

[0109] In one preferred aspect of the invention, at least portions of the side walls of adjacent receptacles do not touch (e.g., a gap is formed between said portions). In another preferred aspect of the invention, the side walls of adjacent receptacles touch. In another preferred aspect of the invention, adjacent receptacles share at least a portion of the same side wall.

[0110] Receptacle The receptacles preferably extend from a first surface of the structure. Preferred receptacles are elongated. Preferred receptacles have a first end and another end opposite the first end. The first end of the receptacle preferably has a first opening for receiving a container. In other words, the receptacles are preferably adapted and arranged so that a container can be inserted into and / or removed from said respective receptacle at the first end. Preferably, the other end of the receptacle has another opening. The other opening at the other end of the receptacle is preferably adapted and arranged to allow a portion of the container to extend from the receptacle when said container is received within the receptacle.

[0111] protrusion The protrusions preferably comprise at least one thermoplastic material, and more preferably are made from at least one thermoplastic material. The cross-section of the protrusions can be of any geometric shape, said cross-section being perpendicular to the length of the protrusion. For example, if the protrusions are in the form of pins, said pins can have a cylindrical or rectangular cross-section.

[0112] In a preferred embodiment of the present invention, the protrusion is integrally formed with the side wall of the receptacle. In a preferred embodiment of the present invention, the protrusion extends in a direction that is substantially perpendicular to the side wall of the receptacle. In one preferred embodiment of the present invention, the protrusion and the side wall on which the protrusion is disposed are made of the same material. In another preferred embodiment of the present invention, the protrusion and the side wall on which the protrusion is disposed are made of different materials.

[0113] A set of protrusions should preferably be understood as one or more protrusions arranged in positions that vary by less than 10% when measured parallel to another direction. A set may include only one protrusion.

[0114] A protrusion having a geometric shape in the form of a flap should preferably be understood to mean that the protrusion includes at least one first portion, and the maximum width of the at least one first portion is greater than the maximum thickness of the at least one first portion. The protrusion may also include at least two of the aforementioned first portions, and the at least two aforementioned first portions may be arranged at an angle relative to each other. The protrusion may also include one or more other portions in the shape of a curved surface. The protrusion may also include two or more of the aforementioned other portions arranged at an angle relative to each other.

[0115] Movable and transformable A section of the other end of the projection adapted and arranged to be movable relative to the side wall of the receptacle should be understood to mean that the other end of said projection can move while the side wall on which the projection is arranged remains stationary.

[0116] A section of the other end of the protrusion adapted and arranged to be movable relative to the side wall of the receptacle should be understood to mean that said section can be moved without damaging the protrusion, an example of which would be breaking or tearing the other end of the protrusion.

[0117] A protrusion adapted and arranged to be deformable should preferably be understood to mean at least one or all of the following: when a force is applied to the protrusion, another end of the protrusion can move relative to the sidewall without breaking the protrusion; when a force is applied to the protrusion, the shape of the protrusion can be changed without breaking the protrusion. For example, the protrusion can be bent along its length when a container is inserted into the receptacle and contacts the protrusion.

[0118] A protrusion adapted and arranged to be elastically deformable should preferably be understood to be such that when no force is applied to the protrusion, the other end of the protrusion is in a first position (e.g., the protrusion is a straight pin). When a force is applied, the other end of the protrusion moves to another position (e.g., the pin is bent). When the force is removed, the other end of the protrusion at least partially returns to the first position (e.g., the protrusion becomes more straight but may still be bent).

[0119] force In the context of the present disclosure, the force applied to the protrusion should preferably be understood to have a magnitude of the same order of magnitude as the force exerted by said container when said container is inserted into and / or removed from the receptacle.

[0120] Rotation angle The angle of rotation of at least a section of the other end of the protrusion is measured relative to a plane that defines 0°. This plane is the neutral plane, as shown in Figures 4A and 4B. When no force is applied to the other end, the other end lies in said plane.

[0121] ridge In one preferred embodiment of the present invention, the sidewall of each receptacle has at least one section with a curved surface, and the at least one section forms at least one ridge that extends into the interior of the respective receptacle. This feature is referred to herein as "sidewall comprising a ridge."

