Composition

Abstract

To provide a composition that is unlikely to cause side effects such as discomfort, can prevent increases in blood viscosity, and has anti-inflammatory and analgesic effects.SOLUTION: The composition comprises: cat's claw and purple Ipe, and further comprises: glucosamine, ginger, and vitamin E. It contains 45-53 mass% of cat's claw, 20-28 mass% of purple Ipe, 10-16 mass% of glucosamine, 2-7 mass% of vitamin E, and 6-12 mass% of ginger to the total mass of cat's claw, purple Ipe, glucosamine, ginger, and vitamin E.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present disclosure relates to a composition suitable for use in foods and beverages, supplements, health foods, health supplements, health functional foods, nutritional supplements, nutritional functional foods, functional food products, foods with functional claims, foods for specified health uses, foods for special dietary uses, quasi-drugs, or pharmaceuticals for the purpose of achieving long-term relief of physical stiffness and pain. [Background technology]

[0002] In recent years, lifestyle-related diseases have become a problem for people of all ages, from the elderly to the young, and long-term physical stiffness and pain in particular have a serious negative impact on daily life. It is said that the causes of these diseases include diet, especially the influence of processed foods containing chemically synthesized products, as well as blood contamination and poor blood flow due to the stress of an increasingly complex social life, and an increase in active oxygen.

[0003] Known treatments for such symptoms include massage, compresses, drug therapy using anti-inflammatory agents (see, for example, Patent Document 1), immunomodulators, rehabilitation such as physical therapy and electrical treatment, and therapeutic materials (see, for example, Patent Document 2).

[0004] In recent years, oral compositions containing glucosamine and chondroitin have been proposed to treat knee pain (see, for example, Patent Document 3). [Prior art documents] [Patent documents]

[0005] [Patent Document 1] Japanese Patent Application Laid-Open No. 2011-26256 [Patent Document 2] Japanese Patent Application Laid-Open No. 2014-057819 [Patent Document 3] Japanese Patent Application Laid-Open No. 2015-180687 Summary of the Invention [Problem to be solved by the invention]

[0006] However, massage and compresses are only temporary relief measures, and non-naturally derived drugs may cause discomfort such as side effects compared to natural drugs.

[0007] In recent years, it has also been discovered that long-term physical stiffness and pain are caused in part by an excess of active oxygen due to factors such as poor blood flow and increased blood viscosity caused by impurities in the blood. For example, active oxygen can damage blood vessels, increasing blood viscosity and causing poor circulation, which can lead to physical stiffness and pain.

[0008] However, the above-mentioned conventional techniques are based on symptomatic treatment, and are intended to remove blood flow stagnation when it occurs, rather than being preventative. Furthermore, glucosamine and chondroitin cannot be expected to be sufficiently effective in reducing pain caused by inflammation.

[0009] The present disclosure has been made in light of the above-mentioned problems, and aims to provide a composition that can alleviate long-term physical stiffness and pain. [Means for solving the problem]

[0010] The composition of the present disclosure contains cat's claw and purple ipê, and also contains at least one of glucosamine, ginger, and vitamin E. [Effects of the Invention]

[0011] The compositions of the present disclosure can provide long-term relief from physical stiffness and pain. DETAILED DESCRIPTION OF THE INVENTION

[0012] Hereinafter, embodiments of the composition of the present disclosure will be described. The composition of the embodiment contains cat's claw and purple ipê as main ingredients, and contains at least one of glucosamine, ginger, and vitamin E as auxiliary ingredients. More specifically, the composition of the embodiment contains cat's claw and purple ipê as main ingredients, and contains glucosamine, ginger, and vitamin E as auxiliary ingredients.

[0013] First, each component will be described.

[0014] <Cat's Claw> Cat's claw is a large vine plant that belongs to the Rubiaceae family and grows wild mainly in the Amazon genus in South America. It has square branches and thick thorns like cat's claws at the base of its leaves. There are two varieties, but in this embodiment, we will use the one with the scientific name "Uncaria tomentosa."

[0015] Cat's claw extracts from its roots and bark contain six types of alkaloids, as well as plant sterols, beta-sitosterol, quinovic acid glucoside, and triterpenes.These ingredients have been reported to balance the immune system, enhance the body's natural healing ability, have antioxidant and side-effect-free anti-inflammatory and analgesic effects, and are effective in alleviating the symptoms of rheumatoid arthritis and osteoarthritis.

