Transparent liquid cosmetic

Abstract

To provide a liquid cosmetic that stably remains transparent for an extended period over a broad temperature range, even with high incorporation of one or both of palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine or palmitoyl dipeptide-5 diaminobutyric acid hydroxy.SOLUTION: A transparent liquid cosmetic in which precipitation in the liquid is suppressed, the transparent liquid cosmetic containing one or two of palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine and palmitoyl dipeptide-5 diaminobutyric acid hydroxy, and further containing (b) hydroxypropyl methylcellulose stearoxy ether.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to a liquid cosmetic having a transparent appearance. [Background technology]

[0002] Palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine and palmitoyl dipeptide-5 diaminohydroxybutyric acid are synthetic peptides used as cosmetic ingredients with skin-improving effects.

[0003] These peptides have been reported to improve skin and wrinkles, for example, they have been shown to improve skin appearance and slow down the breakdown of basement membrane proteins due to aging (see Patent Document 1).

[0004] Furthermore, these peptides have been shown to exhibit hair growth activity, scalp care effects, and the effect of promoting FGF-7 production in hair papilla cells, and their use as useful ingredients in cosmetics has been proposed (see Patent Documents 2 to 4). [Prior art documents] [Patent documents]

[0005] [Patent Document 1] International Publication No. 2007 / 124770 [Patent Document 2] International Publication No. 2021 / 075219 [Patent Document 3] International Publication No. 2022 / 065415 [Patent Document 4] International Publication No. 2022 / 065417 Summary of the Invention [Problem to be solved by the invention]

[0006] As mentioned above, palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine and palmitoyl dipeptide-5 diaminohydroxybutyric acid have been proposed as useful ingredients in cosmetics, and cosmetics containing these synthetic peptides have been provided.

[0007] Maintaining the transparency of cosmetic products is important for promoting the image of luxury and safety of the cosmetic product, and is an important factor in the development of cosmetic products that appeal to consumers. Preventing the precipitation of ingredients not only leads to the provision of cosmetics that exhibit stable effects due to those ingredients, but is also important for maintaining the product quality of the cosmetic product over the long term.

[0008] However, it has become clear that when liquid cosmetics containing a large amount of the above-mentioned synthetic peptide are prepared, the peptide easily precipitates, making it difficult to maintain the transparent appearance of the cosmetics. As a result, it has become difficult to provide cosmetics containing a high amount of the peptide as a commercial product that stably maintains a transparent appearance over a wide temperature range for a long period of time.

[0009] Therefore, an object of the present inventors is to provide a liquid cosmetic that maintains a stable, transparent appearance over a wide temperature range for a long period of time even when the aforementioned peptide is incorporated at a high content. [Means for solving the problem]

[0010] As a result of extensive research, the present inventors have discovered that by simultaneously blending palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine, palmitoyl dipeptide-5 diaminohydroxybutyric acid, and hydroxypropyl methylcellulose stearoxy ether, it is possible to obtain a liquid cosmetic that has good stability over time and maintains a transparent appearance even when the peptides are blended at high concentrations, and have thus completed the present invention.

[0011] The first means of the present invention for solving the above problems is a clear liquid cosmetic preparation that is inhibited from precipitating in a liquid, characterized by containing (a) one or two of palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine and palmitoyl dipeptide-5 diaminohydroxybutyric acid, and (b) hydroxypropyl methylcellulose stearoxy ether.

[0012] A second aspect of the present invention for solving the above problems is the clear liquid cosmetic preparation according to the first aspect of the present invention, characterized in that the total amount of component (a) blended is 0.001 to 0.2 mass % and the total amount of component (b) blended is 0.01 to 1 mass %.