[0122] The protuberance preferably comprises a polymer. Examples of preferred polymers include polypropylene, polyoxymethylene, polyethylene, polyethylene terephthalate, polystyrene, cycloolefin copolymer (COC), and cycloolefin polymer (COP). Here, polypropylene is particularly preferred for the protuberance. The protuberance is preferably integrally formed with the sidewall of the receptacle. In a preferred embodiment of the present invention, the protuberance extends in a direction substantially perpendicular to the sidewall of the receptacle.

[0123] The feature "the side wall of each receptacle has at least one section with a curved surface, and at least one section forms at least one ridge" should be understood to mean that the ridge has a curved surface. The curvature of the surface of the section of the side wall that forms the ridge is preferably perpendicular to the length of each receptacle.

[0124] A ridge preferably extends along at least 75%, more preferably at least 85%, and even more preferably at least 95% of the length of the receptacle in which said ridge is located.

[0125] If the receptacle includes raised portions, it is preferred that said receptacle includes an even number of raised portions.

[0126] container The container referred to herein comprises a container wall that at least partially surrounds the internal volume of the container. The container referred to herein is designed to contain a composition such that the inside of the container wall (i.e., the side of the container wall facing the internal volume) and / or a coating layer (e.g., a lubricating layer) on the inside of the container wall can directly contact the composition. Preferred containers are suitable for use in containing pharmaceutical and / or cosmetic compositions.

[0127] The first end of the container preferably includes a first orifice that allows the composition to be loaded into the interior volume of the container. Preferably, the first orifice also allows the composition to be expelled from the interior volume.

[0128] The internal volume of a container refers to the total volume of the interior of the container. This volume can be determined by filling the internal volume with water up to the brim of the container and measuring the volume of the amount of water that the internal volume can take up to the brim. Therefore, the internal volume used herein is not a nominal volume as is often referred to in the pharmaceutical technical field. This nominal volume may, for example, be smaller than the internal volume.

[0129] The container may have any size or shape that one skilled in the art would deem appropriate in the context of the present invention. Preferred containers have at least one section that is cylindrical. Preferred containers are elongated.

[0130] A preferred container, more preferably a container wall, comprises, or more preferably consists of, at least one glass, at least one polymer, or a combination thereof. The glass may be any type of glass and may have any composition that a person skilled in the art would deem appropriate in the context of the present invention. Preferably, the glass is suitable for pharmaceutical compositions. A preferred glass is Type I according to the glass type definitions in Section 3.2.1 of the European Pharmacopoeia, 7th Edition, 2011. Examples of preferred glasses include borosilicate glass, quartz glass, and combinations thereof. Particularly preferred glasses are borosilicate glass. Examples of preferred polymers include polypropylene, polyoxymethylene, polyethylene, cycloolefin copolymers (COC), and cycloolefin polymers (COP). Here, cycloolefin copolymers (COC) and cycloolefin polymers (COP) are particularly preferred.

[0131] Examples of preferred containers include cartridges, vials, ampoules, carpules, and syringes. Preferably, all of the containers in the plurality of containers are the same type, preferably selected from the above-mentioned preferred container examples. Preferred syringes are made of glass or polymer.

[0132] Additionally or alternatively, preferred syringes have an internal volume in the range of 0.5 to 100 ml, preferably 0.5 to 80 ml, and more preferably 0.5 to 60 ml. Additionally or alternatively, preferred syringes include a body portion, also referred to as a barrel, which is preferably cylindrical. Preferred barrels of syringes have a diameter in the range of 5 to 50 mm, more preferably 6 to 45 mm, even more preferably 8 to 40 mm, and most preferably 9 to 35 mm. It is particularly preferred that the barrel be made from glass or polymer.