[0016] For example, a research group from St. Marianna University School of Medicine reported on the anti-inflammatory effects of cat's claw in "Study on the anti-inflammatory effects of cat's claw (1st Japanese Society of Inflammation, July 4-5, 2000 / p523)." Clinical trials are also being conducted, and its use as a complementary and alternative medicine is gaining attention.

[0017] Additionally, the October 2000 issue of Medical Nutrition reports that clinical trials are being conducted by the Sogo Medical Science Institute.

[0018] Furthermore, in the research institute implementation status report of "Basic research on the antioxidant effect of the natural herb cat's claw and the prevention of periodontal disease" conducted by Assistant Professor Miki Kaname of Tokushima University and others from October 21, 2016 to March 31, 2019, and in the case of Professor Okubo Kazuyoshi of Tohoku University, it has been reported that cat's claw extract has a strong ability to eliminate free radicals (a type of active oxygen).

[0019] This was also proven by Peruvian rheumatologist Dr. Salalui, who administered cat's claw to 31 rheumatoid arthritis patients in 1995 and reported significant improvements in arthritis, nighttime pain, and morning stiffness.

[0020] Furthermore, in Japan, at the request of the Embassy of the Republic of Peru and Peruvian companies, clinical trials to evaluate the usefulness and safety of cat's claw for lower back pain and neuralgia have been conducted by Japanese doctors since 1996, and the results of the trials conducted on 20 patients by three doctors, Nemoto Osami, Tanaka Takatake, and Imanishi Toshiyuki, have been reported (see Table 1). Furthermore, in 1994, the World Health Organization (WHO) certified the safety of cat's claw as an anti-inflammatory drug with no side effects. Furthermore, the Ministry of Health, Labor and Welfare announced the safety of cat's claw in its "Integrated Medicine and Information Dissemination Promotion Project." [Table 1]

[0021] <Purple Ipe> Purple ipê (Tabebuia avellanedae) is a tree of the Bignoniaceae family that grows in the Amazon in South America. It is also known as the "miracle medicinal tree" and the "tree blessed by God." Extracts from the inner bark of the tree are used medicinally and are a common medicine in Brazil.

[0022] Purple ipê contains active ingredients such as flavonoids, gelcosides, plant sterols, tembel, saponin, tannin, inositol, pantothenic acid, and other vitamins and minerals.

[0023] Professor Walter Radames Acorn, a botanist at the University of Sao Paulo, who has been scientifically researching the efficacy of purple ipê, has published numerous case studies based on numerous administration cases, together with Dr. Gonçalves de Lema. Of particular note is the activation of the body's natural healing powers by strengthening the blood's purifying power through its promotion of red blood cell production, which has been confirmed to inhibit the proliferation of cancer cells. Furthermore, the peptin substance acts gently on a wide range of affected areas without side effects, relieving symptoms and exhibiting particularly effective anti-inflammatory properties.

[0024] Furthermore, many medical scholars, including Dr. Shinichi Ueda, professor at the Faculty of Pharmaceutical Sciences, Kyoto University, Dr. Harukuni Tokuda of Kanazawa University, and Dr. Takusaburo Ebina, head of the Department of Immunology at the Miyagi Cancer Center Research Institute, have published information on its efficacy, which includes anti-cancer, anti-inflammatory, antioxidant, immune-boosting, anti-analgesic, detoxifying, anti-stress, hormone secretion improving, and anti-allergic effects.

[0025] Regarding the safety of purple ipê, Professor Walter Radames Acorn, a botanist at the University of Sao Paulo, has published a study that found no side effects and no one who used it regularly experienced symptoms of poisoning.

[0026] <Glucosamine> Glucosamine is said to promote the production of proteoglycans that form cartilage, improve the function of weakened joints, support smooth movement between joints and bones, and relieve joint pain.

[0027] <Ginger> Ginger has the effect of warming the body, and its spicy components are "gingjiroge" and "shogaol." The spicy and aromatic components act as an antiseptic, tonic, and diuretic. Its water content is less than 8.0% and total singerols is less than 6.0%.

