Optical fiber transmission device

Abstract

To provide an optical fiber transmission device capable of irradiating a test object target with irradiation light having more than two types of wavelengths, thereby enabling enhanced inspection accuracy.SOLUTION: An optical fiber transmission device includes an irradiation system that transmits light from a light source 2 through an irradiation fiber 14 to irradiate a test object X, and a light reception system that receives light from the test object X through a light reception fiber 24. The irradiation system has a first rotating part 10, first drive means 12 for driving the first rotating part 10 to rotate about a first rotational axis, a plurality of irradiation fibers 14, and a connecting fiber 16. The rotation of the first rotating part 10 causes transmitted light of a wavelength having passed through a light-modulating filter part 4 to be incident onto one end of the connecting fiber 16, and with the other end of the connecting fiber 16 being tracing a first circular path, the light is transmitted through the irradiation fiber 14.SELECTED DRAWING: Figure 1

Description

[Technical Field]

[0001] The present invention relates to an optical fiber transmission device, and more particularly to an optical fiber transmission device including an illumination system that transmits light from a light source through an illumination fiber and illuminates the object under test, and a light receiving system that receives light from the object under test through a light receiving fiber. [Background technology]

[0002] In recent years, it has become common to obtain various information about reactions in solutions containing biochemical substances such as DNA, proteins, fats, and sugar chains that are labeled with multiple types of fluorescent substances by measuring the fluorescent substances.

[0003] In the first example, various DNA fragments with unknown base sequences are labeled with multiple types of fluorescence and the binding state between them and DNA fragments with known base sequences immobilized on a DNA chip or the like, which bind complementarily to them, is measured. The second example is application to real-time PCR, in which nucleic acid (DNA) amplified by PCR is monitored in real time using a fluorescent substance.

[0004] In these instances, rapid optical measurements are required along with accurate quantitative measurements, for which various devices have been developed.

[0005] However, when performing measurements, for example, in real-time PCR, on multiple samples or target substances, it is necessary to label them with fluorescent substances having various wavelengths. Therefore, in a configuration using multiple photomultiplier tubes corresponding to each wavelength, for example, the number of excitation light sources and photomultiplier tubes increases, and a complex optical system is required to branch the fluorescence emitted from the reaction vessel. In addition, the device structure becomes more complex and the device size increases, which poses the risk of increasing manufacturing costs.

[0006] Therefore, the applicant has proposed a fiber optic device for rapid optical measurements. [Prior art documents] [Patent documents]

[0007] [Patent Document 1] Patent No. 5608652 Summary of the Invention [Problem to be solved by the invention]

[0008] In the illumination system of Patent Document 1, light from two light sources is passed through two optical filters, and one of two wavelengths of light is selected by rotating a light-guiding rotating plate equipped with a mirror, and the light is then irradiated onto the target object.

[0009] This means that there are only two types of wavelengths of irradiated light, which does not fully meet the demand for improving the accuracy of PCR testing, for example, by irradiating the target of the test object with light of more than two wavelengths.

[0010] Therefore, the main object of the present invention is to provide an optical fiber transmission device that can irradiate a target on an inspection object with irradiation light of more than two wavelength types, thereby improving the accuracy of the inspection. [Means for solving the problem]

[0011] The means for solving the above problems are as follows. An optical fiber transmission device including an illumination system that transmits light from a light source through an illumination fiber and illuminates the light onto an object to be inspected, and a light receiving system that receives light from the object to be inspected through a light receiving fiber, the illumination system includes the light source, a plurality of light control filter units, a first rotating unit, a first driving means that rotates the first rotating unit around a first rotation axis, a plurality of the illumination fibers, and a connecting fiber; a plurality of the light control filter units that convert the light from the light source into transmitted light of mutually different wavelengths are arranged at positions corresponding to a first circular locus around a first rotation axis of the first rotating unit; one end of the connecting fiber is on the first circular locus, and the other end of the connecting fiber faces the entrance ends of the plurality of illumination fibers; One end of the connecting fiber traces the first circular locus by rotation of the first rotating unit, and transmitted light of a wavelength that has passed through the light control filter unit is incident on one end of the connecting fiber and is transmitted from the other end of the connecting fiber through the illumination fiber. An optical fiber transmission device characterized by: [Effects of the Invention]

