Method for inspecting and manufacturing metal package container, method for manufacturing package body, package container assembly and package body assembly

Abstract

To provide a method for inspecting and manufacturing a metal package container capable of reducing the leakage risk of a specific content, such as a composition including highly unsaturated fatty acid alkyl ester as a main component.SOLUTION: A method for inspecting and manufacturing a metal package container comprises: molding and seam-welding a sheet metal to form a trunk; attaching a top plate and a bottom plate to the trunk to form the package container; and performing burr inspection for inspecting the level of a burr to the seam part of the trunk.SELECTED DRAWING: Figure 1

Description

[Technical Field]

[0001] The present invention relates to a method for inspecting and manufacturing metal packaging containers, a method for manufacturing packaging bodies, and a packaging container assembly and a packaging assembly. The present invention also relates to a method for using indicators to adjust the manufacturing method of packaging containers and packaging bodies. [Background technology]

[0002] Conventionally, in the production management of metal packaging containers such as drums, pre-shipment inspections have included a visual appearance inspection of the seam immediately after welding the body of the packaging container, and an airtightness inspection of the packaging container.

[0003] For example, Patent Document 1 discloses a method for inspecting the airtightness of a sealed drum placed in an airtight chamber. More specifically, the method of Patent Document 1 is a method for inspecting the airtightness of a sealed drum, in which the drum includes a cylindrical body, a bottom plate that closes the bottom opening of the body with a lower chime, and a top plate that closes the top opening of the body with an upper chime. This airtightness inspection method includes a vacuuming step for simultaneously evacuating the interior of the drum and the chamber to create a vacuum; a pressing step for pressing and holding the bottom plate and the top plate together after the vacuuming step; a high-pressure sealing step for sealing helium gas into the drum until the pressure reaches atmospheric pressure or higher after the pressing step; and a micro-leak inspection step for inspecting for helium gas leaks from the drum into the chamber after the high-pressure sealing step. The method of Patent Document 1 enables highly accurate airtightness inspection of a drum at the micro-leak level. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] Japanese Patent Application Publication No. 2016-080438 Summary of the Invention [Problem to be solved by the invention]

[0005] However, the present inventors have discovered a problem in that even packaging containers that pass a helium leak test, which is an airtightness test method with particularly high detection sensitivity, may still leak when certain contents are stored in them, such as a composition containing a highly unsaturated fatty acid alkyl ester as a main component.

[0006] The present invention aims to improve the above situation, and its object is to provide a method for inspecting and manufacturing a metal packaging container that reduces the risk of leakage of a specific content, such as a composition containing a highly unsaturated fatty acid alkyl ester as a main component.

[0007] Another object of the present invention is to provide a method for producing a package that reduces the risk of leakage of a specific content, such as a composition containing a highly unsaturated fatty acid alkyl ester as a main component.

[0008] It is yet another object of the present invention to provide a packaging container assembly and a packaging assembly in which the risk of leakage of a specific content is reduced. Here, the specific content may be, for example, a composition containing a highly unsaturated fatty acid alkyl ester as a main component.

[0009] Yet another object of the present invention is to provide a method for using an indicator to adjust a manufacturing method of a packaging container for storing a composition containing a highly unsaturated fatty acid alkyl ester as a main component.

[0010] Yet another object of the present invention is to provide a method for using an indicator to adjust a manufacturing method for a package containing a composition containing a highly unsaturated fatty acid alkyl ester as a main component. [Means for solving the problem]

[0011] The present invention that achieves the above object is as follows.

[0012] <Aspect 1> A method for inspecting metal packaging containers, comprising: forming a body by forming and seam welding sheet metal, and then attaching a top plate and a bottom plate to the body to form the packaging container, and then performing a burr inspection to inspect the seam portion of the body for the degree of burrs. Testing method. <Aspect 2> 2. The inspection method of claim 1, wherein the degree of the burr is based on a size of the burr. <Aspect 3> 3. The inspection method according to claim 1, wherein the burr inspection is performed visually. <Aspect 4> 4. The inspection method according to any one of aspects 1 to 3, wherein the burr inspection includes using a limit sample as a reference. <Aspect 5> A method for manufacturing a metal packaging container, forming and seam welding the sheet metal to form the fuselage; Attaching a top plate and a bottom plate to the body to form the packaging container; Conducting a burr inspection to inspect the degree of burrs on the seam portion of the body of the packaging container; and The packaging container that has passed the burr inspection is selected as a product that has passed the burr inspection. A method for manufacturing a metal packaging container, comprising: <Aspect 6> A manufacturing method according to aspect 5, wherein the burrs in the products that pass the burr inspection have a dimension of 1.3 mm or less. <Aspect 7> conducting a gas-tight inspection of the packaging container; Selecting the packaging container that has passed the airtightness test as an airtightness test-passed product; and The burr inspection is carried out on the products that have passed the airtightness inspection. 7. The method of claim 5 or 6, comprising: <Aspect 8> The inspection method according to any one of Aspects 1 to 4, or the production method according to any one of Aspects 5 to 7, wherein the packaging container is for storing a composition containing a highly unsaturated fatty acid alkyl ester as a main component. <Aspect 9> Contains over 100 metal packaging containers, For 98% or more of the 100 or more metal packaging containers, the dimension of the burr at the seam of the body of the packaging container is 1.3 mm or less, and The packaging container is for storing a composition containing a highly unsaturated fatty acid alkyl ester as a main component. Packing container assembly. <Aspect 10> containing 200 or more of said packages, and For 98% or more of the 200 or more packaging containers, the dimension of the flash at the seam of the body of the packaging container is 1.3 mm or less. A packaging container assembly according to embodiment 9. <Aspect 11> 11. The packaging container assembly of claim 9 or 10, wherein the packaging container assembly is made up of continuously manufactured packaging containers. <Aspect 12> A packing container assembly including 100 or more metal packing containers, wherein 98% or more of the 100 or more packing containers have a burr dimension of 1.3 mm or less at a seam portion of a body of the packing container; and A composition containing, as a main component, a highly unsaturated fatty acid alkyl ester contained in each of the assembly of packaging containers. A packaging assembly comprising: <Aspect 13> containing 200 or more of said packages, and For 98% or more of the 200 or more packaging containers, the dimension of the flash at the seam of the body of the packaging container is 1.3 mm or less. 13. The packaging assembly of embodiment 12. <Aspect 14> A packaging assembly as described in aspect 12 or 13, wherein 98% or more of the packaging bodies constituting the packaging assembly are determined to be leak-free in a content leakage test conducted at least two weeks after the composition is stored. <Aspect 15> 15. The packaging assembly according to any one of aspects 12 to 14, wherein the packaging assembly is made up of continuously manufactured packaging bodies. <Aspect 16> A method for producing a package, the method comprising: placing a composition containing a highly unsaturated fatty acid alkyl ester as a main component in the packaging container produced by the method according to any one of aspects 5 to 8. <Aspect 17> A method for manufacturing a package, comprising: A composition containing a highly unsaturated fatty acid alkyl ester as a main component is placed in the packaging container produced by the method according to any one of aspects 5 to 8, thereby obtaining a packaged body before leakage inspection. After two weeks or more have passed since the composition was stored, the unleaked package is subjected to a leak test; and The package that has passed the leakage test is selected as a product that has passed the leakage test. A method for manufacturing a package, comprising: <Aspect 18> A method for manufacturing a package, comprising: forming and seam welding the sheet metal to form the fuselage; Attaching a top plate and a bottom plate to the body to form a packaging container; storing a composition containing a highly unsaturated fatty acid alkyl ester as a main component in the packaging container to obtain a packaged body before leakage inspection; After two weeks or more have passed since the composition was stored, the unleaked package is subjected to a leak test; and The package that has passed the leakage test is selected as a product that has passed the leakage test. A method for manufacturing a package, comprising: <Aspect 19> A method for using an indicator to adjust a manufacturing method of a packaging container for storing a composition containing a highly unsaturated fatty acid alkyl ester as a main component, comprising: The indicator includes at least the result of a burr inspection of the packaging container; and The burr inspection includes inspecting the degree of burrs on a seam portion of a body of the packaging container after the top plate and the bottom plate are attached to the body to form the packaging container. How to use the indicator. <Aspect 20> A method for using an indicator to adjust a manufacturing method of a packaged body containing a composition containing a highly unsaturated fatty acid alkyl ester as a main component, comprising: The indicator includes at least the result of a leak test of the package; and The leakage inspection includes inspecting the uninspected package for leakage two weeks or more after the composition has been stored. How to use the indicator. <Aspect 21> A composition containing, as a main component, the highly unsaturated fatty acid alkyl ester contained in the packaging assembly according to any one of aspects 12 to 15; or A composition containing, as a main component, the highly unsaturated fatty acid alkyl ester contained in a package produced by the production method according to any one of aspects 16 to 18. A pharmaceutical composition comprising as an active ingredient. <Aspect 22> 22. The pharmaceutical composition according to aspect 21, which is an agent for treating or preventing at least one disease selected from the group consisting of arteriosclerosis, cerebral infarction, myocardial infarction, thrombosis, lifestyle-related diseases, allergies, inflammatory diseases, and cancer. [Effects of the Invention]