[0133] A preferred container, more preferably the container wall, more preferably the surface of the container wall facing the internal volume of the container, comprises at least one coating layer. Here, the coating layer is preferably understood as a layer applied by any method known to those skilled in the art working in the pharmaceutical industry. These methods include applying the coating layer by spraying or rubbing the coating layer onto the container wall facing the internal volume of the container. A preferred coating layer is a lubricating layer. A preferred lubricating layer comprises silicon. A preferred lubricating layer reduces friction when a component of the container is moved within the internal volume of the container. Here, an example of a component is a syringe plunger, and the syringe is an example of a container. For example, the lubricating layer reduces the force required to move the plunger inside the syringe barrel.

[0134] Pharmaceutical and cosmetic compositions In the context of the present invention, any pharmaceutical composition and any cosmetic composition deemed appropriate by a person skilled in the art are considered. A pharmaceutical composition is a composition containing at least one pharmaceutically active ingredient. A preferred pharmaceutically active ingredient is a vaccine. A cosmetic composition is a composition containing at least one cosmetically active ingredient. A preferred cosmetically active ingredient is hyaluronic acid or botulinum toxin. A pharmaceutical composition and / or cosmetic composition may be fluid or solid, or both, with fluid compositions being particularly preferred herein. Preferred solid compositions are in granular form, such as powders, multiple tablets, or multiple capsules. Further preferred pharmaceutical and / or cosmetic compositions are parenteral substances, i.e., compositions intended to be administered via a parenteral route, which may be any route other than enteral. Parenteral administration can be by injection, for example, using a needle (usually a hypodermic needle) and syringe, or by insertion of an indwelling catheter.

[0135] The invention will now be illustrated by way of non-limiting examples and exemplary embodiments.

[0136] The figures serve to illustrate the invention and should not be considered as limiting the invention. Further, the figures are not drawn to scale. [Brief explanation of the drawings]

[0137] [Figure 1] 1 is a schematic diagram showing a cross section of a structure according to the present invention; [Figure 2A] 10 is a schematic diagram showing another end of the protrusion that is movable relative to the receptacle side wall. FIG. [Figure 2B] 10 is a schematic diagram showing another end of the protrusion that is movable relative to the receptacle side wall. FIG. [Figure 3A] FIG. 10 is a schematic diagram showing how the dimensions of the receptacle and protrusion are measured. [Figure 3B] FIG. 10 is a schematic diagram showing how the dimensions of the receptacle and protrusion are measured. [Figure 3C] FIG. 10 is a schematic diagram showing how the dimensions of the receptacle and protrusion are measured. [Figure 3D] FIG. 10 is a schematic diagram showing how the dimensions of the receptacle and protrusion are measured. [Figure 4A] FIG. 1 is a schematic diagram showing how the rotation angle of a protrusion is measured. [Figure 4B] FIG. 1 is a schematic diagram showing how the rotation angle of a protrusion is measured. [Figure 5A] 1A and 1B are views of a first embodiment of a protrusion according to the invention; [Figure 5B] 1A and 1B are views of a first embodiment of a protrusion according to the invention; [Figure 5C] 1A and 1B are views of a first embodiment of a protrusion according to the invention; [Figure 6A] 3A and 3B are views of a second embodiment of a protrusion according to the present invention; [Figure 6B] 3A and 3B are views of a second embodiment of a protrusion according to the present invention; [Figure 6C] 3A and 3B are views of a second embodiment of a protrusion according to the present invention; [Figure 7A] 1A and 1B show a first set and another set of protrusions according to the present invention. [Figure 7B] 1A and 1B show a first set and another set of protrusions according to the present invention. [Figure 7C] 1A and 1B show a first set and another set of protrusions according to the present invention. [Figure 8] 8 is a flow chart illustrating steps of a method 800 for filling multiple containers. [Figure 9] 1 is a flow chart illustrating steps of a method for transporting a plurality of containers. [Figure 10] FIG. 1 is a schematic diagram of the test method used to measure the force required to remove a container from a receptacle. [Figure 11] 10A-10C show examples of first ends of protrusions formed as hinges.