[0012] In the present invention, the first rotating portion is driven to rotate around the first rotation axis. A plurality of the light modulating filter units are arranged at positions corresponding to a first circular locus around a first rotation axis. The entrance ends of the plurality of illumination fibers lie on the first circular locus. As a result, the incident end of the illumination fiber moves along the first circular locus due to the rotation of the first rotating unit, and because the light control filter unit is provided at a position corresponding to the first circular locus, when the position of the incident end and the position of the light control filter unit match, the incident light that has passed through the light control filter unit is transmitted from the incident end of the illumination fiber to the illumination fiber and into the illumination fiber. Because the structure allows transmission to the illumination fiber sequentially due to the rotation of the first rotating unit, high-speed wavelength switching and transmission of illumination light are possible. If the number of light control filter sections is three or more, incident light of three or more wavelengths can be irradiated onto the target object from the illumination fiber.

[0013] Therefore, the target on the inspection object can be irradiated with irradiation light of three or more wavelengths, rather than just two, and the accuracy of the inspection can be improved. Furthermore, by rotating the first rotating part around the first rotation axis, it is possible to select and switch between three or more types of wavelengths of irradiation light, and the rotation of the first rotating part can be achieved by a simple mechanical means, for example, driven by a motor, and high-speed rotation is also possible, so that three or more types of wavelengths of irradiation light can be selected at high speed. [Brief explanation of the drawings]

[0014] [Figure 1] FIG. 1 is a schematic explanatory diagram of an entire optical fiber transmission device. [Figure 2] FIG. 2 is a perspective view of the main parts of an illumination system and a light receiving system. [Figure 3] FIG. 2 is a perspective view of the main parts of an illumination system and a light receiving system. [Figure 4] FIG. 2 is a perspective view of the main parts of the illumination system and the light receiving system from a different viewpoint. [Figure 5] FIG. 2 is a perspective view of a first rotating part. [Figure 6] FIG. 1 is a perspective view of a first example of an inspection object. [Figure 7] FIG. 2 is a perspective view of a first linking means. [Figure 8] FIG. [Figure 9] FIG. 1 is a perspective view of a Geneva gear. [Figure 10] FIG. [Figure 11] FIG. 10 is a perspective view of a second example of the test object. [Figure 12] FIG. 10 is a plan view of a second example of the test object. [Figure 13] FIG. 10 is a front view of a second example of the test object. [Figure 14] FIG. 10 is a side view of a second example of the test object. [Figure 15] FIG. 10 is a perspective view of a second example of the test object. [Figure 16] FIG. 10 is a perspective view of the second example of the test object, showing a state in which the fiber fixing plate has been moved. [Figure 17] FIG. 10 is an explanatory diagram showing the relationship between the light control filter unit and the incident end of the illumination fiber, in which the light source and the light control filter unit arranged in the circumferential direction are shown expanded in the planar direction. [Figure 18] FIG. 10 is a schematic perspective view of a second linking means. [Figure 19] FIG. 10 is a schematic perspective view of the second linking means from a different perspective. DETAILED DESCRIPTION OF THE INVENTION

[0015] Next, an embodiment of the present invention will be described with reference to the drawings. Note that the embodiment is merely an example of the present invention, and the scope of the present invention is not limited to the scope of the embodiment.

[0016] (Embodiment of Irradiation System) As shown in Figures 1 and 2, an optical fiber transmission device is provided, which includes an illumination system that transmits light from a light source 2 through an illumination fiber 14 and illuminates an object X1 to be inspected, and a light receiving system that receives light from the object X1 to be inspected through a light receiving fiber 24.