[0013] According to one aspect of the present invention, there are provided a method for inspecting and manufacturing a metal packaging container that reduces the risk of leakage of a specific content, such as a composition containing a highly unsaturated fatty acid alkyl ester as a main component.

[0014] According to another aspect of the present invention, a method for manufacturing a package that reduces the risk of leakage of a specific content can be provided. Here, the specific content can be, for example, a composition containing a highly unsaturated fatty acid alkyl ester as a main component.

[0015] According to another aspect of the present invention, it is possible to provide a packaging container assembly and a packaging assembly in which the risk of leakage of a specific content is reduced. Here, the specific content can be, for example, a composition containing a highly unsaturated fatty acid alkyl ester as a main component.

[0016] Furthermore, according to one aspect of the present invention, a method for using an indicator to adjust a manufacturing method of a packaging container for storing a composition containing a highly unsaturated fatty acid alkyl ester as a main component can be provided.

[0017] Furthermore, according to one aspect of the present invention, a method for using an indicator to adjust a manufacturing method for a package containing a composition containing a highly unsaturated fatty acid alkyl ester as a main component can be provided. [Brief explanation of the drawings]

[0018] [Figure 1] FIG. 1 is a process diagram showing one embodiment of the method for inspecting metal packaging containers according to the present invention. [Figure 2] FIG. 2 is a schematic diagram showing one embodiment of the packaging container formed in step S10. [Figure 3] FIG. 3 is a process diagram showing one embodiment of the method for producing a packaging container of the present invention. [Figure 4] FIG. 4 is a process diagram showing another embodiment of the method for producing a packaging container of the present invention. [Figure 5] FIG. 5 is a process diagram showing one embodiment of the second manufacturing method of the package of the present invention. [Figure 6] FIG. 6 is a process diagram showing one embodiment of the third method for producing a package according to the present invention. DETAILED DESCRIPTION OF THE INVENTION

[0019] Hereinafter, embodiments of the present invention will be described in detail with reference to the drawings. For the sake of convenience, descriptions of parts that overlap in each embodiment will be omitted. Not all components of the embodiments are essential, and some components may be omitted. However, the embodiments described below are merely examples of the present invention and do not limit the present invention.

[0020] <Inspection method for metal packaging containers> forming a body by forming and seam welding sheet metal, and then attaching a top plate and a bottom plate to the body to form a packaging container, and then performing a burr inspection to inspect the seam portion of the body for the degree of burrs. Inspection method is.

[0021] In one aspect of the present invention, the inspection method performs burr inspection on metal packaging containers, thereby reducing the risk of leakage of specific contents even when the specific contents are stored in the containers. Here, the specific contents include, for example, a composition containing a highly unsaturated fatty acid alkyl ester as a main component.

[0022] In one aspect of the present invention, reducing the risk of leakage of the contents means that leakage is less likely to occur than in an aspect in which burr inspection is not performed, and preferably means that leakage does not occur.

[0023] Fig. 1 is a process diagram showing one embodiment of the metal packaging container inspection method of the present invention. As shown in Fig. 1, the metal packaging container inspection method of the present invention includes forming a body by forming and seam welding a metal sheet, attaching a top plate and a bottom plate to the body to form a packaging container (step S10), and then performing a burr inspection to inspect the seam of the body for the degree of burrs (step S20).

[0024] Fig. 2 is a schematic diagram showing one embodiment of the packaging container formed in step S10. As shown in Fig. 2, the packaging container 100 formed in step S10 has a top plate 11 and a bottom plate 12 attached to a body 10. Although not shown in Fig. 2, the packaging container 100 may further have a ring band attached to the body 10, and / or the outer surface of the packaging container 100 may be painted. However, it is preferable that the outer surface of the packaging container 100 be painted in order to make burr inspection easier.

[0025] Then, step S20 includes carrying out a burr inspection to inspect the seam portion 10a of the body 10 of the packaging container 100 for the degree of burrs.