[0138] Text description of the illustration image022.gif. FIG. 1 is a schematic diagram showing a cross section of a structure 100 according to the present invention. Structure 100 is viewed from the side. The structure includes a plurality of receptacles, such as receptacle 101a. As shown for receptacle 101a, the receptacle has a sidewall 102a that defines an interior 103 of said receptacle 101a. Protrusions 104a and 104b are disposed on sidewall 102a and extend into interior 103 of receptacle 101a. As shown for protrusion 104a, the protrusion has a first end 105 and another end 106 (located opposite first end 105), where first end 105 is attached to sidewall 102a. As also shown for receptacle 101a, the receptacle has a first end 107 and another end 108. First end 107 is located at or near first surface 109 of structure 100. First surface 109 may also be referred to as the top or upper surface of structure 100. FIG. 1 further shows that container 110 is received within receptacle 101b. Container 110 has first end 111, another end 112, and body 131. From FIG. 1, it can be seen that body 131 (an example of a first section) of container 110 has a smaller diameter than the diameter of another end 112 (an example of another section). As a result, gap 113 is formed between container 110 and sidewall 102b of receptacle 101b. Protrusions 104c and 104d contact container 110, thereby at least partially preventing container 110 from tilting within receptacle 101b. Preferably, contact between protrusions 104c and 104d and container 110 does not cause container 110 to be gripped by said protrusions. Container 110 in Figure 1 is a syringe having a flange (first end 111), a barrel (body 131), and a cap (another end 112). The container is inserted into structure 100 at the first end of the receptacle.

[0139] 2A and 2B are schematic diagrams illustrating another end of a protrusion that can move relative to a receptacle sidewall. In particular, FIGS. 2A and 2B illustrate a receptacle 101 constructed in accordance with the present invention. FIG. 2A illustrates a force 132 being applied to protrusion 104a. This force 132 results, for example, from inserting a container (not shown) into the receptacle and contacting another end of the container with protrusion 104a. As a result, another end 106 of protrusion 104a moves relative to sidewall 102 of receptacle 101 (e.g., protrusion 104a is deformed). More specifically, protrusion 104a rotates about first end 105 of protrusion 104a (e.g., first end 105 is formed as a hinge). For comparison, protrusion 104b is shown without any force applied to it. It can be seen that protrusion 104b is disposed perpendicular to sidewall 102. This position, when no force is applied, is also referred to as the neutral position of the protrusion. If another end of the protrusion moves relative to the sidewall during insertion and / or removal of a container, the protrusion preferably at least partially returns to the neutral position (i.e., the protrusion is resiliently deformable) when the container is placed in and / or removed from the receptacle. Note that when a container is inserted into a receptacle, it is very likely that a force will be applied to all of the protrusions in the receptacle. However, for purposes of illustration, protrusion 104b is shown without any force applied.

[0140] 2B is the same as FIG. 2A, except for the following: As can be seen in FIG. 2B, protrusion 104a bends along its length (e.g., protrusion 104a is deformable) while force 132 is applied. In FIG. 2B, first end 105 of protrusion 104a is not formed as a hinge. However, it should be noted that even if first end 105 of protrusion 104a is formed as a hinge, the protrusion can still deform, as shown in FIG. 2B.

[0141] 3A-3D are schematic diagrams showing how the dimensions of the receptacle and protrusion are measured. For illustrative purposes, the receptacle is only partially shown. FIG. 3A shows that the length 114 of the receptacle 101 is measured between the first end 107 and the other end 108 of the receptacle. The length 114 is also measured parallel to the other direction 119. This also applies when the receptacle has a variable diameter (e.g., the receptacle has a conical shape). Here, the length is measured along an axis passing through the center of the receptacle, the axis being parallel to the other direction 119. The distance 115 that the protrusion extends into the interior 103 of the receptacle 101 is measured between the first end 105 and the other end 106 of the protrusion 104. Further, distance 115 is measured parallel to first direction 118, which is perpendicular to another direction 119. If the receptacle has a varying diameter (e.g., the receptacle has a conical shape), distance 115 is nevertheless measured parallel to first direction 118 (i.e., the distance is not measured along an axis perpendicular to sidewall 102, since the sidewall is not parallel to another direction 119). Thickness 116 of protrusion 104 is measured as shown in FIG. 3A. FIG. 3B is a top view of receptacle 101. Width 117 of protrusion 104 is measured as shown in FIG. 3B. Note that thickness 116 and width 117 are not necessarily measured parallel to first direction 118, another direction 119, or a direction perpendicular to both first direction 118 and another direction 119.