[0017] The illumination system includes the light source 2, a first rotating unit 10, a plurality of dimming filter units 4, a first driving means 12 that rotates the first rotating unit 10 around a first rotation axis, a plurality of the illumination fibers 14, and a first connecting fiber 16. A plurality of the dimming filter units 4 are arranged at positions corresponding to the first circular locus 10L around the first rotation axis 11 of the first rotating unit 10, and convert the light from the light source 2 into transmitted light of mutually different wavelengths.

[0018] One end of the connecting fiber 16 is located on the first circular locus 10L, and the other end of the connecting fiber 16 faces the entrance ends of the plurality of illumination fibers 14; One end of the connecting fiber 16 traces the first circular locus 10L as the first rotating unit 10 rotates, and transmitted light of a wavelength that has passed through the dimming filter unit 4 is incident on one end of the connecting fiber 16 and is transmitted from the other end of the connecting fiber 16 through the illumination fiber 14.

[0019] The optical fiber transmission device of the embodiment is disposed at an appropriate position in a housing (not shown) of an inspection device in which the inspection object X1 is provided. The drive system of the optical fiber transmission device is fixed to, for example, a base 30, and the base 30 is fixed to the housing.

[0020] The base 30 includes a substrate 30A, an upper plate 30B, and a support 30C connecting these together. For example, a light source case 32 and a light receiving case 34 are provided on the substrate 30A.

[0021] 17, the light source case 32 is provided with light sources 2, preferably six light sources 2a to 2f in the illustrated embodiment, the number of which corresponds to the number of multiple light control filter units 4 (six light control filter units 4a to 4f in the illustrated embodiment). It is particularly preferable that there are three or more light sources 2 and three or more light control filter units 4.

[0022] In the illustrated embodiment, the first rotating unit 10 is a circular plate, and six dimming filter units 4a to 4f (see Figure 17) are arranged at positions corresponding to a first circular locus 10L (see Figures 1 and 2) around the first rotating axis 11. As shown in FIGS. 3 and 4, the first rotating part 10 is rotated by a transmission belt 12B wound between a driven shaft at the bottom of the first rotating part 10 and the output shaft of a motor 12A.

[0023] The base ends of a plurality of (for example, six) illumination fibers 14 are bundled together to form an incident end 14A (see also FIG. 17). On the other hand, a connecting fiber 16 that rotates around the first rotation shaft 11 is provided on the first rotating part 10 and the first rotation shaft 10A.

[0024] 6, the first connecting fiber 16 passes through the protective tube 16a and the first shaft portion 10A. One end 16b (lower end) of the first connecting fiber 16 passes through the disk portion of the first rotating portion 10 and opens opposite the light control filter portion 4 in the first circular locus 10L on which the light control filter portions 4 are arranged. The other end 16c (upper end) of the first connecting fiber 16 is disposed opposite the incident end 14A of the bundle of multiple illumination fibers 14. The transmitted light of the wavelength that has passed through the dimming filter unit 4 reaches the other end 16c from one end 16b of the first connecting fiber 16, and is transmitted through the illumination fibers 14 from the incident end 14A.

[0025] The other end side (on the side of the test object X1) of each of the illumination fibers 14 is individualized and disposed opposite to the capillary of the cartridge of the test object X1 (see FIG. 7).

[0026] 1, the light receiving system is configured so that light from the capillary of the cartridge of the test object X1 passes through a light receiving fiber 24 and is received by a light receiving processor 50. An example of the light receiving processor 50 is a photomultiplier (photoelectric converter), which converts the optical signal into an electrical signal and reads it as various types of information.

[0027] In the above embodiment, a plurality of light sources 2 are provided at positions corresponding to a plurality of filter sections 4a to 4f, and the numbers of light sources 2a to 2f, light control filter sections 4a to 4f, and illumination fibers 14 are the same and plural. On the other hand, it is also possible to distribute the light from the light source into optical paths greater than the number of light sources and guide it to a plurality of filter sections.

[0028] (Embodiment of the light receiving system) On the other hand, an embodiment of the light receiving system will be described. The light receiving system has a plurality of light receiving fibers 24 arranged corresponding to the first test object X1, a second rotating unit 20, and a second driving means 22 that rotates the second rotating unit 20 around a second rotation axis 21.