[0026] In the present invention, the term "packaging container" refers to a container capable of storing contents, preferably an empty container that can be sealed after storing contents. For example, the packaging container may be an empty drum, specifically a tight-head drum. In the present invention, a "metal packaging container" (hereinafter also referred to as a "packaging container") refers to a packaging container manufactured primarily from metal. Here, the metal that is the primary material of the packaging container of the present invention is not particularly limited, and examples include iron and aluminum. Of these, iron is preferably used as the primary metal. The packaging container of the present invention may be manufactured using only one type of metal, an alloy manufactured using two or more types of metals, or an alloy manufactured using one or more types of metal and a non-metal. The packaging container of the present invention may be manufactured using an alloy such as steel or stainless steel. The packaging container of the present invention is preferably manufactured using steel. In addition, in the present invention, the term "sheet metal" refers to a plate-shaped member used to form the packaging container of the present invention, i.e., a plate-shaped member primarily made of the above-mentioned metal. In one embodiment of the present invention, the metal packaging container may have a layer containing a metal phosphate on its inner surface. Specifically, the metal phosphate may be iron phosphate or zinc phosphate. In another embodiment of the present invention, the metal packaging container may have a resin layer on the inner surface. Specifically, the resin layer may be an epoxy-based resin layer or a phenol-based resin layer.

[0027] In one embodiment of the present invention, the size of the packaging container is not particularly limited, and for example, the volume of the portion that accommodates the contents may be 10 L or more, 20 L or more, 40 L or more, 60 L or more, 80 L or more, 100 L or more, 150 L or more, 200 L or more, or 300 L or more, and may be 450 L or less, 400 L or less, 350 L or less, 300 L or less, 250 L or less, or 200 L or less. In addition, the shape of the packaging container of the present invention is not particularly limited, and may be, for example, cylindrical.

[0028] Furthermore, from the viewpoint of further exerting the advantages of the present invention, in one embodiment of the present invention, the packaging container is preferably one for storing a composition containing a highly unsaturated fatty acid alkyl ester as a main component.

[0029] In the present invention, the term "package" refers to the above-mentioned packaging container in which contents are stored. For example, the package may be a drum containing contents. In one embodiment of the present invention, the contents may be a composition containing a highly unsaturated fatty acid alkyl ester as a main component.

[0030] In one aspect of the present invention, "highly unsaturated fatty acid" refers to a fatty acid having three or more double bonds, a type of unsaturated bond, particularly a fatty acid having 18 or more carbon atoms and three or more double bonds. Furthermore, highly unsaturated fatty acids may be, for example, fatty acids having 20 or more carbon atoms and three or more or four or more double bonds, or fatty acids having 20 or more carbon atoms and five or more double bonds. For example, the number of carbon atoms in highly unsaturated fatty acids may be 15 or more, 16 or more, 17 or more, 18 or more, 19 or more, or 20 or more, and may be 30 or less, 28 or less, 26 or less, 24 or less, or 22 or less. For example, the number of double bonds in highly unsaturated fatty acids may be 3 or more, 4 or more, or 5 or more, and may be 8 or less, 7 or less, or 6 or less.

[0031] Specific examples of highly unsaturated fatty acids include α-linolenic acid (18:3 n-3), γ-linolenic acid (18:3 n-6), dihomo-γ-linolenic acid (20:3 n-6), arachidonic acid (20:4 n-6), eicosapentaenoic acid (20:5 n-3, hereinafter also abbreviated as "EPA"), docosapentaenoic acid (22:5 n-6), and docosahexaenoic acid (22:6 n-3, hereinafter also abbreviated as "DHA").

[0032] In the present invention, the "highly unsaturated fatty acid alkyl ester" is not particularly limited, and examples thereof include C1-C6 alkyl esters of the above-mentioned highly unsaturated fatty acids. Specifically, it may be an ethyl ester. Therefore, in the present invention, specific examples of the "highly unsaturated fatty acid alkyl ester" include eicosapentaenoic acid ethyl ester (hereinafter also abbreviated as "EPA-E") and omega-3 fatty acid ethyl esters (OMEGA-3-ACID ETHYL ESTERS). Here, the omega-3 fatty acid ethyl ester is a highly unsaturated fatty acid ethyl ester containing EPA-E and docosahexaenoic acid ethyl ester (hereinafter also abbreviated as "DHA-E") as main components.

[0033] In one embodiment of the present invention, a "composition containing a highly unsaturated fatty acid alkyl ester as a primary component" may be composed of one type of highly unsaturated fatty acid alkyl ester as a primary component, or a mixture of two or more types of highly unsaturated fatty acid alkyl esters as a primary component. In one embodiment of the present invention, the composition refers to a composition in which the total proportion of highly unsaturated fatty acids in the constituent fatty acids of the composition is 50 area% or more, 60 area% or more, 70 area% or more, 80 area% or more, 84 area% or more, 90 area% or more, 95 area% or more, or 96.5 area% or more. For example, this composition may be a composition containing EPA-E as a primary component, or a composition containing omega-3 fatty acid ethyl as a primary component. Here, in a composition containing EPA-E as a primary component, the proportion of EPA in the constituent fatty acids may be 50 area% or more, 60 area% or more, 70 area% or more, 80 area% or more, 84 area% or more, 90 area% or more, 95 area% or more, or 96.5 area% or more, preferably 96.5 area% or more. In a composition containing omega-3 fatty acid ethyl as the main component, the total proportion of EPA and DHA in the constituent fatty acids may be 50 area% or more, 60 area% or more, 70 area% or more, 80 area% or more, 84 area% or more, 90 area% or more, 95 area% or more, or 96.5 area% or more, preferably 84 area% or more. Note that "area%" here refers to a value calculated based on the gas chromatography analysis conditions and analysis method described in WO 2020 / 122167. In the oil chemistry field, "area%" is used as almost synonymous with "weight%".

[0034] In one aspect of the present invention, a "composition containing a highly unsaturated fatty acid alkyl ester as a primary component" refers to a composition in which the total proportion of highly unsaturated fatty acid alkyl esters in the composition is 50% by weight or more, 60% by weight or more, 70% by weight or more, 80% by weight or more, 84% by weight or more, 90% by weight or more, 95% by weight or more, or 96.5% by weight or more. For example, this composition may be a composition containing EPA-E as a primary component or a composition containing omega-3 fatty acid ethyl ester as a primary component. Here, in a composition containing EPA-E as a primary component, the proportion of EPA in the composition may be 50% by weight or more, 60% by weight or more, 70% by weight or more, 80% by weight or more, 84% by weight or more, 90% by weight or more, 95% by weight or more, or 96.5% by weight or more, preferably 96.5% by weight or more. In a composition containing omega-3 fatty acid ethyl as the main component, the total proportion of EPA and DHA in the composition may be 50% by weight or more, 60% by weight or more, 70% by weight or more, 80% by weight or more, 84% by weight or more, 90% by weight or more, 95% by weight or more, or 96.5% by weight or more, and is preferably 84% by weight or more.

[0035] In one embodiment of the present invention, "burrs" refer to variations in the shape of the edge of the outer sheet metal at the seam of the body of the packaging container. For example, variations in the shape of the edge of the outer sheet metal at seam 10a shown in Fig. 2 can be cited. More specifically, in one embodiment, "burrs" refer to variations in the shape of the edge, which is uneven in the direction perpendicular to the weld line and / or in the circumferential direction of the packaging container.