[0142] Figure 3C shows how distance 128 of protrusion 104 from first end 107 of the receptacle is measured. Figure 3C also shows how distance 129 of protrusion 104 from another end 108 of the receptacle is measured. Both of these distances are measured parallel to another direction 119, even if the receptacles have varying diameters (e.g., the receptacles have a conical shape). Figure 3D shows how the distance between a protrusion of first set of protrusions 126 and a protrusion of another set of protrusions 127 is measured. The distance is measured parallel to another direction 119, even if the receptacles have varying diameters (e.g., the receptacles have a conical shape).

[0143] 4A and 4B are schematic diagrams showing how the rotation angle of a protrusion is measured. For illustrative purposes, the receptacle is only partially shown. FIG. 4A corresponds to the receptacle shown in FIG. 2A. When a protrusion (such as protrusion 104b) is in a neutral position, the other end 106 of protrusion 104b lies within a neutral plane 120. When a sufficient force is applied, the other end 106 of protrusion 104a moves outward from the neutral plane 120. A plane 121 tangent to the other end 106 fits into protrusion 104a. Angle 122a between neutral plane 120 and tangent plane 121 is defined as the rotation angle of the other end 106. FIG. 4B corresponds to the receptacle shown in FIG. 2B. The rotation angle of the other end 106 in FIG. 4B is determined in the same manner as described for FIG. 4A. It should be noted that the angle of rotation need not be only about a direction perpendicular to the first direction 118 and about another direction 119. If the protrusion is rotated, for example, about another direction 119, the neutral plane of Figures 4A and 4B should be rotated about the first direction 118 accordingly.

[0144] 5A-5C are diagrams of a first embodiment of a protrusion according to the present invention. FIG. 5A is an isometric view of a cross section of a structure according to the present invention. As can be seen, protrusion 104 is arranged as a flap at another end 108 of receptacle 101. Receptacle 101 also has ridges 125 extending along the length of receptacle 101. Protrusion 104 is arranged between ridges 125. FIG. 5B is a top view of the structure of FIG. 5A, where it can be seen that protrusion 104 is arranged around the circumference of receptacle 101. FIG. 5C is a view from below of the structure of FIG. 5A. Note that when container 110 is received in the receptacle, protrusion 104 is in a neutral position.

[0145] 6A-6C are diagrams of a second embodiment of a protrusion according to the present invention. FIG. 6A is an isometric view of a cross section of a structure according to the present invention. As can be seen, protrusion 104 is positioned as a pin at a distance from another end 108 of receptacle 101. FIG. 6B is a top view of the structure of FIG. 6A, where it can be seen that protrusion 104 is positioned around the circumference of receptacle 101. FIG. 6C is a view from below of the structure of FIG. 6A. Note that when container 110 is received in the receptacle, protrusion 104 is in a neutral position.

[0146] 7A-7C illustrate first and second sets of protrusions according to the present invention. FIG. 7A is an isometric view of a cross section of a structure according to the present invention. Receptacle 101 has a first set of protrusions 126 (protrusions 126a and 126b are shown) that are positioned closer to second end 108 of receptacle 101 than first end 107. Receptacle 101 also has a second set of protrusions 127 that are positioned closer to first end 107 of receptacle 101 than second end 108. FIG. 7B is a top view of the structure of FIG. 7A, where it can be seen that first set 126 and second set 127 of protrusions are alternately positioned around the circumference of receptacle 101. FIG. 7C is a view from below of the structure of FIG. 7A.