[0013] The third aspect of the present invention for solving the above problems is a clear liquid cosmetic preparation according to the first or second aspect of the present invention, which can be prepared by blending optional ingredients into the composition. The optional ingredients are blended into the composition to an extent that does not impair the transparency of the clear liquid cosmetic preparation. [Effects of the Invention]

[0014] The present invention makes it possible to provide a transparent cosmetic preparation that is free from component precipitation and has excellent stability over time, even when the peptide is incorporated at a high concentration. Furthermore, the present invention makes it possible to incorporate any component as long as it does not impair transparency, thereby greatly expanding the scope of formulation design for transparent liquid cosmetic preparations that incorporate the peptide at a high concentration. DETAILED DESCRIPTION OF THE INVENTION

[0015] The following describes embodiments of the present invention. However, the present invention is not limited to these examples, and various modifications can be made without departing from the spirit of the present invention.

[0016] Palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine and palmitoyl dipeptide-5 diaminohydroxybutyric acid used in the present invention are classified as synthetic peptides formed by condensing specific amino acids. Some of these peptides are already commercially available, and such commercially available products can be purchased and used. A suitable example of such a commercially available product is "SYN-TACKS" (manufactured by DSM Co., Ltd., Japan).

[0017] The total amount of palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine and palmitoyl dipeptide-5 diaminohydroxybutyric acid used in the present invention in the liquid cosmetic is preferably 0.001 to 0.2% by mass. Specific amounts of the peptides are 0.001%, 0.003%, 0.005%, 0.007%, 0.01%, 0.03%, 0.05%, 0.07%, 0.1%, 0.13%, 0.15%, 0.17%, and 0.2% by mass, or may be within a range between any two of these values. If the amount of such components is too small, the aforementioned effects on the skin may not be achieved. On the other hand, if the amount of such components is too large, the aforementioned effects may not be achieved in terms of appearance as a liquid cosmetic.

[0018] The hydroxypropyl methylcellulose stearoxy ether used in the present invention is classified as a thickener. It is obtained by introducing a hydrophobic group into hydroxypropyl methylcellulose and is used in cosmetics, quasi-drugs, and pharmaceuticals. Some hydroxypropyl methylcellulose stearoxy ethers are already commercially available, and such commercially available products can be purchased and used. Suitable examples of such commercially available products include "Sangelose (registered trademark) 60L," "Sangelose 60M," "Sangelose 90L," and "Sangelose 90M" (all manufactured by Daido Chemical Industry Co., Ltd., Japan).

[0019] The blending amount of hydroxypropyl methylcellulose stearoxy ether used in the present invention is preferably 0.01 to 1% by mass. Specific blending amounts of hydroxypropyl methylcellulose stearoxy ether are 0.01% by mass, 0.03% by mass, 0.05% by mass, 0.07% by mass, 0.1% by mass, 0.3% by mass, 0.5% by mass, 0.7% by mass, 0.1% by mass, 0.2% by mass, 0.4% by mass, 0.6% by mass, 0.8% by mass, and 1% by mass, and may be within a range between any two of these values. If the amount of this component is too small, the liquid cosmetic will not exhibit the above-mentioned effects in appearance, and if the amount is too large, the feel in use may be impaired.

[0020] The transparent cosmetic preparation of the present invention may contain one or more aqueous or oily components commonly used in the cosmetic field, as needed. Examples of aqueous and oily components include, but are not limited to, moisturizers, water-soluble polymers, surfactants, solid, semi-solid, and liquid oils, higher alcohols, oil-soluble gelling agents, clay minerals, resins, film-forming agents, UV absorbers, powders, pigments, dyes, coloring materials, preservatives, antibacterial agents, antioxidants, salts, pH adjusters, chelating agents, fragrances, refreshing agents, antiperspirants, anti-inflammatory agents, skin activators, skin-beautifying ingredients, and various extracts.

[0021] The method for producing the transparent liquid cosmetic of the present invention is not particularly limited, and the cosmetic can be produced according to a method for producing ordinary cosmetics. Furthermore, the amount of the cosmetic of the present invention to be applied to the skin and the method of use are not particularly limited, and the cosmetic can usually be used by applying an appropriate amount several times a day.

[0022] The transparent liquid cosmetic preparation of the present invention refers to one having an absorbance of 0.05 or less at a wavelength of 660 nm.