[0028] <Vitamin E> The scientific name for Vitamin E is "tocopherol," and it has a strong antioxidant effect, fighting off bacteria and viruses in the body. Vitamin E also maintains the health of cells and blood vessels, prevents aging, smooths blood circulation, regulates hormone balance, and relieves stiff shoulders and coldness caused by poor circulation.

[0029] The present disclosure is characterized by a composition that combines the two main ingredients, cat's claw and purple ipê, with three supplementary ingredients, glucosamine, ginger, and vitamin E, in a well-balanced manner, providing a synergistic effect with each ingredient.

[0030] This formula is based on the "theories of traditional Chinese medicine" of traditional Chinese medicine, which refer to the principles of "Kun," "Min," "Jo," and "Shi." "Kun" means the main ingredient, and refers to ingredients that enhance blood production, vitality, and absorption. "Shin" means the auxiliary ingredient, and refers to ingredients that relieve stress, stabilize the autonomic nervous system, and strengthen internal organ functions. "Sa" means a catalyst that increases efficacy, and refers to ingredients that relieve stress, stabilize the autonomic nervous system, and strengthen internal organ functions. "Shi" means a catalyst that speeds up the onset of effects, and refers to ingredients that have blood purification and detoxification effects.

[0031] By determining the compatibility of the above ingredients and mixing them in a balanced manner, a synergistic effect can be expected.

[0032] Example 1 Example 1 is a nutritionally functional food in tablet form intended for oral administration, and contains 39.3% by mass of cat's claw extract powder, 19.6% by mass of purple ipê extract powder, 10.7% by mass of glucosamine, 3.6% by mass of vitamin E powder, 7.1% by mass of ginger extract powder, and 19.6% by mass of excipients relative to the total mass.

[0033] In this example, the cat's claw extract powder is an extract powder obtained by drying and crushing cat's claw bark, extracting it with aqueous ethanol, and spray-drying it into a powder. Specifically, we used "Cat's Claw Extract Powder, Product Number CPX-UGX300" manufactured by Latina Co., Ltd. This product is characterized by being 100% extract powder and containing alkaloids as active ingredients.

[0034] The cat's claw extract powder has an ash content of 10% or less, a moisture content of 4% or less, a loss on drying of 10.0% or less, a powder size of 300 mesh or more (99%), and an alkaloid content of 2.75 to 3.30% (active ingredient).The cat's claw extract powder used in this example has an ash content of 2.85%, a moisture content of 3.7%, a loss on drying of 2.7%, and an alkaloid content of 3.11%.

[0035] The purple ipê extract powder is an extract powder made by extracting the dried bark of purple ipê with aqueous ethanol, adding dextrin, and spray-drying it to make a powder. ``Pau d'Arco (Purple Ipe) Extract Powder 8:1'' manufactured by Latina Co., Ltd. was used.

[0036] The composition of the powder was as follows: moisture content 5.00% or less, ash content 5.00% or less, pH (25°C) 4.50±0.50, specific gravity 0.650±0.050g / ml, and powder size 60 mesh 90% or more.

[0037] The glucosamine used was made from shrimp and crab-derived raw materials that had been crushed, dissolved, filtered, and condensed. It is manufactured by Protein Chemical Co., Ltd. under the trade name "Glucosamine CM-C" and is 100% glucosamine made in Japan.

[0038] The ginger extract powder used was ginger extract powder imported from India by Medience Corporation (product name "G6 Ginger").

[0039] The vitamin E powder is made from d-α-tocopherol, which originates from Brazilian soybeans, and betaine, which originates from Finnish sugar beets, and contains 67 to 73% vitamin E. We used the product name "Vitacoat E-70α" manufactured by Yokohama Oil & Fat Industries Co., Ltd.

[0040] The excipients include potato starch, silicon dioxide, and calcium stearate. Specifically, the excipients preferably contain 16.6 to 17.6 mass% of potato starch, 0.6 to 1.6 mass% of silicon dioxide, and 0.9 to 1.9 mass% of calcium stearate relative to the total mass.

[0041] In this Example 1, the excipient contained 17.1% by mass of potato starch, 1.1% by mass of silicon dioxide, and 1.4% by mass of calcium stearate relative to the total mass.