[0036] In one aspect of the present invention, "burr inspection" refers to inspecting the degree of burrs in the seam of the body of a packaging container. Here, the degree of burrs may be based on the dimensions of the burrs. Here, "burr dimensions" refers to the sum of the distance from a straight line average line to the shape of the edge of the outer metal sheet of the seam, and the distance from the average line to the highest peak and the distance from the average line to the lowest valley. In the present invention, "burr dimensions" can be determined by a method based on the maximum height Ry in surface roughness (JIS B 0601:1994, JIS B 0031:1994).

[0037] Although JIS B 0051:2004 defines "burr dimensions," these burrs are generated during machining or molding processes. In other words, the shape of the "burrs" in the present invention differs from the shape of the "burrs" in JIS B 0051:2004, and therefore, naturally, the "burr dimensions" according to the present invention differ from the "burr dimensions" defined in JIS B 0051:2004.

[0038] In one aspect of the present invention, the burr inspection may be performed visually. In another aspect of the present invention, the burr inspection may be performed using a shape measuring machine.

[0039] The burr inspection may also include using a limit sample as a reference. The limit sample may be created, for example, by cutting out a seam portion of a packaging container having a burr. In one embodiment of the present invention, the burr dimension of the limit sample may be 1.3 mm. In the present invention, a packaging container having a smaller burr than the limit sample may be selected.

[0040] <Method for manufacturing metal packaging containers> A method for manufacturing a metal packaging container according to one aspect of the present invention (hereinafter also referred to as a "manufacturing method for a packaging container") includes: forming and seam welding the sheet metal to form the fuselage; Attaching a top plate and a bottom plate to the body to form a packaging container; Conducting a burr inspection to check the degree of burrs on the seam of the body of the packaging container; Packaging containers that pass the burr inspection are selected as burr-inspection-passing products. A method for manufacturing a metal packaging container, is.

[0041] In the method for manufacturing a packaging container according to one aspect of the present invention, the risk of leakage can be reduced even when specific contents are stored in the packaging container by conducting a burr inspection and selecting products that pass the burr inspection. Here, the specific contents can include, for example, a composition containing a highly unsaturated fatty acid alkyl ester as a main component.

[0042] Fig. 3 is a process diagram showing one embodiment of the method for manufacturing a packaging container of the present invention. As shown in Fig. 3, the method for manufacturing a packaging container of one embodiment of the present invention may include forming a body by forming and seam-welding a metal plate (step S1), attaching a top plate and a bottom plate to the body to form a packaging container (step S2), conducting a burr inspection to inspect the seam portion of the body of the packaging container for the degree of burrs (step S3), and selecting a packaging container that passes the burr inspection as a product that has passed the burr inspection (step S4).

[0043] In step S1, the forming of the sheet metal is not particularly limited and can be performed, for example, by pressing, etc., according to the shape, volume, etc., of the target packaging container. Furthermore, the seam welding is not particularly limited and can be performed by well-known seam welding. Furthermore, although not essential, it is preferable to press the seam after forming the body to flatten it.

[0044] In step S2, the top and bottom plates are attached to the body using, for example, a sealant. Although not essential, it is preferable to seam the edges after attaching the top and bottom plates to the body. The seamed edges are called seamed portions, also called chimes. The shape of the chimes is not particularly limited, and may be, for example, a triple seam. More specifically, it may be a triple seam round seam.

[0045] Note that the burr inspection in step S3 can be performed by referring to the above-mentioned "Metal Packaging Container Inspection Method" as appropriate, and therefore a description thereof will be omitted here.

[0046] In step S4, the selection of burr-accepting products can be based on, for example, the burr dimensions described above. Here, the specific value of the burr dimensions of burr-accepting products is not particularly limited, and may be, for example, 1.3 mm or less, 1.2 mm or less, 1.1 mm or less, 1.0 mm or less, 0.9 mm or less, 0.8 mm or less, 0.7 mm or less, 0.6 mm or less, 0.5 mm or less, 0.4 mm or less, 0.3 mm or less, 0.2 mm or less, 0.1 mm or less, or 0.0 mm. Here, a burr dimension of 0.0 mm means that there is substantially no burr.

[0047] The method for manufacturing a packaging container of the present invention can further include other steps in addition to the above-mentioned steps S1 to S4. For example, the other steps include subjecting the packaging container to an airtightness test using gas (step S3a), and selecting packaging containers that pass the airtightness test as products that have passed the airtightness test (step S3b). More specifically, the method will be described with reference to FIG. 4.

[0048] Fig. 4 is a process diagram showing another embodiment of the manufacturing method for a packaging container of the present invention. As shown in Fig. 4, the manufacturing method for a packaging container of another embodiment of the present invention may include forming and seam-welding a metal sheet to form a body (step S1), attaching a top plate and a bottom plate to the body to form a packaging container (step S2), conducting an airtightness test on the packaging container using gas (step S3a), selecting the packaging container that has passed the airtightness test as a product that has passed the airtightness test (step S3b), conducting a burr test to check the degree of burrs on the seam of the body of the product that has passed the airtightness test (step S3'), and selecting the packaging container that has passed the burr test as a product that has passed the burr test (step S4).

[0049] In step S3a, the airtightness test may be performed by an air test or a helium leak test, which is preferable because it has higher detection sensitivity than the air test.

[0050] The air test can be performed, for example, by sealing compressed gas in a packaging container, submerging it in water for a predetermined period of time, and observing whether or not blisters form. Specifically, the air test can be performed by sealing compressed air in a packaging container, submerging it in water for 2 to 10 minutes, or 3 to 5 minutes, and observing whether or not blisters form.

[0051] The helium leak test can be carried out, for example, by injecting helium gas into a packaging container, and then reducing the pressure outside the packaging container in a vacuum chamber, thereby checking whether or not there is a helium gas leak.

[0052] The product that passes the airtightness inspection in step S3b refers to a packaging container that has passed the airtightness inspection and is free of leaks.

[0053] 《Packaging container assembly》 A packaging container assembly according to one aspect of the present invention comprises: Contains 100 or more metal packaging containers, and For 98% or more of 100 or more metal packaging containers, the dimension of the burr on the seam of the body of the packaging container is 1.3 mm or less, and The packaging container is for storing a composition containing a highly unsaturated fatty acid alkyl ester as a main component. packaging container assembly is.

[0054] By using the packaging container assembly according to one embodiment of the present invention, the risk of leakage can be reduced even when a composition containing a highly unsaturated fatty acid alkyl ester as a main component is stored.