[0029] As shown in FIG. 9, the second rotating part 20 has one through-hole 20a formed at a position corresponding to a second circular locus 20L around the second rotating shaft 21 (see also FIG. 1). The plurality of light-receiving fibers 24 can individually direct reflected light into the light-receiving processor 50 .

[0030] However, this increases the number of light receiving processors 50 and becomes a factor that hinders miniaturization of the device, so the second connecting fiber 26 is used to reduce the number of light receiving processors 50, preferably to one.

[0031] The second connecting fiber 26 according to this configuration is adapted to co-rotate with the second rotating unit 20, and the upper end of the second connecting fiber 26 is located on the second circular locus 20L and faces the lower end of one of the six light-receiving fibers 24 shown in Fig. 2 through one through-hole 20a. The lower end side of the second connecting fiber 26 enters the second shaft portion 20A of the second rotating unit 20, and the lower end of the second connecting fiber 26 is open and faces the light-receiving processor 50. The second connecting fiber 26 is provided in a protective tube in the same manner as the first connecting fiber 16, but the reference numeral for the protective tube is omitted.

[0032] If necessary, a light receiving filter for selecting the wavelength of light to be received can be provided between the through hole 20a and the light receiving processor 50.

[0033] In this light receiving system, light from the test object X1 is received by the light receiving processor 50 through the light receiving fiber 24, the through hole 20a and the second connecting fiber 26.

[0034] It is desirable that the number N of illumination fibers 14 and the number N of light receiving fibers 24 are the same, but they do not have to match.

[0035] In the illustrated example, the test object X1 has six measurement sites, and therefore six illumination fibers 14 and six light-receiving fibers 24 are provided. When the test object X2 shown in FIGS. 12 to 16 is the target, the numbers of the irradiating fibers 14 and the receiving fibers can be appropriately allocated.

[0036] As already explained, light from the light source 2 is passed through, for example, six types of filter units 4a to 4f, and the light having six different wavelengths or wavelength bands is sequentially incident on the illumination fiber 14. The illumination light is emitted from the exit end of the illumination fiber 14 to six measurement sites on the test object X1.

[0037] The detection light generated by this irradiation is received sequentially by six light receiving fibers 24 from the six measurement sites of the test object X1, and is incident on the second connecting fiber 26 from the incident end of the light receiving fiber 24, and is received by one light receiving processor 50. The signal photoelectrically converted by the light receiving processor 50 is input to a control and information processing device 100 provided at an appropriate position, where it is analyzed.

[0038] Looking at one of the six measurement sites of the test object X1, it sequentially receives irradiation light of six different wavelengths or wavelength bands (represented by the term "wavelength" unless otherwise specified), sequentially emits six different detection lights, and transmits the information to a control / information processing device (no symbol).

[0039] For example, as shown in FIG. 1, the test object X1 constituting the "BIST" provided by Precision System Science Co., Ltd. has six cartridges, and a holder Xa that commonly holds the output end of the illumination fiber 14 and the input end of the light-receiving fiber 24 moves up and down. During this movement, beads, e.g., 1 mm in diameter, that are enclosed in a line in the capillaries of the cartridges can be sequentially irradiated and detected.

[0040] The beads in "BIST" are immobilized antibodies, antigens, or DNA fragments that bind to the substance to be measured. By arranging and sealing the beads in the capillaries of the cartridge, it is possible to simultaneously measure up to 20 items. In the test object X1, the six cartridges are sequentially irradiated with irradiating light of six different wavelengths, and the next stage of capillaries is similarly sequentially irradiated.

[0041] Various mechanisms can be used to coordinate such sequential illumination and corresponding reception. (First linking means) The first linking means uses a Geneva gear mechanism G. This Geneva gear mechanism G has a pinned disk 52 serving as a driving wheel and a Geneva gear 54 serving as a driven wheel. The Geneva gear 54 constitutes the second rotating part 20. The pin disc 52 has an arcuate portion 52a and a pin 52b. The pin disc 52 is integral with the upper portion of the first shaft portion 10A.