[0042] (Components of Example 1) The results of analyzing the components of the nutritionally functional food of Example 1 are as follows. This nutritionally functional food contains 5.5% by mass of water, 6.2% by mass of protein, 6.1% by mass of fat, 4.0% by mass of ash, 78.2% by mass of carbohydrates, 0.0383% by mass of sodium, 0.9973% by mass of salt, 2.42% by mass of vitamin E, and 8.65% by mass of glucosamine, and also contains 393 kcl / 100 g of energy.

[0043] (Operation of the First Embodiment) The nutrient functional food of Example 1 is selected appropriately depending on the age and severity of symptoms of the person taking it, and is preferably taken in one to two divided doses per day.

[0044] It was found that the nutrient functional food of Example 1 is applicable to the long-term relief of physical stiffness and pain. The results of administering the nutrient functional food of Example 1 to subjects are described below.

[0045] Subject 1 (age 61) Symptoms: For the past 6 months, the patient has had pain in the left upper arm, which has prevented the patient from lifting the arm. The patient also has stiff shoulders. Dosage: Three tablets were taken in the morning and evening on an empty stomach for three weeks. Results: Pain in the left upper arm was reduced, and stiff shoulders also improved.

[0046] Subject 2 (age 60) Symptoms: One day, when I woke up, I experienced severe pain in my lower back. I went to the hospital for an examination, but no abnormalities were found, and the pain continued and got worse. Dosage: Four tablets were taken on an empty stomach in the afternoon and evening for two weeks. Results: Lower back pain reduced.

[0047] Subject 3 (age 69) He tripped on the stairs and fell, hitting his shoulder hard. He was treated with painkillers at the hospital, but the pain did not go away. It even spread to his lower back, making it difficult for him to get up from bed for six months. Dosage: Five tablets were taken daily for 10 days, followed by eight tablets twice daily. Results: There was no effect when I took five tablets a day, but after taking eight tablets twice a day, the pain was reduced dramatically.

[0048] Subject 4 (77 years old) Symptoms: Long-term neuralgia and rheumatism. Dosage: 8 tablets taken twice a day for 20 days. Results: No effect was observed, so the medication was discontinued.

[0049] Subject 5 (79 years old) Symptoms: The patient developed lower back pain one year ago, and from the 5th day after taking the medication, it became difficult to wake up and walk. An X-ray revealed spinal stenosis, and taking painkillers brought some improvement, but electrical treatment, massage, and compresses were ineffective, and the patient was told surgery was the only option. Status of use: After taking 8 tablets twice a day for 2 months, the patient continued taking 10 tablets a day for 1 month, and is now continuing taking 6 tablets a day. Results: Taking 8 tablets a day made it easier to stand up, and then taking 10 tablets a day rapidly reduced the stiffness and pain in my lower back.

[0050] <Thoughts after use> Below are the responses to a questionnaire about the trial.

[0051] Subject 6 (74-year-old woman) After taking the medicine, the pain subsided and I felt better. I am not currently taking the medicine. Subject 7 (56-year-old female) The knee and hip joint pain that had continued for 10 years has been alleviated, and I am now able to bend my knees. Subject 8 (76-year-old woman) For the past two or three years, I have had lower back pain and stiff fingers, and it has been difficult for me to stand or sit down, but after taking this medicine, the pain has gone away. Subject 9 (73-year-old male) I had been suffering from knee and hip joint pain for the past six months, but after taking this medicine the pain disappeared.

[0052] (Effects of Example 1) 1) The nutritional functional food as the composition of Example 1 has cat's claw and purple ipê as the main ingredients, and contains glucosamine, ginger, and vitamin E as auxiliary ingredients, and further contains 39.3 mass% of the cat's claw extract powder, 19.6 mass% of the purple ipê extract powder, 10.7 mass% of the glucosamine, 3.6 mass% of the vitamin E powder, 7.1 mass% of the ginger extract powder, and 19.6 mass% of the excipients relative to the total mass. Therefore, as can be seen from the above-mentioned experience, the functional food of Example 1 has a long-term effect of relieving "stiffness and pain" and has anti-inflammatory and analgesic effects. This is thought to be due to the efficacy of cat's claw and purple ipê, as well as the remarkable synergistic effect of the combination of the main and auxiliary ingredients based on the "Chinese medicine theory" of Kampo and Oriental medicine.