[0023] The transparent liquid cosmetic of the present invention can be used, for example, but is not limited to, skin care products, hair products, makeup products, UV protection products, etc. The shape (form) of the product using the transparent liquid cosmetic of the present invention is also not particularly limited, and can be used in products such as liquid, emulsion, cream, solid, paste, gel, multi-layered, mousse, spray, etc. [Example]

[0024] The present invention will be further described below with reference to examples, but the present invention is not limited to these examples.

[0025] 1. Preparation of cosmetics to be used in evaluation tests Cosmetics used in the evaluation tests were prepared as Examples 1 to 8 shown in Table 1 below and Comparative Examples 1 to 12 shown in Table 2 below.

[0026] [Table 1]

[0027] [Table 2]

[0028] [Preparation of Cosmetics (Example 1)] An ethanol phase was prepared by mixing 42% by weight of absolute ethanol, 0.005% by weight of phytosphingosine, and 0.03% by weight of menthol. An aqueous phase was prepared by mixing 0.025% by weight of palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine, 0.025% by weight of palmitoyl dipeptide-5 diaminohydroxybutyric acid, 1.20% by weight of glycerin, 1.25% by weight of water, 0.2% by weight of PEG-40 hydrogenated castor oil, 0.1% by weight of hydroxypropyl methylcellulose stearoxy ether, and the remaining water. The ethanol phase and the aqueous phase were then mixed and thoroughly stirred, and then 0.2% by weight of hydrolyzed keratin and 0.8% by weight of water were added with continued stirring to obtain the cosmetic composition of Example 1.

[0029] [Preparation of Cosmetics (Example 2)] The cosmetic preparation of Example 2 was obtained in the same manner as in Example 1, except that the ingredients were 0.01% by mass of phytosphingosine, 0.05% by mass of palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine, 0.05% by mass of palmitoyl dipeptide-5 diaminohydroxybutyric acid, 2.4% by mass of glycerin, and 2.5% by mass of water.

[0030] [Preparation of Cosmetics (Example 3)] A cosmetic preparation of Example 3 was obtained in the same manner as in Example 1, except that the amount of hydroxypropyl methylcellulose stearoxy ether was 0.15% by mass.

[0031] [Preparation of Cosmetics (Example 4)] A cosmetic preparation of Example 4 was obtained in the same manner as in Example 2, except that the amount of hydroxypropyl methylcellulose stearoxy ether was 0.15% by mass.

[0032] [Preparation of Cosmetics (Example 5)] A cosmetic preparation of Example 5 was obtained in the same manner as in Example 1, except that the amount of hydroxypropyl methylcellulose stearoxy ether was changed to 0.2% by mass.

[0033] [Preparation of Cosmetics (Example 6)] A cosmetic preparation of Example 6 was obtained in the same manner as in Example 2, except that the amount of hydroxypropyl methylcellulose stearoxy ether was 0.2% by mass.

[0034] [Preparation of Cosmetics (Example 7)] A cosmetic preparation of Example 7 was obtained in the same manner as in Example 1, except that the amount of hydroxypropyl methylcellulose stearoxy ether was changed to 0.25% by mass.

[0035] [Preparation of Cosmetics (Example 8)] A cosmetic preparation of Example 8 was obtained in the same manner as in Example 2, except that the amount of hydroxypropyl methylcellulose stearoxy ether was 0.25% by mass.

[0036] [Preparation of Cosmetics (Comparative Example 1)] A cosmetic preparation of Comparative Example 1 was obtained in the same manner as in Example 1, except that hydroxypropyl methylcellulose stearoxy ether was not blended.

[0037] [Preparation of Cosmetic (Comparative Example 2)] A cosmetic preparation of Comparative Example 2 was obtained in the same manner as in Example 2, except that hydroxypropyl methylcellulose stearoxy ether was not blended.

[0038] [Preparation of Cosmetic (Comparative Example 3)] A cosmetic preparation of Comparative Example 3 was obtained in the same manner as in Example 1, except that 0.25% by mass of carbomer and 0.09% by mass of potassium hydroxide were blended in place of hydroxypropyl methylcellulose stearoxy ether.