[0055] More specifically, a packaging container assembly according to one embodiment of the present invention may include 100 or more, 120 or more, 150 or more, 180 or more, or 200 or more packaging containers. Furthermore, the upper limit of the number of packaging containers included in the packaging container assembly is not particularly limited, and may be, for example, 5,000 or less, 1,000 or less, 500 or less, or 300 or less. Furthermore, for 98% or more, 99% or more, 99.5% or more, or 100% of the packaging containers included in the packaging container assembly according to one embodiment of the present invention, the dimension of the flash at the seam portion of the body of the packaging container may be 1.3 mm or less. More specifically, the dimension of the burr may be, for example, 1.3 mm or less, 1.2 mm or less, 1.1 mm or less, 1.0 mm or less, 0.9 mm or less, 0.8 mm or less, 0.7 mm or less, 0.6 mm or less, 0.5 mm or less, 0.4 mm or less, 0.3 mm or less, 0.2 mm or less, 0.1 mm or less, or 0.0 mm. Here, a burr dimension of 0.0 mm means that there is substantially no burr.

[0056] A packaging container assembly according to one aspect of the present invention is an assembly of packaging containers that are continuously manufactured. Here, the term "continuously manufactured" means that, during the manufacturing of the packaging containers relating to the packaging container assembly, all of the packaging containers are selected as products that pass the burr inspection, and no rejected products are selected.

[0057] Packaging assembly A packaging assembly according to one aspect of the present invention comprises: A packing container assembly containing 100 or more metal packing containers, in which 98% or more of the 100 or more packing containers have a burr size of 1.3 mm or less at the seam of the packing container body; and A composition containing a highly unsaturated fatty acid alkyl ester as a main component, which is contained in each of the packaging container assemblies. A package assembly including is.

[0058] According to the package assembly of one aspect of the present invention, it is possible to reduce the risk of leakage of the contained composition, that is, the composition containing a highly unsaturated fatty acid alkyl ester as a main component.

[0059] More specifically, a packaging assembly according to one embodiment of the present invention may include 100 or more, 120 or more, 150 or more, 180 or more, or 200 or more packaging containers. Furthermore, the upper limit of the number of packaging containers included in a packaging assembly according to one embodiment of the present invention is not particularly limited, and may be, for example, 5,000 or less, 1,000 or less, 500 or less, or 300 or less. Furthermore, for 98% or more, 99% or more, 99.5% or more, or 100% of the packaging containers included in a packaging assembly according to one embodiment of the present invention, the flash dimension of the seam portion of the body of the packaging container may be 1.3 mm or less. More specifically, the dimension of the burr may be, for example, 1.3 mm or less, 1.2 mm or less, 1.1 mm or less, 1.0 mm or less, 0.9 mm or less, 0.8 mm or less, 0.7 mm or less, 0.6 mm or less, 0.5 mm or less, 0.4 mm or less, 0.3 mm or less, 0.2 mm or less, 0.1 mm or less, or 0.0 mm. Here, a burr dimension of 0.0 mm means that there is substantially no burr.

[0060] Furthermore, 98% or more of the packages constituting the package assembly of one embodiment of the present invention can be determined to be leak-free in a content leakage test conducted two weeks or more after the composition has been stored in them. More specifically, for example, 98% or more, 99% or more, 99.5% or more, or 100% of the packages constituting the package assembly of one embodiment of the present invention can be determined to be leak-free in a content leakage test conducted two weeks or more after the composition has been stored in them. In this way, a determination of "no content leakage" after two weeks or more can be made, which is preferable because it allows the package assembly to be manufactured, shipped, and even used without leakage. The period from storage of the composition until a content leakage inspection may be, for example, 2 weeks or more, 4 weeks or more, 8 weeks or more, 10 weeks or more, 12 weeks or more, or 16 weeks or more, or may be 30 weeks or less, 25 weeks or less, 20 weeks or less, 18 weeks or less, 16 weeks or less, 12 weeks or less, 10 weeks or less, 8 weeks or less, 4 weeks or less, or 2 weeks or less. The content leakage inspection may be conducted before shipping the package assembly. The period from this leakage inspection until shipping may be, for example, 4 weeks or less, 2 weeks or less, or 1 week or less. The number of content leakage inspections is not particularly limited and may be, for example, 1, 2, 3, or 4 times. The number of times may be 1 or more, 2 or more, 3 or more, and / or 4 or less, or 3 or less.

[0061] In one embodiment of the present invention, the method for inspecting for content leakage is not particularly limited, and can be determined visually as appropriate based on the properties of the content, etc. For example, when a composition containing a highly unsaturated fatty acid alkyl ester such as EPA-E as a main component is stored as the content, the leaked highly unsaturated fatty acid alkyl ester such as EPA-E is oxidized and turns yellow, so if there is a yellow coloration, it can be determined that there is content leakage, and if there is no yellow coloration, it can be determined that there is no content leakage.

[0062] A packaging assembly according to one aspect of the present invention is an assembly of packaging bodies made up of packaging bodies manufactured continuously. Here, "continuously manufactured" means that, during the manufacturing of the packaging bodies of the packaging assembly, all of the packaging bodies are selected as products that pass the burr inspection and / or the leak inspection, and no packaging bodies that fail the burr inspection and / or the leak inspection are selected.

[0063] <<Packaging manufacturing method>> In one aspect of the present invention, there is provided a method for producing a packaged body in which a composition containing a highly unsaturated fatty acid alkyl ester as a main component is stored in a packaging container. The method for producing the packaged body in this aspect may be any of the first to third production methods shown below. Furthermore, in the packaged body of one aspect of the present invention produced by any of the production methods, the risk of leakage of the composition containing a highly unsaturated fatty acid alkyl ester as a main component stored as the contents can be reduced.

[0064] The manufacturing method of the first aspect for manufacturing a package includes: A composition containing a highly unsaturated fatty acid alkyl ester as a main component is stored in the packaging container of this embodiment manufactured by the manufacturing method of the packaging container of one embodiment of the present invention described above. Includes:

[0065] The manufacturing method of the second aspect for manufacturing a package is as follows: A composition containing a highly unsaturated fatty acid alkyl ester as a main component is placed in the packaging container of this embodiment manufactured by the above-mentioned manufacturing method of a packaging container of one embodiment of the present invention, thereby obtaining a packaged body before leakage inspection; The untested package is subjected to a leak test at least two weeks after the composition is stored; and Selecting packages that pass the leak test as leak-test passing products Includes:

[0066] Fig. 5 is a process diagram showing one embodiment of a second manufacturing method of a package of the present invention. As shown in Fig. 5, this second method may include obtaining a package before a leak test by storing a composition containing a highly unsaturated fatty acid alkyl ester as a main component in a packaging container of this embodiment manufactured by the manufacturing method of a packaging container of one embodiment of the present invention described above (step S100), leak testing the package before a leak test two weeks or more after storing the composition (step S200), and selecting the package that passed the leak test as a product that passed the leak test (step S300).