[0053] Furthermore, the nutritional functional food of Example 1 can prevent an increase in blood viscosity due to the synergistic effect of the enhanced blood purification power of purple ipê and the improving effect of poor blood circulation of vitamin E. This makes it possible to prevent physical stiffness and pain caused by an increase in blood viscosity.

[0054] As described above, the nutrient functional food of Example 1 is a composition characterized by alleviating inflammation in the shoulders and lower back by improving blood circulation disorders through the dilation action of blood vessels. The nutrient functional food of Example 1 is also a composition characterized by promoting the alleviation of pain in various parts of the body. Furthermore, the main ingredients of the nutrient functional food of Example 1 are naturally occurring ingredients that have been used since the time of the Inca Empire, and have been certified as safe by the WHO, making it unlikely to cause discomfort such as side effects.

[0055] 2) In the nutritional functional food as the composition of Example 1, the cat's claw extract powder was made by drying and crushing the bark of cat's claw, extracting the cat's claw extract with aqueous ethanol, and spray-drying it into a powder. Therefore, commercially available products can be used, the composition can be easily produced, and by using natural products, discomfort such as side effects can be reduced.

[0056] 3) In the nutritional functional food as the composition of Example 1, the cat's claw extract powder had an ash content of 10% or less, a moisture content of 4% or less, a loss on drying of 10.0% or less, a powder size of 300 mesh of 99% or more, and an alkaloid content of the active ingredient of 2.75 to 3.30%. Therefore, commercially available products can be used, and the composition can be easily produced. Moreover, since the composition contains a sufficient amount of alkaloids, it can provide anti-inflammatory and analgesic effects, as well as alleviate the symptoms of rheumatoid arthritis and osteoarthritis, and can also provide a synergistic effect due to the combination of the main ingredient and auxiliary ingredients.

[0057] 4) In the nutritional functional food as the composition of Example 1, the purple ipê extract powder was made by drying and crushing the bark of purple ipê, extracting it with aqueous ethanol, adding dextrin to the purple ipê extract, and then spray-drying the purple ipê extract to which textrin had been added, and then powdering it.The ingredients of the powder were moisture content of 5.00% or less, ash content of 5.00% or less, pH (25°C) 4.50±0.50, specific gravity 0.650±0.050g / ml, and powder size of 60 mesh 90% or more. Therefore, commercially available products can be used, and the composition can be easily produced. Furthermore, the active ingredients can include flavonoids, gelcosides, phytosterols, tembel, saponins, tannins, inositol, pantothenic acid, and other vitamins and minerals. This can provide anti-cancer, anti-inflammatory, antioxidant, immune-boosting, anti-analgesic, detoxifying, anti-stress, hormone secretion-improving, and anti-allergic effects, and can also provide a synergistic effect by combining the main and auxiliary ingredients.

[0058] 5) In the nutritional functional food as the composition of Example 1, glucosamine was obtained by crushing, dissolving, filtering and condensing raw materials derived from shrimp and crab. Therefore, commercially available products can be used, and the composition can be easily produced. Furthermore, the effect of alleviating joint pain can be obtained, and a synergistic effect can be obtained by combining the main ingredient and the auxiliary ingredient.

[0059] 6) In the nutritional functional food as the composition of Example 1, the ginger extract powder is a powdered ginger extract, and its components are 8.0% or less in moisture and 6.0% or less in total cinnamol. Therefore, commercially available products can be used, and the composition can be easily prepared. Furthermore, the composition has the effects of an antiseptic, a tonic, and a diuretic, and a synergistic effect can be obtained by combining the main ingredient and the auxiliary ingredient.

[0060] 7) In the nutritional functional food as the composition of Example 1, the vitamin E powder was made from d-α-tocopherol, which originates from soybeans, and betaine, which originates from sugar beets, and had a vitamin E content of 67 to 73%. Therefore, commercially available products can be used, and the composition is easy to manufacture. Moreover, it improves blood circulation, regulates hormone balance, and alleviates stiff shoulders and sensitivity to cold caused by poor circulation, while also providing a synergistic effect due to the combination of the main and auxiliary ingredients. In addition, any other vitamin E powder containing tocopherol may be used. Alternatively, a vitamin E powder produced from soybean-derived tocopherol and sugar beet-derived betaine may be used.