[0039] [Preparation of Cosmetic (Comparative Example 4)] A cosmetic preparation of Comparative Example 4 was obtained in the same manner as in Example 2, except that 0.25% by mass of carbomer and 0.09% by mass of potassium hydroxide were blended in place of hydroxypropyl methylcellulose stearoxy ether.

[0040] [Preparation of Cosmetic (Comparative Example 5)] A cosmetic preparation of Comparative Example 5 was obtained in the same manner as in Example 1, except that 0.25% by mass of hydroxyethyl cellulose was blended in place of hydroxypropyl methylcellulose stearoxy ether.

[0041] [Preparation of Cosmetic (Comparative Example 6)] A cosmetic preparation of Comparative Example 6 was obtained in the same manner as in Example 2, except that 0.25% by mass of hydroxyethyl cellulose was blended in place of hydroxypropyl methylcellulose stearoxy ether.

[0042] [Preparation of Cosmetic (Comparative Example 7)] A cosmetic preparation of Comparative Example 7 was obtained in the same manner as in Example 1, except that 0.25% by mass of xanthan gum was blended in place of hydroxypropyl methylcellulose stearoxy ether.

[0043] [Preparation of Cosmetic (Comparative Example 8)] A cosmetic preparation of Comparative Example 8 was obtained in the same manner as in Example 2, except that 0.25% by mass of xanthan gum was blended in place of hydroxypropyl methylcellulose stearoxy ether.

[0044] [Preparation of Cosmetic (Comparative Example 9)] A cosmetic preparation of Comparative Example 3 was obtained in the same manner as in Example 1, except that 0.25% by mass of an (acrylates / C10-30 alkyl acrylate) crosspolymer and 0.09% by mass of potassium hydroxide were blended in place of hydroxypropyl methylcellulose stearoxy ether.

[0045] [Preparation of Cosmetic (Comparative Example 10)] A cosmetic preparation of Comparative Example 10 was obtained in the same manner as in Example 2, except that 0.25% by mass of (acrylates / alkyl acrylate (C10-30)) crosspolymer and 0.09% by mass of potassium hydroxide were blended in place of hydroxypropyl methylcellulose stearoxy ether.

[0046] [Preparation of Cosmetic (Comparative Example 11)] A cosmetic preparation of Comparative Example 11 was obtained in the same manner as in Example 1, except that 0.25% by mass of (PEG-240 / decyltetradeceth-20 / HDI) copolymer, 0.17% by mass of water, and 0.42% by mass of butylene glycol were added in place of hydroxypropyl methylcellulose stearoxy ether.

[0047] [Preparation of Cosmetic (Comparative Example 12)] A cosmetic preparation of Comparative Example 12 was obtained in the same manner as in Example 2, except that 0.25% by mass of (PEG-240 / decyltetradeceth-20 / HDI) copolymer, 0.17% by mass of water, and 0.42% by mass of butylene glycol were blended in place of hydroxypropyl methylcellulose stearoxy ether.

[0048] 2. Evaluation tests for water-based cosmetics (appearance and stability over time)

[0049] The cosmetic compositions of Examples 1 to 8 and Comparative Examples 1 to 12 were evaluated for appearance and stability over time.

[0050] 1) Evaluation of appearance The absorbance of the cosmetics of Examples 1 to 8 and Comparative Examples 1 to 12 was measured using a multimode microplate reader (SpectraMax iD3, Molecular Devices, LLC., California, USA), and their appearance was evaluated. 200 μL of each of the aqueous cosmetics of Examples 1 to 8 and Comparative Examples 1 to 12 was dispensed into a 96-well plate, and the absorbance at 660 nm was measured. The cosmetic appearance was evaluated based on the absorbance values ​​obtained and classified as transparent, translucent, or opaque according to the following criteria. Absorbance 0.05 or less: Transparent Absorbance 0.06 or more and less than 0.50: Slightly cloudy Absorbance 0.50 or more: Cloudy

[0051] 2) Stability over time The aqueous cosmetics of Examples 1 to 8 and Comparative Examples 1 to 12 were left to stand for one month in thermostatic chambers at -5°C, 25°C, 40°C (accelerated test conditions), and 50°C (stress test conditions), and then visually inspected for appearance and evaluated according to the following criteria. The accelerated and stress tests were carried out in accordance with the stability test guidelines set forth in a notification from the Ministry of Health, Labour and Welfare dated April 21, 1994. No change:○ Slight precipitation: △ Obvious precipitation: ×

[0052] 3. Results The absorbance was measured and the appearance and stability over time were evaluated for each of the aqueous cosmetics of Examples 1 to 8 and Comparative Examples 1 to 12. The evaluation results are shown in Table 3 below.