[0147] FIG. 8 is a flow chart illustrating steps of a method 800 for filling multiple containers with a composition. In step 801, a structure according to the present invention (e.g., any of the structures shown in FIGS. 5-7) is provided. In step 802, multiple containers are inserted into the structure. This leads to deformation of the protrusions (movement of their respective ends) partially along the insertion direction of the containers. This allows for improved centering of the containers within the receptacle. Once the containers are received in the receptacle, the respective ends of the protrusions return to the positions they had before the containers were inserted (neutral positions). Preferably, the protrusions contact the containers such that the containers are not gripped by the protrusions. In step 803, the containers are partially filled with the pharmaceutical composition. In step 804, the partially filled containers are removed from the structure. During removal of the containers, the protrusions deform (movement of their respective ends) at least partially along the removal direction. Once the containers are removed, the respective ends of the protrusions return to the positions they had before the containers were inserted (neutral positions).

[0148] FIG. 9 is a flow chart showing steps of a method 900 for transporting a plurality of containers. In step 901, a structure according to the present invention (e.g., any of the structures shown in FIGS. 5-7) is provided. In step 902, a plurality of containers are inserted into the structure. Step 902 is as described for step 802 of FIG. 8. In step 903, the structure and the containers received therein are transported from a first location to another location. The first location can be a sterilization station for sterilizing the structure and the containers received therein. The other location can be a filling station for partially filling the containers with a composition.

[0149] FIG. 10 is a schematic diagram of a test method 1000 used to measure the force required to remove a container from a receptacle. A structure 133 rests on a support 136 (such as a table). The support 136 has at least one opening 137 that aligns with an opening in the receptacle 101 of the structure 133. A piston 134 attached to a force sensor 135 is inserted into the receptacle 101 and contacts the protrusion. The other end of the protrusion should not move as a result of the contact. Furthermore, the piston 134 is positioned so that the overlap distance 138 between the edge of the piston and the protrusion 104 is 0.5 mm. The force exerted by the piston 134 on the protrusion 104 is then increased until the other end of the protrusion 104 moves from its neutral position. The force required to cause the movement is defined as the force required to remove the container from the receptacle.

[0150] 1 and 5A-5C show the protrusions disposed in a plane perpendicular to another direction (e.g., perpendicular to the length of the receptacle), this is not a requirement. For example, the protrusions may also be disposed in a plane that is angled with respect to at least one or all of the first direction, the other direction, and an additional direction that is disposed perpendicular to both the first direction and the other direction.

[0151] FIG. 11 is an example of a first end 105 of a protrusion 104 formed as a hinge. The protrusion 104 has a portion 139 having a reduced thickness compared to the thickness of the remainder of the protrusion 104. When the first end of the protrusion is arranged as a hinge as shown in FIG. 11, the thickness of the first end 105 should not be measured at the location of portion 139, but rather at a location 140 directly adjacent to said portion 139. In other words, when determining the thickness variation between the first end and another end of the protrusion, the thickness measured at location 140 and the thickness measured at the other end 106 are taken into account.

[0152] Test Method The following test methods were utilized within the context of the present invention: Unless otherwise stated, measurements were made at an ambient temperature of 23° C., an ambient pressure of 100 kPa (0.986 atm) and a relative air humidity of 50%.

[0153] size The length of the receptacle is measured using calipers. The distance the protrusion extends into the interior volume, as well as the thickness and width of the protrusion, are also measured using calipers.

[0154] Weight of the structure The weight W of the structure is calculated using the following formula: W=M S *G where M S is the mass of the structure measured in g, and G = 981 cm / s 2 is the gravitational acceleration constant.

[0155] Force required to remove the container The force required to remove the container from the receptacle is explained in FIG. 10 and the accompanying drawing legend.

[0156] Elastic modulus The modulus of elasticity is determined according to standard ISO 527.

[0157] Receptacle Diameter The diameter of a receptacle is measured between two points on the sidewall of the receptacle that are closest to each other, with the line connecting the two points passing through the center of the receptacle. If the receptacle includes ridges (or other structures) that extend into the interior of the receptacle (see, for example, FIG. 5A), the two closest points may be located on the two ridges (or other structures).

[0158] angle The angles are measured using a protractor.

[0159] Example The present invention is further illustrated by the following examples, which are not intended to limit the scope of the present invention.