[0042] In the illustrated example, the Geneva gear 54 has six grooves 54a at the boundary of the concave arc portion, the number of which corresponds to the six wavelengths. In this example, for every full rotation of the pinned disc 52, the Geneva gear 54 rotates 1 / 6 of a rotation, and at other times, contact between the arcs of the pinned disc 52 and the Geneva gear 54 prevents the Geneva gear 54 from rotating.

[0043] As a result, while the first rotating part 10 makes one rotation, the second rotating part 20 (the Geneva gear 54) does not rotate. Although the six cartridges are sequentially irradiated with six different wavelengths of irradiation light, as shown in Figures 1, 2, and 3, the reflected light of the six different wavelengths of irradiation light is received from the six cartridges through only one of the six light receiving fibers 24.

[0044] When the first rotating part 10 moves to the second rotation, the pin 52b rotates the Geneva gear 54 to a 2 / 6 rotation position. As a result, the through hole 20a of the second rotating part 20 (Geneva gear 54) moves to a position facing the second light-receiving fiber 24. In this state (for example, when moved to the second stage of holder Xa), irradiation light of six different wavelengths is sequentially irradiated onto the six cartridges, but the irradiation light of six different wavelengths is received from the six cartridges through only the second light receiving fiber 24 out of the six light receiving fibers 24. Similarly, as the holder Xa moves to the third to sixth stages, the cartridges are irradiated with and receive light from each stage.

[0045] To explain this operation in another form, as shown in Figure 1, in a form in which the first rotating part 10 rotates clockwise in a plan view and the second rotating part 20 including the Geneva gear 54 connected via pin 52b rotates counterclockwise, irradiation and reception of light are performed as follows.

[0046] When the first rotating part 10 rotates clockwise in a planar view, the lower end of the connecting fiber 16 passing through the first rotating part 10 moves along the first circular locus 10L, resulting in the optical paths being connected in sequence to the six dimming filter parts 4a to 4f (see Figure 17) provided in the light source case 32. As a result, light from the light sources 2a to 2f is obtained, and light of six different wavelengths is incident on the illumination fiber 14 through the six light control filter units 4a to 4f.

[0047] The detection light (fluorescence) generated by the irradiation of the illumination light incident on each illumination fiber 14 is received by each light receiving fiber 24, passes through the through hole 20a of the second rotating part 20 (Geneva gear 54), reaches the second connecting fiber 26, and is received by the light receiving processor 50.

[0048] 1, light is irradiated through the six dimming filter units 4a to 4f in the order A → B → ··· → F, and until irradiation of these six types of wavelengths is completed (first cycle), the second rotating unit 20 is composed of a Geneva gear 54, and the arc portion 52a of the pinned disk is in sliding contact with the concave arc of the Geneva gear 54, so that the Geneva gear 54 does not rotate and the position on the second circular locus 20L of the lower end of the second connecting fiber 26 is fixed. From the start to the end of this first cycle, the through hole 10a of the first rotating unit 10 is changed in the order A' → B' → ··· → F' relative to the lower end of the second connecting fiber 26. In the next second cycle, the Geneva gear 54 rotates 1 / 6 of a turn counterclockwise, and so from the start to the end of the second cycle, the through hole 10a of the first rotating part 10 changes relative to the lower end of the second connecting fiber 26 in the order B' → C'... → F' → A'. Similar changes will be made for each subsequent cycle. As described above, the first linking means allows one light receiving processor 50 to receive the detection light associated with the irradiation of the irradiation light of six different wavelengths for each cycle.

[0049] (Second linking means) 18 and 19 show the second linking means. In the first linking means described above, the first rotating part 10 and the second rotating part 20 (the Geneva gear 54) mesh together to link their rotations. In contrast, the second linking means has a drive motor 12A and a light-receiving motor 22A, and the first rotating part 10 and the second rotating part 20C are not meshed with each other, and the drive motor 12A rotates the first rotating part 10, and the light-receiving motor 22A rotates the second rotating part 20C.