[0053] [Table 3]

[0054] When the active ingredients palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine and palmitoyl dipeptide-5 diaminohydroxybutyric acid were blended at high concentrations and hydroxypropyl methylcellulose stearoxy ether was further added, liquid cosmetics with a transparent appearance were obtained in all cases (see Examples 1 to 8 in Table 3). Furthermore, evaluation of the stability over time confirmed that these liquid cosmetics maintained their transparent appearance over a wide temperature range without any change over time (see Examples 1 to 8 in Table 3).

[0055] On the other hand, it has been confirmed that the following cases are inappropriate in any case.

[0056] When hydroxypropyl methylcellulose stearoxy ether was not blended, a liquid cosmetic preparation with a transparent appearance was obtained, but aggregation was observed over time, and it was confirmed that the preparation was unsuitable (see Comparative Examples 1 and 2 in Table 3).

[0057] It was confirmed that when carbomer was used instead of hydroxypropyl methylcellulose stearoxy ether, the liquid cosmetic became cloudy and could not have a transparent appearance, making it unsuitable (see Comparative Examples 1 and 2 in Table 3).

[0058] When hydroxyethyl cellulose was used instead of hydroxypropyl methylcellulose stearoxy ether, a liquid cosmetic preparation with a transparent appearance was obtained, but aggregation was observed over time, making it unsuitable (see Comparative Examples 5 and 6 in Table 3).

[0059] It was confirmed that when xanthan gum was used instead of hydroxypropyl methylcellulose stearoxy ether, the liquid cosmetic preparation became cloudy and did not have a transparent appearance, making it unsuitable (see Comparative Examples 7 and 8 in Table 3).

[0060] It was confirmed that when an (acrylates / C10-30 alkyl acrylate) crosspolymer was used instead of hydroxypropyl methylcellulose stearoxy ether, the liquid cosmetic preparation became cloudy and did not have a transparent appearance, making it unsuitable (see Comparative Examples 9 and 10 in Table 3).

[0061] When a (PEG-240 / decyltetradeceth-20 / HDI) copolymer was used instead of hydroxypropyl methylcellulose stearoxy ether, a liquid cosmetic preparation with a transparent appearance was obtained, but aggregation was observed over time, making it unsuitable (see Comparative Examples 11 and 12 in Table 3).

[0062] Thus, it has become clear that even when the active ingredients palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine and palmitoyl dipeptide-5 diaminohydroxybutyric acid are blended in at high concentrations, by further including hydroxypropyl methylcellulose stearoxy ether, it is possible to obtain a transparent cosmetic preparation that is free from precipitation of the active ingredients and has excellent stability over time. [Industrial Applicability]

[0063] The present invention makes it possible to provide a liquid cosmetic that maintains a stable, transparent appearance over a wide temperature range for a long period of time, even when it contains a high amount of one or both of palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine and palmitoyl dipeptide-5 diaminohydroxybutyric acid.

Claims

1. (a) containing one or two of palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine and palmitoyl dipeptide-5 diaminohydroxybutyric acid; (b) Hydroxypropyl methylcellulose stearoxy ether A transparent liquid cosmetic preparation characterized in that precipitation in the liquid is inhibited.

2. The transparent liquid cosmetic preparation according to claim 1, characterized in that the total amount of component (a) is 0.001 to 0.2% by mass, and the total amount of component (b) is 0.01 to 1% by mass.

3. 3. The transparent liquid cosmetic according to claim 1, which can be prepared by blending any desired ingredients into the composition.

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