[0160] Example 1 Example 1 is repeated with two different structures. In Example 1.1 (Example of the invention), the structure shown in Figure 5 is provided. Each receptacle has six protrusions arranged at different ends of the receptacle. Each protrusion extends a distance of 3.5 mm into the interior of the receptacle. The maximum thickness of the protrusions is 1.5 mm. The first ends of the protrusions are arranged as hinges.

[0161] In Example 1.2 (Comparative), a structure similar to that of Example 1.1 is provided, except that the structure does not have protrusions.

[0162] For both Example 1.1 and Example 1.2, the following steps are performed: A syringe (container) is inserted into the structure at a first station. The structure and syringe are then transported to a filling station. At the filling station, the syringe is partially filled with a pharmaceutical composition. The structure and syringe are then transported to another station where the syringe is removed.

[0163] Table 1 shows the comparison of technical effects between Example 1.1 and Example 1.2. [Table 1]

[0164] The technical effects of Table 1 are as follows: Packing density. The density of syringes within a structure that can still be obtained while minimizing contact between said syringes. "+" indicates a greater packing density, and "-" indicates a lower packing density. Increasing the packing density is desirable. - Reduced container tilt. How well the syringe is kept upright within the structure during syringe insertion, transport, and processing (e.g., filling). A "+" indicates a lesser syringe tilt, and a "-" indicates a more tilted syringe. It is desirable to have a lesser tilt. - Reduced damage to the container during insertion. Damage caused to the syringe during insertion of the syringe into the structure. "+" indicates less damage and "-" indicates more damage. Reduced damage is desirable. - Reduced damage to the container during removal. Damage caused to the syringe during removal of the syringe from the structure. "+" indicates less damage and "-" indicates more damage. Reduced damage is desirable. - Improved ease of container removal. How easily the syringe can be removed from the structure (e.g., amount of force required). A "+" indicates that the syringe is easier to remove, and a "-" indicates that the syringe is more difficult to remove. Increasing the ease of removal (e.g., reducing the amount of force required to remove the syringe) is desirable. -Reduced damage to containers during transport. Damage caused to syringes during transport of syringes within the structure. "+" indicates less damage, "-" indicates more damage. Reduced damage is desirable. - Reduced damage to the filling needle and container. When a syringe is partially filled with a composition, contact between the container and the needle often leads to damage to the filling needle and / or syringe. "+" indicates less damage and "-" indicates more damage. Reducing damage is desirable. - Reduction of filling station downtime. For example, downtime as a result of problems with the equipment used to fill the syringes. "+" indicates smaller downtime and "-" indicates larger downtime. Reducing downtime is desirable. - Reduction of particle formation on the container. When a syringe is placed in a structure (such as during transport of the syringe), contact between the receptacle sidewall and the syringe very often leads to the formation of particles on the surface of the syringe. A "+" indicates fewer particles are formed, and a "-" indicates more particles are formed. It is desirable to reduce the number of particles formed.

[0165] The structures of Examples 1.1 and 1.2 can also be used, for example, to hold carpoule while filling the carpoule with a composition. Compared to the structure of Example 1.2, the structure of Example 1.1 allows for a significant reduction in the variation in the volume of the composition within the carpoule. It is desirable that the volume of the composition does not vary between carpoules.

[0166] Example 2 Example 2 is repeated using the structure of Example 1.1, with the following differences: The force required to remove / insert the syringe from / into the receptacle varies as shown in Table 2. The weight of the structure is 0.8 N. [Table 2]

[0167] The technical effects of Table 2 are as described in Table 1. In addition, Table 2 has the following additional effects: - Reduced damage to the structure during insertion. Damage to the structure during insertion of the syringe into the structure (insertion very often leads to deformation of the structure). "+" indicates less damage to the structure, "-" indicates more damage to the structure. It is desirable to reduce damage to the structure during insertion. - Reducing process downtime. During the insertion and / or removal of syringes from the structure, issues may arise with the equipment used to insert and / or remove syringes from the structure. A "+" indicates a smaller downtime and a "-" indicates a larger downtime. Reducing downtime is desirable. [Explanation of symbols]