[0050] A disk-shaped second rotating portion 20C and a second connecting fiber 26 are integrally provided on the output shaft of the light receiving motor 22A, and are adapted to be driven to rotate. The second connecting fiber 26 has an upper end facing one of the light-receiving fibers 24 and a lower end facing the light-receiving processor 50, similar to the configuration of the first linking means.

[0051] In this second linking means, as in the case of using the first linking means, the second rotating part 20C does not rotate due to the light receiving motor 22A until one rotation of the first rotating part 10 is completed, and light can be received in a state in which the position of the first light receiving fiber 24 is fixed (non-rotating), and the upper end of the second connecting fiber 26 faces the first light receiving fiber 24 through a through hole (not shown) in the second rotating part 20C, and the lower end of the second connecting fiber 26 faces the through hole 10a in the first rotating part 10.

[0052] When one rotation of the first rotating part 10 is completed, the second rotating part 20C is rotated, for example, by 60 degrees by the light receiving motor 22A, so that the lower end of the next second light receiving fiber 24 faces the upper end of the second connecting fiber 26 through the through hole of the second rotating part 20C, and light can be received in a state where the lower end of the second connecting fiber 26 faces the through hole 10a of the first rotating part 10. Thereafter, the same operation is repeated. The rotation of the second rotating part 20C relative to the rotation of the first rotating part 10 can be controlled using an appropriate control device (not shown).

[0053] (Other examples of specimens) The object to be inspected in the embodiment is not limited as long as it can detect the properties of a substance or material by illuminating and receiving light. 12 to 16 show examples of the test object X2.

[0054] The inspection object X2 has a base 110, a guide table 111 thereon, and a traveling rail 112. A support bracket 113 is fixed to the base 110, and a driving wheel 114A and a driven wheel 114B are provided at both ends of the support bracket 113, with a transmission belt 114C wound around these, and a connecting bracket 114E and a fiber fixing plate 115 fixed to a part of the transmission belt 114C can be moved back and forth along the traveling rail 112 by the rotation of a drive motor 114D.

[0055] On the other hand, the guide stage 111 is provided with a plurality of plates 116, each having an appropriate number of liquid storage sections 116a containing the sample to be tested, and a fiber fixing plate 115 is movable back and forth across these plates. The liquid storage section 116a stores, for example, a PCR reaction solution containing a fluorescent substance, and may also be provided with a cleaning liquid or the like, if necessary.

[0056] The end of the illumination fiber 14 and the end of the light-receiving fiber 24 are fixed in pairs to the fiber fixing plate 115, and the illumination end and the light-receiving end open below the fixing hole (not shown) in the fiber fixing plate 115, making it possible to irradiate and receive light into the liquid storage section 116a below.

[0057] For such an object to be inspected X2, the rotation of the drive motor 114D causes the rotation of the transmission belt 114C to move the fiber fixing plate 115 back and forth along the traveling rail 112, and in the process, fluorescence measurement can be performed, for example, in a PCR test, by irradiating light from the irradiating fiber 14 and receiving light from the receiving fiber 24.