[0061] 8) In the nutritional functional food as the composition of Example 1, the excipients contained potato starch, silicon dioxide, and calcium stearate, and further contained 17.1% by mass of the potato starch, 1.1% by mass of the silicon dioxide, and 1.4% by mass of the calcium stearate relative to the total mass. Therefore, commercially available products can be used, and the composition is easy to manufacture. In addition, since the composition contains an excipient, it is easy to form the nutritionally functional food into tablets. The excipients may be in the range of 14 to 20% by mass of potato starch, 0.4 to 2% by mass of silicon dioxide, and 0.5 to 3% by mass of calcium stearate, based on the total mass. Preferably, the excipients contain 16.6 to 17.6% by mass of potato starch, 0.6 to 1.6% by mass of silicon dioxide, and 0.9 to 1.9% by mass of calcium stearate, which will provide the above-mentioned effects as a nutrient functional food and will be easy to form into tablets. Furthermore, the excipient may contain at least one of potato starch, silicon dioxide, and calcium stearate.

[0062] 9) The nutritionally functional food as the composition of Example 1 contains, relative to the total mass, 5.5% by mass of water, 6.2% by mass of protein, 6.1% by mass of lipids, 4.0% by mass of ash, 78.2% by mass of carbohydrates, 0.0383% by mass of sodium, 0.9973% by mass of salt, 2.42% by mass of vitamin E, and 8.65% by mass of glucosamine, and contains 393 kcl / 100 g of energy. Therefore, it is possible to obtain a nutritionally functional food that can further provide a long-lasting effect of relieving stiffness and pain, as well as anti-inflammatory and analgesic effects.

[0063] Although the embodiments and examples of the present invention have been described in detail above, the specific configurations are not limited to these embodiments and examples, and design changes that do not deviate from the gist of the present invention are included in the present invention.

[0064] For example, in the examples, the supplementary ingredients include all of glucosamine, ginger extract powder, and vitamin E powder, but the supplementary ingredients may include any one or two of these. In other words, a composition containing cat's claw and purple ipê as its main ingredients and at least one of glucosamine, ginger, and vitamin E as auxiliary ingredients not only provides the efficacy of cat's claw and purple ipê, but also provides a synergistic effect from the combination of the main and auxiliary ingredients based on the "Chinese medicine theory" of traditional Chinese medicine and oriental medicine. This allows for long-term relief of stiffness and pain, and provides anti-inflammatory and analgesic effects. In addition, purple ipê enhances the blood's purifying power, preventing an increase in blood viscosity, which is expected to prevent stiffness and pain. Furthermore, because it uses natural ingredients, there is little risk of discomfort such as side effects. In addition, a composition with cat's claw and purple ipê as its main ingredients, and glucosamine, ginger, and vitamin E as its supplementary ingredients, achieves a greater synergistic effect by combining the main ingredients with the supplementary ingredients. This further enhances the long-term relief of stiffness and pain, as well as the anti-inflammatory and analgesic effects. Furthermore, purple ipê's enhanced blood purification ability prevents an increase in blood viscosity, further enhancing the effectiveness in preventing stiffness and pain.

[0065] Furthermore, although the nutritionally functional foods in the examples are in the form of tablets, they may also be in the form of solid preparations such as capsules, powders, granules, etc. In this case, the nutritionally functional food may be a composition that does not contain an excipient. In this way, when no excipient is contained, the composition may contain 45 to 53% by mass of cat's claw, 20 to 28% by mass of purple ipê, 10 to 16% by mass of glucosamine, 2 to 7% by mass of vitamin E, and 6 to 12% by mass of ginger relative to the total mass of cat's claw, purple ipê, glucosamine, ginger, and vitamin E. More preferably, the composition may contain 47.0 to 51.3 mass% of cat's claw or cat's claw extract powder, 22.9 to 25.6 mass% of purple ipê or purple ipê extract powder, 12.0 to 14.1 mass% of glucosamine, 3.6 to 5.1 mass% of vitamin E or vitamin E powder, and 8.4 to 10.3 mass% of ginger or ginger extract powder relative to the total mass of cat's claw, purple ipê, glucosamine, ginger, and vitamin E. Therefore, even in compositions containing cat's claw or its extract, purple ipê or its extract, glucosamine, vitamin E or its powder, and ginger or its extract within the above ranges, a synergistic effect can be expected from the combination of the main and auxiliary ingredients. This provides the anti-inflammatory and analgesic effects to relieve long-term persistent stiffness and pain, and the prevention of body stiffness and pain by preventing an increase in blood viscosity, while the use of naturally derived ingredients reduces the risk of unpleasant side effects.