[0168] 100 Structure 101 Receptacle 102 Side wall 103 Receptacle interior 104 Protrusion 105 first end of protrusion 106 Another end of the protrusion 107 First end of receptacle 108 Another end of the receptacle 109 First Surface of Structure 110 Container 111 first end of container 112 Another end of the container 113 Gap between container and side wall 114 Receptacle Length 115 Distance that the projection extends into the interior of the receptacle 116 Thickness of protrusion 117 Protrusion width 118 First Direction 119 Another Direction 120 Midplane 121 Tangent plane 122 rotation angle 123 Rotation axis 125 Ridge 126 First set of prongs 127 Another set of prongs 128 Distance from the first end of the receptacle 129 Distance from another end of the receptacle 130 Distance between sets of protrusions 131 Container body 132 Force applied to protrusion 133 Structure 134 Piston 135 Force Sensor 136 Support 137 Opening in support 138 Overlap Distance 139 Protruding Part 140 Location where thickness is measured

Claims

1. A structure comprising a plurality of receptacles, a. the receptacle is adapted and arranged to receive a plurality of containers; b. each receptacle of the plurality of receptacles includes a sidewall defining an interior of the respective receptacle; i. at least one protrusion disposed on said sidewall and extending into said interior of said respective receptacle; ii. the at least one protrusion has a first end and another end; A. the first end is disposed opposite the other end; B. the first end is attached to the side wall; at least one section of the other end of the at least one protrusion is adapted and arranged to be movable relative to the sidewall on which the protrusion is disposed; structure.

2. 2. A structure according to claim 1, wherein at least a segment of said at least one projection, preferably said at least one section, is adapted and arranged to be deformable, preferably elastically deformable.

3. 3. The structure of claim 1 or 2, wherein said at least one section of said other end is adapted and arranged to rotate through an angle in the range of -90° to 90°.

4. 4. The structure of claim 1, wherein the force required to remove a container from each receptacle is less than or equal to the weight of the structure.

5. 5. A structure according to any one of claims 1 to 4, wherein the force required to remove a container from its respective receptacle is 1N or less.

6. 6. The structure of any one of claims 1 to 5, wherein the at least one protrusion has a modulus of elasticity in the range of 0.80 to 3.50 GPa.

7. The at least one protrusion is spaced from the interior volume of the respective receptacle by a distance yD. ＭＩＮ where D ＭＩＮ 7. A structure according to any one of claims 1 to 6, wherein y is the minimum diameter of said respective receptacle, and y is in the range of 0.015 to 0.

3.

8. 8. A structure according to any one of claims 1 to 7, wherein the maximum thickness of said at least one protrusion is in the range of 0.05 mm to 4 mm.

9. 9. The structure of claim 1, wherein each receptacle comprises at least two projections.

10. 10. The structure of any one of claims 1 to 9, further comprising a plurality of containers containing less than 0.1 ml of the composition.

11. 11. The structure of any one of claims 1 to 10, further comprising a plurality of containers that are at least 20% filled with the composition, said percentage being relative to the internal volume of the containers.

12. 1. A method for at least partially filling a plurality of containers with a composition, comprising: Providing a structure according to any one of claims 1 to 11; b. inserting a plurality of containers into the plurality of receptacles of the structure, wherein the at least one protrusion preferably deforms during the insertion; c. at least partially filling said container with said composition; A method comprising:

13. A plurality of containers at least partially filled with a composition obtained according to claim 12.

14. 1. A method for transporting a plurality of containers, comprising: Providing a structure according to any one of claims 1 to 11; b. inserting a plurality of containers into said structure; c. transporting the structure and the plurality of containers from a first location to another location; A method comprising:

15. a. reducing contact between a plurality of receptacles and a plurality of containers received within said receptacles; b. Reducing contact between adjacent vessels housed within the structure; c. reducing the number of particles on the surface of the container received within the structure; d. reducing damage to the container when received within the structure; 12. Use of a structure according to any one of claims 1 to 11 to perform at least one or all of the following:

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