[0058] The present invention includes the following aspects. [Aspect 1] An optical fiber transmission device including an illumination system that transmits light from a light source through an illumination fiber and illuminates the light onto an object to be inspected, and a light receiving system that receives light from the object to be inspected through a light receiving fiber, the illumination system includes the light source, a plurality of light control filter units, a first rotating unit, a first driving means that rotates the first rotating unit around a first rotation axis, a plurality of the illumination fibers, and a connecting fiber; a plurality of the light control filter units that convert the light from the light source into transmitted light of mutually different wavelengths are arranged at positions corresponding to a first circular locus around a first rotation axis of the first rotating unit; one end of the connecting fiber is on the first circular locus, and the other end of the connecting fiber faces the entrance ends of the plurality of illumination fibers; One end of the connecting fiber traces the first circular locus by rotation of the first rotating unit, and transmitted light of a wavelength that has passed through the light control filter unit is incident on one end of the connecting fiber and is transmitted from the other end of the connecting fiber through the illumination fiber. An optical fiber transmission device characterized by: [Aspect 2] the base ends of the plurality of illumination fibers are bundled together to form the incident end, the first rotating portion is provided with a first connecting fiber that rotates around a first rotation axis; One end of the first connecting fiber is disposed opposite the first circular locus, and the other end of the first connecting fiber is disposed opposite the incident end of a bundle of multiple illumination fibers; The other end side of each of the illumination fibers is individualized and arranged to face the test object, 2. The optical fiber transmission device according to claim 1, wherein the light receiving system is configured to receive light from each of the test objects through the light receiving fiber and into the light receiving processor. [Aspect 3] the one side of the first connecting fiber passes through the first rotating portion, and one end of the first connecting fiber is disposed facing the first circular locus; The optical fiber transmission device of aspect 2, wherein the other side of the first connecting fiber passes through the first shaft portion, and the other end of the first connecting fiber is positioned opposite the incident end of the bundle of multiple illumination fibers. [Aspect 4] An optical fiber transmission device according to any one of aspects 1 to 3, wherein the light sources are provided in multiple positions corresponding to the multiple filter sections, and the number of the light sources, the number of the dimming filter sections, and the number of the irradiation fibers are the same and multiple. [Aspect 5] the light-receiving system includes a plurality of light-receiving fibers provided corresponding to the test object, a second rotating unit, and second driving means for rotationally driving the second rotating unit around a second rotation axis; a through-hole is formed in the second rotating portion at a position corresponding to a second circular locus around the second rotation axis, and each of the emission ends of the plurality of receiving fibers is positioned on the second circular locus; a second connecting fiber is provided facing the through hole and transmitting the received light to the light receiving processor; The light from the test object is received by the light receiving processor through the light receiving fiber, the through hole, and the second connecting fiber. 5. The optical fiber transmission device according to any one of aspects 1 to 4. [Aspect 6] The number N of the illumination fibers and the number N of the receiving fibers are the same. The optical fiber transmission device according to any one of the first to fifth aspects. [Aspect 7] The optical fiber transmission device according to aspect 5 or 6, wherein the second driving means rotates the second rotating part by a rotation angle of 1 / N per rotation of the first rotating part, and the 1 / N rotation of the second rotating part moves the position of the through hole to a position corresponding to the adjacent optical receiving fiber. [Aspect 8] The second driving means includes: a pinned disk that rotates integrally with the first rotating portion around the first rotation axis; a Geneva gear forming the second rotating portion, N radial grooves and arc portions are formed on the Geneva gear, the pins of the pinned disk engage with the grooves, and the outer circumferential surface of the disk faces the arc portions. 8. The optical fiber transmission device according to any one of embodiments 5 to 7. [Aspect 9] 9. The optical fiber transmission device according to aspect 8, wherein the pinned disk is provided so that the first rotating portion and the first rotating shaft are coaxial. [Aspect 10] The second driving means includes: An optical fiber transmission device according to any one of aspects 5 to 9, comprising an independent second rotating unit that is not linked to the rotation of the first rotating unit, and an independent second driving means that drives the independent second rotating unit to rotate around the second rotation axis. [Industrial Applicability]

[0059] The present invention can be applied to techniques for labeling DNA fragments with multiple types of fluorescence, real-time PCR, and the like. [Explanation of symbols]

[0060] 2, 2a to 2f...light source, 4, 4a to 4f...light control filter section, 10...first rotating section, 10...through hole, 10A...first shaft section, 10L...first circular locus, 11...first rotating shaft, 12...first driving means, 14...illumination fiber, 16...first connecting fiber, 20...second rotating section, 20a...through hole, 20A...second shaft section, 20L...second circular locus, 21...second Rotating shaft, 22A...second driving means, 24...light-receiving fiber, 26...second connecting fiber, 30...base, 50...light-receiving processor, 54...Geneva gear, 54a...groove, 112...traveling rail, 114D...driving motor, 115...fiber fixing plate, 116a...liquid storage section, G...Geneva gear mechanism, X1...first inspection body, Xa...holder, X2...second inspection body.