[0067] Furthermore, in step S200, the period from storage of a composition containing a highly unsaturated fatty acid alkyl ester as a main component until content leakage testing may be, for example, 2 weeks or more, 4 weeks or more, 8 weeks or more, 10 weeks or more, 12 weeks or more, or 16 weeks or more, or may be 30 weeks or less, 25 weeks or less, 20 weeks or less, 18 weeks or less, 16 weeks or less, 12 weeks or less, 10 weeks or less, 8 weeks or less, 4 weeks or less, or 2 weeks or less.

[0068] In step S300, a product that has passed the leakage inspection refers to a package that has undergone the leakage inspection and has no leakage of the contents.

[0069] A third embodiment of the manufacturing method for manufacturing a packaging body includes: forming and seam welding the sheet metal to form the fuselage; Attaching a top plate and a bottom plate to the body to form a packaging container; storing a composition containing a highly unsaturated fatty acid alkyl ester as a main component in a packaging container to obtain a packaged body before a leakage inspection; The untested package is subjected to a leak test at least two weeks after the composition is stored; and Selecting packages that pass the leak test as leak-test passing products Includes:

[0070] Fig. 6 is a process diagram showing one embodiment of a third manufacturing method of a package of the present invention. As shown in Fig. 6, this third method may include forming and seam-welding sheet metal to form a body (step S1), attaching a top plate and a bottom plate to the body to form a packaging container (step S2), storing a composition containing a highly unsaturated fatty acid alkyl ester as a main component in the packaging container to obtain a pre-leak-tested package (step S101), leak-testing the pre-leak-tested package two weeks or more after storing the composition (step S200), and selecting the package that passed the leak test as a product that passed the leak test (step S300).

[0071] <<Method of using indicators to adjust manufacturing methods of packaging containers>> In one aspect of the present invention, it is possible to provide a guide for adjusting the manufacturing method of the packaging container.

[0072] A method of one aspect of the present invention using an index to adjust a manufacturing method of a packaging container includes: A method for using an indicator to adjust a manufacturing method of a packaging container for storing a composition containing a highly unsaturated fatty acid alkyl ester as a main component, comprising: The indicators include at least the results of a burr inspection of the packaging container, and The burr inspection includes inspecting the seam of the body of the packaging container for the degree of burrs after the top plate and the bottom plate are attached to the body to form the packaging container.

[0073] Furthermore, the indicators according to one aspect of the present invention may further include the welding conditions of the packaging container and / or the results of an airtightness inspection of the packaging container.

[0074] In addition, in one aspect of the present invention, the above description can be referred to for the burr inspection. In one aspect of the present invention, the result of the burr inspection may be the result of the burr inspection referred to in the above description. In one aspect of the present invention, the result of the burr inspection can be referred to in the above description of the product that passed the burr inspection.

[0075] How to use the indicators to adjust the manufacturing process of packaging In another aspect of the present invention, a method for using the indicator to adjust the manufacturing process of the package can be provided.

[0076] A method of using an index to adjust a manufacturing method of a package according to one aspect of the present invention includes: A method for using an indicator to adjust a manufacturing method of a packaged body containing a composition containing a highly unsaturated fatty acid alkyl ester as a main component, comprising: The indicators include at least the results of a leak test of the package, and The leak test includes testing the untested package for leaks two weeks or more after the composition is stored.

[0077] In addition, the indicators according to another aspect of the present invention may further include at least one result selected from the group consisting of the welding conditions of the packaging container, the result of a burr inspection of the packaging container, and the result of an airtightness inspection of the packaging container.

[0078] In another aspect of the present invention, the above description can be referenced for the leak test. In one aspect of the present invention, the results of the leak test may be the results of the leak test referenced in the above description. In one aspect of the present invention, the results of the leak test can be referenced for the above description of the product that passed the leak test.

[0079] <<Usage>> In one aspect of the present invention, the composition containing the highly unsaturated fatty acid alkyl ester as a main component contained in the above-described package assembly and / or the package produced by the above-described production method may be used, for example, as an oral preparation. Typical oral preparations include granules, tablets, capsules, and liquids. Applications of the composition of the present invention include, for example, foods and beverages (health foods, nutritional supplements, foods for specified health uses, supplements, dairy products, soft drinks, pet foods and beverages, livestock feed, etc.), pharmaceuticals, and quasi-drugs, with supplements and pharmaceuticals being particularly preferred. In addition to food ingredients or foods, the composition may also be used as an additive ingredient for animal feed. Therefore, in one aspect of the present invention, the composition containing the highly unsaturated fatty acid alkyl ester as a main component can be used as a material or active ingredient for these foods and beverages, pharmaceuticals, and quasi-drugs, and is preferably used in the production of these foods and beverages, pharmaceuticals, and quasi-drugs.

[0080] Pharmaceutical Composition In one aspect of the present invention, the present invention includes a pharmaceutical composition containing, as an active ingredient, a composition containing, as a main ingredient, a highly unsaturated fatty acid alkyl ester contained in the above-mentioned package assembly and / or the package produced by the above-mentioned production method. The content of the composition containing, as a main ingredient, a highly unsaturated fatty acid alkyl ester in the pharmaceutical composition is not particularly limited, but is preferably 25% by weight to 99% by weight, more preferably 50% by weight to 95% by weight.

[0081] The pharmaceutical composition can be used for the treatment or prevention of lifestyle-related diseases such as arteriosclerosis, cerebral infarction, myocardial infarction, thrombosis, and hyperlipidemia, as well as allergies, inflammatory diseases, and cancer, and can be used, for example, as a therapeutic agent for arteriosclerosis obliterans, a therapeutic agent for hyperlipidemia, etc.

[0082] In one embodiment of the present invention, the pharmaceutical composition may contain pharmaceutically acceptable additives in addition to the active ingredient. Pharmaceutical compositions containing such additives may also contain pharmaceutically acceptable excipients. The pharmaceutical composition may optionally contain known antioxidants, coating agents, gelling agents, flavoring agents, fragrances, preservatives, antioxidants, emulsifiers, pH adjusters, buffers, colorants, and the like. It is desirable to contain an effective amount of at least one antioxidant selected from the group consisting of butylated hydroxytoluene, butylated hydroxyanisole, propyl gallate, gallic acid, pharmaceutically acceptable quinones, ascorbic acid esters such as ascorbyl palmitate, and tocopherols.

[0083] The dosage form of the preparation varies depending on the form of the combined active ingredient and is not particularly limited, but oral preparations are preferred, and can be used in the form of, for example, tablets, film-coated tablets, capsules, microcapsules, granules, fine granules, powders, oral liquid preparations, syrups, jellies, or inhalants. In particular, oral administration in capsule form, such as soft capsules or microcapsules, is preferred. Oral administration in the form of enteric-coated or sustained-release preparations is also possible, and oral administration in the form of jellies is also preferred for dialysis patients, patients with swallowing difficulties, etc. The pharmaceutical composition of the present invention can be manufactured or formulated according to conventional methods.