[0066] More preferably, the composition may contain 48.9% by mass of cat's claw or cat's claw extract powder, 24.4% by mass of purple ipê or purple ipê extract powder, 13.3% by mass of glucosamine, 4.5% by mass of vitamin E or vitamin E powder, and 8.8% by mass of ginger or ginger extract powder relative to the total mass of cat's claw, purple ipê, glucosamine, ginger, and vitamin E. That is, the blending ratios of the above-mentioned cat's claw, purple ipê, glucosamine, ginger, and vitamin E are the same as in Example 1. Therefore, as in Example 1, the synergistic effect of blending the main and auxiliary ingredients based on the "Chinese medicine theory" of Kampo and Oriental medicine provides stronger anti-inflammatory and analgesic effects than when cat's claw and purple ipê are used alone, thereby providing a strong relief effect for long-term persistent "stiffness and pain." In addition, the synergistic effect of the blood purification power of purple ipê and the improvement of poor blood circulation by vitamin E can prevent an increase in blood viscosity. This can prevent stiffness and pain caused by an increase in blood viscosity. Furthermore, by using natural ingredients for each component, the risk of discomfort such as side effects can be reduced.

[0067] Furthermore, the composition of the present disclosure may be a composition with a different formulation from that of Example 1, with the total mass containing 35 to 44% by mass of cat's claw extract powder, made by powdering cat's claw extract, 16 to 23% by mass of purple ipê extract powder, made by powdering purple ipê extract, 8 to 13% by mass of glucosamine, 1 to 6% by mass of vitamin E powder, made by powdering vitamin E, 4 to 10% by mass of ginger extract powder, and 15 to 23% by mass of the excipients. More preferably, the composition may have a different formulation from that of Example 1, with cat's claw extract powder in the range of 39 to 40% by mass, purple ipê extract powder in the range of 19 to 20% by mass, glucosamine in the range of 10 to 11% by mass, vitamin E powder in the range of 3 to 4% by mass, ginger extract powder in the range of 7 to 8% by mass, and excipients in the range of 17 to 22% by mass, relative to the total mass. That is, even in a composition containing cat's claw extract powder, purple ipê extract powder, glucosamine, vitamin E powder, ginger extract powder, and excipients within the above ranges, a synergistic effect can be expected from the combination of the main and auxiliary ingredients. This provides the anti-inflammatory and analgesic effects to relieve long-term persistent stiffness and pain, and the prevention of body stiffness and pain by preventing an increase in blood viscosity, while the use of naturally derived ingredients reduces the risk of unpleasant side effects.

[0068] In addition, in the embodiment, the raw materials cat's claw, purple ipê, glucosamine, ginger, and vitamin E are used in powder form, but depending on the purpose, extracts or solids other than powders may also be used. That is, a composition containing cat's claw, purple ipê, glucosamine, vitamin E, and ginger can be expected to have a synergistic effect due to the combination of the main and auxiliary ingredients, even if it is not in powder form. This provides the anti-inflammatory and analgesic effects to relieve long-term persistent stiffness and pain, and the prevention of body stiffness and pain by preventing an increase in blood viscosity, while the use of naturally derived ingredients reduces the risk of unpleasant side effects.

[0069] Furthermore, although the compositions of the present disclosure are exemplified as functional foods in the examples, they are not limited thereto and may be any of foods and beverages, supplements, health foods, health supplements, functional foods, nutritional supplements, functional foods, functional foods, foods with functional claims, foods for specified health uses, foods for special dietary uses, quasi-drugs, and pharmaceuticals. These formulations can be produced using formulation techniques commonly used in the fields of food and pharmaceuticals. Furthermore, if necessary, ingredients commonly used in foods and pharmaceuticals, such as lubricants, stabilizers, sweeteners, colorants, emulsifiers, and solubilizers, can be added. The foods, drinks, supplements, health foods, health supplements, health functional foods, nutritional supplements, nutritional functional foods, functional food products, foods with functional claims, foods for specified health uses, foods for special dietary uses, quasi-drugs or pharmaceuticals containing the compositions described above have a synergistic effect from the combination of the main and supplementary ingredients based on the "Chinese medicine theory" of Kampo and Oriental medicine, and as a result, they have greater anti-inflammatory and analgesic effects than when cat's claw and purple ipê are used alone, thereby providing a significant relief from long-term persistent stiffness and pain. In addition, the synergistic effect of the blood purification power of purple ipê and the improvement of poor circulation by vitamin E can prevent an increase in blood viscosity, which can prevent stiffness and pain in the body caused by increased blood viscosity. Furthermore, by using naturally occurring ingredients for each component, the risk of causing discomfort such as side effects can be reduced.