Claims

1. An optical fiber transmission device including an illumination system that transmits light from a light source through an illumination fiber and illuminates the light onto an object to be inspected, and a light receiving system that receives light from the object to be inspected through a light receiving fiber, the illumination system includes the light source, a plurality of light control filter units, a first rotating unit, a first driving means that rotates the first rotating unit around a first rotation axis, a plurality of the illumination fibers, and a connecting fiber; a plurality of the light control filter units that convert the light from the light source into transmitted light of mutually different wavelengths are arranged at positions corresponding to a first circular locus around a first rotation axis of the first rotating unit; one end of the connecting fiber is on the first circular locus, and the other end of the connecting fiber faces the entrance ends of the plurality of illumination fibers; One end of the connecting fiber traces the first circular locus by rotation of the first rotating unit, and transmitted light of a wavelength that has passed through the light control filter unit is incident on one end of the connecting fiber and is transmitted from the other end of the connecting fiber through the illumination fiber. An optical fiber transmission device characterized by:

2. the base ends of the plurality of illumination fibers are bundled together to form the incident end, the first rotating portion is provided with a connecting fiber that rotates around a first rotation axis; one end of the connecting fiber is positioned opposite the first circular locus, and the other end of the connecting fiber is positioned opposite the entrance end of a bundle of multiple illumination fibers; The other end side of each of the illumination fibers is individualized and arranged to face the test object, 2. The optical fiber transmission device according to claim 1, wherein said light receiving system is configured so that light from each of said test objects is received by said light receiving processor through said light receiving fiber.

3. the one side of the connecting fiber passes through the first rotating portion, and one end of the connecting fiber is disposed facing the first circular locus; 3. The optical fiber transmission device according to claim 2, wherein the other end of the connecting fiber passes through the first shaft portion, and the other end of the connecting fiber is positioned opposite the entrance end of the bundle of multiple illumination fibers.

4. 2. The optical fiber transmission device according to claim 1, wherein the light sources are provided in a plurality of positions corresponding to the plurality of filter sections, and the number of the light sources, the number of the light control filter sections, and the number of the irradiation fibers are the same and plural.

5. the light-receiving system includes a plurality of light-receiving fibers provided corresponding to the object to be inspected, a second rotating unit, and second driving means for rotating the second rotating unit around a second rotation axis; a through-hole is formed in the second rotating portion at a position corresponding to a second circular locus around the second rotation axis, and each of the emission ends of the plurality of light receiving fibers is positioned on the second circular locus; a second connecting fiber facing the through hole for transmitting the received light to the light receiving processor; The light from the test object is received by the light receiving processor through the light receiving fiber, the through hole, and the second connecting fiber.

3. The optical fiber transmission device according to claim 1 or 2.

6. The number N of the illumination fibers and the number N of the receiving fibers are the same.

3. The optical fiber transmission device according to claim 1 or 2.

7. 6. The optical fiber transmission device according to claim 5, wherein the second driving means rotates the second rotating part by a rotation angle of 1 / N per rotation of the first rotating part, and the position of the through hole is shifted to a position corresponding to an adjacent optical receiving fiber by the 1 / N rotation of the second rotating part.

8. The second driving means includes: a pinned disk that rotates integrally with the first rotating portion around the first rotation axis; a Geneva gear forming the second rotating portion, N radial grooves and arc portions are formed on the Geneva gear, the pins of the pinned disk engage with the grooves, and the outer circumferential surface of the disk faces the arc portions.

6. The optical fiber transmission device according to claim 5.

9. 9. The optical fiber transmission device according to claim 8, wherein the pinned disk is provided so that the first rotating portion and the first rotating shaft are coaxial.

10. The second driving means includes:

6. The optical fiber transmission device according to claim 5, further comprising: an independent second rotating part that is not linked to the rotation of the first rotating part; and an independent second driving means that drives the independent second rotating part to rotate around the second rotation axis.

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