[0084] One embodiment of the present invention includes administering a pharmaceutical composition to a subject suffering from or at risk of suffering from at least one disease selected from the group consisting of arteriosclerosis, cerebral infarction, myocardial infarction, thrombosis, lifestyle diseases, allergies, inflammatory diseases, and cancer, and includes a method for preventing, treating or alleviating the disease. The administration form may be oral administration or topical administration. The dosage may be an amount effective for treatment or prevention, and is appropriately set according to conditions such as the type of the target disease, the degree of symptoms, the age, weight and health status of the administration subject. For example, in the case of an adult, the pharmaceutical composition is administered orally or parenterally once a day or divided into 2 to 3 times or more at appropriate intervals, in an amount of 100 mg to 10 g / day, preferably 1 g to 6 g / day, more preferably 1.8 g, 2 g, 2.1 g, 2.4 g, 2.7 g, 3 g, or 4 g / day as the amount of the active ingredient.

[0085] As used herein, a therapeutic agent refers to a pharmaceutical composition used to suppress or alleviate the progression of such symptoms when symptoms due to a target disease are found. On the other hand, a prophylactic agent refers to a pharmaceutical composition used to suppress the onset of symptoms by administering it in advance when the onset of symptoms due to a target disease is expected. However, these terms are used in a complex manner depending on the timing of use or the symptoms at the time of use and are not construed in a limited sense.

Examples

[0086] The present invention will be described in more detail with reference to the following examples, but the present invention is not limited thereto.

[0087] <Method for preparing a composition containing EPA-E as a main component>[ Fish oil was ethyl esterified by a conventional method to prepare fish oil ethyl ester in which EPA-E in the fatty acid ethyl ester is 16 area% or more. Using a multi-stage rectification apparatus, the fish oil ethyl ester was continuously rectified under the conditions of a tower top pressure of 26.7 Pa or less and a temperature of 190 °C or less, and fractionated into an initial fraction, a main fraction, and a residual fraction to obtain the main fraction. Here, the initial fraction is a fraction with higher volatility than the main fraction and mainly contains ethyl esters of fatty acids with less than C 20 The main fraction mainly contains ethyl esters of fatty acids with C 20 and EPA-E in the fatty acid ethyl ester is 70 area% or more. The residual is a fraction with lower volatility than the main fraction and mainly contains ethyl esters of fatty acids with C 21 or more.

[0088] The obtained main fraction was purified by HPLC using octadecylated silica gel as a filler and methanol as a mobile phase to prepare a composition (hereinafter also referred to as "EPA-E composition") containing EPA-E as the main component with a proportion of EPA in the constituent fatty acids of 96.5 area% or more.

[0089] The preparation of the EPA-E composition can be carried out by referring to, for example, the methods described in JP-A-04-041457, JP-A-04-128250, and JP-A-05-222392.

[0090] <Method for Preparing a Glyceride Composition Containing DHA Triglyceride as the Main Component> Fish oil was deacidified, enzyme-treated, decolorized, and deodorized by a conventional method to prepare a glyceride composition (hereinafter also referred to as "glyceride composition") containing DHA triglyceride as the main component. The glyceride composition contains 73 to 78% by weight of triglyceride and 22 to 26% by weight of diglyceride in the composition. The proportion of DHA in the constituent fatty acids of the composition is 55 area% or more, and the proportion of EPA is 5 area% or more.

[0091] The enzyme treatment method for preparing the glyceride composition can be carried out with reference to the methods described in, for example, JP-A No. 2013-55893 and WO2011 / 149040.

[0092] <Production Example 1> A steel sheet (1.2 mm thick) was rolled into a cylindrical shape and seam welded to create the drum body. The steel sheet was then punched, and processing such as attaching a nozzle was performed to create the top and bottom plates. The body, top, and bottom plates were degreased and treated with a zinc phosphate coating. The treated top and bottom plates were fitted into the treated body and seamed to form a drum with a triple-seamed seam. The seamed portion is also called a chime, and in this manufacturing example, the chime is a triple-seamed round seam.

[0093] The exterior of the molded drums was coated with a resin-based paint at a film thickness of 10 μm using an airless gun. A helium leak test was conducted on the coated drums, and empty 200 L drums were produced that passed the airtightness test.

[0094] The helium leak test was conducted using the following leak detection device. More specifically, helium gas was injected into the drum, and then the outside of the drum was depressurized in the vacuum chamber of the leak detection device to detect any helium gas leaking from defective areas. Drums in which no helium gas leakage was detected were selected as having passed the airtightness test. Here, the leak inspection device was used with the settings described in the instruction manual that enable it to achieve a minimum φ30 μm detection capability certified by Yamaha Fine Technologies Co., Ltd.

[0095] (Leak inspection device for helium leak testing) Yamaha Fine Tech Co., Ltd. Product Name: Drum Leak Tester Detection capability: Minimum φ30μm The helium leak test is said to have 100 to 1,000 times the detection capability of conventional air tests.

[0096] A drum that had passed the airtightness test was filled with 180 kg of the EPA-E composition, and nitrogen was sealed inside, then the drum was sealed to produce a drum filled with the EPA-E composition according to Production Example 1. The proportion of EPA in the constituent fatty acids of the EPA-E composition was 96.5 area % or more. Immediately after filling, it was confirmed that the EPA-E composition had not leaked.

[0097] <Production Example 2> The exterior surfaces of the molded drums were painted in the same manner as in Production Example 1 above. A helium leak test was then conducted, and empty 200L drums that passed the airtightness test were selected. The selected drums were then inspected for burrs at the seams of the bodies using limit samples, and empty 200L drums that passed the burr test were produced. The drums were filled with 180 kg of the EPA-E composition, sealed with nitrogen, and sealed to produce drums filled with the EPA-E composition according to Production Example 2. The proportion of EPA in the constituent fatty acids of the EPA-E composition was 96.5% by area or more. It was confirmed that the EPA-E composition had not leaked immediately after filling.

[0098] Comparative Example 1 An empty 200 L drum that passed the airtightness test was produced in the same manner as in Production Example 1 above. Without conducting a burr inspection, the drum was filled with 180 kg of a glyceride composition containing DHA triglyceride as a main component (hereinafter also referred to as "glyceride composition"). The drum was then sealed with nitrogen and sealed to produce a drum filled with the glyceride composition of Comparative Example 1. The glyceride composition contained 73 to 78 wt % triglycerides and 22 to 26 wt % diglycerides. The proportion of DHA in the constituent fatty acids of the composition was 55 area % or more, and the proportion of EPA was 5 area % or more. It was confirmed that there was no leakage of the glyceride composition immediately after filling.

[0099] "evaluation" The drums filled with the EPA-E compositions or glyceride compositions prepared in Production Examples 1 and 2 were left standing at 15 to 30°C for 4 to 6 months. Thereafter, the presence or absence of leakage of the EPA-E compositions or glyceride compositions was confirmed. The results are shown in Table 1.