[0070] Furthermore, the composition of the present disclosure can be a composition that alleviates inflammation in the shoulders and lower back by improving circulatory disorders through the dilation effect of blood vessels. Therefore, the improvement of blood circulation can alleviate inflammation in the shoulders and lower back. Furthermore, the composition of the present disclosure can be a composition that promotes the improvement of pain in various parts of the body. Therefore, it is possible to promote the improvement of pain in various parts of the body.

Claims

1. A composition comprising cat's claw and purple ipê, and at least one of glucosamine, ginger, and vitamin E.

2. A composition comprising cat's claw and purple ipê, and also comprising glucosamine, ginger, and vitamin E.

3. The composition according to claim 2, comprising 45 to 53% by mass of the cat's claw, 20 to 28% by mass of the purple ipê, 10 to 16% by mass of the glucosamine, 2 to 7% by mass of the vitamin E, and 6 to 12% by mass of the ginger, relative to the total mass of the cat's claw, the purple ipê, the glucosamine, the ginger, and the vitamin E.

4. The composition according to claim 2, wherein the cat's claw, purple ipê, glucosamine, ginger, and vitamin E are in powder form and further contain excipients to shape the product, and the composition contains, relative to the total mass, 35 to 44% by mass of cat's claw extract powder made from powdered cat's claw extract, 16 to 23% by mass of purple ipê extract powder made from powdered purple ipê extract, 8 to 13% by mass of glucosamine, 1 to 6% by mass of vitamin E powder made from powdered vitamin E, 4 to 10% by mass of ginger extract powder made from powdered ginger extract, and 15 to 23% by mass of the excipients.

5. The composition according to claim 4, wherein the cat's claw extract powder is obtained by drying and crushing the bark of the cat's claw, extracting the cat's claw extract with aqueous ethanol, and spray-drying the extract into a powder.

6. The composition described in claim 4, wherein the purple ipê extract powder is obtained by drying and crushing the bark of the purple ipê tree, extracting the purple ipê extract with aqueous ethanol, adding dextrin to the purple ipê extract, and then spray-drying the purple ipê extract to which the textrin has been added.

7. The composition according to claim 4, wherein the glucosamine is obtained by crushing, dissolving, filtering, and condensing raw materials derived from shrimp or crab.

8. The composition according to claim 4, wherein the ginger extract powder is a powdered form of the ginger extract.

9. The composition according to any one of claims 1 to 8, wherein the vitamin E comprises tocopherol.

10. 5. The composition according to claim 4, wherein the vitamin E powder is produced from tocopherol derived from soybeans and betaine derived from sugar beets.

11. 5. The composition of claim 4, wherein the excipient comprises at least one of potato starch, silicon dioxide, and calcium stearate.

12. 5. The composition of claim 4, wherein the excipients include potato starch, silicon dioxide, and calcium stearate.

13. The composition according to claim 12, wherein the excipients comprise 14 to 20% by weight of the potato starch, 0.4 to 2% by weight of the silicon dioxide, and 0.5 to 3% by weight of the calcium stearate, based on the total weight of the composition.

14. The composition according to claim 1 or claim 2, which is any one of a food or drink, a supplement, a health food, a health supplement, a health functional food, a nutritional supplement, a nutritionally functional food, a functional food, a food with functional claims, a food for specified health uses, a food for special dietary uses, a quasi-drug, or a pharmaceutical product.

15. The composition according to claim 14, characterized in that it alleviates inflammation in the shoulders and lower back by improving blood circulation disorders through the dilation of blood vessels.

16. 15. The composition according to claim 14, which promotes the relief of pain in various parts of the body.

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