[0100] The presence or absence of leakage of the EPA-E composition or glyceride composition was determined by visually inspecting the seam welds and / or the top or bottom plate seams of the drum, and if yellow discoloration due to oxidized EPA-E or DHA triglyceride was detected, it was determined that leakage had occurred.

[0101] [Table 1]

[0102] As is clear from the results in Table 1, it was found that the EPA-E composition leaked from 4 out of 150 drums according to Production Example 1. In contrast, it was found that there was no leakage of the EPA-E composition from any of the 150 drums according to Production Example 2. It was also found that there was no leakage of the glyceride composition from any of the 150 drums according to Comparative Example 1. 《Reference example》 <Investigation of leaking drums> Regarding the drums of Production Example 1, the EPA-E composition was extracted from three of the drums in which leakage of the EPA-E composition had occurred, and the interior surfaces were washed with an alkaline detergent and dried. A burr inspection, a helium leak test, and a PT check (penetrant testing) were performed on the drums. The PT check was performed as follows.

[0103] (PT Check (penetrant testing)) The inside and outside of the drum were cleaned with a detergent (Color Check FR-Q, manufactured by Taseto Co., Ltd.), and a red penetrant (Color Check FP-S, manufactured by Taseto Co., Ltd.) was applied to the inside. Compressed air (30 kPa) was then sealed inside the drum, and the drum was left with the leak point facing downwards for 24 hours. The inside and outside of the drum were then cleaned with the detergent, and the leak point on the outside was applied with a developer (Color Check FD-S, manufactured by Taseto Co., Ltd.) and developed. The drum was disassembled to confirm the coloring of the seam welds.

[0104] In addition, a similar investigation was carried out on two of the drums from Production Example 1 that did not exhibit leakage of the EPA-E composition. The results are also shown in Table 2.

[0105] [Table 2]

[0106] As is clear from the results in Table 2, even products that passed the airtightness test obtained by the helium leak test were found to leak EPA-E composition. Furthermore, of the three drums that were checked for discoloration by the PT check, one had no discoloration, yet still leaked EPA-E composition. This shows that the PT check was unable to completely prevent leakage of EPA-E composition.

[0107] In addition, when a burr inspection was conducted on the drums from which the EPA-E composition had leaked, it was found that burrs were present in two of the three drums.

[0108] In addition, a burr inspection was conducted on the drums that did not leak, and it was confirmed that neither of the two drums had any burrs and passed the burr inspection.

[0109] (Limited sample) For drums where EPA-E composition leakage had occurred, the seam welded portion of the drum was disassembled during the PT check and cut out as a limit sample. During the manufacturing of the drums, drums with small burrs were visually compared with this limit sample and were deemed to have passed the burr inspection.

[0110] When this limit sample was measured, the burr size was 1.3 mm. [Explanation of symbols]

[0111] 10. Torso 10a seam 11 Top plate 12 Main plate 100 packaging containers

Claims

1. A method for inspecting metal packaging containers, comprising: forming a body by forming and seam welding sheet metal, and then attaching a top plate and a bottom plate to the body to form the packaging container, and then performing a burr inspection to inspect the seam portion of the body for the degree of burrs. Testing method.

2. The inspection method of claim 1 , wherein the degree of the burr is based on a size of the burr.

3. The inspection method according to claim 1 or 2, wherein the burr inspection is performed visually.

4. The inspection method according to any one of claims 1 to 3, wherein the burr inspection includes using a limit sample as a reference.

5. A method for manufacturing a metal packaging container, forming and seam welding the sheet metal to form the fuselage; Attaching a top plate and a bottom plate to the body to form the packaging container; Conducting a burr inspection to inspect the degree of burrs on the seam portion of the body of the packaging container; and The packaging container that has passed the burr inspection is selected as a product that has passed the burr inspection. A method for manufacturing a metal packaging container, comprising:

6. The manufacturing method according to claim 5 , wherein the burr dimension of the product that passes the burr inspection is 1.3 mm or less.

7. conducting a gas-tight inspection of the packaging container; Selecting the packaging container that has passed the airtightness test as an airtightness test-passed product; and The burr inspection is carried out on the products that have passed the airtightness inspection. The method of claim 5 or 6, comprising:

8. The inspection method according to any one of claims 1 to 4, or the manufacturing method according to any one of claims 5 to 7, wherein the packaging container is for storing a composition containing a highly unsaturated fatty acid alkyl ester as a main component.

9. Contains 100 or more metal packaging containers, For 98% or more of the 100 or more metal packaging containers, the dimension of the burr at the seam portion of the body of the packaging container is 1.3 mm or less, and The packaging container is for storing a composition containing a highly unsaturated fatty acid alkyl ester as a main component. Packing container assembly.

10. 200 or more of the packaging containers; and For 98% or more of the 200 or more packaging containers, the dimension of the flash at the seam portion of the body of the packaging container is 1.3 mm or less. The packaging container assembly according to claim 9.

11. 11. The packaging container assembly according to claim 9 or 10, wherein the packaging container assembly is made up of continuously manufactured packaging containers.

12. A packing container assembly including 100 or more metal packing containers, wherein 98% or more of the 100 or more packing containers have a burr dimension of 1.3 mm or less at a seam portion of a body of the packing container; and A composition containing, as a main component, a highly unsaturated fatty acid alkyl ester contained in each of the assembly of packaging containers. A packaging assembly comprising:

13. 200 or more of the packaging containers; and For 98% or more of the 200 or more packaging containers, the dimension of the flash at the seam portion of the body of the packaging container is 1.3 mm or less. The package assembly of claim 12.

14. The packaging assembly according to claim 12 or 13, wherein 98% or more of the packaging bodies constituting the packaging assembly are determined to be free of leakage in a content leakage test conducted two weeks or more after the composition has been stored.

15. The packaging assembly according to any one of claims 12 to 14, wherein the packaging assembly comprises continuously manufactured packages.

16. A method for using an indicator to adjust a manufacturing method of a packaging container for storing a composition containing a highly unsaturated fatty acid alkyl ester as a main component, comprising: The indicator includes at least the result of a burr inspection of the packaging container; and The burr inspection includes inspecting the degree of burrs on a seam portion of a body of the packaging container after the top plate and the bottom plate are attached to the body to form the packaging container. How to use the indicator.

17. A composition containing the highly unsaturated fatty acid alkyl ester as a main component, which is contained in the packaging assembly according to any one of claims 12 to 15. A pharmaceutical composition comprising as an active ingredient.

18. The pharmaceutical composition according to claim 17, which is a therapeutic or preventive agent for at least one disease selected from the group consisting of arteriosclerosis, cerebral infarction, myocardial infarction, thrombosis, lifestyle-related diseases, allergies, inflammatory diseases, and cancer.

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